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https://www.readbyqxmd.com/read/27913619/the-caenorhabditis-elegans-nf2-merlin-molecule-nfm-1-non-autonomously-regulates-neuroblast-migration-and-interacts-genetically-with-the-guidance-cue-slt-1-slit
#1
Matthew P Josephson, Rana Aliani, Megan L Norris, Matthew E Ochs, Mahekta Gujar, Erik A Lundquist
During nervous system development, neurons and their progenitors migrate to their final destinations. In Caenorhabditis elegans, the bilateral Q neuroblasts and their descendants migrate long distances in opposite directions, despite being born in the same posterior region. QR on the right migrates anteriorly and generates the AQR neuron positioned near the head, and QL on the left migrates posteriorly, giving rise to the PQR neuron positioned near the tail. In a screen for genes required for AQR and PQR migration, we identified an allele of nfm-1, which encodes a molecule similar to vertebrate NF2/Merlin, an important tumor suppressor in humans...
December 2, 2016: Genetics
https://www.readbyqxmd.com/read/27502132/-clinical-experience-of-2-543-cases-of-congenital-heart-diseases-undergoing-totally-thoracoscopic-cardiac-surgery-in-a-single-center
#2
X Z Xu, W Yi, H Li, G Y Shi, Y W Chen, N Qiao, M Chen, Z X Jin, R Zhao, Y Jin, S Q Yu
OBJECTIVE: To summarize the experience of totally thoracoscopic cardiac surgical (TTCS) at congenital heart diseases (CHD) treatment. METHODS: From April 2000 to March 2016, 2 543 patients with CHD underwent TTCS in Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, including 957 male and 1 586 female patients. The age ranged from 0.5 to 66.0 years with a mean age of (21±18) years. The body weight ranged from 6 to 118 kg with a mean of (49±30) kg...
August 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27471551/virus-like-attachment-sites-as-structural-landmarks-of-plants-retrotransposons
#3
Edgar Andres Ochoa Cruz, Guilherme Marcello Queiroga Cruz, Andréia Prata Vieira, Marie-Anne Van Sluys
BACKGROUND: The genomic data available nowadays has enabled the study of repetitive sequences and their relationship to viruses. Among them, long terminal repeat retrotransposons (LTR-RTs) are the largest component of most plant genomes, the Gypsy and Copia superfamilies being the most common. Recently it has been found that Del lineage, an LTR-RT of Gypsy superfamily, has putative virus-like attachment (vl-att) sites. This signature, originally described for retroviruses, is recognized by retroviral integrase conferring specificity to the integration process...
2016: Mobile DNA
https://www.readbyqxmd.com/read/27225683/nonautonomous-roles-of-mab-5-hox-and-the-secreted-basement-membrane-molecule-spon-1-f-spondin-in-caenorhabditis-elegans-neuronal-migration
#4
Matthew P Josephson, Adam M Miltner, Erik A Lundquist
Nervous system development and circuit formation requires neurons to migrate from their birthplaces to specific destinations.Migrating neurons detect extracellular cues that provide guidance information. In Caenorhabditis elegans, the Q right (QR) and Q left (QL) neuroblast descendants migrate long distances in opposite directions. The Hox gene lin-39 cell autonomously promotes anterior QR descendant migration, and mab-5/Hox cell autonomously promotes posterior QL descendant migration. Here we describe a nonautonomous role of mab-5 in regulating both QR and QL descendant migrations, a role masked by redundancy with lin-39 A third Hox gene, egl-5/Abdominal-B, also likely nonautonomously regulates Q descendant migrations...
August 2016: Genetics
https://www.readbyqxmd.com/read/27129312/implementation-of-online-veterinary-hospital-on-cloud-platform
#5
Tzer-Shyong Chen, Tzer-Long Chen, Yu-Fang Chung, Yao-Min Huang, Tao-Chieh Chen, Huihui Wang, Wei Wei
Pet markets involve in great commercial possibilities, which boost thriving development of veterinary hospital businesses. The service tends to intensive competition and diversified channel environment. Information technology is integrated for developing the veterinary hospital cloud service platform. The platform contains not only pet medical services but veterinary hospital management and services. In the study, QR Code andcloud technology are applied to establish the veterinary hospital cloud service platform for pet search by labeling a pet's identification with QR Code...
June 2016: Journal of Medical Systems
https://www.readbyqxmd.com/read/27049618/structural-and-evolutionary-relationships-among-rubiscos-inferred-from-their-large-and-small-subunits
#6
Fu Xiang, Yuanping Fang, Jun Xiang
Ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) is the key enzyme to assimilate CO(2) into the biosphere. The nonredundant structural data sets for three RuBisCO domain superfamilies, i.e. large subunit C-terminal domain (LSC), large subunit N-terminal domain (LSN) and small subunit domain (SS), were selected using QR factorization based on the structural alignment with QH as the similarity measure. The structural phylogenies were then constructed to investigate a possible functional significance of the evolutionary diversification...
2016: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/26876670/optimal-architectures-for-long-distance-quantum-communication
#7
Sreraman Muralidharan, Linshu Li, Jungsang Kim, Norbert Lütkenhaus, Mikhail D Lukin, Liang Jiang
Despite the tremendous progress of quantum cryptography, efficient quantum communication over long distances (≥ 1000 km) remains an outstanding challenge due to fiber attenuation and operation errors accumulated over the entire communication distance. Quantum repeaters (QRs), as a promising approach, can overcome both photon loss and operation errors, and hence significantly speedup the communication rate. Depending on the methods used to correct loss and operation errors, all the proposed QR schemes can be classified into three categories (generations)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26852275/molecular-cloning-snp-detection-and-association-analysis-of-5-flanking-region-of-the-goat-igf1-gene-with-prolificacy
#8
Naicy Thomas, Thirupathy Venkatachalapathy, Thazhathuveettil Aravindakshan, K C Raghavan
The insulin-like growth factor 1 has an important role in reproduction, foetal development and growth. It regulates the secretion of gonadotrophin releasing hormone, stimulates ovarian function and steroidogenesis. The present study was conducted to characterise the 5' flanking region of goat IGF 1 gene, ascertain ovarian expression of the IGF1 gene, detect SNPs and assess the association with prolificacy in the two indigenous goat breeds of South India viz., low prolific Attappady Black and high prolific Malabari...
April 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/26448025/clinical-features-of-acute-massive-pulmonary-embolism-complicated-by-radiofrequency-ablation-an-observational-study
#9
Yue-Chun Li, Jiafeng Lin, Lianpin Wu, Jia Li, Peng Chen, Xue-Qiang Guang
Although pulmonary embolism (PE) complicated by radiofrequency catheter ablation (RFCA) is rare, it can be life-threatening. Our goal was to elucidate the clinical features of acute massive PE after RFCA. Of 2386 patients who underwent RFCA for supraventricular tachycardia or idiopathic ventricular arrhythmia, 4 patients (0.16%) whose cases were complicated by acute massive PE were examined. These 4 patients were female and middle-aged (range 43-52 years), and 2 of the 4 patients had iron-deficiency anemia and reactive thrombocytosis...
October 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26334672/peg-phospholipids-coated-quantum-rods-as-amplifiers-of-the-photosensitization-process-by-fret
#10
Reut Timor, Hana Weitman, Nir Waiskopf, Uri Banin, Benjamin Ehrenberg
Singlet oxygen ((1)O2) generated upon photostimulation of photosensitizer molecules is a highly reactive specie which is utilized in photodynamic therapy. Recent studies have shown that semiconductor nanoparticles can be used as donors in fluorescence resonance energy transfer (FRET) process to excite attached photosensitizer molecules. In these studies, their unique properties, such as low nanoscale size, long-term photostability, wide broad absorbance band, large absorption cross section, and narrow and tunable emission bands were used to provide advantages over the traditional methods to produce singlet oxygen...
September 30, 2015: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26332757/efficacy-and-safety-of-bromocriptine-qr-in-type-2-diabetes-a-systematic-review-and-meta-analysis
#11
REVIEW
W Liang, L Gao, N Li, B Wang, L Wang, Y Wang, H Yang, L You, J Hou, S Chen, H Zhu, Y Jiang, H Pan
Bromocriptine-QR (quick release) is a novel treatment for type 2 diabetes. The objective of this study is to assess the efficacy and safety of bromocriptine-QR in adults with type 2 diabetes mellitus based on randomized controlled trials published in peer-reviewed journals or as abstracts. We performed a comprehensive literature search of MEDLINE, Pubmed, Web of Science, EMBASE, and the Cochrane Library up to May 2015. Randomized controlled trials of bromocriptine-QR therapy in type 2 diabetes mellitus were eligible...
October 2015: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/26060823/timed-bromocriptine-qr-therapy-reduces-progression-of-cardiovascular-disease-and-dysglycemia-in-subjects-with-well-controlled-type-2-diabetes-mellitus
#12
RANDOMIZED CONTROLLED TRIAL
Bindu Chamarthi, J Michael Gaziano, Lawrence Blonde, Aaron Vinik, Richard E Scranton, Michael Ezrokhi, Dean Rutty, Anthony H Cincotta
BACKGROUND: Type 2 diabetes (T2DM) patients, including those in good glycemic control, have an increased risk of cardiovascular disease (CVD). Maintaining good glycemic control may reduce long-term CVD risk. However, other risk factors such as elevated vascular sympathetic tone and/or endothelial dysfunction may be stronger potentiators of CVD. This study evaluated the impact of bromocriptine-QR, a sympatholytic dopamine D2 receptor agonist, on progression of metabolic disease and CVD in T2DM subjects in good glycemic control (HbA1c ≤ 7...
2015: Journal of Diabetes Research
https://www.readbyqxmd.com/read/26024232/cyclophanes-containing-large-polycyclic-aromatic-hydrocarbons
#13
Parisa Ghods Ghasemabadi, Tieguang Yao, Graham J Bodwell
Cyclophanes have been firmly entrenched as a distinct class of compounds for well over half a century. The two main factors that have kept this field of chemistry going so strongly for such a long time are tremendous structural diversity and the interesting behaviour that is often observed. Although a very large number cyclophanes has been reported, only a very small proportion of them contain polycyclic aromatic systems that can be thought of as "large", i.e. with ≥4 rings. This Review puts the spotlight on such cyclophanes, illuminating both the chemistry that was used to synthesize them and what was learned from studying them...
September 21, 2015: Chemical Society Reviews
https://www.readbyqxmd.com/read/26022087/neuroprotective-activities-of-curcumin-and-quercetin-with-potential-relevance-to-mitochondrial-dysfunction-induced-by-oxaliplatin
#14
Mohammad Waseem, Suhel Parvez
Peripheral neurotoxicity is one of the serious dose-limiting side effects of oxaliplatin (Oxa) when used in the treatment of malignant conditions. It is documented that it elicits major side effects specifically neurotoxicity due to oxidative stress forcing the patients to limit its clinical use in long-term treatment. Oxidative stress has been proven to be involved in Oxa-induced toxicity including neurotoxicity. The mitochondria have recently emerged as targets for anticancer drugs in various kinds of toxicity including neurotoxicity that can lead to neoplastic disease...
March 2016: Protoplasma
https://www.readbyqxmd.com/read/25705111/trends-of-voc-exposures-among-a-nationally-representative-sample-analysis-of-the-nhanes-1988-through-2004-data-sets
#15
Feng-Chiao Su, Bhramar Mukherjee, Stuart Batterman
Exposures to volatile organic compounds (VOCs) are ubiquitous due to emissions from personal, commercial and industrial products, but quantitative and representative information regarding long term exposure trends is lacking. This study characterizes trends from1988 to 2004 for the 15 VOCs measured in blood in five cohorts of the National Health and Nutrition Examination Survey (NHANES), a large and representative sample of U.S. adults. Trends were evaluated at various percentiles using linear quantile regression (QR) models, which were adjusted for solvent-related occupations and cotinine levels...
September 2011: Atmospheric Environment
https://www.readbyqxmd.com/read/25412625/a-multifunctional-peptide-based-on-the-neutrophil-immune-defense-molecule-cap37-has-antibacterial-and-wound-healing-properties
#16
Anne Kasus-Jacobi, Samaneh Noor-Mohammadi, Gina L Griffith, Heather Hinsley, Lauren Mathias, H Anne Pereira
CAP37, a protein constitutively expressed in human neutrophils and induced in response to infection in corneal epithelial cells, plays a significant role in host defense against infection. Initially identified through its potent bactericidal activity for Gram-negative bacteria, it is now known that CAP37 regulates numerous host cell functions, including corneal epithelial cell chemotaxis. Our long-term goal is to delineate the domains of CAP37 that define these functions and synthesize bioactive peptides for therapeutic use...
February 2015: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/25373777/cell-intrinsic-modulation-of-wnt-signaling-controls-neuroblast-migration-in-c-elegans
#17
Remco A Mentink, Teije C Middelkoop, Lorenzo Rella, Ni Ji, Chung Yin Tang, Marco C Betist, Alexander van Oudenaarden, Hendrik C Korswagen
Members of the Wnt family of secreted signaling proteins are key regulators of cell migration and axon guidance. In the nematode C. elegans, the migration of the QR neuroblast descendants requires multiple Wnt ligands and receptors. We found that the migration of the QR descendants is divided into three sequential phases that are each mediated by a distinct Wnt signaling mechanism. Importantly, the transition from the first to the second phase, which is the main determinant of the final position of the QR descendants along the anteroposterior body axis, is mediated through a cell-autonomous process in which the time-dependent expression of a Wnt receptor turns on the canonical Wnt/β-catenin signaling response that is required to terminate long-range anterior migration...
October 27, 2014: Developmental Cell
https://www.readbyqxmd.com/read/24696347/construction-of-dengue-virus-protease-expression-plasmid-and-in-vitro-protease-assay-for-screening-antiviral-inhibitors
#18
Huiguo Lai, Tadahisa Teramoto, Radhakrishnan Padmanabhan
Dengue virus serotypes 1-4 (DENV1-4) are mosquito-borne human pathogens of global significance causing ~390 million cases annually worldwide. The virus infections cause in general a self-limiting disease, known as dengue fever, but occasionally also more severe forms, especially during secondary infections, dengue hemorrhagic fever and dengue shock syndrome causing ~25,000 deaths annually. The DENV genome contains a single-strand positive sense RNA, approximately 11 kb in length. The 5'-end has a type I cap structure...
2014: Methods in Molecular Biology
https://www.readbyqxmd.com/read/24418596/-promoting-access-to-health-care-among-deaf-and-hard-of-hearing-youth-the-example-of-the-internet-training-workshops
#19
Marion Legeay, Jessica Saillard
Social inequalities in health remain a major problem in France despite recent efforts to improve access to prevention and care. In France, the reduction of inequalities involves many actors, including the Instances régionales d'éducation et de promotion de la santé (IREPS, the Regional Authorities for Health Education and Promotion). This paper focuses on health education for deaf and hard of hearing youth. The educational team responsible for providing health education among this population has highlighted the dangers of internet use among deaf and hard of hearing youth...
July 2013: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/24313084/-promoting-access-to-health-care-among-deaf-and-hard-of-hearing-youth-the-example-of-the-internet-training-workshops
#20
Marion Legeay, Jessica Saillard
Social inequalities in health remain a major problem in France despite recent efforts to improve access to prevention and care. In France, the reduction of inequalities involves many actors, including the Instances régionales d'education et de promotion de la santé (IREPS, the Regional Authorities for Health Education and Promotion). This paper focuses on health education for deaf and hard of hearing youth. The educational team responsible for providing health education among this population has highlighted the dangers of internet use among deaf and hard of hearing youth...
2013: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
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