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Alveolar repair

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https://www.readbyqxmd.com/read/28333899/-stem-progenitor-cells-in-diseases-of-the-respiratory-tract
#1
EDITORIAL
Tadeusz Płusa
Stem cells (SCs - stem cells) are characterized by plasticity and the ability to differentiate into other cell types. They are obtained from bone marrow, peripheral blood and cord blood. Mesenchymal stem cells (MSCs) shows a broad immunomodulating, increases the number of regulatory T cells (Treg), modifies the activity of T cells, dendritic cells and NK (natural killer). Direct impact on reducing the release of proinflammatory cytokines and increased release of proinflammatory cytokines. Within the respiratory tract has a number of resident stem and progenitor cells referred to as L-MSCs (lung mesenchymal stem cells) whose presence was confirmed by markers as defined in the trachea, epithelial cells and alveolar...
March 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28326722/-application-of-team-approach-and-key-techniques-of-cleft-lip-and-palate
#2
Shi Bing, Fu Yuchuan, Yin Ningbei, Huang Hong-Zhang, Liu Jianhua, Chen Renji, Zhu Hongping, Liu Qiang, Huang Yongqing, Ren Zhanping, Lu Yong, Xiao Wenlin, Song Qinggao, Li Wanshan, Li Sheng, Wang Hongtao, Zhang Junrui, Jiang Liping, Ma Li, Wang Ling, He Dengqi
The development of an expert consensus based on specific domestic situations will provide practical guidance to the efforts aiming at improving cleft care in China. The team approach of twenty-one cleft centers were pooled together, covering pre-surgical orthopedics, primary surgical repair, orthodontic treatment, alveolar bone graft, secondary deformity correction, palatal fistulae repair, the diagnosis and treatment of velopharyngeal incompetence, speech therapy, otitis media management, and skeletal deformity correction...
February 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28317353/-clinical-application-on-restoration-of-dentition-defects-using-tooth-alveolar-bone-grafts
#3
Chen Zhifang, Zhang Wei
OBJECTIVE: To evaluate the clinical effectiveness of tooth-alveolar bone grafts in repairing dentition defects. METHODS: Forty-five patients with dentition defect were divided into two groups according to different operation methods. In group A (n=24), the tooth-alveolar bone grafts of the transplanted tooth and its surrounding alveolar bone were cut using modified surgical orthodontics and then embedded into the designated planting hole. In group B (n=21), the teeth were extracted through conventional tooth transplantation and then embedded into the prepared planting holes...
August 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28314802/an-ex-vivo-model-to-induce-early-fibrosis-like-changes-in-human-precision-cut-lung-slices
#4
Hani N Alsafadi, Claudia A Staab-Weijnitz, Mareike Lehmann, Michael Lindner, Britta Peschel, Melanie Königshoff, Darcy Elizabeth Wagner
IPF is a devastating chronic interstitial lung disease (ILD) characterized by lung tissue scarring and high morbidity. Lung epithelial injury, myofibroblast activation, and deranged repair are believed to be key processes involved in disease onset and progression but the exact molecular mechanisms behind IPF remain unclear. Several drugs have been shown to slow disease progression, but treatments which halt or reverse IPF progression have not been identified. Ex vivo models of human lung have been proposed for drug discovery, one of which is precision-cut lung slices (PCLS)...
March 17, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28296468/foxp3-regulatory-t-cell-expression-of-keratinocyte-growth-factor-enhances-lung-epithelial-proliferation
#5
Catherine F Dial, Miriya K Tune, Claire M Doerschuk, Jason R Mock
Repair of the lung epithelium after injury is a critical component for resolution; however, the processes necessary to drive epithelial resolution are not clearly defined. Published data demonstrate that Foxp3+ regulatory T cells (Tregs) enhance alveolar epithelial proliferation after injury, and Tregs in vitro directly promote type II alveolar epithelial cell (AT2) proliferation in part by a contact-independent mechanism. Therefore, we sought to determine the contribution of Treg-specific expression of a growth factor, keratinocyte growth factor (Kgf), known to be important in lung repair...
March 15, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28292342/a-comparison-of-mixed-dentition-dental-development-in-cleft-patients-treated-with-and-without-the-latham-type-appliance
#6
Jin Lin, Veerasathpurush Allareddy, Elizabeth Ross, Stephen Shusterman
PURPOSE: The purpose of this study was to retrospectively evaluate the Latham-type appliance's effect on the development and eruption of posterior teeth during the mixed dentition stage before palatal expansion and secondary alveolar bone graft(s). METHODS: The charts of complete cleft lip and palate (CLP) patients treated with and without the Latham-type appliance were screened using the following inclusion criteria: nonsyndromic; CLP; and available panoramic radiographs and clinical photographs in the mixed dentition prior to palatal expansion and secondary alveolar bone grafts...
January 15, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/28291398/periodontal-therapy-in-dogs-using-bone-augmentation-products-marketed-for-veterinary-use
#7
Molly Angel
Periodontal disease is extremely common in companion animal practice. Patients presenting for a routine oral examination and prophylaxis may be found to have extensive periodontal disease and attachment loss. Vertical bone loss is a known sequela to periodontal disease and commonly involves the distal root of the mandibular first molar. This case report outlines two dogs presenting for oral examination and prophylaxis with general anesthesia. Both patients did not have any clinical symptoms of periodontal disease other than halitosis...
March 14, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28267436/management-of-persistent-air-leaks
#8
REVIEW
Karen C Dugan, Balaji Laxmanan, Septimiu Murgu, D Kyle Hogarth
Alveolar-pleural fistulas causing persistent air leaks are associated with prolonged hospital stays and high morbidity. Prior guidelines recommend surgical repair as the gold standard for treatment, albeit a solution with limited success. In patients who have recently undergone thoracic surgery or in which surgery would be contraindicated based on severity of illness, there has been a lack of treatment options. This review describes a brief history of treatment guidelines for persistent air leaks. In the past 20 years, newer and less invasive treatment options have been developed...
March 3, 2017: Chest
https://www.readbyqxmd.com/read/28260878/effect-of-simvastatin-on-mmps-and-timps-in-cigarette-smoke-induced-rat-copd-model
#9
Jiawei Sun, Jie Bao, Yanan Shi, Bin Zhang, Lindong Yuan, Junhong Li, Lihai Zhang, Mo Sun, Ling Zhang, Wuzhuang Sun
BACKGROUND: Proteases may play an important role in the development of chronic obstructive pulmonary disease and emphysema in response to cigarette smoke exposure (CSE). The current study was designed to investigate the expression of matrix metalloproteinase (MMP)-8, MMP-9, MMP-12, tissue inhibitor of MMP (TIMP)-1, and TIMP-4 in rat lung tissues in response to CSE, and assessed the effect of simvastatin in regulating expression of MMPs and TIMPs. METHODS: Thirty normal Sprague Dawley (SD) rats were divided into control (n=10), CSE (n=10), and CSE plus simvastatin (n=10) groups...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28245136/reduced-frizzled-receptor-4-expression-prevents-wnt-%C3%AE-catenin-driven-alveolar-lung-repair-in-copd
#10
Wioletta Skronska-Wasek, Kathrin Mutze, Hoeke A Baarsma, Ken R Bracke, Hani N Alsafadi, Mareike Lehmann, Rita Costa, Mariano Stornaiuolo, Ettore Novellino, Guy G Brusselle, Darcy E Wagner, Ali Ö Yildirim, Melanie Königshoff
RATIONALE: Chronic obstructive pulmonary disease (COPD), in particular emphysema, is characterized by loss of parenchymal alveolar tissue and impaired tissue repair. WNT/β-catenin signaling is reduced in COPD, however, the mechanisms thereof, specifically the role of WNT receptors Frizzled (FZD), remains unexplored. OBJECTIVE: To identify and functionally characterize specific FZD receptors that control downstream WNT signaling in impaired lung repair in COPD. METHODS: FZD receptor expression was analyzed in lung homogenates and primary alveolar epithelial type II (ATII) cells of never-smokers, smokers, and COPD patients, as well as two experimental emphysema models by qRT-PCR, immunoblotting, and immunofluorescence...
February 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28238561/magnetic-resonance-imaging-of-the-inferior-alveolar-nerve-with-special-regard-to-metal-artifact-reduction
#11
Monika Probst, Vivien Richter, Jochen Weitz, Jan Stefan Kirschke, Carl Ganter, Matthias Troeltzsch, Mathias Nittka, Carl-Peter Cornelius, Claus Zimmer, Florian Andreas Probst
PURPOSE: Magnetic resonance imaging (MRI) is an excellent imaging modality for displaying peripheral nerves. Since the knowledge about MRI of the inferior alveolar nerve (IAN) is limited, this pilot study aims to identify the prospects and limitations of MRI of the IAN, with special consideration of metal artifacts. MATERIALS AND METHODS: Initially, in vitro MRI of a dental implant was performed to establish an optimized protocol for metal artifact reduction using WARP sequences (a software package provided by Siemens Healthcare, Erlangen, Germany) including view angle tilting (VAT) and slice-encoding metal artifact correction (SEMAC) techniques...
January 25, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28237967/heterozygous-vangl2-looptail-mice-reveal-novel-roles-for-the-planar-cell-polarity-pathway-in-adult-lung-homeostasis-and-repair
#12
Thanushiyan Poobalasingam, Laura L Yates, Simone A Walker, Miguel Pereira, Nina Y Gross, Akmol Ali, Maria Kolatsi-Joannou, Marjo-Riitta Jarvelin, Juha Pekkanen, Eugenia Papakrivopoulou, David A Long, Mark Griffiths, Darcy Wagner, Melanie Königshoff, Matthew Hind, Cosetta Minelli, Clare M Lloyd, Charlotte H Dean
Lung diseases impose a huge economic and health burden worldwide. A key aspect of several adult lung diseases, such as Idiopathic pulmonary fibrosis (IPF) and Chronic Obstructive pulmonary Disease (COPD), including emphysema, is aberrant tissue repair, which leads to an accumulation of damage and impaired respiratory function. Currently, there are few effective treatments available for these diseases and their incidence is rising.The Planar Cell Polarity (PCP) pathway is critical for the embryonic development of many organs, including kidney and lung...
February 24, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28236507/cephalometric-comparison-of-early-and-late-secondary-bone-grafting-in-the-treatment-of-patients-suffering-from-unilateral-cleft-lip-and-palate
#13
Andrzej Brudnicki, Ewa Sawicka, Renata Brudnicka, Piotr Stanisław Fudalej
The study was based on a retrospective cephalometric assessment of 10-year-olds in order to evaluate the influence of early secondary bone grafting on craniofacial development in patients suffering from non-syndromic complete unilateral cleft lip and palate. The study consisted of 79 patients in the early and 67 patients in the late secondary bone grafting group. The mean age at alveolar bone grafting was 2.5 years (SD 0.03) in the first group and 9.8 years (SD 2.3) in the second group. The primary cleft repair of these 146 patients was always performed in accordance with the one-stage method...
January 25, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28223796/stromelysin-2-mmp-10-facilitates-clearance-and-moderates-inflammation-and-cell-death-following-lung-exposure-to-long-multiwalled-carbon-nanotubes
#14
Tyler C Vandivort, Timothy P Birkland, Talita P Domiciano, Somenath Mitra, Terrance J Kavanagh, William C Parks
Multiwalled carbon nanotubes (MWCNTs) are nanomaterials composed of multiple layers of graphene cylinders with unique properties that make them valuable for a number of industries. However, rising global production has led to concerns regarding potential occupational exposures to them as raw materials during handling. This is especially true for long MWCNT fibers, whose aspect ratio has been posited to initiate pathology similar to that of asbestos. Matrix metalloproteinases (MMPs) are a class of extracellular endopeptidases that control various processes related to tissue repair, inflammation, and more...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28199407/keratin14-mrna-expression-in-human-pneumocytes-during-quiescence-repair-and-disease
#15
Marco Confalonieri, Emanuele Buratti, Gabriele Grassi, Rossana Bussani, Marco Chilosi, Rossella Farra, Michela Abrami, Cristiana Stuani, Francesco Salton, Miriam Ficial, Paola Confalonieri, Lorenzo Zandonà, Maurizio Romano
The lung alveoli slowly self-renew pneumocytes, but their facultative regeneration capacity is rapidly efficient after an injury, so fibrosis infrequently occurs. We recently observed Keratin 14 (KRT14) expression during diffuse alveolar damage (DAD), but not in controls. We wonder if KRT14 may be a marker of pneumocyte transition from quiescence to regeneration. Quantitative PCR and Western blot analyses highlighted the presence of KRT14 (mRNA and protein) only in human lung samples with DAD or interstitial lung disease (ILD)...
2017: PloS One
https://www.readbyqxmd.com/read/28195497/incisor-and-molar-overjet-arch-contraction-and-molar-relationship-in-the-mixed-dentition-in-repaired-complete-unilateral-cleft-lip-and-palate-a-qualitative-and-quantitative-appraisal
#16
Suteeta Disthaporn, Sunjay Suri, Bruce Ross, Bryan Tompson, Diogenes Baena, David Fisher, Wendy Lou
OBJECTIVE: To compare the mixed dentition incisor and molar overjet, severity of contraction of the dental arch, and the sagittal molar relationship on the cleft side vs the noncleft side in children with repaired complete unilateral cleft of the lip and palate (UCLP). MATERIALS AND METHODS: Orthodontic records taken prior to orthodontic preparation for alveolar bone grafting were screened to select study casts from patients with nonsyndromic repaired complete UCLP who did not have mandibular skeletal or dental asymmetry...
February 14, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/28193481/epigenetic-and-transcriptomic-regulation-of-lung-repair-during-recovery-from-influenza-infection
#17
Derek A Pociask, Keven M Robinson, Kong Chen, Kevin J McHugh, Michelle E Clay, Grace T Huang, Panayiotis V Benos, Yvonne M W Janssen-Heininger, Jay K Kolls, Vikas Anathy, John F Alcorn
Seasonal and pandemic influenza is a cause of morbidity and mortality worldwide. Most people infected with influenza virus display mild-to-moderate disease phenotypes and recover within a few weeks. Influenza is known to cause persistent alveolitis in animal models; however, little is known about the molecular pathways involved in this phenotype. We challenged C57BL/6 mice with influenza A/PR/8/34 and examined lung pathologic processes and inflammation, as well as transcriptomic and epigenetic changes at 21 to 60 days after infection...
February 9, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28157203/hepatocyte-growth-factor-secreted-by-bone-marrow-stem-cell-reduce-er-stress-and-improves-repair-in-alveolar-epithelial-ii-cells
#18
Izabela Nita, Katrin Hostettler, Luca Tamo, Michaela Medová, Giuseppe Bombaci, Jun Zhong, Ramanjaneyulu Allam, Yitzhak Zimmer, Michael Roth, Thomas Geiser, Amiq Gazdhar
Idiopathic Pulmonary Fibrosis (IPF) is a progressive, irreversible lung disease with complex pathophysiology. Evidence of endoplasmic reticulum (ER) stress has been reported in alveolar epithelial cells (AEC) in IPF patients. Secreted mediators from bone marrow stem cells (BMSC-cm) have regenerative properties. In this study we investigate the beneficial effects of BMSC-cm on ER stress response in primary AEC and ER stressed A549 cells. We hypothesize that BMSC-cm reduces ER stress. Primary AEC isolated from IPF patients were treated with BMSC-cm...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28151947/lung-protection-by-inhalation-of-exogenous-solubilized-extracellular-matrix
#19
Jinglei Wu, Priya Ravikumar, Kytai T Nguyen, Connie C W Hsia, Yi Hong
Decellularized extracellular matrix (ECM) contains complex tissue-specific components that work in concert to promote tissue repair and constructive remodeling and has been used experimentally and clinically to accelerate epithelial wound repair, leading us to hypothesize that lung-derived ECM could mitigate acute lung injury. To explore the therapeutic potential of ECM for noninvasive delivery to the lung, we decellularized and solubilized porcine lung ECM, then characterized the composition, concentration, particle size and stability of the preparation...
2017: PloS One
https://www.readbyqxmd.com/read/28140667/incidence-of-palatal-fistula-at-time-of-secondary-alveolar-cleft-reconstruction
#20
Vikram A Shankar, Alison Snyder-Warwick, Gary B Skolnick, Albert S Woo, Kamlesh B Patel
OBJECTIVE:   We aim to establish consistent time points for evaluating palatal fistula incidence to standardize reporting practices and clarify prospective literature. DESIGN:   An institutional retrospective chart review was conducted on 76 patients with unilateral or bilateral complete cleft lip and palate who underwent secondary alveolar bone grafting between 2006 and 2015. MAIN OUTCOME MEASURES:   Early fistula incidence rates were reported prior to maxillary expansion, and late fistula rates were reported at the time of alveolar bone grafting...
January 31, 2017: Cleft Palate-craniofacial Journal
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