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Alveolar regeneration

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https://www.readbyqxmd.com/read/29457935/customized-titanium-lattice-structure-in-three-dimensional-alveolar-defect-an-initial-case-letter
#1
Marcus Seiler, Peer W Kaemmerer, Michael Peetz, Amely Gundula Hartmann
The aim of this initial case report was to provide a new protocol for the clinical application of a patient-specific titanium lattice structure (Yxoss CBR®, ReOSS, Filderstadt, Germany) for customized bone regeneration. To obtain a 3-dimensional reconstruction of a posterior mandible segment in a 61-year-old woman, a patient-specific titanium customized lattice structure was used. As graft material autogenous bone tissue mixed with xenogenic alloplastic material (Bio Oss®, Geistlich Pharma, Wolhusen, Switzerland) was obtained for reconstruction...
February 19, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29428403/the-sonic-hedgehog-signaling-pathway-regulates-inferior-alveolar-nerve-regeneration
#2
Yurie Yamada, Atsushi Ohazama, Takeyasu Maeda, Kenji Seo
Activation of Shh signaling is known to be observed following injury of the peripheral nerves such as the sciatic nerve. However, the precise role of Shh signaling during peripheral nerve regeneration is not fully understood. The inferior alveolar nerve (IAN) is most commonly injured during oral surgery. Unlike the sciatic nerve, the IAN is isolated from other craniofacial tissues, as it resides in a long bony canal within the mandible. The IAN is thus an excellent experimental model for investigating peripheral nerve regeneration...
February 8, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29411112/treatment-of-intrabony-defects-with-modified-perforated-membranes-in-aggressive-periodontitis-a-12-month-randomized-controlled-trial
#3
Bartłomiej Górski, Stanisław Jalowski, Renata Górska, Maciej Zaremba
OBJECTIVE: The aim of this study was to compare the clinical and radiographic efficacy of guided tissue regeneration with a modified perforated collagen membrane (MPM) or standard collagen membrane (CM) in the treatment of intrabony defects in patients with aggressive periodontitis (AgP). MATERIALS AND METHODS: Fifteen AgP patients were included in the study. Two single intrabony defects of at least 3 mm depth with ≥ 6 mm probing pocket depth (PPD) from each patient were randomly assigned to either xenogenic graft plus MPM (test group) or xenogenic graft plus CM (control group)...
February 6, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29410765/alternative-intraoral-donor-sites-to-the-chin-and-mandibular-body-ramus
#4
REVIEW
David Reininger, Carlos Cobo-Vázquez, Benjamin Rosenberg, Juan López-Quiles
Background: Provide a review of alternative intraoral donor sites to the chin and body-ramus of the mandible that bring fewer complications and that may be used to regenerate small and medium defects. Material and Methods: A review was conducted using the search engine PUBMED and looking manually into scientific journals. Results: From the 35 articles included, 6 corresponded to the coronoids, 3 corresponded to the zygomatic body, 5 corresponded to the anterior maxillary sinus wall, 3 corresponded to the zygomatic alveolar process, 2 corresponded to the incisive fossa, 2 corresponded to the anterior nasal spine, 2 corresponded to the palatal region, 5 corresponded to the tuberosity, and 7 corresponded to the palatal and mandibular tori...
December 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29401707/in-vivo-evaluation-of-3d-printed-polycaprolactone-scaffold-implantation-combined-with-%C3%AE-tcp-powder-for-alveolar-bone-augmentation-in-a-beagle-defect-model
#5
Su A Park, Hyo-Jung Lee, Keun-Suh Kim, Sang Jin Lee, Jung-Tae Lee, Sung-Yeol Kim, Na-Hee Chang, Shin-Young Park
Insufficient bone volume is one of the major challenges encountered by dentists after dental implant placement. This study aimed to evaluate the efficacy of a customized three-dimensional polycaprolactone (3D PCL) scaffold implant fabricated with a 3D bio-printing system to facilitate rapid alveolar bone regeneration. Saddle-type bone defects were surgically created on the healed site after extracting premolars from the mandibles of four beagle dogs. The defects were radiologically examined using computed tomography for designing a customized 3D PCL scaffold block to fit the defect site...
February 4, 2018: Materials
https://www.readbyqxmd.com/read/29388788/correction-of-large-oro-antral-communications-from-previously-failed-implant-treatment-reconstruction-of-hard-and-soft-tissues
#6
Paul S Petrungaro, Santiago Gonzalez, Carlos Villegas
As dental implants become more popular for the treatment of partial and total edentulism and treatment of "terminal dentitions," techniques for the management of the atrophic posterior maxillae continue to evolve. Although dental implants carry a high success rate long term, attention must be given to the growing numbers of revisions or retreatment of cases that have had previous dental implant treatment and/or advanced bone replacement procedures that, due to either poor patient compliance, iatrogenic error, or poor quality of the pre-existing alveolar and/or soft tissues, have led to large osseous defects, possibly with deficient soft-tissue volume...
February 2018: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/29386045/mesenchymal-stem-cell-based-therapy-for-radiation-induced-lung-injury
#7
REVIEW
Tiankai Xu, Yuyu Zhang, Pengyu Chang, Shouliang Gong, Lihong Shao, Lihua Dong
Since radiotherapy is widely used in managing thoracic tumors, physicians have begun to realize that radiation-induced lung injury (RILI) seriously limits the effects of radiotherapy. Unfortunately, there are still no effective methods for controlling RILI. Over the last few decades numerous studies have reported the beneficial effects of mesenchymal stem cells (MSCs) on tissue repair and regeneration. MSCs can not only differentiate into lung alveolar epithelial cells and secrete anti-inflammatory factors, but they also deliver some vehicles for gene therapy in repairing the injured lung, which provides new ideas for managing RILI...
January 31, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29378675/therapeutic-effects-of-telomerase-in-mice-with-pulmonary-fibrosis-induced-by-damage-to-the-lungs-and-short-telomeres
#8
Juan Manuel Povedano, Paula Martinez, Rosa Serrano, Águeda Tejera, Gonzalo Gómez-López, Maria Bobadilla, Juana Maria Flores, Fátima Bosch, Maria A Blasco
Pulmonary fibrosis is a fatal lung disease characterized by fibrotic foci and inflammatory infiltrates. Short telomeres can impair tissue regeneration and are found both in hereditary and sporadic cases. We show here that telomerase expression using AAV9 vectors shows therapeutic effects in a mouse model of pulmonary fibrosis owing to a low-dose bleomycin insult and short telomeres. AAV9 preferentially targets regenerative alveolar type II cells (ATII). AAV9-Tert-treated mice show improved lung function and lower inflammation and fibrosis at 1-3 weeks after viral treatment, and improvement or disappearance of the fibrosis at 8 weeks after treatment...
January 30, 2018: ELife
https://www.readbyqxmd.com/read/29351052/particulate-coral-hydroxyapatite-sheltered-by-titanium-mesh-for-localized-alveolar-rehabilitation-after-onlay-graft-failure-a-case-report
#9
Miao Zhou, Shuyi Li, Hendrik Terheyden, Shuaishuai Cao, Yuejuan Che, Yuanming Geng
Reconstruction of bone loss in the alveolar ridge has long been challenging. Autologous bone grafts are considered as the "golden standard", while little research has focused on how to repair pronounced alveolar bone defects after autologous bone graft failure. The aim of this study was to detail a method based on the titanium mesh technique coupled with particulate coral hydroxyapatite to solve the Onlay graft failure. With bone deficiency in the #11 and #24- #25 regions, we harvested two autologous bone blocks for reconstruction...
January 19, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29344809/regeneration-of-functional-alveoli-by-adult-human-sox9-airway-basal-cell-transplantation
#10
Qiwang Ma, Yu Ma, Xiaotian Dai, Tao Ren, Yingjie Fu, Wenbin Liu, Yufei Han, Yingchuan Wu, Yu Cheng, Ting Zhang, Wei Zuo
Irreversible destruction of bronchi and alveoli can lead to multiple incurable lung diseases. Identifying lung stem/progenitor cells with regenerative capacity and utilizing them to reconstruct functional tissue is one of the biggest hopes to reverse the damage and cure such diseases. Here we showed that a rare population of SOX9+ basal cells (BCs) located at airway epithelium rugae can regenerate adult human lung. Human SOX9+ BCs can be readily isolated by bronchoscopic brushing and indefinitely expanded in feeder-free condition...
January 17, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29333088/bone-regeneration-using-silk-hydroxyapatite-hybrid-composite-in-a-rat-alveolar-defect-model
#11
Kyung S Koh, Jong Woo Choi, Eun Jeong Park, Tae Suk Oh
Background: To overcome the limited source of autogenous bone in bone grafting, many efforts have been made to find bone substitutes. The use of hybrid composites of silk and hydroxyapatite to simulate natural bone tissue can overcome the softness and brittleness of the individual components. Methods: Critical-sized, 7 x 4 x 1.5 mm alveolar defects were created surgically in 36 Sprague-Dawley rats. Three treatment groups were tested: an empty defect group (group I), a silk fibrin scaffold group (group II), and a hydroxyapatite-conjugated silk fibrin scaffold group (group III)...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29327431/enhanced-bone-regeneration-and-visual-monitoring-via-super-paramagnetic-iron-oxide-nanoparticle-scaffold-in-rats
#12
Shuying Hu, Yi Zhou, Yantao Zhao, Yang Xu, Feimin Zhang, Ning Gu, Junqing Ma, Mark A Reynolds, Yang Xia, Hockin H K Xu
A main challenge for use of scaffolds in bone engineering involves non-invasive monitoring in vivo and enhanced bone regeneration. The tissue-repair effect of super-paramagnetic iron oxide nanoparticles (SPIONs) was demonstrated previously by our group. However, testing in vivo is needed to confirm in vitro results. Here, SPIONs loaded gelatin sponge (GS) was used as a scaffold (SPIONs-GS) and implanted in the incisor sockets of Sprague-Dawley rats. Incisor sockets filled with nothing and filled with GS served as controls...
January 12, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29311578/promoting-induced-pluripotent-stem-cell-driven-biomineralization-and-periodontal-regeneration-in-rats-with-maxillary-molar-defects-using-injectable-bmp-6-hydrogel
#13
Ke-Hung Chien, Yuh-Lih Chang, Mong-Lien Wang, Jen-Hua Chuang, Ya-Chi Yang, Ming-Cheng Tai, Chien-Ying Wang, Yung-Yang Liu, Hsin-Yang Li, Jiang-Torng Chen, Shou-Yen Kao, Hen-Li Chen, Wen-Liang Lo
Periodontal disease may cause considerable destruction of alveolar bone, periodontal ligaments (PDLs) and cementum and even lead to progressive oral dysfunction. Periodontal tissue regeneration is the ultimate goal of periodontal disease treatment to reconstruct both structures and functions. However, the regenerative efficiency is low, possibly due to the lack of a proper periodontal microenvironment. In this study, we applied an injectable and thermosensitive chitosan/gelatin/glycerol phosphate hydrogel to provide a 3D environment for transplanted stem cells and to enhance stem cell delivery and engraftment...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29303409/clinical-evaluation-of-a-new-synthetic-resorbable-dental-membrane-a-case-series-study
#14
Hélène Martin Thomé, David Bourdin, Nicolas Strube, Afchine Saffarzadeh, Jean-Francois Morlock, Guillaume Campard, Charles Evanno, Alain Hoornaert, Pierre Layrolle
For the regeneration of small osseous defects, dental membranes are commonly used in oral and maxillofacial surgery. A new synthetic resorbable membrane has recently demonstrated its biocompatibility and bone regeneration capacity in preclinical studies. This membrane is made of poly-D,L-lactic/glycolic acid 85/15 (PLGA), has a bi-layered structure with a dense film to prevent gingival epithelial cell invasion and a micro-fibrous layer to support osteogenic cells and bone healing. This membrane completely degrades by hydrolysis in 4 to 6 months without signs of inflammation...
January 5, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29299496/effects-of-human-adipose-derived-stem-cells-and-platelet-rich-plasma-on-healing-response-of-canine-alveolar-surgical-bone-defects
#15
Reihaneh Shafieian, Maryam Moghaddam Matin, Amin Rahpeyma, Alireza Fazel, Hamideh Salari Sedigh, Ariane Sadr Nabavi, Halimeh Hassanzadeh, Alireza Ebrahimzadeh-Bideskan
Background: Due to the known disadvantages of autologous bone grafting, tissue engineering approaches have become an attractive method for ridge augmentation in dentistry. To the best of our knowledge, this is the first study conducted to evaluate the potential therapeutic capacity of PRP-assisted hADSCs seeded on HA/TCP granules on regenerative healing response of canine alveolar surgical bone defects. This could offer a great advantage to alternative approaches of bone tissue healing-induced therapies at clinically chair-side procedures...
November 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29288504/cell-therapy-with-allogenic-canine-periodontal-ligament-derived-cells-in-periodontal-regeneration-of-critical-size-defects
#16
J Nuñez, N Sanchez, F Vignoletti, I Sanz-Martin, R Caffesse, S Santamaria, J A Garcia-Sanz, M Sanz
AIM: The objective of this in-vivo experimental study to evaluate the regenerative potential of a cell therapy combining allogenic periodontal ligament derived cells with in a xenogeneic bone substitute in a similar experimental model. METHODS: In 9 beagle dogs, critical-size 6 mm supra-alveolar periodontal defects were created around the PIII and PIV. The resulting supra-alveolar defects were randomly treated with either 1.4 x 106 allogenic canine periodontal ligament-derived cells seeded on de-proteinized bovine bone mineral with 10% collagen (DBBM-C) (test group), or DBBM-C without cells (control group)...
December 29, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29285337/management-of-the-exposure-of-a-dense-ptfe-d-ptfe-membrane-in-guided-bone-regeneration-gbr-a-case-report
#17
P Ghensi, W Stablum, E Bettio, M C Soldini, T R Tripi, C Soldini
Guided bone regeneration (GBR) is a well-established and generally predictable method for repairing alveolar ridge defects and preparing edentulous sites for implant placement. Standard GBR involves filling the space underneath a membrane with autogenous bone or a mixture composed of autogenous bone particles and allogeneic bone tissue or heterologous biomaterials. The use of a barrier membrane for GBR has sometimes been associated with complications, however - reportedly involving exposure, infection, and collapse - and the non-resorbable types of membrane seem to be involved more often than the resorbable solutions...
July 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29285182/effects-of-caszi-on-bronchopulmonary-development-of-neonatal-rats
#18
Liping Xu, Ruifang Tong, Xiangnan Li, Lihong Liang, Han Huang
The effect of CASZI on bronchopulmonary development in neonatal rats was investigated. Forty SD rats were randomly divided into the control group (n=20) and the experimental group (n=20) using a random number table. The experimental group was treated with hyperoxia to establish the bronchopulmonary dysplasia (BPD) model, while the control group received no treatment. At 14 days of experiment, rats in each group were treated, and lung tissues were taken for hematoxylin and eosin (H&E) staining. Radial alveolar count (RAC) and morphological changes in lung tissues were observed under a microscope, and the thickness of respiratory membrane was detected via IPP6 image...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29284960/assessment-of-regeneration-of-bone-in-the-extracted-third-molar-sockets-augmented-using-xenograft-collaplugtn-zimmer-in-comparison-with-the-normal-healing-on-the-contralateral-side
#19
Murugan Ranganathan, M Balaji, R Krishnaraj, Vivek Narayanan, Annamalai Thangavelu
Introduction: Alveolar bone resorption is a significant clinical problem. Bone loss in third molar region following extraction or surgical removal not only leads to periodontal problems in second molar region but also it may lead to some serious problems like increased incidence of angle fractures. In order to reduce the risks following third molar surgery, the socket should be augmented with bone grafts. In recent days guided tissue regeneration is the most accepted and successful technique followed many authors and its efficacy has been proved...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29284945/comparison-of-marginal-periosteal-pedicle-graft-and-bioactive-glass-with-platelet-rich-fibrin-and-bioactive-glass-in-the-treatment-of-intrabony-defects-a-clinicoradiographic-study
#20
M S Yasaswini, K V Prabhakara Rao, P Tanuja, Narendra Reddy Motakatla
Introduction and Objectives: The objective of the study was to compare clinically and radiographically the regenerative potential of marginal periosteal pedicle graft (MPPG) or platelet-rich fibrin (PRF) with a bioactive glass in the treatment of two- and three-wall intrabony defects. Methods: A total of 28 sites (bilateral or contralateral infrabony defects) from 14 patient were treated with MPPG (Experimental site A) and the other site was treated with PRF (Experimental site B)...
November 2017: Journal of Pharmacy & Bioallied Sciences
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