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https://www.readbyqxmd.com/read/29770194/clinical-utility-of-hyperbaric-oxygen-therapy-in-genitourinary-medicine
#1
REVIEW
Jason Gandhi, Omar Seyam, Noel L Smith, Gunjan Joshi, Sohrab Vatsia, Sardar Ali Khan
Hyperbaric oxygen therapy (HBOT) is a medical technique which delivers oxygen at ambient pressures to increase the amount of dissolved oxygen in the blood and oxygen distribution to tissues. There are several beneficial properties of HBOT concomitant with elevated oxygen distribution in tissue including anti-inflammation, angiogenesis through vascular endothelial growth factor proliferation, augmented fibroblast activity through fibroblast growth factor proliferation, tissue and wound repair, enhancement of lymphocyte and macrophage activity, increased male testosterone secretion, and bactericidal activity...
January 2018: Medical Gas Research
https://www.readbyqxmd.com/read/29756416/testosterone-and-sarcopenia
#2
REVIEW
Myung Jun Shin, Yun Kyung Jeon, In Joo Kim
Aging affects metabolism, leading to physiological and functional impairments, and is also related to changes in body composition, including reduced skeletal muscle mass and increased body fat. These changes are correlated with the pathophysiology of sarcopenia, which is defined as age-related loss of skeletal muscle mass and strength. Low testosterone levels are associated with unfavorable body composition changes, and sex hormones decrease with aging. Androgen deficiency, along with lack of exercise and poor nutrition, may be among the modifiable contributors to sarcopenia...
May 11, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29740874/short-term-combined-treatment-with-exenatide-and-metformin-is-superior-to-glimepiride-combined-metformin-in-improvement-of-serum-testosterone-levels-in-type-2-diabetic-patients-with-obesity
#3
N Shao, X-Y Yu, Y-M Yu, B-W Li, J Pan, W-H Wu, H-J Zhang, X-F Ma, M Hao, H-Y Kuang
Men with type 2 diabetes (T2D) and obesity are often characterised by low testosterone (T). We aimed to determine whether exenatide (EXE) combined metformin (MET) treatment has a better effect on serum total testosterone (TT) levels than glimepiride (GLI) combined MET treatment in men with T2D and obesity. In a multicentre, 12-week observational study, 176 obese T2D men with failed glycaemic control were included in the study: ninety men (mean age, 43.00 ± 8.50 years) in EXE + MET group and 86 men (mean age, 44...
May 8, 2018: Andrologia
https://www.readbyqxmd.com/read/29739821/c-type-natriuretic-peptide-a-link-between-hyperandrogenism-and-anovulation-in-a-mouse-model-of-polycystic-ovary-syndrome
#4
Adelina M Reis, Kinulpe Honorato-Sampaio
The polycystic ovary (PCO) syndrome (PCOS) is the most common cause of anovulatory infertility in women and is associated with several clinical disorders. Despite the great amount of research in the area, mechanisms involved in the genesis of this syndrome remain poorly understood. In a recent issue of Clinical Science (vol. 132, issue 7, 759-776), Wang and colleagues, highlight the important role of overactivated C-type natriuretic peptide (CNP) and natriuretic peptide receptor 2 (CNP/NPR2) system in preventing oocyte maturation and ovulation in PCOS mice model induced by androgen...
May 16, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29727002/hormone-replacement-therapy-and-opioid-tapering-for-opioid-induced-hypogonadism-among-patients-with-chronic-noncancer-pain-a-systematic-review
#5
Mahmood AminiLari, Priya Manjoo, Samantha Craigie, Rachel Couban, Li Wang, Jason W Busse
Objective: To systematically review evidence addressing the efficacy of testosterone replacement therapy (TRT) and opioid tapering for opioid-induced hypogonadism among patients with chronic noncancer pain. Study Design: Systematic review of randomized controlled trials (RCTs) and observational studies. Methods: We searched MEDLINE, CINAHL, AMED, CENTRAL, CINAHL, DARE, EMBASE, and PsycINFO through August 2017. Eligible studies enrolled ≥10 patients with chronic noncancer pain and opioid-induced hypogonadism and reported the effect of TRT or opioid tapering on a patient-important outcome collected ≥14 days after treatment...
May 2, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29721915/clinical-biochemical-and-molecular-overview-of-transaldolase-deficiency-and-evaluation-of-the-endocrine-function-update-of-34-patients
#6
M Williams, V Valayannopoulos, R Altassan, W K Chung, A C Heijboer, W T Keng, R Lapatto, P McClean, M F Mulder, A Tylki-Szymańska, M J E Walenkamp, M Alfadhel, H Alakeel, G S Salomons, W Eyaid, M M C Wamelink
BACKGROUND: Transaldolase deficiency (TALDO-D) is a rare autosomal recessive inborn error of the pentose phosphate pathway. Since its first description in 2001, several case reports have been published, but there has been no comprehensive overview of phenotype, genotype, and phenotype-genotype correlation. METHODS: We performed a retrospective questionnaire and literature study of clinical, biochemical, and molecular data of 34 patients from 25 families with proven TALDO-D...
May 2, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29715189/co-exposure-to-endocrine-disruptors-effect-of-bisphenol-a-and-soy-extract-on-glucose-homeostasis-and-related-metabolic-disorders-in-male-mice
#7
Masoud Veissi, Sima Jafarirad, Akram Ahangarpour, Seyede Marjan Mohaghegh, Amal Saki Malehi
OBJECTIVES: Bisphenol A (BPA) is a xenoestrogen, which is commonly used as a monomer of polycarbonate plastics food containers and epoxy resins. Little is known about the interaction effects between xeno- and phyto- estrogens on glucose homeostasis or other metabolic disorders. The aim of this study was to examine effects of individual or combined exposure to low doses of BPA and soy extract on glucose metabolism in mice with the goal to establish its potential mechanisms. METHODS: Fifty-four male mice were randomly divided into six groups...
April 1, 2018: Endocrine Regulations
https://www.readbyqxmd.com/read/29713545/systematic-review-of-hormone-replacement-therapy-in-the-infertile-man
#8
REVIEW
Amr El Meliegy, Ahmad Motawi, Mohamed Ahmed Abd El Salam
Objectives: To highlight alternative treatment options other than exogenous testosterone administration for hypogonadal men with concomitant infertility or who wish to preserve their fertility potential, as testosterone replacement therapy (TRT) inhibits spermatogenesis, representing a problem for hypogonadal men of reproductive age. Materials and methods: We performed a comprehensive literature review for the years 1978-2017 via PubMed. Also abstracts from major urological/surgical conferences were reviewed...
March 2018: Arab Journal of Urology
https://www.readbyqxmd.com/read/29709501/spurious-testosterone-laboratory-results-in-a-patient-taking-synthetic-alkaline-phosphatase-asfotase-alfa
#9
Alina G Sofronescu, Meredith Ross, Eric Rush, Whitney Goldner
OBJECTIVES: We report a case of discordant total and free testosterone values in a patient with hypogonadism and juvenile hypophosphatasia after he initiated treatment with asfotase alfa, recombinant tissue non-specific alkaline phosphatase. METHODS: Total testosterone was evaluated using immunoassay pre and post initiation of therapy with asfotase alfa, and free testosterone was evaluated using radioimmunoassay and LC-MS/MS while on asfotase alfa therapy. RESULTS: Total testosterone measured by immunoassay was normal prior to therapy with asfotase alfa, and was low post initiation of therapy...
April 27, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29709433/low-serum-testosterone-is-present-in-nearly-half-of-men-undergoing-artificial-urinary-sphincter-placement
#10
Maxim J McKibben, Jorge Fuentes, Nabeel Shakir, Joceline L Fuchs, Boyd R Viers, Travis Pagliara, Mattias Hofer, Jeremy Scott, Allen F Morey
OBJECTIVES: To report the prevalence of low serum testosterone (LST) in men undergoing AUS placement at a single high-volume institution METHODS: We retrospectively reviewed all men undergoing AUS procedures by a single surgeon from January 2015 to January 2018 to identify men with pretreatment total serum testosterone levels. LST was defined as less than 280 ng/dL. Patients with only post-treatment testosterone levels were excluded. Demographic characteristics and clinical outcomes were compared between men with and without LST...
April 27, 2018: Urology
https://www.readbyqxmd.com/read/29707681/hershberger-assays-for-di-2-ethylhexyl-phthalate-and-its-substitute-candidates
#11
Hee-Su Kim, Yong-Pil Cheon, Sung-Ho Lee
In the present study, we employed Hershberger assay to determine possible androgenic or antiandrogenic activities of three di-2-ethylhexyl phthalate (DEHP) substitute candidates. The assay was carried out using immature castrated Sprague-Dawley male rats. After 7 days of the surgery, testosterone propionate (TP, 0.4 mg/kg/day) and test materials (low dose, 40 mg/kg/day; high dose, 400 mg/kg/day) were administered for 10 consecutive days by subcutaneous (s.c.) injection and oral gavage, respectively. Test materials were DEHP, 2-ethylhexyl oleate (IOO), 2-ethylhexyl stearate (IOS) and triethyl 2-acetylcitrate (ATEC)...
March 2018: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/29704917/testosterone-and-sexual-function-in-men
#12
REVIEW
Giulia Rastrelli, Giovanni Corona, Mario Maggi
Testosterone (T) is deeply involved in every step of the male sexual response. However, the occurrence of sexual disorders cannot be automatically related to a decline in T levels. In fact, this relationship is complicated by organic, relational and psychological factors, which can independently impair sexual function. For example, it is recognized that erectile dysfunction (ED) can result from vascular damage as well as from low levels of T. T therapy (TTh) can improve sexual function but meta-analyses show that it improves erectile function only in men with ED and overt hypogonadism...
June 2018: Maturitas
https://www.readbyqxmd.com/read/29703008/effectiveness-of-testosterone-therapy-in-obese-men-with-low-testosterone-levels-for-losing-weight-controlling-obesity-complications-and-preventing-cardiovascular-events-protocol-of-a-systematic-review-of-randomized-controlled-trials
#13
Amanda S Mangolim, Leonardo A R Brito, Vania S Nunes-Nogueira
BACKGROUND: The use of testosterone replacement therapy in obese men with low testosterone levels has been controversial. This review aims to analyze the effectiveness of testosterone therapy for weight loss and preventing cardiovascular complications in obese men with low testosterone levels. METHODS: We will perform a systematic review according to Cochrane Methodology of randomized studies, including crossover studies, wherein patients are allocated into one of the two groups: testosterone therapy and control (no treatment or placebo)...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29698029/power-increases-the-socially-toxic-component-of-narcissism-among-individuals-with-high-baseline-testosterone
#14
Nicole L Mead, Roy F Baumeister, Anika Stuppy, Kathleen D Vohs
The corrosive effects of power have been noted for centuries, but the self-related changes responsible for those effects have remained somewhat elusive. Narcissists tend to rise to-and abuse-positions of power, so we considered the possibility that positions of power may corrupt because they inflate narcissism. Two pathways were considered: Powerholders abuse their power because having power over others makes them feel superior (grandiosity pathway) or deserving of special treatment (entitlement pathway). Supporting the entitlement pathway, assigning participants to a position of power (vs...
April 2018: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/29695378/comparing-the-effects-of-combined-oral-contraceptives-containing-progestins-with-low-androgenic-and-antiandrogenic-activities-on-the-hypothalamic-pituitary-gonadal-axis-in-patients-with-polycystic-ovary-syndrome-systematic-review-and-meta-analysis
#15
REVIEW
Mina Amiri, Fahimeh Ramezani Tehrani, Fatemeh Nahidi, Ali Kabir, Fereidoun Azizi
BACKGROUND: Different products of combined oral contraceptives (COCs) can improve clinical and biochemical findings in patients with polycystic ovary syndrome (PCOS) through suppression of the hypothalamic-pituitary-gonadal (HPG) axis. OBJECTIVE: This systematic review and meta-analysis aimed to compare the effects of COCs containing progestins with low androgenic and antiandrogenic activities on the HPG axis in patients with PCOS. METHODS: We searched PubMed, Scopus, Google Scholar, ScienceDirect, and Web of Science databases (1980-2017) to identify randomized controlled trials or nonrandomized studies investigating the effect of COCs containing progestins with low androgenic and antiandrogenic activities, including the products containing desogestrel, cyproterone acetate, and drospirenone, on the HPG axis in patients with PCOS...
April 25, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29683475/pharmacological-interventions-for-the-prevention-of-insufficiency-fractures-and-avascular-necrosis-associated-with-pelvic-radiotherapy-in-adults
#16
REVIEW
Qurrat U van den Blink, Kate Garcez, Caroline C Henson, Susan E Davidson, Claire E Higham
BACKGROUND: Pelvic radiotherapy is a treatment delivered to an estimated 150,000 to 300,000 people annually across high-income countries. Fractures due to normal stresses on weakened bone due to radiotherapy are termed insufficiency fractures. Pelvic radiotherapy-related interruption of the blood supply to the hip is termed avascular necrosis and is another recognised complication. The reported incidences of insufficiency fractures are 2.7% to 89% and risk of developing avascular necrosis is 0...
April 23, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29683196/hypogonadism-and-male-obesity-focus-on-unresolved-questions
#17
Mathis Grossmann
Obesity, increasing in prevalence globally, is the clinical condition most strongly associated with lowered testosterone concentrations in men, and presents as one of the strongest predictors of receiving testosterone treatment. While low circulating total testosterone concentrations in modest obesity primarily reflect reduced concentrations of sex hormone binding globulin, more marked obesity can lead to genuine hypothalamic-pituitary-testicular axis (HPT) suppression. HPT axis suppression is likely mediated via pro-inflammatory cytokine and dysregulated leptin signalling and aggravated by associated comorbidities...
April 23, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29680011/testosterone-suppression-in-the-treatment-of-recurrent-or-metastatic-prostate-cancer-a-canadian-consensus-statement
#18
Laurence Klotz, Bobby Shayegan, Chantal Guillemette, Loretta L Collins, Geoffrey Gotto, Dominique Guérette, Marie-Paule Jammal, Tom Pickles, Patrick O Richard, Fred Saad
Testosterone suppression, achieved through orchiectomy or medically induced androgen-deprivation therapy (ADT), is a standard treatment for men with recurrent and metastatic prostate cancer. Current assay methods demonstrate the capacity for testosterone suppression to <0.7 nmol/l, and clinical data support improved outcomes from ADT when lower levels are achieved. Practical clinical guidelines are warranted to facilitate adoption of 0.7 nmol/l as the new standard castrate testosterone level.A pan-Canadian group of experts, representing diverse clinical specialties, identified key clinical issues, searched and reviewed relevant literature, and developed consensus statements on testosterone suppression for the treatment of prostate cancer...
February 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29669061/zearalenone-delays-rat-leydig-cell-regeneration
#19
Songyi Zhou, Yiyan Wang, Leikai Ma, Xianwu Chen, Yao Lü, Fei Ge, Yong Chen, Xiaofang Chen, Qingquan Lian, Xiao-Dong Jin, Ren-Shan Ge
Zearalenone (ZEA), a fungal mycotoxin, is present in a wide range of human foods. By virtual screening, we have identified that ZEA is a potential endocrine disruptor of Leydig cells. The effect of ZEA on Leydig cell development is still unclear. The objective of the present study was to explore whether ZEA affected Leydig cell developmental process and to clarify the underlying mechanism. Adult male Sprague Dawley rats (60 days old) were randomly divided into three groups and these rats received a single intraperitoneal injection of 75 mg/kg ethane dimethane sulfonate (EDS) to eliminate all Leydig cells...
April 16, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29664655/short-term-assessment-of-hsct-effects-on-the-hypothalamus-pituitary-axis-in-pediatric-thalassemic-patients
#20
Amir Ali Hamidieh, Fariba Mohseni, Maryam Behfar, Zohreh Hamidi, Kamran Alimoghaddam, Mohamad Pajouhi, Bagher Larijani, Mohammad-Reza Mohajeri-Tehrani, Ardeshir Ghavamzadeh
BACKGROUND: Beta thalassemia major (BTM) and its treatment by hematopoietic stem cell transplantation (HSCT) may have deleterious effects on the endocrine systems. We assessed endocrine complications of HSCT in pediatric patients for 3 months. METHODS: In 20 (6 female) pediatric major thalassemic patients (mean age of 10.8 ± 3.9 years old), prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), T4, T3, thyroid-stimulating hormone (TSH), IGF-1, testosterone (in males) or estradiol (in females) were measured as a batch at the Endocrinology and Metabolism Research Center (EMRC) of Tehran University of Medical Sciences (TUMS) laboratories before HSCT and 1 and 3 months afterwards...
February 1, 2018: Archives of Iranian Medicine
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