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https://www.readbyqxmd.com/read/29129510/increase-in-serum-hdl-level-is-associated-with-less-negative-symptoms-after-one-year-of-antipsychotic-treatment-in-first-episode-psychosis
#1
Priyanthi B Gjerde, Ingrid Dieset, Carmen Simonsen, Eva Z Hoseth, Trude Iversen, Trine V Lagerberg, Siv Hege Lyngstad, Ragni H Mørch, Silje Skrede, Ole A Andreassen, Ingrid Melle, Vidar M Steen
BACKGROUND: A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated with alleviation of psychosis symptoms after one year of antipsychotic drug treatment in a cohort of first-episode psychosis (FEP) patients. METHODS: A total of 132 non-affective antipsychotic-treated FEP patients were included through the Norwegian Thematically Organized Psychosis (TOP) project...
November 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29127343/global-phylogenetic-analysis-of-escherichia-coli-and-plasmids-carrying-the-mcr-1-gene-indicates-bacterial-diversity-but-plasmid-restriction
#2
Sébastien Matamoros, Jarne M van Hattem, Maris S Arcilla, Niels Willemse, Damian C Melles, John Penders, Trung Nguyen Vinh, Ngo Thi Hoa, Menno D de Jong, Constance Schultsz
To understand the dynamics behind the worldwide spread of the mcr-1 gene, we determined the population structure of Escherichia coli and of mobile genetic elements (MGEs) carrying the mcr-1 gene. After a systematic review of the literature we included 65 E. coli whole genome sequences (WGS), adding 6 recently sequenced travel related isolates, and 312 MLST profiles. We included 219 MGEs described in 7 Enterobacteriaceae species isolated from human, animal and environmental samples. Despite a high overall diversity, 2 lineages were observed in the E...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122637/side-effect-burden-of-antipsychotic-drugs-in-real-life-impact-of-gender-and-polypharmacy
#3
Trude Seselie Jahr Iversen, Nils Eiel Steen, Ingrid Dieset, Sigrun Hope, Ragni Mørch, Erlend Strand Gardsjord, Kjetil Nordbø Jørgensen, Ingrid Melle, Ole A Andreassen, Espen Molden, Erik G Jönsson
BACKGROUND: Antipsychotic-associated side effects are well known and represent a significant treatment challenge. Still, few large studies have investigated the overall side effect burden of antipsychotics in real-life settings. OBJECTIVE: To describe the occurrence of side effects and perceived burden of antipsychotics in a large naturalistic sample, taking polypharmacy and patient characteristics into account. METHOD: Patients (n=1087) with psychotic disorders were assessed for side effects using the Udvalg for Kliniske Undersøgelser (UKU) side effect rating scale in addition to assessment of clinical and pharmacological data...
November 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29121444/neurocognitive-functioning-clinical-course-and-functional-outcome-in-first-treatment-bipolar-i-disorder-patients-with-and-without-clinical-relapse-a-1-year-follow-up-study
#4
Christine Demmo, Trine V Lagerberg, Levi R Kvitland, Sofie R Aminoff, Tone Hellvin, Carmen Simonsen, Beathe Haatveit, Ole A Andreassen, Ingrid Melle, Torill Ueland
OBJECTIVES: Due to limited research on the association between recurrence of mood episodes and the longitudinal course of neurocognitive functioning in early phase bipolar I disorder (BD I), the impact of recurrence on neurocognition remains unclear. Further, a strong correlation between neurocognitive impairment and functional impairment has been demonstrated. The longitudinal relationship between neurocognitive impairment and functional outcome in relation to recurrence is, however, not established...
November 9, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29117996/effect-of-isolated-ultrafiltration-and-isovolemic-dialysis-on-myocardial-perfusion-and-left-ventricular-function-assessed-with-13n-nh3-pet-and-echocardiography
#5
Solmaz Assa, Hannie Kuipers, Esmee Ettema, Carlo A Gaillard, Wim P Krijnen, Yoran M Hummel, Adriaan A Voors, Joost P van Melle, Ralf Westerhuis, Antoon Willemsen, Riemer H J A Slart, Casper Fm Franssen
Hemodialysis is associated with a fall in myocardial perfusion and may induce regional left ventricular (LV) systolic dysfunction. The pathophysiology of this entity is incompletely understood and the contribution of ultrafiltration and diffusive dialysis has not been studied. We investigated the effect of isolated ultrafiltration and isovolemic dialysis on myocardial perfusion and LV function. Eight patients (7 male, age 55±18 years) underwent 60 min of isolated ultrafiltration and 60 min of isovolemic dialysis in randomized order...
November 8, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29102276/effect-of-cd4-count-on-treatment-toxicity-and-tumor-recurrence-in-human-immunodeficiency-virus-positive-patients-with-anal-cancer
#6
Alex K Bryant, Ross Mudgway, Minh-Phuong Huynh-Le, Daniel R Simpson, Loren K Mell, Samir Gupta, Andrew B Sharabi, James D Murphy
PURPOSE: To study the effects of immunosuppression on treatment toxicity, long-term cancer recurrence risk, and survival among human immunodeficiency virus (HIV)-positive anal cancer patients. METHODS AND MATERIALS: From a nationwide retrospective cohort of veterans with anal cancer we identified 142 HIV-positive patients with stage I-III disease, diagnosed between 2000 and 2015 and treated with definitive-intent chemotherapy and radiation. We used regression models to study the impact of pretreatment CD4 counts and longitudinal posttreatment CD4 counts on outcomes including acute toxicity, long-term ostomy rates, cancer recurrence, cancer-specific survival, and overall survival...
September 22, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29089503/designing-broad-spectrum-anti-hiv-1-grnas-to-target-patient-derived-variants
#7
Will Dampier, Neil T Sullivan, Cheng-Han Chung, Joshua Chang Mell, Michael R Nonnemacher, Brian Wigdahl
Clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR-associated protein 9 (Cas9), including specific guide RNAs (gRNAs), can excise integrated human immunodeficiency virus type 1 (HIV-1) provirus from host chromosomes. To date, anti-HIV-1 gRNAs have been designed to account for off-target activity, however, they seldom account for genetic variation in the HIV-1 genome within and between patients, which will be crucial for therapeutic application of this technology. This analysis tests the ability of published anti-HIV-1 gRNAs to cleave publicly available patient-derived HIV-1 sequences to inform gRNA design and provides basic computational tools to researchers in the field...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29083406/shared-genetic-origin-of-asthma-hay-fever-and-eczema-elucidates-allergic-disease-biology
#8
Manuel A Ferreira, Judith M Vonk, Hansjörg Baurecht, Ingo Marenholz, Chao Tian, Joshua D Hoffman, Quinta Helmer, Annika Tillander, Vilhelmina Ullemar, Jenny van Dongen, Yi Lu, Franz Rüschendorf, Jorge Esparza-Gordillo, Chris W Medway, Edward Mountjoy, Kimberley Burrows, Oliver Hummel, Sarah Grosche, Ben M Brumpton, John S Witte, Jouke-Jan Hottenga, Gonneke Willemsen, Jie Zheng, Elke Rodríguez, Melanie Hotze, Andre Franke, Joana A Revez, Jonathan Beesley, Melanie C Matheson, Shyamali C Dharmage, Lisa M Bain, Lars G Fritsche, Maiken E Gabrielsen, Brunilda Balliu, Jonas B Nielsen, Wei Zhou, Kristian Hveem, Arnulf Langhammer, Oddgeir L Holmen, Mari Løset, Gonçalo R Abecasis, Cristen J Willer, Andreas Arnold, Georg Homuth, Carsten O Schmidt, Philip J Thompson, Nicholas G Martin, David L Duffy, Natalija Novak, Holger Schulz, Stefan Karrasch, Christian Gieger, Konstantin Strauch, Ronald B Melles, David A Hinds, Norbert Hübner, Stephan Weidinger, Patrik K E Magnusson, Rick Jansen, Eric Jorgenson, Young-Ae Lee, Dorret I Boomsma, Catarina Almqvist, Robert Karlsson, Gerard H Koppelman, Lavinia Paternoster
Asthma, hay fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the same individuals, partly because of a shared genetic origin. To identify shared risk variants, we performed a genome-wide association study (GWAS; n = 360,838) of a broad allergic disease phenotype that considers the presence of any one of these three diseases. We identified 136 independent risk variants (P < 3 × 10(-8)), including 73 not previously reported, which implicate 132 nearby genes in allergic disease pathophysiology...
October 30, 2017: Nature Genetics
https://www.readbyqxmd.com/read/29081991/severe-steroid-resistant-anti-pd1-t-cell-checkpoint-inhibitor-induced-hepatotoxicity-driven-by-biliary-injury
#9
Gary Joseph Doherty, Adam M Duckworth, Susan E Davies, George F Mells, Rebecca Brais, Susan V Harden, Christine A Parkinson, Pippa G Corrie
INTRODUCTION: Hepatotoxicity from T-cell checkpoint blockade is an increasingly common immune-related adverse event, but remains poorly characterised and can be challenging to manage. Such toxicity is generally considered to resemble autoimmune hepatitis, although this assumption is extrapolated from limited clinicopathological reports of anti-cytotoxic T-lymphocyte-associated protein 4-induced hepatotoxicity. METHODS: Here we report, with full clinicopathological correlation, three cases of T-cell checkpoint inhibitor-induced hepatotoxicity associated with anti-programmed cell death protein 1 agents...
2017: ESMO Open
https://www.readbyqxmd.com/read/29073046/nonequilibrium-fluctuations-of-lipid-membranes-by-the-rotating-motor-protein-f1f0-atp-synthase
#10
Víctor G Almendro-Vedia, Paolo Natale, Michael Mell, Stephanie Bonneau, Francisco Monroy, Frederic Joubert, Iván López-Montero
ATP synthase is a rotating membrane protein that synthesizes ATP through proton-pumping activity across the membrane. To unveil the mechanical impact of this molecular active pump on the bending properties of its lipid environment, we have functionally reconstituted the ATP synthase in giant unilamellar vesicles and tracked the membrane fluctuations by means of flickering spectroscopy. We find that ATP synthase rotates at a frequency of about 20 Hz, promoting large nonequilibrium deformations at discrete hot spots in lipid vesicles and thus inducing an overall membrane softening...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29071987/-clinical-research-on-double-needle-winding-and-pulling-combined-with-electroacupuncture-therapy-in-treating-scapulohumeral-periarthritis
#11
Ning Wang, Xiao-Ping Wu, Peng-Jie Sheng
OBJECTIVE: To observe the efficacy of double-needle winding and pulling combined with electroacupuncture in treating scapulohumeral periarthritis. METHODS: Sixty cases with scapulohumeral periarthritis were equally randomized into treatment group and control group (n=30 in each group). Jianliao (TE 14), Jianyu(LI 15), Naoshu(SI 10), Jianzhen(SI 9), Binao(LI 14), Quyuan(SI 13), Quchi(LI 11), Shousanli(LI 10) were selected in the two groups. In the treatment group,double-needles were inserted respectively into TE 14,LI 15 and SI 10, twirling till sticking,then the needles were pulled for 3 times...
June 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29068800/the-impact-of-positive-resection-margins-on-survival-and-recurrence-following-resection-and-adjuvant-chemotherapy-for-pancreatic-ductal-adenocarcinoma
#12
Paula Ghaneh, Jorg Kleeff, Christopher M Halloran, Michael Raraty, Richard Jackson, James Melling, Owain Jones, Daniel H Palmer, Trevor F Cox, Chloe J Smith, Derek A O'Reilly, Jakob R Izbicki, Andrew G Scarfe, Juan W Valle, Alexander C McDonald, Ross Carter, Niall C Tebbutt, David Goldstein, Robert Padbury, Jennifer Shannon, Christos Dervenis, Bengt Glimelius, Mark Deakin, Alan Anthoney, Markus M Lerch, Julia Mayerle, Attila Oláh, Charlotte L Rawcliffe, Fiona Campbell, Oliver Strobel, Markus W Büchler, John P Neoptolemos
OBJECTIVE AND BACKGROUND: Local and distant disease recurrence are frequently observed following pancreatic cancer resection, but an improved understanding of resection margin assessment is required to aid tailored therapies. METHODS: Analyses were carried out to assess the association between clinical characteristics and margin involvement as well as the effects of individual margin involvement on site of recurrence and overall and recurrence-free survival using individual patient data from the European Study Group for Pancreatic Cancer (ESPAC)-3 randomized controlled trial...
October 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29068436/gwas-meta-analysis-reveals-novel-loci-and-genetic-correlates-for-general-cognitive-function-a-report-from-the-cogent-consortium
#13
J W Trampush, M L Z Yang, J Yu, E Knowles, G Davies, D C Liewald, J M Starr, S Djurovic, I Melle, K Sundet, A Christoforou, I Reinvang, P DeRosse, A J Lundervold, V M Steen, T Espeseth, K Räikkönen, E Widen, A Palotie, J G Eriksson, I Giegling, B Konte, P Roussos, S Giakoumaki, K E Burdick, A Payton, W Ollier, M Horan, O Chiba-Falek, D K Attix, A C Need, E T Cirulli, A N Voineskos, N C Stefanis, D Avramopoulos, A Hatzimanolis, D E Arking, N Smyrnis, R M Bilder, N A Freimer, T D Cannon, E London, R A Poldrack, F W Sabb, E Congdon, E D Conley, M A Scult, D Dickinson, R E Straub, G Donohoe, D Morris, A Corvin, M Gill, A R Hariri, D R Weinberger, N Pendleton, P Bitsios, D Rujescu, J Lahti, S Le Hellard, M C Keller, O A Andreassen, I J Deary, D C Glahn, A K Malhotra, T Lencz
This corrects the article DOI: 10.1038/mp.2016.244.
November 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29067761/what-have-we-learned-about-heart-failure-with-mid-range-ejection-fraction-one-year-after-its-introduction
#14
REVIEW
Jan F Nauta, Yoran M Hummel, Joost P van Melle, Peter van der Meer, Carolyn S P Lam, Piotr Ponikowski, Adriaan A Voors
The 2016 European Society of Cardiology heart failure guidelines introduced the term 'heart failure with mid-range ejection fraction' (HFmrEF) to refer to patients with heart failure and a mildly reduced ejection fraction of 40-49%. About 20% of heart failure patients fall in this category. One of the main reasons for the introduction of this category was to stimulate research into this grey area. This review aims to highlight the key findings that have been published so far. Firstly, HFmrEF more closely resembles heart failure with reduced (HFrEF) than preserved ejection fraction (HFpEF) with regard to ischaemic aetiology, which is more frequent in both HFmrEF and HFrEF compared to HFpEF...
October 24, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29043524/improving-the-success-rate-of-human-corneal-endothelial-cell-cultures-from-single-donor-corneas-with-stabilization-medium
#15
D Spinozzi, A Miron, M Bruinsma, J T Lie, I Dapena, S Oellerich, G R J Melles
Main objective of this study was to improve the success rate of human corneal endothelial cell (hCEC) cultures from single donor corneas. We could show that the use of stabilization medium prior to cell isolation may have a positive effect on the success rate of hCEC cultures from single research-grade donor corneas by allowing growth of otherwise possibly not successful cultures and by improving their proliferative rate. hCEC were obtained from corneo-scleral rims of 7 discarded human research-grade cornea pairs...
October 17, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29035420/modeling-the-secondary-structures-of-the-peptaibols-antiamoebin-i-and-zervamicin-ii-modified-with-d-amino-acids-and-proline-analogues
#16
Tarsila G Castro, Nuno M Micaêlo, Manuel Melle-Franco
Antiamoebin I (AAM-I) and zervamicin II (Zrv-IIB) are peptaibols that exert antibiotic activity through the insertion/disruption of cell membranes. In this study, we investigated how the folding of these peptaibols are affected when some of their native residues are replaced with proline analogues and asymmetrical D-α,α-dialkyl glycines (two classes of noncanonical amino acids). Systematic substitutions of native Aib, Pro, Hyp, and Iva residues were performed to elucidate the folding properties of the modified peptaibols incorporating noncanonical residues...
October 16, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29030101/genome-wide-association-study-and-meta-analysis-in-multiple-populations-identifies-new-loci-for-peanut-allergy-and-establishes-c11orf30-emsy-as-a-genetic-risk-factor-for-food-allergy
#17
Yuka Asai, Aida Eslami, C Dorien van Ginkel, Loubna Akhabir, Ming Wan, George Ellis, Moshe Ben-Shoshan, David Martino, Manuel A Ferreira, Katrina Allen, Bruce Mazer, Hans de Groot, Nicolette W de Jong, Roy N Gerth van Wijk, Anthony E J Dubois, Rick Chin, Steven Cheuk, Joshua Hoffman, Eric Jorgensen, John S Witte, Ronald B Melles, Xiumei Hong, Xiaobin Wang, Jennie Hui, Arthur W Bill Musk, Michael Hunter, Alan L James, Gerard H Koppelman, Andrew J Sandford, Ann E Clarke, Denise Daley
BACKGROUND: Peanut allergy (PA) is a complex disease with both environmental and genetic risk factors. Previously PA loci were identified in FLG and HLA in candidate gene studies, and loci in HLA in a genome-wide association study and meta-analysis. OBJECTIVE: To investigate genetic susceptibility to PA. METHODS: Eight hundred and fifty cases and 926 hyper-controls and >7.8 million genotyped and imputed single nucleotide polymorphisms (SNPs) were analyzed in a genome-wide association study to identify susceptibility variants for PA in the Canadian population...
October 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28990995/donor-tissue-preparation-for-descemet-membrane-endothelial-keratoplasty-an-updated-review
#18
Rénuka S Birbal, Shameema Sikder, Jessica T Lie, Esther A Groeneveld-van Beek, Silke Oellerich, Gerrit R J Melles
PURPOSE: To provide an overview of the current literature on donor tissue preparation for Descemet membrane endothelial keratoplasty (DMEK). METHODS: A comprehensive database search without date restrictions was performed in PubMed and in The Cochrane Library in May, 2017. Keywords included Descemet membrane endothelial keratoplasty, corneal transplantation, graft, harvest, dissection, preparation, endothelial cell, and endothelial cell density. Articles aiming to describe or evaluate a technique for DMEK graft preparation were considered eligible and were included in this review...
October 5, 2017: Cornea
https://www.readbyqxmd.com/read/28988612/cost-analysis-complications-and-discharge-disposition-associated-with-simultaneous-vs-staged-bilateral-total-knee-arthroplasty
#19
Ali H Sobh, Matthew P Siljander, Anthony J Mells, Denise M Koueiter, Drew D Moore, Mark S Karadsheh
BACKGROUND: Simultaneous vs staged bilateral total knee arthroplasty (BTKA) has long been debated. The primary objective of this study was to compare actual hospital costs and complication rates in patients undergoing simultaneous BTKA (simBTKA) and staged BTKA (staBTKA) at a single institution. METHODS: A total joint arthroplasty database from a single hospital was used to identify all patients who underwent primary BTKA from 2013 to 2016 and divided into simultaneous and staged groups...
September 13, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28987372/qualitative-and-quantitative-characterization-of-secondary-metabolites-and-carbohydrates-in-bai-hu-tang-using-ultraperformance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry-and-ultraperformance-liquid-chromatography-coupled
#20
Wei-Fang Zhong, Wing-Sum Tong, Shan-Shan Zhou, Ka-Man Yip, Song-Lin Li, Zhong-Zhen Zhao, Jun Xu, Hu-Biao Chen
Bai-Hu-Tang (BHT), a classic traditional Chinese medicine (TCM) formula used for clearing heat and promoting body fluid, consists of four traditional Chinese medicines, i.e., Gypsum Fibrosum (Shigao), Anemarrhenae Rhizoma (Zhimu), Glycyrrhizae Radix et Rhizoma Praeparata cum Melle (Zhigancao), and nonglutinous rice (Jingmi). The chemical composition of BHT still remains largely elusive thus far. To qualitatively and quantitatively characterize secondary metabolites and carbohydrates in BHT, here a combination of analytical approaches using ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and ultraperformance liquid chromatography coupled with photodiode array detector was developed and validated...
October 2017: Journal of Food and Drug Analysis
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