keyword
https://read.qxmd.com/read/38537010/effect-of-egcg-based-paste-as-intracanal-dressing-in-mmps-2-and-9-expression-in-dog-s-periapical-lesions
#1
JOURNAL ARTICLE
Andiara De Rossi, Tadeu Pradela, Fernanda Souza Liévana, Raquel Assed Bezerra Segato, Jorge Esquiche León, Léa Assed Bezerra da Silva, Paulo Nelson-Filho
High expression of MMP-2 and MMP-9 in periapical lesions plays an important role in the degradation of the extracellular matrix. This study aimed to investigate the effect of epigallocatechin-3-gallate (EGCG)-based endodontic paste as an intracanal dressing on the expression of MMP-2 and MMP-9 in periapical lesions. Periapical lesions were experimentally induced in 35 mature beagle dog premolars randomly divided into healthy teeth, untreated periapical lesions, periapical lesions treated in a single session (control groups), and periapical lesions treated in two sessions with EGCG or calcium hydroxide-based pastes (experimental groups)...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38536105/osteoradionecrosis-in-a-torus-mandibularis-treated-by-antimicrobial-photodynamic-therapy-a-case-report
#2
JOURNAL ARTICLE
Maria Emília Mota, Marcia Martins Marques, Maria Stella Moreira, Nelise Alexandre da Silva Lascane
Background: Osteoradionecrosis (ORN) of the jaws is a late complication after radiotherapy to head and neck cancer. Objective: To describe a rare case of ORN of the torus mandibularis that was successfully managed exclusively with antimicrobial photodynamic therapy (aPDT). Case report: A 72-year-old man presented an exposed necrotic bone observed in the torus mandibularis, extending to the lingual alveolar ridge with no edema nor suppuration. The treatment provided a noninvasive treatment leading to spontaneous sequestrectomy of the torus in 2 weeks with complete mucosal repair in 5 weeks and absence of lesion signs and/or symptoms even after 6 months of follow-up...
March 27, 2024: Photobiomodulation, photomedicine, and laser surgery
https://read.qxmd.com/read/38532349/inhibition-of-zdhhc16-promoted-osteogenic-differentiation-and-reduced-ferroptosis-of-dental-pulp-stem-cells-by-creb
#3
JOURNAL ARTICLE
Wei Liu, Wenwei Yu, Lili Zhou, Danhua Ling, Yangbo Xu, Fuming He
BACKGROUND: The repair of bone defects caused by periodontal diseases is a difficult challenge in clinical treatment. Dental pulp stem cells (DPSCs) are widely studied for alveolar bone repair. The current investigation aimed to examine the specific mechanisms underlying the role of Zinc finger DHHC-type palmitoyl transferases 16 (ZDHHC16) in the process of osteogenic differentiation (OD) of DPSCs. METHODS: The lentiviral vectors ZDHHC16 or si-ZDHHC16 were introduced in the DPSCs and then the cells were induced by an odontogenic medium for 21 days...
March 26, 2024: BMC Oral Health
https://read.qxmd.com/read/38531928/green-tea-and-hyaluronic-acid-gel-enhance-fibroblast-activation-and-improves-the-gingival-healing-post-third-molar-extraction
#4
RANDOMIZED CONTROLLED TRIAL
Mariana da Silva Bonatto, Geórgia da Silva Feltran, Thamires Prazeres Barbosa, Davisson Alves Pereira, Samara de Souza Santos, Pedro Gomes Junqueira Mendes, Roberto Sales E Pessoa, Fábio José Barbosa Bezerra, Willian Fernando Zambuzzi, Guilherme José Pimentel Lopes de Oliveira
This study evaluates the effects of a green tea (Camellia sinensis) and hyaluronic acid gel on fibroblast activity and alveolar bone repair following third molar extractions. By examining the gene expression related to cell survival, proliferation, and angiogenesis, the study bridges in vitro findings with clinical outcomes in a split-mouth randomized trial. Human fibroblasts were exposed to the treatment gel, analysing gene expression through RT-qPCR. Twenty participants undergoing bilateral third molar extractions received the test gel on one side and a placebo on the other...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38529844/a-whole-course-repair-system-based-on-ros-glucose-stimuli-responsive-egcg-release-and-tunable-mechanical-property-for-efficient-treatment-of-chronic-periodontitis-in-diabetic-rats
#5
JOURNAL ARTICLE
Qingchen Feng, Mei Zhang, Guanning Zhang, Hongxiang Mei, Chongying Su, Lisa Liu, Xiaoxia Wang, Ziqianhong Wan, Zhengyi Xu, Liangkui Hu, Yu Nie, Juan Li
Elevated glucose levels, multiple pro-inflammatory cytokines and the generation of excessive reactive oxygen species (ROS) are pivotal characteristics within the microenvironments of chronic periodontitis with diabetes mellitus (CPDM). Control of inflammation and modulation of immune system are required in the initial phase of CPDM treatment, while late severe periodontitis requires a suitable scaffold to promote osteogenesis, rebuild periodontal tissue and reduce alveolar bone resorption. Herein, a whole-course-repair system is introduced by an injectable hydrogel using phenylboronic acid functionalized oxidized sodium alginate (OSA-PBA) and carboxymethyl chitosan (CMC)...
March 26, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38529490/an-injury-induced-tissue-niche-shaped-by-mesenchymal-plasticity-coordinates-the-regenerative-and-disease-response-in-the-lung
#6
Dakota L Jones, Michael P Morley, Xinyuan Li, Yun Ying, Fabian L Cardenas-Diaz, Shanru Li, Su Zhou, Sarah E Schaefer, Ullas V Chembazhi, Ana Nottingham, Susan Lin, Edward Cantu, Joshua M Diamond, Maria C Basil, Andrew E Vaughan, Edward E Morrisey
Severe lung injury causes basal stem cells to migrate and outcompete alveolar stem cells resulting in dysplastic repair and a loss of gas exchange function. This "stem cell collision" is part of a multistep process that is now revealed to generate an i njury-induced t issue ni ch e (iTCH) containing Keratin 5+ epithelial cells and plastic Pdgfra+ mesenchymal cells. Temporal and spatial single cell analysis reveals that iTCHs are governed by mesenchymal proliferation and Notch signaling, which suppresses Wnt and Fgf signaling in iTCHs...
February 29, 2024: bioRxiv
https://read.qxmd.com/read/38526790/crispr-cas9-mediated-bioluminescent-tagging-of-endogenous-proteins-by-fluorescent-protein-assisted-cell-sorting
#7
JOURNAL ARTICLE
Robert G Hawley, Teresa S Hawley
Oncogenic fusion genes are attractive therapeutic targets because of their tumor-specific expression and central "driver" roles in various human cancers. However, oncogenic fusions involving transcription factors such as PAX3-FOXO1 in alveolar fusion gene-positive rhabdomyosarcoma (FP-RMS) have been difficult to inhibit due to the apparent lack of tractable drug-like binding sites comparable to that recognized by Gleevec (imatinib mesylate) on the BCR-ABL1 tyrosine kinase fusion protein. Toward the identification of novel small molecules that selectively target PAX3-FOXO1, we used CRISPR-Cas9-mediated knock-in to append the pro-luminescent HiBiT tag onto the carboxy terminus of the endogenous PAX3-FOXO1 fusion protein in two human FP-RMS cell lines (RH4 and SCMC)...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38525010/electrospun-l-lysine-amorphous-calcium-phosphate-loaded-core-sheath-nanofibers-for-managing-oral-biofilm-infections-and-promoting-periodontal-tissue-repairment
#8
JOURNAL ARTICLE
Yufeng Ling, Menglu Duan, Wen Lyu, Jie Yang, Yu Liu, Shuangshuang Ren, Wenlei Wu
INTRODUCTION: Periodontitis, a chronic inflammatory disease prevalent worldwide, is primarily treated through GTR for tissue regeneration. The efficacy of GTR, however, remains uncertain due to potential infections and the intricate microenvironment of periodontal tissue. Herein, We developed a novel core-shell structure multifunctional membrane using a dual-drug-loaded coaxial electrospinning technique (Lys/ACP-CNF), contains L-lysine in the outer layer to aid in controlling biofilms after GTR regenerative surgery, and ACP in the inner layer to enhance osteogenic performance for accelerating alveolar bone repair...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38523167/identification-of-non-coding-rna-signatures-in-idiopathic-pulmonary-fibrosis
#9
JOURNAL ARTICLE
Alperen Elek, Esra Bozgeyik, Halil Caska, Zekihan Gocer, Ibrahim Bozgeyik
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a deadly, chronic, progressive, irreversible interstitial lung disease characterized by the formation of scar tissue resulting in permanent lung damage. The average survival time following diagnosis is only 3-5 years, with a 5-year survival rate shorter than that of many cancers. Alveolar epithelial cell injury followed by irregular repair is the primary pathological process observed in patients with IPF. An evident characteristic of IPF is the development of fibroblastic foci representing active fibrotic areas...
March 25, 2024: Irish Journal of Medical Science
https://read.qxmd.com/read/38521412/crucial-role-played-by-ck8-cells-in-mediating-alveolar-injury-remodeling-for-patients-with-covid-19
#10
JOURNAL ARTICLE
Yufeng Li, Hengrui Hu, Jia Liu, Longda Ma, Xi Wang, Liang Liu, Qian Liu, Liang Ren, Jiang Li, Fei Deng, Zhihong Hu, Yiwu Zhou, Manli Wang
The high risk of SARS-CoV-2 infection and reinfection and the occurrence of post-acute pulmonary sequelae have highlighted the importance of understanding the mechanism underlying lung repair after injury. To address this concern, comparative and systematic analyses of SARS-CoV-2 infection in COVID-19 patients and animals were conducted. In the lungs of nine patients who died of COVID-19 and one recovered from COVID-19 but died of unrelated disease in early 2020, damage-related transient progenitor (DATP) cells expressing CK8 marker proliferated significantly...
March 21, 2024: Virologica Sinica
https://read.qxmd.com/read/38516038/appreciable-biosafety-biocompatibility-and-osteogenic-capability-of-3d-printed-nonstoichiometric-wollastonite-scaffolds-favorable-for-clinical-translation
#11
JOURNAL ARTICLE
Yingming Wei, Zhongxiu Wang, Lihong Lei, Jiayin Han, Shuaiqi Zhong, Xianyan Yang, Zhongru Gou, Lili Chen
BACKGROUND: Alveolar bone destruction due to periodontal disease often requires a bone graft substitute to reconstruct the anatomical structures and biological functions of the bone tissue. Despite significant advances in the development of foreign ion-doped nonstoichiometric wollastonite bioceramics (CaSiO3 , nCSi) for alveolar bone regeneration over the past decade, the in vivo biosafety and osteogenesis of nCSi scaffolds remain uncertain. In this study, we developed a customized porous nCSi scaffold to investigate the in vivo biocompatibility and osteogenic properties of nCSi bioceramics...
March 2024: Journal of Orthopaedic Translation
https://read.qxmd.com/read/38513841/role-of-macrophage-bioenergetics-in-n-acetylcysteine-mediated-mitigation-of-lung-injury-and-oxidative-stress-induced-by-nitrogen-mustard
#12
JOURNAL ARTICLE
Rama Malaviya, Jaclynn Meshanni, Vasanthi R Sunil, Alessandro Venosa, Changjiang Guo, Elena V Abramova, Kinal N Vayas, Chenghui Jiang, Jessica A Cervelli, Andrew J Gow, Jeffrey D Laskin, Debra L Laskin
Nitrogen mustard (NM) is a toxic vesicant that causes acute injury to the respiratory tract. This is accompanied by an accumulation of activated macrophages in the lung and oxidative stress which have been implicated in tissue injury. In these studies, we analyzed the effects of N-acetylcysteine (NAC), an inhibitor of oxidative stress and inflammation on NM-induced lung injury, macrophage activation and bioenergetics. Treatment of rats with NAC (150 mg/kg, i.p., daily) beginning 30 min after administration of NM (0...
March 19, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38509204/erythropoietin-receptor-signal-is-crucial-for-periodontal-ligament-stem-cell-based-tissue-reconstruction-in-periodontal-disease
#13
JOURNAL ARTICLE
Mhd Fouad Zakaria, Soichiro Sonoda, Hiroki Kato, Lan Ma, Norihisa Uehara, Yukari Kyumoto-Nakamura, M Majd Sharifa, Liting Yu, Lisha Dai, Erika Yamauchi-Tomoda, Reona Aijima, Haruyoshi Yamaza, Fusanori Nishimura, Takayoshi Yamaza
Alveolar bone loss caused by periodontal disease eventually leads to tooth loss. Periodontal ligament stem cells (PDLSCs) are the tissue-specific cells for maintaining and repairing the periodontal ligament, cementum, and alveolar bone. Here, we investigated the role of erythropoietin receptor (EPOR), which regulates the microenvironment-modulating function of mesenchymal stem cells, in PDLSC-based periodontal therapy. We isolated PDLSCs from patients with chronic periodontal disease and healthy donors, referred to as PD-PDLSCs and Cont-PDLSCs, respectively...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38486338/effectiveness-of-extracellular-vesicles-derived-from-hipscs-in-repairing-hyperoxia-induced-injury-in-a-fetal-murine-lung-explant-model
#14
JOURNAL ARTICLE
Hala Saneh, Heather Wanczyk, Joanne Walker, Christine Finck
BACKGROUND: Despite advances in neonatal care, the incidence of Bronchopulmonary Dysplasia (BPD) remains high among preterm infants. Human induced pluripotent stem cells (hiPSCs) have shown promise in repairing injury in animal BPD models. Evidence suggests they exert their effects via paracrine mechanisms. We aim herein to assess the effectiveness of extracellular vesicles (EVs) derived from hiPSCs and their alveolar progenies (diPSCs) in attenuating hyperoxic injury in a preterm lung explant model...
March 14, 2024: Stem Cell Research & Therapy
https://read.qxmd.com/read/38477792/lepr-stromal-cells-respond-to-periodontitis-and-attenuate-alveolar-bone-repair-via-ccrl2-mediated-wnt-inhibition
#15
JOURNAL ARTICLE
Yongliang Chen, Yuteng Weng, Jie Huang, Qin Li, Bin Sun, Haicheng Wang, Zuolin Wang
The impaired bone healing in tooth extraction sockets due to periodontitis presents a major obstacle to restoring oral health. The mechanisms regulating osteogenic capacity of jawbone derived stromal cells in periodontitis microenvironment remain elusive. Leptin receptor (LepR) expressing stromal cells, which largely overlap with Cxcl12-abundant reticular (CAR) cells in bone tissue, rapidly proliferate and differentiate into bone-forming cells during extraction socket healing to support alveolar bone repair...
March 12, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38476514/virtual-surgical-planning-in-condyle-reconstruction-of-posterior-mandibulectomy-defects
#16
Katherine C Benedict, Ignacio Velasco Martinez, Benjamin McIntyre
BACKGROUND: Ameloblastoma is a rare odontogenic tumor most commonly located within the mandible. These tumors can grow to massive proportions and result in malocclusion. Segmental mandibulectomy and reconstruction with an osteocutaneous free flap are frequently required. Virtual surgical planning (VSP) aids the surgeon in creating precise anatomic reconstruction when there is preoperative malocclusion due to tumor size. In this study we seek to further examine reconstruction of posterior mandibulectomy defects inclusive of condylar resection...
2024: Eplasty
https://read.qxmd.com/read/38476262/deciphering-the-impacts-of-modulating-the-wnt-planar-cell-polarity-pcp-pathway-on-alveolar-repair
#17
JOURNAL ARTICLE
Sally Yunsun Kim, David McTeague, Sek-Shir Cheong, Matthew Hind, Charlotte H Dean
Many adult lung diseases involve dysregulated lung repair. Deciphering the molecular and cellular mechanisms that govern intrinsic lung repair is essential to develop new treatments to repair/regenerate the lungs. Aberrant Wnt signalling is associated with lung diseases including emphysema, idiopathic pulmonary fibrosis and pulmonary arterial hypertension but how Wnt signalling contributes to these diseases is still unclear. There are several alternative pathways that can be stimulated upon Wnt ligand binding, one of these is the Planar Cell Polarity (PCP) pathway which induces actin cytoskeleton remodelling...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38470443/effects-of-coriander-on-the-repair-process-of-experimentally-induced-periodontitis-in-rats
#18
JOURNAL ARTICLE
Umut Ballı, Şeyma Bozkurt Doğan, Figen Öngöz Dede, Kanat Gülle, Hatice Çölgeçen, Bahattin Avcı, Meryem Akpolat Ferah, M Bülent Kurtiş
The aim of this study was to evaluate the effects of Coriandrum sativum L. (CSL) seed extract on gingival levels of antioxidant enzymes, pro-inflammatory cytokines and on alveolar bone and attachment levels after experimental periodontitis induction in rats and compare it with low-dose doxycycline (LDD). Forty adult male Wistar Albino rats were divided randomly into 5 groups as follows: 1 = periodontally healthy (control); 2 = periodontitis; 3 = periodontitis + CSL (32 mg/kg); 4 = periodontitis + CSL (200 mg/kg); and 5 = periodontitis + LDD (6 mg/kg)...
March 12, 2024: Journal of Veterinary Dentistry
https://read.qxmd.com/read/38461271/two-stage-palatal-repair-in-non-syndromic-clp-patients-using-anterior-to-posterior-closure-is-associated-with-minimal-need-for-secondary-palatal-surgery
#19
JOURNAL ARTICLE
Philipp Kauffmann, Johanna Kolle, Anja Quast, Susanne Wolfer, Boris Schminke, Philipp Meyer-Marcotty, Henning Schliephake
OBJECTIVE: The aim of the present study was to assess the need for secondary palatal corrective surgery in a concept of palate repair that uses a protocol of anterior to posterior closure of primary palate, hard palate and soft palate. METHODS: A data base of patients primarily operated between 2001 and 2021 at the Craniofacial and Cleft Care Center of the University Goettingen was evaluated. Cleft lips had been repaired using Tennison Randall and Veau-Cronin procedures in conjunction with alveolar cleft repair...
March 9, 2024: Head & Face Medicine
https://read.qxmd.com/read/38444763/function-of-kvlqt1-potassium-channels-in-a-mouse-model-of-bleomycin-induced-acute-lung-injury
#20
JOURNAL ARTICLE
Mélissa Aubin Vega, Alban Girault, Émilie Meunier, Jasmine Chebli, Anik Privé, Annette Robichaud, Damien Adam, Emmanuelle Brochiero
Acute respiratory distress syndrome (ARDS) is characterized by an exacerbated inflammatory response, severe damage to the alveolar-capillary barrier and a secondary infiltration of protein-rich fluid into the airspaces, ultimately leading to respiratory failure. Resolution of ARDS depends on the ability of the alveolar epithelium to reabsorb lung fluid through active transepithelial ion transport, to control the inflammatory response, and to restore a cohesive and functional epithelium through effective repair processes...
2024: Frontiers in Physiology
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