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Stevens johnson syndrome

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https://www.readbyqxmd.com/read/28547534/a-cross-sectional-comparative-study-on-chronic-ocular-manifestations-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-chinese-eyes-a-15-year-case-series
#1
Loraine L W Chow, Alex L K Ng, Sharon S W Chow, Bonnie N K Choy, Kendrick C Shih, Ian Y H Wong, Johnny C Y Chan, Jimmy S M Lai
PURPOSE: To compare the chronic ocular manifestations in Stevens-Johnson syndrome and toxic epidermal necrolysis patients from a 15-year cohort. METHODS: All SJS and TEN patients admitted to our burn intensive care unit between 1999 and 2014 were invited for assessment. Slit-lamp examination was performed, and ocular condition was graded according to the Sotozono scoring System, which depended on the extent of cornea, conjunctiva and lid involvement. Tear osmolarity was also measured...
May 25, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28542914/efficacy-and-adverse-events-of-oral-isotretinoin-for-acne-a-systematic-review
#2
REVIEW
I A Vallerand, R T Lewinson, M S Farris, C D Sibley, M L Ramien, A G M Bulloch, S B Patten
Despite many years of clinical use of isotretinoin, a comprehensive review of evidence for isotretinoin therapy in acne patients is lacking. We searched MEDLINE, EMBASE, Cochrane Central, relevant webpages and bibliographies for randomized controlled trials for acne evaluating isotretinoin vs control (placebo or other therapy). Data were extracted and summarized descriptively. Eleven trials were identified (total n=760 patients randomized), containing mostly males. Mean treatment ages ranged from 18 to 47.9 years and participants generally had moderate-severe acne...
May 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28542263/inflammatory-biomarkers-as-predictors-of-heart-failure-in-women-without-obstructive-coronary-artery-disease-a-report-from-the-nhlbi-sponsored-women-s-ischemia-syndrome-evaluation-wise
#3
Ahmed AlBadri, Kha Lai, Janet Wei, Sofy Landes, Puja K Mehta, Quanlin Li, Delia Johnson, Steven E Reis, Sheryl F Kelsey, Vera Bittner, George Sopko, Leslee J Shaw, Carl J Pepine, C Noel Bairey Merz
BACKGROUND: Women with signs and symptoms of ischemia, no obstructive coronary artery disease (CAD) and preserved left ventricular ejection fraction (EF) often have diastolic dysfunction and experience elevated rates of major adverse cardiac events (MACE), including heart failure (HF) hospitalization with preserved ejection fraction (HFpEF). We evaluated the predictive value of inflammatory biomarkers for long-term HF hospitalization and all-cause mortality in these women. METHODS: We performed a cross-sectional analysis to investigate the relationships between inflammatory biomarkers [serum interleukin-6 (IL-6), C-reactive protein (hs-CRP) and serum amyloid A (SAA)] and median of 6 years follow-up for all-cause mortality and HF hospitalization among women with signs and symptoms of ischemia, non-obstructive CAD and preserved EF...
2017: PloS One
https://www.readbyqxmd.com/read/28541871/the-effect-of-comorbidities-on-overall-mortality-in-stevens-johnson-syndrome-an-analysis-of-the-nationwide-inpatient-sample
#4
Harib Ezaldein, Mariam Totonchy, Christopher Chow, Andre Samuel, Alessandra Ventura
BACKGROUND: Stevens Johnson Syndrome (SJS) is a life threatening skin condition with an overall mortality rate of 5%. Although the causes and pathology of the disease have been well studied, the factors that significantly contribute to mortality remain unclear. OBJECTIVE: To determine relevant risk factors that increase the likelihood of inpatient mortality after diagnosis of SJS. METHODS: A retrospective cohort study of the 2010-2011 Healthcare Costs and Utilization Project (HCUP) Nationwide InpatientSample (NIS) database was conducted...
April 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28533933/negative-wound-pressure-therapy-is-safe-and-useful-in-pediatric-burn-patients
#5
Yanhan Ren, Philip Chang, Robert L Sheridan
INTRODUCTION: Negative Pressure Wound Therapy (NPWT) has proven to be a powerful tool in facilitating healing of difficult wounds of a variety of etiologies. The pediatric experience with NPWT has been limited due to concerns about vascular compression and pain associated with treatment. METHOD: A retrospective review was performed to evaluate the therapeutic effect of NPWT on children with difficult wounds due to burns or soft-tissue trauma. NPWT was instituted in the operating room under general anesthesia using a commercially available system...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/28526303/the-use-of-biobrane-%C3%A2-for-wound-coverage-in-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#6
Alan D Rogers, Erin Blackport, Robert Cartotto
INTRODUCTION: Published experience describing the use of Biobrane(®) for wound management in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS-TEN) is limited to case reports and case series involving ten or fewer patients. We have used Biobrane(®) in the care of SJS-TEN since 2000, and the purpose of this study was to review our experience with the application of Biobrane(®) for wound coverage in SJS-TEN. METHODS: A retrospective review of all cases of SJS-TEN admitted to an adult regional ABA-verified burn center between January 1, 2000 and June 1, 2015 was conducted...
May 16, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28524050/cutaneous-adverse-effects-during-ipilimumab-treatment-for-metastatic-melanoma-a-prospective-study
#7
Emi Dika, Giulia Maria Ravaioli, Pier Alessandro Fanti, Bianca Maria Piraccini, Martina Lambertini, Marco Adriano Chessa, Carlotta Baraldi, Simone Ribero, Ardizzoni Andrea, Barbara Melotti, Annalisa Patrizi
Ipilimumab is an immunomodulatory antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), which is administered to patients with advanced melanoma, with a proven positive effect on overall survival. The cutaneous adverse effects (AEs) of ipilimumab are relatively frequent, although described as usually mild and rarely life threatening. To describe a three-year experience of a single institute in detecting and managing cutaneous AEs. A cohort of patients (n = 41) treated with ipilimumab (3 mg/kg/three weeks) for metastatic melanoma, from 2013 to 2016, was investigated for adverse cutaneous events...
May 19, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28515564/delayed-stevens-johnson-syndrome-secondary-to-the-use-of-lamotrigine-in-bipolar-mood-disorder
#8
Kunal Kishor Jha, Durgesh Prasad Chaudhary, Tshristi Rijal, Semanta Dahal
Lamotrigine is a mood-stabilizing drug used in maintenance treatment of bipolar I disease. There are adverse effects with lamotrigine such as a headache, blurred vision, diplopia, somnolence, ataxia, dizziness, rash, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis. SJS is a life-threatening, blistering mucocutaneous disease. SJS is characterized by the presence of flat, diffuse erythematous maculopapular rashes with the involvement of <10% of the body surface area. Standard trigger is drugs including anticonvulsants, antibiotics, and Mycoplasma pneumoniae infection...
March 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28511829/suicidal-behaviors-in-the-dermatology-patient
#9
Madhulika A Gupta, Daiana R Pur, Branka Vujcic, Aditya K Gupta
An assessment of suicidal behaviors in the dermatology patient may be necessary in several situations: (1) in the presence of psychiatric comorbidity (major depressive disorder, body dysmorphic disorder, substance use disorder, posttraumatic stress disorder), encountered in up to 30% of dermatology patients; (2) when dermatologic symptoms ("dysmorphophobia," dermatitis artefacta) represent psychiatric pathologic conditions; (3) when psychosocial stressors (bereavement, interpersonal violence) increase the risk of suicidal behavior and exacerbate stress-reactive dermatoses (psoriasis, acne); (4) in the presence of high disease burden (chronicity, increased disease severity); (5) in instances of significant pruritus or chronic sleep disruption; (6) in the presence of facial lesions or facial scarring; (7) when social exclusion or feelings of alienation arise secondary to the skin disorder; (8) with use of medications (retinoids, biologics) for which suicidal behavior has been implicated as a possible side effect; and (9) when treating psychiatric patients experiencing a serious reaction to psychotropic medications (eg, Stevens-Johnson syndrome and anticonvulsants)...
May 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28509689/risk-factors-of-allopurinol-induced-severe-cutaneous-adverse-reactions-in-a-thai-population
#10
Niwat Saksit, Wichittra Tassaneeyakul, Nontaya Nakkam, Parinya Konyoung, Usanee Khunarkornsiri, Pansu Chumworathayi, Chonlaphat Sukasem, Sumitra Suttisai, Napacha Piriyachananusorn, Pawinee Tiwong, Nathorn Chaiyakunapruk, Kittisak Sawanyawisuth, Ticha Rerkpattanapipat, Wongwiwat Tassaneeyakul
BACKGROUND: Allopurinol is one of the most common causes of severe cutaneous adverse drug reactions (SCARs) including drug reactions with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). This study identified the risk factors associated with the development of allopurinol-induced SCARs in a Thai population. PATIENTS AND METHODS: Eighty-six allopurinol-induced SCARs (i.e. 19 DRESS and 67 SJS/TEN) and 182 allopurinol-tolerant patients were enrolled in the study...
May 15, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28508974/pauci-immune-crescentic-glomerulonephritis-associated-with-use-of-trimethoprim-sulfamethoxazole
#11
Shruti S Hegde, Vanesa Bijol, Bertrand L Jaber
Drug-induced pauci-immune crescentic glomerulonephritis has been described with several agents, including propylthiouracil, minocycline, D-penicillamine, and hydralazine. We present the case of a 60-year-old man who presented with rapidly progressive glomerulonephritis in the setting of recent use of trimethoprim-sulfamethoxazole complicated by the development of the Stevens-Johnson syndrome, and was found to have biopsy-proven pauci-immune crescentic glomerulonephritis and undetectable anti-neutrophilic cytoplasmic antibodies...
November 2016: CEN Case Reports
https://www.readbyqxmd.com/read/28508417/score-of-toxic-epidermal-necrosis-predicts-the-outcomes-of-pediatric-epidermal-necrolysis
#12
Jennifer Sorrell, Lisa Anthony, Alfred Rademaker, Steven M Belknap, Shields Callahan, Dennis P West, Amy S Paller
BACKGROUND/OBJECTIVES: Epidermal necrolysis (Stevens-Johnson syndrome and toxic epidermal necrolysis) includes immune-mediated, life-threatening inflammatory blistering disorders that can affect children. The Score of Toxic Epidermal Necrosis (SCORTEN) tool has accurately predicted the outcome of these disorders in adults but has not been tested in children. METHODS: We performed a retrospective chart review to compare the accuracy of the adult SCORTEN tool with that of two modifications tailored to children in predicting disease outcome...
May 16, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28504871/pollination-and-breeding-system-of-the-enigmatic-south-african-parasitic-plant-mystropetalon-thomii-mystropetalaceae-rodents-welcome-but-not-needed
#13
Nina Hobbhahn, Sandy-Lynn Steenhuisen, Toni Olsen, Jeremy J Midgley, Steven D Johnson
Unrelated plants adapted to particular pollinator types tend to exhibit convergent evolution in floral traits. However, inferences about likely pollinators from "pollination syndromes" can be problematic due to trait overlap among some syndromes and unusual floral architecture in some lineages. An example is the rare South African parasitic plant Mystropetalon thomii (Mystropetalaceae), which has highly unusual brush-like inflorescences that exhibit features of both bird- and rodent-pollination syndromes. We used camera traps to record flower visitors, quantified floral spectral reflectance and nectar and scent production, experimentally determined self-compatibility and breeding system, and studied pollen dispersal using fluorescent dyes...
May 15, 2017: Plant Biology
https://www.readbyqxmd.com/read/28499754/methotrexate-induced-epidermal-necrosis-a-case-series-of-24-patients
#14
Ting-Jui Chen, Wen-Hung Chung, Chun-Bing Chen, Rosaline Chung-Yee Hui, Yu-Huei Huang, Yueh-Tsung Lu, Chang-Wei Wang, Kuo-Hsien Wang, Li-Cheng Yang, Shuen-Iu Hung
BACKGROUND: Methotrexate-induced epidermal necrosis (MEN) is a rare but life-threatening cutaneous reaction that mimics Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). OBJECTIVES: To investigate the clinicopathology, risk factors, and prognostic factors of MEN. METHODS: We enrolled 24 patients with MEN and 150 controls and analyzed the demographics, pathology, and plasma concentrations of methotrexate (MTX). RESULTS: Patients with MEN showed extensive skin necrosis (mean, 33...
May 10, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28499410/comparison-of-the-acute-ocular-manifestations-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-chinese-eyes-a-15-year-retrospective-study
#15
Loraine L W Chow, Kendrick C Shih, Johnny C Y Chan, Jimmy S M Lai, Alex L K Ng
BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening conditions that initially affect the skin and mucous membranes. The aim of this study was to compare the acute ocular manifestations between SJS and TEN. METHODS: The initial presenting ophthalmic records of patients with either SJS (<30% body surface area involvement) or TEN (> = 30% involvement), who were treated at one tertiary burn center in Hong Kong between 1999 and 2014, were retrospectively analyzed and compared...
May 12, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28492593/eruptive-melanocytic-nevi-during-azathioprine-therapy-for-antisynthetase-syndrome
#16
Stephanie A Steinweg, Christian R Halvorson, Grace F Kao, Sridhar Dronavalli
Eruptive melanocytic nevi (EMN) are rare multiple benign melanocytic nevi that develop within a few months. The phenomenon has been associated with a variety of dermatologic and systemic conditions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, epidermolysis bullosa, Addison disease, human immunodeficiency virus infection, and internal malignancy, among others. It also is commonly attributed to medications, particularly immunosuppressive and chemotherapeutic agents. We report a case of EMN in a 50-year-old man undergoing azathioprine therapy for antisynthetase syndrome...
April 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28492010/a-case-of-stevens-johnson-syndrome-with-gross-hematuria
#17
Lifang Hu, Xinzhen Lu, Jiping Xia, Maihua Hou
No abstract text is available yet for this article.
June 2016: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28488978/stevens-johnson-syndrome-toxic-epidermal-necrolysis-and-treatment-with-a-biologic-a-case-report
#18
Ian Chong, Alice Chao
INTRODUCTION: One of the most dangerous dermatologic emergencies is Stevens-Johnson Syndrome (SJS)/toxic epidermal necrolysis (TEN). Although a rare disease, it can often lead to significant mortality. CASE PRESENTATION: In this case report, we present a 77-year-old man who developed a sloughing rash that was secondary to a nonsteroidal anti-inflammatory drug. In addition to the recommended supportive care, the patient was treated with etanercept, a new, less commonly used intervention...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28483310/severe-delayed-cutaneous-and-systemic-reactions-to-drugs-a-global-perspective-on-the-science-and-art-of-current-practice
#19
Jonathan Grant Peter, Rannakoe Lehloenya, Sipho Dlamini, Kimberly Risma, Katie D White, Katherine C Konvinse, Elizabeth J Phillips
Most immune-mediated adverse drug reactions (IM-ADRs) involve the skin, and many have additional systemic features. Severe cutaneous adverse drug reactions (SCARs) are an uncommon, potentially life-threatening, and challenging subgroup of IM-ADRs with diverse clinical phenotypes, mechanisms, and offending drugs. T-cell-mediated immunopathology is central to these severe delayed reactions, but effector cells and cytokines differ by clinical phenotype. Strong HLA-gene associations have been elucidated for specific drug-SCAR IM-ADRs such as Stevens-Johnson syndrome/toxic epidermal necrolysis, although the mechanisms by which carriage of a specific HLA allele is necessary but not sufficient for the development of many IM-ADRs is still being defined...
May 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28482929/ivermectin-induced-steven-johnsons-syndrome-case-report
#20
Desmond Aroke, Diego Nitcheu Tchouakam, Alexis Tazinya Awungia, Sylvester Yari Mapoh, Stewart Ndutard Ngassa, Benjamin Momo Kadia
BACKGROUND: Stevens-Johnson syndrome is one of the manifestations of mucocutaneous adverse drug reactions. Although antimicrobials are responsible for greater than 50% of these adverse drug reactions, there is no documented case implicating ivermectin as the culprit. A 38 year old adult Cameroonian male presented to our health facility with facial rash, painful oral sores, black eschars on lips and red tearing eyes 3 days following ingestion of ivermectin received during a nationwide anti-filarial campaign...
May 8, 2017: BMC Research Notes
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