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https://www.readbyqxmd.com/read/27900921/-a-fixed-drug-eruption-caused-by-paracetamol
#1
L van Zogchel, T Hendriks, S Adriaens, I Diederen, E Herremans
BACKGROUND: Fixed drug eruption is a hypersensitive skin response to drugs, which can present itself in different ways. The skin lesions are usually solitary, but can also appear as a maculopapular rash, Stevens-Johnson syndrome or toxic epidermal necrolysis. While fixed drug eruptions can be caused by various drugs, paracetamol is responsible in 1.5% of cases. CASE DESCRIPTION: A 58-year-old man was seen in general practice with a five-year-old exanthema on his torso, arms and legs...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27893468/linear-folliculotropic-cd30-positive-lymphomatoid-drug-reaction
#2
Yi-Chin Chen, Yu-Hung Wu
We report a unique case of probable drug-induced CD30-positive lymphomatoid reaction. A 58-year-old woman presented with bilateral facial eruptions of 3 weeks duration composed of erythematosus papules in a linear distribution. The pathological features demonstrated a dense dermal and follicular infiltrate of many medium- to large-sized atypical CD30-positive lymphoid cells. The rash resolved rapidly after discontinuation of her medication 1 week later and did not recur. This case highlights the importance of clinicopathological correlation...
November 22, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27886905/cutaneous-manifestation-of-drug-allergy-and-hypersensitivity
#3
REVIEW
Anna Zalewska-Janowska, Radoslaw Spiewak, Marek L Kowalski
Drug hypersensitivity reactions may manifest with either organ-specific or systemic symptoms, but cutaneous eruptions are the most common manifestations. Different medications may cause identical skin symptoms, whereas hypersensitivity to a single drug may manifest with various patterns of symptoms depending on the pathomechanism of hypersensitivity. Drug reactions should be also taken into account in the differential diagnosis of numerous skin rashes. Analysis of morphology of drug-induced lesions, about potential immunologic or nonimmunological mechanisms, is important for the final diagnosis...
February 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/27867741/pityriasis-rubra-pilaris-like-eruption-following-insulin-therapy-initiation
#4
Talel Badri, Anissa Zaouak, Ghozlane Lakhoua, Wafaa Koubaa, Sami Fennich, Ahmed Zaiem
Pityriasis rubra pilaris (PRP) is a chronic disorder of keratinization of unclear pathogenesis. PRP-like eruptions induced by drugs have rarely been described. A previously healthy 29-year-old man presented with a generalized, rapidly spreading, erythematosquamous dermatosis, that started three days after initiation of subcutaneous insulin therapy for diabetes mellitus type 1. Clinical and histopathological features were consistent with a PRP-like eruption, possibly due to insulin therapy. The patient was switched to insulin analogue therapy and a complete healing of all lesions was achieved after two months...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27862184/serum-sickness-like-drug-reaction-two-cases-with-a-neutrophilic-urticarial-pattern
#5
Cuong V Nguyen, Daniel D Miller
The diagnosis of serum sickness-like reaction (SSLR) is typically based on clinical findings. Histopathologic examination is often deferred, as these eruptions commonly present in young children, and often to primary care providers. A Pubmed literature search revealed only 5 existing cases of SSLR with described cutaneous histopathologic features. We report two cases of serum sickness-like reaction, one each to bupropion and cefazolin. Skin biopsy findings in both cases demonstrated a neutrophil-predominant urticarial pattern resembling neutrophilic urticaria or neutrophilic urticarial dermatosis...
November 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27828643/fixed-drug-eruption-by-etoricoxib-confirmed-by-patch-test
#6
Aline Soares de Sousa, José Carlos Cardoso, Miguel Pinto Gouveia, Ana Rita Gameiro, Vera Barreto Teixeira, Maria Gonçalo
Non-steroidal, anti-inflammatory drugs, followed by antibiotics, are the main causes of fixed drug eruption. They provoke one or several round erythematous or bullous lesions that recur in the same place after taking the causative medication. A positive patch test on residual, lesional skin can replace satisfactorily oral reintroduction. We describe the case of a 74-year-old woman with numerous, rounded, erythematous lesions on the trunk and recurrent blistering on the fifth right-hand finger, which developed a few hours after taking etoricoxib...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27817206/subacute-radiation-dermatitis-following-an-interventional-cardiology-procedure
#7
Nélia Cunha, Pedro Cardoso, Joana Cabete
Although radiation dermatitis is a widely known complication of radiotherapy, its association with fluoroscopy-guided interventional procedures is yet underrecognized. We present a case of a 66-year-old man with a left scapular cutaneous lesion, initially diagnosed as a fixed drug eruption. The subsequent knowledge of a previous percutaneous aortic paravalvular leak closure procedure allowed a correct clinicopathological correlation and the final diagnosis of subacute radiodermatitis associated with fluoroscopy...
November 6, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27796328/clinical-analysis-of-hiv-aids-patients-with-drug-eruption-in-yunnan-china
#8
Yu-Ye Li, Yong-Mei Jin, Li-Ping He, Jin-Song Bai, Jun Liu, Min Yu, Jian-Hua Chen, Jing Wen, Yi-Qun Kuang
Drug eruption is the most common clinical presentation in patients with HIV/AIDS. The systemic clinical and risk factors associated with drug eruption remain unknown. A retrospective analysis in HIV/AIDS patients with drug eruption was carried out with demographic data, epidemiological data, clinical characteristics, laboratory data and follow-up data. The risk factors correlated with prognosis were assessed by case control analysis. A total of 134 out of 1817 HIV/AIDS patients (7.4%) presented drug eruptions...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27790676/autoantibodies-against-members-of-the-plakin-family-in-severe-drug-eruptions-does-the-phenomenon-matter
#9
C-Y Chu
No abstract text is available yet for this article.
November 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27780370/ornidazole-induced-fixed-drug-reaction-on-sole-case-report-and-review-of-the-literature
#10
Selma Emre, Hilal Ahsen, Akın Aktaş
BACKGROUND: Fixed drug eruption is a special variant of drug reaction which is seen on skin or mucous membrane and typically recurs at the same location. Ornidazole-induced fixed drug eruption cases have been reported extremely rare. CASE: The 48-years old female patient was diagnosed as ornidazole-induced fixed drug reaction on the sole. The patient's history revealed that the lesion occurred for the third time in the last 6 months and she was administered ornidazole tablet by the gynecologist for 3 times due to genitourinary tract infection in the last 6 months...
October 26, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27777187/lichenoid-drug-eruption-caused-by-adalimumab-a-case-report-and-literature-review
#11
Akiha Inoue, Yu Sawada, Takashi Yamaguchi, Shun Ohmori, Daisuke Omoto, Sanehito Haruyama, Manabu Yoshioka, Etsuko Okada, Motonobu Nakamura
No abstract text is available yet for this article.
October 24, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27765414/-eruptive-epidermoid-cysts-during-topical-imiquimod-treatment
#12
A-S Dillies, V Gras-Champel, S Fraitag-Spinner, F Al Saïf, E Carmi
BACKGROUND: Imiquimod is a local immune-response modifier that works by stimulating innate and acquired immunity. It is frequently used to treat superficial basal cell carcinoma, the most common form of skin cancer. Marked local inflammatory reaction is common during treatment. We report a case of the rare condition, multiple eruptive milia, during topical imiquimod therapy. PATIENTS AND METHODS: A 67-year-old male patient presented infiltrating basal cell carcinoma above the left eyebrow...
October 17, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27759434/drug-induced-eruptive-melanocytic-nevi
#13
Gino A Vena, Maria Concetta Fargnoli, Nicoletta Cassano, Giuseppe Argenziano
The sudden eruption of melanocytic nevi has been associated with a number of conditions, such as bullous skin diseases, immunodeficiency and immunosuppression. The exact mechanisms leading to the development of eruptive melanocytic nevi are unknown. Areas covered: The aim of this article is to review the literature concerning eruptive melanocytic nevi following the administration of immunosuppressive drugs and other medications. Expert opinion: The literature regarding the development of eruptive nevi in association with pharmacological therapies includes a relatively low number of reports...
October 19, 2016: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/27757979/a-case-of-erythema-multiforme-drug-eruption-associated-with-erythrodermic-psoriasis-induced-by-sofosbuvir-and-daclatasvir
#14
Y Wang, P Liu
WHAT IS KNOWN AND THE OBJECTIVE: Sofosbuvir (SOF) and daclatasvir (DCV) have revolutionized the treatment of hepatitis C virus and now represent the preferred therapy for this disease. Limited data are available on the dermatological side effects resulting from co-administration of SOF and DCV. CASE DESCRIPTION: We report a case of an erythema multiforme drug eruption associated with erythrodermic psoriasis induced by SOF and DCV. After ceasing treatment, the skin condition significantly improved...
October 18, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27749688/hla-a-02-alleles-are-associated-with-tetanus-antitoxin-induced-exanthematous-drug-eruptions-in-chinese-patients
#15
Sijia Yan, Sheng-An Chen, Wen Zhang, Fanping Yang, Ying Yang, Qinyuan Zhu, Huizhong Zhu, Xinfen Sun, Menglin Jiang, Yu Su, Lirong Zhang, Qinghe Xing, Xiaoqun Luo
OBJECTIVE: Tetanus antitoxin (TAT) is an effective antitetanus medicine, but may sometimes cause adverse drug reactions such as rapid-onset anaphylactic shock and late-onset cutaneous adverse drug reactions, including exanthematous drug eruptions (EDE). Human leukocyte antigen (HLA) class I alleles are strongly associated with different types of cutaneous adverse drug reactions. This study aimed to assess whether there is an association between TAT-induced EDE and HLA-A, HLA-B, and HLA-C alleles in the Chinese Han population...
October 5, 2016: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/27748265/illustration-of-diagnostic-and-prognostic-difficulties-during-the-early-stages-of-generalized-bullous-fixed-drug-eruptions
#16
Mathieu Bataille, Marlène Vonarx, Annie Vermersch-Langlin
No abstract text is available yet for this article.
October 17, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27748262/a-possible-role-of-il-23-producing-cells-in-a-patient-with-psoriasiform-drug-eruption-due-to-tazobactam-and-piperacillin-hydrate-a-case-study-and-literature-review
#17
Natsuko Saito-Sasaki, Yu Sawada, Shun Ohmori, Daisuke Omoto, Sanehito Haruyama, Manabu Yoshioka, Daisuke Nishio, Etsuko Okada, Motonobu Nakamura
No abstract text is available yet for this article.
October 17, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27748259/drug-eruption-caused-by-secukinumab
#18
Mayu Shibata, Yu Sawada, Takashi Yamaguchi, Shun Ohmori, Daisuke Omoto, Sanehito Haruyama, Manabu Yoshioka, Etsuko Okada, Motonobu Nakamura
No abstract text is available yet for this article.
October 17, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27738400/evaluation-of-the-patients-diagnosed-with-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-a-single-center-experience
#19
Şükrü Çekiç, Yakup Canıtez, Nihat Sapan
AIM: Stevens Johnson syndrome and toxic epidermal necrolysis are severe acute mucocutaneous diseases. In this study, we evaluated the clinical aspects of Steven Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap patients who admitted to our clinics in the last five years. MATERIAL AND METHODS: Eleven patients diagnosed as Stevens-Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in Department of Pediatric Allergy in Uludağ University School of Medicine were included in this study...
September 2016: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/27732743/clinical-approach-on-challenge-and-desensitization-procedures-with-aspirin-in-patients-with-ischemic-heart-disease-and-nsaid-hypersensitivity
#20
G Cortellini, A Romano, A Santucci, A Barbaud, S Bavbek, D Bignardi, M Blanca, P Bonadonna, M T Costantino, J J Laguna, C Lombardo, L Losappio, J Makowska, A Nakonechna, O Quercia, E A Pastorello, V Patella, I Terreehorst, S Testi, J R Cernadas, J Dionicio Elera, D Lippolis, S Voltolini, D Grosseto
BACKGROUND: Hypersensitivity to acetylsalicylic acid (ASA) constitutes a serious problem for subjects with coronary artery disease. In such subjects, physicians have to choose the more appropriate procedure between challenge and desensitization. As the literature on this issue is sparse, the present study aims to establish in these subjects clinical criteria for eligibility for an ASA challenge and/or desensitization. METHODS: Collection and analysis of data on ASA challenges and desensitizations from 10 allergy centers, as well as consensus among the related physicians and an expert panel...
October 12, 2016: Allergy
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