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Diabetic coma

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https://www.readbyqxmd.com/read/29606344/agraphia-with-reversible-splenial-corpus-callosum-lesion-caused-by-hypoglycemia
#1
Yukari Miyakawa, Tatsuo Fuchigami, Masako Aoki, Yusuke Mine, Junichi Suzuki, Tatsuhiko Urakami, Shori Takahashi
BACKGROUND: Neurological manifestations caused by hypoglycemia range from reversible focal deficits and transient encephalopathy to irreversible coma or death. Recently, high signal intensity lesions in the splenium of the corpus callosum on diffusion-weighted magnetic resonance imaging were reported in adults experiencing hypoglycemia. However, patients presenting with agraphia are rare. SUBJECT AND METHODS: We examined a 17-year-old left-handed female patient with type 1 diabetes who exhibited transient left agraphia with a reversible splenium lesion of the corpus callosum on diffusion-weighted imaging caused by hypoglycemia, which was improved with blood glucose management alone...
March 29, 2018: Brain & Development
https://www.readbyqxmd.com/read/29577222/-establishment-of-comprehensive-prediction-model-of-acute-gastrointestinal-injury-classification-of-critically-ill-patients
#2
Yan Wang, Jianrong Wang, Weiwei Liu, Guangliang Zhang
OBJECTIVE: To develop the comprehensive prediction model of acute gastrointestinal injury (AGI) grades of critically ill patients. METHODS: From April 2015 to November 2015, the binary channel gastrointestinal sounds (GIS) monitor system which has been developed and verified by the research group was used to gather and analyze the GIS of 60 consecutive critically ill patients who were admitted in Critical Care Medicine of Chinese PLA General Hospital. Also, the AGI grades (Grande I(-IIII(, the higher the level, the heavier the gastrointestinal dysfunction) were evaluated...
March 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29555548/working-party-approved-by-the-french-society-of-anaesthesia-and-intensive-care-medicine-sfar-and-the-french-society-for-the-study-of-diabetes-sfd
#3
Gaëlle Cheisson, Sophie Jacqueminet, Emmanuel Cosson, Carole Ichai, Anne-Marie Leguerrier, Bogdan Nicolescu-Catargi, Alexandre Ouattara, Igor Tauveron, Paul Valensi, Dan Benhamou
Follow on from continuous intravenous administration of insulin with an electronic syringe (IVES) is an important element in the postoperative management of a diabetic patient. The basal-bolus scheme is the most suitable taking into account the nutritional supply and variable needs for insulin, reproducing the physiology of a normal pancreas: (i) slow (long-acting) insulin (= basal) which should immediately take over from IVES insulin simulating basal secretion; (ii) ultra-rapid insulin to simulate prandial secretion (= bolus for the meal); and (iii) correction of possible hyperglycaemia with an additional ultra-rapid insulin bolus dose...
March 16, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29486630/diabetic-ketoacidosis-among-pregnant-and-non-pregnant-women-a-comparison-of-morbidity-and-mortality
#4
Michelle Rougerie, Nicholas Czuzoj-Shulman, Haim A Abenhaim
PURPOSE: Diabetic ketoacidosis (DKA) is a critical diagnosis that can cause severe morbidity and mortality in the diabetic population. Although it is rare in pregnancy, the aim of this study is to compare DKA in pregnant women with age-matched non-pregnant women to determine if outcomes are influenced by pregnancy. MATERIALS AND METHODS: A population-based age-matched retrospective cohort was carried out using data from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample from 1999 to 2013...
February 27, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29484801/brain-injury-markers-s100-calcium-binding-protein-b-neuron-specific-enolase-and-glial-fibrillary-acidic-protein-in-children-with-diabetic-ketoacidosis
#5
Gönül Çatlı, Ahmet Anık, Sezer Acar, Tuncay Küme, Melike Karabulut, Özlem Gürsoy Çalan, Bumin Nuri Dündar, Ayhan Abacı
BACKGROUND: To investigate serum levels of brain injury markers in diabetic ketoacidosis (DKA) and the relation of these markers with clinical and radiological findings of brain injury and laboratory results. METHODS: Twenty-nine patients with DKA, 30 with type 1 diabetes mellitus (T1DM), and 35 healthy children were included. Clinical and laboratory findings, and the Glasgow Coma Scale (GCS) were recorded. In the DKA group, neuron-specific enolase (NSE), S100 calcium-binding protein B (S100B) and glial fibrillary acidic protein (GFAP) levels were measured at baseline and 6 and 12 hours after treatment...
February 27, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29449530/the-type-2-diabetes-associated-hmg20a-gene-is-mandatory-for-islet-beta-cell-functional-maturity
#6
Jose M Mellado-Gil, Esther Fuente-Martín, Petra I Lorenzo, Nadia Cobo-Vuilleumier, Livia López-Noriega, Alejandro Martín-Montalvo, Irene de Gracia Herrera Gómez, Maria Ceballos-Chávez, Laura Gómez-Jaramillo, Antonio Campos-Caro, Silvana Y Romero-Zerbo, Júlia Rodríguez-Comas, Joan-Marc Servitja, Gemma Rojo-Martinez, Abdelkrim Hmadcha, Bernat Soria, Marco Bugliani, Piero Marchetti, Francisco J Bérmudez-Silva, Jose C Reyes, Manuel Aguilar-Diosdado, Benoit R Gauthier
HMG20A (also known as iBRAF) is a chromatin factor involved in neuronal differentiation and maturation. Recently small nucleotide polymorphisms (SNPs) in the HMG20A gene have been linked to type 2 diabetes mellitus (T2DM) yet neither expression nor function of this T2DM candidate gene in islets is known. Herein we demonstrate that HMG20A is expressed in both human and mouse islets and that levels are decreased in islets of T2DM donors as compared to islets from non-diabetic donors. In vitro studies in mouse and human islets demonstrated that glucose transiently increased HMG20A transcript levels, a result also observed in islets of gestating mice...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29431405/hyperosmolar-hyperglycemic-state
#7
Gregg D Stoner
Hyperosmolar hyperglycemic state is a life-threatening emergency manifested by marked elevation of blood glucose and hyperosmolarity with little or no ketosis. Although there are multiple precipitating causes, underlying infections are the most common. Other causes include certain medications, nonadherence to therapy, undiagnosed diabetes mellitus, substance abuse, and coexisting disease. In children and adolescents, hyperosmolar hyperglycemic state is often present when type 2 diabetes is diagnosed. Physical findings include profound dehydration and neurologic symptoms ranging from lethargy to coma...
December 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29405355/cortisol-evaluation-during-the-acute-phase-of-traumatic-brain-injury-a-prospective-study
#8
Meriem Bensalah, Malcolm Donaldson, Yamina Aribi, Malek Iabassen, Lyes Cherfi, Mustapha Nebbal, Meriem Medjaher, ElMehdi Haffaf, Benaissa Abdennebi, Mustapha Guenane, Adel Djermane, Zahra Kemali, Samia OuldKablia
BACKGROUND: Biochemical diagnosis of adrenal insufficiency (AI) is difficult in the context of traumatic brain injury (TBI) AIM: to assess the frequency and predictive factors of AI in victims of TBI from Algiers. METHODS: Between November 2009 and December 2013, TBI victims had a single 8-9 a.m. serum cortisol measurement during the acute post injury period (0-7 days). AI was defined according to basal cortisol levels of 83, 276 and 414 nmol/L. Variables studied were TBI severity according to Glasgow coma scale, duration of intubation and coma, pupillary status, hypotension, anemia, brain imaging findings, diabetes insipidus and medication...
February 5, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29400569/the-value-of-the-identification-of-predisposing-factors-for-post-traumatic-amnesia-in-management-of-mild-traumatic-brain-injury
#9
George Fotakopoulos, Demosthenes Makris, Eleni Tsianaka, Polikceni Kotlia, Paulos Karakitsios, Charalabos Gatos, Alkiviadis Tzannis, Kostas Fountas
OBJECT: To identify the risk factors for post-traumatic amnesia (PTA) and to document the incidence of PTA after mild traumatic brain injuries. METHODS: This was a prospective study, affecting mild TBI (mTBI) (Glasgow Coma Scale 14-15) cases attending to the Emergency Department between January 2009 and April 2012 (40 months duration). Patients were divided into two groups (Group A: without PTA, and Group B: with PTA, and they were assessed according to the risk factors...
February 5, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29396187/diabetes-care-and-dementia-among-older-adults-a-nationwide-3-year-longitudinal-study
#10
Matthieu Wargny, Adeline Gallini, Hélène Hanaire, Fati Nourhashemi, Sandrine Andrieu, Virginie Gardette
OBJECTIVES: To compare diabetes monitoring and the incidence of acute diabetic complications between patients with and without incident Alzheimer's Disease and Related Syndromes (ADRS). DESIGN: Longitudinal observational study from 2010 to 2014. SETTING: Data from the French national health system database. PARTICIPANTS: The France-Démence cohort: individuals aged 65 years or older suffering from incident ADRS, based on long-term disease registry, hospitalization for dementia, or antidementia drug delivery...
January 25, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29301583/which-factor-is-the-most-effective-one-in-metabolic-sydrome-on-the-outcomes-after-coronary-artery-bypass-graft-surgery-a-cohort-study-of-5-years
#11
Lijuan Wang, Xiangyang Qian, Mingya Wang, Xinran Tang, Hushan Ao
BACKGROUND: Metabolic Syndrome and diabetes mellitus are risk factors for cardiovascular disease. However, the effects of Metabolic Syndrome with or without diabetes on perioperative and long-term morbidity and mortality after Coronary Artery Bypass Graft remain unclear. METHODS: An retrospective study was performed on 1166 patients who received isolated primary Coronary Artery Bypass Graft in Fuwai hospital. They were divided into three groups: control, Metabolic Syndrome of three factors together with diabetes and Metabolic Syndrome of three factors without diabetes (n = 868, 76 and 222 respectively)...
January 4, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29284568/clinical-characteristics-of-subarachnoid-hemorrhage-with-an-intracerebral-hematoma-and-prognostic-factors
#12
Masaaki Nemoto, Hiroyuki Masuda, Yuki Sakaeyama, Sinichi Okonogi, Yasuhiro Node, Keita Ueda, Shunpei Ando, Kosuke Kondo, Naoyuki Harada, Nobuo Sugo
BACKGROUND: Subarachnoid hemorrhage (SAH) with an intracerebral hematoma (ICH) shows an unfavorable prognosis. In the present study, we examined the characteristics of SAH with ICH and its prognosis. METHODS: Subjects comprised 218 patients with SAH who underwent surgery between January 2007 and December 2015. We compared age, sex, the location of the aneurysm, treatment procedures, medical history (hypertension, diabetes, and heart disease), the Glasgow Coma Scale (GCS) score on admission, rerupture rate, hydrocephalus, the diameter of the aneurysm, cerebral vasospasm, perioperative cardiopulmonary complications, and the Glasgow Outcome Scale (GOS) score after 2 months between patients with SAH with and without ICH...
May 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29258472/pediatric-non-diabetic-ketoacidosis-a-case-series-report
#13
Ke Bai, Yueqiang Fu, Chengjun Liu, Feng Xu, Min Zhu
BACKGROUND: This study is to explore the clinical characteristics, laboratory diagnosis, and treatment outcomes in pediatric patients with non-diabetic ketoacidosis. METHODS: Retrospective patient chart review was performed between March 2009 to March 2015. Cases were included if they met the selection criteria for non-diabetic ketoacidosis, which were: 1) Age ≤ 18 years; 2) urine ketone positive ++ or >8.0 mmol/L; 3) blood ketone >3.1 mmol/L; 4) acidosis (pH < 7...
December 19, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29246631/assessment-of-percheron-infarction-in-images-and-clinical-findings
#14
Zhihua Xu, Lingling Sun, Yang Duan, Jinghua Zhang, Mengzhi Zhang, Xiaonan Cai
OBJECTIVE: To assess the imaging and clinical features of patients with an artery of Percheron infarction comprehensively. METHODS: Of 6539 patients with a first-ever stroke, 18 patients with a Percheron infarction were enrolled, and their images and clinical data were retrospectively investigated. RESULTS: All patients underwent neurological intensive care unit (NICU) management. The initial symptom of a Percheron infarction included dizziness, transient blurred vision, double vision, barylalia, cerebellar ataxia, drowsiness, and a coma...
December 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29218766/risk-of-recurrent-severe-hypoglycemia-remains-associated-with-a-past-history-of-severe-hypoglycemia-up-to-4-years-results-from-a-large-prospective-contemporary-pediatric-cohort-of-the-dpv-initiative
#15
D Pacaud, J M Hermann, B Karges, J Rosenbauer, T Danne, R Dürr, A Herbst, S Lindauer, S Müther, S Pötzsch, K Raile, M Witsch, R W Holl
OBJECTIVES: In a contemporary cohort of youth with type 1 diabetes, we examined the interval between episodes of severe hypoglycemia (SH) as a risk factor for recurrent SH or hypoglycemic coma (HC). METHODS: This was a large longitudinal observational study. Using the DPV Diabetes Prospective follow-up data, we analyzed frequency and timing of recurrent SH (defined as requiring assistance from another person) and HC (loss of consciousness or seizures) in 14 177 youths with type 1 diabetes aged <20 years and at least 5 years of follow-up...
December 8, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29181767/frailty-diabetes-and-the-convergence-of-chronic-disease-in-an-age-related-condition-a-population-based-nationwide-cross-sectional-analysis-of-the-mexican-nutrition-and-health-survey
#16
Roberto C Castrejón-Pérez, Carlos A Aguilar-Salinas, Luis M Gutiérrez-Robledo, Matteo Cesari, Mario U Pérez-Zepeda
AIMS: To describe the associations of frailty with diabetes mellitus and related conditions in older adults. METHODS: We conducted a cross-sectional analysis of a representative sample of older adults (n = 5379). We generated a 35-item frailty index (FI) and obtained information on diabetes and related conditions (peripheral neuropathy, lower limb amputation, diabetic coma, number of physician visits due to diabetes-related conditions, all-cause hospitalizations in the past year, years since diabetes diagnosis, and type of treatment)...
November 27, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29180613/analysis-of-risk-factors-for-hypoglycemic-coma-in-194-patients-with-type-2-diabetes
#17
Zefen Lu, Jianfeng Liu, Qing He, Anindita Chakraborty, Tiehong Zhu
BACKGROUND The present study was conducted to analyze possible risk factors in patients with type 2 diabetes who are in hypoglycemic coma. MATERIAL AND METHODS A total of 194 patients with type 2 diabetic hypoglycemic coma who were admitted to our hospital between January 2010 and January 2016 were included. The patients were all in coma on admission, and their blood glucose levels were lower than 2.8 mmol/L. None of the patients had type I diabetes, specific types of diabetes, or gestational diabetes. Multiple linear regression analysis was used to determine possible factors associated with hypoglycemic coma...
November 28, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29170119/adult-patients-with-pneumococcal-meningitis-at-a-neurosurgical-neurologic-center-different-predisposing-conditions
#18
Lucero de María Ugalde-Mejía, Veronica Angeles Morales, Graciela Cárdenas, Jose Luis Soto-Hernández
BACKGROUND: In previous studies of pneumococcal meningitis in adults within general hospitals or national cohorts, the most common predisposing conditions were otitis media, sinusitis, pneumonia, immunosuppression, alcoholism, and diabetes. The epidemiology of pneumococcal meningitis is changing because of the use of vaccines in childhood, and antibiotic resistance has increased. METHODS: We retrospectively reviewed the cases of patients with diagnoses of pneumococcal meningitis proved by an inflammatory cerebrospinal fluid (CSF) with a positive culture, treated during a period of 14 years at an adult neurosurgical neurologic referral center...
February 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29088954/morbidity-and-mortality-associated-with-hypernatremia-in-patients-with-severe-traumatic-brain-injury
#19
Aditya Vedantam, Claudia S Robertson, Shankar P Gopinath
OBJECTIVE Hypernatremia is independently associated with increased mortality in critically ill patients. Few studies have evaluated the impact of hypernatremia on early mortality in patients with severe traumatic brain injury (TBI) treated in a neurocritical care unit. METHODS A retrospective review of patients with severe TBI (admission Glasgow Coma Scale score ≤ 8) treated in a single neurocritical care unit between 1986 and 2012 was performed. Patients with at least 3 serum sodium values were selected for the study...
November 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29079281/association-of-classic-cardiovascular-risk-factors-and-lifestyles-with-the-cardio-ankle-vascular-index-in-a-general-mediterranean-population
#20
Marc Elosua-Bayés, Ruth Martí-Lluch, María Del Mar García-Gil, Lourdes Camós, Marc Comas-Cufí, Jordi Blanch, Anna Ponjoan, Lia Alves-Cabratosa, Roberto Elosua, María Grau, Jaume Marrugat, Rafel Ramos
INTRODUCTION AND OBJECTIVES: The cardio-ankle vascular index (CAVI) assesses arterial stiffness. We aimed to describe the distribution of CAVI in a Mediterranean population, to determine the proportion of CAVI ≥ 9 by sex and coronary risk level, and to assess the association of CAVI with classic cardiovascular risk factors and lifestyle patterns. METHODS: This cross-sectional study was based on the population of Girona province. The CAVI was measured using the VaSera VS-1500...
October 25, 2017: Revista Española de Cardiología
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