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Stevens johnson syndrome

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https://www.readbyqxmd.com/read/29469760/the-use-of-cyclosporine-for-stevens-johnson-syndrome-toxic-epidermal-necrolysis-spectrum-at-the-university-of-louisville-a-case-series-and-literature-review
#1
Clayton D Conner, Emily McKenzie, Cindy E Owen
INTRODUCTION: Cyclosporine therapy for Stevens-Johnson syndrome-toxic epidermal necrolysis (SJSTEN) was first reported in the literature by Renfro et al. in 1989. Herein we report an additional 4 cases of SJS-TEN treated with cyclosporine. METHODS: Case information was collected retroactively at the University of Louisville Hospital in Louisville, KY. All cases had a diagnosis of SJS or TEN by a dermatologist. All patients were ≥18 years of age and treated with cyclosporine during their admission...
January 1, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469759/vaccine-induced-toxic-epidermal-necrolysis-a-case-and-systematic-review
#2
Dev Chahal, Maria Aleshin, Mamina Turegano, Melvin Chiu, Scott Worswick
BACKGROUND: Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are cutaneous hypersensitivityreactions that develop in response to specific triggers such as medications and certain infections. Vaccines, which undergo rigorous safety testing prior to use in humans, are a rare cause of SJS/TEN and little is known about the frequency of such events and corresponding pathogenesis. OBJECTIVE: Herein, we discuss a case of suspected TEN in a 19-year-old woman who received the meningococcal B vaccine (the first report of such an association) and conduct a systematic review of the associated literature...
January 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469697/generalized-bullous-fixed-drug-eruption-imitating-toxic-epidermal-necrolysis-a-case-report-and-literature-review
#3
Victoria Mitre, Danielle S Applebaum, Yasser Albahrani, Sylvia Hsu
Fixed drug eruption (FDE) is defined as sharply demarcated erythematous patches or plaques that occur secondary to systemic exposure to a causative medication. Eruptions are deemed "fixed" because upon repeated exposure they recur at previously affected sites. Generalized bullous fixed drug eruption (GBFDE) is a rare FDE variant occurring in patients with a previous history of FDE. Given the extensive cutaneous involvement and the frequent mucosal ulcerations associated with GBFDE, it is challenging to discern these lesions from Steven-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)...
July 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29466850/direct-costs-of-severe-cutaneous-adverse-reactions-in-a-tertiary-hospital-in-korea
#4
Min-Suk Yang, Ju-Young Kim, Min-Gyu Kang, Suh-Young Lee, Jae-Woo Jung, Sang-Heon Cho, Kyung-Up Min, Hye-Ryun Kang
Background/Aims: There are only a few reports on the direct costs of severe cutaneous adverse reactions (SCARs), including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN), despite the tremendous negative impact these reactions can have on patients. We estimated the direct costs of treating SCARs. Methods: Patients admitted to a tertiary teaching hospital for the treatment of SCARs from January 1, 2005 to December 31, 2010 were included...
February 23, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29445492/mycoplasma-pneumoniae-associated-fuchs-syndrome
#5
Babikir Kheiri, Nour Aljariri Alhesan, Seetharamprasad Madala, Omar Assasa, Meng Shen, Thair Dawood
Fuchs syndrome is a milder form of the Stevens-Johnson syndrome (SJS) spectrum with only mucosal involvement which can be triggered by Mycoplasma pneumonia (MP) infection. Treatment should be directed toward supportive care including ocular and mucous membrane care, fluids and nutritional support, and pain control. In addition, antibiotic and immunomodulatory treatments are discussed for this entity.
February 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29445458/stevens-johnson-syndrome-toxic-epidermal-necrolysis-associated-with-zonisamide
#6
Karina L Vivar, Kimberly Mancl, Lucia Seminario-Vidal
This report highlights zonisamide as a potential cause of serious cutaneous reactions as well as its cross-reactivity with other sulfonamides. Here, we present a case of SJS-TEN due to zonisamide, which was effectively treated with IVIg. Subsequently, the patient was transitioned to levetiracetam for seizure control.
February 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29434381/ismp-adverse-drug-reactions-influenza-vaccine-induced-stevens-johnson-syndrome-vilazodone-induced-nightmares-dabigatran-induced-pustular-eruptions-neurotoxic-and-cardiotoxic-symptoms-after-cannabis-concentrate-exposure-rosuvastatin-induced-skin-eruption
#7
Michael A Mancano
The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Mancano at ISMP, 200 Lakeside Drive, Suite 200, Horsham, PA 19044 (phone: 215-707-4936; e-mail: mmancano@temple.edu). Your report will be published anonymously unless otherwise requested...
February 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29430697/ethosuximide-induced-stevens-johnson-syndrome-beneficial-effect-of-early-intervention-with-high-dose-corticosteroid-therapy
#8
Kota Tachibana, Toshihisa Hamada, Hiroki Tsuchiya, Takashi Shibata, Kazuyasu Fujii, Katsuhiro Kobayashi, Keiji Iwatsuki
We report two rare cases of childhood epilepsy patients who developed ethosuximide-induced Stevens-Johnson syndrome (SJS). Unlike typical SJS, the initial eruption of both patients presented well-demarcated, infiltrating firm papules mainly on the cheeks and the extensor aspects of the arms (case 1), and multiple vesicles on the soles and oral aphthosis (case 2), which closely mimicked viral exanthema. We diagnosed both patients with ethosuximide-induced SJS, based on the dosing period and the positive results of drug-induced lymphocyte stimulation test...
February 11, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29426444/eyeprintpro-therapeutic-scleral-contact-lens-indications-and-outcomes
#9
Michael T B Nguyen, Vishakha Thakrar, Clara C Chan
OBJECTIVE: To describe indications and outcomes of patients fitted with the EyePrintPRO therapeutic scleral lens. METHODS: A database search of patients fitted with the EyePrintPRO from 2014 to 2016. Fourteen eyes of 10 patients were reviewed retrospectively. Patient demographics, medical and ocular history, indications for fitting, duration of wear, symptoms, and best-corrected visual acuity (BCVA) were analyzed. RESULTS: Mean age at lens fitting was 49 years (range, 21-67 years)...
February 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29421925/pediatric-stevens-johnson-syndrome-toxic-epidermal-necrolysis-halted-by-etanercept
#10
Geneviève M Gavigan, Nordau D Kanigsberg, Michele L Ramien
We report a case of an 11-year-old female with Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) overlap, most likely triggered by sulfamethoxazole-trimethoprim, who was treated with the combination of methylprednisolone, cyclosporine, and etanercept. Her condition stabilized and her skin involvement did not progress after the addition of etanercept. To our knowledge, this is the first report of etanercept for pediatric SJS/TEN.
February 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29421293/chronic-ocular-sequelae-of-stevens-johnson-syndrome-in-children-long-term-impact-of-appropriate-therapy-on-natural-history-of-disease
#11
Sayan Basu, Swapna S Shanbhag, Arjun Gokani, Richa Kedar, Chirag Bahuguna, Virender S Sangwan
PURPOSE: To describe the long-term ocular and visual morbidity in children with chronic sequelae of Stevens-Johnson Syndrome (SJS) and visual outcomes of various management strategies. DESIGN: Retrospective comparative case series. METHODS: This study included 568 eyes of 284 children with SJS who presented between 1990 and 2015. Affected eyes either received conservative therapy (n=440) or definitive management (n=128) including lid margin mucous membrane grafting (MMG), prosthetic replacement of the ocular surface ecosystem (PROSE) contact lenses, allogeneic limbal transplantation or keratoprosthesis using an algorithmic approach based on the severity of dryness and cause and extent of corneal damage...
February 5, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29410254/successful-drug-desensitization-in-patients-with-delayed-type-allergic-reactions-to-antituberculosis-drugs
#12
Krittaecho Siripassorn, Kiat Ruxrungtham, Weerawat Manosuthi
OBJECTIVE: To evaluate the outcomes of antituberculosis drug desensitization. DESIGN: This was a retrospective study. Inclusion criteria were as follows: age >18 years, documented tuberculosis infection, a previous cutaneous allergic reaction to antituberculosis drugs, and having undergone drug desensitization between January 2003 and March 2014. Definition of allergic reactions to antituberculosis drugs included (1) a temporal relationship between drug use and allergic reaction; (2) improvement of allergic reaction after drug withdrawal; (3) recurrence of allergic reaction after reintroduction of only the offending drug; and (4) absence of other causes...
February 1, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29404508/sofosbuvir-induced-steven-johnson-syndrome-in-a-patient-with-hepatitis-c-virus-related-cirrhosis
#13
Nipun Verma, Shreya Singh, Gitesh Sawatkar, Virendra Singh
Sofosbuvir is an imperative drug used in treatment regimens for hepatitis C virus (HCV). It is considered relatively safe with fewer adverse effects than other treatments. Here, we report a rare and potentially serious, dermatologic, adverse effect following the use of sofosbuvir. A 35-year-old man with genotype 3-related HCV cirrhosis presented with decompensated ascites and jaundice following 7 weeks of therapy with peginterferon alpha-2a and oral ribavirin. After peginterferon withdrawal and stabilization, oral sofosbuvir and ribavirin were started; 10 days later, he developed itching over the trunk and legs, followed by multiple papules and vesicles over an erythematous base...
January 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29400697/randomized-controlled-trial-of-tnf-%C3%AE-antagonist-in-ctl-mediated-severe-cutaneous-adverse-reactions
#14
Chuang-Wei Wang, Lan-Yan Yang, Chun-Bing Chen, Hsin-Chun Ho, Shuen-Iu Hung, Chih-Hsun Yang, Chee-Jen Chang, Shih-Chi Su, Rosaline Chung-Yee Hui, See-Wen Chin, Li-Fang Huang, Yang Yu-Wei Lin, Wei-Yang Chang, Wen-Lang Fan, Chin-Yi Yang, Ji-Chen Ho, Ya-Ching Chang, Chun-Wei Lu, Wen-Hung Chung
BACKGROUND: Cytotoxic T lymphocyte-mediated (CTL-mediated) severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are rare but life-threatening adverse reactions commonly induced by drugs. Although high levels of CTL-associated cytokines, chemokines, or cytotoxic proteins, including TNF-α and granulysin, were observed in SJS-TEN patients in recent studies, the optimal treatment for these diseases remains controversial...
February 5, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29392710/clinical-pharmacogenetics-implementation-consortium-guideline-for-hla-genotype-and-use-of-carbamazepine-and-oxcarbazepine-2017-update
#15
Elizabeth J Phillips, Chonlaphat Sukasem, Michelle Whirl-Carrillo, Daniel J Müller, Henry M Dunnenberger, Wasun Chantratita, Barry Goldspiel, Yuan-Tsong Chen, Bruce C Carleton, Alfred L George, Taisei Mushiroda, Teri Klein, Roseann S Gammal, Munir Pirmohamed
The variant allele HLA-B*15:02 is strongly associated with greater risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients treated with carbamazepine or oxcarbazepine. The variant allele HLA-A*31:01 is associated with greater risk of maculopapular exanthema, drug reaction with eosinophilia and systemic symptoms, and SJS/TEN in patients treated with carbamazepine. We summarize evidence from the published literature supporting these associations and provide recommendations for carbamazepine and oxcarbazepine use based on HLA genotypes...
February 2, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29389866/survey-of-nonprescription-medication-and-antibiotic-use-in-patients-with-stevens-johnson-syndrome-toxic-epidermal-necrolysis-and-overlap-syndrome
#16
Katherine J Sullivan, Meghan N Jeffres, Robert P Dellavalle, Robert Valuck, Heather D Anderson
Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and overlap syndrome (SJS-TEN) are rare, serious skin and mucosa break-down conditions frequently associated with antibiotic use. The role of nonprescription medications alone, or in combination with antibiotics in triggering SJS/TEN, is largely unknown. This study summarized data collected from patient surveys about nonprescription and antibiotic use prior to a SJS/TEN diagnosis. The survey was administered online to members of the U.S. SJS Foundation who had been diagnosed with SJS/TEN or were the parent of a child who had been diagnosed with SJS/TEN...
February 1, 2018: Antibiotics
https://www.readbyqxmd.com/read/29387760/acute-generalized-exanthematous-pustulosis-simulating-stevens-johnson-syndrome-toxic-epidermal-necrolysis-associated-with-the-use-of-vismodegib
#17
Oscar M Moreno-Arrones, Rosario Carrillo-Gijon, Elena Sendagorta, Luis Rios-Buceta
No abstract text is available yet for this article.
March 2018: JAAD Case Reports
https://www.readbyqxmd.com/read/29387340/stevens-johnson-syndrome-toxic-epidermal-necrolysis-and-erythema-multiforme-drug-related-hospitalisations-in-a-national-administrative-database
#18
Bernardo Sousa-Pinto, Luís Araújo, Alberto Freitas, Osvaldo Correia, Luís Delgado
Background: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme (EM) are immunologically-mediated dermatological disorders commonly triggered by drug exposure and/or other external agents. We aimed to characterise SJS/TEN- and EM-drug-related hospitalisations in a nationwide administrative database, focusing on demographic and clinical characteristics, and in the most frequently implicated drug classes. Methods: We analysed all drug-related hospitalisations with associated diagnosis of SJS/TEN or EM in Portuguese hospitals between 2009 and 2014...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29378637/staphylococcal-scalded-skin-syndrome-in-a-4-year-old-child-a-case-report
#19
P J Haasnoot, A De Vries
BACKGROUND: Staphylococcal scalded skin syndrome is an exfoliating skin disease which primarily affects children. Differential diagnosis includes toxic epidermal necrolysis, staphylococcal scalded skin syndrome, epidermolysis bullosa, and Stevens-Johnson syndrome. Staphylococcal scalded skin syndrome primarily affects children and can cause serious morbidity. CASE PRESENTATION: In this case report we highlight the case of a 4-year-old Caucasian boy. Diagnostic and therapeutic challenges are discussed...
January 29, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29378178/limbal-stem-cell-deficiency-demography-and-underlying-causes
#20
Jayesh Vazirani, Dhanyasree Nair, Swapna Shanbhag, Siva Wurity, Abhishek Ranjan, Virender Sangwan
PURPOSE: To determine the demographic features of patients affected by limbal stem cell deficiency (LSCD), and to identify the underlying causes of LSCD DESIGN: Retrospective, multi-center case series SETTING: Two large tertiary care ophthalmology hospitals SUBJECTS: Patients with a diagnosis of LSCD presenting from January 1, 2005 to December 31, 2014 METHODS: Records of patients with a clinical diagnosis of LSCD were reviewed. Demographic details and clinical features at presentation, as well as the underlying cause of LSCD (if identified) were noted...
January 26, 2018: American Journal of Ophthalmology
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