Nicolaus F Debatin, Elena Bady, Tim Mandelkow, Zhihao Huang, Magalie C J Lurati, Jonas B Raedler, Jan H Müller, Eik Vettorazzi, Henning Plage, Henrik Samtleben, Tobias Klatte, Sebastian Hofbauer, Sefer Elezkurtaj, Kira Furlano, Sarah Weinberger, Paul Giacomo Bruch, David Horst, Florian Roßner, Simon Schallenberg, Andreas H Marx, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten H Ecke, Steffen Hallmann, Stefan Koch, Nico Adamini, Maximilian Lennartz, Sarah Minner, Ronald Simon, Guido Sauter, Henrik Zecha, Thorsten Schlomm, Niclas C Blessin
BACKGROUND: Quantity and the spatial relationship of specific immune cell types can provide prognostic information in bladder cancer. OBJECTIVE: To characterize the spatial interplay and prognostic role of different immune cell subpopulations in bladder cancer. DESIGN, SETTING, AND PARTICIPANTS: A total of 2463 urothelial bladder carcinomas were immunostained with 21 antibodies using BLEACH&STAIN multiplex fluorescence immunohistochemistry in a tissue microarray format and analyzed using a framework of neuronal networks for an image analysis...
February 20, 2024: European Urology