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https://www.readbyqxmd.com/read/29346130/reply-management-of-descemet-membrane-detachment-after-forceps-birth-injury
#1
Jack S Parker, John S Parker, Gerrit R J Melles
No abstract text is available yet for this article.
January 17, 2018: Cornea
https://www.readbyqxmd.com/read/29345540/cost-effectiveness-analysis-of-asymptomatic-peripheral-artery-disease-screening-with-the-abi-test
#2
Nathan K Itoga, Hataka R Minami, Meenadachi Chelvakumar, Keon Pearson, Matthew M Mell, Eran Bendavid, Douglas K Owens
Screening for asymptomatic peripheral artery disease (aPAD) with the ankle-brachial index (ABI) test is hypothesized to reduce disease progression and cardiovascular (CV) events by identifying individuals who may benefit from early initiation of medical therapy. Using a Markov model, we evaluated the cost effectiveness of initiating medical therapy (e.g. statin and ACE-inhibitor) after a positive ankle-brachial index (ABI) screen in 65-year-old patients. We modeled progression to symptomatic PAD (sPAD) and CV events with and without ABI screening, evaluating differences in costs and quality-adjusted life years (QALYs)...
January 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29343529/quarter-descemet-membrane-endothelial-keratoplasty-quarter-dmek-for-fuchs-endothelial-corneal-dystrophy-6-months-clinical-outcome
#3
Vasiliki Zygoura, Lamis Baydoun, Lisanne Ham, Vincent J A Bourgonje, Korine van Dijk, Jessica T Lie, Isabel Dapena, Silke Oellerich, Gerrit R J Melles
BACKGROUND/AIM: To assess the clinical outcome of the first series of Quarter-Descemet membrane endothelial keratoplasty (Quarter-DMEK), a potential hybrid technique between 'descemetorhexis only' and conventional, circular DMEK. METHODS: Prospective interventional case series at a tertiary referral centre. Twelve eyes of 12 patients with central Fuchs endothelial corneal dystrophy underwent Quarter-DMEK, that is, transplantation of one quadrant of a full-diameter DMEK graft, and were evaluated for best-corrected visual acuity (BCVA), endothelial cell density (ECD) and complications up to 6 months postoperatively...
January 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29325868/canadian-genome-wide-association-study-and-meta-analysis-confirm-hla-as-a-risk-factor-for-peanut-allergy-independent-of-asthma
#4
Yuka Asai, Aida Eslami, C Dorien van Ginkel, Loubna Akhabir, Ming Wan, David Yin, George Ellis, Moshe Ben-Shoshan, Ingo Marenholz, David Martino, Manuel A Ferreira, Katrina Allen, Bruce Mazer, Hans de Groot, Nicolette W de Jong, Roy Gerth van Wijk, Anthony E J Dubois, Sarah Grosche, Sarah Ashley, Franz Rüschendorf, Birgit Kalb, Kirsten Beyer, Markus M Nöthen, Young-Ae Lee, Rick Chin, Steven Cheuk, Joshua Hoffman, Eric Jorgensen, John S Witte, Ronald B Melles, Xiumei Hong, Xiaobin Wang, Jennie Hui, Arthur W Bill Musk, Michael Hunter, Alan L James, Gerard H Koppelman, Andrew J Sandford, Ann E Clarke, Denise Daley
No abstract text is available yet for this article.
January 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29316874/liposomal-delivery-of-demineralised-dentine-matrix-for-dental-tissue-regeneration
#5
Genevieve Elizabeth Melling, John Colombo, Steven J Avery, Wayne Ayre, Samuel L Evans, Rachel Jane Waddington, Alastair James Sloan
Current dental restorations have short longevity, consequently there is a need for novel tissue engineering strategies that aim to regenerate the dentine-pulp complex. Dentine matrix contains a myriad of bioactive growth factors and extracellular matrix proteins associated with the recruitment, proliferation and differentiation of dental pulp progenitor cells. Here, we show that demineralised dentine matrix (DDM), from non-carious dentine, can be encapsulated into liposomes for delivery to dental tissue to promote regeneration...
January 9, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29300399/selective-g-quadruplex-binding-by-oligoarginine-ru-dppz-metallopeptides
#6
David Bouzada, Iria Salvadó, Ghofrane Barka, Gustavo Rama, José Martínez-Costas, Romina Lorca, Álvaro Somoza, Manuel Melle-Franco, M Eugenio Vázquez, Miguel Vázquez López
A set of Ru(ii) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding preference for DNA G-quadruplex structures over those lacking it, and also that the interplay between the octoarginine functionalization and the ancillary ligand in the complex has an essential role in the recognition process. Furthermore, the oligoarginine metallopeptides are also efficiently internalized, causing cell death with signs of apoptosis...
January 4, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29249592/robotic-low-anterior-resection-versus-transanal-total-mesorectal-excision-in-rectal-cancer-a-comparison-of-115-cases
#7
Daniel Perez, Nathaniel Melling, Matthias Biebl, Matthias Reeh, Julia-Kristin Baukloh, Jameel Miro, Adam Polonski, Jakob R Izbicki, Belinda Knoll, Johann Pratschke, Felix Aigner
BACKGROUND: Robotic low anterior resection (RLAR) and transanal total mesorectal excision (TaTME) are novel surgical techniques for resection of rectal cancer. To our knowledge, no data exist on direct comparison of these procedures in terms of oncological or functional parameters. METHODS: 60 RLAR and 55 TaTME for rectal cancer were compared in respect to patient characteristics, clinicopathological parameters, intraoperative and perioperative results and anatomopathological outcome...
November 26, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29243348/mental-healthcare-staff-well-being-and-burnout-a%C3%A2-narrative-review-of-trends-causes-implications-and-recommendations-for-future-interventions
#8
REVIEW
Judith Johnson, Louise H Hall, Kathryn Berzins, John Baker, Kathryn Melling, Carl Thompson
Rising levels of burnout and poor well-being in healthcare staff are an international concern for health systems. The need to improve well-being and reduce burnout has long been acknowledged, but few interventions target mental healthcare staff, and minimal improvements have been seen in services. This review aimed to examine the problem of burnout and well-being in mental healthcare staff and to present recommendations for future research and interventions. A discursive review was undertaken examining trends, causes, implications, and interventions in burnout and well-being in healthcare staff working in mental health services...
December 15, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29235454/a-large-multi-ethnic-genome-wide-association-study-identifies-novel-genetic-loci-for-intraocular-pressure
#9
Hélène Choquet, Khanh K Thai, Jie Yin, Thomas J Hoffmann, Mark N Kvale, Yambazi Banda, Catherine Schaefer, Neil Risch, K Saidas Nair, Ronald Melles, Eric Jorgenson
Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a leading cause of blindness. IOP heritability has been estimated to up to 67%, and to date only 11 IOP loci have been reported, accounting for 1.5% of IOP variability. Here, we conduct a genome-wide association study of IOP in 69,756 untreated individuals of European, Latino, Asian, and African ancestry. Multiple longitudinal IOP measurements were collected through electronic health records and, in total, 356,987 measurements were included...
December 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29222139/effect-of-losartan-on-rv-dysfunction-results-from-the-double-blind-randomized-redefine-trial-in-adults-with-repaired-tetralogy-of-fallot
#10
Jouke P Bokma, Michiel M Winter, Arie P van Dijk, Hubert W Vliegen, Joost P van Melle, Folkert Meijboom, Martijn C Post, Jacqueline K Berbee, S Matthijs Boekholdt, Maarten Groenink, Aeilko H Zwinderman, Barbara J M Mulder, Berto J Bouma
Background -The effect of angiotensin II receptor blockers (ARBs) on right ventricular (RV) function is still unknown. ARBs are beneficial in patients with acquired left ventricular (LV) dysfunction and recent findings suggested a favorable effect in symptomatic patients with systemic RV dysfunction. The current study aimed to determine the effect of losartan, an ARB, on subpulmonary RV dysfunction in adults after repair of tetralogy of Fallot (rTOF). Methods -REDEFINE is an investigator-initiated, multicenter, prospective, 1:1 randomized, double-blind, placebo-controlled study...
December 8, 2017: Circulation
https://www.readbyqxmd.com/read/29212609/effect-of-combined-exercise-versus-aerobic-only-training-on-skeletal-muscle-lipid-metabolism-in-a-rodent-model-of-type1-diabetes
#11
Michelle S Dotzert, Matthew W McDonald, Michael R Murray, J Zachary Nickels, Earl G Noble, C W James Melling
OBJECTIVES: Abnormal skeletal muscle lipid metabolism is associated with insulin resistance in people with type 1 diabetes. Although lipid metabolism is restored with aerobic exercise training, the risk for postexercise hypoglycemia is increased with this modality. Integrating resistance and aerobic exercise is associated with reduced hypoglycemic risk; however, the effects of this exercise modality on lipid metabolism and insulin resistance remain unknown. We compared the effects of combined (aerobic + resistance) versus aerobic exercise training on oxidative capacity and muscle lipid metabolism in a rat model of type 1 diabetes...
December 4, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29197548/right-heart-dysfunction-in-heart-failure-with-preserved-ejection-fraction-the-impact-of-atrial-fibrillation
#12
Thomas M Gorter, Joost P van Melle, Michiel Rienstra, Barry A Borlaug, Yoran M Hummel, Isabelle C Van Gelder, Elke S Hoendermis, Adriaan A Voors, Dirk J Van Veldhuisen, Carolyn S P Lam
BACKGROUND: Right ventricular (RV) dysfunction and atrial fibrillation (AF) frequently coexist in heart failure with preserved ejection fraction (HFpEF). The mechanisms underlying the association between AF and RV dysfunction are incompletely understood. METHODS AND RESULTS: 102 patients were identified. RV function was assessed using multiple echocardiographic parameters and dysfunction was present if ≥2 parameters were below the recommended cutoff. RV function, right atrial (RA) reservoir strain and RA emptying fraction, were compared between AF and sinus rhythm...
November 29, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29193535/monodisperse-n-doped-graphene-nanoribbons-reaching-7-7-nm-in-length
#13
Diego Cortizo-Lacalle, Juan Pedro Mora-Fuentes, Karol Strutynski, Akinori Saeki, Manuel Melle-Franco, Aurelio Mateo-Alonso
The properties of graphene nanoribbons are highly dependent on structural variables such as width, length, edge structure and heteroatom-doping. Therefore, atomic precision over all these variables is necessary for establishing their fundamental properties and exploring their potential applications. We describe here a new iterative approach that assembles a small and carefully designed molecular building block into monodisperse N-doped graphene nanoribbons with different lengths. To showcase this approach, we report the synthesis and characterisation of a series of nanoribbons constituted of 10, 20 and 30 conjugated linearly-fused rings (with 2...
November 29, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29187185/in-hospital-prescription-changes-and-documentation-in-the-medical-records-of-the-primary-care-provider-results-from-a-medical-record-review-study
#14
Judith M Poldervaart, Marije A van Melle, Sanne Willemse, Niek J de Wit, Dorien L M Zwart
No abstract text is available yet for this article.
November 29, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29186694/large-scale-cognitive-gwas-meta-analysis-reveals-tissue-specific-neural-expression-and-potential-nootropic-drug-targets
#15
Max Lam, Joey W Trampush, Jin Yu, Emma Knowles, Gail Davies, David C Liewald, John M Starr, Srdjan Djurovic, Ingrid Melle, Kjetil Sundet, Andrea Christoforou, Ivar Reinvang, Pamela DeRosse, Astri J Lundervold, Vidar M Steen, Thomas Espeseth, Katri Räikkönen, Elisabeth Widen, Aarno Palotie, Johan G Eriksson, Ina Giegling, Bettina Konte, Panos Roussos, Stella Giakoumaki, Katherine E Burdick, Antony Payton, William Ollier, Ornit Chiba-Falek, Deborah K Attix, Anna C Need, Elizabeth T Cirulli, Aristotle N Voineskos, Nikos C Stefanis, Dimitrios Avramopoulos, Alex Hatzimanolis, Dan E Arking, Nikolaos Smyrnis, Robert M Bilder, Nelson A Freimer, Tyrone D Cannon, Edythe London, Russell A Poldrack, Fred W Sabb, Eliza Congdon, Emily Drabant Conley, Matthew A Scult, Dwight Dickinson, Richard E Straub, Gary Donohoe, Derek Morris, Aiden Corvin, Michael Gill, Ahmad R Hariri, Daniel R Weinberger, Neil Pendleton, Panos Bitsios, Dan Rujescu, Jari Lahti, Stephanie Le Hellard, Matthew C Keller, Ole A Andreassen, Ian J Deary, David C Glahn, Anil K Malhotra, Todd Lencz
Here, we present a large (n = 107,207) genome-wide association study (GWAS) of general cognitive ability ("g"), further enhanced by combining results with a large-scale GWAS of educational attainment. We identified 70 independent genomic loci associated with general cognitive ability. Results showed significant enrichment for genes causing Mendelian disorders with an intellectual disability phenotype. Competitive pathway analysis implicated the biological processes of neurogenesis and synaptic regulation, as well as the gene targets of two pharmacologic agents: cinnarizine, a T-type calcium channel blocker, and LY97241, a potassium channel inhibitor...
November 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/29172178/a-10-year-follow-up-study-of-violent-victimization-in-first-episode-psychosis-risk-and-protective-factors
#16
Johannes Langeveld, Stål Bjørkly, Julie Evensen, Inge Joa, Jan Olav Johannessen, Tor Ketil Larsen, Ingrid Melle, Stein Opjordsmoen, Jan Ivar Røssberg, Bjørn Rishovd Rund, Erik Simonsen, Per Vaglum, Wenche Ten Velden, Tom McGlashan, Svein Friis
Violent victimization in persons with severe mental illness has long-term adverse consequences. Little is known about the long-term prevalence of victimization in first episode psychosis, or about factors affecting victimization throughout the course of illness. To assess the prevalence of violent victimization during a 10-year follow-up period in a group of first episode psychosis (FEP) patients, and to identify early predictors and risk factors for victimization. A prospective design was used with comprehensive assessments of violent victimization, treatment variables and functioning at baseline and during 10-year follow-up...
November 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29155067/contrasting-roles-of-fungal-siderophores-in-maintaining-iron-homeostasis-in-epichlo%C3%A3-festucae
#17
Natasha T Forester, Geoffrey A Lane, Melle Steringa, Iain L Lamont, Linda J Johnson
The symbiosis between Epichloë festucae and its host perennial ryegrass (Lolium perenne) is a model system for mutualistic interactions in which the fungal endophyte grows between plant shoot cells and acquires host nutrients to survive. E. festucae synthesises the siderophore epichloënin A (EA) via SidN, a non-ribosomal peptide synthetase (NRPS). EA is involved in the acquisition of iron, an essential micronutrient, as part of the process of maintaining a stable symbiotic interaction. Here, we mutated a different NRPS gene sidC and showed that it is required for production of a second siderophore ferricrocin (FC)...
November 15, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/29154156/delta-beta-correlation-as-a-candidate-endophenotype-of-social-anxiety-a-two-generation-family-study
#18
Anita Harrewijn, Melle J W van der Molen, Irene M van Vliet, Jeanine J Houwing-Duistermaat, P Michiel Westenberg
BACKGROUND: Social anxiety disorder (SAD) is characterized by an extreme and intense fear and avoidance of social situations. In this two-generation family study we examined delta-beta correlation during a social performance task as candidate endophenotype of SAD. METHODS: Nine families with a target participant (diagnosed with SAD), their spouse and children, as well as target's siblings with spouse and children performed a social performance task in which they gave a speech in front of a camera...
November 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29141778/pathophysiology-and-risk-of-atrial-fibrillation-detected-after-ischemic-stroke-paradise-a-translational-integrated-and-transdisciplinary-approach
#19
Maryse Paquet, Joshua O Cerasuolo, Victoria Thorburn, Sebastian Fridman, Rasha Alsubaie, Renato D Lopes, Lauren E Cipriano, Paula Salamone, C W James Melling, Ali R Khan, Lucas Sedeño, Jiming Fang, Maria Drangova, Manuel Montero-Odasso, Jennifer Mandzia, Alexander V Khaw, Juan M Racosta, Justin Paturel, Lucy Samoilov, Devin Stirling, Brittany Balint, Victoria Jaremek, Marlys L Koschinsky, Michael B Boffa, Kelly Summers, Agustín Ibañez, Marko Mrkobrada, Gustavo Saposnik, Kurt Kimpinski, Shawn N Whitehead, Luciano A Sposato
BACKGROUND: It has been hypothesized that ischemic stroke can cause atrial fibrillation. By elucidating the mechanisms of neurogenically mediated paroxysmal atrial fibrillation, novel therapeutic strategies could be developed to prevent atrial fibrillation occurrence and perpetuation after stroke. This could result in fewer recurrent strokes and deaths, a reduction or delay in dementia onset, and in the lessening of the functional, structural, and metabolic consequences of atrial fibrillation on the heart...
November 13, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29129510/increase-in-serum-hdl-level-is-associated-with-less-negative-symptoms-after-one-year-of-antipsychotic-treatment-in-first-episode-psychosis
#20
Priyanthi B Gjerde, Ingrid Dieset, Carmen Simonsen, Eva Z Hoseth, Trude Iversen, Trine V Lagerberg, Siv Hege Lyngstad, Ragni H Mørch, Silje Skrede, Ole A Andreassen, Ingrid Melle, Vidar M Steen
BACKGROUND: A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated with alleviation of psychosis symptoms after one year of antipsychotic drug treatment in a cohort of first-episode psychosis (FEP) patients. METHODS: A total of 132 non-affective antipsychotic-treated FEP patients were included through the Norwegian Thematically Organized Psychosis (TOP) project...
November 9, 2017: Schizophrenia Research
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