keyword
MENU ▼
Read by QxMD icon Read
search

Epigenerics or methylation or hypermethylation or hypomethylation or HIV

keyword
https://www.readbyqxmd.com/read/28532134/assessing-the-efficacy-of-second-line-antiretroviral-treatment-for-hiv-patients-failing-first-line-antiretroviral-therapy-in-iran-a-cohort-study
#1
Mehrnaz Rasooli-Nejad, Maryam Khazaee-Pool, Ladan Abbasian, Zahra Bayat Jozani, Sara Ahsani-Nasab, Banafsheh Moradmand Badie, Afsaneh Pargar, Gholamreza Esmaeeli Djavid
There are limited documents about HIV patients switched to second-line antiretroviral therapy (ART) in resource-limited countries. We aimed to assess the efficacy of second-line ART for HIV patients following first-line ART failure. This was a cohort study of HIV/AIDS patients with first-line ART treatment failure switched to second-line ART between January 2004 and March 2014, who followed for at least 12 months after switching. Fifty of studied patients (85%) were treated with regimens containing lopinavir/ritonavir (Kaletra) and nine of them (15%) treated with other regimes...
April 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28532127/investigation-of-free-standing-plasmonic-mesoporous-ag-cmk-8-nafion-composite-membrane-for-the-removal-of-organic-pollutants-with-254-nm-uv-irradiation
#2
Chuan Ming Tseng, Hsin Liang Chen, Sz Nian Lai, Ming Shiung Chen, Chien Jung Peng, Chia Jui Li, Wei Hsuan Hung
"Carbon-based material" has demonstrated a great potential on water purification due to its strong physical adsorption to organic pollutants in the water. Three-dimensional cubic ordered mesoporous carbon (CMK-8), one of the well-known ordered mesoporous carbons, was prepared by using nanocasting method with mesoporous silica (KIT-6) as the template. In this study, CMK-8 blended with Nafion polymer to form a free-standing mesoporous CMK-8-Nafion composite membrane. The synthesis of high crystallinity CMK-8 was characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM)...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28532118/facile-synthesis-of-polymeric-fluorescent-organic-nanoparticles-based-on-the-self-polymerization-of-dopamine-for-biological-imaging
#3
Yingge Shi, Ruming Jiang, Meiying Liu, Lihua Fu, Guangjian Zeng, Qing Wan, Liucheng Mao, Fengjie Deng, Xiaoyong Zhang, Yen Wei
Polymeric fluorescent organic nanoparticles (polymer-FONs) have raised considerable research attention for biomedical applications owing to their advantages as compared with fluorescent inorganic nanoparticles and small organic molecules. In this study, we presented an efficient, facile and environment-friendly strategy to produce polymer-FONs, which relied on the self-polymerization of dopamine and polyethyleneimine (PEI) in rather mild conditions. To obtain the final polymer-FONs, aldehyde group-containing copolymers (named as poly(UA-co-PEGMA)) were synthesized by reversible addition-fragmentation chain-transfer polymerization using polyethylene glycol methyl ether methacrylate (PEGMA) and 1-undecen-10-al (UA) as monomers...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532077/preparation-of-robust-braid-reinforced-poly-vinyl-chloride-ultrafiltration-hollow-fiber-membrane-with-antifouling-surface-and-application-to-filtration-of-activated-sludge-solution
#4
Zhuang Zhou, Saeid Rajabzadeh, Lifeng Fang, Taro Miyoshi, Yuriko Kakihana, Hideto Matsuyama
Braid-reinforced hollow fiber membranes with high mechanical properties and considerable antifouling surface were prepared by blending poly(vinyl chloride) (PVC) with poly(vinyl chloride-co-poly(ethylene glycol) methyl ether methacrylate) (poly(VC-co-PEGMA)) copolymer via non-solvent induced phase separation (NIPS). The tensile strength of the braid-reinforced PVC hollow fiber membranes were significantly larger than those of previously reported various types of PVC hollow fiber membranes. The high interfacial bonding strength indicated the good compatibility between the coating materials and the surface of polyethylene terephthalate (PET)-braid...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532075/can-pei-microgels-become-biocompatible-upon-betainization
#5
Nurettin Sahiner, Sahin Demirci
Polyethylene imine (PEI) microgels prepared via micro emulsion polymerization technique were treated with 1,3-propane sultone to obtained betainized PEI (b-PEI) microgels. The betainization reaction generated zwitterions on PEI microgel that are positive charges from quarternized amine groups of PEI, and the newly formed negative charges from SO3(-) groups from the modifying agent, 1,3-propane sultone offered interesting properties. The smaller size of b-PEI microgels that are obtained by simple filtration were increased with betainization from 512±14 to 1114±86nm...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531987/electrospinning-of-thermoplastic-carboxymethyl-cellulose-poly-ethylene-oxide-nanofibers-for-use-in-drug-release-systems
#6
Akbar Esmaeili, Mahsa Haseli
Polymeric delivery systems using electrospun nanofibers have been developed for many applications, notably for drug delivery and tissue engineering in the healthcare industry. In this study, a nanofiber drug carrier was fabricated via two different electrospinning processes, blend and coaxial, using a new degradable thermoplastic carboxymethyl cellulose (TCMC) and poly(ethylene oxide) (PEO). The TCMC was synthesized by graft copolymerization with methyl acrylate. Tetracycline hydrochloride served as a drug model incorporated within these nanofibers and their performance as a drug-carrier scaffold was evaluated...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531980/self-assembled-nanomicelles-of-damnacanthal-loaded-amphiphilic-modified-chitosan-preparation-characterization-and-cytotoxicity-study
#7
Pakin Sukamporn, Seung Joon Baek, Wandee Gritsanapan, Suwabun Chirachanchai, Thararat Nualsanit, Pleumchitt Rojanapanthu
Damnacanthal (Dam) is a phytochemical with many pharmacological properties including anticancer activity. However, its hydrophobicity, poor bioavailability and stability limit its application in many biological approaches. In this study, Dam nanomicelles as an emerging platform were developed to overcome limitations. The deoxycholic and poly(ethylene glycol) methyl ether grafted chitosan (DCA-CS-mPEG) was synthesized and characterized by FTIR and (1)H NMR and the degree of substitution (DS) was determined by elemental analysis (EA)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531953/priority-pesticides-abatement-by-advanced-water-technologies-the-case-of-acetamiprid-removal-by-ozonation
#8
A Cruz-Alcalde, C Sans, S Esplugas
With the aim of exploring treatment alternatives for priority insecticide acetamiprid (ACMP) abatement, the removal of this compound from water by ozonation was studied for the first time, paying special attention to the kinetic, mechanistic and toxicological aspects of the process. The second order rate constants of reactions between ACMP and both molecular ozone (O3) and hydroxyl radicals (OH) were determined to be 0.25M(-1)s(-1) and 2.1·10(9)M(-1)s(-1), respectively. On the basis of kinetic results, the degradation of ACMP during ozonation could be well-explained by the reactivity of this pesticide with OH...
May 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531863/biodiesel-production-from-spirulina-microalgae-feedstock-using-direct-transesterification-near-supercritical-methanol-condition
#9
Hamed Mohamadzadeh Shirazi, Javad Karimi-Sabet, Cyrus Ghotbi
Microalgae as a candidate for production of biodiesel, possesses a hard cell wall that prevents intracellular lipids leaving out from the cells. Direct or in situ supercritical transesterification has the potential for destruction of microalgae hard cell wall and conversion of extracted lipids to biodiesel that consequently reduces the total energy consumption. Response surface methodology combined with central composite design was applied to investigate process parameters including: Temperature, Time, Methanol-to-dry algae, Hexane-to-dry algae, and Moisture content...
April 21, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28531769/increases-in-prescription-opioid-injection-abuse-among-treatment-admissions-in-the-united-states-2004-2013
#10
Christopher M Jones, Aleta Christensen, R Matthew Gladden
BACKGROUND: The 2015 HIV outbreak in Indiana associated with prescription opioid injection coupled with rising rates of hepatitis C, especially in areas with long-standing opioid abuse, have raised concerns about prescription opioid injection. However, research on this topic is limited. We assessed trends in treatment admissions reporting injection, smoking, and inhalation abuse of prescription opioids and examined characteristics associated with non-oral routes of prescription opioid abuse in the U...
May 16, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28531648/cationic-surfactant-blocks-radical-inhibiting-sites-on-silica
#11
Tan Zhang, Frank D Blum
Surfactant-catalyzed room-temperature radical polymerization of methyl methacrylate (MMA) was conducted in the presence of fumed silica nanoparticles and water. Three types of surfactants, cationic (CTAB), nonionic (Triton X-100) or anionic (SDS), were used to catalyze the decomposition of the initiator, 2,2'-azobisisobutyronitrile (AIBN). The surfactant-catalyzed decomposition rate constant for AIBN at room temperature was found to be independent of the surfactant type. However, the rates of polymerization of the MMA emulsion gels at room temperature were found to depend on the types of surfactant with: cationic>nonionic>anionic...
May 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28531643/lipid-based-nutrient-supplements-containing-vitamins-and-minerals-attenuate-renal-electrolyte-loss-in-hiv-aids-patients-starting-antiretroviral-therapy-a-randomized-controlled-trial-in-zambia
#12
D Munkombwe, T L Muungo, C Michelo, P Kelly, S Chirwa, S Filteau
BACKGROUND & AIMS: Advanced HIV infection combined with undernutrition and antiretroviral therapy (ART) places HIV/AIDS patients at high risk of electrolyte abnormalities and increased morbidity and mortality. Here, in a sub-study of a large published randomized trial, we evaluated if nutritional supplements will help curtail renal electrolyte loss in HIV/AIDS patients starting ART. METHODS: 130 malnourished HIV-positive patients referred for ART received lipid-based nutrient supplements alone (LNS, n = 63) or together with vitamins and minerals (LNS-VM, n = 67)...
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531558/accumulation-translocation-and-conversion-of-six-arsenic-species-in-rice-plants-grown-near-a-mine-impacted-city
#13
Li Ma, Lin Wang, Yuyu Jia, Zhaoguang Yang
Paddy rice (Oryza sativa L.) as the staple food in China was found to be efficient in accumulating arsenic (As) due to cultivated in flooded paddy soil. Uptake and translocation of As in rice plant depended on the As species. In this work, rice plant samples including roots, straws and grains as well as rhizosphere soils were collected from paddy fields near Changsha, a mine impacted city in Southern China. The total As concentrations in the collected samples were observed in the descending order as root > soil > straw > grain...
May 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28531553/hiv-1-viral-load-measurement-in-venous-blood-and-fingerprick-blood-using-abbott-realtime-hiv-1-dbs-assay
#14
Ning Tang, Vihanga Pahalawatta, Andrea Frank, Zowie Bagley, Raquel Viana, John Lampinen, Gregor Leckie, Shihai Huang, Klara Abravaya, Carole L Wallis
BACKGROUND: HIV RNA suppression is a key indicator for monitoring success of antiretroviral therapy. From a logistical perspective, viral load (VL) testing using Dried Blood Spots (DBS) is a promising alternative to plasma based VL testing in resource-limited settings. OBJECTIVES: To evaluate the analytical and clinical performance of the Abbott RealTime HIV-1 assay using a fully automated one-spot DBS sample protocol. STUDY DESIGN: Limit of detection (LOD), linearity, lower limit of quantitation (LLQ), upper limit of quantitation (ULQ), and precision were determined using serial dilutions of HIV-1 Virology Quality Assurance stock (VQA Rush University), or HIV-1-containing armored RNA, made in venous blood...
May 13, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28531380/are-traditional-body-fat-equations-and-anthropometry-valid-to-estimate-body-fat-in-children-and-adolescents-living-with-hiv
#15
Luiz Rodrigo Augustemak de Lima, Priscila Custódio Martins, Carlos Alencar Souza Alves Junior, João Antônio Chula de Castro, Diego Augusto Santos Silva, Edio Luiz Petroski
The aim of this study was to assess the validity of traditional anthropometric equations and to develop predictive equations of total body and trunk fat for children and adolescents living with HIV based on anthropometric measurements. Forty-eight children and adolescents of both sexes (24 boys) aged 7-17 years, living in Santa Catarina, Brazil, participated in the study. Dual-energy X-ray absorptiometry was used as the reference method to evaluate total body and trunk fat. Height, body weight, circumferences and triceps, subscapular, abdominal and calf skinfolds were measured...
May 19, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28531337/correlation-of-immune-phenotype-with-idh-mutation-in-diffuse-glioma
#16
Anna Sophie Berghoff, Barbara Kiesel, Georg Widhalm, Dorothee Wilhelm, Orsolya Rajky, Sebastian Kurscheid, Philip Kresl, Adelheid Wöhrer, Christine Marosi, Monika E Hegi, Matthias Preusser
Background: Tumor infiltrating lymphocytes (TILs) and programmed death ligand 1 (PD-L1) are targets of immune checkpoint inhibitors. Methods: Forty-three World Health Organization (WHO) grade II/III gliomas (39 IDH-mutant [mut], 4 IDH-wildtype [wt]) and 14 IDH-mut glioblastomas (GBM) were analyzed for TIL (CD3+; PD1+) infiltration and PD-L1 expression. Results were compared with the data of a previously published series of 117 IDH-wt glioblastomas. PD-L1 gene expression levels were evaluated in 677 diffuse gliomas grades II-IV from The Cancer Genome Atlas (TCGA) database...
May 20, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28531331/diagnostic-challenges-in-meningioma
#17
Martha Nowosielski, Nobert Galldiks, Sarah Iglseder, Philipp Kickingereder, Andreas von Deimling, Martin Bendszus, Wolfgang Wick, Felix Sahm
Advances in molecular profiling and the application of advanced imaging techniques are currently refreshing diagnostic considerations in meningioma patients. Not only technical refinements but also sophisticated histopathological and molecular studies have the potential to overcome some of the challenges during meningioma management. Exact tumor delineation, assessment of tumor growth and pathophysiological parameters were recently addressed by "advanced" magnetic resonance imaging and positron emission tomography...
May 20, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28531330/structural-basis-for-substrate-binding-and-catalytic-mechanism-of-a-human-rna-m5c-methyltransferase-nsun6
#18
Ru-Juan Liu, Tao Long, Jing Li, Hao Li, En-Duo Wang
5-methylcytosine (m5C) modifications of RNA are ubiquitous in nature and play important roles in many biological processes such as protein translational regulation, RNA processing and stress response. Aberrant expressions of RNA:m5C methyltransferases are closely associated with various human diseases including cancers. However, no structural information for RNA-bound RNA:m5C methyltransferase was available until now, hindering elucidation of the catalytic mechanism behind RNA:m5C methylation. Here, we have solved the structures of NSun6, a human tRNA:m5C methyltransferase, in the apo form and in complex with a full-length tRNA substrate...
May 22, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28531315/the-interaction-between-cytosine-methylation-and-processes-of-dna-replication-and-repair-shape-the-mutational-landscape-of-cancer-genomes
#19
Rebecca C Poulos, Jake Olivier, Jason W H Wong
Methylated cytosines (5mCs) are frequently mutated in the genome. However, no studies have yet comprehensively analysed mutation-methylation associations across cancer types. Here we analyse 916 cancer genomes, together with tissue type-specific methylation and replication timing data. We describe a strong mutation-methylation association across colorectal cancer subtypes, most interestingly in samples with microsatellite instability (MSI) or Polymerase epsilon (POLE) exonuclease domain mutations. By analysing genomic regions with differential mismatch repair (MMR) efficiency, we suggest a possible role for MMR in the correction of 5mC deamination events, potentially accounting for the high rate of 5mC mutation accumulation in MSI tumours...
May 22, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28531309/effect-of-antiretroviral-therapy-on-bone-and-renal-health-in-young-adults-infected-with-hiv-in-early-life
#20
Aylin B Unsal, Aviva S Mattingly, Sara E Jones, Julia B Purdy, James C Reynolds, Jeffrey B Kopp, Rohan Hazra, Colleen M Hadigan
Context: HIV antiretroviral (ARV) therapy is associated with renal and bone toxicity, but little is known about the potential cumulative effects in adults exposed to ARVs from birth. Objective: To prospectively evaluate renal and bone health in young adults with lifelong HIV and extensive ARV exposure. Design: Cross-sectional comparison of bone mineral density (BMD by dual-energy X-ray absorptiometry), bone turnover and renal function in young adults infected with HIV in early life (n=65) to matched healthy controls (n=23) and longitudinal evaluation (mean follow-up 4...
May 22, 2017: Journal of Clinical Endocrinology and Metabolism
keyword
keyword
67392
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"