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https://www.readbyqxmd.com/read/27866381/cardiac-magnetic-resonance-imaging-of-patent-ductus-arteriosus-in-three-dogs
#1
Youngjae Lee, Jaihyun Jung, Junyong Park, Jiyoon Jeong, Seokho Jeon, Sunyoung Park, Jinhwa Chang, Ji-Houn Kang, Chulhyun Lee, Dongwoo Chang
Patent ductus arteriosus (PDA) is the most common congenital cardiovascular disorder in dogs and requires an accurate diagnosis for an appropriate treatment. Cardiac MRI (cMRI) has been reported as a method for characterization of canine thoracic vasculature. However, to the authors' knowledge, no published studies describe evaluation of canine PDA through cMRI. Three dogs were selected for this exploratory study. Electrocardiogram gating and breath-hold techniques were performed using a 3T MR scanner. Both black blood imaging and bright blood cine acquisitions were performed...
November 20, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27830456/liraglutide-improves-cardiac-function-in-patients-with-type-2-diabetes-and-chronic-heart-failure
#2
F Arturi, E Succurro, S Miceli, C Cloro, M Ruffo, R Maio, M Perticone, G Sesti, F Perticone
PURPOSE: To compare the effect of liraglutide, sitagliptin and insulin glargine added to standard therapy on left ventricular function in post-ischemic type-2 diabetes mellitus patients. METHODS: We evaluated 32 type-2 diabetes mellitus Caucasians with history of post-ischemic chronic heart failure NYHA class II/III and/or left ventricular ejection fraction ≤45 %. Participants underwent laboratory determinations, electrocardiogram, echocardiogram, Minnesota Living with Heart Failure questionnaire and 6 min walking test at baseline and following 52 weeks treatment...
November 9, 2016: Endocrine
https://www.readbyqxmd.com/read/27823681/a-comparison-of-reduced-dose-prasugrel-and-standard-dose-clopidogrel-in-elderly-patients-with-acute-coronary-syndromes-undergoing-early-percutaneous-revascularization-design-and-rationale-of-the-randomized-elderly-acs-2-study
#3
Luca A Ferri, Nuccia Morici, Daniele Grosseto, Giovanni Tortorella, Irene Bossi, Paolo Sganzerla, Michele Cacucci, Girolamo Sibilio, Stefano Tondi, Anna Toso, Maurizio Ferrario, Nicola Gandolfo, Amelia Ravera, Matteo Mariani, Elena Corrada, Leonardo Di Ascenzo, Anna Sonia Petronio, Claudio Cavallini, Nadia Moffa, Stefano De Servi, Stefano Savonitto
BACKGROUND: Elderly patients display higher on clopidogrel platelet reactivity as compared with younger patients. Treatment with prasugrel 5mg has been shown to provide more predictable and homogenous antiplatelet effect, as compared with clopidogrel, suggesting the possibility of reducing ischemic events after an acute coronary syndrome (ACS) without increasing bleeding. STUDY DESIGN: The Elderly-ACS 2 study is a multicenter, randomized, parallel-group, open-label trial designed to demonstrate the superiority of a strategy of dual antiplatelet treatment using a reduced 5-mg daily dose of prasugrel over a standard strategy with a daily clopidogrel dose of 75mg in patients older than 74years with ACS (either ST- or non-ST-elevation myocardial infarction) undergoing early percutaneous revascularization...
November 2016: American Heart Journal
https://www.readbyqxmd.com/read/27766047/microrna-in-atherothromobosis-is-it-useful-as-a-disease-marker
#4
Satoshi Fujii, Tomonori Sugiura, Yasuaki Dohi, Nobuyuki Ohte
Atherosclerosis is one of the major causes of death. Data from animal experiments suggest that atherosclerosis involves an inflammatory process of the vascular wall under hyperlipidemia. Atherothrombosis can become a serious complication of atherosclerosis leading to acute cardiovascular events such as myocardial infarction and stroke. Clinical applications to use this knowledge remain scarce. The plasma levels of vascular endothelium-enriched microRNA (miRNAs) in patients with atherosclerotic vascular disease could serve as a disease marker...
2016: Thrombosis Journal
https://www.readbyqxmd.com/read/27618199/prolonged-corrected-qt-interval-as-a-predictor-of-clinical-outcome-in-acute-ischemic-stroke
#5
Milan Hromádka, Jitka Seidlerová, Vladimír Rohan, Jan Baxa, Jakub Šedivý, Daniel Rajdl, Ivan Ulč, Petr Ševčík, Jiří Polívka, Richard Rokyta
BACKGROUND: This study aimed to investigate changes of corrected QT (QTc) interval during acute ischemic stroke and its correlation with high-sensitivity troponin I (hsTnI), brain natriuretic peptide (BNP), neurological outcome, and 1-year mortality. METHODS: We registered electrocardiogram in 69 patients immediately after admission to the intensive care unit and then after 24 and 48 hours. Computed tomography was performed on admission to determine brain infarct size and localization...
September 8, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27583024/safety-of-long-term-exposure-to-abiraterone-acetate-in-patients-with-castration-resistant-prostate-cancer-and-concomitant-cardiovascular-risk-factors
#6
Elena Verzoni, Paolo Grassi, Raffaele Ratta, Monica Niger, Filippo De Braud, Riccardo Valdagni, Giuseppe Procopio
BACKGROUND: We aimed to evaluate the long-term safety profile of abiraterone in patients with metastatic castration-resistant prostate cancer (mCRPC) with controlled cardiovascular comorbidities or risk factors. METHODS: We retrospectively analysed the clinical charts of consecutive mCRPC patients with cardiac disorders/risk factors who had been treated with abiraterone 1000 mg once daily plus prednisone 5 mg twice daily for a median duration of 16 months at an oncology referral centre between April 2011 and July 2015...
September 2016: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/27548469/long-term-outcome-of-non-sustained-ventricular-tachycardia-in-structurally-normal-hearts
#7
Chin-Yu Lin, Shih-Lin Chang, Fa-Po Chung, Yun-Yu Chen, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Ta-Chuan Tuan, Tze-Fan Chao, Jo-Nan Liao, Yao-Ting Chang, Chung-Hsing Lin, Suresh Allamsetty, Rohit Walia, Abigail Louise D Te, Shinya Yamada, Shuo-Ju Chiang, Hsuan-Ming Tsao, Shih-Ann Chen
BACKGROUND: The impact of non-sustained ventricular tachycardia (NSVT) on the risk of thromboembolic event and clinical outcomes in patients without structural heart disease remains undetermined. This study aimed to evaluate the association between NSVT and clinical outcomes. METHODS: The study population of 5903 patients was culled from the "Registry of 24-hour ECG monitoring at Taipei Veterans General Hospital" (REMOTE database) between January 1, 2002 and December 31, 2004...
2016: PloS One
https://www.readbyqxmd.com/read/27508746/-op-1b-06-selective-heart-rate-reduction-with-ivabradine-increases-central-blood-pressure-in-stable-coronary-artery-disease
#8
S Rimoldi, F H Messerli, D Cerny, S Laurent, C Seiler
OBJECTIVE: Heart rate (HR) lowering by betablockade was shown to be beneficial after myocardial infarction. In contrast heart rate lowering with ivabradine was found to confer no benefits in two prospective randomized trials in patients with coronary artery disease (CAD). We hypothesised that this inefficacy could be in part related to ivabradine's effect on central (aortic) pressure. Aim of this study was to assess the HR lowering effect of ivabradine on invasively measured central blood pressure...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27470989/potential-cost-effectiveness-of-ambulatory-cardiac-rhythm-monitoring-after-cryptogenic-stroke
#9
Jean Hai Ein Yong, Kednapa Thavorn, Jeffrey S Hoch, Muhammad Mamdani, Kevin E Thorpe, Paul Dorian, Mike Sharma, Andreas Laupacis, David J Gladstone
BACKGROUND AND PURPOSE: Prolonged ambulatory ECG monitoring after cryptogenic stroke improves detection of covert atrial fibrillation, but its long-term cost-effectiveness is uncertain. METHODS: We estimated the cost-effectiveness of noninvasive ECG monitoring in patients aged ≥55 years after a recent cryptogenic stroke and negative 24-hour ECG. A Markov model used observed rates of atrial fibrillation detection and anticoagulation from a randomized controlled trial (EMBRACE) and the published literature to predict lifetime costs and effectiveness (ischemic strokes, hemorrhages, life-years, and quality-adjusted life-years [QALYs]) for 30-day ECG (primary analysis) and 7-day or 14-day ECG (secondary analysis), when compared with a repeat 24-hour ECG...
September 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27460129/using-extra-systoles-to-predict-fluid-responsiveness-in-cardiothoracic-critical-care-patients
#10
Simon Tilma Vistisen
Fluid responsiveness prediction is an unsettled matter for most critical care patients and new methods relying only on the continuous basic monitoring are desired. It was hypothesized that the post-ectopic beat, which is associated with increased preload, could be analyzed in relation to preceding sinus beats and that the change in cardiac performance (e.g. systolic blood pressure) at the post-ectopic beat could predict fluid responsiveness. Cardiothoracic critical care patients scheduled for a 500 ml volume expansion were observed...
July 26, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27403220/atrial-fibrillation-in-patients-with-transient-ischemic-attack-in-accordance-with-the-tissue-based-definition
#11
Björn Scheef, Mohamed Al-Khaled
BACKGROUND: Transient ischemic attack (TIA) management requires a cardiac evaluation with a Holter electrocardiogram (ECG), preferably a long-term (24 h) electrocardiogram (LT-ECG), to detect atrial fibrillation (AF), which places patients at higher risk of cerebrovascular events. The aim of this study was to determine the frequency of AF using ECG and LT-ECG in patients with tissue-based TIA. METHODS: During a three-year period (starting in 2011), all consecutive patients with tissue-based TIA (no evidence of infarction by brain imaging) were included and prospectively evaluated...
June 2016: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/27393863/invasive-strategy-in-non-st-segment-elevation-acute-coronary-syndrome-what-should-be-the-benchmark-target-in-the-real-world-patients-insights-from-blitz-4-quality-campaign
#12
Zoran Olivari, Alessandra Chinaglia, Lucio Gonzini, Giovanni Falsini, Annarita Pilleri, Serafina Valente, Gianserafino Gregori, Raffaele Rollo, Luigi My, Pietro Scrimieri, Tonino Lanzillo, Luigi Corrado, Maurizio Chiti, Elisa Picardi
AIMS: To define a benchmark target for an invasive strategy (IS) rate appropriate for performance assessment in intermediate-to-high risk non-ST-segment elevation acute coronary syndromes (NSTE-ACS). METHODS AND RESULTS: During the BLITZ-4 campaign, which aimed at improving the quality of care in 163 Italian coronary care units, 4923/5786 (85.1%) of consecutive patients admitted with NSTE-ACS with troponin elevation and/or dynamic ST-T changes on the electrocardiogram were managed with IS...
October 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27279848/cardiovascular-diseases-in-patients-65-years-and-younger-with-non-cardiogenic-stroke
#13
Anetta Lasek-Bal, Zbigniew Gąsior
INTRODUCTION: Approximately 10-15% of patients with stroke are under 65 years of age. The aim of the study was to determine types of stroke In people below 65. We analysed the incidence and types of associated cardiovascular diseases in patients with non-cardiogenic stroke. MATERIAL AND METHODS: In this prospective study patients (aged ≤ 65) with stroke underwent physical examination, computed tomography of the head, blood tests, electrocardiogram, echocardiography, and transcranial and carotid artery ultrasound...
June 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27275312/antiphospholipid-syndrome-a-case-report-of-pulmonary-thromboembolism-followed-with-acute-myocardial-infarction-in-patient-with-systemic-sclerosis
#14
Marija Vavlukis, Irina Kotlar, Emilija Chaparoska, Bekim Pocesta, Hristo Pejkov, Marjan Boshev, Sasko Kedev
AIM: We are presenting an uncommon case of pulmonary embolism, followed with an acute myocardial infarction, in a patient with progressive systemic sclerosis. CASE PRESENTATION: A female 40 years of age was admitted with signs of pulmonary embolism, confirmed with CT scan, which also reviled a thrombus in the right ventricle. The patient had medical history of systemic sclerosis since the age of 16 years. She suffered an ischemic stroke 6 years ago, but she was not taking any anticoagulant or antithrombotic medications ever since...
December 15, 2015: Open Access Maced J Med Sci
https://www.readbyqxmd.com/read/27265641/dynamic-changes-in-high-sensitivity-cardiac-troponin-i-are-associated-with-dynamic-changes-in-sum-absolute-qrst-integral-on-surface-electrocardiogram-in-acute-decompensated-heart-failure
#15
Larisa G Tereshchenko, Albert Feeny, Erica Shelton, Thomas Metkus, Andrew Stolbach, Ernest Mavunga, Shannon Putman, Frederick K Korley
BACKGROUND: A three-dimensional electrocardiographic (ECG) metric, the sum absolute QRST integral (SAI QRST), predicts ventricular arrhythmias in heart failure (HF) patients with implantable cardioverter defibrillator and mechanical response to cardiac resynchronization therapy. We hypothesized that there is an association between patient-specific changes in SAI QRST and myocardial injury as measured by high-sensitivity troponin I (hsTnI). METHODS: Sum absolute integral QRST on resting 12-lead ECG and hsTnI were measured simultaneously, every 3 hours, and during 12-hour observation period in a prospective cohort of emergency department patients (n = 398; mean age 57...
June 6, 2016: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/27240380/unobtrusive-estimation-of-cardiac-contractility-and-stroke-volume-changes-using-ballistocardiogram-measurements-on-a-high-bandwidth-force-plate
#16
Hazar Ashouri, Lara Orlandic, Omer T Inan
Unobtrusive and inexpensive technologies for monitoring the cardiovascular health of heart failure (HF) patients outside the clinic can potentially improve their continuity of care by enabling therapies to be adjusted dynamically based on the changing needs of the patients. Specifically, cardiac contractility and stroke volume (SV) are two key aspects of cardiovascular health that change significantly for HF patients as their condition worsens, yet these parameters are typically measured only in hospital/clinical settings, or with implantable sensors...
2016: Sensors
https://www.readbyqxmd.com/read/27213140/arrhythmias-and-electrocardiographic-changes-in-systolic-heart-failure
#17
Ashok Devkota, Ahmed Bakhit, Alix Dufresne, Aung Naing Oo, Premraj Parajuli, Saveena Manhas
BACKGROUND: Heart failure is a common condition that that leads to hospitalization. It is associated with various atrial and ventricular arrhythmias. AIM: The aim of this study is to find common arrhythmias and electrocardiographic changes in hospitalized patients who have systolic heart failure. MATERIALS AND METHODS: This is a retrospective study of medical records, and electrocardiograms (EKGs) of 157 patients admitted to our hospital who had systolic heart failure with ejection fraction (EF) <50% on echocardiogram...
April 2016: North American Journal of Medical Sciences
https://www.readbyqxmd.com/read/27199010/what-is-the-optimal-setting-for-a-continuous-flow-left-ventricular-assist-device-in-severe-mitral-regurgitation
#18
Noritsugu Naito, Takashi Nishimura, Yoshiaki Takewa, Satoru Kishimoto, Kazuma Date, Akihide Umeki, Masahiko Ando, Minoru Ono, Eisuke Tatsumi
Excessive left ventricular (LV) volume unloading can affect right ventricular (RV) function by causing a leftward shift of the interventricular septum in patients with mitral regurgitation (MR) receiving left ventricular assist device (LVAD) support. Optimal settings for the LVAD should be chosen to appropriately control the MR without causing RV dysfunction. In this study, we assessed the utility of our electrocardiogram-synchronized rotational speed (RS) modulation system along with a continuous-flow LVAD in a goat model of MR...
May 19, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27166580/characterization-of-an-investigative-safety-pharmacology-model-to-assess-comprehensive-cardiac-function-and-structure-in-chronically-instrumented-conscious-beagle-dogs
#19
Christopher P Regan, Gary L Stump, Theodore J Detwiler, Li Chen, Hillary K Regan, David B Gilberto, Joseph J DeGeorge, Frederick J Sannajust
INTRODUCTION: There has been an increasing need to conduct investigative safety pharmacology studies to complement regulatory-required studies, particularly as it applies to a comprehensive assessment of cardiovascular (CV) risk. METHODS: We describe refined methodology using a combination of telemetry and direct signal acquisition to record concomitant peripheral hemodynamics, ECG, and left ventricular (LV) structure (LV chamber size and LV wall thickness) and function, including LV pressure-volume (PV) loops to determine load independent measures of contractility (end systolic elastance, Ees, and preload recruitable stroke work, PRSW) in conscious beagle dogs...
September 2016: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/27042028/changes-of-deceleration-and-acceleration-capacity-of-heart-rate-in-patients-with-acute-hemispheric-ischemic-stroke
#20
Yan-Hong Xu, Xing-De Wang, Jia-Jun Yang, Li Zhou, Yong-Chao Pan
BACKGROUND AND PURPOSE: Autonomic dysfunction is common after stroke, which is correlated with unfavorable outcome. Phase-rectified signal averaging is a newly developed technique for assessing cardiac autonomic function, by detecting sympathetic and vagal nerve activity separately through calculating acceleration capacity (AC) and deceleration capacity (DC) of heart rate. In this study, we used this technique for the first time to investigate the cardiac autonomic function of patients with acute hemispheric ischemic stroke...
2016: Clinical Interventions in Aging
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