keyword
MENU ▼
Read by QxMD icon Read
search

hypertension salt

keyword
https://www.readbyqxmd.com/read/28922660/mitochondrial-dysfunction-and-altered-renal-metabolism-in-dahl-salt-sensitive-rats
#1
Zhengjun Wang, Qiong Sun, Na Sun, Mingyu Liang, Zhongmin Tian
BACKGROUND/AIMS: The kidney plays a critical role in the control of blood pressure and its elevation in salt-induced hypertension. Mitochondrial dysfunction, especially in energy metabolism, has been associated with hypertension. Here, we aimed to investigate mitochondrial function and metabolic features in renal mitochondria of Dahl salt-sensitive (SS) rats to gain further insight into the relationship between mitochondrial metabolism and predisposition to hypertension. METHODS: In this study, SS rats fed low-salt (LS) or high-salt (HS) diets were used to investigate mitochondrial function and metabolism including mitochondrial enzyme activities, pyridine nucleotides, metabolites, and oxidative stress by biochemical analysis and gas chromatography-mass spectrometer (GC-MS)...
September 19, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28911936/exercise-training-in-patients-with-pulmonary-and-systemic-hypertension-a-unique-therapy-for-two-different-diseases
#2
REVIEW
Massimo Leggio, Augusto Fusco, Giorgio Limongelli, Luca Sgorbini
Pulmonary hypertension is a potentially life-threatening condition. Given its evolving definition, the incidence and prevalence of the disease is difficult to define, but registries suggest an increased global awareness. The management of patients with pulmonary arterial hypertension is highly specialised and requires multi-disciplinary input from a range of healthcare professionals, including cardiologists, respiratory physicians, rheumatologists, rehabilitation physicians and cardio-pulmonary physiotherapists...
September 11, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28911177/deoxycorticosterone-salt-mediated-cardiac-inflammation-and-fibrosis-are-dependent-on-functional-clock-signaling-in-male-mice
#3
Elizabeth K Fletcher, James Morgan, David R Kennaway, Laura A Bienvenu, Amanda J Rickard, Lea M D Delbridge, Peter J Fuller, Colin D Clyne, Morag J Young
Activation of the mineralocorticoid receptor (MR) promotes inflammation, fibrosis, and hypertension. Clinical and experimental studies show that MR antagonists have significant therapeutic benefit for all-cause heart failure; however, blockade of renal MRs limits their widespread use. Identification of key downstream signaling mechanisms for the MR in the cardiovascular system may enable development of targeted MR antagonists with selectivity for pathological MR signaling and lower impact on physiological renal electrolyte handling...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28904149/correction-to-intracerebroventricular-infusion-of-the-pro-renin-receptor-antagonist-pro20-attenuates-deoxycorticosterone-acetate-salt-induced-hypertension
#4
(no author information available yet)
No abstract text is available yet for this article.
October 2017: Hypertension
https://www.readbyqxmd.com/read/28902380/-organ-interactions-heart-and-kidney
#5
Daniel Salleck, Stefan John
The interactions between heart and kidney are various and of clinical relevance. Worsening of one organ often influences the function of the other. With NYHA and KDIGO we have classification systems for heart and kidney failure and those should be used for cardiorenal systems as well. Furthermore there is a useful classification system for cardiorenal syndromes itself. Cardiorenal syndrome is a complex illness which should be treated by interdisciplinary medical teams. A key roll in pathophysiology is the renin-angiotensin-aldosteron-system (RAAS)...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28901845/a-review-of-patents-on-therapeutic-potential-and-delivery-of-hydrogen-sulfide
#6
Richa Verma, Yumna Akhtar, Somnath Singh
Hydrogen sulfide (H2S) is a colorless gas with a characteristic smell of rotten eggs. Once only thought of as a toxic gas, evidence now shows that H2S plays major roles in pathological and physiological activities. These roles are being utilized to treat diseases and disorders ranging from hypertension, inflammation, edema, cardiovascular issues, chronic pain, cancer, and many more. Challenges facing the use of H2S currently involve achieving the optimum therapeutic concentrations, synthesizing chemically and physiologically stable donors, and developing clinically appropriate delivery systems...
September 11, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28899928/treatment-of-hypertension-by-increasing-impaired-endothelial-trpv4-kca2-3-interaction
#7
Dongxu He, Qiongxi Pan, Zhen Chen, Chunyuan Sun, Peng Zhang, Aiqin Mao, Yaodan Zhu, Hongjuan Li, Chunxiao Lu, Mingxu Xie, Yin Zhou, Daoming Shen, Chunlei Tang, Zhenyu Yang, Jian Jin, Xiaoqiang Yao, Bernd Nilius, Xin Ma
The currently available antihypertensive agents have undesirable adverse effects due to systemically altering target activity including receptors, channels, and enzymes. These effects, such as loss of potassium ions induced by diuretics, bronchospasm by beta-blockers, constipation by Ca(2+) channel blockers, and dry cough by ACEI, lead to non-compliance with therapies (Moser, 1990). Here, based on new hypertension mechanisms, we explored a new antihypertensive approach. We report that transient receptor potential vanilloid 4 (TRPV4) interacts with Ca(2+)-activated potassium channel 3 (KCa2...
September 12, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28889932/small-vessel-disease-and-dietary-salt-intake-cross-sectional-study-and-systematic-review
#8
Stephen D J Makin, Ghaida F Mubki, Fergus N Doubal, Kirsten Shuler, Julie Staals, Martin S Dennis, Joanna M Wardlaw
BACKGROUND: Higher dietary salt intake increases the risk of stroke and may increase white matter hyperintensity (WMH) volume. We hypothesized that a long-term higher salt intake may be associated with other features of small vessel disease (SVD). METHODS: We recruited consecutive patients with mild stroke presenting to the Lothian regional stroke service. We performed brain magnetic resonance imaging, obtained a basic dietary salt history, and measured the urinary sodium/creatinine ratio...
September 7, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28888840/teneligliptin-prevents-cardiomyocyte-hypertrophy-fibrosis-and-development-of-hypertensive-heart-failure-in-dahl-salt-sensitive-rats
#9
Masayoshi Yamamoto, Tomoko Ishizu, Yoshihiro Seo, Yoshimi Suto, Seika Sai, Dongzhu Xu, Nobuyuki Murakoshi, Taizo Kimura, Yasushi Kawakami, Kazutaka Aonuma
BACKGROUND: We investigated the effects of the DPP4 inhibitor, teneligliptin, on cardiac function and hemodynamics during heart failure in hypertensive model rats. METHODS AND RESULTS: Fifty-five male Dahl salt-sensitive rats were divided into four groups: control group (0.3% NaCl chow, n=13), hypertension (HT) group (8% NaCl chow, n=20), HT-early TNL group (8% NaCl chow and teneligliptin from 6 weeks, n=10), and HT-late TNL group (8% NaCl chow and teneligliptin from 10 weeks, n=12)...
September 6, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28887369/genetic-mechanisms-of-human-hypertension-and-their-implications-for-blood-pressure-physiology
#10
Eric Seidel, Ute I Scholl
Hypertension, or elevated blood pressure, constitutes a major public health burden that affects more than 1 billion people worldwide and contributes to about 9 million deaths annually. Hereditary factors are thought to contribute to up to 50% of interindividual blood pressure variability. Blood pressure in the general population approximately shows a normal distribution and is thought to be a polygenic trait. In rare cases, early-onset hypertension or hypotension are inherited as Mendelian traits. The identification of the underlying Mendelian genes and variants has contributed to our understanding of the physiology of blood pressure regulation, emphasizing renal salt handling and the renin angiotensin aldosterone system as players in the determination of blood pressure...
September 8, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28886258/a-questionnaire-survey-of-general-practitioners-in-japan-s-kanagawa-prefecture-for-the-japanese-society-of-hypertension-guidelines-for-the-management-of-hypertension-2014
#11
Kazuo Kobayashi, Kazuyoshi Sato, Nobuo Hatori, Masaaki Miyakawa
To evaluate the Japanese Society of Hypertension Guidelines for the Management of Hypertension 2014 (JSH2014) among Japanese general practitioners (GPs), we used a questionnaire survey with 209 GPs from the Kanagawa Physicians Society. Overall, 93.6% of GPs felt that the contents of the JSH2014 were useful. Based on the results showing that 81.8% of GPs instructed the measurement of blood pressure (BP) in the early morning at home to most patients, GP's acceptance of home BP methods and their penetration among patients with hypertension were considerably high...
September 8, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28876684/differences-in-microbiome-in-rat-models-of-cardiovascular-disease
#12
A Thiba, C A Umar, S Myende, E Nweke, K Rumbold, G Candy
BACKGROUND: Recent studies have underscored the important role the gut metagenome in various human diseases, including diabetes and obesity. Hypertension is a major risk factor for cardiovascular disease, stroke, and heart and kidney failure, and affects approximately 25% of the world's adult population. The cause of essential hypertension remains unknown. Patients given antibiotics show blood pressure changes and transfer of gut bacteria from hypertensive to normal WKY rats resulted in the latter developing hypertension...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28874461/selective-deletion-of-renin-b-in-the-brain-alters-drinking-and-metabolism
#13
Keisuke Shinohara, Pablo Nakagawa, Javier Gomez, Donald A Morgan, Nicole K Littlejohn, Matthew D Folchert, Benjamin J Weidemann, Xuebo Liu, Susan A Walsh, Laura L Ponto, Kamal Rahmouni, Justin L Grobe, Curt D Sigmund
The brain-specific isoform of renin (Ren-b) has been proposed as a negative regulator of the brain renin-angiotensin system (RAS). We analyzed mice with a selective deletion of Ren-b which preserved expression of the classical renin (Ren-a) isoform. We reported that Ren-b(Null) mice exhibited central RAS activation and hypertension through increased expression of Ren-a, but the dipsogenic and metabolic effects in Ren-b(Null) mice are unknown. Fluid intake was similar in control and Ren-b(Null) mice at baseline and both exhibited an equivalent dipsogenic response to deoxycorticosterone acetate-salt...
September 5, 2017: Hypertension
https://www.readbyqxmd.com/read/28869490/the-impact-of-hemodialysis-frequency-and-duration-on-blood-pressure-management-and-quality-of-life-in-end-stage-renal-disease-patients
#14
REVIEW
Mohammad Ali Shafiee, Pouyan Chamanian, Pouyan Shaker, Yasmin Shahideh, Behrooz Broumand
Cardiovascular complications are the most prominent causes of morbidity and mortality among chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients undergoing standard hemodialysis (HD) therapy. Cardiovascular disease risk is increased significantly through persistent hypertension and blood pressure (BP) fluctuation, which are the most common complications of CKD. It was hypothesized that an extended approach with lengthier and more frequent dialysis sessions, referred to in this paper as "extended hemodialysis" (EHD), can potentially lower and stabilize blood pressure, and consequently reduce the rate of morbidity and mortality...
September 2, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28867730/up-regulation-of-the-voltage-gated-kv2-1-k-channel-in-the-renal-arterial-myocytes-of-dahl-salt-sensitive-hypertensive-rats
#15
Kazunobu Ogiwara, Susumu Ohya, Yoshiaki Suzuki, Hisao Yamamura, Yuji Imaizumi
Salt-sensitive hypertension induces renal injury via decreased blood flow in the renal artery (RA), and ion channel dysfunction in RA myocytes (RAMs) may be involved in the higher renal vascular resistance. We examined the effects of several voltage-gated K(+) (KV) channel blockers on the resting tension in endothelium-denuded RA strips and delayed-rectifier K(+) currents in RAMs of Dahl salt-sensitive hypertensive rats (Dahl-S) fed with low- (Dahl-LS) and high-salt diets (Dahl-HS). The tetraethylammonium (TEA)-induced contraction in RA strips were significantly larger in Dahl-HS than Dahl-LS...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28863887/development-of-monoclonal-antibodies-against-the-human-3%C3%AE-hydroxysteroid-dehydrogenase-isomerase-isozymes
#16
Celso E Gomez-Sanchez, Mark Lewis, Kazutaka Nanba, William E Rainey, Maniselvan Kuppusamy, Elise P Gomez-Sanchez
The human 3 β -hydroxysteroid dehydrogenase/isomerase (HSD3B) enzymes catalyze the conversion of 3 β -hydroxy 5-6 steroids into 3-keto 4-5 steroids, which is required for the synthesis of the mature steroid hormones secreted by the adrenal and gonads. The human has 2 isozymes, the HSD3B1 that is traditionally located in placenta and extra-adrenal tissues and the HSD3B2 that is expressed in the adrenal and gonads. Mice with both cryptochrome 1 and 2 genes deletion were recently found to have salt-sensitive hypertension and hyperaldosteronism...
August 29, 2017: Steroids
https://www.readbyqxmd.com/read/28862701/deletion-of-nedd4-2-results-in-progressive-kidney-disease-in-mice
#17
Tanya L Henshall, Jantina A Manning, Omri S Alfassy, Pranay Goel, Natasha A Boase, Hiroshi Kawabe, Sharad Kumar
NEDD4-2 (NEDD4L), a ubiquitin protein ligase of the Nedd4 family, is a key regulator of cell surface expression and activity of the amiloride-sensitive epithelial Na(+) channel (ENaC). While hypomorphic alleles of Nedd4-2 in mice show salt-sensitive hypertension, complete knockout results in pulmonary distress and perinatal lethality due to increased cell surface levels of ENaC. We now show that Nedd4-2 deficiency in mice also results in an unexpected progressive kidney injury phenotype associated with elevated ENaC and Na(+)Cl(-) cotransporter expression, increased Na(+) reabsorption, hypertension and markedly reduced levels of aldosterone...
September 1, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28862406/double-blind-randomized-controlled-clinical-trial-of-nacl-chitosan-3-vs-nacl-on-high-blood-pressure-parameters-of-healthy-volunteers-with-pre-hypertension-characterized-by-a-systolic-blood-pressure-between-130-mmhg-and-140-mmhg
#18
François-André Allaert
BACKGROUND: Because of the impressive increase in the risk of cardiovascular complications associated with levels of BP previously considered to be normal, the JNC 7 report has introduced a new classification that includes the term "prehypertension" for those with BPs ranging from 120-139 mmHg systolic and/or 80-89 mmHg diastolic. In the framework of a salt reduction as recommended by health authorities, this trial evaluates if the use of Symbiosal® reduces more prehypertension than standard table marine salt (NaCl)...
August 31, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28859929/cutaneous-and-renal-vasodilatory-response-to-local-pressure-application-a-comparative-study-in-mice
#19
Anne-Laure Begey, Kiao Ling Liu, Ming Lo, Audrey Josset-Lamaugarny, Nicolas Picard, Catherine Gauthier, Berengere Fromy, Dominique Sigaudo-Roussel, Laurence Dubourg
BACKGROUND AND AIM: We have reported a novel relationship involving mechanical stimulation and vasodilation in rodent and human skin, referred to as pressure-induced vasodilation (PIV). It is unknown whether this mechanism exists in kidney and reflects the microcirculation in deep organs. Therefore, we compared the skin and kidney PIV to determine whether their changes were similar. METHODS: In anesthetized mice fed a normal salt-diet, laser Doppler flux (LDF) signals were measured when an increase in local pressure was applied to the surface of the head skin with the rate of 2...
August 30, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28857085/enteric-dysbiosis-linked-gut-barrier-disruption-triggers-early-renal-injury-induced-by-chronic-high-salt-feeding-in-mice
#20
Jingjuan Hu, Haihua Luo, Jieyan Wang, Wenli Tang, Junqi Lu, Shan Wu, Zhi Xiong, Guizhi Yang, Zhenguo Chen, Tian Lan, Hongwei Zhou, Jing Nie, Yong Jiang, Peng Chen
Chronic high-salt diet-associated renal injury is a key risk factor for the development of hypertension. However, the mechanism by which salt triggers kidney damage is poorly understood. Our study investigated how high salt (HS) intake triggers early renal injury by considering the 'gut-kidney axis'. We fed mice 2% NaCl in drinking water continuously for 8 weeks to induce early renal injury. We found that the 'quantitative' and 'qualitative' levels of the intestinal microflora were significantly altered after chronic HS feeding, which indicated the occurrence of enteric dysbiosis...
August 25, 2017: Experimental & Molecular Medicine
keyword
keyword
67388
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"