Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
Nicole Ann E Villa, Dragos G Pausescu, Eduardo D Espiridion
Psychiatric polypharmacy involves the use of two or more psychotropic medications to manage a mental and emotional condition. The prevalence of psychotropic polypharmacy has been increasing since the 1990s and has been attributed to the rise in multiple psychiatric conditions presenting in one patient. However, as the prevalence of polypharmacy increases to maximize therapeutic advantages, so does the adverse effect profile of those drugs used in combination, leading to very life-threatening effects such as agranulocytosis...
March 2024: Curēus
#2
REVIEW
Meenakshi Sachdeva, Meenakshi Malik, Pranita Pradhan, Kulbir Kaur, Sarita Dogra, Joseph L Mathew
BACKGROUND: Two approaches are used to manage invasive fungal disease (IFD) in febrile neutropenic patients viz. empirical therapy (without attempting to confirm the diagnosis), or pre-emptive therapy (after screening tests for IFD). OBJECTIVE: This systematic review was undertaken to compare these approaches in children. METHODS: We searched PubMed, EMBASE, Cochrane Library, Scopus, Web of Science, CINAHL, Clinical Trial Registries and grey literature, for randomized controlled trials (RCT) comparing empirical versus pre-emptive antifungal therapy in children with FN suspected to have IFD...
April 2024: Mycoses
#3
JOURNAL ARTICLE
Sidika Gülkan Özkan, Ali Kimiaei, Seyedehtina Safaei, Meral Sönmezoğlu, Hasan Atilla Özkan
Introduction Despite the development of modern antibiotic and antifungal therapies, neutropenic infections remain life-threatening. Granulocyte transfusion (GTX) is a less frequently used treatment modality in patients with refractory neutropenic infections. The role of donor GTX remains controversial, partly because of the lack of proper clinical trials. This study aimed to contribute to the literature by evaluating the efficacy and side effects of granulocyte transfusions in our center. Methods Eight febrile neutropenic patients with confirmed infections received granulocyte transfusions from ABO-compatible related and unrelated donors...
March 2024: Curēus
#4
JOURNAL ARTICLE
Muhammad Haris Khan, Muhammad Adnan Wattoo, Habib Ur Rehman Butt, Muhammad Zaid, Umair Tahir, Mehwish Kaneez, Usaid Munir Joyia, Syed Faheem Bukhari
Background Acute leukemia, characterized by the uncontrolled proliferation of immature white blood cell precursors, poses significant challenges during induction chemotherapy, including the elevated risk of febrile neutropenia and its associated complications. Our study aims to explain the clinical and etiological parameters of these patients in a resource-limited setting. Methods This retrospective study focused on a total of 102 adult patients with acute leukemia who developed febrile neutropenia during the induction chemotherapy phase...
February 2024: Curēus
#5
JOURNAL ARTICLE
Selma Çakmakcı, Neriman Sarı, Çiğdem Sönmez, İnci Ergürhan İlhan
BACKGROUND: We assessed the relationship between sepsis occurrence and the serum levels of angiopoietin (Ang-1, Ang-2), vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in pediatric patients with cancer-related febrile neutropenia. METHODS: Fifty-two children with malignant tumors who experienced 86 episodes of febrile neutropenia (FN) were examined between June 2016 and June 2018. Each FN episode was considered a separate event and the total number of FNs were recorded (86 FN episodes = FN group)...
2024: Turkish Journal of Pediatrics
#6
JOURNAL ARTICLE
Minkyeong Lee, Chan Mi Lee, Ja Min Byun, Dong-Yeop Shin, Youngil Koh, Junshik Hong, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Sung-Soo Yoon, Myoung-Don Oh, Chang Kyung Kang, Inho Kim
BACKGROUND: Gram-positive bacteria are frequently resistant to empirical beta-lactams in febrile neutropenic patients with cancer. As microbiology and antibiotic susceptibility changes, we reevaluated the risk factors for resistant Gram-positive bacteremia in febrile neutropenic patients with cancer. METHODS: Episodes of bacteremic febrile neutropenia in Seoul National University Hospital from July 2019 to June 2022 were reviewed. Resistant Gram-positive bacteria were defined as a pathogen susceptible only to glycopeptide or linezolid in vitro (e...
March 20, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#7
RANDOMIZED CONTROLLED TRIAL
Vicky Coyle, Caroline Forde, Richard Adams, Ashley Agus, Rosemary Barnes, Ian Chau, Mike Clarke, Annmarie Doran, Margaret Grayson, Danny McAuley, Cliona McDowell, Glenn Phair, Ruth Plummer, Dawn Storey, Anne Thomas, Richard Wilson, Ronan McMullan
BACKGROUND: Neutropenic sepsis is a common complication of systemic anticancer treatment. There is variation in practice in timing of switch to oral antibiotics after commencement of empirical intravenous antibiotic therapy. OBJECTIVES: To establish the clinical and cost effectiveness of early switch to oral antibiotics in patients with neutropenic sepsis at low risk of infective complications. DESIGN: A randomised, multicentre, open-label, allocation concealed, non-inferiority trial to establish the clinical and cost effectiveness of early oral switch in comparison to standard care...
March 2024: Health Technology Assessment: HTA
#8
JOURNAL ARTICLE
Esra Arslantaş, Kamuran Şanlı, Sultan Okur Acar, Sibel Akpınar Tekgündüz, Ali Ayçiçek
Granulocytes are the most important cells for host defense during infections. Granulocyte suspension transfusions (GTx) may be given as additional treatment in severely neutropenic patients with life-threatening infections when antimicrobial therapy is inadequate. The aim of this study was to evaluate the effectiveness and safety of GTx for the treatment of children with hemato-oncological disease, febrile neutropenia and serious life-threatening infections. Patients who underwent GTx between July 2020 and September 2022 were evaluated retrospectively...
February 20, 2024: Transfusion and Apheresis Science
#9
JOURNAL ARTICLE
Merve Cansu Polat, Çiğdem Sönmez, Neşe Yarali, Namık Yaşar Özbek
The purpose of this study was to evaluate the association between interleukin-33 (IL-33) and its receptor Soluble Suppression of Tumorigenicity-2 (sST2) levels and bacterial infections during febrile neutropenia (FN) in pediatric patients with acute lymphoblastic leukemia (ALL). In this prospective, case-control study, participants were divided into 3 groups: ALL patients with FN (Group A), ALL patients without neutropenia and fever (Group B), and healthy children without infection and chronic disease (Group C)...
February 17, 2024: European Journal of Pediatrics
#10
JOURNAL ARTICLE
Ryoji Kobayashi, Hirozumi Sano, Satoru Matsushima, Daiki Hori, Masato Yanagi, Daisuke Suzuki
BACKGROUND: Control of bacterial and fungal infections is critical to improving outcomes in hematological neoplastic diseases of children and adolescents. In this study, a retrospective analysis of our previous studies on febrile neutropenia was performed to investigate bacteremia. PROCEDURE: From August 2008 to December 2023, five antibiotic studies were performed for febrile and neutropenic pediatric patients who had been treated with chemotherapy, immunosuppressive therapy, or had received stem cell transplantation in the pediatric unit at Sapporo Hokuyu Hospital...
January 30, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#11
JOURNAL ARTICLE
Invasive Fungal Infections in Children with Acute Leukemia: Epidemiology, Risk Factors, and Outcome.
Tamar Ruth Gal Etzioni, Nurit Fainshtain, Adi Nitzan-Luques, Gal Goldstein, Sigal Weinreb, Violeta Temper, Maya Korem, Dina Averbuch
Invasive fungal infections (IFI) cause morbidity and mortality in children with acute leukemia (AL). We retrospectively collected data on febrile neutropenic episodes (FNE) in AL children (2016-2021) and assessed factors associated with proven/probable IFI. Ninety-three children developed 339 FNE. Seventeen (18.3%) children developed 19 proven/probable IFI (11 yeast; eight molds). The proven/probable yeast IFI rate was 6/52 (11.5%) in children who belong to the high risk for IFI category (HR-IFI-AL: high-risk acute lymphocytic leukemia (ALL), acute myeloid leukemia, relapse); and 5/41 (12...
January 11, 2024: Microorganisms
#12
JOURNAL ARTICLE
Claire Durand, Karine Risso, Michael Loschi, Nicolas Retur, Audrey Emery, Johan Courjon, Thomas Cluzeau, Michel Carles
BACKGROUND: The 4th European Conference on Infections in Leukemia recommends early adaptation of empirical antibiotic therapy (EAT) for febrile neutropenia in stable patients. OBJECTIVES: To assess the efficacy of an antimicrobial stewardship (AMS) intervention promoting early de-escalation and discontinuation of EAT in high-risk neutropenic patients. METHODS: This before-after study was conducted in the hematology department of the University Hospital of Nice, France...
January 17, 2024: Antimicrobial Resistance and Infection Control
#13
JOURNAL ARTICLE
Connor Prosty, Khaled Katergi, Alex Nguyen, Owen Dan Luo, Mark Sorin, Vladimir Cherniak, Michael Sebag, Koray Demir, Emily G McDonald, Todd C Lee, Matthew P Cheng
Venetoclax is a small molecule inhibitor of BCL-2 used in the treatment of acute myelogenous leukemia (AML) and chronic lymphocytic leukemia (CLL). Recent postmarketing studies of ibrutinib, another small molecule inhibitor, suggested that these agents may predispose to opportunistic infections. We sought to systematically review the randomized controlled trial (RCT) evidence of venetoclax to assess whether it predisposes patients to infectious adverse events (IAEs) and neutropenia. We systematically reviewed RCTs comparing venetoclax therapy with active or placebo controls for patients with hematologic malignancies...
February 27, 2024: Blood Advances
#14
JOURNAL ARTICLE
Mark Kristjanson, Pascal Lambert, Kathleen M Decker, Sonja Bruin, Elizabeth Tingey, Pamela Skrabek
UNLABELLED: Large doses of steroids are integral to R-CHOP, a first-line systemic therapy for diffuse large B-cell lymphoma (DLBCL), an aggressive form of non-Hodgkin Lymphoma (NHL). Patients on R-CHOP often develop clinically significant hyperglycemia from steroids. There is evidence of harms from steroid-induced hyperglycemia in the context of chemotherapy which are associated with a reduction in overall survival. The objective of our study was to characterize the effect of steroid-induced hyperglycemia on the outcomes of R-CHOP chemotherapy for DLBCL...
November 28, 2023: Current Oncology
#15
JOURNAL ARTICLE
Valentine Delanote, Rutger Callens, Dirk Vogelaers, Dries Deeren
OBJECTIVES: Patients treated for hematologic malignancies are at higher risk for blood stream infections (BSI) and multidrug-resistant organisms (MDRO) are increasingly involved. Studies showed a significant association between rectal colonization status and a higher risk of subsequent MDRO BSI. The objective of our study was to probe the practice of surveillance cultures in Belgian hematology centers. METHODS: A questionnaire was sent to the 13 hematology centers participating in the acute leukemia board of the Belgian Hematology Society...
April 2024: European Journal of Haematology
#16
JOURNAL ARTICLE
Michelle Tew, Abby P Douglas, Jeff Szer, Ashish Bajel, Simon J Harrison, Shio Yen Tio, Leon J Worth, Rodney J Hicks, David Ritchie, Monica A Slavin, Karin A Thursky, Kim Dalziel
BACKGROUND: A recent randomised trial demonstrated [18 F]fluorodeoxyglucose positron-emission tomography in combination with low-dose CT (FDG-PET/CT), compared to standard of care computed tomography (CT) imaging, positively impacted antimicrobial management and outcomes of acute leukaemia and haematopoietic stem cell transplant recipients with persistent and recurrent neutropenic fever. We conducted an economic evaluation from a healthcare perspective alongside the clinical trial. METHODS: Unit costs in Australian dollars were applied to all resources used (antimicrobials, diagnostic tests, ICU and hospital bed days)...
December 15, 2023: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
#17
JOURNAL ARTICLE
Zhiguo Zhao, Pratik A Patel, Leonora Slatnick, Anna Sitthi-Amorn, Kevin J Bielamowicz, Farranaz A Nunez, Alexandria M Walsh, Jennifer Hess, Jenna Rossoff, Caitlin Elgarten, Regina Myers, Raya Saab, Maya Basbous, Meghan Mccormick, Catherine Aftandilian, Rebecca Richards, C Nathan Nessle, Alison C Tribble, Jessica K Sheth Bhutada, Scott L Coven, Daniel Runco, Jennifer Wilkes, Arun Gurunathan, Terri Guinipero, Jennifer A Belsky, Karen Lee, Victor Wong, Megha Malhotra, Amy Armstrong, Lauren P Jerkins, Shane J Cross, Lyndsay Fisher, Madison T Stein, Natalie L Wu, Troy Yi, Etan Orgel, Gabrielle M Haeusler, Joshua Wolf, Jenna M Demedis, Tamara P Miller, Adam J Esbenshade
PURPOSE: The optimal management of fever without severe neutropenia (absolute neutrophil count [ANC] ≥500/µL) in pediatric patients with cancer is undefined. The previously proposed Esbenshade Vanderbilt (EsVan) models accurately predict bacterial bloodstream infections (BSIs) in this population and provide risk stratification to aid management, but have lacked prospective external validation. MATERIALS AND METHODS: Episodes of fever with a central venous catheter and ANC ≥500/µL occurring in pediatric patients with cancer were prospectively collected from 18 academic medical centers...
March 1, 2024: Journal of Clinical Oncology
#18
JOURNAL ARTICLE
Halima El Omri, Regina Padmanabhan, Ruba Y Taha, Nancy Kassem, Hesham Elsabah, Anil Yousaf Ellahie, Antonio J J Santimano, Muna A Al-Maslamani, Ali S Omrani, Adel Elomri, Abdelfatteh El Omri
BACKGROUND: The use of ill-suited antibiotics is a significant risk factor behind the increase in the mortality, morbidity, and economic burden for patients who are under treatment for hematological malignancy (HM) and bloodstream infections (BSI). Such unfitting treatment choices intensify the evolution of resistant variants which is a public health concern due to possible healthcare-associated infection spread to the general population. Hence, this study aims to evaluate antibiograms of patients with BSI and risk factors associated with septicemia...
January 2024: Journal of Infection and Public Health
#19
JOURNAL ARTICLE
Mohammadreza Bordbar, Mehdi Vahidifar, Mohammad Mehdi Zarshenas, Sezaneh Haghpanah, Soheila Zareifar, Mahdi Shahriari, Omid Reza Zekavat, Mehran Karimi, Gholamreza Fathpour, Arman Zargaran, Nader Shakibazad
INTRODUCTION: Febrile neutropenia is a serious complication of cancer chemotherapy that can result in delays in treatment. This study evaluates the efficacy of A. ampeloprasum L. at neutrophil recovery time in children with chemotherapy-associated febrile neutropenia. METHODS: This single-center, parallel-group, double-blind, randomized clinical trial was conducted at an oncology hospital. Patients selected among childhood cancers with febrile neutropenia. Overall, 97 febrile neutropenic children were enrolled...
2023: American Journal of Blood Research
#20
JOURNAL ARTICLE
Lori Melikian, Susan Bullington, Brent Harris, Cole Smith, Justin Roberts, Chad Naville-Cook, Brooke Crawford
BACKGROUND: Febrile neutropenia (FN) is a life-threatening oncologic emergency requiring timely evaluation and treatment. Unrecognized fever and infection can progress quickly and have been shown to increase morbidity and mortality in patients with malignancy. It is critical to identify patients with neutropenic fever on presentation to the emergency department (ED) and to initiate treatment immediately. OBSERVATIONS: This quality improvement initiative sought to optimize ED care of patients presenting with FN...
August 2023: Federal Practitioner
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
