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Eleonora Horvath, Claudio F Silva, Sergio Majlis, Ignacio Rodriguez, Velimir Skoknic, Alex Castro, Hugo Rojas, Juan-Pablo Niedmann, Arturo Madrid, Felipe Capdeville, Carolina Whittle, Ricardo Rossi, Miguel Domínguez, Hernán Tala
OBJECTIVE: To assess performance of TIRADS classification on a prospective surgical cohort, demonstrating its clinical usefulness. METHODS: Between June 2009 and October 2012, patients assessed with pre-operative ultrasound (US) were included in this IRB-approved study. Nodules were categorised according to our previously described TIRADS classification. Final pathological diagnosis was obtained from the thyroidectomy specimen. Sensitivity, specificity, positive/negative predictive values and likelihood ratios were calculated...
October 7, 2016: European Radiology
Eun Ju Ha, Won-Jin Moon, Dong Gyu Na, Young Hen Lee, Nami Choi, Soo Jin Kim, Jae Kyun Kim
OBJECTIVE: To validate a new risk stratification system for thyroid nodules, the Korean Thyroid Imaging Reporting and Data System (K-TIRADS), using a prospective design. MATERIALS AND METHODS: From June 2013 to May 2015, 902 thyroid nodules were enrolled from four institutions. The type and predictive value of ultrasonography (US) predictors were analyzed according to the combination of the solidity and echogenicity of nodules; in addition, we determined malignancy risk and diagnostic performance for each category of K-TIRADS, and compared the efficacy of fine-needle aspiration (FNA) with a three-tier risk categorization system published in 2011...
September 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Vivian Y Park, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Jin Young Kwak
The majority of patients with papillary thyroid carcinoma (PTC) have an excellent prognosis, but some show poorer outcomes and would benefit from adjunctive prognostic tools. The B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutation, either based on both its presence or its quantitative measurement, and ultrasound (US) features may serve as a prognostic marker. The aim of this study was to investigate (1) the association between clinical-pathologic prognostic factors and the BRAF mutation found in fine-needle aspirates, based on both its presence and its corresponding cycle threshold (Ct) value, and (2) the association between prognostic factors and suspicious US features classified by the thyroid imaging reporting and data system (TIRADS) in PTC...
July 2016: Medicine (Baltimore)
Adnan R Zayadeen, Monzer Abu-Yousef, Kevin Berbaum
OBJECTIVE: The aim of this retrospective study was to develop a thyroid nodule scoring system for malignancy potential to better select nodules for ultrasound (US)-guided fine needle aspiration (FNA). MATERIALS AND METHODS: US-guided FNA was performed on 2375 thyroid nodules in successive patients. Cytologic or histopathologic confirmation of disease state in 2002 lesions showed that 148 were malignant. We developed an extended scoring system to provide more decision levels than standard scoring by including weak (macrocalcification, eggshell calcification, hypoechogenicity, solid consistency) as well as strong indicators of malignancy (microcalcification, hypoechogenicity, lobulated or ill-defined margins, taller-than-wide shape, suspicious lymph nodes) and by including contraindications (hyperechogenicity, comet-tail artifact, complete halo, cystic or microcystic)...
September 2016: AJR. American Journal of Roentgenology
Quan Tao, Yongming Zhou, Wenhui He
The prevalence of thyroid nodules in population is increasing around the world.To categorize thyroid nodules and stratify their malignant risk, thyroid imaging reporting and data system(TIRADS)was developed 6 years ago based on US , which is similar to breast imaging reporting and data system (BI-RADS). This paper aims at summarizing the particular content of kinds of TIRADS proposed by different researcher, clinic value of the application of TIRADS, the research status of TIRADS application, as well as the prospect of TIRADS based on CT and MRI...
May 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Hossein Gharib, Enrico Papini, Jeffrey R Garber, Daniel S Duick, R Mack Harrell, Laszlo Hegedüs, Ralf Paschke, Roberto Valcavi, Paolo Vitti
Thyroid nodules are detected in up to 50 to 60% of healthy subjects. Most nodules do not cause clinically significant symptoms, and as a result, the main challenge in their management is to rule out malignancy, with ultrasonography (US) and fine-needle aspiration (FNA) biopsy serving as diagnostic cornerstones. The key issues discussed in these guidelines are as follows: (1) US-based categorization of the malignancy risk and indications for US-guided FNA (henceforth, FNA), (2) cytologic classification of FNA samples, (3) the roles of immunocytochemistry and molecular testing applied to thyroid FNA, (4) therapeutic options, and (5) follow-up strategy...
May 2016: Endocrine Practice
Anuradha Chandramohan, Abhishek Khurana, B T Pushpa, Marie Therese Manipadam, Dukhabandhu Naik, Nihal Thomas, Deepak Abraham, Mazhuvanchary Jacob Paul
AIM: To assess the positive predictive value (PPV) and inter-observer agreement of Thyroid Imaging Reporting and Data System (TIRADS) as described by Kwak et al. MATERIALS AND METHODS: This was a prospective study wherein ultrasound was performed by two radiologists on patients with thyroid nodules >1 cm. The third radiologist interpreted archived images. Ultrasound features and TIRADS category were compared with cytology and surgical histopathology. PPV was calculated for all readers' combined assessment...
January 2016: Indian Journal of Radiology & Imaging
M Naren Satya Srinivas, V N Amogh, Munnangi Satya Gautam, Ivvala Sai Prathyusha, N R Vikram, M Kamala Retnam, B V Balakrishna, Narendranath Kudva
OBJECTIVES: To evaluate diagnostic reliability of the daily use of thyroid imaging reporting and data system (TIRADS) classification proposed by Kwak et al., in differentiating between a benign and a malignant thyroid lesion, to calculate inter-observer variability in the interpretation of each of the TIRADS ultrasound features and to evaluate role of TIRADS system in reducing unnecessary biopsies of benign lesions. MATERIALS AND METHODS: Three hundred and sixty-five patients with clinically suspected thyroid lesions during the period from November 1, 2011, to August 31, 2015, were prospectively scanned on gray-scale and Doppler imaging by six radiologists separately...
2016: Journal of Clinical Imaging Science
Jieun Koh, Eun-Kyung Kim, Jin Young Kwak, Jung Hyun Yoon, Hee Jung Moon
OBJECTIVES: To investigate whether repeat ultrasound-guided fine-needle aspiration (US-FNA) in initial atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) results could be performed 6 months after or more. METHODS: A total of 221 AUS/FLUS ≥10 mm with any follow-up were grouped according to the first follow-up interval at less than 6 months (group 1, n = 87) and 6 months or more (group 2, n = 134). Clinical features, final assessment of ultrasound (US) or the Thyroid Imaging Reporting and Data System (TIRADS), tumour size, extrathyroidal extension and lymph node metastasis in malignancies were compared...
March 10, 2016: European Radiology
Jung Hyun Yoon, Hyeong Ju Kwon, Eun-Kyung Kim, Hee Jung Moon, Jin Young Kwak
OBJECTIVE: To evaluate the clinical significance and compare the imaging features according to the Thyroid Image Reporting and Data System (TIRADS) between atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) subcategories. DESIGN & PATIENTS: A total of 192 thyroid nodules in 188 patients (mean age: 50·2 ± 11·8 years) that had been initially diagnosed as AUS/FLUS on US-guided fine needle aspiration (US-FNA) were included...
August 2016: Clinical Endocrinology
Vivian Youngjean Park, Eun-Kyung Kim, Jin Young Kwak, Jung Hyun Yoon, Min Jung Kim, Hee Jung Moon
The Thyroid Imaging Reporting and Data System (TIRADS) has been found to be accurate in the stratification of malignancy risk, and elastography has been found to have a high negative predictive value in non-diagnostic thyroid nodules. Through assessment of 104 solid non-diagnostic thyroid nodules, this study investigated the role of both in recommending repeat ultrasonography-guided fine-needle aspiration for solid thyroid nodules with non-diagnostic cytology. All nodules were classified by TIRADS (categories 4a, 4b, 4c and 5), and elastography scores were assigned according to the Rago and Asteria criteria...
February 2016: Ultrasound in Medicine & Biology
Yu-zhi Zhang, Ting Xu, Dai Cui, Xiao Li, Qing Yao, Hai-yan Gong, Xiao-yun Liu, Huan-huan Chen, Lin Jiang, Xin-hua Ye, Zhi-hong Zhang, Mei-ping Shen, Yu Duan, Tao Yang, Xiao-hong Wu
The thyroid imaging reporting and data system (TIRADS) and Bethesda system for reporting thyroid cytopathology (BSRTC) have been used for interpretation of ultrasound and fine-needle aspiration cytology (FNAC) results of thyroid nodules. BRAF(V600E) mutation analysis is a molecular tool in diagnosing thyroid carcinoma. Our objective was to compare the diagnostic value of these methods in differentiating high-risk thyroid nodules. Total 220 patients with high-risk thyroid nodules were recruited in this prospective study...
2015: Scientific Reports
Anna-Malika Camblats, Stéphanie Mathey
This study investigated whether and how the strength of reading interference in a colour categorization task can be influenced by lexical competition and the emotional characteristics of words not directly presented. Previous findings showed inhibitory effects of high-frequency orthographic and emotional neighbourhood in the lexical decision task. Here, we examined the effect of orthographic neighbour frequency according to the emotional valence of the higher-frequency neighbour in an emotional orthographic Stroop paradigm...
February 2016: Cognitive Processing
Jung Hyun Yoon, Hye Sun Lee, Eun-Kyung Kim, Hee Jung Moon, Jin Young Kwak
PURPOSE: To compare malignancy risk stratification of thyroid nodules with the 2014 American Thyroid Association (ATA) management guidelines and the Thyroid Imaging Reporting and Data System (TIRADS). MATERIALS AND METHODS: This retrospective study was approved by the institutional review board. The requirement to obtain informed consent was waived. From November 2013 to July 2014, 1293 thyroid nodules in 1241 patients (mean age, 50.8 years ± 13.5) were included in this study...
March 2016: Radiology
Su Yeon Ko, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Ha Yan Kim, Jin Young Kwak
OBJECTIVE: The aim of this study was to investigate and compare the diagnostic performances of the Thyroid Imaging Reporting and Data System (TIRADS) in differentiating benign and malignant thyroid nodules according to the level of physician experience. MATERIALS AND METHODS: From March to October 2013, 1102 patients with 1128 thyroid nodules who underwent initial ultrasound-guided fine needle aspiration were included in this study. Thyroid nodules were categorized according to TIRADS...
June 2016: Ultrasound Quarterly
Yu K Alexandrov, E D Sergeeva, A N Sencha
The ultrasonic signs or focal formations have a defining value for indication of fine-needle aspiration biopsy of thyroid nodules. The size and dynamics of growth aren't so important. The evaluation of indications for performing a thyroid nodules biopsy was made in 6403 patients. It was proved that the size of thyroid nodules hadn't any value for the indications and technique of aspiration biopsy. It was stated that a subjectivity assessment, many errors and parameters variety took place in clinical and ultrasound examination in the case of thyroid nodules changes...
2015: Vestnik Khirurgii Imeni I. I. Grekova
Jung Hyun Yoon, Arthur Cho, Hye Sun Lee, Eun-Kyung Kim, Hee Jung Moon, Jin Young Kwak
BACKGROUND: Our aim was to evaluate the role of the Thyroid Imaging Reporting and Data System (TIRADS) in the risk stratification of thyroid incidentalomas detected on (18)F-fluorodeoxyglucose-positron emission tomography/computed tomography ((18)F-FDG-PET/CT) scans. METHODS: Eighty-seven thyroid nodules in 84 patients showing incidentally detected increased uptake on (18)F-FDG-PET/CT who also had ultrasonography (US)-guided fine needle aspiration performed were included...
November 2015: Surgery
Simone Schenke, T Rink, M Zimny
AIM: To test the feasibility of the Thyroid Imaging Reporting And Data System (TIRADS) according to Horvath and Kwak for the assessment of thyroid nodules. PATIENTS, METHOD: Retrospective analysis of patients with thyroid nodules applying the following inclusion criteria: B-mode-ultrasound, surgery and histological results. Thyroid nodules were classified as TIRADS 2, 3, 4A, 4B, 4C, 5 and 6. RESULTS: A total of 172 patients were included (133 women, 48 ± 13 years, 39 men, 49 ± 11 years) with 222 thyroid nodules (24...
2015: Nuklearmedizin. Nuclear Medicine
Jung Hyun Yoon, Hye Sun Lee, Eun-Kyung Kim, Hee Jung Moon, Jin Young Kwak
PURPOSE: To compare the malignancy rates and the effectiveness of the Thyroid Imaging Reporting and Data System (TIRADS) for risk stratification of nodules with nondiagnostic results classified before and after application of the Bethesda System for Reporting Thyroid Cytopathology. MATERIALS AND METHODS: This retrospective study was approved by an institutional review board, with waiver of informed consent. A total of 763 patients with 790 thyroid nodules and nondiagnostic cytologic results were included (mean age ± standard deviation, 52...
August 2015: Radiology
Vivian Youngjean Park, Eun-Kyung Kim, Jin Young Kwak, Jung Hyun Yoon, Hee Jung Moon
PURPOSE: To evaluate the malignancy risk and characteristics of thyroid nodules with two "Atypia of Undetermined Significance" or "Follicular Lesion of Undetermined Significance" (AUS/FLUS) results, and compare characteristics of malignancies with two AUS/FLUS results to those with one AUS/FLUS result. METHODS: Of 441 thyroid nodules with initial AUS/FLUS results, 236 underwent repeat fine-needle-aspiration (FNA), with 58 obtaining repeated AUS/FLUS results. Thyroid Imaging Reporting and Data System (TIRADS) categories were assigned, and clinico-pathological characteristics were compared between benign and malignant nodules and between malignancies with two consecutive AUS/FLUS results and those with one AUS/FLUS result...
September 2015: European Radiology
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