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Alveolar macrophage

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https://www.readbyqxmd.com/read/29466392/differences-between-co-cultures-and-monocultures-in-testing-the-toxicity-of-particulate-matter-derived-from-log-wood-and-pellet-combustion
#1
Stefanie Kasurinen, Mikko S Happo, Teemu J Rönkkö, Jürgen Orasche, Jorma Jokiniemi, Miika Kortelainen, Jarkko Tissari, Ralf Zimmermann, Maija-Riitta Hirvonen, Pasi I Jalava
BACKGROUND: In vitro studies with monocultures of human alveolar cells shed deeper knowledge on the cellular mechanisms by which particulate matter (PM) causes toxicity, but cannot account for mitigating or aggravating effects of cell-cell interactions on PM toxicity. METHODS: We assessed inflammation, oxidative stress as well as cytotoxic and genotoxic effects induced by PM from the combustion of different types of wood logs and softwood pellets in three cell culture setups: two monocultures of either human macrophage-like cells or human alveolar epithelial cells, and a co-culture of these two cell lines...
2018: PloS One
https://www.readbyqxmd.com/read/29465071/-morphological-evaluation-of-singlet-phototherapy-in-the-treatment-of-periodontal-diseases-in-an-experimental-study
#2
E A Bazikyan, N V Syrnikova, A A Chunikhin, O V Zayratyants
The aim of the study was to compare the effectiveness of laser singlet phototherapy and traditional photodynamic therapy the treatment of periodontal diseases in an animal model. The experimental model involved 70 male rats Wistar in which periodontitis was modeled and treated: in group I (30 animals) a nanosecond laser device for medical use with a wavelength of 1270 nm was used for 7 sessions in a 400 ns pulse mode, an average radiation power of 2 W, and a radiation density of 200 J/cm2 , group II (30 animals) received photodynamic therapy with the administration of a photosensitizer, followed by irradiation with a laser wavelength of 660 nm for 7 sessions 2 Wt average radiation power, group III (controls, 10 animals) - traditional drug therapy...
2018: Stomatologii︠a︡
https://www.readbyqxmd.com/read/29462936/new-insights-into-the-immune-molecular-regulation-of-the-pathogenesis-of-acute-respiratory-distress-syndrome
#3
REVIEW
Chin-Yao Yang, Chien-Sheng Chen, Giou-Teng Yiang, Yeung-Leung Cheng, Su-Boon Yong, Meng-Yu Wu, Chia-Jung Li
Acute respiratory distress syndrome is an inflammatory disease characterized by dysfunction of pulmonary epithelial and capillary endothelial cells, infiltration of alveolar macrophages and neutrophils, cell apoptosis, necroptosis, NETosis, and fibrosis. Inflammatory responses have key effects on every phase of acute respiratory distress syndrome. The severe inflammatory cascades impaired the regulation of vascular endothelial barrier and vascular permeability. Therefore, understanding the relationship between the molecular regulation of immune cells and the pulmonary microenvironment is critical for disease management...
February 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29459175/-alveolar-hemorrhage-and-cocaine-use
#4
REVIEW
M Underner, J Perriot, B Wallaert, G Peiffer, J-C Meurice, N Jaafari
In France, cocaine is the second most commonly illicit drug used after cannabis. Cocaine, mainly smoked in the form of crack, can be responsible for a wide range of respiratory disorders. The aim of this systematic literature review was to clarify what is known about the link between cocaine use and alveolar hemorrhage. We performed a Medline search covering the period 1980-2016 and collected data from 84 articles. The number of acute forms described in the literature is small but postmortem studies show that hidden forms are frequent...
February 16, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29458975/the-interstitial-macrophage-a-long-neglected-piece-in-the-puzzle-of-lung-immunity
#5
REVIEW
Maude Liegeois, Celine Legrand, Christophe J Desmet, Thomas Marichal, Fabrice Bureau
Lung macrophages have mostly been studied considering only their most accessible and well-defined representative, the alveolar macrophage (AM). In contrast, the identity and putative immune functions of their tissue counterpart, the interstitial macrophage (IM), have long remained much more elusive. Yet, recent evidence supports the notion that IMs perform important immune functions in the lung, notably in terms of innate immunoregulation. Here, we review current knowledge on the phenotype, ontogeny and function of IMs and propose strategies for the unambiguous identification and study of this important and dynamic lung innate immune cell population...
February 8, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29458306/a-mechanistic-review-of-particle-overload-by-titanium-dioxide
#6
Hajime Kawasaki
Chronic exposure to titanium dioxide (TiO2 ) induces slight but significant pulmonary inflammation in experimental animals, and among potential mechanisms, particle overload is likely. Although mechanisms of particle overload are poorly understood, excess accumulation of dust particles in dust containing macrophages (dust cells) can impair their mobility, resulting in reduced clearance ability. Accordingly, retention half-times of inhaled TiO2 increase linearly with lung burden in rodents, and mathematical (Michaelis-Menten-like) models for pulmonary clearance rates of TiO2 as a function of lung burden have suggested an alternative mechanism for particle overload, involving excess accumulation of macrophages in the translocation pathway due to the narrow exit to the ciliated airway region, and leading to reduced pulmonary TiO2 clearance rates...
October 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29456535/liver-x-receptor-agonist-therapy-prevents-diffuse-alveolar-hemorrhage-in-murine-lupus-by-repolarizing-macrophages
#7
Shuhong Han, Haoyang Zhuang, Stepan Shumyak, Jingfan Wu, Chao Xie, Hui Li, Li-Jun Yang, Westley H Reeves
The generation of CD138+ phagocytic macrophages with an alternative (M2) phenotype that clear apoptotic cells from tissues is defective in lupus. Liver X receptor-alpha (LXRα) is an oxysterol-regulated transcription factor that promotes reverse cholesterol transport and alternative (M2) macrophage activation. Conversely, hypoxia-inducible factor 1-α (HIF1α) promotes classical (M1) macrophage activation. The objective of this study was to see if lupus can be treated by enhancing the generation of M2-like macrophages using LXR agonists...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29455917/respiratory-hazard-assessment-of-combined-exposure-to-complete-gasoline-exhaust-and-respirable-volcanic-ash-in-a-multicellular-human-lung-model-at-the-air-liquid-interface
#8
Ines Tomašek, Claire J Horwell, Christoph Bisig, David E Damby, Pierre Comte, Jan Czerwinski, Alke Petri-Fink, Martin J D Clift, Barbara Drasler, Barbara Rothen-Rutishauser
Communities resident in urban areas located near active volcanoes can experience volcanic ash exposures during, and following, an eruption, in addition to sustained exposures to high concentrations of anthropogenic air pollutants (e.g., vehicle exhaust emissions). Inhalation of anthropogenic pollution is known to cause the onset of, or exacerbate, respiratory and cardiovascular diseases. It is further postulated similar exposure to volcanic ash can also affect such disease states. Understanding of the impact of combined exposure of volcanic ash and anthropogenic pollution to human health, however, remains limited...
February 15, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29455859/heterozygous-mutations-in-oas1-cause-infantile-onset-pulmonary-alveolar-proteinosis-with-hypogammaglobulinemia
#9
Kazutoshi Cho, Masafumi Yamada, Kazunaga Agematsu, Hirokazu Kanegane, Noriko Miyake, Masahiro Ueki, Takuma Akimoto, Norimoto Kobayashi, Satoru Ikemoto, Mishie Tanino, Atsushi Fujita, Itaru Hayasaka, Satoshi Miyamoto, Mari Tanaka-Kubota, Koh Nakata, Masaaki Shiina, Kazuhiro Ogata, Hisanori Minakami, Naomichi Matsumoto, Tadashi Ariga
Pulmonary alveolar proteinosis (PAP) is characterized by accumulation of a surfactant-like substance in alveolar spaces and hypoxemic respiratory failure. Genetic PAP (GPAP) is caused by mutations in genes encoding surfactant proteins or genes encoding a surfactant phospholipid transporter in alveolar type II epithelial cells. GPAP is also caused by mutations in genes whose products are implicated in surfactant catabolism in alveolar macrophages (AMs). We performed whole-exome sequence analysis in a family affected by infantile-onset PAP with hypogammaglobulinemia without causative mutations in genes associated with PAP: SFTPB, SFTPC, ABCA3, CSF2RA, CSF2RB, and GATA2...
February 12, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29449834/peptidoglycan-recognition-protein-3-does-not-alter-the-outcome-of-pneumococcal-pneumonia-in-mice
#10
Anshu Shrivastav, Alexander N Dabrowski, Claudia Conrad, Nelli Baal, Holger Hackstein, Stephanie Plog, Kristina Dietert, Achim D Gruber, Philippe D N'Guessan, Sahar Aly, Norbert Suttorp, Janine Zahlten
Pneumococci frequently cause community-acquired pneumonia, a disease with high mortality rates, particularly in young children and in the elderly. Endogenous antimicrobial peptides and proteins such as PGLYRP3 may contribute to the progression and outcome of this disease. Since increasing antibiotic resistant strains occur all over the world, these endogenous antimicrobial molecules are interesting new targets for future therapies. In this study, the expression pattern of PGLYRP3 was analyzed in alveolar epithelial cells, alveolar macrophages and neutrophils...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29446321/pulmonary-il-1%C3%AE-expression-in-early-life-causes-permanent-changes-in-lung-structure-and-function-in-adulthood
#11
Anna Hogmalm, Maija Bry, Kristina Bry
Chorioamnionitis, mechanical ventilation, oxygen therapy, and postnatal infection promote inflammation in the newborn lung. The long-term consequences of pulmonary inflammation during infancy have not been well characterized. The aim of this study was to examine the impact of inflammation during the late saccular to alveolar stages of lung development on lung structure and function in adulthood. To induce IL-1β expression in the pulmonary epithelium of mice with a tetracycline-inducible human IL-1β transgene, doxycycline was administered via intraperitoneal injections to bitransgenic pups and their littermate controls on postnatal days (PN) 0, 0...
February 15, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29442228/effect-of-an-88-amino-acid-deletion-in-nsp2-of-porcine-reproductive-and-respiratory-syndrome-virus-on-virus-replication-and-cytokine-responses-in-vitro
#12
Wei He, Ying Wei, Jing Yao, Xin Xie, Jiabin Huang, Siyuan Lin, Kang Ouyang, Ying Chen, Weijian Huang, Zuzhang Wei
Previously, a spontaneous 88-amino-acid (aa) deletion in nsp2 was associated with cell-adaptation of porcine reproductive and respiratory syndrome virus (PRRSV) strain JXM100, which arose during passaging of the highly pathogenic PRRSV (HP-PRRSV) strain JX143 in MARC-145 cells. Here, to elucidate the biological role of this deletion, we specifically deleted the region of a cDNA clone of HP-PRRSV strain JX143 (pJX143) corresponding to these 88 amino acids. The effect of the deletion on virus replication in cultured cells and transcriptional activation of inflammatory cytokines and chemokines in pulmonary alveolar macrophages (PAMs) was examined...
February 13, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29438939/at-rvd1-repairs-mouse-lung-after-cigarette-smoke-induced-emphysema-via-downregulation-of-oxidative-stress-by-nrf2-keap1-pathway
#13
Sara Vergel Posso, Nicolas Quesnot, João Alfredo Moraes, Lycia Brito-Gitirana, Emanuel Kennedy-Feitosa, Marina Valente Barroso, Luís Cristóvão Porto, Manuella Lanzetti, Samuel Santos Valença
Long-term exposure to cigarette smoke (CS) results in alveolar parenchyma destruction due to chronic inflammatory response and the imbalance between oxidants and antioxidants, and proteases and antiproteases. Emphysema is the main symptom of chronic obstructive pulmonary disease. Current treatment focuses on relieving respiratory symptoms, and inflammation resolution failure is an important pathophysiological element of the disease. Specialized pro-resolving mediators (SPMs) synthesized endogenously during resolution processes demonstrated beneficial effects in murine models of airway inflammation...
February 10, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29435171/brucella-induces-unfolded-protein-response-and-inflammatory-response-via-gntr-in-alveolar-macrophages
#14
Dong Zhou, Fei-Jie Zhi, Mao-Zhen Qi, Fu-Rong Bai, Guangdong Zhang, Jun-Mei Li, Huan Liu, Hua-Tao Chen, Peng-Fei Lin, Ke-Qiong Tang, Wei Liu, Ya-Ping Jin, Ai-Hua Wang
Brucella is an intracellular bacterium that causes the zoonosis brucellosis worldwide. Alveolar macrophages (AM) constitute the main cell target of inhaled Brucella. Brucella thwarts immune surveillance and evokes endoplasmic reticulum (ER) stress to replicate in macrophages via virulence factors. The GntR regulators family was concentrated as an important virulence factor in controlling virulence and intracellular survival of Brucella. However, the detailed underlying mechanism for the host-pathogen interaction is poorly understood...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434585/the-activin-a-peroxisome-proliferator-activated-receptor-gamma-axis-contributes-to-the-transcriptome-of-gm-csf-conditioned-human-macrophages
#15
Concha Nieto, Rafael Bragado, Cristina Municio, Elena Sierra-Filardi, Bárbara Alonso, María M Escribese, Jorge Domínguez-Andrés, Carlos Ardavín, Antonio Castrillo, Miguel A Vega, Amaya Puig-Kröger, Angel L Corbí
GM-CSF promotes the functional maturation of lung alveolar macrophages (A-MØ), whose differentiation is dependent on the peroxisome proliferator-activated receptor gamma (PPARγ) transcription factor. In fact, blockade of GM-CSF-initiated signaling or deletion of the PPARγ-encoding gene PPARG leads to functionally defective A-MØ and the onset of pulmonary alveolar proteinosis. In vitro, macrophages generated in the presence of GM-CSF display potent proinflammatory, immunogenic and tumor growth-limiting activities...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29433439/legionella-effector-ankx-interacts-with-host-nuclear-protein-plekhn1
#16
Xiaobo Yu, Rebecca R Noll, Barbara P Romero Dueñas, Samual C Allgood, Kristi Barker, Jeffrey L Caplan, Matthias P Machner, Joshua LaBaer, Ji Qiu, M Ramona Neunuebel
BACKGROUND: The intracellular bacterial pathogen Legionella pneumophila proliferates in human alveolar macrophages, resulting in a severe pneumonia termed Legionnaires' disease. Throughout the course of infection, L. pneumophila remains enclosed in a specialized membrane compartment that evades fusion with lysosomes. The pathogen delivers over 300 effector proteins into the host cell, altering host pathways in a manner that sets the stage for efficient pathogen replication. The L. pneumophila effector protein AnkX targets host Rab GTPases and functions in preventing fusion of the Legionella-containing vacuole with lysosomes...
January 5, 2018: BMC Microbiology
https://www.readbyqxmd.com/read/29432836/quercetin-attenuates-the-hyperoxic-lung-injury-in-neonatal-mice-implications-for-bronchopulmonary-dysplasia-bpd
#17
Paramahamsa Maturu, Yanhong Wei-Liang, Vasilis P Androutsopoulos, Weiwu Jiang, Lihua Wang, Aristides M Tsatsakis, Xanthi I Couroucli
Quercetin (QU) is one of the most common flavonoids that are present in a wide variety of fruits, vegetables, and beverages. This compound possesses potent anti-inflammatory and anti-oxidant properties. Supplemental oxygen is routinely administered to premature infants with pulmonary insufficiency. However, hyperoxia is one of the major risk factors for the development of bronchopulmonary dysplasia (BPD), which is also termed chronic lung disease in premature infants. Currently, no preventive approaches have been reported against BPD...
February 9, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29428403/the-sonic-hedgehog-signaling-pathway-regulates-inferior-alveolar-nerve-regeneration
#18
Yurie Yamada, Atsushi Ohazama, Takeyasu Maeda, Kenji Seo
Activation of Shh signaling is known to be observed following injury of the peripheral nerves such as the sciatic nerve. However, the precise role of Shh signaling during peripheral nerve regeneration is not fully understood. The inferior alveolar nerve (IAN) is most commonly injured during oral surgery. Unlike the sciatic nerve, the IAN is isolated from other craniofacial tissues, as it resides in a long bony canal within the mandible. The IAN is thus an excellent experimental model for investigating peripheral nerve regeneration...
February 8, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29428392/mer-mediated-eosinophil-efferocytosis-regulates-resolution-of-allergic-airway-inflammation
#19
Jennifer M Felton, Christopher D Lucas, David A Dorward, Rodger Duffin, Tiina Kipari, Sonja Vermeren, Calum T Robb, Kenneth G MacLeod, Bryan Serrels, Jürgen Schwarze, Christopher Haslett, Ian Dransfield, Adriano G Rossi
BACKGROUND: Eosinophils play a central role in the propagation of allergic diseases including asthma. Both recruitment and retention of eosinophils regulate pulmonary eosinophilia but the question of whether alterations in apoptotic cell clearance by phagocytes directly contributes to resolution of allergic airway inflammation remains unexplored. OBJECTIVES: In this study we investigated the role of the receptor tyrosine kinase Mer in mediating apoptotic eosinophil clearance and allergic airway inflammation resolution in vivo in order to establish whether apoptotic cell clearance directly impacts upon the resolution of allergic airway inflammation...
February 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29427710/pathophysiology-of-peste-des-petits-ruminants-in-sheep-dorper-kajli-and-goats-boer-beetal
#20
Ahrar Khan, M Kashif Saleemi, Farah Ali, Muhammad Abubakar, Riaz Hussain, Rao Zahid Abbas, Imtiaz Ahmad Khan
Peste des petits ruminants (PPR), an economically important viral transboundary disease of small ruminants is not only prevalent in Pakistan but also in other countries where people rely on agriculture and animal products. The present study was aimed at describing the pathology and antigen localization in natural PPR infections in local (Kajli sheep; Beetal goats) as well as imported small ruminant breeds (Dorper sheep; Australian Boer goat). Morbidity and mortality rates were significantly (P < 0.001) higher in indigenous Kajli sheep (75...
February 7, 2018: Microbial Pathogenesis
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