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topical Tacrolimus cornea

Alfonso Pastor-Clerigues, Adela Serrano, Javier Milara, Ezequiel Marti-Bonmati, Francisco J Lopez-Perez, Sara Garcia-Montanes, Joan Sanfeliu, Ana C Saval-Victoria, Julio Cortijo
PURPOSE: Tacrolimus ocular preparations are commonly employed in autoimmune or inflammatory ocular disorders. However, currently there are not yet approved ocular formulations. Tacrolimus ocular side effects have been reported in clinical use, so the evaluation of different pharmaceutical preparations is mandatory. In this study, the local corneal tolerance and safety profile of three common tacrolimus 0.03% pharmaceutical preparations were evaluated. MATERIAL AND METHODS: Corneal irritation and permeability of tacrolimus preparations were evaluated with the bovine corneal opacity and permeability (BCOP) test...
July 2016: Current Eye Research
Minawaer Abudou, Taixiang Wu, Jennifer R Evans, Xueyi Chen
BACKGROUND: Penetrating keratoplasty is a corneal transplantation procedure in which a full-thickness cornea from the host is replaced by a graft from a donor. The use of various immunosuppressants to prevent graft rejection, the most common cause of graft failure in the late postoperative period, is increasing. OBJECTIVES: To assess the effectiveness of immunosuppressants in the prophylaxis of corneal allograft rejection after high- and normal-risk keratoplasty...
2015: Cochrane Database of Systematic Reviews
Billie Beckwith-Cohen, David J Gasper, Ellison Bentley, Howard Gittelman, Angela E Ellis, Karen F Snowden, Barbara C Shock, Michael J Yabsley, Richard R Dubielzig
OBJECTIVE: To describe five cases of protozoal keratitis or conjunctivitis in dogs with chronic preexisting ocular surface disease treated with long-term immunosuppression. ANIMALS STUDIED: Five dogs that developed corneal or conjunctival mass lesions. PROCEDURES: The database of the Comparative Ocular Pathology Laboratory of Wisconsin was searched for canine cases diagnosed with corneal or conjunctival protozoal infection. Five cases were identified, and tissues were examined using routine and special histochemical stains: immunohistochemical labels for Neospora caninum, Toxoplasma gondii, and Leishmania spp...
May 2016: Veterinary Ophthalmology
Qi Li, Zhanrong Li, Weidong Zeng, Shumin Ge, Haoyang Lu, Chuanbin Wu, Li Ge, Dan Liang, Yuehong Xu
The objective of this study was to develop proniosome-derived niosomes for topical ophthalmic delivery of Tacrolimus (FK506). The FK506 loaded proniosomes containing poloxamer 188 and lecithin as surfactants, cholesterol as a stabilizer, and minimal amount of ethanol and trace water reconstituted to niosomes prior to use. The stability of FK506 loaded proniosomes was assessed, and the morphology, size, zeta potential, surface tension, and entrapment efficiency of the derived niosomes were characterized, indicating they were feasible for instillation in the eyes...
October 1, 2014: European Journal of Pharmaceutical Sciences
Natsuko Harada, Noriko Inada, Akiko Ishimori, Jun Shoji, Mitsuru Sawa
PURPOSE: A retrospective study for evaluating the clinical course of patients with vernal keratoconjunctivitis (VKC) treated with topical tacrolimus ophthalmic suspension 0.1% (Tacrolimus). SUBJECTS AND METHODS: Subjects were 30 patients (24 men and 6 women) with VKC who were treated with a combined therapy of Tacrolimus and antiallergic ophthalmic solution, and could be followed up for six months. The subjects were divided into two groups: 1. A conversion treatment group in which Tacrolimus was substituted for a steroid ophthalmic solution [21 patients; average age 14...
April 2014: Nippon Ganka Gakkai Zasshi
Pakit Vichyanond, Punchama Pacharn, Uwe Pleyer, Andrea Leonardi
Vernal keratoconjunctivitis (VKC) is an unusually severe sight-threatening allergic eye disease, occurring mainly in children. Conventional therapy for allergic conjunctivitis is generally not adequate for VKC. Pediatricians and allergists are often not familiar with the severe clinical symptoms and signs of VKC. As untreated VKC can lead to permanent visual loss, pediatric allergists should be aware of the management and therapeutic options for this disease to allow patients to enter clinical remission with the least side effects and sequelae...
June 2014: Pediatric Allergy and Immunology
Alexis J Dubin, Stefano Pizzirani, Gillian L Beamer
CASE DESCRIPTION: A 14-year-old 8.2-kg (18.04-lb) castrated male Cairn Terrier with chronic keratoconjunctivitis sicca in the left eye was evaluated because of severe blepharospasm and a black plaque of 3 weeks' duration. CLINICAL FINDINGS: Abnormalities of the left eye included a decreased Schirmer tear test value and the presence of a brownish-black plaque in the center of the cornea. The plaque was surrounded by fibrovascular tissue except at the medial aspect where there was mild malacia of the adjacent corneal stroma...
December 15, 2013: Journal of the American Veterinary Medical Association
Armando Silva-Cunha, Gisele Rodrigues da Silva, Whocely Victor de Castro, Sílvia Ligório Fialho
PURPOSE: Tacrolimus is a potent immunosuppressive agent with limited corneal penetration. Microemulsions can increase the drug solubility and enhance drug absorption in the eye. This work aimed to develop a tacrolimus microemulsion as well as to characterize and to evaluate its ocular tolerance and pharmacokinetics after topical application in rabbits. METHODS: The microemulsion was prepared by the titration with the cosurfactant technique and its physical-chemical parameters and stability were determined...
February 2014: Journal of Ocular Pharmacology and Therapeutics
Otavio A Magalhaes, Diane R Marinho, Sergio Kwitko
BACKGROUND/AIMS: The present study aims to identify the rate of rejection and safety of 0.03% tacrolimus eye drops associated with 1% prednisolone in a topical formulation, comparing them with the use of 1% prednisolone eye drops alone in patients with high-risk corneal transplantation. METHODS: Retrospective cohort study with 72 patients (72 eyes) who underwent more than one penetrating keratoplasty (PK) in the same eye or had severe chemical burn between 2004 and 2011 in the department of cornea and external disease of the Clinical Hospital of Porto Alegre, Brazil...
November 2013: British Journal of Ophthalmology
George D Kymionis, Nektarios E Klados, George A Kontadakis, Dimitrios G Mikropoulos
PURPOSE: To report 2 cases of superior limbic keratoconjunctivitis (SLK) treated with topical tacrolimus 0.03% ointment (Protopic; Fujisawa Healthcare). METHODS: A female patient aged 52 years and a male patient aged 21 years presented with SLK in both eyes. Both patients had previously received several treatments [such as topical steroids and lubrication, contact lenses, silicone punctal plugs, and vitamin A eye drops], with no improvement. Because of poor response to initial management, the authors started treatment with topical tacrolimus 0...
November 2013: Cornea
Pakit Vichyanond, Panida Kosrirukvongs
Vernal keratoconjunctivitis is a sight-threatening inflammatory disease of conjunctiva and cornea. It is frequently observed in young children with the onset usually occurring in the first decade of life. Mild cases of VKC tend to remit with nonspecific and supportive therapy. In contrast, severe cases are usually more protracted with remission/relapse occurring for a prolonged period of time. Although VKC is classified as an allergic eye condition, the role of allergens as an inciting factor is not clear. Pathogenesis of VKC involves roles for IgE, cytokines, chemokines, and inflammatory cells (T and B lymphocytes, mast cells, basophils, neutrophils, and eosinophils) with the release of their granular proteins, proliferation of fibroblasts, and laying down exuberant amounts of collagen fibers in the conjunctival tissue...
June 2013: Current Allergy and Asthma Reports
Dae Won Kim, Sung Ho Lee, Sae Kwang Ku, Soo Hyun Cho, Sung-Woo Cho, Ga Hyeon Yoon, Hyun Sook Hwang, Jinseu Park, Won Sik Eum, Oh-Shin Kwon, Soo Young Choi
FK506 binding protein 12 (FK506BP) belongs to a family of immunophilins, and is involved in multiple biological processes. However, the function of FK506BP in corneal disease remains unclear. In this study, we examined the protective effects on dry eye disease in a Botulinum toxin A (BTX-A) induced mouse model, using a cell-permeable PEP-1-FK506BP protein. PEP-1-FK506BP efficiently transduced into human corneal epithelial cells in a time- and dose-dependent manner, and remained stable in the cells for 48 h...
February 2013: BMB Reports
George D Kymionis, Vardhaman P Kankariya, Georgios A Kontadakis
PURPOSE: To report 2 cases of refractory phlyctenular keratoconjunctivitis treated with topical tacrolimus 0.03% ointment (Protopic). METHODS: Two white children, aged 5 years and 6 years, respectively, presented with refractory phlyctenular keratoconjunctivitis in 1 eye (left). Both were using corticosteroids and oral erythromycin at presentation with no relief. Examination revealed the presence of catarrhal corneal infiltrates and neovascularization associated with corneal thinning...
August 2012: Cornea
Jin Yuan, Jia-jie Zhai, Xi Huang, Shi-you Zhou, Jia-qi Chen
PURPOSE: The aim of this study was to investigate the sensitization, pharmacokinetics, and absorption of FK506 after corneal transplantation. METHODS: New Zealand albino rabbits were divided into normal and corneal transplantation groups. Each group was divided into 5 subgroups--saline, blank matrix, high-dose, medium-dose, and low-dose, respectively. There were 10 rabbits in each subgroup. One drop (25 μL) of FK506 was administered topically to both eyes of the rabbits 4 times daily for 30 days...
April 2012: Journal of Ocular Pharmacology and Therapeutics
Kristen J Gervais, Christopher G Pirie, Eric C Ledbetter, Stefano Pizzirani
We present a report of dendritic ulcerative keratitis in a 4-year old locally immunosuppressed dog suspected to result from acute primary canine herpesvirus-1 (CHV-1) infection. The dog was presented for evaluation of mild blepharospasm and conjunctival hyperemia in the right eye (OD) shortly after attending a public boarding facility. For approximately 3 months, the dog had been receiving topical prednisolone acetate 1.0% and tacrolimus 0.02% in both eyes (OU) q12h for treatment of follicular conjunctivitis...
March 2012: Veterinary Ophthalmology
Jennifer Dreyfus, Charles S Schobert, Richard R Dubielzig
OBJECTIVE: Canine corneal squamous cell carcinoma (SCC) is a rare tumor, with only eight cases previously published in the veterinary literature. The Comparative Ocular Pathology Lab of Wisconsin (COPLOW) has diagnosed 26 spontaneously occurring cases, 23 in the past 4 years. This retrospective study describes age and breed prevalence, concurrent therapy, biologic behavior, tumor size and character, and 6-month survival rates after diagnosis. RESULTS: A search of the COPLOW database identified 26 corneal SCC cases diagnosed from 1978 to 2008...
May 2011: Veterinary Ophthalmology
Burak Turgut, Mete Guler, Nusret Akpolat, Tamer Demır, Ulku Celıker
PURPOSE: To investigate the impact of tacrolimus on vascular endothelial growth factor (VEGF) in experimental corneal neovascularization (NV) immunohistochemically. MATERIAL AND METHODS: Five groups of seven Wistar albino rats were formed. A silver nitrate cauterization technique was used to induce corneal NV in the study groups, excluding Group 1 (Control Group). Rats in group 1 did not receive any treatment. Rats in group 2 (sham 1) were administered 1 ml of saline intraperitoneally once a day and those in group 3 (sham 2) received one drop of saline four times a day...
January 2011: Current Eye Research
Jin Yuan, Jia-jie Zhai, Jia-qi Chen, Cheng-tian Ye, Shi-you Zhou
PURPOSE: To investigate the stability of FK506 eye suspension and its pharmacokinetics in rabbit aqueous humor, as well as its distribution in eye tissues. METHODS: Sedimentation rate, flocculation value, redispersion time, rheological study, and accelerated experiment were determined for evaluating the stability of FK506 suspension. In a single-dose pharmacokinetic study, six rabbits were instilled a 25-microL drop of 0.05% FK506 suspension and aqueous humor samples were collected at different intervals after administration...
August 2009: Journal of Ocular Pharmacology and Therapeutics
Joanna C Norman, Jennifer L Urbanz, Sara T Calvarese
A 6-year-old, male neutered, German Shepherd dog presented for evaluation of a dark limbal mass OS. Based on the signalment and clinical findings, a presumptive diagnosis of limbal melanocytoma was made. Additionally, OU demonstrated corneal changes consistent with chronic superficial keratitis. Full thickness en bloc resection of the limbal mass was followed with reconstruction and grafting using both frozen cornea and bulbar conjunctiva. Nitrous oxide cryotherapy was utilized as an adjunctive modality for residual neoplastic cell destruction...
September 2008: Veterinary Ophthalmology
Eriko Fujita, Yoshinori Teramura, Toshifumi Shiraga, Shin-Ichi Yoshioka, Takafumi Iwatsubo, Akio Kawamura, Hidetaka Kamimura
PURPOSE: The aim of this study was to investigate the ocular distribution of tacrolimus (FK506) and absorption into the systemic circulation after a single or repeated topical instillation of FK506 ophthalmic suspension in male New Zealand white rabbits. METHODS: In the single instillation study (group 1), 29.1-34.8 microL of a 0.1, 0.3, and 1% suspension was administered to each of the 15 rabbits. In the repeated instillation study (group 2), 27.1-39.5 microL of a 0...
June 2008: Journal of Ocular Pharmacology and Therapeutics
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