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https://www.readbyqxmd.com/read/28722163/risk-of-cancer-in-patients-with-psoriasis-on-biologic-therapies-a-systematic-review
#1
REVIEW
E Peleva, L S Exton, K Kelley, K J Mason, C H Smith
Biologic therapies are highly effective in psoriasis, but have profound effects on innate and adaptive immune pathways that may negatively impact on cancer immunosurveillance mechanisms. To investigate the risk of cancer in psoriasis patients treated with biologic therapy we searched Medline, Embase, and the Cochrane Library (up to August 2016) for randomized control trials, prospective cohort studies and systematic reviews that reported cancer incidence in people exposed to biologic therapy for psoriasis compared to a control population...
July 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28718799/zebrafish-as-a-model-organism-for-the-development-of-drugs-for-skin-cancer
#2
REVIEW
Fatemeh Bootorabi, Hamed Manouchehri, Reza Changizi, Harlan Barker, Elisabetta Palazzo, Annalisa Saltari, Mataleena Parikka, Carlo Pincelli, Ashok Aspatwar
Skin cancer, which includes melanoma and squamous cell carcinoma, represents the most common type of cutaneous malignancy worldwide, and its incidence is expected to rise in the near future. This condition derives from acquired genetic dysregulation of signaling pathways involved in the proliferation and apoptosis of skin cells. The development of animal models has allowed a better understanding of these pathomechanisms, with the possibility of carrying out toxicological screening and drug development. In particular, the zebrafish (Danio rerio) has been established as one of the most important model organisms for cancer research...
July 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28716738/photodynamic-therapy-and-pain-a-systematic-review
#3
Jennifer Maria Ang, Irbaz Bin Riaz, Muhammad Umar Kamal, Gyorgy Paragh, Nathalie C Zeitouni
Photodynamic therapy (PDT) is an effective treatment for actinic keratoses and early skin cancers, and the only office procedure to control field cancerization. Procedure-associated pain limits widespread PDT use and by early termination of treatment can decrease overall therapeutic efficacy. Here we review and assess reported interventions on PDT-associated pain, in order to identify the most promising methods to manage treatment-associated pain and identify focus for future studies. Literature search was performed using MEDLINE, EMBASE, and the Cochrane Library by two independent reviewers to select publications that assessed and compared pain quantitatively during PDT treatment for actinic keratoses, basal cell carcinomas, and/or in situ squamous cell carcinomas...
July 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28713981/neuroendocrine-factors-the-missing-link-in-non%C3%A2-melanoma-skin-cancer-review
#4
Mihai Lupu, Ana Caruntu, Constantin Caruntu, Laura Maria Lucia Papagheorghe, Mihaela Adriana Ilie, Vlad Voiculescu, Daniel Boda, Constantin Carolina, Cristiana Tanase, Maria Sifaki, Nikolaos Drakoulis, Charalampos Mamoulakis, George Tzanakakis, Monica Neagu, Demetrios A Spandidos, Boris N Izotov, Aristides M Tsatsakis
Non‑melanoma skin cancer (NMSC) is the most common form of cancer worldwide, comprising 95% of all cutaneous malignancies and approximately 40% of all cancers. In spite of intensive efforts aimed towards awareness campaigns and sun‑protective measures, epidemiological data indicate an increase in the incidence of NMSC. This category of skin cancers has many common environmental triggers. Arising primarily on sun‑exposed skin, it has been shown that ultraviolet radiation is, in the majority of cases, the main trigger involved in the pathogenesis of NMSC...
July 13, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28711897/studying-risk-factors-for-skin-cancer-development
#5
Оlena О Оshyvalova
INTRODUCTION: In most countries with a population of mainly European origin, non-melanoma skin carcinoma incidence rate has increased over the last decade. Understanding of what is the best way to identify people at high risk for skin cancer development will help to optimize the strategy for prevention and treatment tactics. Aim of the research involves studying risk factors for skin cancer development in patients with cutaneous squamous cell carcinoma and squamous cell carcinoma in situ (cSCC and SCCis correspondingly) and patients with actinic keratosis (AK)...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28708084/molecular-mechanisms-of-human-papillomavirus-induced-skin-carcinogenesis
#6
Martin Hufbauer, Baki Akgül
Infection of the cutaneous skin with human papillomaviruses (HPV) of genus betapapillomavirus (βHPV) is associated with the development of premalignant actinic keratoses and squamous cell carcinoma. Due to the higher viral loads of βHPVs in actinic keratoses than in cancerous lesions, it is currently discussed that these viruses play a carcinogenic role in cancer initiation. In vitro assays performed to characterize the cell transforming activities of high-risk HPV types of genus alphapapillomavirus have markedly contributed to the present knowledge on their oncogenic functions...
July 14, 2017: Viruses
https://www.readbyqxmd.com/read/28707459/nationwide-trends-in-the-incidence-of-melanoma-and-non-melanoma-skin-cancers-from-1999-to-2014-in-south-korea
#7
Chang-Mo Oh, Hyunsoon Cho, Young-Joo Won, Hyun-Joo Kong, Yun Ho Roh, Ki-Heon Jeong, Kyu-Won Jung
Purpose: This descriptive study was aimed to examine trends in the incidence of melanoma and non-melanoma in South Korea. Materials and Methods: The nationwide incidence data for melanoma and non-melanoma skin cancer was obtained from the Korea Central Cancer Registry. Age-standardized rates were calculated and analyzed, using a joinpoint regression model. Results: The incidence of basal cell carcinoma has increased dramatically both in men (average annual percentage change [AAPC]: 8...
July 14, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28703911/low-incidence-of-metastasis-and-recurrence-from-cutaneous-squamous-cell-carcinoma-found-in-a-uk-population-do-we-need-to-adjust-our-thinking-on-this-rare-but-potentially-fatal-event
#8
Toby G Nelson, Richard E Ashton
BACKGROUND AND METHODS: Cutaneous squamous cell carcinoma (cSCC) is the commonest skin cancer with metastatic potential, however, reported rates of metastasis varies greatly. All cases of primary cSCC on the Isle of Wight between 2005 and 2014 were identified and retrospectively followed for recurrence and/or metastasis. Primary outcome was to identify the rate of metastasis/recurrence from cSCC. Secondary outcomes included associated risk factors for metastasis/recurrence, death from cSCC, and time from diagnosis of primary cSCC to event...
July 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28701207/development-of-a-core-outcome-set-for-clinical-trials-in-squamous-cell-carcinoma-study-protocol-for-a-systematic-review-of-the-literature-and-identification-of-a-core-outcome-set-using-a-delphi-survey
#9
Daniel I Schlessinger, Sanjana Iyengar, Arianna F Yanes, Sarah G Chiren, Victoria Godinez-Puig, Brian R Chen, Anastasia O Kurta, Jochen Schmitt, Stefanie Deckert, Karina C Furlan, Emily Poon, Todd V Cartee, Ian A Maher, Murad Alam, Joseph F Sobanko
BACKGROUND: Squamous cell carcinoma (SCC) is a common skin cancer that poses a risk of metastasis. Clinical investigations into SCC treatment are common, but the outcomes reported are highly variable, omitted, or clinically irrelevant. The outcome heterogeneity and reporting bias of these studies leave clinicians unable to accurately compare studies. Core outcome sets (COSs) are an agreed minimum set of outcomes recommended to be measured and reported in all clinical trials of a given condition or disease...
July 12, 2017: Trials
https://www.readbyqxmd.com/read/28700773/association-of-multiple-primary-skin-cancers-with-human-immunodeficiency-virus-infection-cd4-count-and-viral-load
#10
Maryam M Asgari, G Thomas Ray, Charles P Quesenberry, Kenneth A Katz, Michael J Silverberg
Importance: Persons with human immunodeficiency virus (HIV) have a 2.8-fold higher risk than HIV-uninfected persons of nonmelanoma skin cancer (NMSC), defined as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Individuals with a prior NMSC history are at increased risk for subsequent NMSC, but the magnitude of risk and its relation to HIV disease-related factors, including CD4 count and viral load (VL), are unknown. Objective: To better understand how laboratory markers currently used to evaluate HIV disease progression may be associated with subsequent NMSC risk...
July 12, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28692322/the-use-of-lasers-in-the-treatment-of-skin-cancer-a-review
#11
Fatima N Mirza, Khalil A Khatri
BACKGROUND: In considering skin cancer, a number of factors - including effectiveness, simplicity of treatment, cost, and aesthetic outcomes - are important to ensure patient satisfaction. There are several existing interventions, such as electrodessication and curettage, excision, Mohs surgery, radiation therapy, cryotherapy, and topical/oral treatments. Laser therapy has emerged as a new promising alternative that should be explored. OBJECTIVE: To review the dermatologic literature on the use of laser therapy in the treatment of skin cancer...
July 10, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28692192/aromatic-hydrocarbons-and-risk-of-skin-cancer-by-anatomical-site-in-25%C3%A2-000-male-offshore-petroleum-workers
#12
Jo Steinson Stenehjem, Trude Eid Robsahm, Magne Bråtveit, Sven Ove Samuelsen, Jorunn Kirkeleit, Tom Kristian Grimsrud
BACKGROUND: We prospectively examined skin cancer risk according to occupational exposure to aromatic hydrocarbons with adjustment for ultraviolet radiation exposure, in a cohort of 24 917 male offshore petroleum workers. METHODS: Hazard ratios (HRs) and 95% confidence intervals were estimated with Cox regression adapted to a stratified case-cohort design. RESULTS: During 13.5 years of follow-up, 112 cutaneous melanomas (CMs) and 70 non-melanoma skin cancers were identified...
August 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28692051/transcriptional-regulation-of-ataxia-telangiectasia-and-rad3-related-protein-by-activated-p21-activated-kinase-1-protects-keratinocytes-in-uv-b-induced-premalignant-skin-lesions
#13
S Beesetti, J Mavuluri, R P Surabhi, T M Oberyszyn, K Tober, R S Pitani, L D Joseph, G Venkatraman, S K Rayala
Sun-induced skin lesions, in particular actinic keratosis, are generally considered as premalignant skin lesions that can progress into squamous cell carcinoma (SCC) and invasive SCC if left untreated. Therefore, understanding the molecular mechanisms by which the ultraviolet-B (UV-B)-exposed cells are being protected and the signaling pathways that promote the progression of certain premalignant skin lesions to malignant lesions will permit us to prevent or cure skin cancers. In the current study, we found that phospho-p21-activated kinase-1 (Pak1) and Pak1 expression was high in clinical samples of sunlight-induced premalignant skin lesions assessed by immunohistochemistry...
July 10, 2017: Oncogene
https://www.readbyqxmd.com/read/28684431/convergent-roles-of-atf3-and-csl-in-chromatin-control-of-cancer-associated-fibroblast-activation
#14
Dong Eun Kim, Maria-Giuseppina Procopio, Soumitra Ghosh, Seung-Hee Jo, Sandro Goruppi, Francesco Magliozzi, Pino Bordignon, Victor Neel, Paolo Angelino, G Paolo Dotto
Cancer-associated fibroblasts (CAFs) are important for tumor initiation and promotion. CSL, a transcriptional repressor and Notch mediator, suppresses CAF activation. Like CSL, ATF3, a stress-responsive transcriptional repressor, is down-modulated in skin cancer stromal cells, and Atf3 knockout mice develop aggressive chemically induced skin tumors with enhanced CAF activation. Even at low basal levels, ATF3 converges with CSL in global chromatin control, binding to few genomic sites at a large distance from target genes...
July 6, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28679298/prevalence-of-cutaneous-viral-infections-in-incident-cutaneous-squamous-cell-carcinoma-detected-among-chronic-lymphocytic-leukemia-and-hematopoietic-stem-cell-transplant-patients
#15
Shalaka S Hampras, Frederick L Locke, Julio C Chavez, Nishit S Patel, Anna R Giuliano, Kyle Miller, Tarik Gheit, Massimo Tommasino, Dana E Rollison
The role of cutaneous viral infections in the development of non-melanoma skin cancer (NMSC), including cutaneous squamous cell carcinoma (SCC), among chronic lymphocytic leukemia (CLL) and blood and marrow transplant (BMT) patients is not established. CLL (n = 977) and BMT (n = 3587) patients treated at the Moffitt Cancer Center were included in a retrospective cohort study. Human papillomavirus (HPV) and human polyomavirus (HPyV) DNA were examined in a subset of incident SCC tumors. Five-year cumulative incidence of NMSC was 1...
July 6, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28676883/dermoscopy-confocal-microscopy-and-other-non-invasive-tools-for-the-diagnosis-of-non-melanoma-skin-cancers-and-other-skin-conditions
#16
Josep Malvehy, Giovanni Pellacani
Non-melanoma skin cancer (NMSC), including basal cell and squamous cell carcinomas, is the most common form of neoplasm. The incidence of NMSC is increasing worldwide. The cure rate is high with early detection and appropriate treatment. Visual examination is the first screening tool used by clinicians, but it is sometimes not sufficient to discriminate benign from malignant lesions. Skin biopsy with histopathology is the gold standard for differential diagnosis; however, this procedure is invasive and occasionally painful...
July 5, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28676162/skin-and-composite-grafting-techniques-in-facial-reconstruction-for-skin-cancer
#17
REVIEW
Michael J Brenner, Jeffrey S Moyer
Skin and composite grafting provide effective resurfacing and reconstruction for cutaneous defects after excision of the malignancy. The goal is to restore a natural appearance and function while preventing distortion of the eyelid, nose, or lips. With careful planning and attention to aesthetic subunits, the surgeon can camouflage incisions and avoid blunting aesthetically sensitive sulci. The surgical plan is also informed by the pathology, as basal or squamous cell carcinomas removed by Mohs micrographic excision have different prognostic and logistical considerations from melanoma...
August 2017: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/28676156/anatomy-of-the-skin-and-the-pathogenesis-of-nonmelanoma-skin-cancer
#18
REVIEW
William D Losquadro
Skin is composed of the epidermis, dermis, and adnexal structures. The epidermis is composed of 4 layers-the stratums basale, spinosum, granulosum, and corneum. The dermis is divided into a superficial papillary dermis and deeper reticular dermis. Collagen and elastin within the reticular dermis are responsible for skin tensile strength and elasticity, respectively. The 2 most common kinds of nonmelanoma skin cancers are basal cell and squamous cell carcinoma. Both are caused by a host of environmental and genetic factors, although UV light exposure is the single greatest predisposing factor...
August 2017: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/28676072/giant-desmoplastic-cutaneous-squamous-cell-carcinoma-of-the-gluteal-region
#19
Darko Katalinic, Antonio Juretic
Cutaneous squamous cell carcinoma (cSCC) is the most common type of skin tumour with the ability of metastatic spread. It represents about 20% of all malignancies diagnosed worldwide each year. Despite increased knowledge regarding the causes of skin cancer, the incidence of cSCC rises. The disease originates from epidermal keratinocytes, but it may occur on all areas of the body. It has an invasive nature and the potential to metastasise. We report unusual case of a giant metastatic desmoplastic cSCC of the gluteal region in a patient with previously resected desmoplastic cSCC presenting 8 months later with multiple liver and lung metastases...
July 4, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28672959/antimicrobial-peptide-ll-37-promotes-the-viability-and-invasion-of-skin-squamous-cell-carcinoma-by-upregulating-yb-1
#20
Wei Wang, Yan Zheng, Jinjing Jia, Changji Li, Qiqi Duan, Ruilian Li, Xin Wang, Yongping Shao, Caifeng Chen, Huling Yan
Antimicrobial peptide LL-37 serves a function in the host defense against microbial invasion, and also regulates cell proliferation, immune activity and angiogenesis. Previous studies have reported that LL-37 participates in the development of numerous tumour types, such as ovarian cancer, lung cancer, melanoma and breast cancer. However, the function of LL-37 in the development of skin squamous cell carcinoma (SCC) has not yet been fully elucidated. The aim of the current study was to investigate how LL-37 promotes the expression of Y-box binding protein 1 (YB-1) in SCC...
July 2017: Experimental and Therapeutic Medicine
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