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https://www.readbyqxmd.com/read/29906310/a-randomized-pharmacokinetic-and-pharmacodynamic-evaluation-of-every-8-hour-and-12-hour-dosing-strategies-of-vancomycin-and-cefepime-in-neurocritically-ill-patients
#1
Lynn E Kassel, Edward T Van Matre, Charles J Foster, Douglas N Fish, Scott W Mueller, Deb S Sherman, Michael F Wempe, Robert MacLaren, Robert T Neumann, Tyree H Kiser
PURPOSE: Neurocritically-ill patients have clinically significant alterations in pharmacokinetic parameters of renally-eliminated medications, which may result in subtherapeutic plasma and cerebrospinal fluid antibiotic concentrations. METHODS: Prospective, randomized, open-label study of adult neurocritically-ill patients treated with vancomycin and cefepime. Vancomycin 15 mg/kg and cefepime 2 g were dosed at every 8 or 12-hour intervals. The primary outcomes were the achievement of pharmacodynamic targets related to time of unbound drug above minimum inhibitory concentrations (MIC) for 60% or more of the dosing interval (fT>MIC ≥60%) for β-lactams and ratio of 24-hour area under the curve (AUC):MIC of 400 or greater for vancomycin...
June 15, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29905968/skeletal-consequences-of-nephropathic-cystinosis
#2
Pablo Florenzano, Carlos Ferreira, Galina Nesterova, Mary Scott Ramnitz, Sri Harsha Tella, Luis Fernandez de Castro, Sydney M Brown, Adom Whitaker, Renata C Pereira, Dorothy Bulas, Rachel I Gafni, Isidro B Salusky, William A Gahl, Michael T Collins
Nephropathic cystinosis is a rare lysosomal storage disorder. Patients present in the first year of life with renal Fanconi syndrome that evolves to progressive chronic kidney disease (CKD). Despite the multiple risk factors for bone disease, the frequency and severity of skeletal disorders in nephropathic cystinosis have not been described. We performed systematic bone and mineral evaluations of subjects with cystinosis seen at the NIH (N = 30), including history and physical examination, serum and urine biochemistries, DXA, vertebral fracture assessment, skeletal radiographs, and renal ultrasound...
June 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29905961/treatment-planning-algorithm-for-prrt-considering-multiple-tumor-lesions-and-organs-at-risk
#3
Luis David Jiménez-Franco, Peter Kletting, Ambros J Beer, Gerhard Glatting
PURPOSE: Peptide receptor radionuclide therapy (PRRT) has shown promising results in the treatment of tumors with high expression of somatostatin receptors such as neuroendocrine tumors (NETs) and meningioma. However, PRRT potentially produces high renal and red marrow (RM) toxicity, the kidneys usually being the dose-limiting organ. Previously, it was shown that an improved therapeutic index can be achieved by choosing an optimal combination of injected activity and peptide molar amount...
June 15, 2018: Medical Physics
https://www.readbyqxmd.com/read/29902327/epstein-barr-virus-infection-was-associated-with-nephrotic-syndrome-severe-thrombocytopenia-and-coombs-positive-haemolytic-anaemia
#4
Ahmad Amer, Maital Kaidar, Diana Tasher, Amir Lotan, Ilan Dalal
Epstein Barr virus (EBV) infections include a wide spectrum of clinical manifestations, ranging from asymptomatic to multiple organ involvement (1). Several complications have been described and renal involvement is usually nephritic and not nephrotic. Nephritic includes haematuria, proteinuria, renal impairment and salt retention causing hypertension and oedema, while nephrotic is defined as heavy proteinuria, with a protein/creatinine ratio of >200 mg/mmol, hypoalbuminemia of <25 g/L and oedema (2-4)...
June 14, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29900661/allograft-and-patient-survival-after-sequential-hsct-and-kidney-transplantation-from-the-same-donor-a-multicenter-analysis
#5
Michael Eder, Christoph Schwarz, Michael Kammer, Niels Jacobsen, Stavroula Masouridi Levrat, Morton J Cowan, Tepsiri Chongkrairatanakul, Robert Gaston, Rommel Ravanan, Hideki Ishida, Anette Bachmann, Sergio Alvarez, Martina Koch, Cyril Garrouste, Ulrich A Duffner, Brett Cullis, Nicolaas Schaap, Michael Medinger, Søren Schwartz Sørensen, Eva-Maria Dauber, Georg Böhmig, Heinz Regele, Gabriela A Berlakovich, Thomas Wekerle, Rainer Oberbauer
Tolerance induction through simultaneous hematopoietic stem cell- and renal transplantation has shown promising results, but it is hampered by the toxicity of preconditioning therapies and graft-versus-host disease. Moreover, renal function has never been compared to conventionally transplanted patients, thus, whether donor-specific tolerance results in improved outcomes remains unanswered. We collected follow-up data of published cases of renal transplantations after hematopoietic stem cell transplantation from the same donor and compared patient- and transplant kidney survival- as well as function with caliper-matched living-donor renal transplantations from the Austrian dialysis and transplant registry...
June 13, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29897139/pathologic-staging-of-renal-cell-carcinoma-a-review-of-300-consecutive-cases-with-emphasis-on-retrograde-venous-invasion
#6
Kanika Taneja, Sohrab Arora, Craig G Rogers, Nilesh S Gupta, Sean R Williamson
AIMS: Pathologic staging of renal cell carcinoma (RCC) can be challenging compared to other cancer types, as invasion often manifests as finger-like protrusions into vascular spaces or renal sinus tissue. Although prior studies have shown larger tumour size to be highly correlated with renal sinus invasion, prospective data on evaluating pathologic stage are limited. We evaluated a large series reported by a single urologic pathologist. METHODS AND RESULTS: Three hundred consecutive specimens were reviewed...
June 13, 2018: Histopathology
https://www.readbyqxmd.com/read/29896907/modulating-atp-binding-cassette-abc-transporters-in-papillary-renal-cell-carcinoma-type-2-enhances-its-response-to-targeted-molecular-therapy
#7
Rola M Saleeb, Mina Farag, Zsuzsanna Lichner, Fadi Brimo, Jenni Bartlett, Georg Bjarnason, Antonio Finelli, Fabio Rontondo, Michelle R Downes, George M Yousef
Papillary renal cell carcinoma (PRCC) is the most common non-clear cell RCCs and is known to comprise two histological subtypes. PRCC2 is more aggressive and is molecularly distinct from the other subtypes. Despite this PRCCs are treated together as one entity, and they show poor response to the current therapies that do not target pathways implicated in their pathogenesis. We have previously detected ABCC2 (an ABC transporter), VEGF and mTOR pathways to be enriched in PRCC2. In this study, we assess the therapeutic potential of targeting these pathways in PRCC2...
June 13, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29896858/prediction-of-bk-viremia-by-urine-viral-load-in-renal-transplant-patients-an-analysis-of-bk-viral-load-results-in-paired-urine-and-plasma-samples
#8
Kathleen Madden, Charles Janitell, Daniel Sower, Shangxin Yang
BK virus (BKPyV) associated nephropathy (BKPyVAN) may affect up to 10% of renal transplant recipients, causing graft failure in the absence of intervention. The dilemma in monitoring BKPyVAN in renal transplant patients has been that only testing urine BK viral load represents higher sensitivity (earlier detection) but lower specificity, while testing plasma BK viral load represents lower sensitivity (later detection) but higher specificity. However, blindly testing both urine and plasma inevitably contributes to unnecessary medical cost...
June 13, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29896763/renal-in-patient-ward-nurse-experience-and-job-satisfaction-a-qualitative-study
#9
Aisha Tamika McKenzie, Gulen Addis
AIMS AND OBJECTIVES: The aim of this study was to examine the experience of registered nurses working in renal inpatients wards at an acute National Health Service (NHS) hospital Trust. Nurse perceptions of their experience particularly in relation to job satisfaction was analysed. BACKGROUND: Increased understanding of workplace organisation and culture can contribute to improved nurse work experience and better patient care. Worldwide many studies conducted on nurse experience and job satisfaction show that job satisfaction level varies across work settings so analysis of job satisfaction at a local level such as in a ward is important for producing useful analysis and recommendations...
June 13, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29893460/thromboembolic-risk-after-lumbar-spine-surgery-a-cohort-study-of-325-000-french-patients
#10
Benjamin Bouyer, Annie Rudnichi, Rosemary Dray-Spira, Mahmoud Zureik, Joël Coste
BACKGROUND: Post-operative venous thromboembolism (VTE) is a severe complication, the risk of which after lumbar spine surgery (LBS) is not precisely known. OBJECTIVE: To estimate the incidence of VTE after LBS and to identify individual and surgical risk factors. METHODS: All patients over the age of 18 years who underwent LBS in France between 2009 and 2014 were identified. Among 477,024 patients screened, exclusions concerned recent VTE or surgery and multiple surgeries during the same hospital stay...
June 12, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29893433/the-1-year-renal-biopsy-index-1-rbi-a-scoring-system-to-drive-biopsy-indication-at-1-year-post-kidney-transplantation
#11
REVIEW
Magali Giral, Karine Renaudin, Maarten Naesens, Redmer Luning, Dany Anglicheau, Emmanuel Morelon, Alexandre Huneau, Chloé Paul, Sophie Brouard, Grégoire Couvrat-Desvergnes, Yohann Foucher, Etienne Dantan
Surveillance biopsies after renal transplantation remain debatable. To drive the decision of such intervention, we propose a predictive score of abnormal histology at 1-year post-transplantation, named 1-Year Renal Biopsy Index (1-RBI). We studied 466 kidney recipients from the DIVAT cohort alive with a functioning graft and a surveillance biopsy at 1-year post-transplantation. Patients displaying abnormal histology (49%) (borderline, acute rejection, IFTA grade 2 or 3, glomerulonephritis) were compared to the normal or subnormal (IFTA grade 1) histology group...
June 12, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29892792/the-renal-blood-flow-reserve-in-healthy-humans-and-patients-with-atherosclerotic-renovascular-disease-measured-by-positron-emission-tomography-using-15-o-h-2-o
#12
Johanna Päivärinta, Niina Koivuviita, Vesa Oikonen, Hidehiro Iida, Kaisa Liukko, Ilkka Manner, Eliisa Löyttyniemi, Pirjo Nuutila, Kaj Metsärinne
BACKGROUND: Microvascular function plays an important role in ARVD (atherosclerotic renovascular disease). RFR (renal flow reserve), the capacity of renal vasculature to dilate, is known to reflect renal microvascular function. In this pilot study, we assessed PET (positron emission tomography)-based RFR values of healthy persons and renal artery stenosis patients. Seventeen patients with ARVD and eight healthy subjects were included in the study. Intravenous enalapril 1 mg was used as a vasodilatant, and the maximum response (blood pressure and RFR) to it was measured at 40 min...
June 11, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29888810/short-and-midterm-results-for-internal-jugular-vein-extension-for-short-right-renal-vein-kidney-transplant
#13
Tony Lu, Stephanie G Yi, Jean Bismuth, Richard J Knight, A Osama Gaber, Carlos F Bechara
Renal transplantation remains the definitive treatment for end stage renal disease (ESRD). The shorter renal vein in right donor nephrectomies is associated with higher incidence of technical failure. We present here our experience with autologous internal jugular vein (IJV) conduits to facilitate living-donor transplants. Six patients underwent right, living-donor kidney transplant with simultaneous IJV harvest over a one year period. All had bilateral jugular duplex scans preoperatively, and were placed on aspirin 81 mg postoperatively...
June 11, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29888547/efficacy-and-safety-of-dapagliflozin-in-patients-with-type-2-diabetes-and-moderate-renal-impairment-chronic-kidney-disease-stage-3a-the-derive-study
#14
Paola Fioretto, Stefano Del Prato, John B Buse, Ronald Goldenberg, Francesco Giorgino, Daniel Reyner, Anna Maria Langkilde, C David Sjӧstrӧm, Peter Sartipy
AIMS: Dapagliflozin is a selective inhibitor of sodium glucose co-transporter 2 (SGLT2). This study assessed the efficacy and safety of dapagliflozin 10 mg versus placebo in patients with type 2 diabetes (T2D) and moderate renal impairment (estimated glomerular filtration rate [eGFR] 45-59 mL/min/1.73m2 ; chronic kidney disease [CKD] stage 3A). MATERIALS AND METHODS: In this double-blind, parallel group, Phase 3 study (NCT02413398, clinicaltrials.gov) patients with inadequately controlled T2D (HbA1c 7...
June 11, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29888479/unmasking-and-aggravation-of-polycythemia-vera-by-canagliflozin
#15
L Das, A Bhansali, R Walia
BACKGROUND: Sodium-glucose co-transporter-2 inhibitors are novel antidiabetes drugs that act via inhibition of renal glucose reabsorption. This action causes osmotic diuresis, reduces intravascular volume and is associated with various adverse effects. In the present paper, we describe the first report on the unmasking of underlying polycythemia vera by canagliflozin in a person with Type 2 diabetes mellitus, which was temporally related to the use of the drug. CASE REPORT: A 51-year-old obese man with Type 2 diabetes was prescribed canagliflozin 100 mg for control of his glycaemia...
June 11, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29888426/differential-response-to-renal-replacement-therapy-in-neonatal-onset-inborn-errors-of-metabolism
#16
Francesco Porta, Licia Peruzzi, Roberto Bonaudo, Silvia Pieretti, Marta Busso, Enrico Cocchi, Alessandra Conio, Veronica Pagliardini, Marco Spada
Severe urea cycle defects (UCDs), organic acidemias (OAs), and maple syrup urine disease (MSUD) are life-threatening disorders presenting in the first days of life. Renal replacement therapy (RRT) is an emergency option in affected newborns, mostly performed as ultima ratio. We report our 10-year experience using emergency RRT in newborns with UCDs, OAs, and MSUD. Twelve newborns (8 with UCDs, 2 with methylmalonic acidemia, and 2 with MSUD) underwent emergency RRT. The overall survival rate to RRT was 58.3%...
June 10, 2018: Nephrology
https://www.readbyqxmd.com/read/29888403/genotype-phenotype-correlations-of-low-frequency-variants-in-the-complement-system-in-renal-disease-and-age-related-macular-degeneration
#17
M J Geerlings, E B Volokhina, E K de Jong, N van de Kar, M Pauper, C B Hoyng, L P van den Heuvel, A I den Hollander
Genetic alterations in the complement system have been linked to a variety of diseases, including atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy (C3G), and age-related macular degeneration (AMD). We performed sequence analysis of the complement genes CFH, CFI, and C3 in 866 aHUS/C3G and 697 AMD patients. In total we identified 505 low frequency alleles, representing 121 unique variants, of which 51 are novel. CFH contained the largest number of unique low frequency variants (n=64; 53%), followed by C3 (n=32; 26%) and CFI (n=25; 21%)...
June 11, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29884487/a-role-for-very-low-dose-recombinant-activated-factor-vii-in-refractory-bleeding-after-cardiac-surgery-lessons-from-an-observational-study
#18
Till Hoffmann, Alexander Assmann, Angelika Dierksen, Elisabeth Roussel, Sebastian Ullrich, Artur Lichtenberg, Alexander Albert, Stephan Sixt
OBJECTIVES: Although off-label use of recombinant activated factor VII against refractory bleeding is incorporated in current guideline recommendations, safety concerns persist predominantly with respect to thromboembolic complications. We analyzed the safety and efficacy of recombinant activated factor VII at a very low dose in cardiosurgical patients with refractory bleeding. METHODS: This prospective study includes 1180 cardiosurgical patients at risk of bleeding...
April 18, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29883532/innovative-use-of-novel-biomarkers-to-improve-the-safety-of-renally-eliminated-and-nephrotoxic-medications
#19
Erin F Barreto, Andrew D Rule, Stacy A Voils, Sandra L Kane-Gill
Over the last decade, the discovery and research into the application of novel renal biomarkers to improve medication efficacy and safety has expanded considerably. Pharmacists are uniquely positioned to leverage this new technology for renal assessment to improve medication dosing and monitoring. Serum cystatin C is a relatively new, inexpensive, functional renal biomarker that responds more quickly to changing renal function than creatinine and is not meaningfully affected by age, sex, skeletal muscle mass, dietary intake, or deconditioning...
June 8, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29882248/quantitative-global-proteome-and-lysine-succinylome-analyses-reveal-the-effects-of-energy-metabolism-in-renal-cell-carcinoma
#20
Naiwen Zhang, Ruxu Gao, Jianyu Yang, Yuyan Zhu, Zhe Zhang, Xiaolong Xu, Jianfeng Wang, Xiankui Liu, Zeliang Li, Zhenhua Li, Daxin Gong, Jun Li, Jianbin Bi, Chuize Kong
In light of the increasing incidence of renal cell carcinoma (RCC), its molecular mechanisms have been comprehensively explored in numerous recent studies. However, few studies focus on the influence of multi-factor interactions during the occurrence and development of RCC. The rapid development of mass spectrometry techniques enables an integrated and quantitative perspective on cancer mechanisms at the global protein level. In this study, we report the qualitative and quantitative profile of the proteome and the lysine succinylome in RCC...
June 7, 2018: Proteomics
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