Weixia Xuan, Shaohua Wang, Amarilys Alarcon-Calderon, Monique Simone Bagwell, Rachel Para, Faping Wang, Chujie Zhang, Xue Tian, Paul Stalboerger, Timothy Peterson, Michael Sabbah, Zeji Du, Tiffany Sarrafian, Ryan Mahlberg, Matt Hillestad, Skylar A Rizzo, Chris Paradise, Atta Behfar, Robert Vassallo
Chronic obstructive pulmonary disease (COPD) is a prevalent lung disease usually resulting from cigarette smoking (CS). Cigarette smoking induces oxidative stress, which causes inflammation and alveolar epithelial cell apoptosis, and represents a compelling therapeutic target for COPD. Human platelet-derived exosome product (PEP) is endowed with antioxidant enzymes and immunomodulatory molecules that mediate tissue repair. In this study, a murine model of CS-induced emphysema was used to determine whether nebulized PEP can influence the development of CS-induced emphysema through the mitigation of oxidative stress and inflammation in the lung...
February 5, 2024: Translational Research: the Journal of Laboratory and Clinical Medicine