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Ahmad Kheirkhah

Ahmad Kheirkhah, Vannarut Satitpitakul, Pedram Hamrah, Reza Dana
PURPOSE: To evaluate changes in corneal endothelial cell density over time in patients with dry eye disease (DED) and to correlate endothelial cell loss with corneal subbasal nerve density. METHODS: This retrospective study included 40 eyes of 20 patients with DED. Laser in vivo confocal microscopy had been performed in the central cornea of both eyes at an initial visit and repeated after a mean follow-up of 33.2 ± 10.2 months. The densities of corneal endothelial cells and subbasal nerves were measured in both visits and compared with 13 eyes of 13 normal age-matched controls...
November 2, 2016: Cornea
Janine Mikolajczak, Hanna Zimmermann, Ahmad Kheirkhah, Ella Maria Kadas, Timm Oberwahrenbrock, Rodrigo Muller, Aiai Ren, Joseph Kuchling, Holger Dietze, Harald Prüss, Friedemann Paul, Pedram Hamrah, Alexander U Brandt
BACKGROUND: Many studies in multiple sclerosis (MS) have investigated the retina. Little, however, is known about the effect of MS on the cornea, which is innervated by the trigeminal nerve. It is the site of neural-immune interaction with local dendritic cells reacting in response to environmental stimuli. OBJECTIVE: This study aims to investigate the effect of MS on corneal nerve fibres and dendritic cells in the subbasal nerve plexus using in vivo confocal microscopy (IVCM)...
November 3, 2016: Multiple Sclerosis: Clinical and Laboratory Research
Ahmad Kheirkhah, Yureeda Qazi, Michael A Arnoldner, Kunal Suri, Reza Dana
PURPOSE: To compare densities of corneal epithelial dendritic cells (DCs), corneal subbasal nerves, and conjunctival epithelial immune cells (EICs) between patients with dry eye disease (DED) with and without graft-versus-host disease (GVHD) using in vivo confocal microscopy (IVCM). METHODS: This study included 54 patients who had moderate to severe DED either associated with (n = 33) or without (n = 21) chronic GVHD. In addition to evaluating clinical parameters of DED, images obtained by laser-scanning IVCM of the central cornea and superior tarsal conjunctiva were analyzed to measure densities of corneal epithelial DCs, corneal subbasal nerves, and conjunctival EICs...
September 1, 2016: Investigative Ophthalmology & Visual Science
Hamid Safi, Ahmad Kheirkhah, Mirgholamreza Mahbod, Saber Molaei, Hassan Hashemi, Mahmoud Jabbarvand
PURPOSE: To investigate the correlations between clinical findings and histopathologic changes in eyes with pterygium. METHODS: This prospective study included 70 eyes with primary pterygia undergoing surgical excision. Prior to surgery, clinical features of the pterygia including extension over the cornea, redness, fleshiness (based on obscuration of the underlying episcleral vessels), and obliteration of the plica semilunaris were determined. Postoperatively, pterygium specimens were examined by hematoxylin-eosin and trichrome staining to evaluate histopathologic characteristics including vascular density, leukocytic infiltration, stromal elastosis, stromal fibrosis and subepithelial fibrosis...
April 2016: Journal of Ophthalmic & Vision Research
Alja Crnej, Ahmad Kheirkhah, Ai Ren, Andrew Mullins, Alenka Lavric, Kunal Suri, Reza Dana
PURPOSE: Although it has been known that patients' perspectives on their disease can significantly affect their level of functional disability as well as disease outcome, limited data are available on patients' perceptions of their dry eye disease (DED). The aim of this questionnaire-based study was to evaluate patients' perspectives on their DED. METHODS: This cross-sectional study included 91 patients with DED. In addition to clinical evaluation, all patients completed a questionnaire to evaluate their perspectives on their DED...
July 6, 2016: Ocular Surface
Roberto Annunziata, Ahmad Kheirkhah, Shruti Aggarwal, Pedram Hamrah, Emanuele Trucco
Recent clinical research has highlighted important links between a number of diseases and the tortuosity of curvilinear anatomical structures like corneal nerve fibres, suggesting that tortuosity changes might detect early stages of specific conditions. Currently, clinical studies are mainly based on subjective, visual assessment, with limited repeatability and inter-observer agreement. To address these problems, we propose a fully automated framework for image-level tortuosity estimation, consisting of a hybrid segmentation method and a highly adaptable, definition-free tortuosity estimation algorithm...
August 2016: Medical Image Analysis
Roberto Annunziata, Ahmad Kheirkhah, Shruti Aggarwal, Bernardo M Cavalcanti, Pedram Hamrah, Emanuele Trucco
PURPOSE: To assess the performance of a novel system for automated tortuosity estimation and interpretation. METHODS: A supervised strategy (driven by observers' grading) was employed to automatically identify the combination of tortuosity measures (i.e., tortuosity representation) leading to the best agreement with the observers. We investigated 18 tortuosity measures including curvature and density of inflection points, computed at multiple spatial scales. To leverage tortuosity interpretation, we propose the tortuosity plane (TP) onto which each image is mapped...
March 2016: Investigative Ophthalmology & Visual Science
Masood Naseripour, Hossein Aghaei, Ahad Sedaghat, Ahmad Kheirkhah, Ramin Jaberi, Zohreh Azma
PURPOSE: To evaluate the anatomical outcomes of corneal patch grafts in patients with progressive scleral necrosis secondary to plaque radiotherapy used for uveal malignant melanoma management. METHODS: In this case series, 4 patients with progressive scleral necrosis after Ru-106 plaque radiotherapy underwent corneal patch grafts with the anterior corneal button from Descemet stripping automated endothelial keratoplasty donor tissue to strengthen the sclera and to improve appearance of the eye...
April 2016: Cornea
Roberto Annunziata, Ahmad Kheirkhah, Pedram Hamrah, Emanuele Trucco
We propose a new approach to corneal nerve fibre centreline detection for in vivo confocal microscopy images. Relying on a combination of efficient hand-crafted features and learned filters, our method offers an excellent compromise between accuracy and running time. Unlike previous solutions using sparse coding to learn small filter banks, we employ K-means to efficiently learn the high amount of filters needed to cope with the multiple challenges involved, e.g., low contrast and resolution, non-uniform illumination, tortuosity and confounding non-target structures...
August 2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Ahmad Kheirkhah, Ujwala S Saboo, Anna Marmalidou, Reza Dana
PURPOSE: To evaluate the effect of frame size on the calculated corneal endothelial cell density (CECD) in images of laser scanning in vivo confocal microscopy (IVCM). METHODS: Forty-nine corneal endothelial images acquired by laser scanning IVCM (Heidelberg Retina Tomograph 3 with Rostock Corneal Module) with different endothelial cell densities were analyzed. In each image (160,000 μm), the CECD was calculated using the fixed-frame method by counting cells in the following frame sizes: 80,000 μm, 40,000 μm, 20,000 μm, 10,000 μm, 5000 μm, and 2500 μm...
March 2016: Cornea
Ahmad Kheirkhah, Raheleh Rahimi Darabad, Andrea Cruzat, Amir Reza Hajrasouliha, Deborah Witkin, Nadia Wong, Reza Dana, Pedram Hamrah
PURPOSE: To evaluate density and morphology of corneal epithelial immune dendritic cells (DCs) in different subtypes of dry eye disease (DED) using in vivo confocal microscopy (IVCM). METHODS: This retrospective study included 59 eyes of 37 patients with DED and 40 eyes of 20 age-matched healthy controls. Based on clinical tests, eyes with DED were categorized into two subtypes: aqueous-deficient (n = 35) and evaporative (n = 24). For all subjects, images of laser scanning in vivo confocal microscopy (IVCM) of the central cornea were analyzed for DC density and DC morphology (DC size, number of dendrites, and DC field)...
November 2015: Investigative Ophthalmology & Visual Science
Ahmad Kheirkhah, Rodrigo Muller, Janine Mikolajczak, Ai Ren, Ella Maria Kadas, Hanna Zimmermann, Harald Pruess, Friedemann Paul, Alexander U Brandt, Pedram Hamrah
PURPOSE: To evaluate whether the densities of corneal subbasal nerves and epithelial immune dendritiform cells (DCs) are comparable between a set of three representative standard images of in vivo confocal microscopy (IVCM) and the wide-field mapped composite IVCM images. METHODS: This prospective, cross-sectional, and masked study included 110 eyes of 58 patients seen in a neurology clinic who underwent laser-scanning IVCM (Heidelberg Retina Tomograph 3) of the central cornea...
September 2015: Investigative Ophthalmology & Visual Science
Neil Lagali, Enea Poletti, Dipika V Patel, Charles N J McGhee, Pedram Hamrah, Ahmad Kheirkhah, Mitra Tavakoli, Ioannis N Petropoulos, Rayaz A Malik, Tor Paaske Utheim, Andrey Zhivov, Oliver Stachs, Karen Falke, Sabine Peschel, Rudolf Guthoff, Cecilia Chao, Blanka Golebiowski, Fiona Stapleton, Alfredo Ruggeri
PURPOSE: We examined agreement among experts in the assessment of corneal subbasal nerve tortuosity. METHODS: Images of corneal subbasal nerves were obtained from investigators at seven sites (Auckland, Boston, Linköping, Manchester, Oslo, Rostock, and Sydney) using laser-scanning in vivo confocal microscopy. A set of 30 images was assembled and ordered by increasing tortuosity by 10 expert graders from the seven sites. In a first experiment, graders assessed tortuosity without a specific definition and performed grading three times, with at least 1 week between sessions...
August 2015: Investigative Ophthalmology & Visual Science
Shruti Aggarwal, Ahmad Kheirkhah, Bernardo M Cavalcanti, Andrea Cruzat, Clara Colon, Emma Brown, David Borsook, Harald Prüss, Pedram Hamrah
OBJECTIVE: Patients suffering from corneal neuropathy may present with photoallodynia; i.e., increased light sensitivity, frequently with a normal slit-lamp examination. This study aimed to evaluate the efficacy of autologous serum tears (AST) for treatment of severe photoallodynia in corneal neuropathy and to correlate clinical findings with corneal subbasal nerve alterations by in vivo confocal microscopy (IVCM). METHODS: Retrospective case control study with 16 patients with neuropathy-induced severe photoallodynia compared to 16 normal controls...
July 2015: Ocular Surface
Ahmad Kheirkhah, Ujwala S Saboo, Tulio B Abud, Thomas H Dohlman, Michael A Arnoldner, Pedram Hamrah, Reza Dana
PURPOSE: To evaluate corneal endothelial cell density (ECD) in patients with dry eye disease (DED) compared to an age-matched control group. DESIGN: Cross-sectional, controlled study. METHODS: This study included 90 eyes of 45 patients with moderate to severe DED (aged 53.7 ± 9.8 years) and 30 eyes of 15 normal controls (aged 50.7 ± 9.8 years). All subjects had a complete ophthalmic evaluation including symptom assessment using the Ocular Surface Disease Index (OSDI) and corneal fluorescein staining...
June 2015: American Journal of Ophthalmology
Ahmad Kheirkhah, Thomas H Dohlman, Francisco Amparo, Michael A Arnoldner, Arsia Jamali, Pedram Hamrah, Reza Dana
PURPOSE: To evaluate whether levels of corneal subbasal nerve fiber length (SNFL) in dry eye disease (DED) could prognosticate the level of improvement in signs and symptoms after treatment. DESIGN: Phase IV, double-masked, randomized clinical trial. PARTICIPANTS: Sixty patients with meibomian gland dysfunction-associated DED and 27 age-matched controls. METHODS: Patients with DED were randomized to receive topical artificial tears, loteprednol etabonate 0...
April 2015: Ophthalmology
Michael A Arnoldner, Ahmad Kheirkhah, Frederick A Jakobiec, Marlene L Durand, Pedram Hamrah
PURPOSE: To report a case of successful medical treatment with oral posaconazole in refractory fungal keratitis caused by Paecilomyces lilacinus. METHODS: Case report. RESULTS: A 57-year-old male, soft contact lens wearer presented with irritation, pain, photophobia, and reduced vision. Slit-lamp examination showed a large corneal epithelial defect with a peripheral infiltrate. The patient did not improve on fortified topical antibiotics. After the diagnosis of P...
July 2014: Cornea
Ali Tabatabaei, Narges Hasanlou, Ahmad Kheirkhah, Mohammadreza Mansouri, Houshang Faghihi, Hajar Jafari, Alireza Arefzadeh, Sasan Moghimi
PURPOSE: To compare the accuracy of 3 imaging modalities for preoperative evaluation of the posterior lens capsule in traumatic cataract. SETTING: Farabi Eye Hospital, Tehran, Iran. DESIGN: Case series. METHODS: The study comprised eyes with traumatic cataract opaque enough to prevent visualization of the posterior lens capsule on slitlamp examination. To detect posterior lens capsule rupture before surgery, imaging was performed with 20 MHz echography (Eye Cubed), anterior segment optical coherence tomography (AS-OCT) (Visante model 1000), and Scheimpflug imaging (Pentacam)...
July 2014: Journal of Cataract and Refractive Surgery
Hassan Hashemi, Alireza Yazdani-Abyaneh, Amirhushang Beheshtnejad, Mahmood Jabbarvand, Ahmad Kheirkhah, Seyed Reza Ghaffary
AIM: To evaluate the effect of implantation depth of Intacs microthin prescription inserts (Addition Technology Inc, Fremont, California) on visual and topographic outcomes in patients with post- laser-assisted in situ keratomileusis (LASIK) ectasias. SETTINGS AND DESIGN: Retrospective, observational case series. MATERIALS AND METHODS: In this case series, 16 eyes of 12 patients were evaluated. All cases were post-LASIK ectasia that had undergone intrastromal corneal ring segment (ICRS) implantation...
July 2013: Middle East African Journal of Ophthalmology
Hassan Hashemi, Mehdi Khabazkhoob, Ahmad Kheirkhah, Mohammad Hassan Emamian, Shiva Mehravaran, Mohammad Shariati, Akbar Fotouhi
BACKGROUND: To determine the prevalence of dry eye syndrome in the general 40- to 64-year-old population of Shahroud, Iran. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Through cluster sampling, 6311 people were selected and 5190 participated. Assessment of dry eye was done in a random subsample of 1008 people. METHODS: Subjective assessment for dry eye syndrome was performed using Ocular Surface Disease Index questionnaire...
April 2014: Clinical & Experimental Ophthalmology
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