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M Aas, C Henry, F Bellivier, M Lajnef, S Gard, J-P Kahn, T V Lagerberg, S R Aminoff, T Bjella, M Leboyer, O A Andreassen, I Melle, B Etain
BACKGROUND: Many studies have shown associations between a history of childhood trauma and more severe or complex clinical features of bipolar disorders (BD), including suicide attempts and earlier illness onset. However, the psychopathological mechanisms underlying these associations are still unknown. Here, we investigated whether affective lability mediates the relationship between childhood trauma and the severe clinical features of BD. METHOD: A total of 342 participants with BD were recruited from France and Norway...
November 29, 2016: Psychological Medicine
Elisabeth Haug, Merete G Øie, Ole A Andreassen, Unni Bratlien, Kristin L Romm, Paul Møller, Ingrid Melle
Background: Anomalous self-experiences (ASEs) aggregate in schizophrenia spectrum disorders, but the relationship between ASEs, and depression has been studied to a limited extent. Lower self-esteem has been shown to be associated with depression in early psychosis. Our hypothesis is that ASEs in early phases of schizophrenia are linked to lower levels of self-esteem, which in turn is associated with depression. Aim: The aim is to examine the relationship between ASEs, self-esteem and depression in first-episode schizophrenia spectrum disorders...
2016: Frontiers in Human Neuroscience
Kristina C Skåtun, Tobias Kaufmann, Nhat Trung Doan, Dag Alnæs, Aldo Córdova-Palomera, Erik G Jönsson, Helena Fatouros-Bergman, Lena Flyckt, Ingrid Melle, Ole A Andreassen, Ingrid Agartz, Lars T Westlye
Schizophrenia (SZ) is a severe mental illness with high heritability and complex etiology. Mounting evidence from neuroimaging has implicated disrupted brain network connectivity in the pathophysiology. However, previous findings are inconsistent, likely due to a combination of methodological and clinical variability and relatively small sample sizes. Few studies have used a data-driven approach for characterizing pathological interactions between regions in the whole brain and evaluated the generalizability across independent samples...
November 21, 2016: Schizophrenia Bulletin
Patrick C Thompson, Ronald L Dalman, E John Harris, Venita Chandra, Jason T Lee, Matthew W Mell
OBJECTIVE: The clinical decision-making utility of scoring algorithms for predicting mortality after ruptured abdominal aortic aneurysms (rAAAs) remains unknown. We sought to determine the clinical utility of the algorithms compared with our clinical decision making and outcomes for management of rAAA during a 10-year period. METHODS: Patients admitted with a diagnosis rAAA at a large university hospital were identified from 2005 to 2014. The Glasgow Aneurysm Score, Hardman Index, Vancouver Score, Edinburgh Ruptured Aneurysm Score, University of Washington Ruptured Aneurysm Score, Vascular Study Group of New England rAAA Risk Score, and the Artificial Neural Network Score were analyzed for accuracy in predicting mortality...
December 2016: Journal of Vascular Surgery
Nils Eiel Steen, Monica Aas, Carmen Simonsen, Ingrid Dieset, Martin Tesli, Mari Nerhus, Erlend Gardsjord, Ragni Mørch, Ingrid Agartz, Ingrid Melle, Anja Vaskinn, Olav Spigset, Ole A Andreassen
BACKGROUND: Mood stabilizers like lithium and anticonvulsants are used in bipolar and related psychotic disorders. There is a lack of knowledge of the relationship of these medications and cognition in the psychosis spectrum. We studied the association between serum concentration of mood stabilizers and cognitive performance in a well-characterized sample of bipolar and schizophrenia spectrum disorders. METHODS: Serum concentrations of valproate, lamotrigine, and lithium were analyzed for associations to performance on neuropsychological tests in six cognitive domains in individuals with bipolar disorder (n = 167) and in a combined sample of individuals with bipolar or schizophrenia spectrum disorders (n = 217)...
December 2016: International Journal of Bipolar Disorders
Marit Haram, Francesco Bettella, Christine Lycke Brandt, Daniel S Quintana, Mari Nerhus, Thomas Bjella, Srdjan Djurovic, Lars T Westlye, Ole A Andreassen, Ingrid Melle, Martin Tesli
BACKGROUND: Oxytocin has been proposed to mediate amygdala dysfunction associated with altered emotion processing in schizophrenia, but the contribution of oxytocin pathway genes is yet to be investigated. AIMS: To identify potential different contributions of three oxytocin receptor polymorphisms (rs53576, rs237902 and rs2254298) between patients with schizophrenia spectrum disorders (SCZ), affective spectrum disorders (AD) and healthy controls (HC). METHOD: In a total of 346 participants (104 with SCZ, 100 with AD, and 142 HC) underwent genotyping and functional magnetic resonance imaging (fMRI) during an emotional faces matching paradigm...
November 2016: BJPsych Open
L Melle, C Le Ray, P Delorme, O Anselem, F Goffinet, L Marcellin
OBJECTIVE: To evaluate whether the position of preventive cerclage determined by immediate postoperative transvaginal cervical ultrasound is predictive of preterm birth. METHODS: A single-center retrospective study conducted between 1 August 2007 and 31 December 2015 in a maternity type III who included women carrying out for a single pregnancy and who receive a McDonald preventive cerclage. Measurements of internal os-stitch, stitch-external os and the total length of the cervix were performed during immediate postoperative transvaginal cervical ultrasound...
November 8, 2016: Gynécologie, Obstétrique & Fertilité
Anthony C May, Rachel L Ehrlich, Sergey Balashov, Garth D Ehrlich, Mayilvahanan Shanmugam, Daniel H Fine, Narayanan Ramasubbu, Joshua Chang Mell, Carla Cugini
We report here the complete genomic sequence and methylome of Aggregatibacter actinomycetemcomitans strain IDH781. This rough strain is used extensively as a model organism to characterize localized aggressive periodontitis pathogenesis, the basic biology and oral cavity colonization of A. actinomycetemcomitans, and its interactions with other members of the oral microbiome.
November 10, 2016: Genome Announcements
M Aas, K Kauppi, C L Brandt, M Tesli, T Kaufmann, N E Steen, I Agartz, L T Westlye, O A Andreassen, I Melle
BACKGROUND: Childhood trauma increases risk of a range of mental disorders including psychosis. Whereas the mechanisms are unclear, previous evidence has implicated atypical processing of emotions among the core cognitive models, in particular suggesting altered attentional allocation towards negative stimuli and increased negativity bias. Here, we tested the association between childhood trauma and brain activation during emotional face processing in patients diagnosed with psychosis continuum disorders...
November 11, 2016: Psychological Medicine
E H Lange, S Nerland, K N Jørgensen, L Mørch-Johnsen, R Nesvåg, C B Hartberg, U K Haukvik, K Osnes, I Melle, O A Andreassen, I Agartz
BACKGROUND: Excessive alcohol use is associated with brain damage but less is known about brain effects from moderate alcohol use. Previous findings indicate that patients with severe mental illness, particularly schizophrenia, are vulnerable to alcohol-related brain damage. We investigated the association between levels of alcohol consumption and cortical and subcortical brain structures in schizophrenia and bipolar disorder patients and healthy controls, and investigated for group differences for this association...
November 10, 2016: Psychological Medicine
Levi Røstad Kvitland, Petter Andreas Ringen, Sofie Ragnhild Aminoff, Christine Demmo, Tone Hellvin, Trine Vik Lagerberg, Ole Andreas Andreassen, Ingrid Melle
There is little knowledge about the role of the duration of untreated bipolar (DUB) illness in first-treatment bipolar disorder I (BD I), its association with symptoms at start of first treatment, and development over the first year, and limited knowledge about factors that influence the length of DUB. Substance use has shown to delay identification of primary psychiatric disorders, and while cannabis use is common in BD the role of cannabis in relationship to DUB is unclear. The aim of the present study is to examine the associations between DUB and key clinical outcomes at baseline in BD I, and at one year follow-up, and to evaluate the influence of cannabis use...
October 28, 2016: Psychiatry Research
Bjarni Gunnarsson, Guðrún A Jónsdóttir, Gyða Björnsdóttir, Bettina Konte, Patrick Sulem, Snædís Kristmundsdóttir, Birte Kehr, Ómar Gústafsson, Hannes Helgason, Paul D Iordache, Sigurgeir Ólafsson, Michael L Frigge, Guðmar Þorleifsson, Sunna Arnarsdóttir, Berglind Stefánsdóttir, Ina Giegling, Srdjan Djurovic, Kjetil S Sundet, Thomas Espeseth, Ingrid Melle, Annette M Hartmann, Unnur Thorsteinsdottir, Augustine Kong, Daníel F Guðbjartsson, Ulrich Ettinger, Ole A Andreassen, Dan Rujescu, Jónas G Halldórsson, Hreinn Stefánsson, Bjarni V Halldórsson, Kári Stefánsson
Only a few common variants in the sequence of the genome have been shown to impact cognitive traits. Here we demonstrate that polygenic scores of educational attainment predict specific aspects of childhood cognition, as measured with IQ. Recently, three sequence variants were shown to associate with educational attainment, a confluence phenotype of genetic and environmental factors contributing to academic success. We show that one of these variants associating with educational attainment, rs4851266-T, also associates with Verbal IQ in dyslexic children (P = 4...
November 4, 2016: Scientific Reports
Trine Vik Lagerberg, Sofie Ragnhild Aminoff, Monica Aas, Thomas Bjella, Chantal Henry, Marion Leboyer, Geir Pedersen, Frank Bellivier, Romain Icick, Ole A Andreassen, Bruno Etain, Ingrid Melle
BACKGROUND: Affective dysregulation is a core feature of bipolar disorder (BD), and inter-episodic affect lability is associated with more severe outcomes including comorbidity. Rates of daily tobacco smoking and substance use disorders in BD are high. Knowledge regarding relationships between affective lability and abuse of the most commonly used substances such as tobacco, alcohol and cannabis in BD is limited. METHODS: We investigated whether dimensions of inter-episodic affective lability as measured with the Affective Lability Scale - short form (ALS-SF) were associated with lifetime daily tobacco use or alcohol (AUD) or cannabis use disorders (CUD) in a sample of 372 French and Norwegian patients with BD I and II...
October 14, 2016: Journal of Affective Disorders
Jouke P Bokma, Michiel M Winter, Jim T Vehmeijer, Hubert W Vliegen, Arie P van Dijk, Joost P van Melle, Folkert J Meijboom, Martijn C Post, Aeilko H Zwinderman, Barbara J M Mulder, Berto J Bouma
BACKGROUND: Although QRS duration >180 ms has prognostic value in adults with tetralogy of Fallot (TOF), its sensitivity to predict mortality is low. Fragmented QRS complexes, a simple measurement on ECG, are related to myocardial fibrosis and dysfunction in patients with TOF. Our objective was to determine whether QRS fragmentation predicts major outcomes in TOF. METHODS: This multicentre study included adult patients with TOF from a prospective registry. Notches in the QRS complex in ≥2 contiguous leads on a 12-lead ECG, not related to bundle branch block, were defined as QRS fragmentation, which was classified as none, moderate (≤4 leads) or severe (≥5 leads)...
November 1, 2016: Heart: Official Journal of the British Cardiac Society
Casey W Williamson, Garrett Green, Sonal S Noticewala, Nan Li, Hanjie Shen, Florin Vaida, Loren K Mell
PURPOSE: Validated models are needed to justify strategies to define planning target volumes (PTVs) for intact cervical cancer used in clinical practice. Our objective was to independently validate a previously published shape model, using data collected prospectively from clinical trials. METHODS AND MATERIALS: We analyzed 42 patients with intact cervical cancer treated with daily fractionated pelvic intensity modulated radiation therapy and concurrent chemotherapy in one of 2 prospective clinical trials...
November 15, 2016: International Journal of Radiation Oncology, Biology, Physics
Karen Trang, E John Harris, Ronald L Dalman, Jason T Lee, Matthew W Mell, Venita Chandra
No abstract text is available yet for this article.
August 2016: Journal of Vascular Surgery
Larry W Kraiss, Ragheed Al-Dulaimi, Angela P Presson, Shipra Arya, George K Lee, Philip P Goodney, Matthew Mell, Jason Johanning, Julie L Beckstrom, Benjamin S Brooke
No abstract text is available yet for this article.
August 2016: Journal of Vascular Surgery
Matthew Mell, Elsie Gyang Ross, Marco Zavatta
No abstract text is available yet for this article.
August 2016: Journal of Vascular Surgery
Nathan K Itoga, Tanner Kim, Anna M Sailer, Dominik Fleischmann, Matthew W Mell
No abstract text is available yet for this article.
August 2016: Journal of Vascular Surgery
Jone Bjornestad, Inge Joa, Tor K Larsen, Johannes Langeveld, Larry Davidson, Wenche Ten Velden Hegelstad, Liss G Anda, Marius Veseth, Ingrid Melle, Jan O Johannessen, Kolbjorn Bronnick
Background: Predictors of long-term symptomatic remission are crucial to the successful tailoring of treatment in first episode psychosis. There is lack of studies distinguishing the predictive effects of different social factors. This prevents a valid evaluating of their independent effects. Objectives: To test specific social baseline predictors of long-term remission. We hypothesized that first, satisfaction with social relations predicts remission; second, that frequency of social interaction predicts remission; and third, that the effect of friend relationship satisfaction and frequency will be greater than that of family relations satisfaction and frequency...
2016: Frontiers in Psychology
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