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Colorectal metastes

Wilson Malta, Sílvia Pereira, Joana Gaspar, Ana C Silva, Moreira Costa
Colorectal carcinoma is common worldwide and its metastasis represents the main cause of mortality related to the disease. Inguinal metastization of this tumor has been considered almost impossible, owing to colon anatomy and its cranial lymphatic drainage. We report the case of a 63-year-old man submitted to laparoscopical sigmoid colectomy, due a sigmoid adenocarcinoma. During follow-up, a right inguinal lymphadenopathy with 25 mm was detected. Fine needle aspiration biopsy revealed that it was a colon adenocarcinoma metastasis, and thus the patient underwent an inguinal lymphadenectomy...
June 2017: Journal of Surgical Case Reports
Petra Eliasova, Michael Pinkas, Katarina Kolostova, Robert Gurlich, Vladimir Bobek
INTRODUCTION: Liquid biopsies are noninvasive tests using blood or body fluids to detect circulating tumor cells (CTCs) or the products of tumor cells, such as fragments of nucleic acids or proteins that are shed into biological fluids from primary tumor or its metastates. The analysis of published clinical studies provides coherent evidence that the presence of CTCs detected in peripheral blood is a strong prognostic factor in patients with colorectal carcinoma (CRC). The aim of the study was to implement size-based separation protocol of CTCs in CRC patients...
2017: Folia Histochemica et Cytobiologica
José Alexandre Ferreira, Ana Magalhães, Joana Gomes, Andreia Peixoto, Cristiana Gaiteiro, Elisabete Fernandes, Lúcio Lara Santos, Celso A Reis
Glycosylation is the most frequent and structurally complex posttranslational modification in cell-surface and secreted proteins. Glycans are major orchestrators of biological processes, namely, by controlling protein folding and key biological functions such as cell adhesion, migration, signaling and immune recognition. Altered glycosylation is considered a hallmark of malignant transformations that decisively contributes to disease outcome. This review comprehensively summarizes the main findings related with gastrointestinal cancers and the decisive impact of aberrant glycosylation on tumor biology toward more aggressive phenotypes...
February 28, 2017: Cancer Letters
A I G Lima, J Mota, S A V S Monteiro, R M S B Ferreira
MMP-9 activity is strongly related to cancer growth and metastization. This study aimed at assessing the inhibitory potential of the major seed protein fractions from eight selected legume species towards MMP-9 activity in colon carcinoma cells. Albumin and globulin fractions were screened for MMP-9 inhibitors, using a fluorometric assay and gelatin zymography. Their effect on HT29 cell proliferation and cell migration was tested, as well as on the corresponding intrinsic cellular MMP-9 activities. Seed proteins include potent inhibitors of MMP-9, particularly low molecular mass proteins...
April 15, 2016: Food Chemistry
R Alan Harris, Dorottya Nagy-Szakal, Richard Kellermayer
Metastable epialleles (MEs) are mammalian genomic loci where epigenetic patterning occurs before gastrulation in a stochastic fashion leading to systematic interindividual variation within one species. Importantly, periconceptual nutritional influences may modulate the establishment of epigenetic changes, such as DNA methylation at MEs. Based on these characteristics, we exploited Infinium HumanMethylation450 BeadChip kits in a 2-tissue parallel screen on peripheral blood leukocyte and colonic mucosal DNA from 10 children without identifiable large intestinal disease...
February 2013: Epigenetics: Official Journal of the DNA Methylation Society
A S Gonçalves, A S Macedo, E B Souto
Cancer is a complex disease which includes many pathologies featuring abnormal growth of healthy cells, invasion and metastization. Cellular uncontrolled growth increases the amount of abnormal cells, these cells reach the blood stream and other healthy tissues giving rise to secondary tumors. Even though great progresses have been made in understanding cancer aetiology and in the development of new anticancer drugs, cancer still remains one of the leading causes of death worldwide. Most common cancers include breast cancer, lung cancer, colorectal cancer and brain cancer...
December 2012: Clinical & Translational Oncology
R Iaffaioli, G Facchini, A Tortoriello, F Caponigro, G Gesue, A Finizio, N Dimartino, G Desena, B Antonelli, G Scaramellino, L Fei, M Santangelo, L Bucci
43 patients with metastatic colorectal Cancer pretreated with 5-fluorouracil-based chemotherapy received vinorelbine plus 5-fluorouracil plus folinic acid with the aim of evaluating vinorelbine activity in advanced colorectal cancer and its potential synergism with commonly used drugs. 9 partial responses were observed, for an;overall objective response rate of 20.9%. 20 additional patients had stable disease (46.5%). Median duration of response was 7 months. Median survival from the start of treatment was 6 months...
July 1995: Oncology Reports
Dirk Arnold, René Siewczynski, Stefan Kubicka, Ulrich Hacker, Hans-Joachim Schmoll
The choice of first-line treatment in metastatic colorectal carcinoma should basically depend on the clinical situation at the time and on the goals of treatment, because independent predictive factors have not yet been established. In patients with potentially resectable liver or lung metastases, the most active available therapy that might allow R0 resection should be given. At present this means a triple combination therapy, either with chemotherapy and a monoclonal antibody or the triple chemotherapy combination FOLFOXIRI...
2008: Onkologie
Rosine Guimbaud
Close to half of patients suffering from colorectal cancer develop metastases. Their natural prognosis is grim with a median survival of 6 to 7 months. Current treatment options rest on surgery and (or) chemotherapy. Complete surgical excision of the metastates is the treatment of choice as it permits cure rates and levels of long-term survival never attained with chemotherapy. It is only justified if it is complete; it must be systematically discussed with a specialised multidisciplinary team. However, it is possible only in a maximum of 10% of patients...
January 31, 2004: La Revue du Praticien
Lara Maria Pasetto, Elena Rossi, Silvio Monfardini
Colorectal adenocarcinoma ranks second as a cause of death due to cancer in the Western world. Liver metastases form the main cause of death in patients with colorectal cancer. Already at the time of the primary tumor, 15-25% of the patients present with liver metastases, while another 20% will develop these metastases following treatment of the colorectal primary. Without any treatment the median survival after the detection of liver metastases is approximately 9 months, depending on the extent of the disease at the time of diagnosis...
September 2003: Anticancer Research
L Solbiati
Since 1975-80, worldwide but mostly in Europe and Japan, sonography has become the imaging technique of choice for guiding percutaneous interventional procedures for diagnostic or therapeutic purposes. In the last 10 years, the most important advances in interventional ultrasound have occurred in therapeutic applications, fostering and facilitating the development of the so-called minimally-invasive techniques. Among all these new applications for the treatment of fluid collections, inflammatory diseases, benign and malignant tumors, the most recent dramatic advances have occurred in primary and secondary liver malignancies, which will be the focus of this review...
May 1998: European Journal of Radiology
E de Kant, I Heide, C Thiede, R Herrmann, C F Rochlitz
Overexpression of the multidrug resistance MDR1 gene is thought to contribute to drug resistance in non-responsive cancers like colorectal carcinoma. Little is known about the mechanisms by which expression of MDR1 is regulated in human tumours. However, there is growing evidence that regulation primarily takes place at the transcriptional level and that the process of tumour progression is related to activation of the MDR1 gene. Mutations in the p53 tumour-suppression gene occur in approximately 70% of colorectal cancers...
1996: Journal of Cancer Research and Clinical Oncology
S E Pinder, M Balsitis, I O Ellis, M Landon, R J Mayer, J Lowe
Alpha B-crystallin is a lens protein showing homology with small heat-shock proteins. We have previously demonstrated its expression in non-lenticular normal and diseased human tissues by immunostaining with a polyclonal antibody. In view of the expression seen in normal renal tubular epithelium, we have assessed the immunoreactivity of a variety of epithelial tumours, to determine the usefulness of alpha B-crystallin as a specific renal tumour marker. Carcinomas arising from tissues which normally express alpha B-crystallin, such as colo-rectal and thyroid carcinomas, showed a varying pattern and degree of immunoreactivity...
November 1994: Journal of Pathology
C P Verstijnen, J W Arends, P Moerkerk, B Schutte, E van der Linden, B Kuypers-Engelen, F T Bosman
In a series of 61 primary colorectal carcinomas, we attempted to determine which primary tumor characteristics correlated with the possibility to continuously maintain tumor cells in vitro or in vivo, and to what extent the characteristics of a primary tumor were maintained in vitro or as xenograft. Four continuous cell lines and 10 serially transplantable tumors were obtained. Only one cell line could be maintained both in vitro and in vivo. Tumors that had metastized and tumors in the proximal colon showed a higher success for in vivo and in vitro growth...
November 1988: Anticancer Research
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