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Drug rash with eosinophilia and systemic symptoms

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https://www.readbyqxmd.com/read/29756718/-drug-reaction-with-eosinophilia-and-systemic-symptoms-due-to-carbamazepine-pediatric-case
#1
Rocío Del P Pereira-Ospina, Ana M Bejarano-Quintero, José M Suescún-Vargas, Javier Y Pinzón-Salamanca
Severe skin reactions include Stevens-Johnson Syndrome, toxic epidermal necrolysis and Drug reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome, which are uncommon in the pediatric population (incidence 1/1000- 10 000 children), but they have bad prognosis. Drug-sensitive Syndrome with eosinophilia and systemic symptoms consists in rash, hematological abnormalities, lymphadenopathy and organ involvement. We report the case of a 12-year-old male patient who developed this pathology after initiating anticonvulsant therapy with carbamazepine...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29703869/a-10-years-retrospective-study-on-severe-cutaneous-adverse-reactions-scars-in-a-tertiary-hospital-in-penang-malaysia
#2
C H Loo, W C Tan, Y H Khor, L C Chan
INTRODUCTION: Severe cutaneous adverse drug reactions (SCARs) are not uncommon and potentially lifethreatening. Our objective is to study the patient characteristics, the pattern of implicated drugs and treatment outcome among patients with SCARs. METHODS: A 10-year retrospective analysis of SCARs cases in Penang General Hospital was carried out from January 2006 to December 2015. Data collection is based on the Malaysian Adverse Drug Reactions Advisory Committee registry and dermatology clinic records...
April 2018: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29607632/trichloroethylene-hypersensitivity-syndrome-should-be-considered-when-diagnosing-dress-syndrome
#3
Young Joong Kang, Jihye Lee, Jungho Ahn, Soonwoo Park, Mu Young Shin, Hye Won Lee
Trichloroethylene (TCE) is an organic solvent that is used for degreasing and removing impurities from metal parts. However, this solvent's characteristics and hypersensitivity can produce clinical patterns and laboratory data that mimic drug rash with eosinophilia and systemic symptoms (DRESS) syndrome. Thus, exposure confirmation is critical to making an accurate diagnosis. This is a case of TCE-induced hypersensitivity syndrome (TCE HS) in a 24-year-old Indonesian man who was working in an electro-plating business...
April 2, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29588957/dress-syndrome-a-case-of-cross-reactivity-with-lacosamide
#4
Man Kei Fong, Bun Sheng
A 42-year-old patient with epilepsy was admitted to the hospital for fever and generalized skin rash. He has known allergy to phenytoin. Valproate was started in 2012, but failed to control his seizure despite gradual increase in dosage. Phenobarbitone was added 16 days before admission and was stopped on admission. He was treated with beta-lactam antibiotics. The rash subsided gradually after the cessation of phenobarbitone. Lacosamide was subsequently added for seizure control. Unfortunately, he developed drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome soon after introduction of lacosamide that required the use of systemic steroid for acute hepatitis...
June 2017: Epilepsia Open
https://www.readbyqxmd.com/read/29541744/association-between-hla-b-1301-and-dapsone-induced-cutaneous-adverse-drug-reactions-a-systematic-review-and-meta-analysis
#5
Wimonchat Tangamornsuksan, Manupat Lohitnavy
Importance: Dapsone-induced hypersensitivity syndrome (DHS) is a life-threatening adverse drug reaction. Based on available epidemiologic studies, HLA genotypes may play an important role in DHS. Objective: To assess the association between HLA-B*1301 and dapsone-induced cutaneous adverse drug reactions (cADRs). Data Sources: Human studies investigating associations between HLA-B*1301 and dapsone-induced cADRs were systematically searched without language restriction from the inception of each database until September 12, 2017, in PubMed, the Human Genome Epidemiology Network), and the Cochrane Library...
April 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29521632/overexpression-of-cytotoxic-proteins-correlates-with-liver-function-impairment-in-patients-with-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress
#6
Fanping Yang, Sheng-An Chen, Xiaojin Wu, Qingyuan Zhu, Xiaoqun Luo
Drug reaction with eosinophilia and systemic symptoms (DRESS) is characterised by skin rash and multivisceral involvement. The liver is the organ most frequently affected and the degree of liver function impairment often correlates with the mortality rate of DRESS. We aimed to examine the expression of cytotoxic proteins, including soluble Fas ligand (sFasL), TNF-α, granulysin, perforin, and granzyme B in the sera and skin lesions of patients with DRESS and evaluate their clinical significance. Our cohort consisted of 21 patients with DRESS and control groups including 39 patients with Stevens-Johnson syndrome/toxic epidermal necrolysis, 21 patients with maculopapular eruption, and 29 normal controls...
February 1, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29519170/dress-syndrome-a-detailed-insight
#7
Sapan Kumar Behera, Saibal Das, Alphienes Stanley Xavier, Sandhiya Selvarajan
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a serious and potentially fatal adverse effect to therapeutic medications. The incidence of this condition varies among different ethnicities because of the difference in the genetic makeup. Though fever, rash and eosinophilia are essential features for the diagnosis of this syndrome, these vary from patient to patient along with the involvement of various organs such as liver, kidney, lungs, pancreas, etc. Some of the atypical features are dysphagia, agranulocytosis, and chylous ascites...
March 15, 2018: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/29440628/drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-secondary-to-furosemide-case-report-and-review-of-literature
#8
Jared James, Yasser M Sammour, Andrew R Virata, Terri A Nordin, Igor Dumic
BACKGROUND DRESS is a rare, life threatening syndrome that occurs following exposure to certain medications, most commonly antibiotics and antiepileptics. While sulfonamide antibiotics are frequently implicated as causative agents for DRESS syndrome, furosemide, a nonantibiotic sulfonamide, has not been routinely reported as the causative agent despite its widespread use. CASE REPORT A 63 year old male who started furosemide for lower extremity edema 10 weeks prior presented with diarrhea, fever of 39.4°C, dry cough and maculopapular rash involving >50% of his body...
February 14, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29432504/a-retrospective-study-of-dress-drug-reaction-with-eosinophilia-and-systemic-symptoms
#9
Dorota Mehrholz, Anna Emilia Urban, Marta Herstowska, Roman Nowicki, Wiesław Cubała, Wioletta Barańska-Rybak
OBJECTIVES: DRESS (drug reaction with eosinophilia and systemic syndrome) is qualified as hypersensitivity after drug reaction. This syndrome may occur due to any medication intake. There are three main groups of symptoms defining DRESS: skin lesions, hematological abnormalities and internal organ involvement. METHODS: A retrospective study was performed on a group of 261 patients with drug reactions hospitalized in the Clinic of Dermatology from 2004 until 2017...
December 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29417040/diagnostic-criteria-for-drug-rash-and-eosinophilia-with-systemic-symptoms
#10
Ashok Kumar Pannu, Atul Saroch
No abstract text is available yet for this article.
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29386835/drug-reaction-with-eosinophilia-and-systemic-symptoms-associated-with-reactivation-of-epstein-barr-virus-and-or-cytomegalovirus-leading-to-hemophagocytic-syndrome-in-one-of-two-patients
#11
Jianhua Liang, Hui Qu, Xiaowen Wang, Aiping Wang, Lingling Liu, Ping Tu, Ruoyu Li, Mingyue Wang
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a hypersensitivity reaction characterized by maculopapular rash, exfoliative dermatitis, lymphadenopathy, fever, eosinophilia, and involvement of internal organs. Evidence for reactivation of herpes family viruses has been observed in some DRESS patients, and activated CD8+ T lymphocytes are largely directed against Epstein-Barr virus. Here, we report two cases complicated with this infection. Both patients received antibiotics and non-steroidal anti-inflammatory drugs...
February 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29368897/-adverse-cutaneous-reactions-to-drugs
#12
Irvin Suástegui-Rodríguez, Karin Ivette Campos-Jiménez, Judith Domínguez-Cherit, Silvia Méndez-Flores Malvido-Torres
Adverse cutaneous reactions to drugs are any undesirable change in the structure or function of the skin. These are among the adverse side effects to common drugs. The most commonly implicated drugs are antibiotics and anticonvulsants. Cutaneous clinical manifestations are diverse ranging from mild or moderate reactions, such as urticaria and maculopapular rash, to severe cutaneous adverse reactions (SCAR), which are known due to their high morbidity and mortality (among these: Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS)...
January 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29367368/lamotrigine-induced-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-during-primary-epstein-barr-virus-ebv-infection
#13
Ibrahim Tawhari, Fawaz Tawhari, Mossab Aljuaid
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe, potentially life-threatening idiosyncratic drug reaction that may result in skin eruption, mucous membrane involvement, eosinophilia, atypical lymphocytosis and lymphadenopathy, with wide-ranging internal organ involvement. The authors report the case of a 21-year-old man who was prescribed lamotrigine for anxiety disorder. After 2 weeks of treatment, he developed a pruritic morbilliform rash on his trunk and upper extremities that was associated with fever, sore throat, bilateral scleral injection, nausea, vomiting and abdominal pain...
January 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29356180/severe-adverse-cutaneous-drug-reactions-to-antiepileptic-drugs-18-years-of-experience-in-a-tertiary-referral-dermatology-clinic-in-turkey
#14
LETTER
E Özkaya, S Kılıç
No abstract text is available yet for this article.
January 22, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29350020/cutaneous-drug-reactions-to-antiepileptic-drugs-and-relation-with-hla-alleles-in-the-turkish-population
#15
S Büyüköztürk, Ç Kekik, A Z Gökyiğit, F I Tezer Filik, G Karakaya, S Saygi, A B Dursun, S Kirbaş, A Tüfekçi, A Z Sin, I Aydoğdu, M H Sorgun, N Aydin, A Gelincik, B Çolakoğlu, G Çelik, F Oğuz
Background and objective. Many studies have shown associations between HLAB*15:02, HLA-A*31:01 and carbamazepine (CBZ)-induced delayed cutaneous hypersensitivity reactions. The aim of this study is to evaluate a possible association between delayed cutaneous reactions to antiepileptic drugs (AEDs) and certain HLA-A and HLA-B alleles in the Turkish population. Methods. The study consisted of 3 groups: Group I (reactive group) included the patients who had documented delayed cutaneous reactions to any antiepileptic drug...
January 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29334124/use-of-antiviral-medications-in-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-a-case-of-infantile-dress
#16
Maggie L Chow, David Kim, Sonia Kamath, David Peng, Minnelly Luu
A 3-month-old girl with Sturge-Weber syndrome presented with a morbilliform rash, eosinophilia, and fulminant liver failure to our tertiary pediatric hospital. She was diagnosed with drug reaction with eosinophilia and systemic symptoms complicated by viremia and evidence of viral hepatitis on liver biopsy. We discuss the role of viral reactivation in drug reaction with eosinophilia and systemic symptoms and the relevance of antiviral therapy in management.
March 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29296640/successful-use-of-dabrafenib-after-the-occurrence-of-drug-rash-with-eosinophilia-and-systemic-symptoms-dress-induced-by-vemurafenib
#17
Camille Pinard, Claire Mignard, Agnès Samain, Anne-Bénédicte Duval-Modeste, Pascal Joly
No abstract text is available yet for this article.
November 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/29282040/case-report-atypical-presentation-of-vancomycin-induced-dress-syndrome-a-case-report-and-review-of-the-literature
#18
Olivia Wilcox, Mohamed Hassanein, John Armstrong, Nader Kassis
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe hypersensitivity drug reaction involving the skin and multiple internal organ systems. The symptoms typically present with fever and skin rash, and rapidly progress to multiple organ failures. Vancomycin is a rare drug to cause DRESS syndrome with 23 cases reported to date. CASE PRESENTATION: We described a case of a 39 year-old man who was treated with vancomycin for osteomyelitis of the foot...
December 28, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29276875/drug-reaction-with-eosinophilia-and-systemic-symptoms-in-a-child-on-multiple-antiepileptics
#19
Jyotindra Narayan Goswami, Pankaj C Vaidya, Arushi Gahlot Saini, Dipankar De, Bishan Dass Radotra, Pratibha D Singhi
Goswami JN, Vaidya PC, Saini AG, De D, Radotra BD, Singhi PD. Drug reaction with eosinophilia and systemic symptoms in a child on multiple antiepileptics. Turk J Pediatr 2017; 59: 197-199. Drug reaction with eosinophilia and systemic symptoms (DRESS) is an adverse drug-reaction that may mimic systemic illnesses and have a fulminant presentation. We describe an 8-year-old girl with epilepsy and exposure to multiple anti-epileptics who presented with fever, extensive maculopapular rash, cervical lymphadenopathy, hepatomegaly, progressive anemia and transaminitis...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29276264/highly-probable-drug-reaction-with-eosinophilia-and-systemic-symptoms-syndrome-associated-with-lenalidomide
#20
Anusha Shanbhag, E Ryan Pritchard, Kshitij Chatterjee, Drayton A Hammond
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening hypersensitivity reaction to medications. We report a case of a 75-year-old African American female who presented with generalized rash with desquamation and malodorous secretions. She was febrile and hypotensive, and required vasopressors for hemodynamic instability. Sepsis secondary to skin or soft tissue infection was considered initially. However, she recently was started on lenalidomide for treatment of her multiple myeloma, and her white blood cell count of 17 K/µL with 55% eosinophils along with peripheral smear showing eosinophilia suggested lenalidomide-induced rash...
June 2017: Hospital Pharmacy
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