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Hamed Ghasemi

Reza Naeimi, Fatemeh Safarpour, Mona Hashemian, Hamed Tashakorian, Seyed Raheleh Ahmadian, Manouchehr Ashrafpour, Maryam Ghasemi-Kasman
Curcumin has been introduced as effective anti-inflammatory agent in treatment of several inflammatory disorders. Despite the wide range pharmacological activities, clinical application of curcumin is restricted mainly due to the low water solubility of this substance. More recently, we could remarkably improve the aqueous solubility of curcumin by its encapsulation in chitosan-alginate-sodium tripolyphosphate nanoparticles (CS-ALG-STPP NPs). In this study, the anti-inflammatory and myelin protective effects of curcumin-loaded NPs were evaluated in lysolecithin (LPC)-induced focal demyelination model...
March 9, 2018: Neuroscience Letters
Arafeh Bigdeli, Forough Ghasemi, Hamed Golmohammadi, Samira Abbasi-Moayed, M Amin Farahmand Nejad, Nafiseh Fahimi-Kashani, Somayeh Jafarinejad, Maryam Shahrajabian, M Reza Hormozi-Nezhad
As in many other methods that have integrated nanoparticles (NPs), the chemical nose/tongue strategy has also progressed greatly since the entrance of NPs into this field. The fascinating tunable physicochemical properties of NPs have made them powerful candidates for array-based sensing platforms and have enabled the development of real-time, sensitive and portable systems that are able to target complex mixtures of analytes. In particular, the unique optical properties of NPs have a key role in providing promising array-based sensing approaches...
November 9, 2017: Nanoscale
Hamed Ghazavi, Seyed Javad Hoseini, Alireza Ebrahimzadeh-Bideskan, Baratali Mashkani, Soghra Mehri, Ahmad Ghorbani, Kayvan Sadri, Elahe Mahdipour, Faezeh Ghasemi, Fatemeh Forouzanfar, Azar Hoseini, Ali Reza Pasdar, Hamid Reza Sadeghnia, Majid Ghayour-Mobarhan
Stroke, as the second most common cause of death, imposes a great financial burden on both the individual and society. Mesenchymal stem cells from rodents have demonstrated efficacy in experimental animal models of stroke due to enhanced neurological recovery. Since FGF1 (fibroblast growth factor 1) displays neuroprotective properties, for the first time, we investigated the effect of acute intravenous administration of FGF1 gene transfected adipose-derived mesenchymal stem cell (AD-MSC(FGF1)) on transient experimental ischemic stroke in rats...
October 2017: Stem Cell Reviews
Seyed Ali Tabatabaei, Mohammad Soleimani, Reza Mirshahi, Mehdi Zandian, Hamed Ghasemi, Mohammad Naser Hashemian, Zahra Ghomi
PURPOSE: To report the results of a selective localized tenonplasty procedure based on findings of ocular surface fluorescein angiography (FA). METHODS: Six consecutive patients with severe chemical burns were included in this study. Using fluorescein angiogram images, patients underwent selective localized tenonplasty to cover the identified ischemic areas in FA. RESULTS: FA 1 week after surgery showed a perfused ocular surface in all eyes except for 1 quadrant of limbal ischemia in 1 eye...
August 2017: Cornea
Reza Karkhaneh, Masoud Nikbakht, Fatemeh Bazvand, Afshin Kalantary Oskouei, Hamed Ghasemi, Fariba Ghassemi
PURPOSE: To measure the submacular choroidal thickness in eyes with idiopathic macular hole (IMH) compared with unaffected fellow eyes and normal control eyes. METHODS: In this single institutional retrospective comparative case-control study, 34 consecutive patients with IMH were included and compared with 30 normal age- and sex-matched eyes that were planned to have cataract surgery. The included eyes were divided into 4 groups: 41 eyes with IMH (A), 23 unaffected fellow eyes (B), 30 normal eyes (C), and 12 vitrectomized IMH eyes (D)...
March 2017: Journal of Current Ophthalmology
Seyed Javad Hoseini, Hamed Ghazavi, Fatemeh Forouzanfar, Baratali Mashkani, Ahmad Ghorbani, Elahe Mahdipour, Faezeh Ghasemi, Hamid Reza Sadeghnia, Majid Ghayour-Mobarhan
The aim of this study was to investigate, for the first time, the effects of using adipose-derived mesenchymal stem cells (AD-MSCs) transfected with an episomal plasmid encoding fibroblast growth factor 1 (FGF1) (AD-MSCs(FGF1)), in providing the microenvironment required for angiogenic proliferation. The isolated rat AD-MSCs were positive for mesenchymal (CD29 and CD90) and negative for hematopoietic (CD34 and CD45) surface markers. Adipogenic and osteogenic differentiation of the AD-MSCs also occurred in the proper culture media...
May 2017: DNA and Cell Biology
Faezeh Ghasemi, Majid Ghayour-Mobarhan, Alireza Pasdar, Hamid Pourianfar, Mohammad Reza Aghasadeghi, Hamed Gouklani, Zahra Meshkat
BACKGROUND: The E2 glycoprotein is an important encoded hepatitis C virus (HCV) protein that contains three different variable regions. OBJECTIVES: The aim of the present study was to construct an HCV 1a/JFH1 chimeric virus by replacing the intergenotypic variable region (igVR) fragment of the highly variable region of the E2 gene of the Japanese Fulminant hepatitis genotype 2a JFH1 virus with a similar region of HCV genotype 1a. This chimera was produced as a model virus with the ability to be cultured...
October 2016: Hepatitis Monthly
Safieh Ebrahimi, Mina Hosseini, Faezeh Ghasemi, Soodabeh Shahidsales, Mina Maftouh, Hamed Akbarzade, Seyed Ali Reza Parizadeh, Seyed Mahdi Hassanian, Amir Avan
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a very poor prognosis, and excessive resistance to chemotherapy. MicroRNAs have been shown to play important roles in PDAC oncogenesis as they can act as both oncogenes and tumor suppressor molecules. Altered expression of specific microRNAs in PDAC has diagnostic and prognostic implications. There is growing body of evidence showing the important role of miR-486-5p and miR-938 for discrimination of PDAC patients from healthy subjects and those with chronic pancreatitis...
2016: Current Pharmaceutical Design
Marzieh Akrami, Ismaeil Ghasemi, Hamed Azizi, Mohammad Karrabi, Mohammad Seyedabadi
In this study, a new compatibilizer was synthesized to improve the compatibility of the poly(lactic acid)/thermoplastic starch blends. The compatibilizer was based on maleic anhydride grafted polyethylene glycol grafted starch (mPEG-g-St), and was characterized using Fourier transform infrared spectroscopy (FTIR), dynamic mechanical thermal analysis (DMTA) and back titration techniques. The results indicated successful accomplishment of the designed reactions and formation of a starch cored structure with many connections to m-PEG chains...
June 25, 2016: Carbohydrate Polymers
Hamed Shafaroodi, Saghar Barati, Mehdi Ghasemi, Ali Almasirad, Leila Moezi
There are reports indicating that diuretics including chlorothiazide, furosemide, ethacrynic acid, amiloride and bumetanide can have anticonvulsant properties. Intracellular acidification appears to be a mechanism for the anticonvulsant action of some diuretics. This study was conducted to investigate whether or not triamterene, a K(+)-sparing diuretic, can generate protection against seizures induced by intravenous or intraperitoneal pentylenetetrazole (PTZ) models. And to see if, triamterene can withstand maximal electroshock seizure (MES) in mice...
March 2016: Epilepsy Research
Mahdi Karimi, Navid Solati, Mohammad Amiri, Hamed Mirshekari, Elmira Mohamed, Mahdiar Taheri, Mahshid Hashemkhani, Ahad Saeidi, Mehrdad Asghari Estiar, Parnian Kiani, Amir Ghasemi, Seyed Masoud Moosavi Basri, Amir R Aref, Michael R Hamblin
INTRODUCTION: It is 23 years since carbon allotrope known as carbon nanotubes (CNT) was discovered by Iijima, who described them as "rolled graphite sheets inserted into each other". Since then, CNTs have been studied in nanoelectronic devices. However, CNTs also possess the versatility to act as drug- and gene-delivery vehicles. AREAS COVERED: This review covers the synthesis, purification and functionalization of CNTs. Arc discharge, laser ablation and chemical vapor deposition are the principle synthesis methods...
July 2015: Expert Opinion on Drug Delivery
Hamed Ghavimi, Mohammad Charkhpour, Saeed Ghasemi, Mehran Mesgari, Hadi Hamishehkar, Katayoun Hassanzadeh, Sanam Arami, Kambiz Hassanzadeh
BACKGROUND: Opioid induced neuroinflammation is shown to be implicated in opioid analgesic tolerance development. In the present study the effect of pioglitazone on morphine-induced tolerance and neuroinflammation in the cerebral cortex of the rat was investigated. MATERIALS AND METHODS: Various groups of rats received morphine (10mg/kg; ip) and vehicle (po), or morphine (10mg/kg) and pioglitazone (20 or 40 mg/kg; po) once a day for 17 days. In order to determine the possible involvement of PPAR-γ in the pioglitazone effect, one group of rats received PPAR-γ antagonist, GW-9662 (2mg/kg; sc), and pioglitazone (40 mg/kg) and morphine once daily for 17 days...
February 2015: Pharmacological Reports: PR
Abdollah Ghasemi Pirbalouti, Hamed Mirbagheri, Behzad Hamedi, Ebrahim Rahimi
OBJECTIVE: To evaluate the antibacterial activity of the essential oil of Myrtus communis (M. communis) L. against Erysipelothrix rhusiopathiae (E. rhusiopathiae) in vitro. METHODS: Wild populations of M. communis collected from Khuzestan and Lorestan provinces, Southwest Iran, were examined for antibacterial activity and chemical variability in leaves. The in vitro antibacterial activity against E. rhusiopathiae was performed by agar disc diffusion and micro-dilution assays...
May 2014: Asian Pacific Journal of Tropical Biomedicine
Mohammad Ahmadian, Sohyla Reshadat, Nader Yousefi, Seyed Hamed Mirhossieni, Mohammad Reza Zare, Seyed Ramin Ghasemi, Nader Rajabi Gilan, Razieh Khamutian, Ali Fatehizadeh
Due to complex composition of leachate, the comprehensive leachate treatment methods have been not demonstrated. Moreover, the improper management of leachate can lead to many environmental problems. The aim of this study was application of Fenton process for decreasing the major pollutants of landfill leachate on Kermanshah city. The leachate was collected from Kermanshah landfill site and treated by Fenton process. The effect of various parameters including solution pH, Fe(2+) and H2O2 dosage, Fe(2+)/H2O2 molar ratio, and reaction time was investigated...
2013: Journal of Environmental and Public Health
Hamed Reza Modayemzadeh, Mohsen Ghasemi Varnamkhasti, Hosein Zabolian
In this study, nanocrystalline Sn-doped In(2)O(3) (ITO) films were deposited by electron beam evaporation technique and were annealed in air atmosphere from 300°C to 500°C for 30 min. Then, the annealed ITO films in air at 450°C were reannealed in vacuum for 1 h at different temperatures from 300°C to 500°C. The effects of reannealing temperature on structural, electrical, and optical properties of the ITO films were investigated. Increasing reannealing temperature from 300°C to 500°C reduced sheet resistance of ITO thin films from 38 to 12(Ω/sq)...
May 20, 2013: Applied Optics
Saman Shafaat Talab, Azadeh Elmi, Hamed Emami, Behtash Ghazi Nezami, Solmaz Assa, Mehdi Ghasemi, Seyed Mohammad Tavangar, Ahmad Reza Dehpour
Delayed graft function secondary to ischemia/reperfusion injury has been shown to be associated with increased rate of allograft failure following kidney transplantation. Previously, we have shown that chronic lithium pretreatment protects kidney against ischemia/reperfusion injury. In the present study we aimed to examine the effects of acute lithium administration on the renal ischemia/reperfusion injury in rat. Ischemia/reperfusion injury was induced by clamping left renal pedicle for 60 min, two weeks after right nephrectomy...
April 15, 2012: European Journal of Pharmacology
Seyed Hamed Ghasemi, Mohammad-Reza Hantehzadeh, Jamshid Sabbaghzadeh, Davoud Dorranian, Majid Lafooti, Vahid Vatani, Reza Rezaei-Nasirabad, Atefeh Hemmati, Ali Asghar Amidian, Seyed Ali Alavian
A beam shaping technique that rearranges the beam for improving the beam symmetry and power density of a ten-bar high power diode laser stack is simulated considering a stripe mirror plate and a V-Stack mirror in the beam shaping system. In this technique, the beam of a high power diode laser stack is effectively coupled into a standard 550 μm core diameter and a NA=0.22 fiber. By this technique, compactness, higher efficiency, and lower cost production of the diode are possible.
June 20, 2011: Applied Optics
Ramak Roohipoor, Hamed Ghasemi, Fariba Ghassemi, Reza Karkhaneh, Mohammad Riazi-Esfahani, Mehdi Nili-Ahmadabadi
BACKGROUND: To evaluate the results of intravitreal bevacizumab in terms of regression of retinopathy of prematurity (ROP). METHODS: In this interventional case series, 12 eyes from January 2007 to December 2008 were included. Two groups of patients were considered. Group 1 included those ROP patients who did not respond to conventional laser therapy within 3 weeks or had some complications (hyphema or vitreous hemorrhage) after conventional laser therapy; intravitreal injection (0...
September 2011: Graefe's Archive for Clinical and Experimental Ophthalmology
Abbas Ghasemi, Mohammad Saberi, Mehdi Ghasemi, Hamed Shafaroodi, Leila Moezi, Arash Bahremand, Laleh Montaser-Kouhsari, Pouya Ziai, Ahmad Reza Dehpour
Although morphine has an anticonvulsant effect in several animal models of seizures, its potential clinical application in epilepsy may be hindered by its adverse effects like opioid tolerance. The present study evaluated the development of tolerance to the anticonvulsant effect of morphine in a model of clonic seizures induced with pentylenetetrazole (PTZ) in male Swiss mice. We also examined whether administration of either lithium chloride (LiCl) or magnesium chloride (MgCl(2)) was able to prevent the probable tolerance...
December 2010: Epilepsy & Behavior: E&B
Mehdi Ghasemi, Hamed Shafaroodi, Saeed Nazarbeiki, Hossein Meskar, Abbas Ghasemi, Arash Bahremand, Pouya Ziai, Ahmad Reza Dehpour
Although morphine has anticonvulsant effect in several animal models of seizure, its potential clinical application in epilepsy may be hindered by its adverse effects like the phenomenon of opioid tolerance. The present study evaluated the development of tolerance to the anticonvulsant effect of morphine in a model of clonic seizure induced by pentylenetetrazole (PTZ) in male Swiss mice. We also examined whether N-methyl-d-aspartate (NMDA) receptor/nitrergic system blockage was able to prevent the probable tolerance...
September 2010: Epilepsy Research
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