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Stevens johnson syndrome

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https://www.readbyqxmd.com/read/28208879/carbamazepine-induced-life-threatening-stevens-johnson-syndrome-and-agranulocytosis-the-maiden-case
#1
A Avinash, V Mohanbabu Amberkar, Sushil Kiran Kunder, Sharath Madhyastha, K Meenakumari
Stevens-Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine and carbamazepine are commonly implicated. Agranulocytosis is the existence of a clinically significant reduction in neutrophil count. This condition is a serious threat to the patient, as he/she is at a greater risk of contracting bacterial or fungal infections, which may prove to be fatal...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28205426/a-study-of-hla-b-15-02-in-9-different-chinese-ethnics-implications-for-carbamazepine-related-sjs-ten
#2
G J Ou, J Wang, X Ji, H Yu, L Jiang, L Li, Q Chen, P C Su, Z Liu
BACKGROUND: HLA-B*15:02 is a known biomarker for carbamazepine (CBZ)-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) in some ethnic populations. The US FDA recommends B*15:02 screening for Asian and other populations with a high prevalence of B*15:02 prior to treatment with CBZ to prevent drug-related SJS/TEN. MATERIALS AND METHODS: A total of 1607 blood samples were collected from volunteer blood donors who were ethnic minorities living in the Yunnan province of southwestern China, including 153 Yi, 193 Naxi, 167 Miao, 156 Lisu, 166 Derung, 211 Bai, 184 Hani, 198 Dai, and 179 Zhuang...
February 15, 2017: HLA
https://www.readbyqxmd.com/read/28203363/an-exploratory-factor-analysis-of-the-spontaneous-reporting-of-severe-cutaneous-adverse-reactions
#3
Manfred Hauben, Eric Hung, Wen-Yaw Hsieh
BACKGROUND: Severe cutaneous adverse reactions (SCARs) are prominent in pharmacovigilance (PhV). They have some commonalities such as nonimmediate nature and T-cell mediation and rare overlap syndromes have been documented, most commonly involving acute generalized exanthematous pustulosis (AGEP) and drug rash with eosinophilia and systemic symptoms (DRESS), and DRESS and toxic epidermal necrolysis (TEN). However, they display diverse clinical phenotypes and variations in specific T-cell immune response profiles, plus some specific genotype-phenotype associations...
January 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28203102/the-hla-a-31-01-allele-influence-on-carbamazepine-treatment
#4
REVIEW
Vincent Lai Ming Yip, Munir Pirmohamed
Carbamazepine (CBZ) is an effective anticonvulsant that can sometimes cause hypersensitivity reactions that vary in frequency and severity. Strong associations have been reported between specific human leukocyte antigen (HLA) alleles and susceptibility to CBZ hypersensitivity reactions. Screening for HLA-B*15:02 is mandated in patients from South East Asia because of a strong association with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). HLA-A*31:01 predisposes to multiple phenotypes of CBZ hypersensitivity including maculopapular exanthema, hypersensitivity syndrome, and SJS/TEN in a range of populations including Europeans, Japanese, South Koreans and Han Chinese, although the effect size varies between the different phenotypes and populations...
2017: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/28202399/the-epidemiology-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-the-uk
#5
Noel Frey, Janine Jossi, Michael Bodmer, Andreas Bircher, Susan S Jick, Christoph R Meier, Julia Spoendlin
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening mucocutaneous diseases. SJS/TEN mostly manifest as a reaction to new drug use, but little is known about their incidence and epidemiology. We conducted a large observational study on the epidemiology of SJS/TEN using data from the UK-based Clinical Practice Research Datalink. Among 551 validated SJS/TEN cases, we calculated an incidence rate of 5.76 SJS/TEN cases/million person-years between 1995 and 2013, which was consistent throughout the study period, and was highest in patients aged 1-10 years and ≥80 years...
February 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28181925/fever-in-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-pediatric-cases-laboratory-work-up-and-antibiotic-therapy
#6
Maren Paulmann, Maja Mockenhaupt
No abstract text is available yet for this article.
February 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28181259/causative-drugs-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-israel
#7
Nicola Maggio, Maria Firer, Huda Zaid, Yana Bederovsky, Mohammed Aboukaoud, Revital Gandelman-Marton, Iris Noyman, Dana Ekstein, Ilan Blatt, Eli Marom, Eyal Schwartzberg, Shoshana Israel, Arieh Ingber, Chaim Brautbar, Sara Eyal
No abstract text is available yet for this article.
February 9, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28179736/ismp-adverse-drug-reactions-acute-disseminated-intravascular-coagulation-due-to-oxaliplatin-azithromycin-induced-stevens-johnson-syndrome-acute-jugular-vein-thrombosis-with-rituximab-hemorrhagic-bullae-of-the-fingers-induced-by-furosemide
#8
Michael A Mancano
The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Mancano at ISMP, 200 Lakeside Drive, Suite 200, Horsham, PA 19044 (phone: 215-707-4936; e-mail: mmancano@temple.edu). Your report will be published anonymously unless otherwise requested...
January 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28176534/effects-of-piroxicam-on-tissue-distribution-of-sulfadimidine-in-west-african-dwarf-male-and-female-goats
#9
E I Akogwu, S A Saganuwan, P A Onyeyili
Cases of Stevens-Johnson syndrome have been increasingly reported in Nigeria by individuals who consumed meat products of animals especially goats injected sulfonamides. Hence, tissue distribution and residues of intramuscular sulfadimidine were studied in West African Dwarf (WAD) goats. Twenty goats divided into two groups of 10 each (five males; five females) weighing 10.4 ± 1.63 kg were administered intramuscular sulfadimidine (100 mg/kg body weight), and the second group was coadministered 5 mg/kg of piroxicam via right and left thigh muscle, respectively...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28153080/stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#10
Ariana Eginli, Kena Shah, Casey Watkins, Guha Krishnaswamy
No abstract text is available yet for this article.
February 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28144971/long-term-complications-of-stevens-johnson-syndrome-toxic-epidermal-necrolysis-the-spectrum-of-chronic-problems-in-patients-who-survive-an-episode-of-sjs-ten-necessitates-multi-disciplinary-follow-up
#11
REVIEW
H Y Lee, S A Walsh, D Creamer
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse reactions to drugs which cause a life-threatening eruption of mucocutaneous blistering and epithelial sloughing. The two terms describe phenotypes occurring at either end of a severity spectrum: SJS is the less extensive form (<10% body surface area (BSA) detachment), while TEN is the more extensive (>30% BSA detachment). Cases in which there is 10-30% epidermal detachment are referred to as SJS-TEN overlap. This article is protected by copyright...
February 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28137210/the-metabolism-of-methazolamide-in-immortalized-human-keratinocytes-hacat-cells
#12
Tetsuo Sasabe, Shinichiro Maeda, Kenichi Kishida, Mariko Yamano, Yoshihiro Miwa, Toshihiro Sugiyama
OBJECTIVE: Drug therapy is occasionally accompanied by an idiosyncratic severe toxicity, which occurs very rarely, but can lead to patient mortality. Methazolamide, an anti-glaucomatous agent, could cause severe skin eruptions called Stevens-Johnson syndrome/toxic epidermal necrolyis (SJS/TEN). Its precise etiology is still uncertain. In this study, the metabolism of methazolamide was investigated in immortalized human keratinocytes to reveal the possible mechanism which causes SJS/TEN...
January 27, 2017: Drug Metabolism Letters
https://www.readbyqxmd.com/read/28130024/acute-generalized-erythrodermic-pustular-psoriasis-associated-with-bupropion-naltrexone-contrave-%C3%A2
#13
Priyanka A Singh, Kerry P Cassel, Ronald M Moscati, David Eckersley
BACKGROUND: We report a case of erythrodermic pustular psoriasis associated with initiation of bupropion/naltrexone (Contrave®; Orexigen Therapeutics, La Jolla, CA) in a patient with no history of psoriasis. CASE REPORT: A 55-year-old woman was transferred to our tertiary medical center from a community hospital for possible Stevens-Johnson syndrome 3 weeks after initiation of bupropion/naltrexone. The patient was admitted to the burn unit for wound treatment and hydration...
January 24, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28108296/are-idiopathic-stevens-johnson-syndrome-toxic-epidermal-necrolysis-related-to-drugs-in-food-example-of-phenylbutazone
#14
Cynthia Haddad, Olivier Chosidow, Laurence Valeyrie-Allanore, Bijan Ghaleh, Tiphaine Legrand, Maja Mockenhaupt, Caroline Barau, Nihel Khoudour, Peggy Sekula, Pierre Wolkenstein, Anne Hulin
No abstract text is available yet for this article.
January 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28104975/antiepileptic-drugs-induced-stevens-johnson-syndrome-a-case-series
#15
Bhavi S Trivedi, Nishita H Darji, Supriya D Malhotra, Pankaj R Patel
Stevens-Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction, characterized by extensive necrosis and detachment of the epidermis from the skin. The overall incidence of SJS is seen in five cases per million people per year. SJS is typically caused by drugs and is a kind of idiosyncratic reaction. Adverse drug reactions such an SJS have a remarkable effect on patient's safety issues. We encountered nine cases of antiepileptic drug (AED)-induced SJS, specifically with carbamazepine, oxcarbazepine, and phenytoin...
December 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/28101480/spectrum-of-cutaneous-adverse-reactions-to-levetiracetam-and-human-leukocyte-antigen-typing-in-north-indian-patients
#16
Bhargavi Ramanujam, Kavish Ihtisham, Gurvinder Kaur, Shivani Srivastava, Narinder Kumar Mehra, Neena Khanna, Mahip Singh, Manjari Tripathi
BACKGROUND AND PURPOSE: Aromatic antiepileptic drugs are frequently implicated for cutaneous adverse drug reactions (cADRs); there are case-reports of even severe reactions like drug reaction eosinophilia and systemic symptoms (DRESS) and Stevens Johnson syndrome (SJS)-toxic epidermal necrolysis with Levetiracetam (LEV). Certain human leukocyte antigen (HLA)-alleles have strong association with cADRs due to specific drugs - HLA-B*15:02 and HLA-A*31:01 in Carbamazepine (CBZ)-related SJS in Han-Chinese and European populations, respectively...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28100913/genome-wide-association-study-using-the-ethnicity-specific-japonica-array-identification-of-new-susceptibility-loci-for-cold-medicine-related-stevens-johnson-syndrome-with-severe-ocular-complications
#17
Mayumi Ueta, Hiromi Sawai, Ryosei Shingaki, Yusuke Kawai, Chie Sotozono, Kaname Kojima, Kyung-Chul Yoon, Mee Kum Kim, Kyoung Yul Seo, Choun-Ki Joo, Masao Nagasaki, Shigeru Kinoshita, Katsushi Tokunaga
A genome-wide association study (GWAS) for cold medicine-related Stevens-Johnson syndrome (CM-SJS) with severe ocular complications (SOC) was performed in a Japanese population. A recently developed ethnicity-specific array with genome-wide imputation that was based on the whole-genome sequences of 1070 unrelated Japanese individuals was used. Validation analysis with additional samples from Japanese individuals and replication analysis using samples from Korean individuals identified two new susceptibility loci on chromosomes 15 and 16...
January 19, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28100272/bibliometric-analysis-of-literature-on-toxic-epidermal-necrolysis-and-stevens-johnson-syndrome-1940-2015
#18
Waleed M Sweileh
BACKGROUND: Stevens Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but fatal adverse skin reactions that affect all age groups. In order to better understand literature on this topic, we conducted a bibliometric study using Scopus database to shed light on number and growth of publications, most active countries, institutions, journals and authors involved in publishing articles in this field, citation analysis, top cited articles, international collaboration, role of medications and genetic association...
January 18, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28089075/conjunctival-impression-cytology-evaluation-of-patients-with-dry-eye-disease-using-scleral-contact-lenses
#19
Sarah La Porta Weber, Rossen Mihaylov Hazarbassanov, Alex Nasaré, José Álvaro Pereira Gomes, Ana Luisa Hofling-Lima
PURPOSE: To evaluate conjunctival impression cytology and HLADR expression changes after wearing scleral contact lenses (ScCLs) for moderate to severe dry eye disease (DED). DESIGN: Prospective interventional case series. METHODS: Forty-one eyes from 25 patients with moderate to severe DED were evaluated for Esclera ScCL treatment. Best-corrected visual acuity (BCVA) and slit-lamp findings were assessed. Impression cytology specimens were obtained from DED patients at the baseline and after wearing ScCLs for 12 months...
January 6, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28075032/-microbiological-findings-and-antibacterial-therapy-in-stevens-johnson-syndrome-toxic-epidermal-necrolysis-patients-from-a-swedish-burn-center
#20
Ilaria Tocco-Tussardi, Fredrik Huss, Benjamin Presman
BACKGROUND: Superimposed infections/sepsis are the major cause of morbidity/mortality in Stevens-Johnson syndrome/Toxic Epidermal Necrolysis (SJS/TEN). It is a delicate balance between avoiding new pharmaceuticals and prophylactically treat an incipient infection. The objective of this study was to investigate the rates and types of infection-microbials and antibiotics involved in SJS/TEN patients. METHODS: Microbiology and clinical data were collected for SJS/TEN patients admitted to our Burn Centre from January 2010 through January 2016...
January 11, 2017: Journal of Cutaneous Pathology
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