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Hamed Ghasemi

Faezeh Ghasemi, Majid Ghayour-Mobarhan, Alireza Pasdar, Hamid Pourianfar, Mohammad Reza Aghasadeghi, Hamed Gouklani, Zahra Meshkat
BACKGROUND: The E2 glycoprotein is an important encoded hepatitis C virus (HCV) protein that contains three different variable regions. OBJECTIVES: The aim of the present study was to construct an HCV 1a/JFH1 chimeric virus by replacing the intergenotypic variable region (igVR) fragment of the highly variable region of the E2 gene of the Japanese Fulminant hepatitis genotype 2a JFH1 virus with a similar region of HCV genotype 1a. This chimera was produced as a model virus with the ability to be cultured...
October 2016: Hepatitis Monthly
Safieh Ebrahimi, Faezeh Ghasemi, Seyed Mahdi Hassanian, Soodabeh Shahidsales, Ramin Mardani, Hamed Akbarzade, Seyed Mohammad Reza Parizadeh, Sharareh Gholamin, Anvar Soleimani, Majid Ghayour-Mobarhan, Amir Avan
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a very poor prognosis, and excessive resistance to chemotherapy. MicroRNAs have been shown to play important roles in PDAC oncogenesis as they can act as both oncogenes and tumor suppressor molecules. Altered expression of specific microRNAs in PDAC has diagnostic and prognostic implications. There is growing body of evidence showing the important role of miR-486-5p and miR-938 for discrimination of PDAC patients from healthy subjects and those with chronic pancreatitis...
August 16, 2016: Current Pharmaceutical Design
Marzieh Akrami, Ismaeil Ghasemi, Hamed Azizi, Mohammad Karrabi, Mohammad Seyedabadi
In this study, a new compatibilizer was synthesized to improve the compatibility of the poly(lactic acid)/thermoplastic starch blends. The compatibilizer was based on maleic anhydride grafted polyethylene glycol grafted starch (mPEG-g-St), and was characterized using Fourier transform infrared spectroscopy (FTIR), dynamic mechanical thermal analysis (DMTA) and back titration techniques. The results indicated successful accomplishment of the designed reactions and formation of a starch cored structure with many connections to m-PEG chains...
June 25, 2016: Carbohydrate Polymers
Hamed Shafaroodi, Saghar Barati, Mehdi Ghasemi, Ali Almasirad, Leila Moezi
There are reports indicating that diuretics including chlorothiazide, furosemide, ethacrynic acid, amiloride and bumetanide can have anticonvulsant properties. Intracellular acidification appears to be a mechanism for the anticonvulsant action of some diuretics. This study was conducted to investigate whether or not triamterene, a K(+)-sparing diuretic, can generate protection against seizures induced by intravenous or intraperitoneal pentylenetetrazole (PTZ) models. And to see if, triamterene can withstand maximal electroshock seizure (MES) in mice...
March 2016: Epilepsy Research
Mahdi Karimi, Navid Solati, Mohammad Amiri, Hamed Mirshekari, Elmira Mohamed, Mahdiar Taheri, Mahshid Hashemkhani, Ahad Saeidi, Mehrdad Asghari Estiar, Parnian Kiani, Amir Ghasemi, Seyed Masoud Moosavi Basri, Amir R Aref, Michael R Hamblin
INTRODUCTION: It is 23 years since carbon allotrope known as carbon nanotubes (CNT) was discovered by Iijima, who described them as "rolled graphite sheets inserted into each other". Since then, CNTs have been studied in nanoelectronic devices. However, CNTs also possess the versatility to act as drug- and gene-delivery vehicles. AREAS COVERED: This review covers the synthesis, purification and functionalization of CNTs. Arc discharge, laser ablation and chemical vapor deposition are the principle synthesis methods...
July 2015: Expert Opinion on Drug Delivery
Hamed Ghavimi, Mohammad Charkhpour, Saeed Ghasemi, Mehran Mesgari, Hadi Hamishehkar, Katayoun Hassanzadeh, Sanam Arami, Kambiz Hassanzadeh
BACKGROUND: Opioid induced neuroinflammation is shown to be implicated in opioid analgesic tolerance development. In the present study the effect of pioglitazone on morphine-induced tolerance and neuroinflammation in the cerebral cortex of the rat was investigated. MATERIALS AND METHODS: Various groups of rats received morphine (10mg/kg; ip) and vehicle (po), or morphine (10mg/kg) and pioglitazone (20 or 40 mg/kg; po) once a day for 17 days. In order to determine the possible involvement of PPAR-γ in the pioglitazone effect, one group of rats received PPAR-γ antagonist, GW-9662 (2mg/kg; sc), and pioglitazone (40 mg/kg) and morphine once daily for 17 days...
February 2015: Pharmacological Reports: PR
Abdollah Ghasemi Pirbalouti, Hamed Mirbagheri, Behzad Hamedi, Ebrahim Rahimi
OBJECTIVE: To evaluate the antibacterial activity of the essential oil of Myrtus communis (M. communis) L. against Erysipelothrix rhusiopathiae (E. rhusiopathiae) in vitro. METHODS: Wild populations of M. communis collected from Khuzestan and Lorestan provinces, Southwest Iran, were examined for antibacterial activity and chemical variability in leaves. The in vitro antibacterial activity against E. rhusiopathiae was performed by agar disc diffusion and micro-dilution assays...
May 2014: Asian Pacific Journal of Tropical Biomedicine
Mohammad Ahmadian, Sohyla Reshadat, Nader Yousefi, Seyed Hamed Mirhossieni, Mohammad Reza Zare, Seyed Ramin Ghasemi, Nader Rajabi Gilan, Razieh Khamutian, Ali Fatehizadeh
Due to complex composition of leachate, the comprehensive leachate treatment methods have been not demonstrated. Moreover, the improper management of leachate can lead to many environmental problems. The aim of this study was application of Fenton process for decreasing the major pollutants of landfill leachate on Kermanshah city. The leachate was collected from Kermanshah landfill site and treated by Fenton process. The effect of various parameters including solution pH, Fe(2+) and H2O2 dosage, Fe(2+)/H2O2 molar ratio, and reaction time was investigated...
2013: Journal of Environmental and Public Health
Hamed Reza Modayemzadeh, Mohsen Ghasemi Varnamkhasti, Hosein Zabolian
In this study, nanocrystalline Sn-doped In(2)O(3) (ITO) films were deposited by electron beam evaporation technique and were annealed in air atmosphere from 300°C to 500°C for 30 min. Then, the annealed ITO films in air at 450°C were reannealed in vacuum for 1 h at different temperatures from 300°C to 500°C. The effects of reannealing temperature on structural, electrical, and optical properties of the ITO films were investigated. Increasing reannealing temperature from 300°C to 500°C reduced sheet resistance of ITO thin films from 38 to 12(Ω/sq)...
May 20, 2013: Applied Optics
Saman Shafaat Talab, Azadeh Elmi, Hamed Emami, Behtash Ghazi Nezami, Solmaz Assa, Mehdi Ghasemi, Seyed Mohammad Tavangar, Ahmad Reza Dehpour
Delayed graft function secondary to ischemia/reperfusion injury has been shown to be associated with increased rate of allograft failure following kidney transplantation. Previously, we have shown that chronic lithium pretreatment protects kidney against ischemia/reperfusion injury. In the present study we aimed to examine the effects of acute lithium administration on the renal ischemia/reperfusion injury in rat. Ischemia/reperfusion injury was induced by clamping left renal pedicle for 60 min, two weeks after right nephrectomy...
April 15, 2012: European Journal of Pharmacology
Seyed Hamed Ghasemi, Mohammad-Reza Hantehzadeh, Jamshid Sabbaghzadeh, Davoud Dorranian, Majid Lafooti, Vahid Vatani, Reza Rezaei-Nasirabad, Atefeh Hemmati, Ali Asghar Amidian, Seyed Ali Alavian
A beam shaping technique that rearranges the beam for improving the beam symmetry and power density of a ten-bar high power diode laser stack is simulated considering a stripe mirror plate and a V-Stack mirror in the beam shaping system. In this technique, the beam of a high power diode laser stack is effectively coupled into a standard 550 μm core diameter and a NA=0.22 fiber. By this technique, compactness, higher efficiency, and lower cost production of the diode are possible.
June 20, 2011: Applied Optics
Ramak Roohipoor, Hamed Ghasemi, Fariba Ghassemi, Reza Karkhaneh, Mohammad Riazi-Esfahani, Mehdi Nili-Ahmadabadi
BACKGROUND: To evaluate the results of intravitreal bevacizumab in terms of regression of retinopathy of prematurity (ROP). METHODS: In this interventional case series, 12 eyes from January 2007 to December 2008 were included. Two groups of patients were considered. Group 1 included those ROP patients who did not respond to conventional laser therapy within 3 weeks or had some complications (hyphema or vitreous hemorrhage) after conventional laser therapy; intravitreal injection (0...
September 2011: Graefe's Archive for Clinical and Experimental Ophthalmology
Abbas Ghasemi, Mohammad Saberi, Mehdi Ghasemi, Hamed Shafaroodi, Leila Moezi, Arash Bahremand, Laleh Montaser-Kouhsari, Pouya Ziai, Ahmad Reza Dehpour
Although morphine has an anticonvulsant effect in several animal models of seizures, its potential clinical application in epilepsy may be hindered by its adverse effects like opioid tolerance. The present study evaluated the development of tolerance to the anticonvulsant effect of morphine in a model of clonic seizures induced with pentylenetetrazole (PTZ) in male Swiss mice. We also examined whether administration of either lithium chloride (LiCl) or magnesium chloride (MgCl(2)) was able to prevent the probable tolerance...
December 2010: Epilepsy & Behavior: E&B
Mehdi Ghasemi, Hamed Shafaroodi, Saeed Nazarbeiki, Hossein Meskar, Abbas Ghasemi, Arash Bahremand, Pouya Ziai, Ahmad Reza Dehpour
Although morphine has anticonvulsant effect in several animal models of seizure, its potential clinical application in epilepsy may be hindered by its adverse effects like the phenomenon of opioid tolerance. The present study evaluated the development of tolerance to the anticonvulsant effect of morphine in a model of clonic seizure induced by pentylenetetrazole (PTZ) in male Swiss mice. We also examined whether N-methyl-d-aspartate (NMDA) receptor/nitrergic system blockage was able to prevent the probable tolerance...
September 2010: Epilepsy Research
Mehdi Ghasemi, Hamed Shafaroodi, Saeed Nazarbeiki, Hossein Meskar, Pouria Heydarpour, Abbas Ghasemi, Saman Shafaat Talab, Pouya Ziai, Arash Bahremand, Ahmad Reza Dehpour
Although lithium is still a mainstay in the treatment of bipolar disorder, its underlying mechanisms of action have not been completely elucidated. Several studies have shown that lithium can also modulate seizure susceptibility in a variety of models. In the present study, using a model of clonic seizures induced with pentylenetetrazole (PTZ) in male Swiss mice, we investigated whether there is any interaction between lithium and either calcium channel blockers (CCBs: nifedipine, verapamil, and diltiazem) or N-methyl-D-aspartate (NMDA) receptor antagonists (ketamine and MK-801) in modulating seizure threshold...
July 2010: Epilepsy & Behavior: E&B
Hamed Shafaroodi, Farzad Ebrahimi, Leila Moezi, Mehrdad Hashemi, Yousef Doostar, Mehdi Ghasemi, Ahmad Reza Dehpour
BACKGROUND/AIMS: Acute cholestasis is associated with cardiovascular complications. The purpose of the present study was to investigate the effect of cholestasis on heart apoptosis and the involvement of nitric oxide (NO) and oxidative stress in the possible altered apoptosis of cholestatic hearts. METHODS: Cholestasis was induced by bile duct-ligation, and sham-operated mice served as controls. Three days after the surgery, heart tissues were evaluated for apoptosis and the level of malondialdehyde (MDA), and the activities of catalase (CAT), glutathione peroxidase (GSHPx) and superoxide dismutase (SOD) have been studied in cardiac tissues...
July 2010: Liver International: Official Journal of the International Association for the Study of the Liver
Mehdi Ghasemi, Hamed Shafaroodi, Ali Reza Karimollah, Taha Gholipour, Behtash Ghazi Nezami, Farzad Ebrahimi, Ahmad Reza Dehpour
Although there is evidence that diabetes affects seizure susceptibility, the underlying mechanism has not been completely understood. Several studies also suggest a pivotal role for K(ATP) channels in the seizure modulation. The aim of the present study was to evaluate the seizure threshold induced by pentylenetetrazole in diabetic mice at different times (3 days, 1-8 weeks) after induction of diabetes with streptozocin and to examine the possible role of ATP-sensitive potassium (K(ATP)) channels in this manner...
January 2010: Seizure: the Journal of the British Epilepsy Association
Farzad Ebrahimi, Hamed Shafaroodi, Shahrzad Asadi, Behtash Ghazi Nezami, Mehdi Ghasemi, Sina Rahimpour, Mehrdad Hashemi, Yousef Doostar, Ahmad Reza Dehpour
Oxidative stress plays a dominant role in the pathogenesis of cardiac cell apoptosis in diabetic patients. Sildenafil has been demonstrated to have antioxidant effects. In this study, the effects of sildenafil on diabetes-induced cardiac cell apoptosis and the antioxidant status of diabetic mouse hearts were investigated. Diabetic mice showed lower body weight gains and heart weights compared with control mice, and sildenafil treatment did not increase these parameters in diabetic mice. Although apoptotic rates, caspase-3 enzyme activity, and malondialdehyde levels were significantly higher in diabetic mouse hearts than in controls, they were reduced in diabetic mice after sildenafil treatment...
July 2009: Canadian Journal of Physiology and Pharmacology
Mehdi Ghasemi, Laleh Montaser-Kouhsari, Hamed Shafaroodi, Behtash Ghazi Nezami, Farzad Ebrahimi, Ahmad Reza Dehpour
OBJECTIVE: In this study, we evaluated the involvement of N-methyl-D-aspartate receptor (NMDAR)/nitric oxide (NO) system on the antidepressant-like effects of paroxetine in the mouse forced swimming test. METHOD: Swim sessions were conducted by placing mice in individual glass cylinders filled with water for 6 min. The duration of behavioral immobility during the last 4 min of the test was evaluated. RESULTS: Paroxetine (8 and 16 mg/kg, intraperitoneal [i...
October 2009: Psychopharmacology
Arash Bahremand, Sara Ebrahimi Nasrabady, Hamed Shafaroodi, Mehdi Ghasemi, Ahmad Reza Dehpour
Cannabinoid system plays a pivotal role in the seizure threshold modulation which is mainly mediated through activation of the cannabinoid CB(1) receptor. There is also several evidence of interaction between cannabinoid system and other neurotransmitters including nitric oxide (NO) system. Using model of clonic seizure induced by pentylenetetrazole (PTZ) in male NMRI mice, we investigated whether NO is involved in the effects of cannabinoids on the seizure threshold. Injection of the selective cannabinoid CB(1) agonist ACEA (2mg/kg, i...
April 2009: Epilepsy Research
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