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https://www.readbyqxmd.com/read/28918507/the-muscle-regulatory-transcription-factor-myod-participates-with-p53-to-directly-increase-the-expression-of-the-pro-apoptotic-bcl2-family-member-puma
#1
Terri J Harford, Greg Kliment, Girish C Shukla, Crystal M Weyman
The muscle regulatory transcription factor MyoD is a master regulator of skeletal myoblast differentiation. We have previously reported that MyoD is also necessary for the elevated expression of the pro-apoptotic Bcl2 family member PUMA, and the ensuing apoptosis, that occurs in a subset of myoblasts induced to differentiate. Herein, we report the identification of a functional MyoD binding site within the extended PUMA promoter. In silico analysis of the murine PUMA extended promoter revealed three potential MyoD binding sites within 2 kb of the transcription start site...
September 16, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28902352/gper-promotes-tamoxifen-resistance-in-er-breast-cancer-cells-by-reduced-bim-proteins-through-mapk-erk-trim2-signaling-axis
#2
Heng Yin, Qing Zhu, Manran Liu, Gang Tu, Qing Li, Jie Yuan, Siyang Wen, Guanglun Yang
Tamoxifen resistance is a major clinical challenge in breast cancer treatment. Our previous studies find that GPER and its down-stream signaling play a pivotal role in the development of tamoxifen (TAM) resistance. cDNA array analysis indicated a set of genes associated with cell apoptosis are aberrant in GPER activated and TAM-resistant MCF-7R cells compared with TAM-sensitive MCF-7 cells. Among these genes, Bim (also named BCL2-L11), a member of the BH3-only pro-apoptotic protein family is significantly decreased, and TRIM RING finger protein TRIM2 (a ubiquitin ligase) is highly expressed in MCF-7R...
September 5, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28895891/alignment-of-mitotic-chromosomes-in-human-cells-involves-sr-like-splicing-factors-btf-and-trap150
#3
Sapna Varia, Divya Cheedu, Michael Markey, Keshia Torres-Shafer, Vishnu Priya Battini, Athanasios Bubulya, Paula A Bubulya
Serine-arginine-rich (SR) or SR-like splicing factors interact with exon junction complex proteins during pre-mRNA processing to promote mRNA packaging into mature messenger ribonucleoproteins (mRNPs) and to dictate mRNA stability, nuclear export, and translation. The SR protein family is complex, and while many classical SR proteins have well-defined mRNA processing functions, those of other SR-like proteins is unclear. Here, we show that depletion of the homologous non-classical serine-arginine-rich (SR) splicing factors Bcl2-associated transcription factor (Btf or BCLAF) and thyroid hormone receptor-associated protein of 150 kDa (TRAP150) causes mitotic defects...
September 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28880942/live-cell-imaging-to-measure-bax-recruitment-kinetics-to-mitochondria-during-apoptosis
#4
Margaret E Maes, Cassandra L Schlamp, Robert W Nickells
The pro-apoptotic BCL2 gene family member, BAX, plays a pivotal role in the intrinsic apoptotic pathway. Under cellular stress, BAX recruitment to the mitochondria occurs when activated BAX forms dimers, then oligomers, to initiate mitochondria outer membrane permeabilization (MOMP), a process critical for apoptotic progression. The activation and recruitment of BAX to form oligomers has been studied for two decades using fusion proteins with a fluorescent reporter attached in-frame to the BAX N-terminus. We applied high-speed live cell imaging to monitor the recruitment of BAX fusion proteins in dying cells...
2017: PloS One
https://www.readbyqxmd.com/read/28864113/identification-of-apoptosis-related-genes-bcl2-and-bax-from-yellow-catfish-pelteobagrus-fulvidraco-and-their-transcriptional-responses-to-waterborne-and-dietborne-zinc-exposure
#5
Dan-Dan Li, Zhi Luo, Guang-Hui Chen, Yu-Feng Song, Chuan-Chuan Wei, Ya-Xiong Pan
Apoptosis plays a key role in the physiology of multicellular organisms, and has been well studied in mammals, but not in teleosts. Zinc (Zn) has been shown to be an important regulator of apoptosis and apoptosis involves in the regulation of lipid metabolism. Moreover, our recent study indicated that waterborne and dietborne Zn exposure differently influenced lipid metabolism in Pelteobagrus fulvidraco, but further mechanism remained unknown. The hypothesis of the present study is that apoptosis mediated the Zn-induced changes of lipid metabolism of P...
August 29, 2017: Gene
https://www.readbyqxmd.com/read/28855351/non-hodgkin-and-hodgkin-lymphomas-select-for-overexpression-of-bclw
#6
Clare M Adams, Ramkrishna Mitra, Jerald Gong, Christine M Eischen
PURPOSE: B-cell lymphomas must acquire resistance to apoptosis during their development. We recently discovered BCLW, an anti-apoptotic BCL2 family member thought only to contribute to spermatogenesis, was overexpressed in diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma. To gain insight into the contribution of BCLW to B-cell lymphomas and its potential to confer resistance to BCL2 inhibitors, we investigated the expression of BCLW and the other anti-apoptotic BCL2 family members in six different B-cell lymphomas...
August 29, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28851813/the-influential-role-of-bcl2-family-members-in-synovial-sarcomagenesis
#7
Jared J Barrott, Ju-Fen Zhu, Kyllie Smith-Fry, Asia M Susko, Dakota Nollner, Lance Burrell, Amir Pozner, Mario R Capecchi, Jeffrey T Yap, Lisa A Cannon-Albright, Xingming Deng, Kevin B Jones
Synovial sarcomas are deadly soft-tissue malignancies associated with t(X;18) balanced chromosomal translocations. Expression of the apoptotic regulator BCL2 is prominent in synovial sarcomas and has prompted the hypothesis that synovial sarcomagenesis may depend on it. Herein, it is demonstrated that Bcl2 overexpression enhances synovial sarcomagenesis in an animal model. Further, we determined increased familial clustering of human synovial sarcoma patients with victims of other BCL2-associated malignancies in the Utah Population Database...
August 29, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28831692/cold-inducible-protein-rbm3-protects-uv-irradiation-induced-apoptosis-in-neuroblastoma-cells-by-affecting-p38-and-jnk-pathways-and-bcl2-family-proteins
#8
Rui-Juan Zhuang, Jian Ma, Xiang Shi, Fei Ju, Shuang-Ping Ma, Lei Wang, Bin-Feng Cheng, Yan-Wen Ma, Mian Wang, Tong Li, Zhi-Wei Feng, Hai-Jie Yang
Induced by hypothermia, cold-inducible protein RBM3 (RNA-binding protein motif 3), has been implicated in neuroprotection against various toxic insults such as hypoxia and ischemia. However, whether mild hypothermia and RBM3 prevent neural cells from UV irradiation-elicited apoptosis is unclear. In the present study, human neuroblastoma cell line SH-SY5Y was used as a cell model for neural cell death, and it was demonstrated that mild hypothermia protects SH-SY5Y cells from UV irradiation-induced apoptosis...
August 22, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28799432/targeted-therapies-in-acute-myeloid-leukemia-a-focus-on-flt-3-inhibitors-and-abt199
#9
Kiran Naqvi, Marina Konopleva, Farhad Ravandi
Acute myeloid leukemia (AML) remains a therapeutic challenge. Despite ongoing research, the standard therapy for AML has not changed significantly in the past four decades. With the identification of cytogenetic and molecular abnormalities, several promising therapeutic agents are currently being investigated. FLT3 mutation is a well-recognized target seen in 30% of the cytogenetically normal AML. More recently, the BCL2 family of anti-apoptotic proteins have also generated great interest as a therapeutic target...
August 21, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28769046/kaiso-protects-human-umbilical-vein-endothelial-cells-against-apoptosis-by-differentially-regulating-the-expression-of-b-cell-cll-lymphoma-2-family-members
#10
Xiaodong Xue, Jian Zhang, Huai Lan, Yinli Xu, Huishan Wang
Endothelial cell injury can promote the development of various cardiovascular diseases, thus, fully understanding the mechanisms underlying the maintenance of vascular endothelial cell homoeostasis may help prevent and treat cardiovascular disease. Kaiso, a zinc finger and BTB domain containing transcription factor, is key to embryonic development and cancer, but how Kaiso interacts with vascular endothelium is not fully understood. We report that Kaiso has an anti-apoptotic function in human umbilical vein endothelial cells (HUVECs) and human microvascular endothelial cells (HMEC-1s)...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28765546/integrative-whole-genome-sequence-analysis-reveals-roles-of-regulatory-mutations-in-bcl6-and-bcl2-in-follicular-lymphoma
#11
Kirill Batmanov, Wei Wang, Magnar Bjørås, Jan Delabie, Junbai Wang
The contribution of mutations in regulatory regions to tumorigenesis has been the subject of many recent studies. We propose a new framework for integrative analysis of genome-wide sequencing data by considering diverse genetic information. This approach is applied to study follicular lymphoma (FL), a disease for which little is known about the contribution of regulatory gene mutations. Results from a test FL cohort revealed three novel highly recurrent regulatory mutation blocks near important genes implicated in FL, BCL6 and BCL2...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739740/global-analysis-of-mirna-mrna-interaction-network-in-breast-cancer-with-brain-metastasis
#12
Zhixin Li, Zhiqiang Peng, Siyu Gu, Junfang Zheng, Duiping Feng, Qiong Qin, Junqi He
BACKGROUND: MicroRNAs (miRNAs) have been linked to a number of cancer types including breast cancer. The rate of brain metastases is 10-30% in patients with advanced breast cancer which is associated with poor prognosis. The potential application of miRNAs in the diagnostics and therapeutics of breast cancer with brain metastasis is an area of intense interest. In an initial effort to systematically address the differential expression of miRNAs and mRNAs in primary breast cancer which may provide clues for early detection of brain metastasis, we analyzed the consequent changes in global patterns of gene expression in Gene Expression Omnibus (GEO) data set obtained by microarray from patients with in situ carcinoma and patients with brain metastasis...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28710745/the-pan-bcl2-inhibitor-at101-activates-the-intrinsic-apoptotic-pathway-and-causes-dna-damage-in-acute-myeloid-leukemia-stem-like-cells
#13
Leisi Zhang, Yong Zhou, Kai Chen, Pengcheng Shi, Yin Li, Manman Deng, Zhiwu Jiang, Xiangmeng Wang, Peng Li, Bing Xu
BACKGROUND: Leukemia stem cells (LSCs) are considered to be the cause of treatment failure and relapse in acute myeloid leukemia (AML). Overexpression of the Bcl-2 family of anti-apoptotic proteins such as Bcl-2, Bcl-xl, and Mcl-1 accounts for survival and self-renewal of LSCs. AT101 binds to the BH3 motif of all Bcl-2 family anti-apoptotic proteins and demonstrates anti-tumor activity in multiple types of tumor. Thus, we hypothesized that this agent might have the potential to deplete LSCs...
July 14, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28709980/downregulation-of-usp18-inhibits-growth-and-induces-apoptosis-in-hepatitis-b-virus-related-hepatocellular-carcinoma-cells-by-suppressing-bcl2l1
#14
Jing Cai, Tiande Liu, Xiaoliu Jiang, Changkuo Guo, Anwen Liu, Xinlan Xiao
Ubiquitin-specific peptidase 18 (USP18) is closely related with hepatitis B virus (HBV), which has been involved in tumourigenesis. However, there has been little research into the role of USP18 on the progression of hepatocellular carcinoma (HCC), especially in HBV-related HCC. In present study, we found that USP18 expression was aberrantly elevated in HCC tissues than adjacent non-tumour tissues. Importantly, USP18 expression was higher in HBV-related HCC cell lines (HepG2.2.15 and Hep3B) than HBV-unrelated HCC cell lines...
July 12, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28689336/v79-fibroblasts-are-protected-against-reactive-oxygen-species-by-flax-fabric
#15
Katarzyna Skórkowska-Telichowska, Anna Kulma, Tomasz Gębarowski, Wioleta Wojtasik, Kamil Kostyn, Helena Moreira, Anna Szyjka, Aleksandra Boba, Marta Preisner, Justyna Mierziak, Malgorzata Arendt, Anna Kostyn, Michał Szatkowski, Jan Szopa, Kazimierz Gąsiorowski
Chinese hamster pulmonary fibroblasts (V79 cells) pre-treated with flax fabrics derived from non-modified or genetically engineered flax fibres and treated with H2O2 revealed a markedly lower level of intracellular reactive oxygen species (ROS) than control, non-pre-treated cells. The fabrics were prepared from fibres derived from two kinds of transgenic plants: W92 plants, which overproduce flavonoids, and M type plants, which produce hydroxybutyrate polymer in their vascular bundles and thus in fibres. Incubating the V79 cells with the flax fabrics prior to H2O2 treatment also reduced the amount of DNA damage, as established using the comet assay (also known as alkaline single-cell gel electrophoresis) and pulsed-field electrophoresis of intact cellular DNA...
July 8, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28684422/curcumin-shifts-ras-induced-pro-proliferative-mek-erk-signaling-toward-pro-apoptotic-p38mapk-jnk1-signaling-triggering-p53-activation-and-apoptosis
#16
Shuvomoy Banerjee, Pushpak Bhattacharjee, Juni Chakraborty, Abir K Panda, Arnab Bandyopadhyay, Suman K Banik, Gaurisankar Sa
Oncogenic RAS is primarily associated with potent mitogenic ability, and RAS mutants also have an apoptogenic activity, which is poorly understood. Therefore, exploring the signaling circuit that shifts RAS-signals from pro-proliferative to death pathways may provide some molecular clues to the missing link between the mitogenic and apoptogenic mechanisms. Here, we used a systems biology approach exploiting microarray data and employing a mathematical model to better understand the dual role of oncogenic RAS This approach revealed that a curcumin-based intervention shifts the oncogenic RAS-induced MEK/ERK pro-proliferative pathway toward p38MAPK/JNK1 pro-death signaling...
July 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28672935/next-generation-sequencing-reveals-lymph-node-metastasis-associated-genetic-markers-in-colorectal-cancer
#17
Ni Xie, Yujiang Yao, Lili Wan, Ting Zhu, Litao Liu, Jianhui Yuan
Colorectal cancer is the third most prevalent type of cancer in the United States. Early diagnosis of lymph node metastases is essential to improve the prognosis for patients with colorectal cancer. Therefore, the present study aimed to screen genetic markers, including single nucleotide polymorphisms (SNPs), copy number variations (CNVs) and mRNA expression, associated with lymph node metastases in patients with colorectal cancer to enable an early diagnosis. Targeted next-generation sequencing was applied to capture SNPs and CNVs in tumor-related candidate genes within tumor tissues from 39 colorectal cancer patients; reverse transcription-quantitative polymerase chain reaction was used to detect the specific mRNA level of tumor-related candidate genes, including vascular endothelial growth factor C, cyclin-A2, Interleukin-2, ATP-binding cassette sub-family G member 2, epidermal growth factor (EGF) and nuclear factor kappa B subunit 1 (NFKB1) on chromosome 4...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28656307/sirt6-inhibits-growth-of-gastric-cancer-by-inhibiting-jak2-stat3-pathway
#18
Jianmei Zhou, Ang Wu, Xiaoting Yu, Jianwei Zhu, Hui Dai
SIRT6, a member of NAD positivity-dependent class III deacetylase sirtuin family, played versatile roles in human cancers. However, the expression and biological function of SIRT6 in gastric cancer (GC) remain to be investigated. In this study, we found that SIRT6 expression level was decreased in gastric cancer tissues and cell lines. Decreased SIRT6 expression was associated with unfavorable clinical parameters including tumor differentiation, tumor size and TNM stage. Importantly, decreased level of SIRT6 was associated with decreased rate of overall survival (OS) and disease‑free survival (DFS)...
June 27, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28653878/sirtuin-6-plays-an-oncogenic-role-and-induces-cell-autophagy-in-esophageal-cancer-cells
#19
Nan Huang, Zhiwei Liu, Jiabei Zhu, Zhongqi Cui, Yuguang Li, Yongchun Yu, Fenyong Sun, Qiuhui Pan, Qingyuan Yang
Sirtuin 6, a member of sirtuin family, is generally regarded as a tumor suppressor as it participates in suppressing hypoxia-inducible factor 1α and MYC transcription activity by deacetylating H3K9 (histone H3 lysine 9) and H3K56 (histone H3 lysine) at promoters of target genes, leading to the aerobic glycolysis inhibition and cell growth suppression. However, its expression has recently been reported to be highly elevated in a series of tumors, including prostate cancer, breast cancer, and non-small cell lung cancer, indicating that sirtuin 6 plays dual roles in tumorigenicity in a cell/tumor type-specific manner...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28618116/differences-in-p53-status-significantly-influence-the-cellular-response-and-cell-survival-to-1-25-dihydroxyvitamin-d3-metformin-cotreatment-in-colorectal-cancer-cells
#20
Mohamed A Abu El Maaty, Wendy Strassburger, Tooba Qaiser, Yasamin Dabiri, Stefan Wölfl
Mutations in the tumor suppressor p53 are highly prevalent in cancers and are known to influence the sensitivity of cells to various chemotherapeutics including the anti-cancer candidates 1,25-dihydrovitamin D3 [1,25D3] and metformin. Previous studies have demonstrated additive/synergistic anti-cancer effects of the 1,25D3-metformin combination in different models, however the influence of p53 status on the efficacy of this regimen has not been investigated. The CRC cell lines HCT116 wild-type (wt), HCT116 p53-/- and HT-29 (mutant; R273H) were employed, covering 3 different p53 variations...
June 15, 2017: Molecular Carcinogenesis
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