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Vitamin D & HIv

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https://www.readbyqxmd.com/read/29739378/higher-serum-25-hydroxyvitamin-d-concentrations-are-associated-with-active-pulmonary-tuberculosis-in-hospitalised-hiv-infected-patients-in-a-low-income-tropical-setting-a-cross-sectional-study
#1
Cuthbert Musarurwa, Lynn Sodai Zijenah, Doreen Zvipo Mhandire, Tsitsi Bandason, Kudakwashe Mhandire, Maria Mary Chipiti, Marshall Wesley Munjoma, Witmore Bayayi Mujaji
BACKGROUND: The inherent risk of developing tuberculosis (TB) in HIV- infected individuals is further enhanced by hypovitaminosis D. Interventions that offset HIV-associated immune deterioration potentially arrest disease progression and incidence of opportunistic infections including TB. Despite conflicting reports on association between vitamin D deficiency (VDD) and risk of TB, vitamin D (VD) supplementation remains a promising intervention. METHODS: We conducted a comparative cross-sectional study on 145 HIV+ /pulmonary TB+ (PTB) and 139 HIV+ /PTB- hospitalised patients to investigate association of vitamin D status and risk of PTB...
May 8, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29713871/continued-interest-and-controversy-vitamin-d-in-hiv
#2
REVIEW
Evelyn Hsieh, Michael T Yin
PURPOSE OF REVIEW: Vitamin D (VitD) deficiency is highly prevalent among HIV-infected individuals. Given the overlapping risk for several chronic disease and immunomodulatory outcomes from both long-standing HIV and VitD deficiency, there is great interest in clarifying the clinical role of VitD for this population. RECENT FINDINGS: Recent studies have expanded our knowledge regarding the epidemiology and mechanisms of VitD deficiency-associated outcomes in the setting of HIV...
April 30, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29709013/prevalence-of-and-risk-factors-for-low-bone-mineral-density-in-spanish-treated-hiv-infected-patients
#3
Miguel Cervero, Rafael Torres, Jose Luís Agud, Victoria Alcázar, Juan José Jusdado, Concepción García-Lacalle, Santiago Moreno
OBJECTIVES: Several studies have involved antiretroviral therapy in the pathogenesis of low bone mineral density (BMD), while others have not confirmed this association. In this study we analyze the impact of HIV status, traditional risk factors and antiretroviral therapy in BMD in an HIV-infected population living in Madrid. MATERIAL AND METHODS: We performed a cross-sectional analysis of 107 individuals infected with HIV and exposed to antiretroviral treatment to estimate the prevalence of decreased BMD...
2018: PloS One
https://www.readbyqxmd.com/read/29661598/vitamin-d-supplementation-bone-turnover-and-inflammation-in-hiv-infected-patients
#4
L Benguella, A Arbault, A Fillion, M Blot, C Piroth, D Denimal, L Duvillard, P Ornetti, P Chavanet, J-F Maillefert, L Piroth
OBJECTIVE: To assess whether vitamin D supplementation could be associated with a modification of inflammatory markers and bone turnover in HIV-1-infected patients. PATIENTS AND METHODS: Patients who participated in an initial survey in 2010 and who were followed in the same department were included in a new study in 2012. Between 2010 and 2012, vitamin D supplementation was offered to patients presenting with hypovitaminosis D as per appropriate guidelines. Clinical examinations were performed, and fasting blood samples were taken for inflammation and bone marker evaluations...
April 13, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29593721/vitamin-d-in-human-immunodeficiency-virus-infection-influence-on-immunity-and-disease
#5
REVIEW
María Ángeles Jiménez-Sousa, Isidoro Martínez, Luz María Medrano, Amanda Fernández-Rodríguez, Salvador Resino
People living with human immunodeficiency virus (HIV) infection typically have hypovitaminosis D, which is linked to a large number of pathologies, including immune disorders and infectious diseases. Vitamin D (VitD) is a key regulator of host defense against infections by activating genes and pathways that enhance innate and adaptive immunity. VitD mediates its biological effects by binding to the Vitamin D receptor (VDR), and activating and regulating multiple cellular pathways. Single nucleotide polymorphisms in genes from those pathways have been associated with protection from HIV-1 infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29582037/blood-screen-findings-in-a-2-year-cohort-of-newly-arrived-refugees-to-sydney-australia
#6
Choisung C Ngo, Christine Maidment, Lisa Atkins, Sandy Eagar, Mitchell M Smith
OBJECTIVES: To describe the prevalence of certain health conditions in newly arrived refugees to Sydney, Australia, and thereby help inform screening practices. STUDY TYPE: A clinical audit of routinely collected pathology results. METHODS: Demographics and pathology results from a nurse-led health assessment program for newly arrived refugees during 2013 and 2014 were analysed. Prevalences of screened conditions were calculated, and compared by country of birth and other demographic features...
March 15, 2018: Public Health Research & Practice
https://www.readbyqxmd.com/read/29568546/effect-of-calcium-and-vitamin-d-supplementation-on-bone-mineral-accrual-among-hiv-infected-thai-adolescents-with-low-bone-mineral-density
#7
EDITORIAL
Thanyawee Puthanakit, Orasri Wittawatmongkol, Voraporn Poomlek, Tavitiya Sudjaritruk, Chantaphat Brukesawan, Torsak Bunupuradah, Sirintip Sricharoenchai, Thongsuai Chuanjaroen, Wasana Prasitsuebsai, Kulkanya Chokephaibulkit
Background:  The benefits of calcium and vitamin D supplementation for low bone mass remains controversial. This study assessed the changes in bone mineral density (BMD) during periods without and with calcium and vitamin D supplementation among HIV-infected adolescents with low BMD. Method:  Perinatally HIV-infected Thai adolescents aged 12-20 years were enrolled into Phase 1 (pre-supplementation) to evaluate longitudinal change of BMD. We provided education about appropriate dietary intake and exercise...
January 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29550079/vitamin-d-deficiency-and-periodontal-clinical-attachment-loss-in-hiv-seropositive-women-a-secondary-analysis-conducted-in-the-women-s-interagency-hiv-study-wihs
#8
Panagiotis Dragonas, Linda M Kaste, Martha Nunn, Praveen K Gajendrareddy, Kathleen M Weber, Mardge Cohen, Oluwatoyin M Adeyemi, Audrey L French, Herve Y Sroussi
OBJECTIVE: The aim of this study was to test a hypothesized positive association between low vitamin D (VitD) serum levels and the severity of periodontal disease in women with HIV infection. STUDY DESIGN: This was a cross-sectional secondary analysis of data from an oral substudy conducted within the Chicago site of the Women's Interagency HIV Study. Serum VitD levels and clinical attachment loss (CAL) measurements were available for 74 women with HIV infection...
February 19, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29547433/vitamin-d-status-and-immune-function-reconstitution-in-hiv-infected-men-initiating-therapy
#9
Alison G Abraham, Long Zhang, Keri Calkins, Adrienne Tin, Andrew Hoofnagle, Frank J Palella, Michelle M Estrella, Lisa P Jacobson, Mallory D Witt, Lawrence A Kingsley, Todd T Brown
OBJECTIVE: Despite effective antiretroviral therapy (HAART) and durable viral suppression, many HIV-infected individuals still do not achieve CD4 cell count (CD4) normalization. Vitamin D has immunoregulatory functions, including inducing the development of T cells and higher levels may improve CD4 rebound. DESIGN: Longitudinal study of men from the Multicenter AIDS Cohort Study who virally suppressed following HAART initiation and had pre-HAART and post-HAART 25(OH)D and 1,25(OH)2D measurements and repeated measures of CD4...
May 15, 2018: AIDS
https://www.readbyqxmd.com/read/29493287/vitamin-d-serum-levels-and-receptor-genetic-polymorphisms-are-associated-with-hepatitis-b-virus-and-hiv-infections-and-ifn-%C3%AE-levels
#10
Wenfeng Gao, Rui Wang, Xiaojun Wang, Hao Wu, Yang Wang, Xiaofan Lu, Li Li, Jiasheng Zheng, Wei Li
AIM: Vitamin D is involved in antiviral/antitumor activities. Its associations to hepatitis B virus (HBV), HIV and hepatocellular carcinoma (HCC) are unclear. MATERIALS & METHODS: A retrospective study was conducted on 232 chronic hepatitis B (CHB) patients and 72 HIV-infected patients. The correlation between serum 25(OH)D3 and 25 vitamin D receptor single nucleotide polymorphisms to disease progression and interferons were evaluated. RESULTS: The 25(OH)D3 was associated with HBV infection and progression...
September 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29432231/noncommunicable-diseases-in-adolescents-with-perinatally-acquired-hiv-1-infection-in-high-income-and-low-income-settings
#11
Steve Innes, Kunjal Patel
PURPOSE OF REVIEW: Perinatally HIV-infected adolescents may be at increased risk of noninfectious comorbidities later in life. This review summarizes recent advances in the understanding of noncommunicable diseases (NCD) among HIV-infected adolescents in high-income and lower middle-income countries, and identifies key questions that remain unanswered. We review atherosclerotic vascular disease (AVD), chronic bone disease (CBD), chronic kidney disease (CKD), and chronic lung disease (CLD)...
May 2018: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29378042/vitamin-e-status-is-inversely-associated-with-risk-of-incident-tuberculosis-disease-among-household-contacts
#12
Omowunmi Aibana, Molly F Franke, Chuan-Chin Huang, Jerome T Galea, Roger Calderon, Zibiao Zhang, Mercedes C Becerra, Emily R Smith, Carmen Contreras, Rosa Yataco, Leonid Lecca, Megan B Murray
Background: Few studies have previously assessed how pre-existing vitamin E status is associated with risk of tuberculosis (TB) disease progression. Objective: We evaluated the association between baseline plasma concentrations of 3 vitamin E isomers (α-tocopherol, γ-tocopherol, and δ-tocopherol) and TB disease risk. Methods: We conducted a case-control study nested within a longitudinal cohort of household contacts (HHCs) of pulmonary TB cases in Lima, Peru...
January 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29361637/secondary-hyperparathyroidism-in-hiv-infected-patients-in-central-europe
#13
Sebastian Noe, Celia Oldenbuettel, Silke Heldwein, Carmen Wiese, Ariane von Krosigk, Rita Pascucci, Katharina Ruecker, Hans Jaeger, Eva Wolf
Secondary hyperparathyroidism (sHPT) might be a contributor to increased risk of osteoporosis in adult HIV patients but there is little data available on this issue in this particular population. The aim of the study was to investigate the prevalence of sHPT in an HIV-infected population with normal kidney function and to evaluate its risk factors in HIV patients. This cross-sectional study was carried out in a single HIV center in Germany using routine data from patients with normal kidney function attending the clinic between January 1st and December 31st, 2016...
April 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29301284/vitamin-d-status-and-the-relationship-with-bone-fragility-fractures-in-hiv-infected-patients-a-case-control-study
#14
Marco Atteritano, Luigi Mirarchi, Emmanuele Venanzi-Rullo, Domenico Santoro, Chiara Iaria, Antonino Catalano, Antonino Lasco, Vincenzo Arcoraci, Alberto Lo Gullo, Alessandra Bitto, Francesco Squadrito, Antonio Cascio
HIV-infected patients show high risk of fracture. The aims of our study were to determine the prevalence of vertebral fractures (VFs) and their associations with vitamin D in HIV patients. 100 patients with HIV infection and 100 healthy age- and sex-matched controls were studied. Bone mineral density was measured by quantitative ultrasound at the non-dominant heel. Serum osteocalcin and C-terminal telopeptide of collagen type 1 served as bone turnover markers. Bone ultrasound measurements were significantly lower in patients compared with controls (Stiffness Index (SI): 80...
January 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29181264/evaluation-of-bone-mineral-density-and-related-parameters-in-patients-with-haemophilia-a-single-center-cross-sectional-study
#15
Hatice Demet Kiper Unal, Melda Comert Ozkan, Fatos Dilan Atilla, Zuhal Demirci, Nur Soyer, Ilgin Yildirim Simsir, Ozgur Omur, Kazim Capaci, Guray Saydam, Fahri Sahin
Haemophilia has been associated with low bone mineral density (BMD) probably due to some predisposing factors. The aim of this study was to evaluate the relationship between BMD and potential clinical predictors in adult haemophilic patients. Fortynine patients with moderate and severe haemophilia were enrolled. BMD was measured by Dual Energy X-Ray Absorptiometry (DXA) and blood tests were performed for vitamin D, calcium, phosphore, alkaline phosphatase and parathormone levels. Functional Independence Score in Haemophilia (FISH) and Haemophilia Joint Health Score (HJHS) were used to assess musculoskeletal functions...
2017: American Journal of Blood Research
https://www.readbyqxmd.com/read/29140875/bone-mineral-density-declines-twice-as-quickly-among-hiv-infected-women-compared-with-men
#16
Kristine M Erlandson, Jordan E Lake, Myung Sim, Julian Falutz, Carla M Prado, Ana Rita Domingues da Silva, Todd T Brown, Giovanni Guaraldi
BACKGROUND: Initial declines in bone mineral density (BMD) after antiretroviral therapy initiation in HIV are well described, but data on long-term changes and risk factors for decline, particularly among women, are limited. METHODS: HIV-infected men and women in the Modena Metabolic Clinic underwent dual-energy X-ray absorptiometry (DXA) scans every 6-12 months for up to 10 years (median 4.6 years). Mixed effect regression models in combined and sex-stratified models determined annual rates of decline and clinical factors associated with BMD...
March 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29136775/high-parathyroid-hormone-concentration-in-tenofovir-treated-patients-are-due-to-inhibition-of-calcium-sensing-receptor-activity
#17
Alessandra Mingione, Katia Maruca, Federica Chiappori, Francesca Pivari, Caterina Brasacchio, Tiziana Quirino, Ivan Merelli, Laura Soldati, Paolo Bonfanti, Stefano Mora
Bone health impairment is a common finding in HIV-infected patients on antiretroviral treatment. High serum parathyroid hormone (PTH) concentration in patients on antiretroviral treatment containing tenofovir disoproxil fumarate (TDF) has been reported. Hyperparathyroidism was not always sustained by a reduction in vitamin D concentration. We thus hypothesized a direct inhibitory effect of TDF on the Calcium-sensing receptor (CaSR), leading to hyperparathyroidism. Human embryonic kidney cells were transfected with CASR wild-type gene or mutated in different sites (N124K, T1051G, C788T, T888M)...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29110385/vitamin-d-and-progression-of-carotid-intima-media-thickness-in-hiv-positive-canadians
#18
H Huff, A T Merchant, E Lonn, E Pullenayegum, F Smaill, M Smieja
OBJECTIVES: Based on a growing body of evidence implicating low vitamin D status in the development of cardiovascular disease (CVD), we hypothesized that in Canadian HIV-positive adults, low 25-hydroxyvitamin D (25(OH)D) concentration would be associated with increased subclinical vascular disease progression. METHODS: We prospectively studied the relationship between baseline 25(OH)D and subsequent progression of carotid intima-media thickness (CIMT) between 2002 and 2011, in the Canadian HIV Vascular Study using stored blood specimens...
February 2018: HIV Medicine
https://www.readbyqxmd.com/read/29094039/host-directed-therapeutic-strategies-for-tuberculosis
#19
REVIEW
Afsal Kolloli, Selvakumar Subbian
Tuberculosis (TB), caused by Mycobacterium tuberculosis ( Mtb ), remains a leading cause of morbidity and mortality in humans worldwide. Currently, the standard treatment for TB involves multiple antibiotics administered for at least 6 months. Although multiple antibiotics therapy is necessary to prevent the development of drug resistance, the prolonged duration of treatment, combined with toxicity of drugs, contributes to patient non-compliance that can leads to the development of drug-resistant Mtb (MDR and XDR) strains...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29071047/patterns-of-vitamin-d-parathyroid-hormone-and-c-terminal-telopeptide-of-collagen-type-1-in-caucasian-and-african-descent-hiv-infected-populations-in-central-europe
#20
Sebastian Noe, Celia Oldenbuettel, Silke Heldwein, Hans Jaeger, Eva Wolf
Risk factors for bone loss in HIV patients might differ or have a different impact in African descent compared to Caucasian populations. The aim of the paper is to analyze the relevance of risk factors on surrogate markers of bone metabolism in HIV-infected African descent and Caucasian patients. This is a cross-sectional study in a single HIV-specialized research and clinical care center in Munich, Germany. We included 889 patients in the study, among them 771 Caucasians (86.7%). Only in Caucasians lower vitamin D levels [OR: 2...
October 2, 2017: Infectious Disease Reports
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