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https://www.readbyqxmd.com/read/28212537/itraconazole-exerts-its-anti-melanoma-effect-by-suppressing-hedgehog-wnt-and-pi3k-mtor-signaling-pathways
#1
Guanzhao Liang, Musang Liu, Qiong Wang, Yongnian Shen, Huan Mei, Dongmei Li, Weida Liu
Malignant melanoma is the deadliest form of all skin cancers. Itraconazole, a commonly used systemic antifungal drug, has been tested for its anti-tumor effects on basal cell carcinoma, prostate cancer, and non-small cell lung cancer. Whether itraconazole has any specific anti-tumor effect on melanoma remains unknown. However, the goal of this study is to investigate the effect of itraconazole on melanoma and to reveal some details of its underlying mechanism. In the in vivo xenograft mouse model, we find that itraconazole can inhibit melanoma growth and extend the survival of melanoma xenograft mice, compared to non-itraconazole-treated mice...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28210385/high-dose-rate-electronic-brachytherapy-a-nonsurgical-treatment-alternative-for-nonmelanoma-skin-cancer
#2
REVIEW
Ajay Bhatnagar, Rakesh Patel, William Philip Werschler, Roger I Ceilley, Robert Strimling
The authors summarized data from a group of physicians with experience using high-dose rate electronic brachytherapy for the treatment of nonmelanoma skin cancer. The data have been published or presented in abstract format at national dermatology and radiation oncology meetings. The data included 1,822 treated lesions from 2009 to 2014 in patients ranging in age from 52 to 104 years. Most lesions were basal cell carcinoma (57%) or squamous cell carcinoma (38%) less than 2cm in size (97%). Median follow-up at the various centers ranged from 4 to 16 months, and results yielded an extremely low recurrence rate of less than one percent...
November 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28196178/association-of-human-papillomavirus-vaccine-with-the-development-of-keratinocyte-carcinomas
#3
Anna J Nichols, Amber Heyna Allen, Shahjahan Shareef, Evangelos V Badiavas, Robert S Kirsner, Tim Ioannides
Importance: Keratinocyte carcinomas (KCs), consisting of squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs), are the most common human malignant neoplasms. Several risk factors have been implicated in KC development. For some SCCs, particularly those in immunocompromised patients, human papillomavirus (HPV) may be an important factor. Objective: To determine whether quadrivalent HPV vaccination would affect the development of KCs in immunocompetent patients with a history of multiple KCs...
February 8, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28195845/an-analysis-of-laser-therapy-for-the-treatment-of-nonmelanoma-skin-cancer
#4
Teo Soleymani, Michael Abrouk, Kristen M Kelly
BACKGROUND: Skin cancer remains the most prevalent type of cancer in the United States, and its burden on the health care system remains substantial. Standard treatments such as cryosurgery, electrodessication and curettage, topical and photodynamic therapies, and surgical excision including Mohs micrographic surgery are not without inherent morbidity, including risk of bleeding, infection, and scar. OBJECTIVE: Lasers may be an alternative for treatment of nonmelanoma skin cancer, and this paper reviews this therapeutic option...
February 9, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28195452/practical-indications-for-the-management-of-non-melanoma-skin-cancer-patients
#5
Alessandro DI Stefani, Laura Del Regno, Alfredo Piccerillo, Ketty Peris
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), together encompassed in the term non--melanoma skin cancers (NMSC), are the most common cancers among fair--skinned populations. Individuating accurate risk stratification of NMSC patients is crucial to select different options among various treatment strategies. The majority of low risk NMSCs are easily treated with surgery, offering excellent cure rates and cosmetic results. Other treatment modalities include physical destruction (curettage, cautery and cryotherapy), chemical destruction (photodynamic therapy and topical 5--flurouracil) and immunomodulatory therapy (topical imiquimod)...
February 14, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28194541/undermining-plastic-surgery-as-a%C3%A2-possible-option-for-treating-basal-cell-carcinoma-of-the-forehead
#6
Georgi Tchernev, Ivan Pidakev, Ilia Lozev, Torello Lotti, Jose Carlos Cardoso, James W Patterson
Basal cell carcinoma (BCC) is the most common cutaneous cancer. Although most cases can be cured with simple surgical procedures and are associated with a good prognosis, a minority of BCCs may pose significant therapeutic challenges. This occurs mostly in cases of so-called advanced BCC, which a loosely defined term that encompasses locally advanced lesions and tumors with metastatic spread. Treatment of these cases is often complex and sometimes may need combinations of therapeutic modalities, including surgery, radiotherapy and/or targeted therapy directed towards sonic hedgehog (SHH) signaling pathways, such as vismodegib...
February 13, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28193642/basal-cell-carcinoma-arising-in-a-congenital-melanocytic-naevus-in-an-adult
#7
Lillian Cooper, Karthik Srinivasan, Nora Nugent
Congenital melanocytic naevi (CMN) are common skin lesions. They harbour a risk of malignant transformation, and various lesions have been described as developing within them. A basal cell cancer occurring within a CMN has never previously been described. A case is described of a woman aged 52 years presenting with a slow-growing, symptomatic 3 cm lesion in the centre of a 10×5 cm CMN on her right upper back. Diagnostic core biopsy revealed an ulcerated, infiltrative basal cell carcinoma which was then further excised...
February 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28187958/expression-of-oncogenic-mir-17-92-and-tumor-suppressive-mir-143-145-clusters-in-basal-cell-carcinoma-and-cutaneous-squamous-cell-carcinoma
#8
Michael Sand, Schapoor Hessam, Susanne Amur, Marina Skrygan, Michael Bromba, Eggert Stockfleth, Thilo Gambichler, Falk G Bechara
BACKGROUND: A variety of cancers are associated with the expression of the oncogenic miR-17-92 cluster (Oncomir-1) and tumor suppressor miR-143-5p/miR-145-5p. Epidermal skin cancer has not been investigated for the expression of miR-17-92 and miR-143-145 clusters, despite being extensively studied regarding global microRNA profiles. The goal of this study was to investigate the expression and possible correlation of expression of miR17-92 and miR-143-145 cluster members in epidermal skin cancer...
January 31, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28178758/incidence-of-lip-malignancies-in-germany-data-from-9-population-based-cancer-registries
#9
S Singer, S R Zeissig, K Emrich, B Holleczek, K Kraywinkel, M Ressing
BACKGROUND: The objective of this study was to analyse the incidence of lip malignancies in Germany. METHODS: Data from population-based cancer registries covering a population of 39 million inhabitants from 14 federal states were pooled. Lip malignancies were classified according to the International Classification of Diseases (ICD-10). Age-standardised incidence rates and annual percentage changes in the incidence trends of lip cancer (C00), melanoma of the lip (C43...
February 8, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28161328/energy-metabolism-in-skin-cancers-a-therapeutic-perspective
#10
REVIEW
Mohsen Hosseini, Zeinab Kasraian, Hamid Reza Rezvani
Skin cancers are the most common cancers worldwide. The incidence of common skin cancers, including basal cell carcinomas (BCCs), squamous cell carcinoma (SCC) and melanomas, continues to rise by 5 to 7% per year, mainly due to ultraviolet (UV) exposure and partly because of aging. This suggests an urgent necessity to improve the level of prevention and protection for skin cancers as well as developing new prognostic and diagnostic markers of skin cancers. Moreover, despite innovative therapies especially in the fields of melanoma and carcinomas, new therapeutic options are needed to bypass resistance to targeted therapies or treatment's side effects...
February 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28158294/deep-proteome-mapping-of-wm-266-4-human-metastatic-melanoma-cells-from-oncogenic-addiction-to-druggable-targets
#11
Eumorphia G Konstantakou, Athanassios D Velentzas, Athanasios K Anagnostopoulos, Zoi I Litou, Ourania A Konstandi, Aikaterini F Giannopoulou, Ema Anastasiadou, Gerassimos E Voutsinas, George Th Tsangaris, Dimitrios J Stravopodis
Cutaneous melanoma is a malignant tumor of skin melanocytes that are pigment-producing cells located in the basal layer (stratum basale) of epidermis. Accumulation of genetic mutations within their oncogenes or tumor-suppressor genes compels melanocytes to aberrant proliferation and spread to distant organs of the body, thereby resulting in severe and/or lethal malignancy. Metastatic melanoma's heavy mutational load, molecular heterogeneity and resistance to therapy necessitate the development of novel biomarkers and drug-based protocols that target key proteins involved in perpetuation of the disease...
2017: PloS One
https://www.readbyqxmd.com/read/28152902/the-standardization-of-skin-cancer-treatment-recommendations-through-the-analysis-of-clinical-pathways-data-and-an-evidence-based-physician-driven-committee-process
#12
Amanda Barry, Hans Benson, Zach Lorinc, Kathleen Lokay
: 147 Background: Clinical pathways (CP) have the potential to improve the quality and safety of care and lead to more predictable outcomes and costs through standardization. Via Oncology's CP program aims to standardize care at radiation centers across its nationwide network. Created through an evidence-based, physician-driven committee process, CP recommend the best treatment plan for specific patient populations based on a hierarchy of efficacy, toxicity, and cost. In the absence of definitive data, reaching a consensus on the best treatment recommendation is difficult, particularly for disease states such as melanoma, squamous cell carcinoma, and basal cell carcinoma for which a wide range of radiation doses and schedules are considered effective and regional and institutional preferences may vary...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152570/niacin-intake-and-risk-of-skin-cancer-in-us-women-and-men
#13
Sang Min Park, Tricia Li, Shaowei Wu, Wen-Qing Li, Martin Weinstock, Abrar A Qureshi, Eunyoung Cho
A recent clinical trial found a protective role of niacinamide, a derivative of niacin, against skin cancer recurrence. However, there is no epidemiologic study to assess the association between niacin intake and risk of skin cancer (basal cell carcinoma [BCC], squamous cell carcinoma [SCC], and melanoma). We prospectively evaluated whether total, dietary and supplemental niacin intake was associated with skin cancer risk based on 72,308 women in the Nurses' Health Study (1984-2010) and 41,808 men in the Health Professionals Follow-up Study (1986-2010)...
February 2, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28139027/sun-protection-for-preventing-basal-cell-and-squamous-cell-skin-cancers
#14
REVIEW
Kate Rowan-Robinson
Review question: What is the most effective form of sun protection (including sunscreens) to prevent basal cell carcinoma and cutaneous squamous cell carcinoma of the skin?
January 31, 2017: Public Health Nursing
https://www.readbyqxmd.com/read/28125038/arsenic-induces-p62-expression-to-form-a-positive-feedback-loop-with-nrf2-in-human-epidermal-keratinocytes-implications-for-preventing-arsenic-induced-skin-cancer
#15
Palak Shah, Elaine Trinh, Lei Qiang, Lishi Xie, Wen-Yang Hu, Gail S Prins, Jingbo Pi, Yu-Ying He
Exposure to inorganic arsenic in contaminated drinking water poses an environmental public health threat for hundreds of millions of people in the US and around the world. Arsenic is a known carcinogen for skin cancer. However, the mechanism by which arsenic induces skin cancer remains poorly understood. Here, we have shown that arsenic induces p62 expression in an autophagy-independent manner in human HaCaT keratinocytes. In mouse skin, chronic arsenic exposure through drinking water increases p62 protein levels in the epidermis...
January 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28115960/non-melanoma-skin-cancer-treated-with-high-dose-rate-brachytherapy-a-review-of-literature
#16
REVIEW
Durim Delishaj, Agata Rembielak, Bruno Manfredi, Stefano Ursino, Francesco Pasqualetti, Concetta Laliscia, Francesca Orlandi, Riccardo Morganti, Maria Grazia Fabrini, Fabiola Paiar
PURPOSE: The incidence of non-melanoma skin cancer (NMSC) has been increasing over the past 30 years. There are different treatment options and surgical excision is the most frequent treatment due to its low rates of recurrence. Radiotherapy is an effective alternative of surgery, and brachytherapy (BT) might be a better therapeutic option due to high radiation dose concentration to the tumor with rapid dose fall-off resulting in normal tissues sparing. The aim of this review was to evaluate the local control, toxicity, and cosmetic outcomes in NMSC treated with high-dose-rate BT (HDR-BT)...
December 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28112098/primary-cutaneous-malignancies-in-the-northern-cape-province-of-south-africa-a-retrospective-histopathological-review
#17
K York, N C Dlova, C Y Wright, N P Khumalo, P E Kellett, R Kassanjee, A Mosam
BACKGROUND: Excessive sun exposure and a high prevalence of HIV increase skin cancer risk in South Africa (SA). OBJECTIVE: To describe the nature and extent of skin cancers presenting in the public and private health sectors of the Northern Cape Province of SA. METHODS: A retrospective analysis of histologically confirmed new primary cutaneous malignancies from 1 January 2008 to 31 December 2012 was conducted using public and private health sector databases...
December 21, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28087048/-characteristics-and-risk-factors-for-recurrence-of-cutaneous-squamous-cell-carcinoma-with-conventional-surgery-and-surgery-with-delayed-intraoperative-margin-assessment
#18
Judith Domínguez-Cherit, Georgina Rodríguez-Gutiérrez, Verónica Narváez Rosales, Sonia Toussaint Caire, Verónica Fonte Avalos
BACKGROUND: Non-melanoma skin cancer includes basal cell carcinoma and squamous cell carcinoma (SCC). Basal cell carcinoma is the most common and least aggressive but in a low percentage of cases, despite appropriate wide surgical margins, it can be aggressive, producing local invasion, recurrences and distance metastasis. SCC has a more aggressive behaviour invading first the skin, the lymph nodes and less frequently produces distance metastasis OBJECTIVE: To identify the characteristics of recurrent SCC and frequency of new SCC after conventional surgical and primary closure or closure delayed until a histological reporting of tumour-free surgical margins, in order to achieve a better surgical option, in our Mexican population...
January 10, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28076343/pigmented-basal-cell-carcinoma-mimicking-a-superficial-spreading-melanoma
#19
Paula Hasbún Acuña, Roberto Cullen Aravena, César Maturana Donaire, Raúl Ares Mora, Ninoska Porras Kusmanic
Basal cell carcinoma is the most common form of skin cancer, especially in elderly people. Pigmented basal cell carcinoma is a rare subtype and has been described in the literature as a nodular and hyperpigmented lesion; rarely, it can appear as an extensive pigmented plate, which may be clinically indistinguishable from superficial spreading melanoma and Bowen disease. Dermatoscopy has a high sensitivity in the diagnosis of basal cell carcinoma. When Menzies criteria are used; however, the final diagnosis is made by histopathology...
December 20, 2016: Medwave
https://www.readbyqxmd.com/read/28067922/-reconstructieve-facial-surgery-in-facial-defects-after-the-surgical-removal-of-malignant-skin-tumours
#20
S Bolouri, F Bierenbroodspot, J Jansma
Because of the enormous and continuing increase in cases of skin cancer in the Netherlands, dentists will increasingly see patients with skin cancer. The most common malignant skin cancers are basal cell carcinoma, squamous cell carcinoma and malignant melanoma. With resection of a skin tumour, the oncological principles should be applied. For the closure of the resulting defect, a choice for the individual patient is made out of numerous techniques. Facial reconstructive surgery aims to restore the face in form and function and to maintain the patient's quality of life...
January 2017: Nederlands Tijdschrift Voor Tandheelkunde
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