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Alveolar regeneration

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https://www.readbyqxmd.com/read/28538076/regeneration-of-cystic-bone-cavities-and-bone-defects-with-bioactive-glass-s53p4-in-the-upper-and-lower-jaws
#1
Patricia Stoor, Satu Apajalahti, Risto Kontio
Cysts and tumors are common lesions in the jaws. To be able to retain a good volume of the alveolar ridge during healing as well as strengthening the angle and body of the mandible and provide an instant improved support for adjacent teeth, reliable long-term bone regeneration is needed. The purpose of this prospective study was to promote bone regeneration by filling bony defects in the upper or lower jaw with granules of the bioactive glass S53P4 (BAG), which have osteostimulative and antimicrobial properties...
May 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28531913/methods-of-isolation-and-characterization-of-stem-cells-from-different-regions-of-oral-cavity-using-markers-a-systematic-review
#2
REVIEW
Kavarthapu Avinash, Sankari Malaippan, Jayakumar Nadathur Dooraiswamy
Background: Periodontitis is a destructive inflammatory disorder of the periodontium caused by the destruction of periodontal tissues namely the PDL, cementum, alveolar bone, and gingiva. Once these tissues are lost, the foremost goal of periodontal therapy is to regenerate the diseased tissues if possible to their original form, architecture, and function. Various regenerative procedures were employed and still a gap was found in achieving the goal. As stem cells are characterized by their ability to self-renew and differentiate to produce specialized cells, there could be a possibility of using them for regenerative therapy...
May 30, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/28530121/glucocorticoids-retain-bi-potent-fibroblast-progenitors-during-alveolar-septation-in-mice
#3
Stephen E McGowan, Diann M McCoy
Glucocorticoids have been widely used and exert pleiotropic effects on alveolar structure and function, but do not improve the long-term clinical outcomes for patients with bronchopulmonary dysplasia, emphysema, or interstitial lung diseases. Treatments which foster alveolar regeneration could substantially improve the long-term outcomes for such patients. One approach to alveolar regeneration is to stimulate and guide intrinsic alveolar progenitors along developmental pathways used during secondary septation...
May 21, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28521114/msc-ecm-cellular-complexes-induce-periodontal-tissue-regeneration
#4
M Takewaki, M Kajiya, K Takeda, S Sasaki, S Motoike, N Komatsu, S Matsuda, K Ouhara, N Mizuno, T Fujita, H Kurihara
Transplantation of mesenchymal stem cells (MSCs), which possess self-renewing properties and multipotency, into a periodontal defect is thought to be a useful option for periodontal tissue regeneration. However, developing more reliable and predictable implantation techniques is still needed. Recently, we generated clumps of an MSC/extracellular matrix (ECM) complex (C-MSC), which consisted of cells and self-produced ECM. C-MSCs can regulate their cellular functions in vitro and can be grafted into a defect site, without any artificial scaffold, to induce bone regeneration...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28506464/recruited-monocytes-and-type-2-immunity-promote-lung-regeneration-following-pneumonectomy
#5
Andrew J Lechner, Ian H Driver, Jinwoo Lee, Carmen M Conroy, Abigail Nagle, Richard M Locksley, Jason R Rock
To investigate the role of immune cells in lung regeneration, we used a unilateral pneumonectomy model that promotes the formation of new alveoli in the remaining lobes. Immunofluorescence and single-cell RNA sequencing found CD115+ and CCR2+ monocytes and M2-like macrophages accumulating in the lung during the peak of type 2 alveolar epithelial stem cell (AEC2) proliferation. Genetic loss of function in mice and adoptive transfer studies revealed that bone marrow-derived macrophages (BMDMs) traffic to the lung through a CCL2-CCR2 chemokine axis and are required for optimal lung regeneration, along with Il4ra-expressing leukocytes...
May 3, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28499808/high-contrast-high-resolution-imaging-of-posttraumatic-mandibular-nerve-by-3dac-propeller-magnetic-resonance-imaging-correlation-with-the-severity-of-sensory-disturbance
#6
Makoto Terumitsu, Hitoshi Matsuzawa, Kenji Seo, Masaki Watanabe, Shigenobu Kurata, Akiko Suda, Tsutomu Nakada
OBJECTIVE: Magnetic resonance neurography reveals abnormal morphologies of regenerated nerves and overgrown connective tissue in injured trigeminal nerves, suggesting neuroma formation. We hypothesized that such deformities and scar formation contribute to pain symptoms. STUDY DESIGN: High-contrast high-resolution magnetic resonance imaging was utilized to evaluate the inferior alveolar nerve and lingual nerve following traumatic injury in 19 patients. The relationship between the morphologic classification and severity of the sensory disorder was assessed...
March 14, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28466249/mechanical-and-degradation-properties-of-advanced-platelet-rich-fibrin-a-prf-concentrated-growth-factors-cgf-and-platelet-poor-plasma-derived-fibrin-pptf
#7
Kazushige Isobe, Taisuke Watanebe, Hideo Kawabata, Yutaka Kitamura, Toshimitsu Okudera, Hajime Okudera, Kohya Uematsu, Kazuhiro Okuda, Koh Nakata, Takaaki Tanaka, Tomoyuki Kawase
BACKGROUND: Fibrin clot membranes prepared from advanced platelet-rich fibrin (A-PRF) or concentrated growth factors (CGF), despite their relatively rapid biodegradability, have been used as bioactive barrier membranes for alveolar bone tissue regeneration. As the membranes degrade, it is thought that the growth factors are gradually released. However, the mechanical and degradable properties of these membranes have not well been characterized. The purpose of this study was to mechanically and chemically characterize these membranes...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28462179/use-of-platelet-rich-plasma-in-the-management-of-periodontal-intra-osseous-defects-a-clinical-study
#8
Md Jalaluddin, Dhirendra K Singh, Ipsita Jayanti, Prasad Kulkarni, Mohamed Faizuddin, Fouzia Tarannum
BACKGROUND: Periodontal disease is characterized by the presence of gingival inflammation, periodontal pocket formation, loss of connective tissue attachment, and alveolar bone around the affected tooth. Alveolar bone support and attachment apparatus regeneration has been achieved through various processes and have given elusive results. An expedient and cost-effective approach to obtain autologous platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-β is the use of platelet-rich plasma (PRP)...
March 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28454301/immunohistochemical-profile-of-ing3-protein-in-normal-and-cancerous-tissues
#9
Wen-Feng Gou, Xue-Feng Yang, Dao-Fu Shen, Shuang Zhao, Hong-Zhi Sun, Jun-Sheng Luo, Hua-Chuan Zheng
The inhibitor of growth family, member 3 (ING3) protein may be capable of blocking the cell cycle via activating p53-transactivated promoters of p21 and Bcl2-associated X protein, and may induce apoptosis via a Fas/caspase-8-dependent signaling pathway. In the present study, immunohistochemistry was performed in order to characterize the expression profile of ING3 protein in tissue microarrays containing mouse and human normal tissue, human hepatocellular (n=62), renal clear cell (n=62), pancreatic (n=62), esophageal squamous cell (n=45), cervical squamous cell (n=31), breast (n=144), gastric (n=196), colorectal (n=96), ovarian (n=208), endometrial (n=96) and lung carcinoma (n=192)...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28445371/preventing-early-stage-graft-bone-resorption-by-simultaneous-innervation-innervated-iliac-bone-flap-for-mandibular-reconstruction
#10
Lei Wang, Jian-Hua Wei, Xi Yang, Zi-Hui Yang, Mo-Yi Sun, Xiao-Bing Cheng, Li-Qun Xu, De-Lin Lei, Chen-Ping Zhang
BACKGROUND: Postoperative resorption of vascularized bone grafts jeopardizes the success of dental implant(s) and functional rehabilitation of the jaw. Recent evidence supports the crucial role of innervation in bone regeneration and turnover. METHODS: This study reports a new technique for simultaneous innervation of vascularized iliac flaps in mandibular reconstruction, through neurorrhaphy between ilioinguinal nerves, which innervate iliac bone, and inferior alveolar nerves or great auricular nerves...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28441338/effects-of-3d-printed-polycaprolactone-%C3%AE-tricalcium-phosphate-membranes-on-guided-bone-regeneration
#11
Jin-Hyung Shim, Joo-Yun Won, Jung-Hyung Park, Ji-Hyeon Bae, Geunseon Ahn, Chang-Hwan Kim, Dong-Hyuk Lim, Dong-Woo Cho, Won-Soo Yun, Eun-Bin Bae, Chang-Mo Jeong, Jung-Bo Huh
This study was conducted to compare 3D-printed polycaprolactone (PCL) and polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) membranes with a conventional commercial collagen membrane in terms of their abilities to facilitate guided bone regeneration (GBR). Fabricated membranes were tested for dry and wet mechanical properties. Fibroblasts and preosteoblasts were seeded into the membranes and rates and patterns of proliferation were analyzed using a kit-8 assay and by scanning electron microscopy. Osteogenic differentiation was verified by alizarin red S and alkaline phosphatase (ALP) staining...
April 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28438860/bone-regeneration-of-hydroxyapatite-with-granular-form-or-porous-scaffold-in-canine-alveolar-sockets
#12
Seok Jin Jang, Se Eun Kim, Tae Sung Han, Jun Sik Son, Seong Soo Kang, Seok Hwa Choi
This study was undertaken to assess bone regeneration using hydroxyapatite (HA). The primary focus was comparison of bone regeneration between granular HA (gHA) forms and porous HA (pHA) scaffold. The extracted canine alveolar sockets were divided with three groups: control, gHA and pHA. Osteogenic effect in the gHA and pHA groups showed bone-specific surface and bone mineral density to be significantly higher than that of the control group (p<0.01). Bone volume fraction, bone mineral density, and amount of connective tissue related to disturbing osseointegration of the gHA group was higher than in the pHA group...
May 2017: In Vivo
https://www.readbyqxmd.com/read/28437177/periodontal-derived-mesenchymal-cell-sheets-promote-periodontal-regeneration-in-inflammatory-microenvironment
#13
Shujuan Guo, Jian Kang, Baohui Ji, Weihua Guo, Yi Ding, Yafei Wu, Weidong Tian
In this study, we investigated the periodontal regenerative potential of dental follicle cell (DFC) sheets and periodontal ligament cell (PDLC) sheets in the simulating inflammatory microenvironment of periodontitis, to confirm their regenerative potential for clinical application and explain the possible mechanism. The biological characteristics of DFC sheets and PDLC sheets were explored in lipopolysaccharide from Porphyromonas gingivalis (P. gingivalis LPS)-induced inflammation microenvironment in vitro, then cell sheets were transplanted into canine periodontal defects with experimental periodontitis in situ for 3 months...
May 18, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28432078/effect-of-4-5-6-7-8-tetrahydro-5-5-8-8-tetramethyl-2-naphthalenyl-carbamoyl-benzoic-acid-am80-on-alveolar-regeneration-in-adiponectin-deficient-mice-showing-a-chronic-obstructive-pulmonary-disease-like-pathophysiology
#14
Hitomi Sakai, Michiko Horiguchi, Tomomi Akita, Chihiro Ozawa, Mai Hirokawa, Yuki Oiso, Harumi Kumagai, Yoshito Takeda, Isao Tachibana, Norikazu Maeda, Chikamasa Yamashita
Chronic obstructive pulmonary disease (COPD) is an intractable pulmonary disease that causes widespread and irreversible alveolar collapse. Although COPD occurs worldwide, only symptomatic therapy is currently available. The objective of the present study was the development of therapeutic agents to eradicate COPD. Therefore, we focused on 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carbamoyl] benzoic acid (Am80), which is a derivative of all-trans retinoic acid. We evaluated the effects of Am80 on alveolar repair in a novel COPD model of adiponectin-deficient mice...
April 21, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28412609/dexamethasone-promotes-regeneration-of-crushed-inferior-alveolar-nerve-by-inhibiting-nf-%C3%AE%C2%BAb-activation-in-adult-rats
#15
Wei Gao, Dongdong Tong, Qing Li, Ping Huang, Fenghe Zhang
PURPOSE: Nuclear factor kappa B (NF-κB), which is closely related to inflammation, has become a topic of interest for research. The aim of this study is to investigate the effects of dexamethasone (Dex), an inhibitor of NF-κB, on inferior alveolar nerve injury in adult rats. MATERIALS AND METHODS: The crushed inferior alveolar model is established in Wistar rats and they are randomly divided into three groups according to treatment: pyrrolidine dithiocarbamate (PDTC), dexamethasone (Dex), and saline (physiological saline)...
April 6, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28401197/platelet-rich-fibrin-prf-in-implants-dentistry-in-combination-with-new-bone-regenerative-flapless-technique-evolution-of-the-technique-and-final-results
#16
Antonio Cortese, Giuseppe Pantaleo, Massimo Amato, Candace M Howard, Lorenzo Pedicini, Pier Paolo Claudio
Most common techniques for alveolar bone augmentation are guided bone regeneration (GBR) and autologous bone grafting. GBR studies demonstrated long-term reabsorption using heterologous bone graft. A general consensus has been achieved in implant surgery for a minimal amount of 2 mm of healthy bone around the implant. A current height loss of about 3-4 mm will result in proper deeper implant insertion when alveolar bone expansion is not planned because of the dome shape of the alveolar crest. To manage this situation a split crest technique has been proposed for alveolar bone expansion and the implants' insertion in one stage surgery...
January 2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/28394043/efficacy-of-stem-cells-on-periodontal-regeneration-systematic-review-of-pre-clinical-studies
#17
REVIEW
S A Tassi, N Z Sergio, M Y O Misawa, C C Villar
This systematic review aims to evaluate mesenchymal stem cells (MSC) periodontal regenerative potential in animal models. MEDLINE, EMBASE and LILACS databases were searched for quantitative pre-clinical controlled animal model studies that evaluated the effect of local administration of MSC on periodontal regeneration. The systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines. Twenty-two studies met the inclusion criteria. Periodontal defects were surgically created in all studies...
April 10, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28327066/guided-tissue-regeneration-in-four-teeth-using-a-liquid-polymer-membrane
#18
Jennifer B Alterman, John F Huff
Periodontal disease is one of the most common diseases diagnosed in dogs and cats. Guided tissue regeneration (GTR) is a treatment alternative to extraction of strategically important teeth. The barrier membrane used in the GTR procedure is of key importance. The purpose of this case series was to evaluate a liquid polymer gel as a membrane for GTR. The polymer gel ( N-methyl-2-pyrrolidone and poly [DL-lactide]) combined with 8.5% doxycycline hyclate was used in place of a traditional membrane in 4 teeth. The teeth were re-examined 6 months postoperatively for radiographic evaluation...
September 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28299252/secondary-closure-of-alveolar-cleft-with-resorbable-collagen-membrane-and-a-combination-of-intraoral-autogenous-bone-graft-and-deproteinized-anorganic-bovine-bone
#19
Lobna Abdel Aziz Aly, Nelly Hammouda
OBJECTS: Secondary alveolar bone grafting is a method that enables an excellent oral rehabilitation of the patients having alveolar cleft. The aim of this work is to report the closure of the alveolar cleft with the use of harvested autogenous bone graft combined with deproteinized anorganic bovine bone (Bio-Oss) under local anesthesia. SETTINGS AND SAMPLE POPULATION: Nine patients with age range, 8-11 years were consulted for their unilateral alveolar cleft. MATERIALS AND METHODS: A combination of symphyseal bone and deproteinized bovine bone mineral (DBBM) was placed into the alveolar cleft defect...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28291861/bone-regeneration-using-adipose-derived-stem-cells-with-fibronectin-in-dehiscence-type-defects-associated-with-dental-implants-an-experimental-study-in-a-dog-model
#20
Maria Àngels Sánchez-Garcés, Joaquín Alvira-González, Claudia Müller Sánchez, Joan R Barbany Cairó, Manuel Reina Del Pozo, Cosme Gay-Escoda
PURPOSE: To determine the bone regeneration potential of a ceramic biomaterial coated with fibronectin and adipose-derived stem cells covered in three-wall critical-size defects associated with dental implants. MATERIALS AND METHODS: In a total of 18 dogs, four dehiscence-type and critical-size defects were created surgically in the edentulous alveolar ridge with the simultaneous placement of dental implants. Defects were randomly regenerated using biomaterials coated with particulate ß-tricalcium phosphate (β-TCP), β-TCP with fibronectin (Fn) (β-TCP-Fn), and β-TCP with a combination of Fn and autologous adipose-derived stem cells (ADSCs) (β-TCP-Fn-ADSCs), leaving one defect as the control...
March 2017: International Journal of Oral & Maxillofacial Implants
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