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Stevens johnson syndrome

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https://www.readbyqxmd.com/read/28108296/are-idiopathic-stevens-johnson-syndrome-toxic-epidermal-necrolysis-related-to-drugs-in-food-example-of-phenylbutazone
#1
Cynthia Haddad, Olivier Chosidow, Laurence Valeyrie-Allanore, Bijan Ghaleh, Tiphaine Legrand, Maja Mockenhaupt, Caroline Barau, Nihel Khoudour, Peggy Sekula, Pierre Wolkenstein, Anne Hulin
No abstract text is available yet for this article.
January 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28104975/antiepileptic-drugs-induced-stevens-johnson-syndrome-a-case-series
#2
Bhavi S Trivedi, Nishita H Darji, Supriya D Malhotra, Pankaj R Patel
Stevens-Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction, characterized by extensive necrosis and detachment of the epidermis from the skin. The overall incidence of SJS is seen in five cases per million people per year. SJS is typically caused by drugs and is a kind of idiosyncratic reaction. Adverse drug reactions such an SJS have a remarkable effect on patient's safety issues. We encountered nine cases of antiepileptic drug (AED)-induced SJS, specifically with carbamazepine, oxcarbazepine, and phenytoin...
December 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/28101480/spectrum-of-cutaneous-adverse-reactions-to-levetiracetam-and-human-leukocyte-antigen-typing-in-north-indian-patients
#3
Bhargavi Ramanujam, Kavish Ihtisham, Gurvinder Kaur, Shivani Srivastava, Narinder Kumar Mehra, Neena Khanna, Mahip Singh, Manjari Tripathi
BACKGROUND AND PURPOSE: Aromatic antiepileptic drugs are frequently implicated for cutaneous adverse drug reactions (cADRs); there are case-reports of even severe reactions like drug reaction eosinophilia and systemic symptoms (DRESS) and Stevens Johnson syndrome (SJS)-toxic epidermal necrolysis with Levetiracetam (LEV). Certain human leukocyte antigen (HLA)-alleles have strong association with cADRs due to specific drugs - HLA-B*15:02 and HLA-A*31:01 in Carbamazepine (CBZ)-related SJS in Han-Chinese and European populations, respectively...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28100913/genome-wide-association-study-using-the-ethnicity-specific-japonica-array-identification-of-new-susceptibility-loci-for-cold-medicine-related-stevens-johnson-syndrome-with-severe-ocular-complications
#4
Mayumi Ueta, Hiromi Sawai, Ryosei Shingaki, Yusuke Kawai, Chie Sotozono, Kaname Kojima, Kyung-Chul Yoon, Mee Kum Kim, Kyoung Yul Seo, Choun-Ki Joo, Masao Nagasaki, Shigeru Kinoshita, Katsushi Tokunaga
A genome-wide association study (GWAS) for cold medicine-related Stevens-Johnson syndrome (CM-SJS) with severe ocular complications (SOC) was performed in a Japanese population. A recently developed ethnicity-specific array with genome-wide imputation that was based on the whole-genome sequences of 1070 unrelated Japanese individuals was used. Validation analysis with additional samples from Japanese individuals and replication analysis using samples from Korean individuals identified two new susceptibility loci on chromosomes 15 and 16...
January 19, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28100272/bibliometric-analysis-of-literature-on-toxic-epidermal-necrolysis-and-stevens-johnson-syndrome-1940-2015
#5
Waleed M Sweileh
BACKGROUND: Stevens Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but fatal adverse skin reactions that affect all age groups. In order to better understand literature on this topic, we conducted a bibliometric study using Scopus database to shed light on number and growth of publications, most active countries, institutions, journals and authors involved in publishing articles in this field, citation analysis, top cited articles, international collaboration, role of medications and genetic association...
January 18, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28089075/conjunctival-impression-cytology-evaluation-of-patients-with-dry-eye-disease-using-scleral-contact-lenses
#6
Sarah La Porta Weber, Rossen Mihaylov Hazarbassanov, Alex Nasaré, José Álvaro Pereira Gomes, Ana Luisa Hofling-Lima
PURPOSE: To evaluate conjunctival impression cytology and HLADR expression changes after wearing scleral contact lenses (ScCLs) for moderate to severe dry eye disease (DED). DESIGN: Prospective interventional case series. METHODS: Forty-one eyes from 25 patients with moderate to severe DED were evaluated for Esclera ScCL treatment. Best-corrected visual acuity (BCVA) and slit-lamp findings were assessed. Impression cytology specimens were obtained from DED patients at the baseline and after wearing ScCLs for 12 months...
January 6, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28075032/-microbiological-findings-and-antibacterial-therapy-in-stevens-johnson-syndrome-toxic-epidermal-necrolysis-patients-from-a-swedish-burn-center
#7
Ilaria Tocco-Tussardi, Fredrik Huss, Benjamin Presman
BACKGROUND: Superimposed infections/sepsis are the major cause of morbidity/mortality in Stevens-Johnson syndrome/Toxic Epidermal Necrolysis (SJS/TEN). It is a delicate balance between avoiding new pharmaceuticals and prophylactically treat an incipient infection. The objective of this study was to investigate the rates and types of infection-microbials and antibiotics involved in SJS/TEN patients. METHODS: Microbiology and clinical data were collected for SJS/TEN patients admitted to our Burn Centre from January 2010 through January 2016...
January 11, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28072947/what-s-beneath-the-surface-stevens-johnson-syndrome-toxic-epidermal-necrolysis-combined-with-haemophagocytic-lymphohistiocytosis-a-case-report
#8
U M Nic Ionmhain, B R Knezevic, A Barraclough, M Lucas, M Anstey
No abstract text is available yet for this article.
January 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28066869/a-case-report-stevens-johnson-syndrome-as-an-adverse-effect-of-capecitabine
#9
Priyanka Jadhav, Jane E Rogers, Rachna Shroff
No abstract text is available yet for this article.
January 9, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28062682/genome-wide-association-study-of-nevirapine-hypersensitivity-in-a-sub-saharan-african-hiv-infected-population
#10
Daniel F Carr, Stephane Bourgeois, Mas Chaponda, Louise Y Takeshita, Andrew P Morris, Elena M Cornejo Castro, Ana Alfirevic, Andrew R Jones, Daniel J Rigden, Sam Haldenby, Saye Khoo, David G Lalloo, Robert S Heyderman, Collet Dandara, Elizabeth Kampira, Joep J van Oosterhout, Francis Ssali, Paula Munderi, Giuseppe Novelli, Paola Borgiani, Matthew R Nelson, Arthur Holden, Panos Deloukas, Munir Pirmohamed
BACKGROUND: The antiretroviral nevirapine is associated with hypersensitivity reactions in 6%-10% of patients, including hepatotoxicity, maculopapular exanthema, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). OBJECTIVES: To undertake a genome-wide association study (GWAS) to identify genetic predisposing factors for the different clinical phenotypes associated with nevirapine hypersensitivity. METHODS: A GWAS was undertaken in a discovery cohort of 151 nevirapine-hypersensitive and 182 tolerant, HIV-infected Malawian adults...
January 6, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28060039/epidemiology-and-molecular-characteristics-of-mycoplasma-pneumoniae-during-an-outbreak-of-m-pneumoniae-associated-stevens-johnson-syndrome
#11
Louise K Francois Watkins, Daniel Olson, Maureen H Diaz, Xia Lin, Alicia Demirjian, Alvaro J Benitez, Jonas M Winchell, Christine C Robinson, Kirk A Bol, Mary P Glodé, Samuel R Dominguez, Lisa A Miller, Preeta K Kutty
BACKGROUND: An increase in Mycoplasma pneumoniae-associated Stevens-Johnson syndrome (SJS) cases at a Colorado pediatric hospital led to an outbreak investigation. We describe the epidemiologic and molecular characteristics of M. pneumoniae among SJS case-patients and surrounding community members during the outbreak. METHODS: M. pneumoniae PCR-positive respiratory specimens from 5 Colorado hospitals and 4 referral laboratories underwent confirmatory PCR testing; positive specimens then underwent multilocus variable-number tandem-repeat analysis (MLVA) and macrolide resistance testing...
January 3, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28027113/methotrimeprazine-associated-stevens-johnson-syndrome-in-2-ashkenazi-jewish-patients
#12
Dina Moubayed, Anthony J Gifuni, Leon Tourian
No abstract text is available yet for this article.
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28017537/human-leukocyte-antigen-and-idiosyncratic-adverse-drug-reactions
#13
REVIEW
Toru Usui, Dean J Naisbitt
A clinical association between a specific human leukocyte antigen (HLA) allele and idiosyncratic adverse drug reactions (IADRs) is a strong indication that IADRs are mediated by the adaptive immune system. For example, it is well-established that HLA-B*15:02 and HLA-B*57:01 are associated with carbamazepine-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and abacavir-induced hypersensitivity/flucloxacillin-induced liver injury, respectively. Drug-specific T-cells whose response is restricted by specific HLA risk alleles have been detected from IADR patients, also suggesting an adaptive immune pathogenesis...
November 18, 2016: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28011147/interleukin-15-is-associated-with-severity-and-mortality-in-stevens-johnson-syndrome-toxic-epidermal-necrolysis
#14
Shih-Chi Su, Maja Mockenhaupt, Pierre Wolkenstein, Ariane Dunant, Sabine Le Gouvello, Chun-Bing Chen, Olivier Chosidow, Laurence Valeyrie-Allanore, Teresa Bellon, Peggy Sekula, Chuang-Wei Wang, Martin Schumacher, Sylvia H Kardaun, Shuen-Iu Hung, Jean-Claude Roujeau, Wen-Hung Chung
Early diagnosis and prognosis monitoring for Stevens-Johnson syndrome (SJS)/ toxic epidermal necrolysis (TEN) still remain a challenge. This study aims to explore any cytokine/chemokine with prognostic potential in SJS/TEN. Through screening a panel of 28 serological factors, IL-6, IL-8, IL-15, TNF-α, and granulysin were upregulated in SJS/TEN patients and selected for the further validation in total 155 SJS/TEN patients, including 77 from Taiwan and 78 from RegiSCAR (the Registry of Severe Cutaneous Adverse Reactions)...
December 20, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28008656/human-herpesvirus-6-hhv-6b-lymphadenitis-in-dress-syndrome-a-lymphoma-mimic
#15
Steven Johnson, Stephanie Mathews, David S Hudnall
AIMS: Lymphadenopathy, hematologic abnormalities, and constitutional symptoms are among the non-specific manifestations seen in drug rash with eosinophilia and systemic symptoms (DRESS), an uncommon but potentially fatal cutaneous adverse drug reaction. The ubiquitous human herpesvirus 6 (HHV-6) plays a unique role in the pathogenesis of DRESS, with emerging data suggesting that reactivation occurs in most cases and contributes to the clinical manifestations, including lymphadenopathy...
December 23, 2016: Histopathology
https://www.readbyqxmd.com/read/28006882/erythema-exsudativum-multiforme-induced-by-a-taurine-containing-energy-drink
#16
Antigona Mithat Begolli Gerqari, Mybera Ferizi, Sadije Halimi, Aferdita Daka, Syzana Hapciu, Ilir Mithat Begolli, Mirije Begolli, Idriz Hysen Gerqari
Erythema exsudativum multiforme is an immunologically mediated skin condition caused by viruses, bacteria, food, and drugs. There are different forms, and depending on the severity of the disease there is a major and minor form. Whereas the minor form passes without consequences, the major form and Stevens-Johnson syndrome affect the mucosa and may result in death. The disease affects all age groups but is more often observed in young individuals. Typical signs of the disease are skin lesions termed herpes iris...
December 2016: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/27994401/streptococcus-agalactiae-endophthalmitis-in-boston-keratoprosthesis-in-a-patient-with-steven-johnson-syndrome
#17
Humoud M Al-Otaibi, Mohammed Talea, Omar Kirat, Donald U Stone, William N May, Igor Kozak
A 25-year-old Syrian male with a previous episode of Stevens-Johnson syndrome with bilateral corneal cicatrization previously underwent surgery for Type 1 Boston Keratoprosthesis (K-Pro). Sixteen months after the K-Pro surgery, the patient presented with decreased vision to hand motion and microbial keratitis of the graft around the K-Pro with purulent discharge. Corneal scrapings were nonrevealing. B-scan in 3 days showed increased debris in the vitreous cavity and thickened retinochoroidal layer. Intravitreal tap and injections of vancomycin and ceftazidime were performed...
October 2016: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/27992698/effects-of-hydroxychloroquine-on-cutaneous-lupus-erythematosus-a-multi-center-double-blind-randomized-parallel-group-trial
#18
N Yokogawa, H Eto, A Tanikawa, T Ikeda, K Yamamoto, T Takahashi, H Mizukami, T Sato, N Yokota, F Furukawa
Objectives To assess the efficacy and tolerability of hydroxychloroquine (HCQ) in a phase III clinical trial conducted in Japan Methods A double-blind randomized parallel-group clinical trial was performed. This was a baseline-controlled study and the group differences were evaluated in an exploratory analysis. A total of 103 patients with active CLE (CLASI activity score ≥4) were included. Patients were randomized (3:1) to receive HCQ or placebo in the 16-week double-blind period, and all patients were given HCQ in the following 36-week single-blind period...
December 19, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27990674/nationwide-survey-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-children-in-the-united-states
#19
Yusuke Okubo, Kotaro Nochioka, Marcia A Testa
Although Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious, life-threatening reactions to drug therapies, no efforts have been made to investigate the comprehensive change in epidemiology with respect to age, sex, and race and ethnicity in children. The risk of death was 0.3% to 1.5%, and the highest hospitalization rates were in children 15 to 19 years of age, boys, and black children. The highest proportions of hospitalizations were children with very low household income, those with private insurance, and those treated at large urban teaching hospitals in the West...
December 19, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27979020/antiepilepsy-drugs-and-the-immune-system
#20
REVIEW
Neetu Godhwani, Sami L Bahna
OBJECTIVE: To alert physicians about the peculiar adverse effects of antiepilepsy drugs (AEDs) on the immune system. DATA SOURCES: PubMed literature during the past 25 years. STUDY SELECTIONS: Reports and review articles on the hypersensitivities of AEDs and their effect on immunity. RESULTS: AEDs have significant effects on the immune system in the form of hypersensitivity or immune suppression. IgE-mediated reactions can be urticaria, angioedema, bronchospasm, or anaphylaxis...
December 2016: Annals of Allergy, Asthma & Immunology
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