Ruairi C Robertson, Thaddeus J Edens, Lynnea Carr, Kuda Mutasa, Ethan K Gough, Ceri Evans, Hyun Min Geum, Iman Baharmand, Sandeep K Gill, Robert Ntozini, Laura E Smith, Bernard Chasekwa, Florence D Majo, Naume V Tavengwa, Batsirai Mutasa, Freddy Francis, Joice Tome, Rebecca J Stoltzfus, Jean H Humphrey, Andrew J Prendergast, Amee R Manges
Stunting affects one-in-five children globally and is associated with greater infectious morbidity, mortality and neurodevelopmental deficits. Recent evidence suggests that the early-life gut microbiome affects child growth through immune, metabolic and endocrine pathways. Using whole metagenomic sequencing, we map the assembly of the gut microbiome in 335 children from rural Zimbabwe from 1-18 months of age who were enrolled in the Sanitation, Hygiene, Infant Nutrition Efficacy Trial (SHINE; NCT01824940), a randomized trial of improved water, sanitation and hygiene (WASH) and infant and young child feeding (IYCF)...
February 14, 2023: Nature Communications