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https://www.readbyqxmd.com/read/27881716/influence-of-route-of-administration-and-lipidation-of-apolipoprotein-a-i-peptide-on-pharmacokinetics-and-cholesterol-mobilization
#1
Jie Tang, Dan Li, Lindsey Drake, Wenmin Yuan, Sarah Deshaine, Emily E Morin, Rose Ackermann, Karl Olsen, David E Smith, Anna Schwendeman
Apoliprotein A-I (apoA-I), apoA-I mimetic peptides and their lipid complexes or reconstituted high-density lipoprotein (HDL) have been studied as treatments for various pathologies. However, consensus is lacking about the best method for administration - by intravenous (IV) or intra-peritoneal (IP) routes, and formulation - as an HDL particle or in a lipid-free form. The objective of this study was to systematically examine peptide plasma levels, cholesterol mobilization and lipoprotein remodeling in vivo following administration of lipid-free apoA-I peptide (22A) or phospholipid reconstituted 22A-sHDL by IV and IP routes...
November 23, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27801847/different-susceptibilities-between-apoe-and-ldlr-deficient-mice-to-inflammation-associated-colorectal-carcinogenesis
#2
Takuji Tanaka, Takeru Oyama, Shigeyuki Sugie, Masahito Shimizu
Hypercholesterolemia resulting in atherosclerosis is associated with an increased risk of ischemic heart disease and colorectal cancer (CRC). However, the roles of apoliprotein (Apo) E (Apoe) and low-density lipoprotein (Ldl) receptor (Ldlr) in colorectal carcinogenesis have not yet been investigated. In this study, we examined the susceptibility of Apoe-deficient and Ldlr-deficient mice, which are genetic animal models of atherosclerosis to azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colorectal carcinogenesis...
October 28, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27646300/obese-dogs-with-and-without-obesity-related-metabolic-dysfunction-a-proteomic-approach
#3
Asta Tvarijonaviciute, Jose J Ceron, Carlos de Torre, Blanka B Ljubić, Shelley L Holden, Yann Queau, Penelope J Morris, Josep Pastor, Alexander J German
BACKGROUND: Approximately 20 % of obese dogs have metabolic disturbances similar to those observed in human metabolic syndrome, a condition known as obesity-related metabolic dysfunction. This condition is associated with insulin resistance and decreased circulating adiponectin concentrations, but clinical consequences have not been reported. In order to define better the metabolic changes associated with obesity-related metabolic dysfunction (ORMD), we compared the plasma proteomes of obese dogs with and without ORMD...
September 20, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27597180/relative-abundance-of-apoe-and-a%C3%AE-1-42-associated-with-abnormal-prion-protein-differs-between-creutzfeldt-jakob-disease-subtypes
#4
Roger A Moore, Young Pyo Choi, Mark W Head, James W Ironside, Robert Faris, Diane L Ritchie, Gianluigi Zanusso, Suzette A Priola
Aggregated and protease-resistant mammalian prion protein (PrP(Sc)) is the primary protein component of infectious prions. Enriched PrP(Sc) preparations are often used to study the mechanisms that underly prion disease. However, most enrichment procedures are relatively nonspecific and tend to yield significant amounts of non-PrP(Sc) components including various proteins that could confound functional and structural studies. It is thus important to identify these proteins and assess their potential relevance to prion pathogenesis...
September 30, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27501155/cognitive-decline-in-the-elderly-after-surgery-and-anaesthesia-results-from-the-oxford-project-to-investigate-memory-and-ageing-optima-cohort
#5
D Patel, A D Lunn, A D Smith, D J Lehmann, K L Dorrington
Concerns have been raised about the effects on cognition of anaesthesia for surgery, especially in elderly people. We recorded cognitive decline in a cohort of 394 people (198 women) with median (IQR) age at recruitment of 72.6 (66.6-77.8) years, of whom 109 had moderate or major surgery during a median (IQR) follow-up of 4.1 (2.0-7.6) years. Cognitive decline was more rapid in people who on recruitment were: older, p = 0.0003; male, p = 0.027; had worse cognition, p < 0.0001; or carried the ε4 allele of apoliprotein E (APOEε4), p = 0...
October 2016: Anaesthesia
https://www.readbyqxmd.com/read/27297947/novel-type-of-renal-amyloidosis-derived-from-apolipoprotein-cii
#6
Samih H Nasr, Surendra Dasari, Linda Hasadsri, Jason D Theis, Julie A Vrana, Morie A Gertz, Prasuna Muppa, Michael T Zimmermann, Karen L Grogg, Angela Dispenzieri, Sanjeev Sethi, W Edward Highsmith, Giampaolo Merlini, Nelson Leung, Paul J Kurtin
Amyloidosis is characterized by extracellular deposition of misfolded proteins as insoluble fibrils. Most renal amyloidosis cases are Ig light chain, AA, or leukocyte chemotactic factor 2 amyloidosis, but rare hereditary forms can also involve the kidneys. Here, we describe the case of a 61-year-old woman who presented with nephrotic syndrome and renal impairment. Examination of the renal biopsy specimen revealed amyloidosis with predominant involvement of glomeruli and medullary interstitium. Proteomic analysis of Congo red-positive deposits detected large amounts of the Apo-CII protein...
June 13, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27082998/bacillus-produced-surfactin-attenuates-chronic-inflammation-in-atherosclerotic-lesions-of-apoe-mice
#7
Ping Gan, Dong Jin, Xiuyun Zhao, Zhenqiu Gao, Shengying Wang, Peng Du, Gaofu Qi
Bacillus-produced surfactin can inhibit acute inflammation in vitro and in vivo. However, there is no report whether surfactin could inhibit chronic inflammation in the atherosclerotic lesions. Apoliprotein E deficient (ApoE(-/-)) mice (fed on atherogenic diet) were intragastrically administered with surfactin for 9 doses, then the athero-protective effect of surfactin was determined in vivo. The results showed surfactin could induce anti-inflammatory factors such as IgA, transforming growth factor (TGF)-β and interleukin (IL)-10 in the intestine...
June 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27015844/the-mechanism-of-apoliprotein-a1-down-regulated-by-hepatitis-b-virus
#8
Yuanyuan Wang, Junli Hao, Xiaohong Liu, Hongxin Wang, Xin Zeng, Jing Yang, Lei Li, Xi Kuang, Tao Zhang
BACKGROUND: Hepatitis B virus (HBV) infection correlated with the development of cirrhosis, liver failure and hepatocellular carcinoma (HCC), poses a huge health burden on the global community. However, the pathogenesis of chronic hepatitis B (CHB) remains unclear. Apolipoprotein A1 (ApoA1) mainly secreted by hepatocytes, represents the major protein component of high-density lipoprotein. ApoA1 secretion may be disrupted by HBV infection. In this study, we mainly investigated the molecular mechanism of ApoA1 down regulated by HBV for revealing the pathogenesis of CHB...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/26077337/genetic-evidence-for-common-pathways-in-human-age-related-diseases
#9
Simon C Johnson, Xiao Dong, Jan Vijg, Yousin Suh
Aging is the single largest risk factor for chronic disease. Studies in model organisms have identified conserved pathways that modulate aging rate and the onset and progression of multiple age-related diseases, suggesting that common pathways of aging may influence age-related diseases in humans as well. To determine whether there is genetic evidence supporting the notion of common pathways underlying age-related diseases, we analyzed the genes and pathways found to be associated with five major categories of age-related disease using a total of 410 genomewide association studies (GWAS)...
October 2015: Aging Cell
https://www.readbyqxmd.com/read/25760982/protein-identification-from-dried-nipple-aspirate-fluid-on-guthrie-cards-using-mass-spectrometry
#10
Lucas Delmonico, Vivian Rabello Areias, Rodrigo César Pinto, Cintia Da Silva Matos, Marco Felipe Franco Rosa, Carolina Maria De Azevedo, Gilda Alves
Nipple aspirate fluid (NAF) requires investigation as a potential source of biomarkers for early diagnosis or risk assessment in breast cancer and other breast disorders. The present study demonstrated that proteins were easily extracted from dried NAF spots on Guthrie cards and were suitable for mass spectrometry analysis. NAF was obtained from 80 women, collected on Guthrie cards, between 2007 and 2010. The NAF-proteins were extracted from the card by incubating the card in water. These proteins were then quantified and separated using one-dimensional, 12% SDS-PAGE, gel electrophoresis and on high-resolution gradient gels at different concentrations (4-12, 8-16 and 4-20%)...
July 2015: Molecular Medicine Reports
https://www.readbyqxmd.com/read/25719283/the-role-of-apolipoprotein-a-in-pathogenesis-and-clinical-course-of-deep-venous-thrombosis
#11
COMPARATIVE STUDY
Marek Chrapko, Adam Skwarzyński, Wacław Karakuła, Tomasz Zubilewicz
UNLABELLED: Deep venous thrombosis is widespread disease, which complications, like: pulmonary embolism and postphlebitis syndrome areimportant social problem. There are many well-known and accurately described risk factors, though in many cases etiology remains unexplained. Further research into causes of deep venous thrombosis seem to be fully justified. The aim of the study was the evaluation of the influence of apolipoprotein (a) serum level in patients with deep venous thrombosis and the changes of its concentration during the treatment...
November 2014: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/25406726/interactions-between-lipid-free-apolipoprotein-ai-and-a-lipopeptide-incorporating-the-rgds-cell-adhesion-motif
#12
V Castelletto, I W Hamley, M Reza, J Ruokolainen
The interaction of a designed bioactive lipopeptide C16-GGGRGDS, comprising a hexadecyl lipid chain attached to a functional heptapeptide, with the lipid-free apoliprotein, Apo-AI, is examined. This apolipoprotein is a major component of high density lipoprotein and it is involved in lipid metabolism and may serve as a biomarker for cardiovascular disease and Alzheimers' disease. We find via isothermal titration calorimetry that binding between the lipopeptide and Apo-AI occurs up to a saturation condition, just above equimolar for a 10...
January 7, 2015: Nanoscale
https://www.readbyqxmd.com/read/25115832/investigation-into-the-effect-of-hepatitis-b-virus-on-apoliprotein-a1-expression-and-its-mechanism
#13
Weichao Jiang, Lei Zheng, Qianqian Yang, Zhouying Huang, Xiaobei Wang
BACKGROUND: Hepatitis B virus (HBV) infection poses a serious threat to human health, with China being one of the highly affected countries. However, the pathogenesis of chronic hepatitis B (CHB) is still unclear. Apolipoprotein A1 (ApoA1) which represents the major protein component of high-density lipoprotein is normally secreted by hepatocytes. When hepatocytes are infected with HBV may lead to the disruption of ApoA1 secretion. In this study, we investigated the effect of HBV on ApoA1 expression and preliminarily explored its molecular mechanism of regulation for revealing the pathogenesis of CHB...
2014: Lipids in Health and Disease
https://www.readbyqxmd.com/read/25006659/association-of-carotid-intima-media-thickness-with-leptin-and-apoliprotein-b-apoliprotein-a-i-ratio-reveals-imminent-predictors-of-subclinical-atherosclerosis-in-psoriasis-patients
#14
Kumari Asha, Suman B Sharma, Archana Singal, Amitesh Aggarwal
Psoriasis patients are often susceptible to cardiovascular diseases (CVD), including atherosclerosis. Traditional markers (biochemical and inflammatory) and diagnostic tools could detect occlusive but not subclinical atherosclerosis. Carotid intima-media thickness (CIMT), has recently been recognised as a non invasive diagnostic tool for identification of premature atherosclerosis. Therefore we evaluated 80 psoriasis patients and 80 age sex matched healthy controls for serum leptin levels and apolipoprotein B/apolipoprotein A-I ratio (apoB/apoA-I ratio) in relation with CIMT of carotid artery...
2014: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/24676620/lipoprotein-glomerulopathy-a-case-report-of-a-rare-disease-in-a-brazilian-child
#15
Karla Lais Pêgas, Roberta Rohde, Clotilde Druck Garcia, Viviane de Barros Bittencourt, Elizete Keitel, José Antonio Tesser Poloni, Eduardo Cambruzzi
Lipoprotein glomerulopathy (LPG) is a rare autosomal recessive glomerulopathy associated with the deposition of lipoprotein thrombi in the capillary lumina due to apoE gene mutations. Abnormal plasma lipoprotein profile and marked increase in serum apoliprotein E (apoE) are characteristic clinical data. The compromised patients can present nephrotic syndrome, hematuria, and progressive renal failure. Herein, the authors present the first described case of LPG in a Brazilian male patient, 11 years, who presented with a steroid-resistant nephrotic syndrome...
January 2014: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/24651399/self-assembling-peptides-form-nanodiscs-that-stabilize-membrane-proteins
#16
Søren Roi Midtgaard, Martin Cramer Pedersen, Jacob Judas Kain Kirkensgaard, Kasper Kildegaard Sørensen, Kell Mortensen, Knud J Jensen, Lise Arleth
New methods to handle membrane bound proteins, e.g. G-protein coupled receptors (GPCRs), are highly desirable. Recently, apoliprotein A1 (ApoA1) based lipoprotein particles have emerged as a new platform for studying membrane proteins, and it has been shown that they can self-assemble in combination with phospholipids to form discoidal shaped particles that can stabilize membrane proteins. In the present study, we have investigated an ApoA1 mimetic peptide with respect to its solution structure when in complex with phospholipids...
February 7, 2014: Soft Matter
https://www.readbyqxmd.com/read/24530308/apoliprotein-e-genotype-is-associated-with-apoliprotein-b-plasma-levels-but-not-with-coronary-calcium-score-in-very-elderly-individuals-in-primary-care-setting
#17
Adriane D Henriques, Audrey C Tonet-Furioso, Wilcelly Machado-Silva, Wladimir M Freitas, Luiz A Quaglia, Simone N Santos, Cláudio Córdova, Andrei C Sposito, Otávio T Nóbrega
BACKGROUND: Epidemiological surveys indicate the influence of polymorphisms of apolipoprotein (apo) E on plasma lipids and triglyceride-rich lipoprotein levels, with impact on atherosclerotic phenotypes. AIM: We studied the association of classic genotypes of the apoE gene with clinical and biochemical risk factors for atherosclerosis in a segment of the very-old Brazilian individuals, with emphasis on the lipemic profile. METHODS: We performed cross-sectional analyses of clinical and laboratory assessments, including cardiac computed tomography, across ε2, ε3 and ε4 carriers of the apoE gene with a convenience sample of 208 participants eligible for prevention against cardiovascular events...
April 15, 2014: Gene
https://www.readbyqxmd.com/read/23870169/integration-deficient-lentivectors-an-effective-strategy-to-purify-and-differentiate-human-embryonic-stem-cell-derived-hepatic-progenitors
#18
Guanghua Yang, Karim Si-Tayeb, Sébastien Corbineau, Rémi Vernet, Régis Gayon, Noushin Dianat, Clémence Martinet, Denis Clay, Sylvie Goulinet-Mainot, Gérard Tachdjian, Gérard Tachdjian, Deborah Burks, Ludovic Vallier, Pascale Bouillé, Anne Dubart-Kupperschmitt, Anne Weber
BACKGROUND: Human pluripotent stem cells (hPSCs) hold great promise for applications in regenerative medicine. However, the safety of cell therapy using differentiated hPSC derivatives must be improved through methods that will permit the transplantation of homogenous populations of a specific cell type. To date, purification of progenitors and mature cells generated from either embryonic or induced pluripotent stem cells remains challenging with use of conventional methods. RESULTS: We used lentivectors encoding green fluorescent protein (GFP) driven by the liver-specific apoliprotein A-II (APOA-II) promoter to purify human hepatic progenitors...
July 19, 2013: BMC Biology
https://www.readbyqxmd.com/read/23815016/-amyloid-polyneuropathies-biochemical-and-genetic-aspects
#19
REVIEW
Marc Delpech, Sophie Valleix
Familial amyloid polyneuropathies (FAP) are among the most frequent hereditary amyloidoses. These are serious, most often fatal diseases with autosomal dominant inheritance. FAP can be caused by mutations in four genes, namely those encoding transthyretin, Al-apoliprotein, gelsolin, and beta-2 microglobulin. Transthyretin is a tetramer composed of four identical subunits linked by non covalent bonds and bearing binding sites for thyroxine (T4) and retinol-binding protein (RBP). More than 120 transthyretin gene sequence variations have been characterized, of which only 80% seem to be pathogenic...
October 2012: Bulletin de L'Académie Nationale de Médecine
https://www.readbyqxmd.com/read/23775611/association-between-serum-cholesterol-and-eating-behaviours-during-early-childhood-a-cross-sectional-study
#20
MULTICENTER STUDY
Navindra Persaud, Jonathon L Maguire, Gerald Lebovic, Sarah Carsley, Marina Khovratovich, Janis A Randall Simpson, Brian W McCrindle, Patricia C Parkin, Catherine Birken
BACKGROUND: Modifiable behaviours during early childhood may provide opportunities to prevent disease processes before adverse outcomes occur. Our objective was to determine whether young children's eating behaviours were associated with increased risk of cardiovascular disease in later life. METHODS: In this cross-sectional study involving children aged 3-5 years recruited from 7 primary care practices in Toronto, Ontario, we assessed the relation between eating behaviours as assessed by the NutriSTEP (Nutritional Screening Tool for Every Preschooler) questionnaire (completed by parents) and serum levels of non-high-density lipoprotein (HDL) cholesterol, a surrogate marker of cardiovascular risk...
August 6, 2013: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
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