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https://www.readbyqxmd.com/read/28414587/non-melanoma-skin-cancer-new-and-future-synthetic-drug-treatments
#1
Teresa Amaral, Claus Garbe
Non-melanoma skin cancers (NMSC) mainly comprise two different entities: basal cell carcinoma (BCC) and squamous cell carcinoma (SCC); beneath these two entities, Merkel cell carcinoma, adnexal tumors, dermatofibrosarcoma protuberans, angiosarcoma, and cutaneous lymphoma belong to NMSC. These rare skin tumors are not the topic of this review. BCC and SCC are the most common cancers diagnosed in humans. The preferred treatment is surgery, which in most cases is curative. Although a high recurrence rate is seen, these cancers rarely metastasize...
April 17, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28414022/cigarette-smoking-and-the-risks-of-basal-cell-carcinoma-and-squamous-cell-carcinoma
#2
J C Dusingize, C M Olsen, N P Pandeya, P Subramaniam, B S Thompson, R E Neale, A C Green, D C Whiteman
Sunlight is the principal environmental risk factor for keratinocyte cancers, but other carcinogens have also been implicated, including tobacco smoke. Findings have been conflicting however. We investigated associations between cigarette smoking and incidence of BCC or SCC in QSkin, a prospective study of skin cancer (n=43,794). Smoking history was self-reported at baseline; newly diagnosed BCCs and SCCs were ascertained through data linkage and verified by histopathology reports. We restricted analyses to white participants who at baseline reported no past history of skin cancer excisions and no more than 5 destructively-treated actinic skin lesions...
April 13, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28408001/cost-effectiveness-analysis-of-a-skin-awareness-intervention-for-early-detection-of-skin-cancer-targeting-men-older-than-50-years
#3
Louisa G Gordon, Joshua Brynes, Peter D Baade, Rachel E Neale, David C Whiteman, Philippa H Youl, Joanne F Aitken, Monika Janda
OBJECTIVES: To assess the cost-effectiveness of an educational intervention encouraging self-skin examinations for early detection of skin cancers among men older than 50 years. METHODS: A lifetime Markov model was constructed to combine data from the Skin Awareness Trial and other published sources. The model incorporated a health system perspective and the cost and health outcomes for melanoma, squamous and basal cell carcinomas, and benign skin lesions. Key model outcomes included Australian costs (2015), quality-adjusted life-years (QALYs), life-years, and counts of skin cancers...
April 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28400895/melanoma-and-basal-cell-carcinoma-in-the-hereditary-leiomyomatosis-and-renal-cell-cancer-syndrome-an-expansion-of-the-oncologic-spectrum
#4
Lacy L Sommer, Rhonda E Schnur, Warren R Heymann
BACKGROUND: Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) is an autosomal dominant syndrome due to mutation in fumarate hydratase. Patients with HLRCC frequently develop cutaneous and uterine leiomyomata and are at risk for renal cell carcinoma. Rarely, other malignancies have been reported. MAIN OBSERVATIONS: We report the development of basal cell carcinoma and melanoma in two siblings with genetically-confirmed HLRCC. CONCLUSIONS: It is unclear whether the development of melanoma and basal cell carcinoma in our patients is due directly to their mutations in the gene encoding fumarate hydratase, or genetic susceptibility at another unrelated locus, or whether these are incidental lesions...
November 30, 2016: Journal of Dermatological Case Reports
https://www.readbyqxmd.com/read/28399340/what-s-new-in-eyelid-tumors
#5
Nora Silverman, Roman Shinder
Eyelid malignancies represent between 5% and 10% of all skin cancers. Basal cell carcinoma is the most common, followed by squamous cell carcinoma, sebaceous cell carcinoma, Merkel cell carcinoma, and melanoma. The gold standard treatment for periocular epithelial malignancies is surgical excision. Given the constraints of the anatomy and function of the eyelids, excision with negative margins and reconstruction can be challenging. In cases of significant tissue invasion or metastasis, complete tumor removal may not be possible...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28396790/paul-of-aegina-ca-625-690-ad-an-early-description-of-a-rare-basal-cell-carcinoma-of-the-breast
#6
Gregory Tsoucalas, Markos Sgantzos
Basal cell carcinoma of the breast is a rare type of skin cancer. A probable case reported c.650AD is described with very similar localized symptoms. Understanding its emergence and evolution could improve diagnosis and treatment.
April 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28381343/podoplanin-expression-in-peritumoral-keratinocytes-predicts-aggressive-behavior-in-extramammary-paget-s-disease
#7
Zaigen Cho, Eiichi Konishi, Mai Kanemaru, Taro Isohisa, Takahiro Arita, Minako Kawai, Miho Tsutsumi, Hiromi Mizutani, Hideya Takenaka, Toshiyuki Ozawa, Daisuke Tsuruta, Norito Katoh, Jun Asai
BACKGROUND: Recent studies have demonstrated podoplanin expression in several tumors, which has been associated with lymph node metastasis and poor prognosis. Podoplanin expression in peritumoral cells such as cancer-associated fibroblasts also correlates with tumor progression in several cancers. However, podoplanin expression and its association with extramammary Paget's disease (EMPD) remain unclear. OBJECTIVE: In this study, we examined whether the presence of podoplanin expression in tumor cells or peritumoral basal keratinocytes correlated with aggressive behavior in patients with EMPD and investigated the mechanisms of podoplanin-mediated tumor invasion in this disorder...
March 27, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28376160/history-of-keratinocyte-carcinoma-and-risk-of-melanoma-a-prospective-cohort-study
#8
Shaowei Wu, Eunyoung Cho, Wen-Qing Li, Abrar A Qureshi
Background: The association between history of keratinocyte carcinoma (KC, also known as nonmelanoma skin cancer) and risk of developing invasive melanoma has not been assessed comprehensively using prospective data. Methods: We followed 91 846 women in the Nurses' Health Study (NHS; 1984-2010), 114 918 women in the NHSII (1989-2011), and 48 946 men in the Health Professionals Follow-up Study (1986-2010) for diagnoses of KC and melanoma biennially. Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) of melanoma associated with history of KC, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC)...
April 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28373119/photodynamic-therapy-effective-for-the-treatment-of-actinic-keratosis-and-basal-cell-carcinoma-in-bullous-pemphigoid-patients
#9
Theresa N Canavan, Salma Faghri de la Feld, Conway Huang, Naveed Sami
Treating skin cancers and extensive actinic keratosis in patients with bullous pemphigoid (BP) can be challenging. Treatment options pose unique risks in these patients as surgical wounds can have delayed wound healing and photodynamic therapy (PDT) may exacerbate their blistering disease. We report the successful use of PDT to treat actinic keratosis and skin cancers in two patients with BP, both of whom had excellent response to PDT and tolerated treatment without any bullous disease flares. Carefully selected patients with skin cancers and stable, well controlled BP can be safely considered for treatment using PDT...
March 31, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28368419/%C3%AE-np63%C3%AE-promotes-adhesion-of-metastatic-prostate-cancer-cells-to-the-bone-through-regulation-of-cd82
#10
V Di Giacomo, T V Tian, A Mas, M Pecoraro, L Batlle-Morera, L Noya, J Martín-Caballero, J Ruberte, W M Keyes
ΔNp63α is a critical mediator of epithelial development and stem cell function in a variety of tissues including the skin and breast, while overexpression of ΔNp63α acts as an oncogene to drive tumor formation and cancer stem cell properties in squamous cell carcinoma. However, with regards to the prostate, while ΔNp63α is expressed in the basal stem cells of the mature gland, during adenocarcinoma development, its expression is lost and its absence is used to clinically diagnose the malignant state. Surprisingly, here we identify a sub-population of bone metastatic prostate cancer cells in the PC3 cell line that express ΔNp63α...
April 3, 2017: Oncogene
https://www.readbyqxmd.com/read/28361252/-single-center-analysis-of-the-dermatosurgical-patient-cohort-of-a%C3%A2-tumor-center-in-germany
#11
A Lobeck, C Weiss, A Orouji, P-S Koch, M Heck, J Utikal, W Koenen, J Faulhaber, C-D Klemke, M Felcht
BACKGROUND: The incidence of skin cancer continues to increase. However, little is known about the dermatosurgical characteristics of the patients. PATIENTS AND METHODS: In this single center, retrospective study, dermatosurgical reports of all patients treated because of basal cell carcinomas (BCC), squamous cell carcinomas (SCC), and malignant melanoma (MM) between 2004 and 2013 were analyzed. RESULTS: During the observed period, the number of operated BCC rose by a factor of 1...
March 30, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28358170/shift-in-occupational-risk-for-basal-cell-carcinoma-from-outdoor-to-indoor-workers-a-large-population-based-case-control-register-study-from-sweden
#12
Bernt Lindelöf, Jan Lapins, Henrik Dal
Basal cell carcinoma (BCC) is the most common form of cancer worldwide. Exposure of the skin to ultraviolet (UV) radiation, from sunlight and other sources, is the most important risk factor. The aim of this large-scale case-control study was to determine which occupations are associated with increased risk of BCC in Sweden. The case cohort comprised 74,247 patients with BCC and the control cohort comprised 574,055 subjects linked to population-based registers. Compared with the occupational category of farmers, foresters and gardeners we observed elevated risks of BCC for almost all occupational categories studied...
March 30, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28346486/grem1-is-expressed-in-the-cancer-associated-myofibroblasts-of-basal-cell-carcinomas
#13
Hye Sung Kim, Myung Soo Shin, Min Seok Cheon, Jae Wang Kim, Cheol Lee, Woo Ho Kim, Young Sill Kim, Bo Gun Jang
Cancer-associated fibroblasts (CAFs) play important roles in cancer progression through their complex interactions with cancer cells. The secreted bone morphogenetic protein antagonist, gremlin1 (GREM1) is expressed by the CAFs of basal cell carcinomas (BCCs), and promotes the growth of cancer cells. In this study, we investigated the expression of GREM1 mRNAs in various benign and malignant skin tumors, including various BCC subtypes. Analysis by RNA in situ hybridization (ISH) revealed that fibroblasts in the scar tissue expressed GREM1 and α-smooth muscle actin (α-SMA), whereas resident fibroblasts in the dermis of the normal skin did not express GREM1...
2017: PloS One
https://www.readbyqxmd.com/read/28344599/does-ultrasound-measurement-improve-the-accuracy-of-electronic-brachytherapy-in-the-treatment-of-superficial-non-melanomatous-skin-cancer
#14
Uma Goyal, Junhan Pan, Haiyan Cui, Baldassarre Stea
PURPOSE: Electronic brachytherapy (eBT) is a form of contact radiation therapy used for thin superficial non-melanomatous skin cancers (NMSCs). An accurate measurement of diameter and depth is important for eBT treatment planning. Therefore, we compared clinical measurements by an experienced physician to measurements obtained using ultrasound (US), an objective imaging modality, in order to determine if clinical measurements were accurate enough for adequate NMSC treatment. MATERIAL AND METHODS: Eighteen patients with 20 biopsy-proven NMSCs first had a clinical examination and then an US evaluation prior to starting eBT...
February 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28343197/-skin-cancers-in-kidney-transplant-recipients
#15
Anna Bieryło, Szymon Brzósko, Elżbieta Laudańska, Beata Naumnik
Kidney transplantation is the best treatment for end-stage renal failure. It prolongs the patient's life, improves quality of life and reduces costs associated with renal replacement therapy. Increasingly, newer immunosuppressive regimens allow for the proper functioning of the transplanted organ for many years. The progress in transplantation, qualification patients in older age for the procedure and longer survival of kidney graft lead to an increase in the number of patients receiving immunosuppressive drugs...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28342067/the-incidence-of-post-transplant-cancer-among-kidney-transplant-recipients-is-associated-with-the-level-of-tacrolimus-exposure-during-the-first-year-after-transplantation
#16
Shelly Lichtenberg, Ruth Rahamimov, Hefziba Green, Benjamin D Fox, Eytan Mor, Uzi Gafter, Avry Chagnac, Benaya Rozen-Zvi
PURPOSE: Immunosuppressive therapy plays a major role in the development of post-transplant cancer. In this nested case-control study of kidney transplant recipients (KTRs), we investigated whether the incidence of post-transplant cancer is associated with the level of tacrolimus exposure over time. METHODS: We screened the Rabin Medical Center database for adults who received kidney transplants between 2001 and 2014 and developed post-transplant cancer (excluding basal and squamous cell skin cancers)...
March 24, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28329666/risks-of-different-skin-tumor-combinations-after-a-first-melanoma-squamous-cell-carcinoma-and-basal-cell-carcinoma-in-dutch-population-based-cohorts-1989-2009
#17
R J T Van der Leest, L M Hollestein, L Liu, T Nijsten, E De Vries
The aim of this study was to calculate risks of different type of subsequent skin cancers.All melanoma and squamous cell carcinoma (SCC) patients included in the national Netherlands Cancer Registry (NCR) and all basal cell carcinoma (BCC) patients included in the regional Eindhoven Cancer Registry (ECR) between 1989 and 2009 were followed until diagnosis of a subsequent different skin cancer (melanoma, SCC or BCC), date of death or end of study. Cumulative risk, Standardized Incidence Ratio (SIR) and Absolute Excess Risk (AER) of subsequent skin cancers were calculated...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329660/predictors-of-tanning-dependence-in-white-non-hispanic-females-and-males
#18
Brenda Cartmel, Susan T Mayne, Allen E Bale, Joel Gelernter, Andrew DeWan, David J Leffell, Sherry Pagoto, Peter Spain, Leah M Ferrucci
Growing evidence suggests some individuals may exhibit dependence to ultraviolet light, a known carcinogen; however, few studies have investigated predictors of tanning dependence (TD).A sub-set of early-onset basal cell carcinoma case-control study participants completed an online survey. The modified-Cut down, Annoyed, Guilty, Eye-opener (mCAGE) and a questionnaire based on the addiction criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (mDSM-IV-TR) were used to classify participants having'Symptoms of TD' if they met criteria for TD on both questionnaires, 'Tendency for TD' if met criteria on only one questionnaire, or 'Not TD'...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329648/hormonal-and-reproductive-factors-and-incidence-of-basal-cell-carcinoma-in-a-population-based-cohort
#19
Catherine M Olsen, Nirmala Pandeya, Bridie S Thompson, Jean Claude Dusingize, Padmini Subramaniam, Christina M Nagle, Adele C Green, Rachel E Neale, Penny M Webb, David C Whitman
Estrogens have photosensitizing properties, but few prospective studies have examined the relationship between hormonal and reproductive factors and incidence of basal cell carcinoma (BCC) in women. Previous findings have been inconsistent, particularly in relation to parity and use of oral contraceptives (OCs) and menopausal hormone therapy (MHT). Given the heterogeneity in the literature, we sought to examine the association between hormonal and reproductive factors and BCC risk in a cohort of women (n=23,879) enrolled in the QSkin Study in 2011...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329632/cigarette-smoking-and-the-risks-of-incident-basal-cell-carcinoma-and-squamous-cell-carcinoma-in-a-large-population-based-cohort-study
#20
Jean Claude Dusingize, Catherine M Olsen, Nirmala Pandeya, Bridie Thompson, Rachel E Neale, Padmini Subramaniam, David C Whiteman, Adele C Green
Tobacco smoking is a strong risk factor for cancer, but associations with basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) of the skin have been inconsistent. We prospectively investigated the associations between cigarette smoking and 3-year incidence of first primary BCC or SCC in the QSkin cohort (n=43765). Smoking history was self-reported at baseline; newly diagnosed and surgically treated BCCs and SCCs were ascertained through linkage to the national health insurance scheme and verified by histopathology reports...
September 15, 2016: Dermatology Online Journal
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