keyword
https://read.qxmd.com/read/38390369/severe-diastolic-dysfunction-as-a-clue-to-the-cause-of-stroke-a-case-report
#21
Maya Maalouf, William J Mandel, Charles Pollick
BACKGROUND: The echocardiographic determination of cardiac causes of stroke focuses on the presence of left ventricular thrombus, valvular vegetations, and patent foramen ovale. Transoesophageal echocardiogram (TEE) is indicated when the transthoracic echocardiogram (TTE) is inconclusive or when there is clinical suspicion of cardiac causes that may have been missed by TTE. The presence of severe diastolic dysfunction on TTE in the absence of any other cardiac abnormality or cardiac history is not usually considered a clue to the cause of stroke...
February 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38379463/imaging-flow-cytometric-detection-of-del-17p-in-bone-marrow-and-circulating-plasma-cells-in-multiple-myeloma
#22
JOURNAL ARTICLE
Thomas I Mincherton, Stephanie J Lam, Sarah E Clarke, Henry Y L Hui, Jacques A J Malherbe, Hun S Chuah, M Hasib Sidiqi, Kathy A Fuller, Wendy N Erber
BACKGROUND: Detection of del(17p) in myeloma is generally performed by fluorescence in situ hybridization (FISH) on a slide with analysis of up to 200 nuclei. The small cell sample analyzed makes this a low precision test. We report the utility of an automated FISH method, called "immuno-flowFISH", to detect plasma cells with adverse prognostic risk del(17p) in bone marrow and blood samples of patients with myeloma. METHODS: Bone marrow (n = 31) and blood (n = 19) samples from 35 patients with myeloma were analyzed using immuno-flowFISH...
February 21, 2024: International Journal of Laboratory Hematology
https://read.qxmd.com/read/38375211/clinical-profile-and-treatment-of-multiple-myeloma-at-a-tertiary-hospital-in-kenya-a-five-year-retrospective-review
#23
JOURNAL ARTICLE
Wanjiku Gichuru, Nicholas A O Abinya, Andrew Odhiambo, Fredrick C F Otieno, Simon Harrison, Matilda Ong'ondi
BACKGROUND: Multiple myeloma (MM) is a chronic B-cell malignancy that involves proliferation of neoplastic clonal plasma cells in the bone marrow with circulating monoclonal immunoglobulins or constituent chains in serum or urine or both. It is a rare cancer with a lifetime risk of 0.76% and an age-adjusted incidence rate of 2.5-7.2 per 100,000 in high-income countries. There is a paucity of local data on the morbidity and treatment of MM. METHODS: This was a single-centre descriptive retrospective study at the Kenyatta National Hospital (KNH)...
2024: Advances in Hematology
https://read.qxmd.com/read/38371138/spinal-solitary-plasmacytoma-with-minimal-marrow-involvement-presenting-with-epidural-spinal-cord-compression
#24
Rami Al-Handola, Upasana Banerjee, Yasaman Navari, Sarah Ayad, Huda Marcus
Solitary plasmacytoma (SPC) is a rare type of plasma cell dyscrasia characterized by the proliferation of neoplastic monoclonal plasma cells. It can involve bone or soft tissue without signs of systemic disease. The solitary bone plasmacytoma typically involves the axial skeleton, most commonly the vertebrae. This article presents a 58-year-old male with a history of Parkinson's disease, hypertension, and cervical spine degenerative joint disease. He arrived at the emergency department with severe thoracic and lumbar back pain, accompanied by numbness and weakness in both legs, which worsened with movement and deep breathing...
January 2024: Curēus
https://read.qxmd.com/read/38361108/curation-of-myeloma-observational-study-malimar-using-xnat-solving-the-challenges-posed-by-real-world-data
#25
JOURNAL ARTICLE
Simon J Doran, Theo Barfoot, Linda Wedlake, Jessica M Winfield, James Petts, Ben Glocker, Xingfeng Li, Martin Leach, Martin Kaiser, Tara D Barwick, Aristeidis Chaidos, Laura Satchwell, Neil Soneji, Khalil Elgendy, Alexander Sheeka, Kathryn Wallitt, Dow-Mu Koh, Christina Messiou, Andrea Rockall
OBJECTIVES: MAchine Learning In MyelomA Response (MALIMAR) is an observational clinical study combining "real-world" and clinical trial data, both retrospective and prospective. Images were acquired on three MRI scanners over a 10-year window at two institutions, leading to a need for extensive curation. METHODS: Curation involved image aggregation, pseudonymisation, allocation between project phases, data cleaning, upload to an XNAT repository visible from multiple sites, annotation, incorporation of machine learning research outputs and quality assurance using programmatic methods...
February 16, 2024: Insights Into Imaging
https://read.qxmd.com/read/38344747/treatment-of-medication-related-osteonecrosis-of-the-jaw-with-cell-therapy
#26
JOURNAL ARTICLE
Cyril Lucien Bouland, Rokneddine Javadian, Sarah Gilis, Antoine Yanni, Maxime Le Clercq, Pierre Mestrallet, Stelianos Kampouridis, Dominique Bron, Martin Lalmand, Xavier Vanden Eynden, Edward Boutremans, Didier Dequanter, Isabelle Loeb, Pierre Philippart, Laurence Lagneaux, Nathalie Meuleman
Introduction: Medication-related osteonecrosis of the jaw (MRONJ) poses a significant challenge considering the absence of a "gold standard" treatment. Cell-based therapy and tissue engineering offer promising therapeutic alternatives. This study aimed to harness the regenerative properties of adipose-tissue stromal vascular fraction (AT-SVF) and leukocyte-platelet-rich fibrin (L-PRF) for MRONJ treatment. AT-SVF contains mesenchymal stromal cells (MSC) and endothelial progenitor cells (EPC), which promote bone formation, while the L-PRF scaffold can serve as a three-dimensional scaffold for the AT-SVF and support tissue healing through growth factor release...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38344097/solitary-plasmacytoma-of-the-calvarium-a-successful-management-of-a-long-standing-large-lesion-with-a-long-term-follow-up
#27
Abdulaziz M Alghamdi, Taghreed A Alsinani, Alaa Samkari
BACKGROUND: Solitary plasmacytoma of the calvarium (SPC), without evidence of multiple myeloma (MM), is extremely rare. We report a case of a long-standing large SPC that was treated successfully by surgical excision and adjuvant radiotherapy with a long follow-up period. CASE DESCRIPTION: A 58-year-old male patient presented with a 5-year history of painless skull swelling. On the physical examination, the mass was 6 × 6 cm in size, oval, not tender, and firm in consistency with normal skin color...
2024: Surgical Neurology International
https://read.qxmd.com/read/38344096/multiple-myeloma-extramedullary-relapse-at-the-sellar-and-suprasellar-region-after-autologous-stem-cell-transplantation
#28
Orlando De Jesus
BACKGROUND: The effectiveness of autologous stem cell transplantation (ASCT) in preventing the development of central nervous system (CNS) plasmacytomas in multiple myeloma (MM) patients is not well understood. An ASCT patient who developed CNS extramedullary (EM) lesions is presented. The literature was reviewed for similar cases in which the transplant did not prevent the development of CNS lesions. CASE DESCRIPTION: A 42-year-old female was evaluated after complaining of a sudden severe headache and complete vision loss...
2024: Surgical Neurology International
https://read.qxmd.com/read/38327916/atypical-presentation-and-diagnosis-of-multiple-myeloma-a-case-report
#29
Iris Kong, Luke W Riddell, Jacquelyn M Kohler, Michael C Nguyen, Michelle N Carraro
Chronic neck pain is a common, seemingly benign condition that typically does not warrant an urgent workup, in contrast to acute onset neck pain. Vertebral artery dissection (VAD) is a relatively rare presentation of acute onset neck pain and often presents in the context of blunt trauma. Due to the risk of subsequent clot formation and stroke, patients who present with symptoms suggestive of VAD must be promptly screened, most often first with computed tomography angiography (CTA) followed by magnetic resonance imaging (MRI) or magnetic resonance angiography (MRA) for further evaluation...
January 2024: Curēus
https://read.qxmd.com/read/38326481/development-of-a-whole-spinal-mri-based-tumor-burden-scoring-method-in-participants-with-multiple-myeloma-a-pilot-study-of-prognostic-significance
#30
JOURNAL ARTICLE
Sha Cui, Yinnan Guo, Jianting Li, Wenjin Bian, Wenqi Wu, Wenjia Zhang, Qian Zheng, Haonan Guan, Jun Wang, Jinliang Niu
The aim of the study was to develop a new whole spinal MRI-based tumor burden scoring method in participants with newly diagnosed multiple myeloma (MM) and to explore its prognostic significance. We prospectively recruited participants with newly diagnosed MM; performed whole spinal MRI (sagittal FSE T1 WI, sagittal IDEAL T2 WI, and axial FLAIR T2 WI) on them; and collected their clinical data, early treatment response, progression-free survival (PFS), and overall survival (OS). We developed a new tumor burden scoring method according to the extent of bone marrow infiltration in five MRI patterns...
February 7, 2024: Annals of Hematology
https://read.qxmd.com/read/38290886/bone-marrow-biopsies-is-ct-fluoroscopy-or-no-imaging-guidance-the-most-cost-effective-strategy
#31
JOURNAL ARTICLE
Soterios Gyftopoulos, Madalena Da Silva Cardoso, Jim S Wu, Naveen Subhas, Connie Y Chang
RATIONALE AND OBJECTIVES: To determine the most cost-effective strategy for pelvic bone marrow biopsies. MATERIALS AND METHODS: A decision analytic model from the health care system perspective for patients with high clinical concern for multiple myeloma (MM) was used to evaluate the incremental cost-effectiveness of three bone marrow core biopsy techniques: computed tomography (CT) guided, and fluoroscopy guided, no-imaging (landmark-based). Model input data on utilities, costs, and probabilities were obtained from comprehensive literature review and expert opinion...
January 29, 2024: Academic Radiology
https://read.qxmd.com/read/38286937/-68-ga-pentixafor-pet-ct-for-staging-and-prognostic-assessment-of-newly-diagnosed-multiple-myeloma-comparison-to-18-f-fdg-pet-ct
#32
JOURNAL ARTICLE
Zhenying Chen, Apeng Yang, Aihong Chen, Jinfeng Dong, Junfang Lin, Chao Huang, Jiaying Zhang, Huimin Liu, Zhiyong Zeng, Weibing Miao
PURPOSE: To evaluate the prognostic performance of [68 Ga]Pentixafor PET/CT at baseline for staging of patients with newly diagnosed multiple myeloma (MM) and to compare it with [18 F]FDG PET/CT and the Revised-International Staging System (R-ISS). METHODS: Patients who underwent [68 Ga]Pentixafor and [18 F]FDG PET/CT imaging were retrospectively included. Patient staging was performed according to the Durie-Salmon PLUS staging system based on [68 Ga]Pentixafor PET/CT and [18 F]FDG PET/CT images, and the R-ISS...
January 30, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38283701/plasma-cell-leukemia-with-soft-tissue-involvement-reporting-a-rare-case
#33
Ahmed Bendari, Rahaf M Abu Khalaf, Sunder Sham, Reham Al-Refai, Oana Vele, Alyssa Yurovitsky
Plasma cell leukemia (PCL) is a rare aggressive variant of multiple myeloma. PCL is diagnosed when clonal plasma cells constitute more than 20 % of the total circulating leukocytes or when the absolute plasma cell count exceeds 2 × 109  /L. Extramedullary involvement including cavity effusion is frequently seen at the time of diagnosis. However, soft tissue involvement is rarely encountered with only one published case in the English literature. We report a 74-year-old man, who presented with progressive shortness of breath over a few months...
2024: Leukemia Research Reports
https://read.qxmd.com/read/38282332/imaging-very-late-antigen-4-on-molt4-leukemia-tumors-with-cysteine-site-specific-89-zr-labeled-natalizumab-immuno-positron-emission-tomography
#34
JOURNAL ARTICLE
Mina Kim, Kyung-Ho Jung, Jung Lim Kim, Hyun-Jung Koo, Hye Jin Jung, Hyunjong Lee, Kyung-Han Lee
Very late antigen-4 (VLA4; CD49d) is a promising immune therapy target in treatment-resistant leukemia and multiple myeloma, and there is growing interest in repurposing the humanized monoclonal antibody (Ab), natalizumab, for this purpose. Positron emission tomography with radiolabeled Abs (immuno-PET) could facilitate this effort by providing information on natalizumab's in vivo pharmacokinetic and target delivery properties. In this study, we labeled natalizumab with 89 Zr specifically on sulfhydryl moieties via maleimide-deferoxamine conjugation...
January 28, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38258554/oncolytic-myxoma-virus-increases-autophagy-in-multiple-myeloma
#35
JOURNAL ARTICLE
Alpay Yeşilaltay, Dilek Muz, Berna Erdal
BACKGROUND: Multiple myeloma (MM), which affects plasma cells, is the second most common hematological malignancy. Despite the development of new drugs and treatment protocols, patient survival has not reached the desired level. In this study, we investigated the effects of Myxoma virus (MYXV), an oncolytic virus, on autophagy in myeloma cells. METHOD: We analyzed protein expression of ATG-5, p62, Beclin-1, LC3B, and the apoptosis marker Bcl-2 as autophagy markers in human U-266 and mouse MOPC 315 myeloma cell lines treated with different doses of MYXV...
January 23, 2024: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://read.qxmd.com/read/38254683/harnessing-nanotechnology-emerging-strategies-for-multiple-myeloma-therapy
#36
REVIEW
Min Yang, Yu Chen, Li Zhu, Liangshun You, Hongyan Tong, Haitao Meng, Jianpeng Sheng, Jie Jin
Advances in nanotechnology have provided novel avenues for the diagnosis and treatment of multiple myeloma (MM), a hematological malignancy characterized by the clonal proliferation of plasma cells in the bone marrow. This review elucidates the potential of nanotechnology to revolutionize myeloma therapy, focusing on nanoparticle-based drug delivery systems, nanoscale imaging techniques, and nano-immunotherapy. Nanoparticle-based drug delivery systems offer enhanced drug targeting, reduced systemic toxicity, and improved therapeutic efficacy...
January 9, 2024: Biomolecules
https://read.qxmd.com/read/38247993/plasmacytoma-in-the-maxillary-jaw-a-diagnostic-and-therapeutic-challenge
#37
Sara Bernardi, Serena Bianchi, Ettore Lupi, Davide Gerardi, Guido Macchiarelli, Giuseppe Varvara
Plasmacytoma is a neoplastic disorder originating from plasma cells, with bone and soft tissue being common sites of manifestation. This report presents the clinical and radiological findings of a 65-year-old female patient who presented with an exophytic lesion in the upper right lateral incisor region. The lesion appeared as a unilocular radiotransparent area in imaging tests. Following an excisional biopsy, histological and immunohistochemical evaluations confirmed the presence of mature plasmacellular elements and small infiltrates of B and T lymphocytes...
January 4, 2024: Hematology Reports
https://read.qxmd.com/read/38247079/-onset-of-testicular-plasmacytoma-in-a-patient-with-refractory-multiple-myeloma
#38
JOURNAL ARTICLE
Akiko Kin, Masahiro Manabe, Nobuhiro Sogabe, Satoru Nanno, Satoshi Hatanaka, Kazuya Morimoto, Yukio Yoneda, Takeshi Mazaki, Ki Ryang Koh
A 72-year-old male patient, who had been on chemotherapy for the treatment of IgG-λ multiple myeloma, presented an enlargement of the testis 3 years and 5 months after the diagnosis. High orchiectomy was then performed, leading to the diagnosis of plasmacytoma. Due to residual disease, treatment with a combination of isatuximab and dexamethasone was initiated. The patient is currently under follow-up without recurrence. While testicular tumors are difficult to diagnose by imaging studies alone and extramedullary plasmacytomas rarely occur in the testis, pathological assessment is critical for treatment planning...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38244697/impact-of-visceral-obesity-on-clinical-outcome-and-quality-of-life-for-patients-with-multiple-myeloma-a-secondary-data-analysis-of-stamina-bmt-ctn-0702-trial
#39
JOURNAL ARTICLE
Ehsan Malek, Jeries Kort, Leland Metheny, Pingfu Fu, Gen Li, Parameswaran Hari, Yvonne Efebera, Natalie S Callander, Muzaffar H Qazilbash, Sergio Giralt, Amrita Krishnan, Edward A Stadtmauer, Hillard M Lazarus
Obesity is a common health problem among multiple myeloma (MM) patients, and it has been linked to poor clinical outcomes and quality of life (QOL). We conducted a secondary analysis of the BMT CTN 0702, a randomized, controlled trial comparing outcomes of three treatment interventions after a single hematopoietic cell transplant (HCT) (N = 758), to investigate the impact of visceral obesity, as measured by waist-to-hip ratio (WHR), on clinical outcomes and QOL in MM patients. A total of 549 MM patients, median age 55...
January 18, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38238146/mri-based-bone-marrow-radiomics-for-predicting-cytogenetic-abnormalities-in-multiple-myeloma
#40
JOURNAL ARTICLE
X Xiong, J Wang, Z Hao, X Fan, N Jiang, X Qian, R Hong, Y Dai, C Hu
AIM: To develop a radiomics signature applied to magnetic resonance imaging (MRI)-images to predict cytogenetic abnormalities in multiple myeloma (MM). MATERIALS AND METHODS: Patients with newly diagnosed MM were enrolled retrospectively from March 2019 to September 2022. They were categorised into the high-risk cytogenetics (HRC) group and standard-risk cytogenetics (SRC) group. The patients were allocated randomly at a ratio of 7:3 into training and validation cohorts...
January 6, 2024: Clinical Radiology
keyword
keyword
67485
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.