Carmen González-Gallardo, Juliana Martínez-Atienza, Beatriz Mataix, José Ignacio Muñoz-Ávila, J Daniel Martínez-Rodríguez, Santiago Medialdea, Antonio Ruiz-García, Antonio Lizana-Moreno, Salvador Arias-Santiago, Manuel de la Rosa-Fraile, Ingrid Garzon, Antonio Campos, Natividad Cuende, Miguel Alaminos, Miguel González-Andrades, Rosario Mata
OBJECTIVES: Corneal diseases are among the main causes of blindness, with approximately 4.6 and 23 million patients worldwide suffering from bilateral and unilateral corneal blindness, respectively. The standard treatment for severe corneal diseases is corneal transplantation. However, relevant disadvantages, particularly in high-risk conditions, have focused the attention on the search for alternatives. METHODS: We report interim findings of a phase I-II clinical study evaluating the safety and preliminary efficacy of a tissue-engineered corneal substitute composed of a nanostructured fibrin-agarose biocompatible scaffold combined with allogeneic corneal epithelial and stromal cells (NANOULCOR)...
March 27, 2023: Biomedicine & Pharmacotherapy