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https://www.readbyqxmd.com/read/28531996/poly-epsilon-caprolactone-nanoparticles-enhance-ursolic-acid-in-vivo-efficacy-against-trypanosoma-cruzi-infection
#1
Juliana Palma Abriata, Josimar O Eloy, Thalita Bachelli Riul, Patricia Mazureki Campos, Marcelo Dias Baruffi, Juliana Maldonado Marchetti
Despite affecting millions of people worldwide, Chagas disease is still neglected by the academia and industry and the therapeutic option available, benznidazole, presents limited efficacy and side effects. Within this context, ursolic acid may serve as an option for treatment, however has low bioavailability, which can be enhanced through the encapsulation in polymeric nanoparticles. Therefore, herein we developed ursolic acid-loaded nanoparticles with poly-ε-caprolactone by the nanoprecipitation method and characterized them for particle size, zeta potential, polydispersity, encapsulation efficiency, morphology by scanning electron microscopy and thermal behavior by differential scanning calorimetry...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531567/impact-of-body-composition-parameters-on-clinical-outcomes-in-patients-with-metastatic-castrate-resistant-prostate-cancer-treated-with-docetaxel
#2
Samantha J Cushen, Derek G Power, Kevin P Murphy, Ray McDermott, Brendan T Griffin, Marvin Lim, Louise Daly, Peter MacEneaney, Kathleen O' Sullivan, Carla M Prado, Aoife M Ryan
BACKGROUND: Body composition may influence clinical outcomes of certain chemotherapeutic agents. We examined the prognostic significance of skeletal muscle mass and adipose tissue on docetaxel toxicity and overall survival in patients with metastatic castrate resistant prostate cancer (mCRPC). METHODS: A retrospective review of patients medical records with mCRPC, treated with docetaxel was conducted. Body composition parameters (skeletal muscle mass, muscle attenuation [MA], visceral and subcutaneous adipose tissue) were measured at L3 by computed tomography (CT) and defined using previously established cut points...
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531393/the-rs10401670-variant-in-resistin-gene-improved-insulin-resistance-response-and-metabolic-parameters-secondaries-to-weight-loss-after-a-hypocaloric-diet
#3
Daniel Antonio de Luis, Rocío Aller, Olatz Izaola, David Primo, R Bachiller
BACKGROUND: The SNP 3'UTR C/T (rs10401670), it is a polymorphism that has been associated with diabetes mellitus and it has been scarcely studied before. As far as we know, no studies on interaction among diet intervention, rs10401670 variant of RETN and metabolic response has been realized. OBJECTIVE: Our aim was to analyze the effects of the rs10401670 RETN gene polymorphism on insulin resistance response and metabolic changes secondary to weight loss after 3 months of a hypocaloric diet in adults obese patients without diabetes mellitus...
August 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531378/cognitive-ability-in-young-adulthood-and-risk-of-dementia-in-a-cohort-of-danish-men-brothers-and-twins
#4
Merete Osler, Gunhild T Christensen, Ellen Garde, Erik L Mortensen, Kaare Christensen
INTRODUCTION: We examined the association between cognitive ability in young adulthood and dementia in Danish men, brothers, and male twins. METHODS: In total, 666,986 men born between 1939 and 1959 were identified for dementia diagnosis in national registries from 1969 to 2016. The association between cognitive ability from draft board examination and dementia was examined using Cox regression. RESULTS: During a 44-year follow-up, 6416 (0...
May 19, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28531326/relationship-among-establishment-durations-kin-relatedness-aggressiveness-and-distance-between-populations-of-eight-invasive-argentine-ant-hymenoptera-formicidae-supercolonies-in-japan
#5
K Sato, H Sakamoto, M Hirata, M Kidokoro-Kobayashi, M Ozaki, S Higashi, T Murakami
We investigated kin relatedness and kin-recognition abilities of the Argentine ant, Linepithema humile (Mayr), an invader from North America that has pervaded Japan for 20 yr, using genetic analyses and behavioral bioassays. From these data and interactions among factors, we formulated an eradication and management time-scale pattern diagram. Relatedness within a colony using microsatellite markers was effectively zero, whereas relatedness estimated by multilocus DNA fingerprinting markers was relatively high...
May 22, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28531276/impact-of-vitamin-a-and-carotenoids-on-the-risk-of-tuberculosis-progression
#6
Omowunmi Aibana, Molly F Franke, Chuan-Chin Huang, Jerome T Galea, Roger Calderon, Zibiao Zhang, Mercedes C Becerra, Emily R Smith, Alayne G Ronnenberg, Carmen Contreras, Rosa Yataco, Leonid Lecca, Megan B Murray
Background: Low and deficient levels of vitamin A are common in low and middle income countries where tuberculosis (TB) burden is high. We assessed the impact of baseline levels of vitamins A and carotenoids on TB disease risk. Methods: We conducted a case-control study nested within a longitudinal cohort of household contacts of pulmonary TB cases in Lima, Peru. We defined cases as HIV-negative household contacts with blood samples who developed TB disease at least 15 days after enrollment of index patient...
May 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28531213/perfusion-mr-imaging-detection-of-carcinoma-arising-from-preexisting-salivary-gland-pleomorphic-adenoma-by-computer-assisted-analysis-of-time-signal-intensity-maps
#7
Ikuo Katayama, Sato Eida, Shuichi Fujita, Yuka Hotokezaka, Misa Sumi, Takashi Nakamura
Tumor perfusion can be evaluated by analyzing the time-signal intensity curve (TIC) after dynamic contrast-enhanced (DCE) MR imaging. Accordingly, TIC profiles are characteristic of some benign and malignant salivary gland tumors. A carcinoma ex pleomorphic adenoma (CXPA) arises from a long-standing pleomorphic adenoma (PA) and has a distinctive prognostic risk depending on the tumor growth potential such as invasion beyond the preexisting capsule. Differentiating CXPA from PA can be very challenging. In this study, we have attempted to discriminate CXPA from PA based on a two-dimensional TIC mapping algorithm...
2017: PloS One
https://www.readbyqxmd.com/read/28530508/influence-of-transmitted-virus-on-the-host-s-immune-response-a-case-study
#8
Shahzma Merani, Michaela Lucas, Pooja Deshpande, Katja Pfafferott, Abha Chopra, Don Cooper, Shay Leary, Fabio Luciani, Silvana Gaudieri
Host hepatitis C virus (HCV)-specific T cell responses and the ability of the virus to escape this response are important correlates of infection outcome. Understanding this host-viral interplay has been difficult given the often asymptomatic nature of acute HCV infection. We studied a recent transmission case to determine whether adapted viral strains can be transmitted and influence the recipient's anti-HCV T cell response. The diversity of viral populations was examined using next-generation sequencing, and HCV-specific T cell interferon (IFN)-γ responses were assessed using a peptide panel representing the autologous viruses...
May 22, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28530486/y-balance-test-performance-following-a-competitive-field-hockey-season-a-pretest-posttest-study
#9
Matthew C Hoch, Lauren A Welsch, Emily M Hartley, Cameron J Powden, Johanna M Hoch
CONTEXT: The Y-Balance Test (YBT) is a dynamic balance assessment used as a preseason musculoskeletal screen to determine injury risk. While the YBT has demonstrated excellent test-retest reliability, it is unknown if YBT performance changes following participation in a competitive athletic season. OBJECTIVE: Determine if a competitive athletic season affects YBT performance in field hockey players. DESIGN: Pretest-posttest. SETTING: Laboratory...
May 22, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28530469/rapid-bacterial-detection-during-endodontic-treatment
#10
D B Herzog, N A Hosny, S A Niazi, G Koller, R J Cook, F Foschi, T F Watson, F Mannocci, F Festy
Bacteria present in the root canal (RC) space following an RC treatment (RCT) can lead to persistent infections, resulting in treatment failure and the need for reintervention or extraction. Currently, there are no standardized methods in use to clinically detect bacterial presence within RC spaces. The use of paper point sampling and fluorescence staining was shown to be a rapid method, able to detect residual bacteria following treatment. The study demonstrated that Calcein acetoxymethyl (AM) proved to be a suitable dye for detecting vital bacteria within mature endodontic biofilms, with an improved sensitivity over colony-forming unit counting in a stressed biofilm model...
June 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28530402/spin-crossover-in-double-salts-containing-six-and-four-coordinate-cobalt-ii-ions
#11
Joanna Palion-Gazda, Barbara Machura, Rafal Kruszynski, Thais Grancha, Nicolás Moliner, Francesc Lloret, Miguel Julve
The preparation and spectroscopic and structural characterization of three cobalt(II) complexes of formulas [Co(tppz)2](dca)2 (1), [Co(tppz)2][Co(NCS)4]·MeOH (2), and [Co(tppz)2][Co(NCO)4]·2H2O (3) [tppz = 2,3,5,6-tetrakis(2-pyridyl)pyrazine and dca = dicyanamide] are reported here. Compounds 1-3 have in common the presence of the cationic [Co(tppz)2](2+) entity where each mer-tridentate tppz ligand coordinates to the cobalt(II) ion equatorially through two pyridyl donors and axially via the pyrazine, completing the six-coordination...
May 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28530094/troponin-c-mutations-partially-stabilize-the-active-state-of-regulated-actin-and-fully-stabilize-the-active-state-when-paired-with-%C3%AE-14-tnt
#12
Tamatha Baxley, Dylan Johnson, Jose Renato Pinto, Joseph Michael Chalovich
Striated muscle contraction is regulated by the actin associated proteins tropomyosin and troponin. Activation of myosin ATPase activity is lowest in the absence of both Ca2+ and activating crossbridges (i.e. S1-ADP or rigor S1). Binding of activating species of myosin to actin at saturating Ca2+ stabilizes the most active state (M state) of actin-tropomyosin-troponin (regulated actin). Ca2+ binding alone produces partial stabilization of the active state. The extent of stabilization at saturating Ca2+ depends on the isoform of the troponin subunits, the phosphorylation state of troponin and, in the case of cardiac muscle, the presence of hypertrophic cardiomyopathy producing mutants of troponin T and troponin I...
May 22, 2017: Biochemistry
https://www.readbyqxmd.com/read/28529810/molecular-profiling-a-case-of-zbtb16-rara-acute-promyelocytic-leukemia
#13
Stephen E Langabeer, Lisa Preston, Johanna Kelly, Matt Goodyer, Ezzat Elhassadi, Amjad Hayat
Several variant RARA translocations have been reported in acute promyelocytic leukemia (APL) of which the t(11;17)(q23;q21), which results in a ZBTB16-RARA fusion, is the most widely identified and is largely resistant to therapy with all-trans retinoic acid (ATRA). The clinical course together with the cytogenetic and molecular characterization of a case of ATRA-unresponsive ZBTB16-RARA APL is described. Additional mutations potentially cooperating with the translocation fusion product in leukemogenesis have been hitherto unreported in ZBTB16-RARA APL and were sought by application of a next-generation sequencing approach to detect those recurrently found in myeloid malignancies...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28529671/the-advection-of-microparticles-mcf-7-and-mda-mb-231-breast-cancer-cells-in-response-to-very-low-reynolds-numbers
#14
Sinéad T Morley, Michael T Walsh, David T Newport
The lymphatic system is an extensive vascular network that serves as the primary route for the metastatic spread of breast cancer cells (BCCs). The dynamics by which BCCs travel in the lymphatics to distant sites, and eventually establish metastatic tumors, remain poorly understood. Particle tracking techniques were employed to analyze the behavior of MCF-7 and MDA-MB-231 BCCs which were exposed to lymphatic flow conditions in a 100 μm square microchannel. The behavior of the BCCs was compared to rigid particles of various diameters (η = dp/H= 0...
May 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28529663/the-modified-dunn-procedure-for-slipped-capital-femoral-epiphysis-the-bernese-experience
#15
M Tannast, L M Jost, T D Lerch, F Schmaranzer, K Ziebarth, K A Siebenrock
PURPOSE: Based on previous investigations on the vascular blood supply to the femoral head, a technique for anatomical reduction after slipped capital femoral epiphysis was developed. This technique is a modification of the original technique by Dunn using a retinacular soft-tissue flap. This allows the visual control of the epiphyseal vascular blood supply. We report the experience at the inventor's institution with a critical discussion of the available literature. METHODS: Using a trochanteric osteotomy for surgical dislocation of the hip, a retinacular soft tissue flap is created containing the deep branch of the medial femoral circumflex artery, the external rotators and the capsule...
April 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28529650/diagnostic-accuracy-of-ga-68-hbed-cc-psma-ligand-pet-ct-before-salvage-lymph-node-dissection-for-recurrent-prostate-cancer
#16
Cordula A Jilg, Vanessa Drendel, H Christian Rischke, Teresa Beck, Werner Vach, Kathrin Schaal, Ulrich Wetterauer, Wolfgang Schultze-Seemann, Philipp T Meyer
Background: By targeting the prostate-specific membrane antigen (PSMA) on prostate cancer (PCa) cells PSMA-PET/CT shows great potential in locating the site of biochemical recurrence even at low PSA (Prostate-specific antigen)-levels. Accurate imaging of PCa recurrent lymph node metastases (LNM) is crucial for metastases directed therapies such as salvage-lymph node dissection (salvage-LND). Objective: To evaluate the diagnostic accuracy of PSMA-PET/CT for detection of affected lymph-node regions at salvage-LND for nodal recurrence of PCa...
2017: Theranostics
https://www.readbyqxmd.com/read/28529616/lymphocyte-monocyte-ratio-is-a-novel-predictor-for-early-stage-extranodal-natural-killer-t-cell-lymphoma-nasal-type
#17
Qiao-Xuan Wang, Shao-Hua Li, Bao-Yan Ji, Han-Yu Wang, Yi-Yang Li, Ling-Ling Feng, Kai Chen, Yun-Fei Xia, Yu-Jing Zhang
Objective: Great heterogeneity exists in clinical behavior and survival outcome in patients with stage IE/IIE extranodal natural killer/T-cell lymphoma, nasal type (ENKTL). In this study, we proposed lymphocyte/monocyte ratio (LMR) as a new prognostic factor for these early stage ENKTL. Methods: We retrospectively examined the LMR as a prognostic variable in a cohort of 379 patients with newly diagnosed stage IE/IIE ENKTL. The relationship between the LMR and clinicopathologic variables were analyzed in Kaplan-Meier log-rank survival analysis, and the Cox proportional hazards model was used to determine the survival significance of the LMR for both progression-free survival (PFS) and overall survival (OS)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28529487/cardiac-baroreflex-variability-and-resetting-during-sustained-mild-effort
#18
Mair Zamir, Mark B Badrov, T Dylan Olver, J Kevin Shoemaker
This exploratory study assessed the pattern of closed-loop baroreflex resetting using multi-logistic-curve analysis. Operating point gain and ranges of RR-interval (RRI) and systolic blood pressure (SBP) are derived to examine how these relate to sympathetic activation. Sustained low-intensity isometric handgrip exercise, with a period of post-exercise circulatory occlusion (PECO), provided a model to study baroreflex resetting because the progression toward fatigue at constant tension induces a continuous increase in volitional contribution to neuro-cardiovascular control...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28529007/risk-factors-for-depression-differential-across-age
#19
Roxanne Schaakxs, Hannie C Comijs, Roos C van der Mast, Robert A Schoevers, Aartjan T F Beekman, Brenda W J H Penninx
INTRODUCTION: The occurrence of well-established risk factors for depression differs across the lifespan. Risk factors may be more strongly associated with depression at ages when occurrence, and therefore expectance, is relatively low ("on-time off-time" hypothesis). This large-scale study examined absolute and relative risks of established risk factors for depression across the lifespan. METHODS: Participants were 2,215 currently or never depressed adults aged 18 to 93 years from two cohort studies: NESDA and NESDO...
April 7, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28528897/lateral-lumbar-interbody-fusion-at-the-lumbosacral-junction
#20
Timothy L T Siu, Kainu Lin
Due to the obstruction of the iliac crest and the retroperitoneal vessels, lateral lumbar interbody fusion (LLIF) is generally considered contraindicated at the lumbosacral junction (LSJ). In particular the 'rise' of the psoas from the vertebral column in the lower lumbar segments has been associated with significant overlap of the lumbar plexus with the vertebral body and exclusion of a safe transpsoas entry. However in selected individuals anatomical variations may help circumvent the difficulties and the anatomical corridor posterior to the lumbar plexus may provide an alternative to the conventional anterior approach...
May 18, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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