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febrile neutropenic

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https://www.readbyqxmd.com/read/28286615/detection-of-legionella-pneumophila-in-urine-and-serum-specimens-of-neutropenic-febrile-patients-with-haematological-malignancies
#1
Nastaran Farzi, Zahra Abrehdari-Tafreshi, Omid Zarei, Leili Chamani-Tabriz
Background: Legionella pneumophila (L. pneumophila) is a gram-negative bacterium which causes ‎Legionnaires' disease as well as Pontiac fever. The Legionella infections in patients suffering from ‎neutropenia- as a common complication of cancer chemotherapy- can distribute rapidly. We ‎aimed to detect of L. pneumophila in haematological malignancy suffering patients with ‎neutropenic fever by targeting the (macrophage infectivity potentiator) mip gene. Subjects andMethods: Serum and ‎urine specimens were obtained from 80 patients and presence of mip gene of L...
January 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28283020/carbapenem-resistant-klebsiella-pneumoniae-in-high-risk-haematological-patients-factors-favouring-spread-risk-factors-and-outcome-of-carbapenem-resistant-klebsiella-pneumoniae-bacteremias
#2
Alessandra Micozzi, Giuseppe Gentile, Clara Minotti, Claudio Cartoni, Saveria Capria, Daniele Ballarò, Stefania Santilli, Emanuele Pacetti, Sara Grammatico, Giampaolo Bucaneve, Robin Foà
BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) spread and infections in patients with haematological malignancies are a serious concern especially in endemic areas. Treatment failures and delay in appropriate therapy for CRKP infections are frequent and the mortality rate associated with CRKP bacteremia in neutropenic haematological patients is reported about 60%. METHODS: Haematological patients harboring CRKP hospitalized between February 2012 and May 2013 in an Italian Teaching hospital were examined...
March 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28283014/-fungemia-and-septic-arthritis-caused-by-saprochaete-capitata-in-a-patient-with-fanconi-aplastic-anemia-a-case-report
#3
Ömür Mustafa Parkan, Mustafa Altay Atalay, Ayşe Nedret Koç, Çiğdem Pala, Gonca Aydemir, Leylagül Kaynar
Saprochaete capitata (formerly known as Blastoschizomyces capitatus, Trichosporon capitatum, Geotrichum capitatum) is a rare but emerging yeast-like fungus. It is commonly found in environmental sources and can be isolated from skin, gastrointestinal system and respiratory tract of healthy individuals as well. It mainly infects patients with hematological malignancies such as acute myeloid leukemia (AML), especially in the presence of neutropenia; and mortality rates are high in those patients. Although the data about the in vitro antifungal susceptibility are limited, it is being reported that amphotericin B and voriconazole are more effective on S...
January 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28245405/-efficacy-and-safety-of-low-dose-amphotericin-b-in-different-antifungal-strategies-for-treatment-of-invasive-fungal-disease-in-patients-with-hematological-malignancies
#4
Lan Yang, Xiang-Shu Jin, Jing-He Li, Jing Liu, Wei Guan, Hong-Hao Gao, Yu Jing
OBJECTIVE: To evaluate the efficacy and safety of low-dose amphotericin B (AmB) in different antifungal strategies for treatment of invasive fungal disease(IFD) in patients with hematologic malignancies. Metheds: The clinical dada of the patients were collected and analyzed retrospectively and the levels of creatinine (Cr), urea nitrogen (BUN) and potassium (K(+)) before and after using low-dose AmB were compared and statistically analyzed. RESULTS: Among 97 cases, 2 cases were diagnosed as invasive fungal disease (IFD), 11 cases were diagnosed as clinical probable IFD, 15 cases were diagnosed as possible IFD, 69 cases were undefined IFD...
February 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28222086/equivalence-study-of-two-temperature-measurement-methods-in-febrile-adult-patients-with-cancer
#5
Tina M Mason, Abdelbaki Boubekri, Jennifer Lalau, Amy Patterson, Susan R Hartranft, Steven K Sutton
PURPOSE/OBJECTIVES: To assess equivalence of temperatures taken via temporal artery and oral methods in febrile inpatients with cancer.
. DESIGN: Repeated measures equivalence design.
. SETTING: 24-bed hematology-oncology unit and 36-bed blood and marrow transplantation unit at H. Lee Moffitt Cancer Center and Research Institute, a National Cancer Institute-designated comprehensive cancer center in Tampa, Florida.
. SAMPLE: Convenience sample of 58 febrile inpatients using 60 temperature measurements...
March 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28219330/empiric-treatment-against-invasive-fungal-diseases-in-febrile-neutropenic-patients-a-systematic-review-and-network-meta-analysis
#6
Ken Chen, Qi Wang, Roy A Pleasants, Long Ge, Wei Liu, Kangning Peng, Suodi Zhai
BACKGROUND: The most optimal antifungal agent for empiric treatment of invasive fungal diseases (IFDs) in febrile neutropenia is controversial. Our objective was evaluate the relative efficacy of antifungals for all-cause mortality, fungal infection-related mortality and treatment response in this population. METHODS: Pubmed, Embase and Cochrane Library were searched to identify randomized controlled trials (RCTs). Two reviewers performed the quality assessment and extracted data independently...
February 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28190625/-the-inverted-halo-sign-in-a-febrile-neutropenic-patient
#7
R Perolat, O Stephanov, A Mounier, A Thiebaut, A Pirvu, R Hamidfar, G Ferretti
No abstract text is available yet for this article.
February 9, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28152679/better-utilization-of-neutropenic-precautions-and-adherence-to-guidelines-to-improve-cost-effectiveness-and-patient-convenience
#8
Shada Attraplsi, Yehuda Z Lebowicz
227 Background: Cancer patient are generally immunocompromised and are at increased risk of infections once absolute neutrophils count is less than 500. The aim of the study to evaluate the inpatient utilization of a standardized neutropenic precautions in cancer patients admitted with febrile neutropenia. METHODS: From Jan 2010 to May 2015, established cancer patients were included in this retrospective study who were admitted in Cabel Huntington hospital, Huntington, WV with a diagnosis of febrile neutropenia and were placed on Neutropenic precautions (NP)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28109549/time-kill-determination-of-the-bactericidal-activity-of-telavancin-and-vancomycin-against-clinical-methicillin-resistant-staphylococcus-aureus-isolates-from-cancer-patients
#9
Kenneth Vi Rolston, Weiqun Wang, Lior Nesher, Jordan R Smith, Michael J Rybak, Randall A Prince
The bactericidal activity of vancomycin and telavancin was compared against 4 clinical methicillin-resistant Staphylococcus aureus isolates recently recovered from cancer patients, using minimum bactericidal concentration (MBC):MIC ratios and time-kill studies. All 4 isolates were susceptible to both agents based on individual MIC values. The 2 methodologies for assessing bactericidal activity produced variable results. Telavancin appeared to have somewhat better bactericidal activity than vancomycin based on narrower MBC:MIC ratios...
April 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28079821/febuxostat-induced-agranulocytosis-in-an-end-stage-renal-disease-patient-a-case-report
#10
Xue Er Poh, Chien-Te Lee, Sung-Nan Pei
INTRODUCTION: Febuxostat, a nonpurine xanthine oxidase inhibitor, is approved as the first-line urate-lowering therapy in gout patients with normal renal function or mild to moderate renal impairment. The most common adverse effects of febuxostat are liver function test abnormalities, diarrhea, and skin rash. However, there is insufficient data in patients with severe renal impairment and end-stage renal disease (ESRD). We report the first case, to our knowledge, in which agranulocytosis developed after febuxostat treatment in an ESRD patient...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28077045/association-of-time-to-antibiotics-and-clinical-outcomes-in-adult-hematologic-malignancy-patients-with-febrile-neutropenia
#11
Allison R Butts, Christina Carracedo Bachmeier, Emily V Dressler, Meng Liu, Ann Cowden, Jeff Talbert, Val R Adams
Objective The objective of this study was to determine the clinical impact of time to antibiotic administration in adult inpatients who have hematologic malignancies and develop febrile neutropenia. Methods A retrospective chart review was conducted to screen for all febrile neutropenia events amongst adult hematologic malignancy patients between 1 January 2010 and 1 September 2014. All included patients were admitted to the hospital at the time of fever onset, having been admitted for a diagnosis other than febrile neutropenia...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28041827/application-of-the-mascc-and-cisne-risk-stratification-scores-to-identify-low-risk-febrile-neutropenic-patients-in-the-emergency-department
#12
Christopher J Coyne, Vivian Le, Jesse J Brennan, Edward M Castillo, Rebecca A Shatsky, Karen Ferran, Stephanie Brodine, Gary M Vilke
STUDY OBJECTIVE: Although validated risk-stratification tools have been used to send low-risk febrile neutropenic patients home from clinic and inpatient settings, there is a dearth of research evaluating these scores in the emergency department (ED). We compare the predictive accuracy of the Multinational Association for Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) scores for patients with chemotherapy-induced febrile neutropenia and presenting to the ED...
December 29, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27922236/microorganisms-isolated-from-cultures-and-infection-focus-and-antibiotic-treatments-in-febrile-neutropenic-children-from-%C3%A5-anl%C3%A4-urfa-turkey
#13
Z Canan Özdemir, Ahmet Koç, Ali Ayçiçek
Chemotherapy induced febrile neutropenia predisposes patients to life threatening infections. We aimed to determine the causative microorganisms, infection focus and antibiotic treatment success in febrile neutropenic children with leukemia. A total of 136 febrile neutropenic episodes in 48 leukemic children were reviewed retrospectively from records. Among 136 febrile neutropenic episodes, 68 (50%) episodes were microbiologically documented. Methicillin sensitive coagulase (-) Staphylococcus aureus were the most common isolates from hemoculture (20...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27904453/outcome-of-severe-infections-in-afebrile-neutropenic-cancer-patients
#14
Ksenija Strojnik, Ksenija Mahkovic-Hergouth, Barbara Jezersek Novakovic, Bostjan Seruga
BACKGROUND: In some neutropenic cancer patients fever may be absent despite microbiologically and/or clinically confirmed infection. We hypothesized that afebrile neutropenic cancer patients with severe infections have worse outcome as compared to cancer patients with febrile neutropenia. PATIENTS AND METHODS: We retrospectively analyzed all adult cancer patients with chemotherapy-induced neutropenia and severe infection, who were admitted to the Intensive Care Unit at our cancer center between 2000 and 2011...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27904098/relationship-between-pk-pd-of-cefepime-and-clinical-outcome-in-febrile-neutropenic-patients-with-normal-renal-function
#15
Yoshiko Yamashita, Hidekazu Kamiyama, Asuka Yamamoto, Hiroki Kanoh, Yoshimitsu Yuhki, Akira Ueda, Yukari Kawamoto, Yoshikazu Gotoh, Satoshi Yamamoto
 The efficacy of cefepime (CFPM) is known to depend on the ratio of the time that the serum levels exceed the minimum inhibitory concentration (MIC) to the dosing interval (%T>MIC). The objective of this study was to clarify the relation between %T>MIC and clinical outcome of CFPM, and to identify the optimal dosage regimen. We investigated the outcome of CFPM treatment for febrile neutropenia (FN) patients with normal renal function. Treatment success was defined as the completion of FN therapy with CFPM only...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27873451/a-prospective-randomized-trial-comparing-piperacillin-tazobactam-with-meropenem-as-empirical-antibiotic-treatment-of-febrile-neutropenic-children-and-adolescents-with-hematologic-and-malignant-disorders
#16
Hirozumi Sano, Ryoji Kobayashi, Daisuke Suzuki, Daiki Hori, Kenji Kishimoto, Kunihiko Kobayashi
BACKGROUND: This randomized prospective study was designed to assess whether piperacillin/tazobactam (PIPC/TAZ) is as effective as meropenem (MEPM) as a first-line antibiotic treatment for febrile neutropenia (FN). PROCEDURE: FN episodes were randomly assigned to receive either PIPC/TAZ (337.5 mg/kg per day in three doses, 1-hr DIV, maximum 13.5 g per day) or MEPM (120 mg/kg per day in three doses, 1-hr DIV, maximum 3 g per day). Clinical responses were evaluated 120 hr after the DIV...
November 22, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27819257/preemptive-antifungal-therapy-for-febrile-neutropenic-hematological-malignancy-patients-in-china
#17
Wei Yuan, Jinhai Ren, Xiaonan Guo, Xiaoling Guo, Shengxin Cai
BACKGROUND The aim of this study was to evaluate the efficiency, adverse effects, and pharmacoeconomic impact of empirical and preemptive antifungal therapy for febrile neutropenic hematological malignancy patients in China. MATERIAL AND METHODS Patients with febrile neutropenia during hematological malignancy were randomly divided into an empirical group and a preemptive group. The preemptive antifungal treatment was initiated if patient status was confirmed by clinical manifestation, imaging diagnosis, 1-3-β-D glucan(G) testing, and galactomannan (GM) test...
November 7, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27817239/modified-docetaxel-cisplatin-and-fluorouracil-therapy-as-the-first-line-treatment-for-patients-with-recurrent-metastatic-squamous-cell-carcinoma-of-the-head-and-neck-cancer-a-retrospective-study
#18
Nebi Serkan Demirci, Sercan Aksoy, Nuriye Yıldırım Özdemir, Gökmen Umut Erdem, Melike Ozcelik, Eda Tanrikulu, Tülay Eren, Yakup Bozkaya, Süleyman Sahin, Fatma Başol, Suheyla Aytac Aslan, Nurullah Zengin, İbrahim Güllü
AIM: Modified docetaxel, cisplatin, and 5-fluorouracil (mDCF) therapy has been shown to be a well tolerated and highly effective regimen for metastatic gastric carcinoma. Herein we investigated the effectiveness of the mDCF combination as the first-line treatment in patients with recurrent/metastatic squamous cell carcinoma of the head and neck (HNSCC). METHODS: A total of 80 patients with recurrent/metastatic HNSCC who were treated with mDCF between 2009 and 2015 were enrolled into this study...
December 8, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27813352/use-of-computed-tomography-abdomen-and-pelvis-for-investigation-of-febrile-neutropenia-in-adult-haematology-patients
#19
H Y Lim, M Ashby, B Williams, A Grigg
We retrospectively evaluated the use of computed tomography abdomen and pelvis (CTAP) in febrile neutropenic autologous stem cell transplant (ASCT) and acute myeloid leukaemia (AML) patients. CTAP was more common in ASCT patients (59%) compared with AML (31%; P  < 0.001). Although abnormal findings were reported in 51%, only 10% resulted in therapy change (addition of anaerobic antibiotic/bowel rest), which would have otherwise been instituted based on clinical grounds. CTAP in these patients rarely provide useful information unsuspected clinically...
November 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27803612/painless-neutropenic-enterocolitis-in-a-patient-undergoing-chemotherapy
#20
E J Chow, K D Bishop
CASE DESCRIPTION: A 60-year-old man developed painless neutropenic enterocolitis after induction chemotherapy for newly diagnosed acute myelogenous leukemia. The patient had recurrent fever while neutropenic, without experiencing abdominal pain or tenderness on physical examination. His diagnosis was delayed by the fact that he had no localizing symptoms. DISCUSSION: Neutropenic enterocolitis is a common complication, generally occurring in patients who are severely neutropenic; the condition presents with fever and abdominal pain...
October 2016: Current Oncology
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