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Alveolar regeneration

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https://www.readbyqxmd.com/read/28327066/guided-tissue-regeneration-in-four-teeth-using-a-liquid-polymer-membrane
#1
Jennifer B Alterman, John F Huff
Periodontal disease is one of the most common diseases diagnosed in dogs and cats. Guided tissue regeneration (GTR) is a treatment alternative to extraction of strategically important teeth. The barrier membrane used in the GTR procedure is of key importance. The purpose of this case series was to evaluate a liquid polymer gel as a membrane for GTR. The polymer gel ( N-methyl-2-pyrrolidone and poly [DL-lactide]) combined with 8.5% doxycycline hyclate was used in place of a traditional membrane in 4 teeth. The teeth were re-examined 6 months postoperatively for radiographic evaluation...
September 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28299252/secondary-closure-of-alveolar-cleft-with-resorbable-collagen-membrane-and-a-combination-of-intraoral-autogenous-bone-graft-and-deproteinized-anorganic-bovine-bone
#2
Lobna Abdel Aziz Aly, Nelly Hammouda
OBJECTS: Secondary alveolar bone grafting is a method that enables an excellent oral rehabilitation of the patients having alveolar cleft. The aim of this work is to report the closure of the alveolar cleft with the use of harvested autogenous bone graft combined with deproteinized anorganic bovine bone (Bio-Oss) under local anesthesia. SETTINGS AND SAMPLE POPULATION: Nine patients with age range, 8-11 years were consulted for their unilateral alveolar cleft. MATERIALS AND METHODS: A combination of symphyseal bone and deproteinized bovine bone mineral (DBBM) was placed into the alveolar cleft defect...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28291861/bone-regeneration-using-adipose-derived-stem-cells-with-fibronectin-in-dehiscence-type-defects-associated-with-dental-implants-an-experimental-study-in-a-dog-model
#3
Maria Àngels Sánchez-Garcés, Joaquín Alvira-González, Claudia Müller Sánchez, Joan R Barbany Cairó, Manuel Reina Del Pozo, Cosme Gay-Escoda
PURPOSE: To determine the bone regeneration potential of a ceramic biomaterial coated with fibronectin and adipose-derived stem cells covered in three-wall critical-size defects associated with dental implants. MATERIALS AND METHODS: In a total of 18 dogs, four dehiscence-type and critical-size defects were created surgically in the edentulous alveolar ridge with the simultaneous placement of dental implants. Defects were randomly regenerated using biomaterials coated with particulate ß-tricalcium phosphate (β-TCP), β-TCP with fibronectin (Fn) (β-TCP-Fn), and β-TCP with a combination of Fn and autologous adipose-derived stem cells (ADSCs) (β-TCP-Fn-ADSCs), leaving one defect as the control...
March 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28286396/reconstruction-of-a-post-traumatic-anterior-maxillary-defect-by-transport-distraction-osteogenesis
#4
K Rajkumar, R S Neelakandan, Pradeep Devadoss, T K Bandyopadhyay
Rehabilitation of segmental defects of maxilla presents a reconstructive challenge to obtain an ideal osseous form and height with adequate soft tissue investment. Though variety of prosthetic and surgical reconstructive options like the use of vascularized and non vascularized bone grafts are available they produce less than optimal results. Bone transport distraction is a reliable procedure in various maxillofacial bony defect reconstruction techniques. We describe herein a technique of maxillary bone transport distraction using an indigenously designed, custom made trifocal transport distractor performed in a post traumatic avulsive defect of the anterior maxilla...
March 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28276147/implant-guided-supracrestal-alveolar-bone-growth-using-scaffolds-bmp-2-and-novel-scaffold-retaining-device
#5
Bo Wen, David Shafer, Peter Schleier, David Pendrys, Liisa Kuhn, Martin Freilich
OBJECTIVE: To evaluate the efficacy of various scaffold systems and a Ti scaffold-retaining device with and without non-glycosylated rhBMP-2 (BMP-2) for increasing the vertical alveolar bone growth in the intra-oral mini-pig model. METHODS: Forty-eight Straumann Bone Level implants with hydrophilic (SLActive) surfaces were partially embedded in mandibles of 12 adult mini-pigs with the shoulder of the implant located 3 mm above the bone crest. Twenty-four implants were placed in conjunction with BMP-2 (50 μg) incorporated within resorbable scaffolds...
March 9, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28250998/a-novel-procedure-for-the-immediate-reconstruction-of-severely-resorbed-alveolar-sockets-for-advanced-periodontal-disease
#6
Mario Aimetti, Valeria Manavella, Luca Cricenti, Federica Romano
Background. Several clinical techniques and a variety of biomaterials have been introduced over the years in an effort to overcome bone remodeling and resorption after tooth extraction. However, the predictability of these procedures in sockets with severely resorbed buccal/lingual plate due to periodontal disease is still unknown. Case Description. A patient with advanced periodontitis underwent extraction of upper right lateral and central incisors. The central incisor exhibited complete buccal bone plate loss and a 9 mm vertical bone deficiency on its palatal side...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28236425/efficacy-of-platelet-rich-fibrin-after-mandibular-third-molar-extraction-a-systematic-review-and-meta-analysis
#7
REVIEW
Faez Saleh Al-Hamed, Mohamed Abdel-Monem Tawfik, Ehab Abdelfadil, Mohammed A Q Al-Saleh
PURPOSE: To assess the effect of platelet-rich fibrin (PRF) on the healing process of the alveolar socket after surgical extraction of the mandibular third molars. MATERIALS AND METHODS: PubMed, the Cochrane Central Register of Controlled Trials, Scopus, and relevant journals were searched using a combination of specific keywords ("platelet-rich fibrin," "oral surgery," and "third molar"). The final search was conducted on November 2, 2015. Randomized controlled clinical trials, as well as controlled clinical trials, aimed at comparing the effect of PRF versus natural healing after extraction of mandibular third molars were included...
February 1, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28203006/-observation-of-bone-morphology-in-furcation-defects-of-mandibular-molars-using-cone-beam-computed-tomography
#8
J Zhu, X Y Ouyang
OBJECTIVE: To observe mesial-distal bone morphology in classes II and III furcation involvements (FI) of mandibular molars using cone beam computed tomography (CBCT), to develop a classification system of mesial-distal bone morphology of furcation defects and to observe the intrabony defects on CBCT images. METHODS: Based on the existing CBCT data, the mandibular molars with horizontal bone defects in furcation area were observed. One hundred and seventeen sites of 81 mandibular molars with class II or class III FIclassified on CBCT images were included...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28203000/-effect-of-molar-ligation-and-local-porphyromonas-gingivalis-inoculation-on-alveolar-bone-loss-in-the-mouse
#9
L Gao, X Q Yu, Y Cai
OBJECTIVE: To compare the extent and time course of alveolar bone loss and osteoclast activation in two murine models of periodontal disease: molar ligation and Porphyromonas gingivalis (P. gingivalis) oral inoculation. METHODS: A split-mouth design was applied to two groups of mice (C57BL6, 6-8 weeks old, n=24 in both groups), resulting in four treatment groups: (1) Control group: unligated upper right 2nd molars receiving CMC only, (2)Ligature group: ligation of a 9-0 suture around the upper left 2nd molar, (3) P...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28199407/keratin14-mrna-expression-in-human-pneumocytes-during-quiescence-repair-and-disease
#10
Marco Confalonieri, Emanuele Buratti, Gabriele Grassi, Rossana Bussani, Marco Chilosi, Rossella Farra, Michela Abrami, Cristiana Stuani, Francesco Salton, Miriam Ficial, Paola Confalonieri, Lorenzo Zandonà, Maurizio Romano
The lung alveoli slowly self-renew pneumocytes, but their facultative regeneration capacity is rapidly efficient after an injury, so fibrosis infrequently occurs. We recently observed Keratin 14 (KRT14) expression during diffuse alveolar damage (DAD), but not in controls. We wonder if KRT14 may be a marker of pneumocyte transition from quiescence to regeneration. Quantitative PCR and Western blot analyses highlighted the presence of KRT14 (mRNA and protein) only in human lung samples with DAD or interstitial lung disease (ILD)...
2017: PloS One
https://www.readbyqxmd.com/read/28191779/development-of-a-three-dimensional-bioengineering-technology-to-generate-lung-tissue-for-personalized-disease-modeling
#11
Dan C Wilkinson, Jackelyn A Alva-Ornelas, Jennifer M S Sucre, Preethi Vijayaraj, Abdo Durra, Wade Richardson, Steven J Jonas, Manash K Paul, Saravanan Karumbayaram, Bruce Dunn, Brigitte N Gomperts
Stem cell technologies, especially patient-specific, induced stem cell pluripotency and directed differentiation, hold great promise for changing the landscape of medical therapies. Proper exploitation of these methods may lead to personalized organ transplants, but to regenerate organs, it is necessary to develop methods for assembling differentiated cells into functional, organ-level tissues. The generation of three-dimensional human tissue models also holds potential for medical advances in disease modeling, as full organ functionality may not be necessary to recapitulate disease pathophysiology...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28183199/recombinant-human-keratinocyte-growth-factor-attenuates-apoptosis-in-elastase-induced-emphysematous-mice-lungs
#12
Sudhir Kotnala, Sumit Baghel, Deepali Verma, Amit Tyagi, Jai Prakash Muyal
Alveolar cell apoptosis is one of the potential factors involved in the pathogenesis of emphysema. Recently, exogenous recombinant human keratinocyte growth factor (rHuKGF) has been reported to induce the regeneration of gas exchange structures. Therefore, the rationale of the present study was to investigate the potential effect of rHuKGF in ameliorating tissue destruction in the emphysematous mice lungs. Four experimental groups (i.e. control-, emphysema-, therapy- and therapy control-group) were prepared...
January 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28154254/effects-of-simvastatin-on-alveolar-regeneration-and-its-relationship-to-exposure-in-mice-with-dexamethasone-induced-emphysema
#13
Shihomi Hirooka, Misaki Ueno, Satoko Fukuda, Atsushi Miyajima, Takashi Hirota
In the present study, the relationship between systemic exposure of simvastatin (SV) hydroxy acid (SV-acid), an active form of SV, and its alveolar regeneration rates was investigated using emphysema model mice created by postnatal treatment of dexamethasone. In a model with young animals, the mice were treated with SV for 10 d from postnatal day 42. Similar alveolar regeneration with a % mean linear intercept (Lm) recovery of 60 to 70% by histochemical observation was observed in mice after intraperitoneal administration at dose in the range of 4-100 µg/mouse...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28144783/development-of-the-lung
#14
REVIEW
Johannes C Schittny
To fulfill the task of gas exchange, the lung possesses a huge inner surface and a tree-like system of conducting airways ventilating the gas exchange area. During lung development, the conducting airways are formed first, followed by the formation and enlargement of the gas exchange area. The latter (alveolarization) continues until young adulthood. During organogenesis, the left and right lungs have their own anlage, an outpouching of the foregut. Each lung bud starts a repetitive process of outgrowth and branching (branching morphogenesis) that forms all of the future airways mainly during the pseudoglandular stage...
March 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28128898/tri-layered-nanocomposite-hydrogel-scaffold-for-the-concurrent-regeneration-of-cementum-periodontal-ligament-and-alveolar-bone
#15
S Sowmya, Ullas Mony, P Jayachandran, S Reshma, R Arun Kumar, H Arzate, Shantikumar V Nair, R Jayakumar
A tri-layered scaffolding approach is adopted for the complete and concurrent regeneration of hard tissues-cementum and alveolar bone-and soft tissue-the periodontal ligament (PDL)-at a periodontal defect site. The porous tri-layered nanocomposite hydrogel scaffold is composed of chitin-poly(lactic-co-glycolic acid) (PLGA)/nanobioactive glass ceramic (nBGC)/cementum protein 1 as the cementum layer, chitin-PLGA/fibroblast growth factor 2 as the PDL layer, and chitin-PLGA/nBGC/platelet-rich plasma derived growth factors as the alveolar bone layer...
January 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28110067/poly-glycerol-sebacate-elastomer-supports-bone-regeneration-by-its-mechanical-properties-being-closer-to-osteoid-tissue-rather-than-to-mature-bone
#16
S H Zaky, K W Lee, J Gao, A Jensen, K Verdelis, Y Wang, A J Almarza, C Sfeir
Mechanical load influences bone structure and mass. Arguing the importance of load-transduction, we investigated the mechanisms inducing bone formation using an elastomeric substrate. We characterized Poly (glycerol sebacate) (PGS) in-vitro for its mechanical properties, compatibility with osteoprogenitor cells regarding adhesion, proliferation, differentiation under compression versus static cultures and in-vivo for the regeneration of a rabbit ulna critical size defect. The load-transducing properties of PGS were compared in-vitro to a stiffer poly lactic-co- glycolic-acid (PLA/PGA) scaffold of similar porosity and interconnectivity...
January 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28104582/amniotic-fluid-derived-stem-cells-mixed-with-platelet-rich-plasma-for-restoration-of-rat-alveolar-bone-defect
#17
Minjiao Wang, Hongliang Li, Jiawen Si, Jiewen Dai, Jun Shi, Xudong Wang, Lihe Guo, Guofang Shen
Stem cells isolated from the amniotic fluid have been shown as a promising candidate for cell therapy and tissue engineering. However, the experimental and preclinical applications of amniotic fluid-derived stem cells (AFSCs) in the very field of maxillofacial bone tissue engineering are still limited. In this study, rat AFSCs were successfully harvested and characterized in vitro The rat AFSCs showed typical fibroblastoid morphology, stable proliferation activity and multi-differentiation potential. Flow-cytometry analysis demonstrated that these cells were positive for CD29, CD44, and CD90, while negative for hematopoietic markers such as CD34 and CD45...
January 18, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28093204/chin-symphysis-bone-allograft-and-platelet-rich-fibrin-is-the-combination-effective-in-repair-of-alveolar-cleft
#18
Bijan Movahedian Attar, Navid Naghdi, Milad Etemadi Sh, Mojdeh Mehdizadeh
PURPOSE: Secondary grafting of alveolar defects with iliac crest bone is a common treatment method in cleft patients. The aim of this study was to evaluate the effectiveness of the combination of symphysis bone, allograft, and platelet-rich fibrin in regeneration of alveolar defects compared with iliac bone graft. MATERIALS AND METHODS: In this randomized clinical trial, patients with unilateral alveolar defects were divided randomly into two categories. Group A comprised patients in whom the combination of chin symphysis bone plus allogeneic bone material plus leukocyte- and platelet-rich fibrin was considered for treatment...
December 26, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28087752/deficient-retinoid-driven-angiogenesis-may-contribute-to-failure-of-adult-human-lung-regeneration-in-emphysema
#19
John-Poul Ng-Blichfeldt, Joana Alçada, M Angeles Montero, Charlotte H Dean, Uta Griesenbach, Mark J Griffiths, Matthew Hind
BACKGROUND: Molecular pathways that regulate alveolar development and adult repair represent potential therapeutic targets for emphysema. Signalling via retinoic acid (RA), derived from vitamin A, is required for mammalian alveologenesis, and exogenous RA can induce alveolar regeneration in rodents. Little is known about RA signalling in the human lung and its potential role in lung disease. OBJECTIVES: To examine regulation of human alveolar epithelial and endothelial repair by RA, and characterise RA signalling in human emphysema...
January 13, 2017: Thorax
https://www.readbyqxmd.com/read/28081379/direct-gingival-fibroblast-osteoblast-transdifferentiation-via-epigenetics
#20
Y Cho, B Kim, H Bae, W Kim, J Baek, K Woo, G Lee, Y Seol, Y Lee, Y Ku, I Rhyu, H Ryoo
Alveolar bone resorption caused by trauma or periodontal diseases has represented a challenge for both dental clinicians and researchers. In this study, we evaluate the osteogenic potential of human gingival fibroblasts (HGFs) through a direct transdifferentiation from HGFs to functional osteoblasts via epigenetic modification and osteogenic signaling with bone morphogenetic protein 2 (BMP2) in vitro and in vivo. HGF treatment with 5-aza-2'-deoxycytidine (5-aza-dC) induced demethylation in the hypermethylated CpG islands of the osteogenic lineage marker genes RUNX2 and ALP, and subsequent BMP2 treatment successfully drove the fibroblasts to the osteoblasts' lineage...
January 1, 2017: Journal of Dental Research
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