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https://www.readbyqxmd.com/read/27900064/enzalutamide-induced-acute-generalized-exanthematous-pustulosis
#1
Chloé Alberto, Maria Polina Konstantinou, Catherine Martinage, Eline Casassa, Emilie Tournier, Haleh Bagheri, Vincent Sibaud, Loïc Mourey, Juliette Mazereeuw-Hautier, Nicolas Meyer, Carle Paul, Cristina Bulai Livideanu
INTRODUCTION: Enzalutamide (Xtandi®) is a new potent inhibitor of the signaling pathway for the androgen receptor with a half-life of 5.8 days. It has been on the market for the treatment of metastatic castration-resistant prostate cancer since November 2013. OBJECTIVE: We report the first case of acute generalized exanthematous pustulosis (AGEP) induced by enzalutamide. OBSERVATION: A 62-year-old male patient with no significant medical history, was diagnosed in April 2014 with metastatic prostatic adenocarcinoma...
November 13, 2016: Journal of Dermatological Case Reports
https://www.readbyqxmd.com/read/27884600/steaps-comprise-a-novel-inflammatory-nexus-in-pustular-skin-disorders
#2
Yun Liang, Xianying Xing, Maria A Beamer, William R Swindell, Mrinal K Sarkar, Liza Wolterink Roberts, John J Voorhees, J Michelle Kahlenberg, Paul W Harms, Andrew Johnston, Johann E Gudjonsson
BACKGROUND: Pustular skin disorders are a category of difficult-to-treat and potentially life threatening conditions that involve the appearance of neutrophil rich pustules. The molecular basis of most pustular skin conditions has remained unknown. OBJECTIVE: We sought to investigate the molecular basis of three pustular skin disorders, generalized pustular psoriasis (GPP), palmoplantar pustulosis (PPP), and acute generalized exanthematous pustulosis (AGEP). METHODS: Microarray analyses were performed to profile genome-wide gene expression of skin biopsies obtained from GPP, PPP, AGEP patients and normal controls...
November 21, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27779083/severe-drug-hypersensitivity-reactions-clinical-pattern-diagnosis-etiology-and-therapeutic-options
#3
Maren Paulmann, Maja Mockenhaupt
Severe cutaneous adverse reactions (SCAR) are known for a high morbidity and mortality. They may be life-threatening for the affected patient and difficult to accomplish for the patient's family and the treating physician. Such conditions include not only bullous reactions like toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS), but also acute generalized exanthematous pustulosis (AGEP) and drug reaction with eosinophilia and systemic symptoms (DRESS). Since clinical pattern, etiology, prognosis and treatment differ among these severe skin reactions, a clear diagnosis based on a comprehensive clinical examination, skin biopsy, and specific laboratory tests is necessary...
September 28, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27774826/mesenchymal-stem-cells-a-future-experimental-exploration-for-recession-of-diabetic-nephropathy
#4
Amal H Hamza, Widad M Al-Bishri, Laila A Damiati, Hanaa H Ahmed
BACKGROUND: The progresses made in stem cell therapy offer an innovative approach and exhibit great potential for the repair of damaged organs and tissues. This study was conducted with a view to find the mechanisms responsible for the effectiveness of bone marrow-derived mesenchymal stem cells (BM-MSCs) in the suppression of diabetes and experimentally-induced diabetic nephropathy. METHODS: To realize this objective, diabetic and diabetic nephropathy subject groups that underwent MSC treatment were studied through numerous biochemistry and molecular genetics analyses...
October 23, 2016: Renal Failure
https://www.readbyqxmd.com/read/27759749/acute-generalised-exanthematous-pustulosis-agep-a-potential-pitfall-for-the-acute-physician
#5
T A Cranga, M A Simpson, P Featherstone
Acute generalised exanthematous pustulosis is a rare drug-induced dermatosis with an incidence of 1-5 cases per million cases per year, characterised by the appearance of hundreds of sterile pustules over erythematous and oedematous skin. Fever and neutrophilia are usually present. It has a rapid course and usually resolves following discontinuation of the precipitating drug or as a result of topical corticosteroid treatment. A patient with AGEP, who presented with generalized pustulosis lesions after the use of Flucloxacillin for cellulitis is described, along with the management and differential diagnosis of this condition...
2016: Acute Medicine
https://www.readbyqxmd.com/read/27579754/acute-generalized-exanthematous-pustulosis-associated-with-spider-bite
#6
Laura de Mattos Milman, Giana Paula Müller, Paulo Ricardo Martins Souza, Aline Barcellos Grill, Deise Louise Bohn Rhoden, Carlos Augusto Mello-da-Silva, Gerson Vettorato
Acute generalized exanthematous pustulosis (AGEP) is an acute febrile rash, usually induced by drugs, which recently has been linked to spider bite. We report a case of a male patient, 48 years old, with an erythematous rash accompanied by fever and small non-follicular pustules. He reported previous pain in the buttock with the onset of a necrotic plaque. The lesion was compatible with spider bite of the genus Loxosceles. According to the EuroSCAR group instrument, the patient scored +10 indicating definite diagnosis of AGEP...
July 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27489427/immunohistochemical-comparison-of-il-36-and-the-il-23-th17-axis-of-generalized-pustular-psoriasis-and-acute-generalized-exanthematous-pustulosis
#7
Hyo Sang Song, Sang Jin Kim, Tae-In Park, Yong Hyun Jang, Eun-So Lee
BACKGROUND: Cutaneous pustular disorders include generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis (AGEP). OBJECTIVE: To identify differences between GPP and AGEP, here we immunohistochemically evaluated interleukin (IL)-36 and the IL-23/Th17 axis. METHODS: This retrospective comparative immunohistochemical study was completed using 11 biopsies of 11 cases of GPP and 11 biopsies of 11 cases of AGEP. Through staining with the anti-IL-36-alpha (IL-36α), anti-IL-36 receptor antagonist (IL-36Ra), anti-nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), anti-IL-23, anti-IL-17, and anti-IL-8 antibodies, main expression location and intensity were visualized in the epidermis and dermis...
August 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27477905/patch-testing-a-valuable-tool-for-investigating-non-immediate-cutaneous-adverse-drug-reactions-to-antibiotics
#8
A Pinho, I Coutinho, A Gameiro, M Gouveia, M Gonçalo
BACKGROUND: Antibiotics are among the most frequent causes of cutaneous adverse drug reactions (CADR); patch testing may be an important tool in their evaluation and management. We assessed the role of patch testing as a diagnostic tool in non-immediate CADR to antibiotics, and evaluated cross-reactivity among them. METHODS: We reviewed data from all patients with non-immediate CADR attributed to antibiotics, which were patch tested between 2000 and 2014 at our dermatology department...
August 1, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27472323/acute-generalized-exanthematous-pustulosis-pathogenesis-genetic-background-clinical-variants-and-therapy
#9
REVIEW
Laurence Feldmeyer, Kristine Heidemeyer, Nikhil Yawalkar
Acute generalized exanthematous pustulosis (AGEP) is a severe, usually drug-related reaction, characterized by an acute onset of mainly small non-follicular pustules on an erythematous base and spontaneous resolution usually within two weeks. Systemic involvement occurs in about 20% of cases. The course is mostly benign, and only in rare cases complications lead to life-threatening situations. Recent studies highlight the importance of genetic variations in interleukin-36 receptor antagonist gene (IL-36RN) in the pathogenesis of this disease...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27443659/dress-syndrome-and-acute-generalized-exanthematous-pustulosis-induced-by-antituberculosis-medications-and-moxifloxacin-case-report%C3%A2
#10
Hyunah Kim, Eun Sook Bang, Seung-Kwan Lim, Jae Myeong Lee
OBJECTIVE: To report a rare case of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by antituberculosis (TB) drugs, which progressed to acute generalized exanthematous pustulosis (AGEP) after moxifloxacin treatment. CASE SUMMARY: A 25-year-old female was hospitalized for dyspnea and dizziness. She had a history of TB and experienced rifampin-induced skin rash. She was treated for TB with moxifloxacin, isoniazid, ethambutol, and pyrazinamide...
October 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27261587/combination-of-telmisartan-with-sildenafil-ameliorate-progression-of-diabetic-nephropathy-in-streptozotocin-induced-diabetic-model
#11
Nageh Ahmed El-Mahdy, Magda El-Sayed El-Sayad, Aya Hassan El-Kadem
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in the world. Several signaling pathways are involved in the pathogenesis of DN including elevation in level of angiotensin II, formation of advanced glycation end products (AGE), activation of protein kinase c (PKC), and lipid accumulation. These pathways activate one another mutually leading to oxidative stress, increasing expression of transforming growth factor beta-1(TGF-β 1) and release of interleukins and adhesion molecules, so the aim of this study is to interrupt more than pathogenic pathway to ameliorate the progression of DN...
July 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27220475/il36rn-mutations-affect-protein-expression%C3%A2-and-function-a-basis-for-genotype-phenotype-correlation-in-pustular-diseases
#12
Marie Tauber, Elodie Bal, Xue-Yuan Pei, Marine Madrange, Amel Khelil, Houria Sahel, Akila Zenati, Mohamed Makrelouf, Khaled Boubridaa, Amel Chiali, Naima Smahi, Farida Otsmane, Bakar Bouajar, Slaheddine Marrakchi, Hamida Turki, Emmanuelle Bourrat, Manuelle Viguier, Yamina Hamel, Hervé Bachelez, Asma Smahi
Homozygous or compound heterozygous IL36RN gene mutations underlie the pathogenesis of psoriasis-related pustular eruptions including generalized pustular psoriasis, palmoplantar pustular psoriasis, acrodermatitis continua of Hallopeau, and acute generalized exanthematous pustular eruption. We identified two unreported IL36RN homozygous mutations (c.41C>A/p.Ser14X and c.420_426del/p.Gly141MetfsX29) in patients with familial generalized pustular psoriasis. We analyzed the impact of a spectrum of IL36RN mutations on IL-36 receptor antagonist protein by using site-directed mutagenesis and expression in HEK293T cells...
September 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27197323/-drug-reaction-with-eosinophilia-and-systemic-symptoms
#13
Yassaman Alipour Tehrany, Emmanuel Laffitte, Olivier Grosgurin, David Spoerl
Cutaneous drug eruptions are delayed type hypersensitivity reactions that can be potentially life threatening. Severe cutaneous adverse reactions encompass the acute generalized exanthematous pustulosis (AGEP), the drug reaction with eosinophilia and systemic symptoms (DRESS), the Stevens-Johnson syndrome (SJS) and the toxic epidermal necrolysis (TEN, synonym: Lyell syndrome). In this article, we focus on the DRESS syndrome, which associates skin eruption and systemic symptoms. Its mortality rate is estimated at 10%...
April 6, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/27057044/acute-generalized-exanthematous-pustulosis-induced-by-fexofenadine
#14
Tanvi Gupta, Vijay K Garg, Rashmi Sarkar, Anjali Madan
Acute generalized exanthematous pustulosis (AGEP) is a skin eruption, frequently drug induced and characterized by the acute development of multiple sterile minute pustules on an erythematous base. There is no case of fexofenadine-induced AGEP in literature (PubMed search). A 40-year-old female presented to us with fever and sudden onset development of multiple discrete to coalescent 1-2 mm nonfollicular pustules on an erythematous base present mainly on her trunk and upper extremities for past 2 days. She had a history of use of fexofenadine 180 mg OD for rhinitis for 2 days...
March 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27023083/prolonged-pustular-eruption-from-hydroxychloroquine-an-unusual-case-of-acute-generalized-exanthematous-pustulosis
#15
Kelly C Pearson, Dean S Morrell, Susan R Runge, Puneet Jolly
Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous eruption that often is a reaction to medications, most commonly antibiotics. Clinically, AGEP closely mimics pustular psoriasis and also is similar to subcorneal pustular dermatosis and IgA pemphigus. For clinicians, it is important to differentiate AGEP from pustular psoriasis. Acute generalized exanthematous pustulosis will have an acute drug association. Few cases have been known to be caused by hydroxychloroquine (HCQ). Proper therapeutic management of AGEP includes withdrawal of the offending agent, and resolution typically occurs within 15 days...
March 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/26848226/piperacillin-tazobactam-associated-hypersensitivity-syndrome-with-overlapping-features-of-acute-generalized-exanthematous-pustulosis-and-drug-related-rash-with-eosinophilia-and-systemic-symptoms-syndrome
#16
Tae In Kim, Ki Heon Jeong, Min Kyung Shin, Nack In Kim
Acute generalized exanthematous pustulosis (AGEP) is a rare disorder characterized by acute onset of erythematous and edematous eruptions with sterile pustules, accompanied by fever, and a self-limiting condition thought to be caused by drugs, in particular, antibiotics. Drug-related rash with eosinophilia and systemic symptoms (DRESS) syndrome is a severe adverse drug-induced reaction, characterized by a generalized skin rash associated with hypereosinophilia, lymphocytosis, and internal organ involvement...
February 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/26775791/dermoscopy-as-an-auxiliary-tool-in-the-early-differential-diagnosis-of-acute-generalized-exanthematous-pustulosis-agep-and-exanthematous-morbilliform-drug-eruption
#17
Enzo Errichetti, Enrico Pegolo, Giuseppe Stinco
No abstract text is available yet for this article.
February 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/26688759/an-uncommon-side-effect-of-bupropion-a-case-of-acute-generalized-exanthematous-pustulosis
#18
Hasan Tak, Cengiz Koçak, Gülben Sarıcı, Nazlı Dizen Namdar, Mehtap Kıdır
Acute generalized exanthematous pustulosis (AGEP) is a rare inflammatory dermatosis characterized by multiple nonfollicular pustules that occur on erythematous skin. Despite its similarity to pustular psoriasis and association with fever and leukocytosis, AGEP typically heals quickly. Etiologically, drugs and viruses have been suspected in most cases. Here, we present a case of AGEP, in a woman, that developed 1 day after starting bupropion for smoking cessation, as a rare side effect of the treatment.
2015: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/26682297/acute-generalized-exanthematous-pustulosis-associated-with-ranolazine
#19
Kurt Grelck, Noelle Stewart, Les Rosen, Sean Sukal
Acute generalized exanthematous pustulosis (AGEP) is a potentially widespread, pustular, cutaneous eruption commonly associated with drug administration. We report a case of AGEP associated with the antianginal, anti-ischemic agent ranolazine. The patient, an 83-year-old man, had a validation score of 10 out of 12 in accordance with the EuroSCAR criteria (8-12 is considered definitive), although it may have been higher had blood work been performed prior to diagnosis and treatment. After ranolazine was discontinued and a course of tapered oral prednisone was prescribed, the rash resolved with subsequent desquamation...
October 2015: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/26581932/probable-fenofibrate-induced-acute-generalized-exanthematous-pustulosis
#20
Anna E Power, Linda V Graudins, Catriona A McLean, Ingrid Hopper
PURPOSE: The case of a patient who experienced a severe adverse reaction requiring emergency treatment after a single dose of fenofibrate is described. SUMMARY: A 58-year-old woman with type 1 diabetes was hospitalized for treatment of an extensive blistering rash on the buttocks and trunk accompanied by fever, hypotension, tachycardia, neutrophilia, impaired renal function, and liver enzyme abnormalities. She reported that two days previously she had developed fever and vomiting four hours after taking her first dose of fenofibrate (145 mg)...
December 1, 2015: American Journal of Health-system Pharmacy: AJHP
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