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https://www.readbyqxmd.com/read/29684955/-a-case-of-sarcomatoid-squamous-cell-carcinoma-of-the-penis
#1
Atsushi Wanifuchi, Takashi Shimizu, Hiroshi Hotta
A 74-year-old man presented to our hospital with the swelling of penis in May 2016. Physical examination revealed a goose egg-sized lump at the tip of the penis under foreskin. After dorsal skin incision we confirmed the 7 cm tumor on the inner preputial skin and then resected the tumor with circumcision. Histopathological examination revealed sarcomatoid squamous cell carcinoma of the penis. Computed tomography (CT) revealed swelling of bilateral inguinal lymph nodes, and we performed partial penectomy with bilateral superficial inguinal lymph node dissection in July 2016...
February 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29680587/azathioprine-to-mycophenolate-mofetil-transition-and-risk-of-squamous-cell-carcinoma-after-lung-transplantation
#2
Martin Vos, Elsemieke I Plasmeijer, Barbara C van Bemmel, Wim van der Bij, Nina S Klaver, Michiel E Erasmus, Geertruida H de Bock, Erik A M Verschuuren, Emőke Rácz
BACKGROUND: Chronic immunosuppression after solid-organ transplantation is a risk factor for cutaneous squamous cell carcinoma (cSCC) development. Certain immunosuppressant drugs, namely azathioprine and calcineurin inhibitors, increase this risk more than others. We investigated incidence of cSCC in a Dutch lung transplant recipient (LTR) cohort and analyzed associated risk factors. METHODS: All LTRs with post-transplant survival of >30 days were included. Data included indication for lung transplantation and duration of medication use...
March 19, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29662191/wnt-ligands-control-initiation-and-progression-of-human-papillomavirus-driven-squamous-cell-carcinoma
#3
Dario Zimmerli, Virginia Cecconi, Tomas Valenta, George Hausmann, Claudio Cantù, Gaetana Restivo, Jürg Hafner, Konrad Basler, Maries van den Broek
Human papillomavirus (HPV)-driven cutaneous squamous cell carcinoma (cSCC) is the most common cancer in immunosuppressed patients. Despite indications suggesting that HPV promotes genomic instability during cSCC development, the molecular pathways underpinning HPV-driven cSCC development remain unknown. We compared the transcriptome of HPV-driven mouse cSCC with normal skin and observed higher amounts of transcripts for Porcupine and WNT ligands in cSCC, suggesting a role for WNT signaling in cSCC progression...
April 17, 2018: Oncogene
https://www.readbyqxmd.com/read/29661336/cutaneous-head-and-neck-malignancies-in-the-elderly
#4
REVIEW
Brian B Hughley, Cecelia E Schmalbach
Cutaneous malignancy of the head and neck affects a large proportion of elderly patients. The severity ranges from small, easily treatable lesions to large, invasive, potentially metastatic tumors. Surgical treatment is the primary treatment of most skin cancers; however, geriatric patients are more likely to have multiple comorbidities that increase the risk of surgery. Multiple treatment modalities exist, including surgical, radiation, and medical therapy. Recommendations and treatment options for basal cell carcinoma, squamous cell carcinoma, Merkel cell carcinoma, and melanoma are outlined and reviewed...
May 2018: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/29648676/sentinel-lymph-node-biopsy-in-cutaneous-squamous-cell-carcinoma-series-of-37-cases-and-systematic-review-of-the-literature
#5
Raphael Lhote, Jérôme Lambert, Jumie Lejeune, Jeremy Gottlieb, Antoine Badaoui, Maxime Battistella, Jennifer Roux, Cecile Pages, Laetitia Vercellino, Catherine Vilmer, Christine Le Maignan, Catherine Escande, Besma MBarek, Martine Bagot, Celeste Lebbé, Nicole Basset-Seguin
Cutaneous squamous cell carcinoma is one of the most common skin cancers and can lead to patient death. Early diagnosis of node metastasis is a major goal for dermatologists and oncologists. The sentinel lymph node procedure has been proposed to improve this issue but is still debated. To evaluate the efficacy and the impact of this technique on prognosis of cutaneous squamous cell carcinoma, 37 patients (Saint Louis Hospital, Paris - France) who underwent sentinel lymph node biopsy and 290 cases from the literature were analyzed...
April 12, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29619990/do-cancer-registries-play-a-role-in-determining-the-incidence-of-non-melanoma-skin-cancers
#6
Carlos Anselmo Lima, Marcela Sampaio Lima, Angela Maria Da Silva, Marco Antonio Prado Nunes, Marcia Maria Macedo Lima, Marceli Oliveira Santos, Divaldo Lyra, Carlos Kleber Alves
Non-melanoma skin cancers have the highest incidence of all malignancies worldwide. However, cancer registries rarely include data on non-melanoma skin cancers because they tend to be under-reported. To determine incidence rates and changes over time for non-melanoma skin cancers in a mid-sized Brazilian population. We calculated age-standardized rates, adjusted to the world population using the direct method, from 1996-2012 in the Aracaju Cancer Registry and then calculated incidence trends using the Joinpoint Regression Program...
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29619343/alterations-of-the-human-skin-n-and-o-glycome-in-basal-cell-carcinoma-and-squamous-cell-carcinoma
#7
Uwe Möginger, Sonja Grunewald, René Hennig, Chu-Wei Kuo, Falko Schirmeister, Harald Voth, Erdmann Rapp, Kay-Hooi Khoo, Peter H Seeberger, Jan C Simon, Daniel Kolarich
The glycome of one of the largest and most exposed human organs, the skin, as well as glycan changes associated with non-melanoma skin cancers have not been studied in detail to date. Skin cancers such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are among the most frequent types of cancers with rising incidence rates in the aging population. We investigated the healthy human skin N - and O -glycome and its changes associated with BCC and SCC. Matched patient samples were obtained from frozen biopsy and formalin-fixed paraffin-embedded tissue samples for glycomics analyses using two complementary glycomics approaches: porous graphitized carbon nano-liquid chromatography electro spray ionization tandem mass spectrometry and capillary gel electrophoresis with laser induced fluorescence detection...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29603761/an-experimental-investigation-of-a-novel-iron-chelating-protoporphyrin-ix-prodrug-for-the-enhancement-of-photodynamic-therapy
#8
Lizette Anayo, Anette Magnussen, Alexis Perry, Mark Wood, Alison Curnow
OBJECTIVES: Non-melanoma skin cancers are the most frequently occurring type of cancer worldwide. They can be effectively treated using topical dermatological photodynamic therapy (PDT) employing protoporphyrin IX (PpIX) as the active photosensitising agent as long as the disease remains superficial. Novel iron chelating agents are being investigated to enhance the effectiveness and extend the applications of this treatment modality, as limiting free iron increases the accumulation of PpIX available for light activation and thus cell kill...
March 31, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29594354/detection-of-the-merkel-cell-polyomavirus-in-the-neuroendocrine-component-of-combined-merkel-cell-carcinoma
#9
Thibault Kervarrec, Mahtab Samimi, Pauline Gaboriaud, Tarik Gheit, Agnès Beby-Defaux, Roland Houben, David Schrama, Gaëlle Fromont, Massimo Tommasino, Yannick Le Corre, Eva Hainaut-Wierzbicka, Francois Aubin, Guido Bens, Hervé Maillard, Adeline Furudoï, Patrick Michenet, Antoine Touzé, Serge Guyétant
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin. The main etiological agent is Merkel cell polyomavirus (MCPyV), detected in 80% of cases. About 5% of cases, called combined MCC, feature an admixture of neuroendocrine and non-neuroendocrine tumor cells. Reports of the presence or absence of MCPyV in combined MCC are conflicting, most favoring the absence, which suggests that combined MCC might have independent etiological factors and pathogenesis. These discrepancies might occur with the use of different virus identification assays, with different sensitivities...
March 28, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29593028/5-fluorouracil-enhances-protoporphyrin-ix-accumulation-and-lesion-clearance-during-photodynamic-therapy-of-actinic-keratoses-a-mechanism-based-clinical-trial
#10
Edward V Maytin, Sanjay Anand, Margo Riha, Sara Lohser, Alejandra Tellez, Rim Ishak, Lauren Karpinski, Janine Sot, Bo Hu, Anton Denisyuk, Scott C Davis, Angela Kyei, Allison Vidimos
PURPOSE: Actinic keratoses (AK) are precancerous lesions that can progress to squamous cell carcinoma. Photodynamic therapy (PDT) and topical 5-fluorouracil (5FU) are commonly used for AK. Empirical reports suggest that combining them can improve the therapeutic response. However, the optimal combined regimen was not clear in terms of proper sequence, timing, and mechanism. This clinical study explored mechanisms of action for neoadjuvantal 5FU and PDT for treatment of AK. EXPERIMENTAL DESIGN: A bilaterally controlled trial (17 patients) was performed...
March 28, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29588249/risk-of-skin-cancer-in-hiv-infected-patients-a-danish-nationwide-cohort-study
#11
Silje Haukali Omland, Magnus Glinvad Ahlström, Jan Gerstoft, Gitte Pedersen, Rajesh Mohey, Court Pedersen, Gitte Kronborg, Carsten Schade Larsen, Birgit Kvinesdal, Robert Gniadecki, Niels Obel, Lars Haukali Omland
BACKGROUND: The risk of skin cancer in HIV-infected patients has not been extensively studied. OBJECTIVE: To determine the risk of skin cancer in HIV-infected patients and compare it with the risk in the background population. METHODS: In a matched, nationwide population-based cohort study we compared the risk of skin cancer in 4280 HIV-infected patients from the Danish HIV cohort study with a background population cohort, according to the level of immunosuppression and route of transmission...
March 24, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29582369/field-cancerization-therapies-for-management-of-actinic-keratosis-a-narrative-review
#12
REVIEW
Nathan Jetter, Neha Chandan, Stephanie Wang, Maria Tsoukas
Actinic keratoses (AKs) are atypical, precancerous proliferations of keratinocytes that develop because of chronic exposure to ultraviolet (UV) radiation. Treatment of AK can be lesion-directed or field-directed. Field cancerization theory postulates that the skin surrounding AK is also at increased risk for possible malignant transformation since it has been exposed to the same chronic UV light. Field-directed therapies thus have the potential to address subclinical damage, reduce AK recurrence rates, and potentially reduce the risk of squamous cell carcinoma (SCC) development...
March 26, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29575799/sentinel-lymph-node-biopsy-in-33-non-melanoma-skin-cancers-of-the-head-and-neck-a-twelve-year-experience-with-long-term-follow-up
#13
J P Foy, F Kolb, E Routier, A Cavalcanti, J Lumbroso, G Tomasic, C Mateus, S Temam, C Robert, A Moya-Plana
Non-melanoma skin cancer (NMSC), the most common malignancy worldwide, includes Merkel cell carcinoma (MCC) and cutaneous squamous cell carcinoma (CSCC). Although CSCC are often associated with favorable outcomes, one to ten percent of cases develop regional metastatic disease, lowering significantly the survival rate. In contrast, MCC is aggressive with high rate of loco-regional disease (around 50%), resulting in a poor prognosis. This article is protected by copyright. All rights reserved.
March 24, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29573497/inverse-association-for-diagnosis-of-alzheimer-s-disease-subsequent-to-both-melanoma-and-non-melanoma-skin-cancers-in-a-large-urban-single-center-midwestern-u-s-patient-population
#14
Erin Ibler, Gary Tran, Kelsey A Orrell, Linda Serrano, Sara Majewski, Kimberly A Sable, Rebecca Thiede, Anne E Laumann, Dennis P West, Beatrice Nardone
BACKGROUND: Although literature demonstrates a decreased risk of Alzheimer's disease (AD) in individuals with various cancers, including squamous cell cancers (SCC) and basal cell cancers (BCC) comprising non-melanoma skin cancers (NMSC), there is a paucity of literature to substantiate an association between malignant melanoma (MM) and AD. OBJECTIVE: The aim of this study is to determine if an association exists between MM and AD as well as for NMSC and AD. METHODS: A large urban, Midwestern, U...
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29572176/perineural-spread-of-non-melanoma-skin-cancer-to-the-brachial-plexus-identifying-an-anatomical-pathway-s
#15
Tomas Marek, B Matthew Howe, Kimberly K Amrami, Robert J Spinner
BACKGROUND: Perineural spread leading to brachial plexopathy has recently been described in cases of melanoma. The occurrence and mechanism for non-melanoma skin cancer spread to the brachial plexus is poorly understood. MATERIALS AND METHODS: A retrospective chart review of Mayo Clinic database was conducted to identify patients with non-melanoma skin cancer and brachial plexopathy between 2000 and 2017. Inclusion criteria were a history of non-melanoma skin cancer, a clinical diagnosis of brachial plexopathy, imaging features of perineural spread, and a positive biopsy showing tumor in a skin nerve...
March 20, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29570823/a-pediatric-case-of-squamous-cell-cancer-in-situ-in-the-setting-of-sclerodermatous-graft-versus-host-disease-and-voriconazole-treatment
#16
Alvin W Li, Leah E Lalor, Fernanda Bellodi Schmidt, Minnelly Luu
Sclerodermatous graft-versus-host disease is a subtype of cutaneous chronic graft-versus-host disease that is characterized by sclerosis of the skin and subcutaneous tissue, resulting in debilitating contractures, among other life-threatening complications. Children with sclerodermatous graft-versus-host disease are at high risk of developing nonmelanoma skin cancer because of several risk factors, including young age at transplantation, prolonged immunosuppression, and exposure to photosensitizing antimicrobial prophylaxis such as voriconazole...
March 23, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29569417/dermoscopy-features-of-atypical-fibroxanthoma-a-multicenter-study-of-the-international-dermoscopy-society
#17
Elvira Moscarella, Simonetta Piana, Francesca Specchio, Athanassios Kyrgidis, Gianluca Nazzaro, Maite L Eliceche, Francesco Savoia, Leonardo Bugatti, Giorgio Filosa, Iris Zalaudek, Federica Scarfi, Mike Inskip, Cliff Rosendahl, John H Pyne, Graeme Siggs, Arzu K Toğral, Horatio Cabo, Lubomir Drlik, Aimilios Lallas, Caterina Longo, Giuseppe Argenziano
BACKGROUND/OBJECTIVES: Little is known about the dermoscopic features of atypical fibroxanthoma. METHODS: This was a case-control study. Atypical fibroxanthoma lesions were compared with a control group with non-melanoma skin cancer. RESULTS: Altogether 40 atypical fibroxanthoma were collected. Most developed in men (93%), appearing mainly as nodular (63%), amelanotic (93%) and ulcerated (78%) lesions. Most lesions were located on the scalp (55%) and the ears (13%)...
March 23, 2018: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/29568286/inhibition-of-tgf-%C3%AE-and-notch-signaling-by-cutaneous-papillomaviruses
#18
REVIEW
Jordan M Meyers, Miranda Grace, Aayushi Uberoi, Paul F Lambert, Karl Munger
Infections with cutaneous papillomaviruses have been linked to cutaneous squamous cell carcinomas that arise in patients who suffer from a rare genetic disorder, epidermodysplasia verruciformis, or those who have experienced long-term, systemic immunosuppression following organ transplantation. The E6 proteins of the prototypical cutaneous human papillomavirus (HPV) 5 and HPV8 inhibit TGF-β and NOTCH signaling. The Mus musculus papillomavirus 1, MmuPV1, infects laboratory mouse strains and causes cutaneous skin warts that can progress to squamous cell carcinomas...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29566921/epidemiology-of-skin-cancer-in-the-mature-patient
#19
Vivien Lai, William Cranwell, Rodney Sinclair
Epidermal cancers include keratinocyte cancer, melanocyte cancer, and Merkel cell carcinoma. These cancers account for the vast majority of new cancers diagnosed in Australia, North America, and Europe. Keratinocyte cancer is the most common epidermal cancer and accounts for 7 out of 8 new cancers diagnosed in Australia. Melanoma and Merkel cell carcinoma are less common than keratinocyte carcinoma but are more important causes of mortality in Australia. Keratinocyte cancer has also been demonstrated to be a marker of cancer-prone phenotype...
March 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29566384/parkinson-s-disease-melanoma-and-keratinocyte-carcinoma-a-population-based-study
#20
Sharon Lerman, Boaz Amichai, Gabriel Weinstein, Varda Shalev, Gabriel Chodick
BACKGROUND: The association between Parkinson's disease (PD) and melanoma is well recognized, but its relationship with non-melanoma skin cancers has not been studied in depth. OBJECTIVE: To assess the relationship between PD, and risk of melanoma and keratinocyte carcinoma: squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). METHODS: This historical cohort study used the data of 1.2 million adult members of a large health organization between 2000 and 2015...
March 22, 2018: Neuroepidemiology
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