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Stevens johnson syndrome

Andrea Núñez Ortiz, Claudio Trigo Salado, María Dolores de la Cruz Ramírez, José Manuel Herrera Justiniano, Eduardo Leo Carnerero
Mesalazine is a drug routinely used in ulcerative colitis and usually has few side effects. There have been reports of uncommon cases of severe mucocutaneous damage, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), induced by salicylates. It is important to diagnose these promptly due to the high morbidity and mortality rates. We describe the case of a 46-year-old female with ulcerative proctitis, who developed SJS following topical mesalazine use. The lesions responded well to intravenous corticosteroids after discontinuation of the drug...
June 22, 2018: Revista Española de Enfermedades Digestivas
Violeta Claudia Bojinca, Mihai Bojinca, Madalina Gheorghe, Adelina Birceanu, Cristina Ileana Iosif, Serban Mihai Balanescu, Andra Rodica Balanescu
Tumor necrosis factor inhibitors are the first biological agents used in the treatment of rheumatoid arthritis (RA) to have yielded satisfactory results in terms of clinical improvement and radiologic progression, but they are also associated with the possibility of occurrence of a number of autoimmune systemic events [drug-induced lupus (DIL), vasculitis, sarcoidosis] and localized adverse events [uveitis, psoriasis, interstitial lung disease, erythema multiforme including the major form Stevens-Johnson syndrome (SJS)]...
July 2018: Biomedical Reports
Oscar Thabouillot, Julien Le Coz, Nicolas-Charles Roche
A seven-month-old girl was referred to the emergency department (ED) after a general practitioner suspected Steven-Johnson syndrome. Actually, the diagnosis of bullous pemphigoid (BP) was made based on biopsies; BP is a rare, autoimmune skin disease involving the presence of blisters known as bullae. The child was efficiently treated with topical steroids. This case shows the importance of the ED physician's prior knowledge of BP so that a differential diagnosis with other autoimmune diseases (dermatosis, pemphigus) can be made...
June 22, 2018: Prehospital and Disaster Medicine
Samantha Bobba, Connor Devlin, Nick Di Girolamo, Denis Wakefield, Peter McCluskey, Elsie Chan, Mark Daniell, Stephanie Watson
AIMS: This study aimed to determine the incidence, clinical features and management of cicatrising conjunctivitis in Australia and New Zealand, also enabling comparison with data from the United Kingdom. METHODS: A prospective surveillance study was conducted over 17 months via the Australian and New Zealand Ophthalmic Surveillance Unit with a one-year follow-up period. Practicing ophthalmologists on the Surveillance Unit's database were asked to report recently diagnosed cases of cicatrising conjunctivitis on a monthly basis...
June 19, 2018: Eye
Virginia Velasco-Tirado, Montserrat Alonso-Sardón, Adriana Cosano-Quero, Ángela Romero-Alegría, Leire Sánchez-Los Arcos, Amparo López-Bernus, Javier Pardo-Lledías, Moncef Belhassen-García
BACKGROUND: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are serious mucocutaneous reactions. In Spain, the epidemiology and resulting expenses of these diseases are not well established. METHODOLOGY: Retrospective descriptive study using the Minimum Basic Data Set (CMBD in Spanish) in patients admitted to hospitals of the National Health System between 2010 and 2015 with a diagnosis of SJS and TEN (combination of ICD-9 codes 695.13, 695.14, and 695...
2018: PloS One
Jutamas Tankunakorn, Sirima Sawatwarakul, Vasanop Vachiramon, Kumutnart Chanprapaph
BACKGROUND/OBJECTIVE: Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN)-like lupus erythematosus is a hyperacute and life-threatening form of cutaneous lupus erythematosus. Because of its rarity, little is known about this entity. We aimed to evaluate the clinical characteristics, laboratory findings, systemic manifestations, treatments, and outcome of SJS/ TEN-like lupus erythematosus. METHODS: We conducted a chart review study from July 2002 to September 2016 of all patients diagnosed with SJS/TEN-like lupus erythematosus who presented with gradual epidermal necrolysis without clear drug or infectious culprit...
June 15, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Emily B Richard, Diana Hamer, Mandi W Musso, Tracee Short, Hollis R O'Neal
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, type IV hypersensitivity reactions of the skin and mucosa. These reactions (SJS/TEN) are frequently managed in burn units; however, no standardized guidelines exist for the treatment and management of SJS/TEN. To gain insight into current SJS/TEN management practices, a survey on admission, diagnosis, and management, was conducted across accredited burn units in the United States. A 28-item question survey on SJS/TEN management, diagnosis, and treatment practices was distributed among medical directors and co-directors of American Burn Association-verified burn centers...
June 13, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
Qian Wang, Xiao-Bing Tian, Wei Liu, Li-Xia Zhang
Elevated serum procalcitonin (PCT) level has been reported to be a diagnostic index in systemic bacterial infections, but it can also increase in some non-infectious inflammatory diseases. Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) is a rare immune-mediated cutaneous mucosal reaction which is susceptible to bacterial infections and may have elevated PCT levels. The value of serum PCT has not been assessed in series of SJS/TEN patients. We aimed to investigate the PCT levels in SJS/TEN patients with systemic bacterial infections (systemic infected group), with skin surface bacterial infections (skin surface infected group) and without infections (non-infected group), to assess whether PCT was a valuable indicator for systemic bacterial infections in SJS/TEN patients...
June 13, 2018: Journal of Dermatology
Whan B Kim, Brandon Worley, James Holmes, Elizabeth J Phillips, Jennifer Beecker, Jennifer Beecker
No abstract text is available yet for this article.
June 8, 2018: Journal of the American Academy of Dermatology
Prafulla K Maharana, Pranita Sahay, Sagnik Sen, Renu Venugopal, Jeewan S Titiyal, Namrata Sharma
PURPOSE: To describe corneal ectasia in cases of chronic Steven Johnson Syndrome (SJS) DESIGN: Prospective observational study METHOD SETTING: Institutional PATIENT: Fifteen consecutive cases of chronic SJS MAIN OUTCOME MEASURES: Best corrected distance visual acuity (BCDVA), Kmax, anterior elevation, posterior elevation, thinnest pachymetry and Sotozono severity score RESULTS: 30 eyes of fifteen patients were included. Corneal tomography using Scheimpflug technology (Pentacam-HR, Oculus GmbH) was performed...
June 8, 2018: American Journal of Ophthalmology
Satoshi Sato, Tomoka Kambe, Zenshiro Tamaki, Mihoko Furuichi, Yoji Uejima, Eisuke Suganuma, Tadamasa Takano, Kawano Yutaka
OBJECTIVES: Incidences of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, but these conditions are associated with high mortality. There have been few reports of SJS and TEN in children. The aim of this study was to evaluate the clinical features and outcomes of SJS and TEN in a group of Japanese children. METHODS: We retrospectively reviewed pediatric cases of SJS and TEN, from 2000 to 2015. RESULTS: We identified 12 cases of SJS and 3 cases of TEN, among children...
June 10, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Naoki Haratake, Tetsuzo Tagawa, Fumihiko Hirai, Gouji Toyokawa, Reiko Miyazaki, Yoshihiko Maehara
No abstract text is available yet for this article.
June 6, 2018: Journal of Thoracic Oncology
James W Antoon, Jennifer L Goldman, Samir S Shah, Brian Lee
BACKGROUND: Severe cutaneous adverse reactions are rare yet life threatening conditions. The current management and outcomes of these conditions in U.S. children is unclear. OBJECTIVES: To characterize the current management and outcomes of Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) across U.S. children's hospitals. METHODS: We performed a retrospective cohort study of children less than 18 years of age hospitalized with a primary diagnosis of SJS or TEN at 47 U...
May 30, 2018: Journal of Allergy and Clinical Immunology in Practice
Chun-Bing Chen, Ming-Ying Wu, Chau Yee Ng, Chun-Wei Lu, Jennifer Wu, Pei-Han Kao, Chan-Keng Yang, Meng-Ting Peng, Chen-Yang Huang, Wen-Cheng Chang, Rosaline Chung-Yee Hui, Chih-Hsun Yang, Shun-Fa Yang, Wen-Hung Chung, Shih-Chi Su
With the increasing use of targeted anticancer drugs and immunotherapies, there have been a substantial number of reports concerning life-threatening severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic symptoms, drug-induced hypersensitivity syndrome, and acute generalized exanthematous pustulosis. Although the potential risks and characteristics for targeted anticancer agent- and immunotherapy-induced SCAR were not well understood, these serious adverse reactions usually result in morbidity and sequela...
2018: Cancer Management and Research
Sasha A Alvarado, Diana Muñoz-Mendoza, Sami L Bahna
OBJECTIVE: Provide a brief overview of the clinical presentation, common offending agents, management, prognosis, and mortality of selected six high-risk drug rashes, namely Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), multiple drug hypersensitivity syndrome (MDH), acute generalized exanthematous pustulosis (AGEP), and drug-induced bullous pemphigoid (DIBP). DATA SOURCES: Review of published literature using PubMed, supplemented with authors' clinical experience...
May 24, 2018: Annals of Allergy, Asthma & Immunology
Jettanong Klaewsongkram, Chonlaphat Sukasem, Pattarawat Thantiworasit, Nithikan Suthumchai, Pawinee Rerknimitr, Papapit Tuchinda, Leena Chularojanamontri, Yuttana Srinoulprasert, Ticha Rerkpattanapipat, Kumutnart Chanprapaph, Wareeporn Disphanurat, Panlop Chakkavittumrong, Napatra Tovanabutra, Chutika Srisuttiyakorn
BACKGROUND: The prevention and confirmation of drug-induced severe cutaneous adverse reactions (SCARs) are difficult. OBJECTIVE: To determine the benefit of HLA-B allele pre-screening and the measurement of drug-specific interferon-gamma (IFN-γ) releasing cells in the prevention and identification of the culprit drug in SCAR patients. METHODS: A total of 160 SCAR patients were recruited from six university hospitals in Thailand over a 3-year period...
May 22, 2018: Journal of Allergy and Clinical Immunology in Practice
Sarah Zavala, Megan O'Mahony, Cara Joyce, Anthony J Baldea
The Toxic Epidermal Necrolysis-specific severity of illness score (SCORTEN) was developed to predict mortality in patients with Stevens Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Several studies have attempted to assess the accuracy of SCORTEN with mixed results. The objective of this study is to compare the predicted and actual mortality for patients with SJS/TEN admitted to a single high-volume burn center.This retrospective study included adult and pediatric patients admitted to our burn center with biopsy-confirmed SJS/TEN between February 2008 and February 2016...
December 4, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
Lusiele Guaraldo, Bianca Balzano de la Fuente Villar, Nicolle Marins Gomes Durão, Virgínia Clare Louro, Marcel de Souza Borges Quintana, André Luiz Land Curi, Elizabeth Souza Neves
Background: The purpose of this study was to estimate the frequency and describe the adverse drug reactions (ADRs) associated with the classic treatment of ocular toxoplasmosis (OT), namely sulfadiazine, pyrimethamine, corticosteroids and folinic acid. Methods: We performed a descriptive study of a prospective cohort of patients with OT treated with the classic therapy. Data were collected during medical consultations and treatment. Results: Of the 147 patients studied, 85% developed one or more ADR...
May 19, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
Benigno Monteagudo, Miguel Cabanillas, Pilar Iriarte, Aquilina Ramírez-Santos, Elvira León-Muinos, Daniel González-Vilas, Óscar Suárez-Amor
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). A 47-year-old woman was referred to our clinic for pruritic cutaneous lesions which had started 6 days earlier...
April 2018: Acta Dermatovenerologica Croatica: ADC
Cinzia Ciccacci, Cristina Politi, Sandro Mancinelli, Fausto Ciccacci, Francesca Lucaroni, Giuseppe Novelli, Maria Cristina Marazzi, Leonardo Palombi, Paola Borgiani
Objectives: Nevirapine is used in developing countries for the treatment of HIV infection, but its use is associated with rare serious adverse reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Recently, an association between rs5010528 in the human leucocyte antigen (HLA)-C locus and SJS/TEN susceptibility has been described in sub-Saharan populations. Our aim was to verify this association in a population of nevirapine-treated patients from Mozambique...
May 11, 2018: Journal of Antimicrobial Chemotherapy
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