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https://www.readbyqxmd.com/read/29169176/ablation-of-atg4b-suppressed-autophagy-and-activated-ampk-for-cell-cycle-arrest-in-cancer-cells
#1
Pei-Feng Liu, Chien-Jen Hsu, Wei-Lun Tsai, Jin-Shiung Cheng, Jih-Jung Chen, I-Fei Huang, Ho-Hsing Tseng, Hsueh-Wei Chang, Chih-Wen Shu
BACKGROUND/AIMS: ATG4B is a cysteine protease required for autophagy, which is a cellular catabolic pathway involved in energy balance. ATG4B expression is elevated during tumor growth in certain types of cancer, suggesting that ATG4B is an attractive target for cancer therapy. However, little is known about the mechanisms through which ATG4B deprivation suppresses the growth of cancer cells. METHODS: Cancer cells were transfected with either siRNA against ATG4B or an expression vector encoding wild-type ATG4BWT or encoding catalytic mutant ATG4BC74A to determine cell cycle progression by propidium iodide staining or by BrdU incorporation assay using flow cytometry...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29167909/outcomes-of-neoadjuvant-chemoradiotherapy-followed-by-total-mesorectal-excision-surgery-for-locally-advanced-rectal-cancer-a-single-institution-experience
#2
Michelle Shu Fen Tseng, Huili Zheng, Ivy Wei Shan Ng, Yiat Horng Leong, Cheng Nang Leong, Wei Peng Yong, Wai Kit Cheong, Jeremy Chee Seong Tey
INTRODUCTION: Neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision (TME) surgery for locally advanced rectal cancer has been shown to improve local control and reduce toxicity, as compared to adjuvant CRT. We report the outcomes of our patients with locally advanced rectal cancer treated at National University Hospital, Singapore. METHODS: From April 2002 to December 2014, 117 patients with T3/4, N0/+, M0 rectal cancer received neoadjuvant CRT followed by TME surgery...
November 13, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/29166615/olfactory-experience-and-developmental-stage-dependent-control-of-cpeb4-regulates-c-fos-mrna-translation-for-granule-cell-survival
#3
Ching-San Tseng, Hsu-Wen Chao, Hsien-Sung Huang, Yi-Shuian Huang
Mammalian olfactory bulbs (OBs) require continuous replenishment of interneurons (mainly granule cells [GCs]) to support local circuits throughout life. Two spatiotemporally distinct waves of postnatal neurogenesis contribute to expanding and maintaining the GC pool. Although neonate-born GCs have a higher survival rate than adult-born GCs, the molecular mechanism underlying this survival remains unclear. Here, we find that cytoplasmic polyadenylation element-binding protein 4 (CPEB4) acts as a survival factor exclusively for early postnatal GCs...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29164767/the-association-between-steatosis-and-diabetes-with-hepatocellular-carcinoma-in-non-genotype-3-chronic-hepatitis-c-patients
#4
Yi-Hao Yen, Ming-Tsung Lin, Fang-Ying Kuo, Kuo-Chin Chang, Ming-Chao Tsai, Po-Lin Tseng, Cheng-Kun Wu, Jung-Ting Lin, Tsung-Hui Hu, Sheng-Nan Lu, Jing-Houng Wang, Chao-Hung Hung, Chien-Hung Chen
BACKGROUND AND AIMS: Diabetes mellitus (DM) has been found to be strongly associated with an increased risk of hepatocellular carcinoma (HCC) among chronic hepatitis C (CHC) patients. Several studies have also found an association between metabolic steatosis and the risk of HCC in CHC patients, whether this latter association has been accounted for by the known relationship between DM and HCC is still unknown. METHODS: A cohort consisting of 976 non-genotype 3 patients histologically proven to have CHC and treated with interferon and ribavirin was studied...
November 22, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29164549/-improving-the-accuracy-rate-of-analgesics-and-sedatives-administration-in-an-intensive-care-unit
#5
Hsiu-Chuan Lai, Ya-Huei Chen, Yi-Jene Li, Hui-Mei Huang, Chien-Hua Tseng, Ming-Cheng Chan
BACKGROUND: Patients with respiratory failure needing mechanical ventilation are common in the intensive care unit. These patients often require sedative and analgesic agents to alleviate their discomfort and to avoid causing associated safety issues. However, prolonged post-awakening confusion and changes in perception after withdrawal from sedatives and analgesic agents are common in daily practice. Thus, the optimal use of sedative and analgesic agents remains an important issue in the intensive care unit...
December 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29163769/yap1-is-essential-for-tumor-growth-and-is-a-potential-therapeutic-target-for-egfr-dependent-lung-adenocarcinomas
#6
Ting-Fang Lee, Yu-Chi Tseng, Wei-Chin Chang, Yi-Chen Chen, Yu-Rung Kao, Teh-Ying Chou, Chao-Chi Ho, Cheng-Wen Wu
Epidermal growth factor receptor (EGFR) mutations are found in lung adenocarcinomas leading to tumor cells proliferation and survival. EGFR tyrosine kinase inhibitors (TKIs) that block EGFR activity are effective therapeutics for EGFR-mutant lung adenocarcinoma patients, but TKI-resistance inevitably occurs. The YES-associated protein (YAP1) transcription coactivator has been implicated as an oncogene and is amplified in human cancers and provides tumor cells strong proliferation and survival cues. This study investigated the roles of YAP1 in lung adenocarcinoma by exploring its regulation and functions mediated by EGFR signaling...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29162840/whey-protein-concentrate-renders-mda-mb-231-cells-sensitive-to-rapamycin-by-altering-cellular-redox-state-and-activating-gsk3%C3%AE-mtor-signaling
#7
Shih-Hsuan Cheng, Yang-Ming Tseng, Szu-Hsien Wu, Shih-Meng Tsai, Li-Yu Tsai
Whey protein concentrate (WPC) is an amino acid-rich supplement that has been shown to increase cellular antioxidant capacity. Mammalian target of rapamycin (mTOR) is a crucial regulator of signaling in mammalian cells, and serves as a therapeutic target for triple-negative breast cancer (TNBC). This study was designed to investigate the effect of combining WPC with rapamycin on MDA-MB-231 human breast cancer cells. These cells were found to be insensitive to rapamycin and exhibited higher glutathione (GSH) and reactive oxygen species levels than non-tumorigenic MCF-10A cells...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29160690/correction-to-imprinted-nanovelcro-microchips-for-isolation-and-characterization-of-circulating-fetal-trophoblasts-toward-noninvasive-prenatal-diagnostics
#8
Shuang Hou, Jie-Fu Chen, Min Song, Yazhen Zhu, Yu Jen Jan, Szu Hao Chen, Tzu-Hua Weng, Dean-An Ling, Shang-Fu Chen, Tracy Ro, An-Jou Liang, Tom Lee, Helen Jin, Man Li, Lian Liu, Yu-Sheng Hsiao, Peilin Chen, Hsiao-Hua Yu, Ming-Song Tsai, Margareta D Pisarska, Angela Chen, Li-Ching Chen, Hsian-Rong Tseng
No abstract text is available yet for this article.
November 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/29159670/analysis-of-b-chromosome-nondisjunction-induced-by-the-r-x1-deficiency-in-maize
#9
Shih-Hsuan Tseng, Shu-Fen Peng, Ya-Ming Cheng
The maize B chromosome typically undergoes nondisjunction during the second microspore division. For normal A chromosomes, the r-X1 deficiency in maize can induce nondisjunction during the second megaspore and first microspore divisions. However, it is not known whether the r-X1 deficiency also induces nondisjunction of the maize B chromosome during these cell divisions. To answer this question, chromosome numbers were determined in the progeny of r-X1/R-r female parents carrying two B chromosomes. Some of the r-X1-lacking progeny (21...
November 20, 2017: Chromosome Research
https://www.readbyqxmd.com/read/29156047/immunopathogenesis-of-hepatitis-b-virus
#10
Tai-Chung Tseng, Li-Rung Huang
Chronic hepatitis B virus (HBV) infection is a global public health issue. There are >250 million people chronically infected with HBV, and these chronic carriers are at high risk of developing end-stage liver diseases and hepatocellular carcinoma. Patients with chronic hepatitis B (CHB) usually acquire the virus perinatally, while most patients infected during adulthood develop acute hepatitis B (AHB), which usually results in viral clearance. HBV infection is noncytopathic, and liver injury is mostly contributed by host immune responses...
November 16, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29155490/elimination-profile-of-triamcinolone-in-urine-following-oral-administration
#11
Ting-Ting Chen, Yi-Chun Tseng, Tai-Yuan Huang, Guo-Ping Chang-Chien, Mei-Chich Hsue
Triamcinolone (T) is a glucocorticoid commonly used to relieve inflammation and treat arthritis, severe allergies and asthma; however, it is banned by the World Anti-Doping Agency in competition for athletes when administered orally, intravenously, intramuscularly, or rectally. The minimum required performance limit (MRPL) for urinary T is 30 ng/mL. However, the data about the urinary excretion of T after oral administration is limited. We aimed to investigate the elimination profile and determine whether single-dose administration of T would cause a positive doping result...
November 20, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29152862/relational-interdependent-self-construal-and-gender-predicting-blood-pressure-reactivity-and-recovery-from-stress-in-early-adolescence
#12
Yoshito Kawabata, Wan-Ling Tseng, Dianna Murray-Close
This study investigated the association between relational-interdependent self-construals (relational interdependence) and blood pressure reactivity and recovery from two types of peer stressors (i.e., relational and instrumental) and gender as a moderator of this association. One hundred and ninety-six early adolescents (M = 10.11 years) reported their relational interdependence and participated in a laboratory stress protocol in which their systolic and diastolic blood pressures before, during, and after experiencing peer stressors were assessed...
December 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29149189/perioperative-body-weight-change-is-associated-with-in-hospital-mortality-in-cardiac-surgical-patients-with-postoperative-acute-kidney-injury
#13
Chih-Chung Shiao, Ya-Ting Huang, Tai-Shuan Lai, Tao-Min Huang, Jian-Jhong Wang, Chun-Te Huang, Pei-Chen Wu, Che-Hsiung Wu, I-Jung Tsai, Li-Jung Tseng, Chih-Hsien Wang, Tzong-Shinn Chu, Kwan-Dun Wu, Vin-Cent Wu
BACKGROUND: Postoperative acute kidney injury (AKI) is common following cardiac surgery (CS). Body weight (BW) may be an amenable variable by representing the summation of the nutritional and the fluid status. However, the predictive role of perioperative BW changes in CS patients with severe postoperative AKI is never explored. This study aimed to evaluate this association. METHODS: This study was conducted using a prospectively collected multicenter cohort, NSARF (National Taiwan University Hospital Study Group on Acute Renal Failure) database...
2017: PloS One
https://www.readbyqxmd.com/read/29147681/crimped-nanofibrous-biomaterials-mimic-microstructure-and-mechanics-of-native-tissue-and-alter-strain-transfer-to-cells
#14
Spencer E Szczesny, Tristan P Driscoll, Hsiao-Yun Tseng, Pang-Ching Liu, Su-Jin Heo, Robert L Mauck, Pen-Hsiu G Chao
To fully recapitulate tissue microstructure and mechanics, fiber crimping must exist within biomaterials used for tendon/ligament engineering. Existing crimped nanofibrous scaffolds produced via electrospinning are dense materials that prevent cellular infiltration into the scaffold interior. In this study, we used a sacrificial fiber population to increase the scaffold porosity and evaluated the effect on fiber crimping. We found that increasing scaffold porosity increased fiber crimping and ensured that the fibers properly uncrimped as the scaffolds were stretched by minimizing fiber-fiber interactions...
November 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29147117/colistin-resistance-of-pseudomonas-aeruginosa-isolated-from-snakes-in-taiwan
#15
Po-Yu Liu, Ling-Ling Weng, Shu-Ying Tseng, Chou-Chen Huang, Ching-Chang Cheng, Yan-Chiao Mao, Kwong-Chung Tung
This study included fifty-eight isolates of P. aeruginosa from the oral cavity of snakes that were recruited from clinical cases, captive and wild snakes. The minimum inhibitory concentrations (MICs) for the determination of susceptibility were identified by the broth microdilution method. Polymerase chain reaction (PCR) was employed to detect β-lactamases genes. With regard to antipseudomonal antibiotics, the lowest nonsusceptible rates were in aztreonam (15%), piperacillin/tazobactam (12%), and amikacin (9%)...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29146515/family-history-of-zoster-risk-of-developing-herpes-zoster
#16
Hung Fu Tseng, Margaret Chi, Peggy Hung, Rafael Harpaz, D Scott Schmid, Philip LaRussa, Lina S Sy, Yi Luo, Kimberly Holmquist, Harpreet Takhar, Steven J Jacobsen
BACKGROUND: Studies have investigated a possible association between family history of HZ and the occurrence of HZ. However, the results were inconclusive and susceptible to bias. We evaluated this association in an elderly population. METHODS: The matched case-control study conducted at Kaiser Permanente Southern California in 2012-2015 included 656 incident HZ patients ≥60 whose skin lesion tested positive for varicella zoster virus by polymerase chain reaction...
November 13, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29145834/identification-of-outliers-and-positive-deviants-for-healthcare-improvement-looking-for-high-performers-in-hypoglycemia-safety-in-patients-with-diabetes
#17
Brigid Wilson, Chin-Lin Tseng, Orysya Soroka, Leonard M Pogach, David C Aron
BACKGROUND: The study objectives were to determine: (1) how statistical outliers exhibiting low rates of diabetes overtreatment performed on a reciprocal measure - rates of diabetes undertreatment; and (2) the impact of different criteria on high performing outlier status. METHODS: The design was serial cross-sectional, using yearly Veterans Health Administration (VHA) administrative data (2009-2013). Our primary outcome measure was facility rate of HbA1c overtreatment of diabetes in patients at risk for hypoglycemia...
November 16, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29145781/analytical-high-resolution-electron-microscopy-reveals-organ-specific-nanoceria-bioprocessing
#18
Uschi M Graham, Robert A Yokel, Alan K Dozier, Lawrence Drummy, Krishnamurthy Mahalingam, Michael T Tseng, Eileen Birch, Joseph Fernback
This is the first utilization of advanced analytical electron microscopy methods, including high-resolution transmission electron microscopy, high-angle annular dark field scanning transmission electron microscopy, electron energy loss spectroscopy, and energy-dispersive X-ray spectroscopy mapping to characterize the organ-specific bioprocessing of a relatively inert nanomaterial (nanoceria). Liver and spleen samples from rats given a single intravenous infusion of nanoceria were obtained after prolonged (90 days) in vivo exposure...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/29145306/dynamic-noninvasive-markers-predict-hepatocellular-carcinoma-in-chronic-hepatitis-c-patients-without-sustained-virological-response-after-interferon-based-therapy-prioritize-who-needs-urgent-direct-acting-antiviral-agents
#19
Chao-Min Huang, Tsung-Hui Hu, Kuo-Chin Chang, Po-Lin Tseng, Sheng-Nan Lu, Chien-Hung Chen, Jing-Houng Wang, Chuan-Mo Lee, Ming-Chao Tsai, Ming-Tsung Lin, Yi-Hao Yen, Chao-Hung Hung, Chung-Lung Cho, Cheng-Kun Wu
Some patients with hepatitis C virus (HCV) infections who fail to achieve sustained virological responses (SVRs) after interferon (IFN) therapy do not develop hepatocellular carcinoma (HCC). Risk stratification of these patients may help identify those who would benefit most from treatment with direct-acting antivirals (DAAs).A total of 552 HCV-infected patients with non-SVR status were enrolled. Laboratory data before and after IFN treatment were analyzed to determine the relationship of changes in serum markers with development of HCC during the 7-year study period...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144506/soluble-p-selectin-promotes-retinal-ganglion-cell-survival-through-activation-of-nrf2-signaling-after-ischemia-injury
#20
Kishan Kapupara, Yao-Tseng Wen, Rong-Kung Tsai, Shun-Ping Huang
Retinal ischemic injuries play an important role in the pathogenesis of several eye disorders. Inflammation and oxidative stress are key players in ischemic injuries. Following retinal ischemia, vascular endothelial cells and leukocytes express several inflammatory adhesion receptors, such as selectins and cell adhesion molecules. P-selectin stimulates leukocyte recruitment to platelet aggregates and has an important role in vascular homeostasis and inflammatory leukocyte extravasation. Soluble P-selectin can be neuroprotective through competitive binding to the receptors of endogenous P-selectin molecules...
November 16, 2017: Cell Death & Disease
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