Keren Middelkoop, Lisa K Micklesfield, Neil Walker, Justine Stewart, Carmen Delport, David A Jolliffe, Amy E Mendham, Anna K Coussens, Averalda van Graan, James Nuttall, Jonathan C Y Tang, William D Fraser, Cyrus Cooper, Nicholas C Harvey, Richard L Hooper, Robert J Wilkinson, Linda-Gail Bekker, Adrian R Martineau
Randomised controlled trials (RCT) to determine the influence of vitamin D on bone mineral content (BMC) and fracture risk in children of Black African ancestry are lacking. We conducted a sub-study (n=450) nested within a Phase 3 RCT of weekly oral supplementation with 10,000 IU vitamin D3 vs. placebo for 3 years in HIV-uninfected Cape Town schoolchildren aged 6-11 years. Outcomes were BMC at the whole body less head (WBLH) and lumbar spine (LS) and serum 25-hydroxyvitamin D3 (25[OH]D3), parathyroid hormone (PTH), alkaline phosphatase, C-terminal telopeptide and procollagen type 1 N propeptide...
January 10, 2024: Journal of Bone and Mineral Research