Yoshihiko Fujita, Hiromichi Matsuoka, Yasutaka Chiba, Junji Tsurutani, Takeshi Yoshida, Kiyohiro Sakai, Miki Nakura, Ryo Sakamoto, Chihiro Makimura, Yoichi Ohtake, Kaoru Tanaka, Hidetoshi Hayashi, Masayuki Takeda, Tatsuya Okuno, Naoki Takegawa, Koji Haratani, Takayuki Takahama, Junko Tanizaki, Atsuko Koyama, Kazuto Nishio, Kazuhiko Nakagawa
There have been few studies on predictive biomarkers that may be useful to select the most suitable opioids to optimize therapeutic efficacy in individual patients with cancer pain. We recently investigated the efficacy of morphine and oxycodone using single nucleotide polymorphisms (SNPs) of the catechol-O-methyltransferase ( COMT ) rs4680 gene as a biomarker (RELIEF study). To explore additional biomarkers that may enable the selection of an appropriate opioid for individual patients with cancer pain, three SNPs were examined: C-C motif chemokine ligand 11 ( CCL11 ; rs17809012), histamine N-methyltransferase ( HNMT ; rs1050891) and transient receptor potential V1 ( TRPV1 ; rs222749), which were screened from 74 pain-related SNPs...
August 2023: Oncology Letters