Adrenal insufficency

Adreno-cortical insufficiency in the context of an adrenal mass can be a challenging clinical problem. The two main possibilities are either a benign mass or a malignant pathology. We describe here a patient who was investigated for chronic adreno-cortical insufficiency and was found to have a left adrenal mass that was later confirmed histopathologically to be tuberculous in nature.

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The triple A or Allgrove's syndrome is an autosomal recessive disorder characterized by the triad of achalasia cardia, alacrima and ACTH resistant adrenocortical insufficiency. Mutations of the Achalasia-Addisonianism-Alacrima-Syndrome (AAAS) gene on chromosome 12q13 are associated with this syndrome. We report an Indian family where two siblings were homozygous for a known mutation of the AAAS gene and presented with the classical triad of symptoms. The mother and the brother were heterozygous and asymptomatic...

Diurnal periodicity of the glucocorticoid function of the adrenal cortex was studied in 52 patients with atherosclerotic cardiosclerosis without and with circulatory insufficency of the I, IIA and IIB stage, based on the determination of 17-OCS in 3 portions of the urine collected at equal 8-hours long time intervals. The patients without circulatory insufficiency and with insufficiency of the 1st stage received ascorbic acid in amounts of 0.3 g thrice a day, along with vitamins B1 and B6 (5 and 6 per cent) in doses of 1 ml for 14-16 days...