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https://www.readbyqxmd.com/read/29782857/quaternary-ammonium-salt-of-u50-488h-elicits-protective-effects-against-hypoxic-pulmonary-hypertension
#1
Yaguang Zhou, Xin Tian, Xueying Wang, Yuanbo Wang, Rong Fan, Yuemin Wang, Na Feng, Shumiao Zhang, Haitao Guo, Xiaoming Gu, Min Jia, Wen Yin, Zuoxu Hou, Juan Li, Jianming Pei
The present study aimed to investigate the role of quaternary ammonium salt of U50,488H (Q-U50,488H) in hypoxic pulmonary hypertension (HPH) and underlying mechanisms involved. A HPH animal model was established in rats under hypoxia and the mean pulmonary arterial pressure (mPAP) and right ventricular pressure (RVP) were measured. Relaxation of the pulmonary artery in response to Q-U50,488H was determined. In addition, expression and activity of endothelial nitric oxide (NO) synthase (eNOS) and inducible NO synthase (iNOS) with NO content, Akt expression, total antioxidant capacity (T-AOC), and gp91phox were evaluated...
May 18, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29780639/factors-predicting-self-care-behaviors-among-low-health-literacy-hypertensive-patients-based-on-health-belief-model-in-bushehr-district-south-of-iran
#2
Azam Larki, Rahim Tahmasebi, Mahnoush Reisi
The aim of this study was to determine the factors influencing adherence to self-care behaviors among low health literacy hypertensive patients based on health belief model. A cross-sectional study was conducted among 152 hypertensive patients with low health literacy. Patients with limited health literacy were identified by S-TOFHLA. The data were collected using H-scale for assessing self-care behaviors and, HK-LS for assessing knowledge of hypertension. A researcher-made questionnaire was applied for collecting data of health belief model constructs...
2018: International Journal of Hypertension
https://www.readbyqxmd.com/read/29773847/association-between-urinary-sodium-excretion-and-uric-acid-and-its-interaction-on-the-risk-of-prehypertension-among-chinese-young-adults
#3
Yang Wang, Jia-Wen Hu, Peng-Fei Qu, Ke-Ke Wang, Yu Yan, Chao Chu, Wen-Ling Zheng, Xian-Jing Xu, Yong-Bo Lv, Qiong Ma, Ke Gao, Yue Yuan, Hao Li, Zu-Yi Yuan, Jian-Jun Mu
High uric acid (UA) level and high salt intake are reportedly associated with cardiovascular disease. This study investigated the association between UA and urinary sodium excretion, as well as its interaction on the risk of prehypertension. A total of 1869 participants without hypertension were recruited from a previously established cohort in Shaanxi Province, China. The participants were classified as normotensive or prehypertensive on the basis of their blood pressure. Increasing quartiles of sodium excretion were associated with high urinary UA/creatinine levels in prehypertensive participants...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29767672/blockade-of-tlr4-within-the-paraventricular-nucleus-attenuates-blood-pressure-by-regulating-ros-and-inflammatory-cytokines-in-prehypertensive-rats
#4
Mo-Lin Wang, Xiao-Jing Yu, Xiao-Guang Li, De-Zhi Pang, Qing Su, Roland Osei Saahene, Hong-Bao Li, Xu-Ying Mao, Kai-Li Liu, Li-Yan Fu, Ying Li, Guo-Qing Zhu, Yu-Ming Kang
Background: Toll like receptor 4 (TLR4) has been implicated in the progression of cardiovascular disease, including hypertension. However, the role of TLR4 in the development of prehypertension is uncertain. Methods: Prehypertensive rats were treated with 8% salt for 12 weeks to induce prehypertension. These rats were then given either TAK-242 selective TLR4 blocker, or vehicle by bilateral micro-injection to the paraventricular nucleus (PVN). Blood pressure and renal sympathetic nerve activity were recorded...
May 15, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29767556/hydronephrosis-is-associated-with-elevated-plasmin-in-urine-in-pediatric-patients-and-rats-and-changes-in-ncc-and-%C3%AE-enac-abundance-in-rat-kidney
#5
Rikke Zachar, Ammar Al-Mashhadi, Henrik Dimke, Per Svenningsen, Boye L Jensen, Mattias Carlström
Obstruction of urine flow at the level of the pelvo-ureteric junction (UPJO) and subsequent development of hydronephrosis is one of the most common congenital renal malformations. UPJO is associated with development of salt-sensitive hypertension, which is set by the obstructed kidney, and with a stimulated renin-angiotensin-aldosterone system (RAAS) in rodent models. This study aimed at investigating the hypothesis that i) in pediatric patients with UPJO the RAAS is activated prior to surgical relief of the obstruction; ii) in rats with UPJO the RAAS activation is reflected by increased abundance of renal aldosterone-stimulated Na+ transporters; and iii) the injured UPJO kidney allows aberrant filtration of plasminogen leading to proteolytic activation of the epithelial sodium channel gamma subunit (γ-ENaC)...
May 16, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29767465/salt-inflammation-il-17-and-hypertension
#6
REVIEW
Ulrich O Wenzel, Marlies Bode, Christian Kurts, Heimo Ehmke
Traditionally, arterial hypertension and subsequent end-organ damage have been attributed to hemodynamic factors, but increasing evidence indicates that inflammation also contributes to the deleterious consequences of this disease. The immune system has evolved to prevent invasion of foreign microorganisms and to promote tissue healing after injury. However, this beneficial activity comes at a cost of collateral damage when the immune system overreacts to internal injury, such as prehypertension. Over the last years important findings have revolutionized hypertension research...
May 16, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29766048/phasic-stimulation-of-midbrain-dopamine-neuron-activity-reduces-salt-consumption
#7
Eleanor C Sandhu, Anushka B P Fernando, Elaine E Irvine, Kyoko Tossell, Michelle Kokkinou, Justyna Glegola, Mark A Smith, Oliver D Howes, Dominic J Withers, Mark A Ungless
Salt intake is an essential dietary requirement, but excessive consumption is implicated in hypertension and associated conditions. Little is known about the neural circuit mechanisms that control motivation to consume salt, although the midbrain dopamine system, which plays a key role in other reward-related behaviors, has been implicated. We, therefore, examined the effects on salt consumption of either optogenetic excitation or chemogenetic inhibition of ventral tegmental area (VTA) dopamine neurons in male mice...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29763909/cardiac-ablation-of-socs3-aggravates-doca-salt-induced-hypertrophic-remodeling-by-activation-of-gp130-dependent-signaling-in-mice
#8
Shuang Liu, Li-Xin Liu, Yun-Long Zhang, Song Lai, Yun-Peng Xie, Nan-Nan Li, Hong-Xia Wang, Yun-Long Xia, Ying Liu, Hui-Hua Li
BACKGROUND/AIMS: Cardiac remodeling is a critical pathogenetic process leading to heart failure. Suppressor of cytokine signaling-3 (SOCS3) is demonstrated as a key negative regulator of the gp130 receptor to inhibit cardiac hypertrophy. However, the role of SOCS3 in deoxycorticosterone-acetate (DOCA)-salt-induced cardiac remodeling remains unclear. METHODS: Cardiac-specific SOCS3 knockout (SOCS3cKO) and wild-type (WT) C57BL/6J mice were subjected to uninephrectomy and DOCA-salt for 3 weeks...
May 10, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29760664/reduced-renal-mass-salt-sensitive-hypertension-is-resistant-to-renal-denervation
#9
Ionut Tudorancea, Thomas E Lohmeier, Barbara T Alexander, Dragos Pieptu, Dragomir N Serban, Radu Iliescu
Aim: Activation of the sympathetic nervous system is common in resistant hypertension (RHT) and also in chronic kidney disease (CKD), a prevalent condition among resistant hypertensives. However, renal nerve ablation lowers blood pressure (BP) only in some patients with RHT. The influence of loss of nephrons per se on the antihypertensive response to renal denervation (RDNx) is unclear and was the focus of this study. Methods: Systemic hemodynamics and sympathetically mediated low frequency oscillations of systolic BP were determined continuously from telemetrically acquired BP recordings in rats before and after surgical excision of ∼80% of renal mass and subsequent RDNx...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29756493/association-between-urinary-sodium-excretion-and-coronary-heart-disease-in-hospitalized-elderly-patients-in-china
#10
Chun-Lin Li, Hai-Jun Wang, Quan-Jin Si, Jin Zhou, Kai-Liang Li, Yu Ding
Objective This study was performed to evaluate the association between urinary sodium excretion and coronary heart disease (CHD) in hospitalized elderly patients in China. Methods The 24-h urinary excretion specimens of 541 patients were collected, and the serum creatinine concentration and urinary sodium/potassium ratio were measured. Associations were explored by multivariate logistic regression analysis. Results The mean 24-h urinary sodium excretion was 200.4 mmol, corresponding to 11.7 g of salt intake...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29755228/effect-of-1-week-yoga-based-residential-program-on-cardiovascular-variables-of-hypertensive-patients-a-comparative-study
#11
Kashinath G Metri, Balaram Pradhan, Amit Singh, H R Nagendra
Introduction: Hypertension (HTN) is an important public health concern and a leading cause of morbidity and mortality worldwide. Yoga is a form of mind-body medicine shown to be effective in controlling blood pressure (BP) and reduces cardiac risk factors in HTN. Integrated approach of Yoga therapy (IAYT) is a residential yoga-based lifestyle intervention proven to be beneficial in several health conditions. Aim: To study the efficacy of 1 week of residential IAYT intervention on cardiovascular parameters in hypertensive patients...
May 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/29747759/limonin-alleviates-macro-and-micro-vascular-complications-of-metabolic-syndrome-in-rats-a-comparative-study-with-azelnidipine
#12
Noura A Hassan, Hany M El Bassossy, Ahmed Fahmy, Mona F Mahmoud
BACKGROUND: Hypertension is a serious component of metabolic syndrome (MetS). HYPOTHESIS: This research investigates the potential protective effect of limonin against MetS-associated hypertension in comparison with azelnidipine, a common calcium channel blocker. STUDY DESIGN: MetS was induced in rats by 10% fructose in water and 3% salt in diet over a 16-week period. Limonin (50 mg/kg) and azelnidipine (5 mg/kg) were administered daily in the last four weeks METHODS: Non-invasive blood pressure (BP) was recorded in conscious animals...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29745362/does-dietary-nitrate-say-no-to-cardiovascular-ageing-current-evidence-and-implications-for-research
#13
Mario Siervo, Filippo Scialò, Oliver M Shannon, Blossom C M Stephan, Ammar W Ashor
CVD are characterised by a multi-factorial pathogenesis. Key pathogenetic steps in the development of CVD are the occurrence of endothelial dysfunction and formation of atherosclerotic lesions. Reduced nitric oxide (NO) bioavailability is a primary event in the initiation of the atherosclerotic cascade. NO is a free radical with multiple physiological functions including the regulation of vascular resistance, coagulation, immunity and oxidative metabolism. The synthesis of NO proceeds via two distinct pathways identified as enzymatic and non-enzymatic...
May 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29744365/high-salt-intake-ameliorates-hyperglycemia-and-insulin-resistance-in-wbn-kob-lepr-fa-fa-rats-a-new-model-of-type-2-diabetes-mellitus
#14
Yoshiichi Takagi, Taichi Sugimoto, Masaya Kobayashi, Mitsuyuki Shirai, Fumitoshi Asai
High-salt intake is a major risk factor for developing hypertension in type 2 diabetes mellitus, but its effects on glucose homeostasis are controversial. We previously found that high-salt intake induces severe hypertension in WBN/Kob diabetic fatty (WBKDF) rats. In the present study, we examined the effects of a high-salt intake on glucose homeostasis in WBKDF rats. Male WBKDF rats and age-matched Wistar rats at 6 weeks of age were each divided into two groups and fed either a normal-sodium (NS, 0.26%) diet or high-sodium (HS, 8%) diet for 7 weeks...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29743397/-transplantation-associated-thrombotic-microangiopathy-confirmed-by-renal-biopsy
#15
Satoshi Miyamoto, Shunsuke Kimura, Yosuke Hosoya, Daisuke Hasegawa, Hisashi Ishida, Atsuro Daida, Toshihiro Matsui, Yuri Yoshimoto, Shinsuke Hirabayashi, Takuya Fujimaru, Tadashi Kumamoto, Shin-Ichiro Mori, Koyu Suzuki, Atsushi Manabe
An eight-year-old girl with myelodysplastic syndrome (refractory cytopenia) received a bone marrow transplant (BMT) from an unrelated donor because of immunosuppressive therapy failure. Following administration of foscarnet for cytomegalovirus reactivation at day40 post-BMT, serum creatinine increased, and proteinuria, hematuria, and hypertension gradually exacerbated and became prolonged. However, neither schistocytosis nor other organ damage was evident. At six months post-BMT, renal biopsy revealed diffuse glomerular damage with glomerular lobulation, a double contour of the glomerular basement membrane, erythrocyte congestion and thrombi in the glomerular endocapillaries, and mesangiolysis, confirming the diagnosis of transplantation-associated thrombotic microangiopathy (TA-TMA)...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29722788/renal-protective-effects-of-n-acetyl-seryl-aspartyl-lysyl-proline-ac-sdkp-in-obese-rats-on-a-high-salt-diet
#16
Mani Maheshwari, Cesar A Romero, Sumit R Monu, Nitin Kumar, Tang-Dong Liao, Edward L Peterson, Oscar A Carretero
BACKGROUND: Obesity is a public health problem, associated with salt sensitive hypertension, kidney inflammation, and fibrosis. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a tetra peptide with anti-inflammatory and anti-fibrotic properties. However, its effect on preventing kidney damage in obesity is unknown. We hypothesized that Zucker obese (ZO) rats on a high-salt (HS) diet develop renal damage, inflammation, fibrosis, and this is prevented with Ac-SDKP treatment. METHODS: Zucker lean (ZL) and ZO rats (8 weeks old) were treated with Ac-SDKP (1...
May 2, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29720880/blood-pressure-control-status-and-associated-factors-among-adult-hypertensive-patients-on-outpatient-follow-up-at-university-of-gondar-referral-hospital-northwest-ethiopia-a-retrospective-follow-up-study
#17
Yaregal Animut, Alemu Takele Assefa, Dereseh Gezie Lemma
Background: Large segments of the hypertensive population in the world are either untreated or inadequately treated. The incidence of heart failure and mortality from cardiovascular complications of hypertension is high among patients with uncontrolled blood pressure (BP). But BP control status of hypertensive patients has not been investigated in the study area. The study aimed to assess BP control status and determinant factors among adult hypertensive patients on antihypertensive medication attending outpatient follow-up at University of Gondar Referral Hospital, northwest Ethiopia...
2018: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/29718964/determinants-of-blood-pressure-control-amongst-hypertensive-patients-in-northwest-ethiopia
#18
Destaw Fetene Teshome, Amsalu Feleke Demssie, Berihun Megabiaw Zeleke
BACKGROUND: Controlling blood pressure (BP) leads to significant reduction in cardiovascular risks and associated deaths. In Ethiopia, data is scarce about the level and determinants of optimal BP control among hypertensive patients. This study aimed to assess the prevalence and associated factors of optimal BP control among hypertensive patients attending at a district hospital. METHODS: A hospital-based, cross-sectional study was conducted among 392 hypertensive patients who were on treatment and follow-up at a district hospital...
2018: PloS One
https://www.readbyqxmd.com/read/29717393/hypertension-in-developing-countries-a-major-challenge-for-the-future
#19
REVIEW
M Mohsen Ibrahim
PURPOSE OF REVIEW: Outline recent epidemiologic data regarding hypertension in developing countries, distinguish differences from developed countries, and identify challenges in management and future perspectives. RECENT FINDINGS: Increased sugar intake, air and noise pollution, and low birth weight are emerging hypertension risk factors. The major challenges in management are difficulties in accurate diagnosis of hypertension and adequate blood pressure control...
May 1, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29717388/dimerization-of-at-2-and-mas-receptors-in-control-of-blood-pressure
#20
REVIEW
Sanket Patel, Tahir Hussain
PURPOSE OF REVIEW: Angiotensin type 2 receptor (AT2 R) and receptor Mas (MasR) are part of the "protective arm" of the renin angiotensin system. Gene and pharmacological manipulation studies reveal that AT2 R and MasR are involved in natriuretic, vasodilatory, and anti-inflammatory responses and in lowering blood pressure in various animal models under normal and pathological conditions such as salt-sensitive hypertension, obesity, and diabetes. The scope of this review is to discuss co-localization and heterodimerization as potential molecular mechanisms of AT2 R- and MasR-mediated functions including antihypertensive activities...
May 1, 2018: Current Hypertension Reports
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