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https://www.readbyqxmd.com/read/29760195/neuron-specific-hur-deficient-mice-spontaneously-develop-motor-neuron-disease
#1
Kevin Sun, Xiao Li, Xing Chen, Ying Bai, Gao Zhou, Olga N Kokiko-Cochran, Bruce Lamb, Thomas A Hamilton, Ching-Yi Lin, Yu-Shang Lee, Tomasz Herjan
Human Ag R (HuR) is an RNA binding protein in the ELAVL protein family. To study the neuron-specific function of HuR, we generated inducible, neuron-specific HuR-deficient mice of both sexes. After tamoxifen-induced deletion of HuR, these mice developed a phenotype consisting of poor balance, decreased movement, and decreased strength. They performed significantly worse on the rotarod test compared with littermate control mice, indicating coordination deficiency. Using the grip-strength test, it was also determined that the forelimbs of neuron-specific HuR-deficient mice were much weaker than littermate control mice...
May 14, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29707428/rnai-mediated-knockdown-of-mtnr1b-without-disrupting-the-effects-of-melatonin-on-apoptosis-and-cell-cycle-in-bovine-granulose-cells
#2
Wenju Liu, Shujuan Wang, Jinxing Zhou, Xunsheng Pang, Like Wang
Melatonin is well known as a powerful free radical scavenger and exhibits the ability to prevent cell apoptosis. In the present study, we investigated the role of melatonin and its receptor MTNR1B in regulating the function of bovine granulosa cells (GCs) and hypothesized the involvement of MTNR1B in mediating the effect of melatonin on GCs. Our results showed that MTNR1B knockdown significantly promoted GCs apoptosis but did not affect the cell cycle. These results were further verified by increasing the expression of pro-apoptosis genes ( BAX and CASP3 ), decreasing expression of the anti-apoptosis genes ( BCL2 and BCL-XL ) and anti-oxidant genes ( SOD1 and GPX4 ) without affecting cell cycle factors ( CCND1 , CCNE1 and CDKN1A ) and TP53 ...
2018: PeerJ
https://www.readbyqxmd.com/read/29693124/regulation-of-the-expression-of-tumor-necrosis-factor%C3%A2-related-genes-by-abnormal-histone-h3k27-acetylation-implications-for-neural-tube-defects
#3
Chunlei Wan, Xiaozhen Liu, Baoling Bai, Haiyan Cao, Huili Li, Qin Zhang
The association between apoptosis and neural tube defects (NTDs) is recognized as important, however, the precise link remains to be elucidated. Epigenetic modifications in human NTDs have been detected previously. In the present study, the occurrence of epigenetic modifications in apoptosis‑related genes was investigated in a retinoic acid (RA)‑induced mouse NTD model. Among 84 key genes involved in programmed cell death, 13 genes, including tumor necrosis factor (Tnf), annexin A5, apoptosis inhibitor 5, Bcl2‑associated athanogene 3, baculoviral IAP repeat‑containing 3, caspase (Casp)12, Casp4, Casp8, lymphotoxin β receptor, NLR family, apoptosis inhibitory protein 2, TNF receptor superfamily (Tnfrsf)1a, TNF superfamily (Tnfs)f10 and Tnfsf12, were downregulated, whereas nucleolar protein 3 was upregulated in the RA‑induced NTD mice...
April 19, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29668843/effects-of-catecholamines-on-secretion-of-interferon-tau-and-expression-of-genes-for-synthesis-of-polyamines-and-apoptosis-by-ovine-trophectoderm
#4
Mohammed A Elmetwally, Yasser Lenis, Wanjin Tang, Guoyao Wu, Fuller W Bazer
Ovine trophectoderm (oTr1) cells were used to investigate effects of epinephrine (EP), norepinephrine (NE) and dopamine (DA) on their proliferation, migration and adhesion, secretion of interferon tau (IFNT), and expression of genes for synthesis of polyamines and apoptosis. Expression of mRNAs for agmatinase (AGMAT), arginine decarboxylase (ADC), ornithine decarboxylase (ODC1) and solute carrier family 7 (SLC7A1) cationic amino acid transporter, Y + system), member 1 increased (P < 0.05) in oTr1 cells in response to EP and DA...
April 12, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29661725/importin-%C3%AE-and-exportin-5-are-indicators-of-acute-viral-infection-correlation-of-their-detection-with-commercially-available-detection-kits
#5
Gerard J Nuovo, Cecilia Vianna de Andrade, Chandini Thirukkumaran, Alcina F Nicol
This work focused on immunohistochemistry markers of acute viral infections. Viral infected cells were detected by in situ based methods (reovirus, rabies virus) or cytologic changes (human papillomavirus, molloscum contagiosum virus, herpes simplex virus). Two proteins involved in nuclear trafficking, importin-β and exportin-5, were detected in the infected cells for each virus and not in the control tissues. A wide variety of other proteins, including caspase-3, and bcl-2 family members (bcl2, bclX, MCL1, BAK, BAX, BIM, BAD) showed wide variations in expression among the different viral infections...
January 10, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29623838/mir-29-targets-puma-to-suppress-oxygen-and-glucose-deprivation-reperfusion-ogd-r-induced-cell-death-in-hippocampal-neurons
#6
Rong Wei, Rufang Zhang, Hongmei Li, Hongyun Li, Saiji Zhang, Yewei Xie, Shen Li, Fang Chen
We previously demonstrate that microRNAs (miRNA) play an important role in hypothermic circulatory arrest (DHCA)-associated neural injury. However, the specific role of miRNAs in the pathogenesis of DHCA-induced neuron death is still unclear. Thus, in the present study, we investigated miR-29 expression and roles in neuronal HT-22 cells with oxygen-glucose deprivation/reoxygenation (OGD/R). In this study, the model of OGD/R was established using an airtight culture container and the anaeropack. Measurement of reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP) was used the probes of JC-1 and H2DCFDA...
April 3, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29621734/protective-effect-of-pristimerin-against-lps-induced-acute-lung-injury-in-mice
#7
Ahmed A Shaaban, Dalia H El-Kashef, Mohamed F Hamed, Dina S El-Agamy
Pristimerin (Pris) is a triterpenoid derivative obtained from Celastraceae and Hippocrateaceae families. This compound has been extensively tested for its potent anti-cancer activity against different types of tumors. However, its effects against acute lung injury (ALI) remain to be investigated. This study explored the efficacy of Pris to protect against lipopolysaccharide (LPS)-induced ALI and its possible pathways. Results have shown that Pris possesses potent protective activity against LPS-induced acute lung damage...
April 2, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29620273/p38-inhibitor-inhibits-the-apoptosis-of-cowanin-treated-human-colorectal-adenocarcinoma-cells
#8
Nittiya Chowchaikong, Sirinun Nilwarangkoon, Surat Laphookhieo, Chantra Tanunyutthawongse, Ramida Watanapokasin
Colorectal cancer, which is the third most common type of cancer diagnosed in both men and women, is the leading cause of cancer-related deaths worldwide. Cowanin is a pure compound extracted from Garcinia cowa Roxb., a tree species present in Thailand, Malaysia and Myanmar. The crude extract has been demonstrated to have antitumor activity, inflammation induction, antibacterial activity, anti-inflammatory activity and antimalarial activity. In the present study, the effects of cowanin on apoptosis induction and on the apoptosis-related and mitogen-activated protein kinase (MAPK) pathways were investigated in the LoVo human colorectal cancer cell line...
April 3, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29610564/effects-of-secreted-frizzled-related-protein-1-on-proliferation-migration-invasion-and-apoptosis-of-colorectal-cancer-cells
#9
Zhongchuan Wang, Rujia Li, Yongshan He, Shiyong Huang
Background: Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRPs family that modulates the Wnt signal transduction pathway. Recent studies have showed down-regulation of SFRP1 expression in colorectal cancer (CRC). We aimed to evaluate the effect of SFRP1 on the proliferation, migration, invasion and apoptosis of CRC cells in vitro. Materials and methods: We used real-time fluorescence quantification (RT-PCR) and Western blotting to detect SFRP1 expression in CRC, pericarcinomatous tissues and CRC cell lines...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29593724/mirnome-expression-analysis-reveals-new-players-on-leprosy-immune-physiopathology
#10
Claudio Guedes Salgado, Pablo Pinto, Raquel Carvalho Bouth, Angélica Rita Gobbo, Ana Caroline Cunha Messias, Tatiana Vinasco Sandoval, André Mauricio Ribeiro Dos Santos, Fabiano Cordeiro Moreira, Amanda Ferreira Vidal, Luiz Ricardo Goulart, Josafá Gonçalves Barreto, Moisés Batista da Silva, Marco Andrey Cipriani Frade, John Stewart Spencer, Sidney Santos, Ândrea Ribeiro-Dos-Santos
Leprosy remains as a public health problem and its physiopathology is still not fully understood. MicroRNAs (miRNA) are small RNA non-coding that can interfere with mRNA to regulate gene expression. A few studies using DNA chip microarrays have explored the expression of miRNA in leprosy patients using a predetermined set of genes as targets, providing interesting findings regarding the regulation of immune genes. However, using a predetermined set of genes restricted the possibility of finding new miRNAs that might be involved in different mechanisms of disease...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29589053/loss-of-wilms-tumor-1-protein-is-a-marker-for-apoptosis-in-response-to-replicative-stress-in-leukemic-cells
#11
Miriam Pons, Claudia M Reichardt, Dorle Hennig, Abinaya Nathan, Nicole Kiweler, Carol Stocking, Christian Wichmann, Markus Christmann, Falk Butter, Sigrid Reichardt, Günter Schneider, Thorsten Heinzel, Christoph Englert, Jörg Hartkamp, Oliver H Krämer, Nisintha Mahendrarajah
A remaining expression of the transcription factor Wilms tumor 1 (WT1) after cytotoxic chemotherapy indicates remaining leukemic clones in patients. We determined the regulation and relevance of WT1 in leukemic cells exposed to replicative stress and DNA damage. To induce these conditions, we used the clinically relevant chemotherapeutics hydroxyurea and doxorubicin. We additionally treated cells with the pro-apoptotic kinase inhibitor staurosporine. Our data show that these agents promote apoptosis to a variable extent in a panel of 12 leukemic cell lines and that caspases cleave WT1 during apoptosis...
March 27, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29562785/extracellular-vesicles-derived-from-wharton-s-jelly-mesenchymal-stem-cells-prevent-and-resolve-programmed-cell-death-mediated-by-perinatal-hypoxia-ischemia-in-neuronal-cells
#12
Marianne S Joerger-Messerli, Byron Oppliger, Marialuigia Spinelli, Gierin Thomi, Ivana di Salvo, Philipp Schneider, Andreina Schoeberlein
Hypoxic-ischemic (HI) insult in the perinatal phase harbors a high risk of encephalopathy in the neonate. Brain cells undergo apoptosis, initiating neurodegeneration. So far, therapeutic approaches such as cooling remain limited. Transplantation of mesenchymal stem cells (MSCs) exhibits therapeutic success despite the short-time survival in the host brain, providing strong evidence that their beneficial effects are largely based on secreted factors, including extracellular vesicles (EVs). The aim of this study was to investigate the effects of human Wharton's jelly MSC (hWJ-MSC)-derived EVs on neuroprotection and neuroregeneration, using an in vitro model of oxygen-glucose deprivation/reoxygenation (OGD/R) mimicking HI injury in the mouse neuroblastoma cell line neuro2a (N2a)...
January 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29511493/protective-effect-of-scutellarin-on-myocardial-infarction-induced-by-isoprenaline-in-rats
#13
Haibo Huang, Qianqian Geng, Hong Yao, Zhenhuang Shen, Zhenhong Wu, Xiaoqing Miao, Peiying Shi
Objectives: Scutellarin ( Scu ) is the main effective constituent of Erigeron breviscapus which has anti-oxidant, anti-apoptotic, anti-inflammatory and other therapeutic properties. The purpose of this study was to investigate the protective effect of Scu on myocardial infarction (MI) induced by isoprenaline (ISO). Materials and Methods: The rats were subcutaneously injected with ISO (45 mg/kg) on the first day, then single tail-intravenously injected with different doses of Scu (10 mg/kg, 20 mg/kg, 40 mg/kg) for 7 consecutive days...
March 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29507226/foxp1-controls-mature-b-cell-survival-and-the-development-of-follicular-and-b-1-b-cells
#14
Thomas Patzelt, Selina J Keppler, Oliver Gorka, Silvia Thoene, Tim Wartewig, Michael Reth, Irmgard Förster, Roland Lang, Maike Buchner, Jürgen Ruland
The transcription factor Foxp1 is critical for early B cell development. Despite frequent deregulation of Foxp1 in B cell lymphoma, the physiological functions of Foxp1 in mature B cells remain unknown. Here, we used conditional gene targeting in the B cell lineage and report that Foxp1 disruption in developing and mature B cells results in reduced numbers and frequencies of follicular and B-1 B cells and in impaired antibody production upon T cell-independent immunization in vivo. Moreover, Foxp1 -deficient B cells are impaired in survival even though they exhibit an increased capacity to proliferate...
March 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29498802/differential-effects-of-vav-promoter-driven-overexpression-of-bclx-and-bfl1-on-lymphocyte-survival-and-b-cell-lymphomagenesis
#15
EDITORIAL
Selma Tuzlak, Manuel D Haschka, Anna-Maria Mokina, Thomas Rülicke, Suzanne Cory, Verena Labi, Andreas Villunger
Overexpression of BCLX and BFL1/A1 has been reported in various human malignancies and is associated with poor prognosis and drug resistance, identifying these prosurvival BCL2 family members as putative drug targets. We have generated transgenic mice that express human BFL1 or human BCLX protein throughout the haematopoietic system under the control of the Vav gene promoter. Haematopoiesis is normal in both the Vav-BFL1 and Vav-BCLX transgenic (TG) mice and susceptibility to spontaneous haematopoietic malignancies is not increased...
April 2018: FEBS Journal
https://www.readbyqxmd.com/read/29496163/acetonic-extracts-of-the-endolichenic-fungus-el002332-isolated-from-endocarpon-pusillum-exhibits-anticancer-activity-in-human-gastric-cancer-cells
#16
Yi Yang, Woo Kyun Bae, Sang-Jip Nam, Min-Hye Jeong, Rui Zhou, So-Yeon Park, İsa Taş, Yun-Ho Hwang, Myong-Suk Park, Ik Joo Chung, Kyung Keun Kim, Jae-Seoun Hur, Hangun Kim
BACKGROUND: Endolichenic fungi are microbes that inhabit the thalli of lichens and produce various unique chemicals that can be used for pharmaceutical purposes. PURPOSE: This study screened a library of endolichenic fungal extracts to identify novel anticancer agents capable of suppressing the tumorigenicity of human cancer cells. METHODS: Active compounds were isolated from extracts of endolichenic fungi by column chromatography and reverse-phase HPLC...
February 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29483204/mir-103-107-promote-er-stress-mediated-apoptosis-via-targeting-the-wnt3a-%C3%AE-catenin-atf6-pathway-in-preadipocytes
#17
Zhenzhen Zhang, Song Wu, Saeed Muhammad, Qian Ren, Chao Sun
Both miR-103 and miR-107 have been demonstrated to restrain cell proliferation and regulate lipid metabolism and inflammation. However, the effects of miR-103/107 on preadipocyte apoptosis remain unknown. In the present research, we have investigated how miR-103/107 regulated preadipocyte apoptosis. We found that miR-103/107 aggravated endoplasmic reticulum (ER) stress-mediated apoptosis in preadipocytes. We confirmed that miR-103/107 targeted WNT family member 3a (Wnt3a) in preadipocytes. It was found that overexpressing Wnt3a resulted in suppression of ER stress-mediated apoptosis, while restoration of miR-103/107 counteracted the effects of Wnt3a in preadipocytes...
May 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29483196/grouper-iridovirus-giv66-is-a-bcl-2-protein-that-inhibits-apoptosis-by-exclusively-sequestering-bim
#18
Suresh Banjara, Jiahao Mao, Timothy M Ryan, Sofia Caria, Marc Kvansakul
Programmed cell death or apoptosis is a critical mechanism for the controlled removal of damaged or infected cells, and proteins of the Bcl-2 family are important arbiters of this process. Viruses have been shown to encode functional and structural homologs of Bcl-2 to counter premature host-cell apoptosis and ensure viral proliferation or survival. Grouper iridovirus (GIV) is a large DNA virus belonging to the Iridoviridae family and harbors GIV66, a putative Bcl-2-like protein and mitochondrially localized apoptosis inhibitor...
April 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29477371/venetoclax-a-new-wave-in-hematooncology
#19
REVIEW
Jana Mihalyova, Tomas Jelinek, Katerina Growkova, Matous Hrdinka, Michal Simicek, Roman Hajek
Inhibitors of antiapoptotic proteins of the BCL2 family can successfully restart the deregulated process of apoptosis in malignant cells. Whereas nonselective agents have been limited by their affinity to different BCL2 members, thus inducing excessive toxicity, the highly selective BCL2 inhibitor venetoclax (ABT-199, Venclexta™) has an acceptable safety profile. To date, it has been approved in monotherapy for the treatment of relapsed or refractory chronic lymphocytic leukemia (CLL) with 17p deletion. Extension of indications can be expected in monotherapy and in combination regimens...
May 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29467486/eric-recommendations-for-tp53-mutation-analysis-in-chronic-lymphocytic-leukemia-update-on-methodological-approaches-and-results-interpretation
#20
REVIEW
J Malcikova, E Tausch, D Rossi, L A Sutton, T Soussi, T Zenz, A P Kater, C U Niemann, D Gonzalez, F Davi, M Gonzalez Diaz, C Moreno, G Gaidano, K Stamatopoulos, R Rosenquist, S Stilgenbauer, P Ghia, S Pospisilova
In chronic lymphocytic leukemia (CLL), TP53 gene defects, due to deletion of the 17p13 locus and/or mutation(s) within the TP53 gene, are associated with resistance to chemoimmunotherapy and a particularly dismal clinical outcome. On these grounds, analysis of TP53 aberrations has been incorporated into routine clinical diagnostics to improve patient stratification and optimize therapeutic decisions. The predictive implications of TP53 aberrations have increasing significance in the era of novel targeted therapies, i...
May 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
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