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https://www.readbyqxmd.com/read/28795274/novel-gemcitabine-conjugated-albumin-nanoparticles-a-potential-strategy-to-enhance-drug-efficacy-in-pancreatic-cancer-treatment
#1
Varun Kushwah, Ashish Kumar Agrawal, Chander Parkash Dora, David Mallinson, Dimitrios A Lamprou, Ramesh C Gupta, Sanyog Jain
PURPOSE: The present study reports a novel conjugate of gemcitabine (GEM) with bovine serum albumin (BSA) and thereof nanoparticles (GEM-BSA NPs) to potentiate the therapeutic efficacy by altering physicochemical properties, improving cellular uptake and stability of GEM. METHODS: The synthesized GEM-BSA conjugate was extensively characterized by NMR, FTIR, MALDI-TOF and elemental analysis. Conjugation mediated changes in structural conformation and physicochemical properties were analysed by fluorescence, Raman and CD spectroscopy, DSC and contact angle analysis...
August 9, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28741097/distribution-and-phylogenetic-analysis-of-blastocystis-sp-subtypes-isolated-from-ibd-patients-and-healthy-individuals-in-iran
#2
H Mirjalali, M R Abbasi, N Naderi, Z Hasani, E S Mirsamadi, C R Stensvold, H Balaii, H Asadzadeh Aghdaei, M R Zali
Blastocystis is a single-celled intestinal parasite commonly found in humans and a broad range of animals all over the world. In humans, its role in health and disease remains unsettled. The aim of our study was to investigate the distribution of Blastocystis and Blastocystis subtypes (ST) in patients with inflammatory bowel disease (IBD) and control subjects. A total of 71 stool samples were collected from IBD patients, 69 and 2 of whom had ulcerative colitis (UC) and Crohn's Disease (CD), respectively. Moreover, 166 stool samples from healthy subjects were included as control samples...
July 25, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28551820/cd147-expression-in-peritoneal-injury
#3
Harald Seeger, Joerg Latus, Daniel Kitterer, M Dominik Alscher, Dagmar Biegger, Jin Chen, Ilka Edenhofer, Rudolf P Wüthrich, Stephan Segerer
BACKGROUND: Peritoneal injury is an important cause of technical failure of long-term peritoneal dialysis (PD). Encapsulating peritoneal sclerosis (EPS) is a severe complication of long-term PD with potentially life threatening consequences. CD147 is a glycoprotein with diverse functions including modulation of extracellular matrix via induction of matrix metalloproteinases, cell adhesion, and regulation of immune reactions. We hypothesized that CD 147 plays a role in the peritoneal cavity...
May 27, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28488587/expression-and-clinical-significance-of-cd147-in-renal-cell-carcinoma-a-meta-analysis
#4
Hui Li, Dongwen Wu, Shupeng Shi, Yadong Xu, Ling Wei, Jing Liu, Yanting Liu
OBJECTIVE: To assess clinical significance of CD147 in renal cell carcinoma. METHODS: Collect case-control studies which focus on CD147's expression in renal cell carcinoma. Trails were retrieved from CBM, CNKI, Wan-fang database, PubMed, Cochrane Library and Embase. According to the inclusion and exclusion criteria, data extraction and quality assessment were done by two researchers independently, and outcomes were pooled with Revman5.3 and STATA14.0. RESULTS: A total of 11 studies were confirmed, among which renal cell carcinoma 887 cases, non-cancer 505cases...
April 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28387059/pouch-excision-indications-and-outcomes
#5
Amy L Lightner, Sheev Dattani, Eric J Dozois, Sara B Moncrief, John H Pemberton, Kellie L Mathis
INTRODUCTION: Resotrative proctolectomy (RPC) with Ileal-pouch anal anastomosis (IPAA) is the procedure of choice for ulcerative colitis. Unfortunately, up to 10% of pouches will fail, requiring either reconstruction or excision. While several series have reported on the aetiology of pouch failure, no study to date has focused on the postoperative complications associated with pouch excision. METHODS: Patients who had excision of ileoanal reservoir with ileostomy (CPT code 45136) were included...
April 7, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28362144/long-term-effectiveness-of-vedolizumab-in-inflammatory-bowel-disease-a-national-study-based-on-the-swedish-national-quality-registry-for-inflammatory-bowel-disease-swibreg
#6
Carl Eriksson, Jan Marsal, Daniel Bergemalm, Lina Vigren, Jan Björk, Michael Eberhardson, Pontus Karling, Charlotte Söderman, Pär Myrelid, Yang Cao, Daniel Sjöberg, Mari Thörn, Per Karlén, Erik Hertervig, Hans Strid, Jonas F Ludvigsson, Sven Almer, Jonas Halfvarson
OBJECTIVES: Clinical trials have demonstrated the efficacy of vedolizumab in inflammatory bowel disease (IBD). However, these findings may not reflect the clinical practice. Therefore, we aimed to describe a vedolizumab-treated patient population and assess long-term effectiveness. MATERIALS AND METHODS: Patients initiating vedolizumab between 1 June 2014 and 30 May 2015 were identified through the Swedish National Quality Registry for IBD. Prospectively collected data on treatment and disease activity were extracted...
June 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28356976/cd147-promotes-the-proliferation-invasiveness-migration-and-angiogenesis-of-human-lung-carcinoma-cells
#7
Shaoxing Yang, Fei Qi, Chuanhao Tang, Hong Wang, Haifeng Qin, Xiaoyan Li, Jianjie Li, Weixia Wang, Changyun Zhao, Hongjun Gao
Cluster of differentiation (CD) 147 is a transmembrane glycoprotein that is highly expressed at the tumor cell surface, which stimulates fibroblasts to produce a large number of matrix metalloproteinases and promotes tumor invasion and metastasis and tumor-induced angiogenesis. The present study investigated the functions and the role of CD147 in the human lung carcinoma A549 cell line. The present study constructed expression and interference [small interfering (si) RNA] lentiviral vectors of CD147, which established stable overexpression and low expression of CD147 in the A549 cell line, named A549-CD147 and A549-siCD147, respectively...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28356935/melittin-inhibits-the-invasion-of-mcf-7-cells-by-downregulating-cd147-and-mmp-9-expression
#8
Jianjun Wang, Fengyu Li, Jiang Tan, Xuewei Peng, Lili Sun, Ping Wang, Shengnan Jia, Qingmiao Yu, Hongliang Huo, Hongyan Zhao
Tumor invasion and metastasis are the critical steps in determining the aggressive phenotype of human cancers. Melittin, a major component of bee venom, has been reported to induce apoptosis in several cancer cells. However, the mechanisms of melittin involvement in cancer invasion and metastasis remain unclear. Our previous study indicated that melittin inhibits cyclophilin A (CypA), a ubiquitously distributed peptidylprolyl cis-trans isomerase, in macrophage cells. In the present study, the Transwell assay results showed that melittin may downregulate the invasion level of MCF-7 cells in a dose-dependent manner...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28068760/laboratory-scale-microbial-food-chain-to-study-bioaccumulation-biomagnification-and-ecotoxicity-of-cadmium-telluride-quantum-dots
#9
Govind S Gupta, Ashutosh Kumar, Violet A Senapati, Alok K Pandey, Rishi Shanker, Alok Dhawan
The increasing applications of engineered nanomaterials (ENMs) in consumer products warrant a careful evaluation of their trophic transfer and consequent ecological impact. In the present study, a laboratory scale aquatic microbial food chain was established using bacteria (Escherichia coli (E. coli)) as a prey and ciliated protozoan (Paramecium caudatum) as a predator organism to determine the impact of cadmium telluride quantum dots (CdTe QDs). We observed that 29% of bacterivory potential of paramecium was lost, including an ∼12 h delay in doubling time on exposure to 25 mg/L CdTe QD (∼4 nm) as compared to control...
February 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27973793/envisaging-structural-insight-of-a-terminally-protected-proline-dipeptide-by-raman-spectroscopy-and-density-functional-theory-analyses
#10
Supriya Das, Uttam Pal, Moumita Chatterjee, Sumit Kumar Pramanik, Biswadip Banerji, Nakul C Maiti
The proline residue in a protein sequence generates constraints to its secondary structure as the associated torsion angles become a part of the heterocyclic ring. It becomes more significant when two consecutive proline residues link via amide linkage and produce additional configurational constraint to a protein's folding and stability. In the current manuscript we have illustrated conformation preference of a novel dipeptide, (R)-tert-butyl 2-((S)-2-(methoxycarbonyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate...
December 15, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27960359/noncompetitive-and-competitive-adsorption-of-heavy-metals-in-sulfur-functionalized-ordered-mesoporous-carbon
#11
Dipendu Saha, Soukaina Barakat, Scott E Van Bramer, Karl A Nelson, Dale K Hensley, Jihua Chen
In this work, sulfur-functionalized ordered mesoporous carbons were synthesized by activating the soft-templated mesoporous carbons with sulfur bearing salts that simultaneously enhanced the surface area and introduced sulfur functionalities onto the parent carbon surface. XPS analysis showed that sulfur content within the mesoporous carbons were between 8.2% and 12.9%. The sulfur functionalities include C-S, C═S, -COS, and SOx. SEM images confirmed the ordered mesoporosity within the material. The BET surface areas of the sulfur-functionalized ordered mesoporous carbons range from 837 to 2865 m(2)/g with total pore volume of 0...
December 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27893544/visceral-adiposity-genetic-susceptibility-and-risk-of-complications-among-individuals-with-crohn-s-disease
#12
Kimberley W J Van Der Sloot, Amit D Joshi, Danielle R Bellavance, Katherine K Gilpin, Kathleen O Stewart, Paul Lochhead, John J Garber, Cosmas Giallourakis, Vijay Yajnik, Ashwin N Ananthakrishnan, Behrooz Z Alizadeh, Ramnik J Xavier, Hamed Khalili
INTRODUCTION: Adipose tissue in mesenteric fat plays a key role in systemic and luminal inflammation. However, little is known about the role of visceral adipose tissue (VAT) and its interaction with genetic predisposition in Crohn's disease (CD) progression. METHODS: Our study population included patients with CD enrolled in Prospective Registry in Inflammatory Bowel Disease Study at Massachusetts General Hospital (PRISM). VAT volume was measured from computed tomography using Aquarius 3D...
January 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27885520/the-effect-of-pre-operative-topical-anaesthetic-cream-on-the-ablative-width-and-coagulative-depth-of-ablative-fractional-resurfacing-laser
#13
Preawphan Punyaratabandhu, Rungsima Wanitphakdeedecha, Penvadee Pattanaprichakul, Panitta Sitthinamsuwan, Weeranut Phothong, Sasima Eimpunth, Visnu Lohsiriwat, Woraphong Manuskiatti
Topical anaesthetic cream (TAC) is commonly used as a pre-treatment of ablative fractional resurfacing (AFR) laser. Most of anaesthetic cream contains distilled water as major component. Therefore, pre-operative TAC may interfere the photothermal reaction in the skin treated with fractional carbon-dioxide (FCO2) laser and fractional erbium-doped yttrium aluminium garnet (FEr:YAG) laser. The objective of the study was to compare the ablative width (AW) and coagulative depth (CD) of AFR laser with and without pre-treatment with TAC...
February 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/27823952/novel-findings-of-secreted-cyclophilin-a-in-diabetic-nephropathy-and-its-association-with-renal-protection-of-dipeptidyl-peptidase-4-inhibitor
#14
Shang-Feng Tsai, Chang-Chi Hsieh, Ming-Ju Wu, Cheng-Hsu Chen, Ting-Hui Lin, Mingli Hsieh
BACKGROUND: Our previous clinical indicated that urinary cyclophilin A was a good marker for diabetic nephropathy. METHODS: We used animal and cell models of diabetic nephropathy to examine the role of cyclophilin A in disease progression. RESULTS: Significantly increased urinary cyclophilin A could be detected in db/db at the 8th week. Linagliptin (3mg/kg/day and 15mg/kg/day) could suppress urinary 8-hydroxy-2'-deoxyguanosine at the 8th and 16th week but only the high dose Linagliption could suppress cyclophilin A at the 8th week...
December 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27773472/immunogenicity-of-live-attenuated-japanese-encephalitis-sa-14-14-2-vaccine-among-sri-lankan-children-with-previous-receipt-of-inactivated-je-vaccine
#15
Pushpa Ranjan Wijesinghe, M R Nihal Abeysinghe, Sutee Yoksan, Yafu Yao, Benli Zhou, Lei Zhang, Jessica A Fleming, Anthony A Marfin, John C Victor
BACKGROUND: The performance of live attenuated Japanese Encephalitis SA 14-14-2 vaccine (CD-JEV) among children previously given inactivated mouse brain-derived JE vaccine (IMBV) is unknown. We evaluated the safety and immunogenicity of CD-JEV administered to 2- and 5-year-old children in Sri Lanka. METHODS: In this open-label, single arm trial in the Colombo District of Sri Lanka, generally healthy children 2 and 5years of age who had previously received two and three doses of IMBV, respectively, were administered one dose of CD-JEV subcutaneously...
November 21, 2016: Vaccine
https://www.readbyqxmd.com/read/27761842/the-effects-of-cd147-on-the-cell-proliferation-apoptosis-invasion-and-angiogenesis-in-glioma
#16
Haoyuan Yin, Ying Shao, Xuan Chen
To analyze the effects of extracellular matrix metalloproteinase inducer (CD147) on glioma proliferation, apoptosis, invasion, and angiogenesis. Tissue samples were obtained from 101 glioma cases while normal brain tissues were obtained from 30 brain injury cases. Immunohistochemical assay was performed to detect the expressions of CD147, CD34, and VEGF in tissue samples. QRT-PCR was performed to detect the relative expression of CD147 mRNA in human glioma cell lines. CD147 siRNA was transfected into glioma cell line U251...
January 2017: Neurological Sciences
https://www.readbyqxmd.com/read/27612576/dose-response-gradients-between-a-composite-measure-of-six-risk-factors-and-cognitive-decline-and-cardiovascular-disease
#17
Mary L Adams, Joseph Grandpre
We created a composite risk factor index which includes 6 risk factors (diabetes, hypertension, obesity, depression, sedentary lifestyle, and current smoking) previously shown to be associated with cognitive decline (CD) and Alzheimer's disease (AD) as well as cardiovascular disease (CVD). Using 2011 Behavioral Risk Factor Surveillance System results for 95,147 adults ages ≥45years we found that 77.3% of study adults reported ≥1 risk factor (RF) while <1% reported all 6. Reporting any RFs increased risk for CD and CVD, with a dose-response gradient shown for increasing numbers of RFs from 0 to 6...
October 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27572002/association-between-morningness-and-resilience-in-korean-college-students
#18
So-Jin Lee, Chul-Soo Park, Bong-Jo Kim, Cheol-Soon Lee, Boseok Cha, Yu Jin Lee, Minah Soh, Jin Ah Park, Park So Young, Eun Hye Song
Circadian typology and sleep quality may be essential factors associated with the promotion of resilience. However, previous studies investigating the association between circadian typology and resilience did not analyze the effects of sleep quality on resilience. Thus, the present study evaluated the association between circadian typology and resilience in Korean college students after controlling for sleep quality. Additionally, this study investigated several sleep-related variables, including sleep duration, social jetlag and sunlight exposure during the daytime, to examine the modifiable behavioral features of morningness and also investigated whether the findings regarding morningness-related modifiable habits were associated with resilience...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27446405/cd147-modulates-androgen-receptor-activity-through-the-akt-gsk-3%C3%AE-%C3%AE-catenin-ar-pathway-in-prostate-cancer-cells
#19
Fang Fang, Yingxin Qin, Feng Hao, Qiang Li, Wei Zhang, Chen Zhao, Shuang Chen, Liangzhong Zhao, Liguo Wang, Jianhui Cai
The androgen signaling pathway serves an important role in the development of prostate cancer. β-Catenin is an androgen receptor (AR) cofactor and augments AR signaling. Glycogen synthase kinase-3β (GSK-3β), a target of phosphorylated serine/threonine protein kinase B (p-Akt), regulates β-catenin stability. In addition, β-catenin, a coregulator of AR, physically interacts with AR and enhances AR-mediated target gene transcription. The multifunctional glycoprotein cluster of differentiation (CD) 147 is highly expressed on the cell surface of the majority of cancer cells, and it promotes tumor invasion, metastasis and growth...
August 2016: Oncology Letters
https://www.readbyqxmd.com/read/27339637/circulating-bone-marrow-derived-cd45-cd34-cd133-vegf-endothelial-progenitor-cells-in-adults-with-crohn-s-disease
#20
Doron Boltin, Zvi Kamenetsky, Tsachi Tsadok Perets, Yifat Snir, Boris Sapoznikov, Hemda Schmilovitz-Weiss, Jacob Nadav Ablin, Ram Dickman, Yaron Niv
BACKGROUND: Circulating endothelial progenitor cells (EPCs) are bone marrow-derived stem cells able to migrate to sites of damaged endothelium and differentiate into endothelial cells. Altered EPC level and function have been described in various inflammatory diseases and have been shown to augment vasculogenesis in murine models. Previous studies of EPC in the context of Crohn's disease (CD) have yielded conflicting results. AIM: To determine whether the circulating levels of EPCs are changed in the context of CD...
March 2017: Digestive Diseases and Sciences
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