keyword
https://read.qxmd.com/read/38531338/first-in-vivo-experiment-with-pulmvalve-endobronchial-valve-feasibility-efficiency-and-safety
#1
JOURNAL ARTICLE
Jingwei Liu, Difei Chen, Yanhui Yu, Yu Deng, Ruijin Lu, Jing Zhang, Shiyue Li
INTRODUCTION: Endoscopic Lung Volume Reduction (ELVR) with endobronchial valves has been widely recognized for treating hyperinflation in advanced COPD and emphysema patients. The main challenges include the technical complexity of upper lobe implantation and the number of endobronchial valves required. These issues might be addressed by placing larger-diameter valves in the lobar bronchus. This study evaluated the feasibility, efficiency, and safety of the new valve PulmValve (model PV-13) in porcine models...
March 26, 2024: Respiration; International Review of Thoracic Diseases
https://read.qxmd.com/read/38521955/an-integrated-metabo-lipidomics-profile-of-induced-sputum-for-the-identification-of-novel-biomarkers-in-the-differential-diagnosis-of-asthma-and-copd
#2
JOURNAL ARTICLE
Serena Correnti, Mariaimmacolata Preianò, Fabia Gamboni, Daniel Stephenson, Corrado Pelaia, Girolamo Pelaia, Rocco Savino, Angelo D'Alessandro, Rosa Terracciano
BACKGROUND: Due to their complexity and to the presence of common clinical features, differentiation between asthma and chronic obstructive pulmonary disease (COPD) can be a challenging task, complicated in such cases also by asthma-COPD overlap syndrome. The distinct immune/inflammatory and structural substrates of COPD and asthma are responsible for significant differences in the responses to standard pharmacologic treatments. Therefore, an accurate diagnosis is of central relevance to assure the appropriate therapeutic intervention in order to achieve safe and effective patient care...
March 23, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38513223/long-term-exposure-to-air-pollution-and-risk-of-acute-lower-respiratory-infections-in-the-danish-nurse-cohort
#3
JOURNAL ARTICLE
Jiawei Zhang, Youn-Hee Lim, Rina So, Laust H Mortensen, George Maria Napolitano, Thomas Cole-Hunter, Stéphane Tuffier, Marie Bergmann, Matija Maric, Seyed Mahmood Taghavi Shahri, Jørgen Brandt, Matthias Ketzel, Steffen Loft, Zorana Jovanovic Andersen
RATIONALE: Air pollution is a major risk factor for chronic cardiorespiratory diseases, affecting both the immune and respiratory systems' functionality, while the epidemiological evidence on respiratory infections remains sparse. OBJECTIVE: We aimed to assess the association of long-term exposure to ambient air pollution with risk of developing new and recurrent ALRIs that characterized by persistently severe symptoms necessitating hospital contact, and identify the potential susceptible populations by socio-economic status (SES), smoking, physical activity status, overweight, and co-morbidity with chronic lung disease...
March 21, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38467956/ct-based-evaluation-of-the-shape-of-the-diaphragm-using-3d-slicer
#4
JOURNAL ARTICLE
Olivier Taton, Alain Van Muylem, Dimitri Leduc, Pierre Alain Gevenois
The diaphragm is the main inspiratory muscle and separates the thorax and the abdomen. In COPD, the evaluation of the diaphragm shape is clinically important, especially in the case of hyperinflation. However, delineating the diaphragm remains a challenge as it cannot be seen entirely on CT scans. Therefore, the lungs, ribs, sternum, and lumbar vertebrae are used as surrogate landmarks to delineate the diaphragm. We herein describe a CT-based method for evaluating the shape of the diaphragm using 3D Slicer-a free software that allows delineation of the diaphragm landmarks-in ten COPD patients...
March 11, 2024: J Imaging Inform Med
https://read.qxmd.com/read/38398384/the-impact-of-thermal-water-in-asthma-and-copd-a-systematic-review-according-to-the-prisma-statement
#5
REVIEW
Luigino Calzetta, Nicola Di Daniele, Alfredo Chetta, Marco Vitale, Shima Gholamalishahi, Mario Cazzola, Paola Rogliani
BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) are global health challenges leading to substantial morbidity and mortality. While existing guidelines emphasize evidence-based treatments, the potential therapeutic role of thermal water (TW) inhalation remains under-investigated. METHODS: This systematic review followed PRISMA-P guidelines and sought to evaluate the impact of TW in asthma and COPD. A thorough literature search, performed up to May 2023, encompassed in vitro, in vivo, randomized controlled trial (RCT), non-RCT, and observational studies...
February 14, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38379455/informed-development-of-a-multi-species-biofilm-in-chronic-obstructive-pulmonary-disease
#6
JOURNAL ARTICLE
Bryn Short, Christopher Delaney, William Johnston, Gary J Litherland, John C Lockhart, Craig Williams, William G Mackay, Gordon Ramage
Recent evidence indicates that microbial biofilm aggregates inhabit the lungs of COPD patients and actively contribute towards chronic colonization and repeat infections. However, there are no contextually relevant complex biofilm models for COPD research. In this study, a meta-analysis of the lung microbiome in COPD was used to inform development of an optimized biofilm model composed of genera highly associated with COPD. Bioinformatic analysis showed that although diversity matrices of COPD microbiomes were similar to healthy controls, and internal compositions made it possible to accurately differentiate between these cohorts (AUC = 0...
February 21, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38309095/eucalyptol-limonene-and-pinene-enteric-capsules-attenuate-airway-inflammation-and-obstruction-in-lipopolysaccharide-induced-chronic-bronchitis-rat-model-via-tlr4-signaling-inhibition
#7
JOURNAL ARTICLE
Xin-Yu Qiu, Li-Shan Yan, Jian-Ying Kang, Chun Yu Gu, Brian Chi-Yan Cheng, Yi-Wei Wang, Gan Luo, Yi Zhang
BACKGROUND: Chronic bronchitis (CB), a type of chronic obstructive pulmonary disease (COPD), poses a significant global health burden owing to its high morbidity and mortality rates. Eucalyptol, limonene and pinene enteric capsules (ELPs) are clinically used as expectorants to treat various respiratory diseases, including CB, but their acting mechanisms remain unclear. In this study, we investigated the anti-CB effects of ELP in a rat model of lipopolysaccharide (LPS)-induced CB. The molecular mechanisms underlying its inhibitory effects on airway inflammation were further explored in LPS-stimulated Beas-2B cells...
February 2, 2024: International Immunopharmacology
https://read.qxmd.com/read/38242945/transcriptomic-characterization-of-the-human-segmental-endotoxin-challenge-model
#8
JOURNAL ARTICLE
Christina Gress, Tobias Litzenburger, Ramona Schmid, Ke Xiao, Florian Heissig, Meike Muller, Abhya Gupta, Jens M Hohlfeld
Segmental instillation of lipopolysaccharide (LPS) by bronchoscopy safely induces transient airway inflammation in human lungs. This model enables investigation of pulmonary inflammatory mechanisms as well as pharmacodynamic analysis of investigational drugs. The aim of this work was to describe the transcriptomic profile of human segmental LPS challenge with contextualization to major respiratory diseases. Pre-challenge bronchoalveolar lavage (BAL) fluid and biopsies were sampled from 28 smoking, healthy participants, followed by segmental instillation of LPS and saline as control...
January 19, 2024: Scientific Reports
https://read.qxmd.com/read/38109838/cd146-deficiency-aggravates-chronic-obstructive-pulmonary-disease-via-the-increased-production-of-s100a9-and-mmp-9-in-macrophages
#9
JOURNAL ARTICLE
Jingxian Jiang, Min Wang, Weiyu Shen, Jingjing Wu, Qiyun Ma, Zhengxia Wang, Zhongqi Chen, Tao Bian, Ningfei Ji, Mao Huang, Mingshun Zhang
Chronic obstructive pulmonary disease (COPD) is a leading cause of global death. As a molecule beyond adhesion, CD146 is involved in COPD pathogenesis. However, the mechanisms of CD146 in COPD remain largely elusive. We hypothesized that CD146 regulates the production of matrix metalloproteinase-9 (MMP-9) in macrophages and thereby contributes to COPD. Here, we constructed a murine model of COPD using lipopolysaccharide (LPS) and porcine pancreatic elastase (PPE). In COPD-like mice, LPS and PPE decreased the pulmonary expression of CD146...
December 17, 2023: International Immunopharmacology
https://read.qxmd.com/read/37981453/a-novel-multimodal-framework-for-early-diagnosis-and-classification-of-copd-based-on-ct-scan-images-and-multivariate-pulmonary-respiratory-diseases
#10
JOURNAL ARTICLE
Santosh Kumar, Vijesh Bhagat, Prakash Sahu, Mithliesh Kumar Chaube, Ajoy Kumar Behera, Mohsen Guizani, Raffaele Gravina, Michele Di Dio, Giancarlo Fortino, Edward Curry, Saeed Hamood Alsamhi
BACKGROUND AND OBJECTIVE: Chronic Obstructive Pulmonary Disease (COPD) is one of the world's worst diseases; its early diagnosis using existing methods like statistical machine learning techniques, medical diagnostic tools, conventional medical procedures, and other methods is challenging due to misclassification results of COPD diagnosis and takes a long time to perform accurate prediction. Due to the severe consequences of COPD, detection and accurate diagnosis of COPD at an early stage is essential...
November 10, 2023: Computer Methods and Programs in Biomedicine
https://read.qxmd.com/read/37884207/development-of-lung-tissue-models-and-their-applications
#11
REVIEW
Nalinrat Petpiroon, Woranan Netkueakul, Kanokwan Sukrak, Chen Wang, Yin Liang, Mengxue Wang, Yun Liu, Qiang Li, Rumaisa Kamran, Keiji Naruse, Sasitorn Aueviriyavit, Ken Takahashi
The lungs are important organs that play a critical role in the development of specific diseases, as well as responding to the effects of drugs, chemicals, and environmental pollutants. Due to the ethical concerns around animal testing, alternative methods have been sought which are more time-effective, do not pose ethical issues for animals, do not involve species differences, and provide easy investigation of the pathobiology of lung diseases. Several national and international organizations are working to accelerate the development and implementation of structurally and functionally complex tissue models as alternatives to animal testing, particularly for the lung...
October 24, 2023: Life Sciences
https://read.qxmd.com/read/37864243/development-and-evaluation-of-the-rural-and-northern-community-focused-model-of-copd-care-rancom
#12
JOURNAL ARTICLE
Shannon Freeman, Laura Peach, Christopher Ross, Kathy Marchal, Anthon Meyer, Kelly Skinner
BACKGROUND: The prevalence of COPD continues to rise. To address the challenges to provide high quality COPD care in rural and northern communities, leaders in one rural and northern community in Western Canada sought to change the culture of COPD screening and care. Recognizing effective assessment, diagnosis, and treatment for patients with COPD are crucial to improve outcomes, a program was developed between 2012 and 2021 to enhance primary care for COPD patients. METHODS: A process evaluation was undertaken to assess program development, implementation, mechanisms of impact, and context of COPD program...
October 20, 2023: BMC Pulmonary Medicine
https://read.qxmd.com/read/37847710/a-potent-mapk13-14-inhibitor-prevents-airway-inflammation-and-mucus-production
#13
JOURNAL ARTICLE
Shamus P Keeler, Kangyun Wu, Yong Zhang, Dailing Mao, Ming Li, Courtney A Iberg, Stephen R Austin, Samuel A Glaser, Jennifer Yantis, Stephanie Podgorny, Steven L Brody, Joshua R Chartock, Zhenfu Han, Derek E Byers, Arthur G Romero, Michael J Holtzman
Common respiratory diseases continue to represent a major public health problem, and much of the morbidity and mortality is due to airway inflammation and mucus production. Previous studies indicated a role for mitogen-activated protein kinase 14 (MAPK14) in this type of disease, but clinical trials are unsuccessful to date. Our previous work identified a related but distinct kinase known as MAPK13 that is activated in respiratory airway diseases and is required for mucus production in human cell-culture models...
October 17, 2023: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/37562641/the-effect-of-bradykinin-1-receptor-antagonist-bi-1026706-on-pulmonary-inflammation-after-segmental-lipopolysaccharide-challenge-in-healthy-smokers
#14
JOURNAL ARTICLE
Christina Gress, Jens Vogel-Claussen, Philipp Badorrek, Meike Müller, Kathrin Hohl, Marilisa Konietzke, Tobias Litzenburger, Wolfgang Seibold, Abhya Gupta, Jens M Hohlfeld
BACKGROUND: Bradykinin 1 receptor (B1R) signalling pathways may be involved in the inflammatory pathophysiology of chronic obstructive pulmonary disease (COPD). B1R signalling is induced by inflammatory stimuli or tissue injury and leads to activation and increased migration of pro-inflammatory cells. Lipopolysaccharide (LPS) lung challenge in man is an experimental method of exploring inflammation in the lung whereby interference in these pathways can help to assess pharmacologic interventions in COPD...
August 8, 2023: Pulmonary Pharmacology & Therapeutics
https://read.qxmd.com/read/37546739/microbial-community-organization-designates-distinct-pulmonary-exacerbation-types-and-predicts-treatment-outcome-in-cystic-fibrosis
#15
Stefanie Widder, Kristopher Opron, Lisa A Carmody, Linda M Kalikin, Lindsay J Caverly, John J LiPuma
Polymicrobial infection of the airways is a hallmark of obstructive lung diseases such as cystic fibrosis (CF), non-CF bronchiectasis, and chronic obstructive pulmonary disease (COPD). Intermittent pulmonary exacerbations (PEx) in these conditions are associated with lung function decline and higher mortality rates. An understanding of the microbial underpinnings of PEx is challenged by high inter-patient variability in airway microbial community profiles. We analyzed 880 near-daily CF sputum samples and developed non-standard microbiome descriptors to model community reorganization prior and during 18 PEx...
July 25, 2023: bioRxiv
https://read.qxmd.com/read/37353335/pulmonary-rehabilitation-in-persons-with-copd
#16
JOURNAL ARTICLE
Chris Garvey
Pulmonary rehabilitation (PR) is a high-value intervention for persons with COPD and other chronic lung diseases. It is associated with improvement in exercise capacity, dyspnea, health-related quality of life, and depression as well as a reduction in hospitalization and improved survival when PR follows COPD-related hospitalizations. PR is underused in the United States and other countries despite strong evidence of both clinical effectiveness and cost-effectiveness. Additional challenges include a lack of equitable reimbursement and poor access, particularly in rural settings...
July 2023: Respiratory Care
https://read.qxmd.com/read/37305790/mobile-heath-applications-for-self-management-in-chronic-lung-disease-a-systematic-review
#17
REVIEW
Shirley Quach, Wade Michaelchuk, Adam Benoit, Ana Oliveira, Tara L Packham, Roger Goldstein, Dina Brooks
UNLABELLED: Integration of mobile health (mHealth) applications (apps) into chronic lung disease management is becoming increasingly popular. MHealth apps may support adoption of self-management behaviors to assist people in symptoms control and quality of life enhancement. However, mHealth apps' designs, features, and content are inconsistently reported, making it difficult to determine which were the effective components. Therefore, this review aims to summarize the characteristics and features of published mHealth apps for chronic lung diseases...
2023: Network Modeling and Analysis in Health Informatics and Bioinformatics
https://read.qxmd.com/read/37304093/critical-air-pollutant-assessments-and-health-effects-attributed-to-pm-2-5-during-and-after-covid-19-lockdowns-in-iran-application-of-airq-models
#18
JOURNAL ARTICLE
Safiye Ghobakhloo, Amir Hossein Khoshakhlagh, Gholam Reza Mostafaii, Kai-Jen Chuang, Agnieszka Gruszecka-Kosowska, Pariya Hosseinnia
OBJECTIVES: The aim of this study was to evaluate changes in air quality index (AQI) values before, during, and after lockdown, as well as to evaluate the number of hospitalizations due to respiratory and cardiovascular diseases attributed to atmospheric PM2.5 pollution in Semnan, Iran in the period from 2019 to 2021 during the COVID-19 pandemic. METHODS: Daily air quality records were obtained from the global air quality index project and the US Environmental Protection Administration (EPA)...
2023: Frontiers in Public Health
https://read.qxmd.com/read/37153221/machine-learning-for-screening-of-at-risk-mild-and-moderate-copd-patients-at-risk-of-fev-1-decline-results-from-copdgene-and-spiromics
#19
JOURNAL ARTICLE
Jennifer M Wang, Wassim W Labaki, Susan Murray, Fernando J Martinez, Jeffrey L Curtis, Eric A Hoffman, Sundaresh Ram, Alexander J Bell, Craig J Galban, MeiLan K Han, Charles Hatt
Purpose: The purpose of this study was to train and validate machine learning models for predicting rapid decline of forced expiratory volume in 1 s (FEV1 ) in individuals with a smoking history at-risk-for chronic obstructive pulmonary disease (COPD), Global Initiative for Chronic Obstructive Lung Disease (GOLD 0), or with mild-to-moderate (GOLD 1-2) COPD. We trained multiple models to predict rapid FEV1 decline using demographic, clinical and radiologic biomarker data. Training and internal validation data were obtained from the COPDGene study and prediction models were validated against the SPIROMICS cohort...
2023: Frontiers in Physiology
https://read.qxmd.com/read/37139140/non-invasive-detection-of-severe-ph-in-lung-disease-using-magnetic-resonance-imaging
#20
JOURNAL ARTICLE
Dheyaa Alkhanfar, Krit Dwivedi, Faisal Alandejani, Yousef Shahin, Samer Alabed, Chris Johns, Pankaj Garg, A A Roger Thompson, Alexander M K Rothman, Abdul Hameed, Athanasios Charalampopoulos, Jim M Wild, Robin Condliffe, David G Kiely, Andrew J Swift
INTRODUCTION: Severe pulmonary hypertension (mean pulmonary artery pressure ≥35 mmHg) in chronic lung disease (PH-CLD) is associated with high mortality and morbidity. Data suggesting potential response to vasodilator therapy in patients with PH-CLD is emerging. The current diagnostic strategy utilises transthoracic Echocardiography (TTE), which can be technically challenging in some patients with advanced CLD. The aim of this study was to evaluate the diagnostic role of MRI models to diagnose severe PH in CLD...
2023: Frontiers in Cardiovascular Medicine
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