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https://www.readbyqxmd.com/read/27902644/coffee-consumption-and-risk-of-nonmelanoma-skin-cancer-a-dose-response-meta-analysis
#1
Golnaz Vaseghi, Shaghayegh Haghjoo-Javanmard, Jamal Naderi, Azadeh Eshraghi, Manijeh Mahdavi, Marjan Mansourian
Several epidemiological studies have evaluated the associations between coffee consumption and the risk of skin cancer; however, the results were not conclusive. This systematic review and meta-analysis of the cohort and case-control studies was carried out to determine the association between coffee intake and the risk of nonmelanoma skin cancer. Studies were identified by searching the PubMed and MEDLINE databases (to November 2015). Study-specific risk estimates were pooled under the random-effects model...
November 29, 2016: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27898109/body-mass-index-and-risk-of-non-melanoma-skin-cancer-cumulative-evidence-from-prospective-studies
#2
Daijun Zhou, Jun Wu, Gaoxing Luo
Prospective epidemiologic studies that investigated the association between body mass index (BMI) and non-melanoma skin cancer (NMSC) yielded inconsistent findings. A dose-response meta-analysis was conducted to quantitatively summarize the evidence. PubMed and Embase databases were searched for relevant studies. Study-specific relative risk (RR) and 95% confidence interval (CI) for an increase in BMI of 5 kg/m(2) was computed with the generalized least squares trend estimation, and these risk estimates were combined with the random-effects model...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896185/the-relationship-between-the-size-and-the-invasion-depth-of-tumors-in-head-and-neck-cutaneous-squamous-cell-carcinoma
#3
Sam Yong Lee, Won Joo Hwang, Kyung Pil Kim, Hong Min Kim, Jae Ha Hwang, Kwang Seog Kim
BACKGROUND: Cutaneous squamous cell carcinoma (SCC), which occurs in keratinocytes of the epidermis and is the second most common skin cancer, has a more invasive growth pattern and higher potential to metastasize than basal cell carcinoma. Total excision of the primary tumor is the treatment of choice. For clear excision of the tumor, invasion depth is one of the most important factors. This study was conducted to clarify the relationship between the size and the invasion depth of cutaneous SCC...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27892984/anatomical-distributions-of-basal-cell-carcinoma-and-squamous-cell-carcinoma-in-a-population-based-study-in-queensland-australia
#4
Padmini Subramaniam, Catherine M Olsen, Bridie S Thompson, David C Whiteman, Rachel E Neale
Importance: Keratinocyte cancers (KCs), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the most common cancers among fair-skinned populations worldwide. Although studies have indicated that the anatomical distribution of BCC and SCC differ, few have compared them directly in well-defined population samples. Objectives: To describe and compare the anatomical distribution of BCC and SCC in a population-based sample in Queensland, Australia...
November 23, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27892658/occupational-syncarcinogenesis-in-the-skin-combined-effects-of-two-carcinogens-from-the-german-occupational-disease-list
#5
Heinrich Dickel, Otto Blome, Beate Dickel, Thomas Bruckner, Eggert Stockfleth, Silas Paras Soemantri
BACKGROUND: Though scientifically undisputed, cutaneous syncarcinogenesis is not reflected in German occupational disease (OD) regulations, which tend to be guided by the tenet of monocausality. Recognition of nonmelanoma skin cancer (NMSC) and its precursor lesions as OD requires individual assessment as to whether the requirements pursuant to either OD 5103 (occupational exposure to natural UV radiation) or OD 5102 (occupational exposure to polycyclic aromatic hydrocarbons) are fulfilled...
November 28, 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27892649/thresholding-methods-for-lesion-segmentation-of-basal-cell-carcinoma-in-dermoscopy-images
#6
R Kaur, R LeAnder, N K Mishra, J R Hagerty, R Kasmi, R J Stanley, M E Celebi, W V Stoecker
PURPOSE: Algorithms employed for pigmented lesion segmentation perform poorly on dermoscopy images of basal cell carcinoma (BCC), the most common skin cancer. The main objective was to develop better methods for BCC segmentation. METHODS: Fifteen thresholding methods were implemented for BCC lesion segmentation. We propose two error metrics that better measure the type II error: Relative XOR Error and Lesion Capture Ratio. RESULTS: On training/test sets of 305 and 34 BCC images, respectively, five new techniques outperform two state-of-the-art methods used in segmentation of melanomas, based on the new error metrics...
November 28, 2016: Skin Research and Technology
https://www.readbyqxmd.com/read/27879972/responses-of-metastatic-basal-cell-and-cutaneous-squamous-cell-carcinomas-to-anti-pd1-monoclonal-antibody-regn2810
#7
Gerald S Falchook, Rom Leidner, Elizabeth Stankevich, Brian Piening, Carlo Bifulco, Israel Lowy, Matthew G Fury
BACKGROUND: Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (CSCC) share exposure to UV light as the dominant risk factor, and these tumors therefore harbor high mutation burdens. In other malignancies, high mutation burden has been associated with clinical benefit from therapy with antibodies directed against the Programmed Death 1 (PD-1) immune checkpoint receptor. Highly mutated tumors are more likely to express immunogenic tumor neoantigens that attract effector T cells, which can be unleashed by blockade of the PD-1 immune checkpoint...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27878063/retrospective-study-of-punch-scoring-versus-freehand-approach-for-first-stage-mohs-micrographic-surgery
#8
Nikoo Cheraghi, Abdulhadi Jfri, Robert Bacigalupi, Hooman Khorasani
Objective: The objective was to observe whether there is a difference in the number of subjects requiring more than one stage of Mohs micrographic surgery for small lesion nonmelanoma skin cancers using the punch scoring method versus freehand approach. Design: Retrospective review. Setting: Outpatient Mohs Clinic. Participants: Thirty patients with small lesion (<5mm) basal cell and squamous cell carcinoma who had Mohs micrographic surgery using either the punch scoring method (15) for scoring the first layer or the freehand method (15)...
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27876303/rapid-visualization-of-nonmelanoma-skin-cancer
#9
Ethan Walker, Margaret Mann, Kord Honda, Allison Vidimos, Mark D Schluchter, Brian Straight, Matthew Bogyo, Daniel Popkin, James P Basilion
BACKGROUND: Mohs micrographic surgery examines all margins of the resected sample and has a 99% cure rate. However, many nonmelanoma skin cancers (NMSCs) are not readily amenable to Mohs micrographic surgery. This defines an unmet clinical need to assess the completeness of non-Mohs micrographic surgery resections during surgery to prevent re-excision/recurrence. OBJECTIVE: We sought to examine the utility of quenched activity-based probe imaging to discriminate cancerous versus normal-appearing skin tissue...
November 19, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27875372/cutaneous-malignancies-in-hiv
#10
Aileen Y Chang, Phil Doiron, Toby Maurer
PURPOSE OF REVIEW: As patients with HIV infection are living longer with their disease, we have seen the evolution of skin cancer in this population. Cancer registries have not documented the incidence and prevalence of these cancers but we do have relevant data from cohorts. This article attempts to bring to light the extent to which skin cancer is an issue in HIV disease both domestically and internationally. RECENT FINDINGS: Squamous cell cancer is increasing in incidence in the United States and elsewhere...
January 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/27869450/basal-cell-carcinoma-of-the-skin-with-mixed-histomorphology-a%C3%A2-comparative-study
#11
Vladimír Bartoš, Milada Kullová
Basal cell carcinoma (BCC) of the skin exhibits a very heterogeneous histomorphology, on the basis of which it is classified into several subtypes and variants. In many cases, however, a definite categorization remains difficult, because BCC may consist of more than one histopathological subtype. There are limited data exploring the characteristics of these mixed BCCs, since they have not been specifically analysed. The aim of this study was to estimate the prevalence of BCCs with mixed histomorphology observed in a set of primary BCCs and to compare their clinicopathological features with a single type BCC subgroup...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27860083/dermoscopic-monitoring-of-efficacy-of-ingenol-mebutate-in-the-treatment-of-pigmented-and-non-pigmented-basal-cell-carcinomas
#12
Laura Diluvio, Mauro Bavetta, Monia Di Prete, Augusto Orlandi, Luca Bianchi, Elena Campione
Basal cell carcinoma is the most common non-melanoma skin cancer, and its incidence continues to raise. Although surgery can be considered the mainstay of therapy, new current pharmacological options are available and focus on tumor eradication, maximizing cosmetic results, and functional capacity. Several studies have recently reported on safety and efficacy of topical ingenol mebutate gel, a derivative of the plant Euphorbia Peplus, used to treat actinic keratosis and superficial basal cell carcinoma. In our knowledge, we report for the first time the dermoscopic evaluation of outcome and monitoring of superficial pigmented and non-pigmented basal cell carcinomas in four patients treated by this novel non-ablative agent...
November 12, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27848425/skin-cancer
#13
Lisa Berry
Essential facts Skin cancer can be split into 2 groups: malignant melanoma, which can be fatal; and non-melanoma, such as squamous cell carcinoma and basal cell carcinomas, which are rarely lethal. In 2013 there were 14,509 new cases of malignant melanoma in the UK and, in 2014, 2,459 people died from the disease. Non-melanoma skin cancers are more common; 72,100 new cases were diagnosed in the UK in 2013.
November 9, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27846199/height-height-related-snps-and-risk-of-non-melanoma-skin-cancer
#14
Xin Li, Liming Liang, Yen-Chen Anne Feng, Immaculata De Vivo, Edward Giovannucci, Jean Y Tang, Jiali Han
BACKGROUND: Adult height has been associated with risk of several site-specific cancers, including melanoma. However, less attention has been given to non-melanoma skin cancer (NMSC). METHODS: We prospectively examined the risk of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) in relation to adult height in the Nurses' Health Study (NHS, n=117 863) and the Health Professionals Follow-up Study (HPFS, n=51 111). We also investigated the relationships between height-related genetic markers and risk of BCC and SCC in the genetic data sets of the NHS and HPFS (3898 BCC cases, and 8530 BCC controls; 527 SCC cases, and 8962 SCC controls)...
November 15, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27837157/case-report-of-patient-with-erythropoietic-protoporphyria-and-basal-cell-carcinoma-diagnoses
#15
Shayne D Reitmeier, Brent Schacter, Marni C Wiseman
BACKGROUND: Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer. There is a clear association between BCC development and ultraviolet (UV) radiation. Erythropoietic protoporphyria (EPP) is an inherited porphyria disorder that is a result of protoporphyrin accumulation, typically manifesting with phototoxicity. CASE SUMMARY: We report a case of a 24 year-old man with both EPP and BCC diagnoses. At the age of 4 years, the patient was diagnosed with EPP...
November 11, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27830172/an-unusual-case-of-basal-cell-carcinoma-of-the-vulva-with-lung-metastases
#16
G A Watson, D Kelly, L Prior, E Stanley, O MacEneaney, T Walsh, C M Kelly
Basal cell carcinoma (BCC) is the most common non-melanomatous skin cancer, typically arising in sun-exposed areas such as the head and neck. Defective signaling through the Hedgehog (HH) signaling pathway forms the molecular basis for BCC. Surgery remains the mainstay of treatment. Basal cell carcinoma of the genital tract is rare as is metastatic BCC. We report a case of metastatic BCC in a young woman with previously resected vulval BCC presenting six years later with inguinal nodal recurrence and multiple lung metastases...
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27828631/expression-of-heparanase-in-basal-cell-carcinoma-and-squamous-cell-carcinoma
#17
Maria Aparecida Silva Pinhal, Maria Carolina Leal Almeida, Alessandra Scorse Costa, Thérèse Rachell Theodoro, Rodrigo Lorenzetti Serrano, Carlos D'Apparecida Santos Machado
Background: Heparanase is an enzyme that cleaves heparan sulfate chains. Oligosaccharides generated by heparanase induce tumor progression. Basal cell carcinoma and squamous cell carcinoma comprise types of nonmelanoma skin cancer. Objectives: Evaluate the glycosaminoglycans profile and expression of heparanase in two human cell lines established in culture, immortalized skin keratinocyte (HaCaT) and squamous cell carcinoma (A431) and also investigate the expression of heparanase in basal cell carcinoma, squamous cell carcinoma and eyelid skin of individuals not affected by the disease (control)...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27825428/diagnostic-and-therapeutic-strategies-for-prostate-cancer
#18
REVIEW
Mary Nguyen-Nielsen, Michael Borre
Prostate cancer (PC) is a major disease that affects men's health worldwide. It is the second most common form of cancer in men, surpassed only by nonmelanoma skin cancers such as basal and squamous cell carcinomas. Diagnostic strategies with population screening for prostate cancer using prostate-specific antigen (PSA) has been surrounded with controversy and debated intensively ever since the PSA protein was first purified in 1979 by Wang et al. At the same time, advances in diagnostic imaging, surgery, radiation, and chemotherapy have increased the opportunity to effectively diagnose, treat, and manage PC...
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27822110/the-danish-nonmelanoma-skin-cancer-dermatology-database
#19
REVIEW
Anna Lei Lamberg, Henrik Sølvsten, Ulrikke Lei, Gabrielle Randskov Vinding, Ida Marie Stender, Gregor Borut Ernst Jemec, Tine Vestergaard, Henrik Thormann, Merete Hædersdal, Tomas Norman Dam, Anne Braae Olesen
AIM OF DATABASE: The Danish Nonmelanoma Skin Cancer Dermatology Database was established in 2008. The aim of this database was to collect data on nonmelanoma skin cancer (NMSC) treatment and improve its treatment in Denmark. NMSC is the most common malignancy in the western countries and represents a significant challenge in terms of public health management and health care costs. However, high-quality epidemiological and treatment data on NMSC are sparse. STUDY POPULATION: The NMSC database includes patients with the following skin tumors: basal cell carcinoma (BCC), squamous cell carcinoma, Bowen's disease, and keratoacanthoma diagnosed by the participating office-based dermatologists in Denmark...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27795755/metastatic-giant-basal-cell-carcinoma-a-case-report
#20
Khadija Bellahammou, Asmaa Lakhdissi, Othman Akkar, Fadoua Rais, Benhmidou Naoual, Ibrahim Elghissassi, Hind M'rabti, Hassan Errihani
Basal cell carcinoma is the most common skin cancer, characterised by a slow growing behavior, metastasis are extremely rare, and it occurs in less than 0, 1% of all cases. Giant basal cell carcinoma is a rare form of basal cell carcinoma, more aggressive and defined as a tumor measuring more than 5 cm at its largest diameter. Only 1% of all basal cell carcinoma develops to a giant basal cell carcinoma, resulting of patient's negligence. Giant basal cell carcinoma is associated with higher potential of metastasis and even death, compared to ordinary basal cell carcinoma...
2016: Pan African Medical Journal
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