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Alveolar regeneration

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https://www.readbyqxmd.com/read/29238373/guided-tissue-regeneration-and-platelet-rich-growth-factor-for-the-treatment-of-grade-ii-furcation-defects-a-randomized-double-blinded-clinical-trial-a-pilot-study
#1
Niloofar Jenabian, Sina Haghanifar, Hodis Ehsani, Ehsan Zahedi, Masumeh Haghpanah
Background: The treatment of furcation area defects remained as a challenging issue in periodontal treatments. Regeneration treatment of furcation defects is the most discussed periodontal treatment. Although not completely hopeless in prognosis, the presence of the furcation involvement significantly increases the chance of tooth loss. The current research was conductedeto compare theeadditive effect of combined guided tissue regeneration (GTR) and platelet-rich growth factor (PRGF) on the treatment of furcation bony defects...
November 2017: Dental Research Journal
https://www.readbyqxmd.com/read/29220373/can-nerve-regeneration-on-an-artificial-nerve-conduit-be-enhanced-by-ethanol-induced-cervical-sympathetic-ganglion-block
#2
Yoshiki Shionoya, Katsuhisa Sunada, Keiji Shigeno, Akira Nakada, Michitaka Honda, Tatsuo Nakamura
This study aimed to determine whether nerve regeneration by means of an artificial nerve conduit is promoted by ethanol-induced cervical sympathetic ganglion block (CSGB) in a canine model. This study involved two experiments-in part I, the authors examined the effect of CSGB by ethanol injection on long-term blood flow to the orofacial region; part II involved evaluation of the effect of CSGB by ethanol injection on inferior alveolar nerve (IAN) repair using polyglycolic acid-collagen tubes. In part I, seven Beagles were administered left CSGB by injection of 99...
2017: PloS One
https://www.readbyqxmd.com/read/29211309/statins-in-nonsurgical-and-surgical-periodontal-therapy-a-systematic-review-and-meta-analysis-of-preclinical-in-vivo-trials
#3
REVIEW
K Bertl, I Steiner, N Pandis, K Buhlin, B Klinge, A Stavropoulos
The cholesterol-lowering drugs, statins, possess anti-inflammatory, antimicrobial and pro-osteogenic properties, and thus have been tested as an adjunct to periodontal treatment. The present systematic review aimed to answer the following focused research question: What is the effect of local and/or systemic statin use on periodontal tissues in preclinical in vivo studies of experimentally induced periodontitis (EIP) and/or acute/chronified periodontal defect (ACP) models? A literature search (of Medline/PubMed, Embase/Ovid, CENTRAL/Ovid) using the following main eligibility criteria was performed: (i) English or German language; (ii) controlled preclinical in vivo trials; (iii) local and/or systemic statin use in EIP and/or ACP models; and (iv) quantitative evaluation of periodontal tissues (i...
December 6, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29208033/evaluating-the-oxysterol-combination-of-22-s-hydroxycholesterol-and-20-s-hydroxycholesterol-in-periodontal-regeneration-using-periodontal-ligament-stem-cells-and-alveolar-bone-healing-models
#4
Jin-Sun Lee, EunJi Kim, Seonggu Han, Kyung Lhi Kang, Jung Sun Heo
BACKGROUND: Oxysterols, oxygenated by-products of cholesterol biosynthesis, play roles in various physiological and pathological systems. However, the effects of oxysterols on periodontal regeneration are unknown. This study investigated the effects of the specific oxysterol combination of 22(S)-hydroxycholesterol and 20(S)-hydroxycholesterol (SS) on the regeneration of periodontal tissues using in-vitro periodontal ligament stem cells (PDLSCs) and in-vivo models of alveolar bone defect...
December 6, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29195233/therapeutic-effect-of-bone-marrow-mesenchymal-stem-cells-pretreated-with-acetylsalicylic-acid-on-experimental-periodontitis-in-rats
#5
Yixin Zhang, Yi Xiong, Xiwen Chen, Chenfeng Chen, Zhimin Zhu, Lei Li
Periodontitis is a local inflammatory environment with dysregulation of host responses, which results in destruction of periodontal tissues. Mesenchymal stem cells (MSCs) have been proven to play important roles in tissue regeneration by serving as progenitor cells, but its therapeutic outcomes are yet, evaluated variable and unpredictable because of the influence of local inflammation. Acetylsalicylic acid (ASA) has been reported to benefit for MSCs in terms of inflammation control and tissue regeneration...
November 28, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29159853/the-use-of-cell-conditioned-medium-for-musculoskeletal-tissue-regeneration
#6
REVIEW
Francesca Veronesi, Veronica Borsari, Maria Sartori, Monia Orciani, Monica Mattioli-Belmonte Cima, Milena Fini
Tissue regenerative medicine combines the use of cells, scaffolds and molecules to repair damaged tissues. Different cell types are employed for musculoskeletal diseases, both differentiated and mesenchymal stromal cells (MSCs). In recent years, the hypothesis that cell-based therapy is guided principally by cell-secreted factors has become increasingly popular. The aim of the present literature review was to evaluate preclinical and clinical studies that used conditioned medium (CM), rich in cell-factors, for musculoskeletal regeneration with a cell-free approach...
November 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29154676/effects-of-bone-regeneration-materials-and-tooth-movement-timing-on-canine-experimental-orthodontic-treatment
#7
Ferdinand Mabula Machibya, Yiyuan Zhuang, Weizhong Guo, Dongdong You, Shan Lin, Dong Wu, Jiang Chen
OBJECTIVES: To evaluate the effects of bone regeneration materials and orthodontic tooth movement (OTM) timing on tooth movement through alveolar bone defects treated with guided bone regeneration (GBR) utilizing xenografts (Bio-Oss) and alloplast (β-TCP). MATERIALS AND METHODS: Twenty-four standard alveolar bone defects in six male beagle dogs were treated by GBR using either Bio-Oss or β-TCP (experimental), whereas the control defects were left empty. The defects were further grouped into early or late subgroups, depending on OTM timing after GBR (ie 1 month or 2 months, respectively)...
November 20, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/29147489/the-effect-of-platelet-rich-plasma-on-human-mesenchymal-stem-cell-induced-bone-regeneration-of-canine-alveolar-defects-with-calcium-phosphate-based-scaffolds
#8
Reihaneh Shafieian, Maryam Moghaddam Matin, Amin Rahpeyma, Alireza Fazel, Hamideh Salari Sedigh, Ariane Sadr-Nabavi, Halimeh Hassanzadeh, Alireza Ebrahimzadeh-Bideskan
Objectives: Autologous bone transplantation known as the "gold standard" to reconstruction of osseous defects has known disadvantages. This study was designed to explore the effects of hydroxy-apatite/tricalcium-phosphate (HA/TCP) and platelet-rich plasma (PRP) on the osteogenesis ability of human adipose-derived mesenchymal stem cells (hAdMSCs) in vitro and in vivo. Materials and Methods: hAdMSCs were incubated with HA/TCP granules and/or PRP in vitro and then, cell proliferation and differentiation was assessed by MTT assay, AZR S staining and SEM examination...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29140389/influence-of-rhbmp-2-on-guided-bone-regeneration-for-placement-and-functional-loading-of-dental-implants-a-radiographic-and-histologic-study-in-dogs
#9
Heithem Ben Amara, Jung-Won Lee, Jung-Ju Kim, Yun-Mi Kang, Eun-Jung Kang, Ki-Tae Koo
PURPOSE: Evidence on the outcomes of functional loading placed in recombinant human bone morphogenetic protein 2 (rhBMP-2)/acellular collagen sponge (ACS)-induced bone is lacking. The aim of this study was to verify whether guided bone regeneration (GBR) with rhBMP-2/ACS enhances regeneration of missing bone and osseointegration of dental implants subject to functional loading. MATERIALS AND METHODS: Two bilateral standardized large saddle-type defects (≈10 × 10 × 6 mm) were surgically created in each mandible of seven beagle dogs 2 months after tooth extraction...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29120889/bone-resorption-during-submerged-healing-after-guided-bone-regeneration-a-prospective-case-series
#10
Yong Hur, Yumi Ogata, Douglas W Kim, Charles M Pham, Tae-Ho Yoon, Hirokazu Ogata
OBJECTIVE: The aim of this study was to evaluate bone resorption quantitatively during the healing period subsequent to ridge augmentation. MATERIALS AND METHODS: Sixteen patients requiring vertical ridge augmentation before implant placement were recruited in the study. The study used an allograft and nonresorbable membrane. A custom acrylic stent was used to measure changes in bone volume. Augmented bone was compared with remaining bone 6 months after guided bone regeneration (α = 0...
December 2017: Implant Dentistry
https://www.readbyqxmd.com/read/29111365/autologous-fat-tissue-grafting-improves-pulmonary-healing-after-laser-metastasectomy
#11
Simone Furia, Pierfrancesco Cadenelli, Francesca Andriani, Paolo Scanagatta, Leonardo Duranti, Andrea Spano, Carlotta Galeone, Luca Porcu, Ugo Pastorino
BACKGROUND: Extensive clinical experience has demonstrated the potential usefulness of autologous fat tissue (AFT) graft in tissue reconstruction, repair or regeneration. In the present study, we evaluated the feasibility and safety of AFT in the repair of surgically injured lung surface. METHODS: Eighty consecutive procedures of pulmonary metastasectomy by laser precision resection, were performed in 66 patients between March 2010 and December 2012. In the first 20 procedures, AFT graft was applied on the wounded pulmonary surface without closure of parenchymal surface...
October 16, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29105932/bioactive-treatments-in-bone-grafts-for-implant-based-rehabilitation-systematic-review-and-meta-analysis
#12
REVIEW
Wellington Luiz de Oliveira da Rosa, Tiago Machado da Silva, Adriana Fernandes da Silva, Evandro Piva
BACKGROUND: The use of bioactive proteins, such as rhBMP-2, may improve bone regeneration in oral and maxillofacial surgery. PURPOSE: Analyze the effect of using bioactive proteins for bone regeneration in implant-based rehabilitation. MATERIALS AND METHODS: Seven databases were screened. Only clinical trials that evaluated the use of heterologous sources of bioactive proteins for bone formation prior to implant-based rehabilitation were included...
November 6, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29079935/periodontal-regeneration-induced-by-porous-alpha-tricalcium-phosphate-with-immobilized-basic-fibroblast-growth-factor-in-a-canine-model-of-2-wall-periodontal-defects
#13
Kazuya Matsuse, Yoshiya Hashimoto, Sachiro Kakinoki, Tetsuji Yamaoka, Shosuke Morita
We evaluated the effect of porous alpha-tricalcium phosphate (α-TCP) with immobilized basic fibroblast growth factor (bFGF) on periodontal regeneration in a canine model of 2-wall periodontal defects. Identical bone defects were made in the canine mandible; six defects in each animal were filled with porous α-TCP with bFGF bound via heparin (bFGF group), and the remaining defects were filled with unmodified porous α-TCP (control group). Micro-computed tomography and histological evaluation were performed at 2, 4, and 8 weeks post-implantation...
October 27, 2017: Medical Molecular Morphology
https://www.readbyqxmd.com/read/29077687/autogenous-partial-bone-chip-grafting-on-the-exposed-inferior-alveolar-nerve-after-cystic-enucleation
#14
Mi Hyun Seo, Mi Young Eo, Yun Ju Cho, Soung Min Kim, Suk Keun Lee
This prospective study evaluated the clinical effectiveness of the new approach of partial autogenous bone chip grafts for the treatment of mandibular cystic lesions related to the inferior alveolar nerve (IAN). A total of 38 patients treated for mandibular cysts or benign tumors were included in this prospective study and subsequently divided into 3 groups depending on the bone grafting method used: cystic enucleation without a bone graft (group 1), partial bone chip graft covering the exposed IAN (group 2), and autogenous bone graft covering the entire defect (group 3)...
October 26, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29062005/bone-marrow-mononuclear-cells-combined-with-beta-tricalcium-phosphate-granules-for-alveolar-cleft-repair-a-12-month-clinical-study
#15
Fengzhou Du, Huanhuan Wu, Haidong Li, Lei Cai, Qian Wang, Xia Liu, Ran Xiao, Ningbei Yin, Yilin Cao
Alveolar cleft is the most common congenital bone defect. Autologous iliac crest bone graft (ICBG) is the most widely adopted procedure for alveolar cleft repair, but the condition is associated with door-site morbidities. For the first time, this study used bone marrow mononuclear cells (BMMNCs) combined with beta-tricalcium phosphate (β-TCP) granules to repair alveolar bone defect. The effectiveness of this technique was compared with autologous ICBG after 12 months of follow-up. The bone formation volume was quantitatively evaluated by three-dimensional computed tomography and computer aided engineering technology...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042721/clinical-and-radiographic-evaluation-of-citric-acid-based-nano-hydroxyapatite-composite-graft-in-the-regeneration-of-intrabony-defects-a-randomized-controlled-trial
#16
Chaurasia Priya Dayashankar, P C Deepika, Basavarajaiah Siddaramaiah
BACKGROUND: Conventional periodontal therapy with various bone grafts has limited scope and the results are not predictable. To improve their utility, the hybridization of bioceramics and biodegradable polymers has been widely adopted to reform the mechanical properties of bone grafts. One such biodegradable polymer is POC (Poly 1,8 octanediol). Secondly, citric acid is considered as the key material in bone mineralization, which is related to the overall stability, strength and fracture resistance of bone...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29024920/chitosan-hydroxyapatite-ha-hydroxypropylmethyl-cellulose-hpmc-spongy-scaffolds-synthesis-and-evaluation-as-potential-alveolar-bone-substitutes
#17
Haffsah Iqbal, Moazzam Ali, Rabia Zeeshan, Zeeshan Mutahir, Farasat Iqbal, Muhammad Azhar Hayat Nawaz, Lubna Shahzadi, Aqif Anwar Chaudhry, Muhammad Yar, Shifang Luan, Ather Farooq Khan, Ihtesham-Ur Rehman
Alveolar bone loss is associated with infections and its augmentation is a pre-requisite for the success of dental implants. In present study, we aim to develop and evaluate novel freeze dried doxycycline loaded chitosan (CS)/hydroxyapatite (HA) spongy scaffolds where hydroxypropylmethyl cellulose (HPMC) was added as a crosslinker. Scaffolds displayed compressive strength of 14MPa/cm(3) and 0.34 as elastic response. The interconnected pore diameter was 41-273μm, favorably provided the template supporting cells and transport...
October 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29020507/custom-repair-of-mandibular-bone-defects-with-3d-printed-bioceramic-scaffolds
#18
H Shao, M Sun, F Zhang, A Liu, Y He, J Fu, X Yang, H Wang, Z Gou
Implanting artificial biomaterial implants into alveolar bone defects with individual shape and appropriate mechanical strength is still a challenge. In this study, bioceramic scaffolds, which can precisely match the mandibular defects in macro and micro, were manufactured by the 3-dimensional (3D) printing technique according to the computed tomography (CT) image. To evaluate the stimulatory effect of the material substrate on bone tissue regeneration in situ in a rabbit mandibular alveolar bone defect model, implants made with the newly developed, mechanically strong ~10% Mg-substituted wollastonite (Ca90%Mg10%SiO3; CSi-Mg10) were fabricated, implanted into the bone defects, and compared with implants made with the typical Ca-phosphate and Ca-silicate porous bioceramics, such as β-tricalcium phosphate (TCP), wollastonite (CaSiO3; CSi), and bredigite (Bred)...
October 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29018818/the-mechanical-properties-and-biometrical-effect-of-3d-preformed-titanium-membrane-for-guided-bone-regeneration-on-alveolar-bone-defect
#19
So-Hyoun Lee, Jong-Hoon Moon, Chang-Mo Jeong, Eun-Bin Bae, Chung-Eun Park, Gye-Rok Jeon, Jin-Ju Lee, Young-Chan Jeon, Jung-Bo Huh
The purpose of this study is to evaluate the effect of three-dimensional preformed titanium membrane (3D-PFTM) to enhance mechanical properties and ability of bone regeneration on the peri-implant bone defect. 3D-PFTMs by new mechanically compressive molding technology and manually shaped- (MS-) PFTMs by hand manipulation were applied in artificial peri-implant bone defect model for static compressive load test and cyclic fatigue load test. In 12 implants installed in the mandibular of three beagle dogs, six 3D-PFTMs, and six collagen membranes (CM) randomly were applied to 2...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28980856/cryogel-scaffolds-from-patient-specific-3d-printed-molds-for-personalized-tissue-engineered-bone-regeneration-in-pediatric-cleft-craniofacial-defects
#20
Katherine R Hixon, Alexa M Melvin, Alexander Y Lin, Andrew F Hall, Scott A Sell
Bone defects are extremely common in children with cleft-craniofacial conditions, especially those with alveolar cleft defects and cranial defects. This study used patient-specific 3D-printed molds derived from computed tomography and cryogel scaffold fabrication as a proof of concept for the creation of site-specific implants for bone reconstruction. Cryogel scaffolds are unique tissue-engineered constructs formed at sub-zero temperatures. When thawed, the resulting structure is macroporous, sponge-like, and mechanically durable...
January 1, 2017: Journal of Biomaterials Applications
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