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https://www.readbyqxmd.com/read/27893544/visceral-adiposity-genetic-susceptibility-and-risk-of-complications-among-individuals-with-crohn-s-disease
#1
Kimberley W J Van Der Sloot, Amit D Joshi, Danielle R Bellavance, Katherine K Gilpin, Kathleen O Stewart, Paul Lochhead, John J Garber, Cosmas Giallourakis, Vijay Yajnik, Ashwin N Ananthakrishnan, Behrooz Z Alizadeh, Ramnik J Xavier, Hamed Khalili
INTRODUCTION: Adipose tissue in mesenteric fat plays a key role in systemic and luminal inflammation. However, little is known about the role of visceral adipose tissue (VAT) and its interaction with genetic predisposition in Crohn's disease (CD) progression. METHODS: Our study population included patients with CD enrolled in Prospective Registry in Inflammatory Bowel Disease Study at Massachusetts General Hospital (PRISM). VAT volume was measured from computed tomography using Aquarius 3D...
November 22, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27885520/the-effect-of-pre-operative-topical-anaesthetic-cream-on-the-ablative-width-and-coagulative-depth-of-ablative-fractional-resurfacing-laser
#2
Preawphan Punyaratabandhu, Rungsima Wanitphakdeedecha, Penvadee Pattanaprichakul, Panitta Sitthinamsuwan, Weeranut Phothong, Sasima Eimpunth, Visnu Lohsiriwat, Woraphong Manuskiatti
Topical anaesthetic cream (TAC) is commonly used as a pre-treatment of ablative fractional resurfacing (AFR) laser. Most of anaesthetic cream contains distilled water as major component. Therefore, pre-operative TAC may interfere the photothermal reaction in the skin treated with fractional carbon-dioxide (FCO2) laser and fractional erbium-doped yttrium aluminium garnet (FEr:YAG) laser. The objective of the study was to compare the ablative width (AW) and coagulative depth (CD) of AFR laser with and without pre-treatment with TAC...
November 24, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27823952/novel-findings-of-secreted-cyclophilin-a-in-diabetic-nephropathy-and-its-association-with-renal-protection-of-dipeptidyl-peptidase-4-inhibitor
#3
Shang-Feng Tsai, Chang-Chi Hsieh, Ming-Ju Wu, Cheng-Hsu Chen, Ting-Hui Lin, Mingli Hsieh
BACKGROUND: Our previous clinical indicated that urinary cyclophilin A was a good marker for diabetic nephropathy. METHODS: We used animal and cell models of diabetic nephropathy to examine the role of cyclophilin A in disease progression. RESULTS: Significantly increased urinary cyclophilin A could be detected in db/db at the 8th week. Linagliptin (3mg/kg/day and 15mg/kg/day) could suppress urinary 8-hydroxy-2'-deoxyguanosine at the 8th and 16th week but only the high dose Linagliption could suppress cyclophilin A at the 8th week...
December 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27773472/immunogenicity-of-live-attenuated-japanese-encephalitis-sa-14-14-2-vaccine-among-sri-lankan-children-with-previous-receipt-of-inactivated-je-vaccine
#4
Pushpa Ranjan Wijesinghe, M R Nihal Abeysinghe, Sutee Yoksan, Yafu Yao, Benli Zhou, Lei Zhang, Jessica A Fleming, Anthony A Marfin, John C Victor
BACKGROUND: The performance of live attenuated Japanese Encephalitis SA 14-14-2 vaccine (CD-JEV) among children previously given inactivated mouse brain-derived JE vaccine (IMBV) is unknown. We evaluated the safety and immunogenicity of CD-JEV administered to 2- and 5-year-old children in Sri Lanka. METHODS: In this open-label, single arm trial in the Colombo District of Sri Lanka, generally healthy children 2 and 5years of age who had previously received two and three doses of IMBV, respectively, were administered one dose of CD-JEV subcutaneously...
November 21, 2016: Vaccine
https://www.readbyqxmd.com/read/27761842/the-effects-of-cd147-on-the-cell-proliferation-apoptosis-invasion-and-angiogenesis-in-glioma
#5
Haoyuan Yin, Ying Shao, Xuan Chen
To analyze the effects of extracellular matrix metalloproteinase inducer (CD147) on glioma proliferation, apoptosis, invasion, and angiogenesis. Tissue samples were obtained from 101 glioma cases while normal brain tissues were obtained from 30 brain injury cases. Immunohistochemical assay was performed to detect the expressions of CD147, CD34, and VEGF in tissue samples. QRT-PCR was performed to detect the relative expression of CD147 mRNA in human glioma cell lines. CD147 siRNA was transfected into glioma cell line U251...
October 19, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27612576/dose-response-gradients-between-a-composite-measure-of-six-risk-factors-and-cognitive-decline-and-cardiovascular-disease
#6
Mary L Adams, Joseph Grandpre
We created a composite risk factor index which includes 6 risk factors (diabetes, hypertension, obesity, depression, sedentary lifestyle, and current smoking) previously shown to be associated with cognitive decline (CD) and Alzheimer's disease (AD) as well as cardiovascular disease (CVD). Using 2011 Behavioral Risk Factor Surveillance System results for 95,147 adults ages ≥45years we found that 77.3% of study adults reported ≥1 risk factor (RF) while <1% reported all 6. Reporting any RFs increased risk for CD and CVD, with a dose-response gradient shown for increasing numbers of RFs from 0 to 6...
October 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27572002/association-between-morningness-and-resilience-in-korean-college-students
#7
So-Jin Lee, Chul-Soo Park, Bong-Jo Kim, Cheol-Soon Lee, Boseok Cha, Yu Jin Lee, Minah Soh, Jin Ah Park, Park So Young, Eun Hye Song
Circadian typology and sleep quality may be essential factors associated with the promotion of resilience. However, previous studies investigating the association between circadian typology and resilience did not analyze the effects of sleep quality on resilience. Thus, the present study evaluated the association between circadian typology and resilience in Korean college students after controlling for sleep quality. Additionally, this study investigated several sleep-related variables, including sleep duration, social jetlag and sunlight exposure during the daytime, to examine the modifiable behavioral features of morningness and also investigated whether the findings regarding morningness-related modifiable habits were associated with resilience...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27446405/cd147-modulates-androgen-receptor-activity-through-the-akt-gsk-3%C3%AE-%C3%AE-catenin-ar-pathway-in-prostate-cancer-cells
#8
Fang Fang, Yingxin Qin, Feng Hao, Qiang Li, Wei Zhang, Chen Zhao, Shuang Chen, Liangzhong Zhao, Liguo Wang, Jianhui Cai
The androgen signaling pathway serves an important role in the development of prostate cancer. β-Catenin is an androgen receptor (AR) cofactor and augments AR signaling. Glycogen synthase kinase-3β (GSK-3β), a target of phosphorylated serine/threonine protein kinase B (p-Akt), regulates β-catenin stability. In addition, β-catenin, a coregulator of AR, physically interacts with AR and enhances AR-mediated target gene transcription. The multifunctional glycoprotein cluster of differentiation (CD) 147 is highly expressed on the cell surface of the majority of cancer cells, and it promotes tumor invasion, metastasis and growth...
August 2016: Oncology Letters
https://www.readbyqxmd.com/read/27339637/circulating-bone-marrow-derived-cd45-cd34-cd133-vegf-endothelial-progenitor-cells-in-adults-with-crohn-s-disease
#9
Doron Boltin, Zvi Kamenetsky, Tsachi Tsadok Perets, Yifat Snir, Boris Sapoznikov, Hemda Schmilovitz-Weiss, Jacob Nadav Ablin, Ram Dickman, Yaron Niv
BACKGROUND: Circulating endothelial progenitor cells (EPCs) are bone marrow-derived stem cells able to migrate to sites of damaged endothelium and differentiate into endothelial cells. Altered EPC level and function have been described in various inflammatory diseases and have been shown to augment vasculogenesis in murine models. Previous studies of EPC in the context of Crohn's disease (CD) have yielded conflicting results. AIM: To determine whether the circulating levels of EPCs are changed in the context of CD...
June 23, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27330558/correlates-of-conduct-disorder-among-inmates-of-a-nigerian-borstal-institution
#10
Anthony Ademola Olashore, Adegboyega Ogunwale, Timothy Olaolu Adebowale
BACKGROUND: Juvenile delinquency has become a significant global problem. Conduct disorder (CD), among other psychiatric disorders, has assumed prominence in its association with juvenile offending as well as criminality in adulthood. Despite this knowledge, little attention is given to this problem especially as it affects adjudicated adolescent offenders in developing countries. AIM: To examine the prevalence and correlates of CD among incarcerated adolescents in a Nigerian Borstal Institution and to investigate its independent predictors...
2016: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/27053056/long-term-impact-of-sewage-irrigation-on-soil-properties-and-assessing-risk-in-relation-to-transfer-of-metals-to-human-food-chain
#11
Ramu Meena, S P Datta, Debasis Golui, B S Dwivedi, M C Meena
A case study was undertaken to assess the risk of sewage-irrigated soils in relation to the transfer of trace elements to rice and wheat grain. For this purpose, peri-urban agricultural lands under the Keshopur Effluent Irrigation Scheme (KEIS) of Delhi were selected. These agricultural lands have been receiving irrigation through sewage effluents since 1979. Sewage effluent, groundwater, soil, and plant (rice and wheat grain) samples were collected with GPS coordinates from this peri-urban area. Under wheat crop, sewage irrigation for four decades resulted into a significant buildup of zinc (141 %), copper (219 %), iron (514 %), nickel (75...
July 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/26880133/association-of-extraintestinal-manifestations-and-anaemia-with-disease-outcomes-in-patients-with-inflammatory-bowel-disease
#12
Zsuzsanna Vegh, Zsuzsanna Kurti, Lorant Gonczi, Petra Anna Golovics, Barbara Dorottya Lovasz, Istvan Szita, Mihaly Balogh, Tunde Pandur, Stephan R Vavricka, Gerhard Rogler, Laszlo Lakatos, Peter Laszlo Lakatos
OBJECTIVE: The association between extraintestinal manifestations (EIMs) and disease activity suggest a common pathogenetic link with inflammatory bowel disease (IBD). We report on the association of EIMs and anaemia with long-term disease outcomes, including treatment steps, hospitalization, and surgery in the prospective population-based IBD inception cohort from Veszprem province. METHODS: Data of 678 incident IBD patients (Crohn's disease/ulcerative colitis(CD/UC): 331/347) diagnosed from 1st January 2000 to 31st December 2012 were analyzed (CD: m/f: 176/155, median age at diagnosis: 28, IQR: 21-40 years, disease duration: 6, IQR: 2-9 years; UC: m/f: 200/147, median age at diagnosis: 36, IQR: 26-50 years, duration: 7, IQR: 4-10 years)...
July 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/26827449/-cognitive-disorders-in-patients-with-traumatic-encephalopathy
#13
M N Matyash, L I Khudenko
As a result of examination 147, patients with traumatic encefalopatìû (TE) were explained the features of cognitive disorders, selected major psihopatologìcnì syndromes. The moderate cognitive disorders (KP) in patients THOSE, were observed in 40%bolnykh with the psikhorganicheskim syndrome, in 90.6% of patients with the asthenic syndrome, in 90.4%--by likvorodistsirkulyatornym syndrome and 76.1% in patients are cerebral--by focus syndrome. CD complicates, the progress of any post traumatic syndrome, in which they were presented...
April 2015: Likars'ka Sprava
https://www.readbyqxmd.com/read/26815198/long-term-evolution-and-predictive-factors-of-mild-inflammatory-bowel-disease
#14
C Reenaers, C Pirard, C Vankemseke, P Latour, J Belaiche, E Louis
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) are potentially progressive diseases. Few data are available on the prevalence and the factors associated with mild inflammatory bowel diseases (IBD). AIM: Our aim was to assess the natural history of mild CD and mild UC and to identify predictive factors of mild evolution over the long term. METHODS: Retrospective study of IBD patients registered in the database of the university hospital CHU of Liège, Belgium...
2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/26782265/ns-398-promotes-pancreatic-cancer-cell-invasion-by-cd147-and-mmp-2-via-the-activation-of-p38
#15
Hua Liu, Xuan-Fu Xu, Yan Zhao, Mao-Chun Tang, Ying-Qun Zhou, Feng-Hou Gao
The overexpression or abnormal activation of cyclo‑oxygenase‑2 (COX‑2) has been reported in pancreatic cancer cells. NS‑398, a selective inhibitor of COX‑2, is unable to inhibit pancreatic cancer cell proliferation, as determined by a Cell Counting Kit 8 assay. However, it does increase cancer cell invasiveness, and therefore the invasiveness of the PANC‑1 cells was determined, along with the activation of P38, which was assessed by western blotting. In the present study, to evaluate the mechanisms underlying the action of NS‑398 in pancreatic cancer cells, PANC‑1 cells were treated with NS‑398, and the invasion signaling pathways of cluster of differentiation (CD)147‑matrix metalloproteinase (MMP)‑2 and mitogen‑activated protein kinases were evaluated...
March 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26708648/isolation-of-hydrocarbon-degrading-and-biosurfactant-producing-bacteria-and-assessment-their-plant-growth-promoting-traits
#16
Magdalena Pacwa-Płociniczak, Tomasz Płociniczak, Joanna Iwan, Monika Żarska, Mirosław Chorążewski, Marzena Dzida, Zofia Piotrowska-Seget
Forty-two hydrocarbon-degrading bacterial strains were isolated from the soil heavily contaminated with petroleum hydrocarbons. Forty-one strains were identified based on their whole-cell fatty acid profiles using the MIDI-MIS method. Thirty-three of them belong to species Rhodococcus erythropolis, while the others to the genera Rahnella (4), Serratia (3) and Proteus (1). Isolates were screened for their ability to produce biosurfactants/bioemulsifiers. For all of them the activity of several mechanisms characteristic for plant growth-promoting bacteria was also determined...
March 1, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/26474889/synthesis-of-quercetin-loaded-nanoparticles-based-on-alginate-for-pb-ii-adsorption-in-aqueous-solution
#17
Yun Qi, Meng Jiang, Yuan-Lu Cui, Lin Zhao, Xia Zhou
Pb(II) is a representative heavy metal in industrial wastewater, which may frequently cause serious hazard to living organisms. In this study, comparative studies between alginate nanoparticles (AN) and quercetin-decorated alginate nanoparticles (Q-AN) were investigated for Pb(II) ion adsorption. Characterization of AN and Q-AN were analysed by transmission electron microscopy (TEM), Fourier transform infrared spectrometry (FT-IR), X-ray diffractometer (XRD), and thermogravimetric analysis (TG-DTG-DSC). The main operating conditions such as pH, initial concentration of Pb(II), and co-existing metal ions were also investigated using a batch experiment...
December 2015: Nanoscale Research Letters
https://www.readbyqxmd.com/read/26467806/heavy-metal-concentration-in-feathers-of-little-egret-egretta-garzetta-nestlings-in-three-coastal-breeding-colonies-in-spain
#18
Iratxe Rubio, Maite Martinez-Madrid, Leire Méndez-Fernández, Aitor Galarza, Pilar Rodriguez
The colonial ardeid Little Egret (Egretta garzetta), which is is protected under the European Birds Directive (2009/147/EC), can be a reliable bioindicator of aquatic environmental pollution. Concentrations of the heavy metals Cd, Cr, Cu, Hg, Ni, Pb and Zn in nestling feathers were assessed for three different breeding colonies of Little Egret on the Spanish coast during 2013 (5 individuals in Urdaibai, 10 in Santoña and 26 in Odiel). There were no significant differences in mean tissue residues of Cd, Ni, Pb and Zn between the colonies; however, mean concentration of Hg in Odiel nestlings was approximately three times lower than that of the other colonies, while Cr and Cu were significantly higher...
January 2016: Ecotoxicology
https://www.readbyqxmd.com/read/26378563/ecological-risk-of-heavy-metals-and-a-metalloid-in-agricultural-soils-in-tarkwa-ghana
#19
Nesta Bortey-Sam, Shouta M M Nakayama, Osei Akoto, Yoshinori Ikenaka, Elvis Baidoo, Hazuki Mizukawa, Mayumi Ishizuka
Heavy metals and a metalloid in agricultural soils in 19 communities in Tarkwa were analyzed to assess the potential ecological risk. A total of 147 soil samples were collected in June, 2012 and analyzed for As, Cd, Co, Cr, Cu, Hg, Ni, Pb and Zn. Mean concentrations (mg/kg dw) of heavy metals in the communities decreased in order of Zn (39) ˃ Cr (21) ˃ Pb (7.2) ˃ Cu (6.2) ˃ As (4.4) ˃ Ni (3.7) ˃ Co (1.8) ˃ Hg (0.32) ˃ Cd (0.050). Correlations among heavy metals and soil properties indicated that soil organic matter could have substantial influence on the total contents of these metals in soil...
September 2015: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/26376052/religious-coping-and-its-influence-on-psychological-distress-medication-adherence-and-quality-of-life-in-inflammatory-bowel-disease
#20
Thiago H Freitas, Thomas N Hyphantis, Elias Andreoulakis, João Quevedo, Hesley L Miranda, Gilberto S Alves, Marcellus H Souza, Lúcia L Braga, Kenneth I Pargament, Joanna K Soczynska, Roger S McIntyre, André F Carvalho
OBJECTIVE: Inflammatory bowel disease (IBD) is associated with elevated levels of anxiety and depression and a reduction in health-related quality of life (HRQoL). Nonadherence to treatment is also frequent in IBD and compromises outcomes. Religious coping plays a role in the adaptation to several chronic diseases. However, the influence of religious coping on IBD-related psychological distress, HRQoL, and treatment adherence remains unknown. METHOD: This cross-sectional study recruited 147 consecutive patients with either Crohn's disease or ulcerative colitis...
July 2015: Revista Brasileira de Psiquiatria
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