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https://www.readbyqxmd.com/read/28905758/re-testosterone-treatment-and-coronary-artery-plaque-volume-in-older%C3%A2-men-with-low-testosterone
#1
Allen D Seftel
No abstract text is available yet for this article.
October 2017: Journal of Urology
https://www.readbyqxmd.com/read/28905168/the-usefulness-of-testosterone-administration-in-identifying-false-positive-elevation-of-serum-human-chorionic-gonadotropin-in-patients-with-germ-cell-tumor
#2
Akitoshi Takizawa, Koji Kawai, Takashi Kawahara, Takahiro Kojima, Satoru Maruyama, Nobuo Shinohara, Shusuke Akamatsu, Tomomi Kamba, Terukazu Nakamura, Osamu Ukimura, Ryosuke Jikuya, Takeshi Kishida, Kenichi Kakimoto, Kazuo Nishimura, Toru Harabayashi, Satoshi Nagamori, Shinichi Yamashita, Yoichi Arai, Yoshitomo Sawada, Noritoshi Sekido, Hidefumi Kinoshita, Tadashi Matsuda, Tohru Nakagawa, Yukio Homma, Hiroyuki Nishiyama
OBJECTIVE: The pituitary production of human chorionic gonadotropin (hCG) can cause false-positive results during or after germ cell tumor (GCT) treatment. Because hypogonadism leads to pituitary hCG production, testosterone administration test (TAT) has been recommended for pituitary hCG diagnosis. However, little is known about its efficacy for the discrimination of pituitary hCG as detected by currently used hCG assays in treatment of GCT. We conducted a retrospective multicenter study to determine the usefulness of TAT...
September 13, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28901866/a-novel-potential-reproductive-effects-of-pterocarpus-marsupium-methanolic-extract-on-testosterone-propionate-induced-polycystic-ovary-syndrome-in-female-albino-rats
#3
Aruna Lingappa Hugar, Amarvani P Kanjikar, Ramesh L Londonkar
Objective To investigate potential reproductive effects of Pterocarpus marsupium methanolic extract on testosterone propionate induced Polycystic Ovarian Syndrome (PCOS) in female albino rats. Methodology PCOS was induced in female albino rats by daily injecting testosterone propionate for 15 days intraperitoneally. Animals are divided into five groups with six rats per group. Group 1: Control group received olive oil, Group 2: Testosterone propionate+natural recovery, Group 3: Testosterone propionate + a dose of clomiphene citrate (standard), Group 4 and 5: Testosterone propionate + low dose (200mg/kg) and high dose (400mg/kg) b...
September 12, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28892815/trans-male-voice-in-the-first-year-of-testosterone-therapy-make-no-assumptions
#4
Adrienne B Hancock, Kayla D Childs, Michael S Irwig
Purpose: The purpose of this study was to prospectively examine changes in gender-related voice domain of pitch measured by fundamental frequency, function-related domains of vocal quality, range, and habitual pitch level and the self-perceptions of transmasculine people during their first year of testosterone treatment. Method: Seven trans men received 2 voice assessments at baseline and 1 assessment at 3, 6, 9, and 12 months after starting treatment. Results: Vocal quality measures varied between and within participants but were generally within normal limits throughout the year...
September 18, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28886024/clomiphene-citrate-effect-in-obese-men-with-low-serum-testosterone-treated-with-metformin-due-to-dysmetabolic-disorders-a-randomized-double-blind-placebo-controlled-study
#5
Carla Pelusi, Vito Angelo Giagulli, Margherita Baccini, Flaminia Fanelli, Marco Mezzullo, Alessia Fazzini, Nicola Bianchi, Matteo Domenico Carbone, Giovanni De Pergola, Marianna Mastroroberto, Antonio Maria Morselli Labate, Renato Pasquali
CONTEXT: Low testosterone (T) levels are often found in obese men with impaired glucose tolerance (IGT) and overt type 2 diabetes (T2DM); however, the mechanisms underlying this condition and its correct therapy are still under debate. OBJECTIVE: To evaluate the effectiveness of clomiphene citrate (CC) in increasing endogenous T levels in obese men with low serum T and with IGT or T2DM treated with metformin (MET). DESIGN: Cross-over, randomized, double-blind, placebo-controlled study...
2017: PloS One
https://www.readbyqxmd.com/read/28865467/beneficial-effects-of-curcumin-nano-emulsion-on-spermatogenesis-and-reproductive-performance-in-male-rats-under-protein-deficient-diet-model-enhancement-of-sperm-motility-conservancy-of-testicular-tissue-integrity-cell-energy-and-seminal-plasma-amino-acids
#6
Omar A H Ahmed-Farid, Maha Nasr, Rania F Ahmed, Rofanda M Bakeer
BACKGROUND: Malnutrition resulting from protein and calorie deficiency continues to be a major concern worldwide especially in developing countries. Specific deficiencies in the protein intake can adversely influence reproductive performance. The present study aimed to evaluate the effects of curcumin and curcumin nano-emulsion on protein deficient diet (PDD)-induced testicular atrophy, troubled spermatogenesis and decreased reproductive performance in male rats. METHODS: Juvenile rats were fed the protein deficient diet (PDD) for 75 days...
September 2, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28854720/combined-androgen-excess-and-western-style-diet-accelerates-adipose-tissue-dysfunction-in-young-adult-female-nonhuman-primates
#7
Oleg Varlamov, Cecily V Bishop, Mithila Handu, Diana Takahashi, Sathya Srinivasan, Ashley White, Charles T Roberts
STUDY QUESTION: What are the separate and combined effects of mild hyperandrogenemia and consumption of a high-fat Western-style diet (WSD) on white adipose tissue (WAT) morphology and function in young adult female nonhuman primates? SUMMARY ANSWER: Combined exposure to mild hyperandrogenemia and WSD induces visceral omental (OM-WAT) but not subcutaneous (SC-WAT) adipocyte hypertrophy that is associated with increased uptake and reduced mobilization of free fatty acids...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28833745/pharmacoepidemiology-of-testosterone-curbing-off-label-prescribing
#8
David J Handelsman
OBJECTIVES: To estimate the impact of the first year of new Pharmaceutical Benefits Scheme (PBS) prescribing criteria that dictate eligibility for national health scheme subsidy of testosterone prescribing. DESIGN: Analysis of cumulative PBS data. SETTING: Retrospective analysis of testosterone prescribing from PBS data. PARTICIPANTS: Nil MAIN OUTCOME MEASURES: PBS expenditure analysed by total expenditure, by state, and by product type as well as the age, indication, and prescriber type for new testosterone treatment...
August 23, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28807822/does-long-term-androgen-deficiency-lead-to-metabolic-syndrome-in-middle-aged-rats
#9
Veronika Borbélyová, Emese Domonkos, Janka Bábíčková, Ľubomíra Tóthová, Mária Kačmárová, Oľga Uličná, Daniela Ostatníková, Július Hodosy, Peter Celec
Evidence from clinical observational studies and animal experiments suggests that hypogonadism is associated with the metabolic syndrome. In most of the experiments, androgen deficiency is induced by gonadectomy in the adulthood and relatively short-term effects of hypogonadism on metabolic parameters are usually observed. The purpose of this study was to evaluate the metabolic effects of long-term androgen deficiency starting before puberty in middle-aged male rats. The components of the metabolic syndrome were examined in male, female and gonadectomized male rats at the age of 18months...
August 12, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28804590/feminizing-adrenocortical-carcinoma-without-gynecomastia
#10
Farida Chentli, Fadila Chabour, Djafer Bouchibane, Nouria Nouar
Malignant feminizing adrenocortical tumors are exceedingly rare. Their main presentation is gynecomastia. In these estrogen secreting tumors (with or without other adrenocortical hormones) lack of gynecomastia is exceptional as in our case. A 44-year-old man presented with abdominal pain. Radiological assessment revealed a tumor measuring 120 × 95 mm in the retroperitoneal area with numerous metastases. Pathological examination pleaded for an adrenal origin with a Weiss's score of 5. Six months later, the tumor relapsed, and he had a second surgery and was sent for hormone assessment...
July 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28795961/testosterone-and-sexual-function
#11
Adriane Fugh-Berman, Anthony R Scialli
PURPOSE OF REVIEW: Testosterone therapy has been advocated in the treatment of symptoms that may represent normal aging. We briefly review randomized clinical trials on the effects of testosterone therapy on sexual function. RECENT FINDINGS: About half of clinical trials showed no benefit of testosterone therapy on any aspect of sexual function. In those studies showing a benefit on some aspect of sexual function, most sexual function domains were not improved. Testosterone therapy has been disappointing in the treatment of erectile dysfunction...
August 8, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28791252/prostate-specific-antigen-5-years-following-stereotactic-body-radiation-therapy-for-low-and-intermediate-risk-prostate-cancer-an-ablative-procedure
#12
Shaan Kataria, Harsha Koneru, Shan Guleria, Malika Danner, Marilyn Ayoob, Thomas Yung, Siyuan Lei, Brian T Collins, Simeng Suy, John H Lynch, Thomas Kole, Sean P Collins
BACKGROUND: Our previous work on early PSA kinetics following prostate stereotactic body radiation therapy (SBRT) demonstrated that an initial rapid and then slow PSA decline may result in very low PSA nadirs. This retrospective study sought to evaluate the PSA nadir 5 years following SBRT for low- and intermediate-risk prostate cancer (PCa). METHODS: 65 low- and 80 intermediate-risk PCa patients were treated definitively with SBRT to 35-37.5 Gy in 5 fractions at Georgetown University Hospital between January 2008 and October 2011...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28772110/leydig-cell-dysfunction-systemic-inflammation-and-metabolic-syndrome-in-long-term-testicular-cancer-survivors
#13
M Bandak, N Jørgensen, A Juul, J Lauritsen, P S Oturai, J Mortensen, P Hojman, J W Helge, G Daugaard
BACKGROUND: Twenty to thirty percent of testicular cancer (TC) survivors have elevated serum levels of luteinising hormone (LH) with or without corresponding low testosterone levels (Leydig cell dysfunction) during clinical follow-up for TC. However, it remains to be clarified if this subgroup of TC survivors has an increased long-term risk of systemic inflammation and metabolic syndrome (MetS) when compared with TC survivors with normal Leydig cell function during follow-up. PATIENTS AND METHODS: TC survivors with Leydig cell dysfunction and a control group of TC survivors with normal Leydig cell function during follow-up were eligible for participation in the study...
July 31, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28770381/effects-of-ascorbic-acid-on-spermatogenesis-and-sperm-parameters-in-diabetic-rats
#14
M Verónica Aguirre-Arias, Victoria Velarde, Ricardo D Moreno
Diabetes mellitus in human and animal models has been correlated with low sperm count, testicular abnormalities, high levels of germ cell death, and oxidative stress. In this study, we focus on three questions: (1) Is germ cell apoptosis stage-specific in diabetic male rats? (2) Could ascorbic acid (AA) reverse oxidative and histological damage and restore testicular dysfunction? (3) Could AA treatment restore fertility parameters in diabetic rats? Adult Sprague-Dawley rats were divided into four groups: control, diabetic, control plus AA, and diabetic plus AA...
August 2, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28766811/do-sperm-parameters-and-infertility-affect-sexuality-of-couples
#15
Fuat Kızılay, Mehmet Şahin, Barış Altay
We aimed to analyse the relationship between sperm parameters and International Index of Erectile Function (IIEF) score, the Female Sexual Function Index (FSFI) score, the testosterone (T) level in infertile men and between FSFI score and partners' fertility. Patients were divided into three groups; (group 1: azoospermia [n = 57], group 2: sperm count <15 million [n = 41], group 3: sperm count >15 million [n = 81]). Patients and their partners filled the IIEF and FSFI forms. The normality of the tests was analysed with Kolmogorov-Smirnov and Shapiro-Wilk tests...
August 2, 2017: Andrologia
https://www.readbyqxmd.com/read/28765273/cross-sex-testosterone-therapy-in-ovariectomized-mice-addition-of-low-dose-estrogen-preserves-bone-architecture
#16
Laura G Goetz, Ramanaiah Mamillapalli, Maureen J Devlin, Amy E Robbins, Masoumeh Majidi-Zolbin, Hugh S Taylor
Cross-sex hormone therapy (XHT) is widely used by transgender people to alter secondary sex characteristics to match their desired gender presentation. Here we investigate the long-term effects of XHT on bone health, using a murine model. Female mice underwent ovariectomy at either 6 or 10 weeks, and began weekly testosterone or vehicle injections. Dual-energy X-ray Absorptiometry (DXA) was performed to measure bone mineral density (BMD) and microCT was performed to compare femoral cortical and trabecular bone architecture...
August 1, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28721218/spontaneous-reossification-of-the-sella-in-transsphenoidal-reoperation-associated-with-strontium-ranelate
#17
Maria Mercedes Pineyro, Daiana Arrestia, Mariana Elhordoy, Ramiro Lima, Saul Wajskopf, Raul Pisabarro, Maria Pilar Serra
Spontaneous reossification of the sellar floor after transsphenoidal surgery has been rarely reported. Strontium ranelate, a divalent strontium salt, has been shown to increase bone formation, increasing osteoblast activity. We describe an unusual case of a young patient with Cushing's disease who was treated with strontium ranelate for low bone mass who experienced spontaneous sellar reossification after transsphenoidal surgery. A 21-year-old male presented with Cushing's features. His past medical history included delayed puberty diagnosed at 16 years, treated with testosterone for 3 years without further work-up...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28721216/switch-to-restoration-therapy-in-a-testosterone-treated-central-hypogonadism-with-erythrocytosis
#18
B Cangiano, C Cacciatore, L Persani, M Bonomi
We describe a case of severe erythrocytosis caused by testosterone replacement therapy in a 66-year-old man affected with hypogonadotropic hypogonadism (HH) determining osteoporosis, resolved by switching to restoration therapy with clomiphene citrate. The patient complained fatigue, loss of libido and defective erections and a spontaneous vertebral fracture despite bisphosphonate therapy and vitamin D supplementation. The examinations proved isolated HH and he was therefore treated with testosterone gel with regression of specific manifestations but elevated hemoglobin and hematocrit values...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28709177/effects-of-testosterone-therapy-on-bmi-blood-pressure-and-laboratory-profile-of-transgender-men-a-systematic-review
#19
I Velho, T M Fighera, P K Ziegelmann, P M Spritzer
Testosterone is the main hormonal agent used for cross-sex hormone therapy in female-to-male transgender persons. Our aim was to systematically review the literature concerning the effects of testosterone on body mass index (BMI), blood pressure, hematocrit, hemoglobin, lipid profile, and liver enzymes in transgender men. PUBMED and EMBASE were searched for studies published until March 2017. Studies were included if they reported interventions with any dose of testosterone and comparison of variables before and during treatment...
September 2017: Andrology
https://www.readbyqxmd.com/read/28704095/sarcopenia-an-endocrine-disorder
#20
Alexis McKee, John E Morley, Alvin M Matsumoto, Aaron Vinik
Sarcopenia is defined as low muscle function (walking speed or grip strength) in the presence of low muscle mass. A simple screening test - the SARC-F - is available to identify persons with sarcopenia. The major endocrine causes of sarcopenia are diabetes mellitus and male hypogonadism. Other causes are decreased physical activity, loss of motor neuron units, weight loss, inflammatory cytokines, reduced blood flow to muscles, very low 25(OH) vitamin D levels and decreased growth hormone and IGF-1. Treatment for sarcopenia includes resistance and aerobic exercise, leucine enriched essential amino acids, and vitamin D...
July 13, 2017: Endocrine Practice
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