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Alveolar repair

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https://www.readbyqxmd.com/read/29781248/the-role-of-3d-printing-in-treating-craniomaxillofacial-congenital-anomalies
#1
REVIEW
Christopher D Lopez, Lukasz Witek, Andrea Torroni, Roberto L Flores, David B Demissie, Simon Young, Bruce N Cronstein, Paulo G Coelho
Craniomaxillofacial congenital anomalies comprise approximately one third of all congenital birth defects and include deformities such as alveolar clefts, craniosynostosis, and microtia. Current surgical treatments commonly require the use of autogenous graft material which are difficult to shape, limited in supply, associated with donor site morbidity and cannot grow with a maturing skeleton. Our group has demonstrated that 3D printed bio-ceramic scaffolds can generate vascularized bone within large, critical-sized defects (defects too large to heal spontaneously) of the craniomaxillofacial skeleton...
May 20, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29779212/periodontal-regeneration-via-chemo-attractive-constructs
#2
Xinjie Cai, Fang Yang, X Frank Walboomers, Yining Wang, John A Jansen, Jeroen J J P van den Beucken, Adelina S Plachokova
AIM: Chemo-attractants, such as stromal cell-derived factor-1α (SDF-1α), can offer an advantage for periodontal regeneration by recruiting the patient's own stem cells to stimulate self-repair. We here developed a chemo-attractive construct for periodontal regeneration using SDF-1α and evaluated its efficacy in vivo. MATERIALS AND METHODS: SDF-1α was loaded on gelatin sponge and tested in vitro for SDF-1α release. Subsequently, SDF-1α constructs were implanted into rat periodontal defects for 1 and 6 weeks, with unloaded materials and empty defects as controls...
May 19, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29777942/photomodulation-multiple-sessions-as-a-promising-preventive-therapy-for-medication-related-osteonecrosis-of-the-jaws-after-tooth-extraction-in-rats
#3
Cristian Statkievicz, Luan Felipe Toro, João Martins de Mello-Neto, Daniela Pereira de Sá, Cláudio Aparecido Casatti, João Paulo Mardegan Issa, Luciano Tavares Angelo Cintra, Juliano Milanezi de Almeida, Maria José Hitomi Nagata, Valdir Gouveia Garcia, Leticia Helena Theodoro, Edilson Ervolino
The aim of this study was to evaluate the effects of photobiomodulation (PBM) with multiple sessions of low-level laser on the alveolar repair process of rats with major risk factors for medication-related osteonecrosis of the jaws (MRONJ). Senile rats received 0.45 mL of vehicle (VEH and VEH-PBM) or 0.45 mL of 100 μg/kg zoledronate (ZOL and ZOL-PBM) administrated intraperitoneally every two days during seven weeks. After three weeks of initiation of drug treatment the first lower left molar was extracted...
May 9, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29773402/hydroxypropylmethyl-cellulose-hpmc-crosslinked-chitosan-ch-based-scaffolds-containing-bioactive-glass-bg-and-zinc-oxide-zno-for-alveolar-bone-repair
#4
Rabia Zeeshan, Zeeshan Mutahir, Haffsah Iqbal, Moazzam Ali, Farasat Iqbal, Kashif Ijaz, Faiza Sharif, Asma Tufail Shah, Aqif Anwar Chaudhry, Muhammad Yar, Shifang Luan, Ather Farooq Khan, Ihtesham-Ur-Rehman
The success of a dental implant relies on the presence of an optimal alveolar ridge. The aim of this study was to fabricate HPMC crosslinked chitosan based scaffolds for alveolar bone repair. Our results indicated that HPMC crosslinked CH/BG foams presented better morphological structure (132-90.5 μm) and mechanical responses (0.451 MPa with 100 mg BG) as confirmed by SEM analysis and fatigue testing respectively. Cytotoxicity analysis at day 2, 4 and 8 demonstrated that all composites were non-toxic and supported cellular viability...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29755801/central-hypoventilation-a-rare-complication-of-wallenberg-syndrome
#5
Keithan Sivakumar, Manveer Garcha, Dev Mehta, Megan C Leary, Hussam A Yacoub
Central alveolar hypoventilation disorders denote conditions resulting from underlying neurologic disorders affecting the sensors, the central controller, or the integration of those signals leading to insufficient ventilation and reduction in partial pressures of oxygen. We report a patient who presented with a left lateral medullary ischemic stroke after aneurysm repair who subsequently developed a rare complication of CAH. Increased awareness of this condition's clinical manifestations is crucial to make an accurate diagnosis and understand its complications and prognosis...
2018: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29750729/posterior-lamellar-reconstruction-of-the-lower-eyelid-with-a-gingivoalveolar-mucosal-graft
#6
Yahya Baltu
The anterior and posterior lamellae should be simultaneously reconstructed to repair the upper and lower eyelid's full thickness defects after resection of a malignant tumor. The author described a gingivoalveolar mucosal graft for posterior lamellar reconstruction of the lower eyelid. Between November 2014 and September 2017, 11 patients (6 women, 5 men; mean age 62.7 years) with 13 posterior lamellar defect of lower eyelid underwent reconstruction with gingivoalveolar mucosal graft. The defects ranged from 10 x 8 mm to 20 x 10 mm...
May 10, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29750093/laser-phototherapy-induces-angiogenesis-in-the-periodontal-tissue-after-delayed-tooth-replantation-in-rats
#7
Felipe-de Souza Matos, Fernanda-de Jesus Godolphim, Ricardo-Luiz-Cavalcanti Albuquerque-Júnior, Luiz-Renato Paranhos, Sigmar-de Mello Rode, Cláudio-Antonio-Talge Carvalho, Maria-Amália-Gonzaga Ribeiro
Background: Laser phototherapy (LPT) has been suggested as a new therapeutic tool to improve the repair of replanted teeth. However, its effects and mechanism of action are not yet completely understood. Objectives: This study evaluated histologically the effect of laser phototherapy (LPT) λ808 and λ660 nm on angiogenesis in the periodontal tissue of replanted teeth in rats. Material and Methods: Twenty maxillary right incisors were extracted from twenty Wistar rats and randomly assigned to four groups (n = 5): PN - teeth were stored in paper napkin for 45 min; WM - teeth were immersed in 20 ml of UHT whole cow milk for 45 min; PNL and WML - teeth received the same treatment described for PN and WM, respectively, plus LPT at λ808 and λ660 nm...
April 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29745252/changes-in-the-pattern-of-fibrosis-in-the-rat-lung-with-repetitive-orotracheal-instillations-of-gastric-contents-evidence-of-persistent-collagen-accumulation
#8
Pedro Ayala, Jorge Torres, Raul Vivar, Pablo R Olmos, Manuel Meneses, Gisella R Borzone
Recurrent aspiration of gastric contents has been associated with several interstitial lung diseases. Despite this association, the pathogenic role of aspiration in these diseases has been poorly studied and little is known about extracellular matrix (ECM) changes in animal models of repetitive events of aspiration. Our aim was to study the repair phase of lung injury induced by each of several instillations of gastric fluid in Sprague-Dawley rats to evaluate changes in ECM and their reversibility. Anesthetized animals received weekly orotracheal instillations of gastric fluid for 1, 2, 3 and 4 weeks and were sacrificed at day 7 after last instillation...
May 10, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29738746/histological-and-histomorphometric-response-to-socketkap%C3%A2-and-socketkage%C3%A2-used-for-ridge-preservation-and-repair-results-from-a-randomized-controlled-clinical-trial
#9
Neema Bakhshalian, Alaa Abdelhamid, Yoon Jeong Park, Homayoun H Zadeh
PURPOSE: This study investigated the histologic tissue response to SocketKAP and SocketKAGE as novel devices designed for ridge preservation. MATERIALS AND METHODS: This randomized controlled clinical trial recruited participants from among patients who presented to a university dental clinic. The study protocol entailed randomization into 5 intervention groups after tooth extraction: unassisted healing of intact sockets (group A), SocketKAP (group B), anorganic bovine bone minerals (ABBM) plus SocketKAP (group C), unassisted healing of sockets with dehiscence (group D), and SocketKAGE plus ABBM plus SocketKAP (group E)...
April 12, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29731780/lung-mesenchymal-stem-cells-ameliorate-elastase-induced-damage-in-an-animal-model-of-emphysema
#10
Donato Cappetta, Antonella De Angelis, Giuseppe Spaziano, Gioia Tartaglione, Elena Piegari, Grazia Esposito, Loreta Pia Ciuffreda, Angela Liparulo, Manuela Sgambato, Teresa Palmira Russo, Francesco Rossi, Liberato Berrino, Konrad Urbanek, Bruno D'Agostino
Pulmonary emphysema is a respiratory condition characterized by alveolar destruction that leads to airflow limitation and reduced lung function. Although with extensive research, the pathophysiology of emphysema is poorly understood and effective treatments are still missing. Evidence suggests that mesenchymal stem cells (MSCs) possess the ability to engraft the injured tissues and induce repair via a paracrine effect. Thus, the aim of this study was to test the effects of the intratracheal administration of lung-derived mouse MSCs in a model of elastase-induced emphysema...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29730892/activation-of-p70s6-kinase-1-in-mesenchymal-stem-cells-is-essential-to-lung-tissue-repair
#11
Katsuyuki Takeda, Fangkun Ning, Joanne Domenico, Masakazu Okamoto, Shigeru Ashino, Sang-Ha Kim, Yi Yeong Jeong, Yoshiki Shiraishi, Naohiro Terada, Everett Rand Sutherland, Erwin W Gelfand
All-trans retinoic acid (ATRA) or mesenchymal stem cells (MSCs) have been shown to promote lung tissue regeneration in animal models of emphysema. However, the reparative effects of the combination of the two and the role of p70S6 kinase-1 (p70S6k1) activation in the repair process have not been defined. Twenty-one days after intratracheal instillation of porcine pancreatic elastase (PPE), MSC and/or 10 days of ATRA treatment was initiated. Thirty-two days later, static lung compliance (Cst), mean linear intercepts (MLIs), and alveolar surface area (S) were measured...
May 5, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29722336/mitochondrial-autophagy-and-nlrp3-inflammasome-in-pulmonary-tissues-from-severe-combined-immunodeficient-mice-after-cardiac-arrest-and-cardiopulmonary-resuscitation
#12
Jing-Jun Lyu, Jawahar L Mehta, Yi Li, Lu Ye, Sheng-Nan Sun, Hong-Shuang Sun, Jia-Chang Li, Dong-Mei Zhang, Jie Wei
Background: The incidence of cancer, diabetes, and autoimmune diseases has been increasing. Furthermore, there are more and more patients with solid organ transplants. The survival rate of these immunocompromised individuals is extremely low when they are severely hit-on. In this study, we established cardiac arrest cardiopulmonary resuscitation (CPR) model in severe combined immunodeficient (SCID) mice, analyzed the expression and activation of mitochondrial autophagy and NLRP3 inflammasome/caspase-1, and explored mitochondrial repair and inflammatory injury in immunodeficiency individual during systemic ischemia-reperfusion injury...
May 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29719298/mesenchymal-stromal-cells-to-regenerate-emphysema-on-the-horizon
#13
Dennis M L W Kruk, Irene H Heijink, Dirk-Jan Slebos, Wim Timens, Nick H Ten Hacken
Mesenchymal stem or stromal cells (MSCs) are multipotent cells that play a pivotal role in various phases of lung development and lung homeostasis, and potentially also lung regeneration. MSCs do not only self-renew and differentiate into renew tissues, but also have anti-inflammatory and paracrine properties to reduce damage and to support tissue regeneration, constituting a promising cell-based treatment strategy for the repair of damaged alveolar tissue in emphysema. This review discusses the current state of the art regarding the potential of MSCs for the treatment of emphysema...
May 2, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29713167/characterization-and-evaluation-of-graphene-oxide-scaffold-for-periodontal-wound-healing-of-class-ii-furcation-defects-in-dog
#14
Kohei Kawamoto, Hirofumi Miyaji, Erika Nishida, Saori Miyata, Akihito Kato, Akito Tateyama, Tomokazu Furihata, Kanako Shitomi, Toshihiko Iwanaga, Tsutomu Sugaya
Introduction: The 3-dimensional scaffold plays a key role in volume and quality of repair tissue in periodontal tissue engineering therapy. We fabricated a novel 3D collagen scaffold containing carbon-based 2-dimensional layered material, named graphene oxide (GO). The aim of this study was to characterize and assess GO scaffold for periodontal tissue healing of class II furcation defects in dog. Materials and methods: GO scaffolds were prepared by coating the surface of a 3D collagen sponge scaffold with GO dispersion...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29705120/incidence-of-reactive-hyperplastic-lesions-in-the-oral-cavity-a-10-year-retrospective-study-in-santa-catarina-brazil
#15
Kamile Leonardi Dutra, Lunardo Longo, Liliane Janete Grando, Elena Riet Correa Rivero
INTRODUCTION: Reactive hyperplastic lesions develop in response to a chronic injury simulating an exuberant tissue repair response. They represent some of the most common oral lesions including inflammatory fibrous hyperplasia, oral pyogenic granuloma, giant cell fibroma, peripheral ossifying fibroma, and peripheral giant cell lesions. OBJECTIVE: The incidence of those lesions was investigated in an oral pathology service, and the clinical characteristics, associated etiological factors, concordance between the clinical and histopathological diagnostic was determined...
April 17, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29704698/an-osteopenic-osteoporotic-phenotype-delays-alveolar-bone-repair
#16
Chih-Hao Chen, Liao Wang, U Serdar Tulu, Masaki Arioka, Melika Maghazeh Moghim, Benjamin Salmon, Chien-Tzung Chen, Waldemar Hoffmann, Jessica Gilgenbach, John B Brunski, Jill A Helms
Aging is associated with a function decline in tissue homeostasis and tissue repair. Aging is also associated with an increased incidence in osteopenia and osteoporosis, but whether these low bone mass diseases are a risk factor for delayed bone healing still remains controversial. Addressing this question is of direct clinical relevance for dental patients, since most implants are performed in older patients who are at risk of developing low bone mass conditions. The objective of this study was to assess how an osteopenic/osteoporotic phenotype affected the rate of new alveolar bone formation...
April 25, 2018: Bone
https://www.readbyqxmd.com/read/29690697/-experimental-study-on-the-transforming-growth-factor-%C3%AE-3-combined-with-dental-pulp-stem-cells-in-early-bone-integration-of-implant
#17
Ababaikeli Guzalinuer, Huojia Muhetaer, H Wu, Abudureheman Paerhati
Objective: To establish the experimental model of rabbit mandibular anterior implant repair and evaluate the effects of transforming growth factor (TGF)-β3 and dental pulp stem cells (DPSC) in promoting the bone integration of implant. Methods: The New Zealand rabbits were randomly divided into experimental group, control group and blank group (6 rabbits for each group) . In the experimental group, the implant area was filled with the mixture of TGF-β3, DPSC and Bio-oss powder. In the control group, the implant area was filled with the mixture of DPSC and Bio-oss powder...
April 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29683754/micrornas-in-idiopathic-pulmonary-fibrosis-new-research-progress-and-their-pathophysiological-implication
#18
Chenggui Miao, Youyi Xiong, Guoxue Zhang, Jun Chang
Many studies have shown that microRNAs (miRNAs) play important roles in the development of idiopathic pulmonary fibrosis (IPF). The purpose of this review is to systematically summarize the recent advance of miRNAs in the pathology of IPF, highlighting the new research progress and their pathophysiological implication. Recent studies have shown that miRNAs differentially expressed in blood and lung tissue from IPF patients are closely related to the occurrence of IPF disease, which may be IPF diagnostic markers and prognostic indicators...
April 23, 2018: Experimental Lung Research
https://www.readbyqxmd.com/read/29672287/early-administration-of-magnesium-sulfate-during-open-fetal-myelomeningocele-repair-reduces-the-dose-of-inhalational-anesthesia
#19
Roopali Donepudi, Melissa Huynh, Kenneth J Moise, Ramesha Papanna, Anthony Johnson, Mary Austin, KuoJen Tsao, Ranu Jain
INTRODUCTION: Optimal uterine relaxation is achieved through higher minimum alveolar concentration (MAC) of inhalational anesthetics, increasing risks to mother and fetus. Our objective was to determine if earlier administration of magnesium sulfate would reduce the requirement of inhalational anesthetics in fetal myelomeningocele repair. MATERIALS AND METHODS: Prospective observational study of fetal myelomeningocele repair was performed from September 2011 to August 2017...
April 19, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29664060/specialized-pro-resolving-mediators-regulate-alveolar-fluid-clearance-during-acute-respiratory-distress-syndrome
#20
REVIEW
Qian Wang, Song-Fan Yan, Yu Hao, Sheng-Wei Jin
Objective: Acute respiratory distress syndrome (ARDS) is an acute and lethal clinical syndrome that is characterized by the injury of alveolar epithelium, which impairs active fluid transport in the lung, and impedes the reabsorption of edema fluid from the alveolar space. This review aimed to discuss the role of pro-resolving mediators on the regulation of alveolar fluid clearance (AFC) in ARDS. Data Sources: Articles published up to September 2017 were selected from the PubMed, with the keywords of "alveolar fluid clearance" or "lung edema" or "acute lung injury" or "acute respiratory distress syndrome", and "specialized pro-resolving mediators" or "lipoxin" or "resolvin" or "protectin" or "maresin" or "alveolar epithelial cells" or "aspirin-triggered lipid mediators" or "carbon monoxide and heme oxygenase" or "annexin A1"...
April 20, 2018: Chinese Medical Journal
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