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https://www.readbyqxmd.com/read/29031214/land-use-regression-models-for-the-oxidative-potential-of-fine-particles-pm2-5-in-five-european-areas
#1
John Gulliver, David Morley, Chrissi Dunster, Adrienne McCrea, Erik van Nunen, Ming-Yi Tsai, Nicoltae Probst-Hensch, Marloes Eeftens, Medea Imboden, Regina Ducret-Stich, Alessio Naccarati, Claudia Galassi, Andrea Ranzi, Mark Nieuwenhuijsen, Ariadna Curto, David Donaire-Gonzalez, Marta Cirach, Roel Vermeulen, Paolo Vineis, Gerard Hoek, Frank J Kelly
Oxidative potential (OP) of particulate matter (PM) is proposed as a biologically-relevant exposure metric for studies of air pollution and health. We aimed to evaluate the spatial variability of the OP of measured PM2.5 using ascorbate (AA) and (reduced) glutathione (GSH), and develop land use regression (LUR) models to explain this spatial variability. We estimated annual average values (m(-3)) of OP(AA) and OP(GSH) for five areas (Basel, CH; Catalonia, ES; London-Oxford, UK (no OP(GSH)); the Netherlands; and Turin, IT) using PM2...
October 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/29031213/impairment-of-heart-rhythm-complexity-in-patients-with-drug-resistant-epilepsy-an-assessment-with-multiscale-entropy-analysis
#2
Hongyun Liu, Zhao Yang, Fangang Meng, Yuguang Guan, Yanshan Ma, Shuli Liang, Jiuluan Lin, Longsheng Pan, Mingming Zhao, Wei Qu, Hongwei Hao, Guoming Luan, Jianguo Zhang, Luming Li
OBJECTIVE: Epilepsy and seizures can have dramatic effects on the cardiac function. The aim of this study was to investigate the heart rhythm complexity in patients with drug-resistant epilepsy (DRE). METHODS: Ambulatory 24-h electrocardiograms (ECG) from 70 DRE patients and 50 healthy control subjects were analyzed using conventional heart rate variability (HRV) and multiscale entropy (MSE) methods The variation of complexity indices (CI), which was calculated from MSE profile, was determined...
October 5, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29031206/inhibitory-effect-of-triperygium-wilfordii-polyglucoside-on-dipeptidyl-peptidase-i-in-vivo-and-in-vitro
#3
Jingjing Wang, Yi Chu, Xiaoying Zhou
BACKGROUD: Dipeptidyl peptidase I (DPPI), a lysosomal cysteine protease is derived from granule immune cells including mast cell, neutrophils, and toxicity T cells. DPPI can activate serine proteases by removal of dipeptides from N-termini of the pro-proteases, resulting in granule immune cells activation which involved in physiological or pathological responses. Triperygium Wilfordii Polyglucoside (TWP) is one of the traditional Chinese medicines, and commonly used in rheumatoid arthritis (RA) treatment...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031069/synthesis-and-biological-evaluation-of-a-platinum-ii-c-rgdyk-conjugate-for-integrin-targeted-photodynamic-therapy
#4
T Chatzisideri, S Thysiadis, S Katsamakas, P Dalezis, I Sigala, T Lazarides, E Nikolakaki, D Trafalis, O A Gederaas, M Lindgren, V Sarli
A cancer-targeting conjugate 4 of a cyclometalated [N,C,N-Pt(II)] complex bearing a NˆCˆN 1,3-di(2-pyridyl)-benzene with c(RGDyK) peptide as guiding molecule was designed and synthesized for real-time drug delivery monitoring in cancer cells and photodynamic therapy (PDT). This conjugate demonstrates a mild cytostatic effect to six cancer cell lines expressing integrins at different extent, while possessing promising features for PDT. Conjugate 4 demonstrated rapid cell uptake by receptor-mediated endocytosis and efficient generation of (1)O2 upon irradiation...
September 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031018/strategies-to-define-performance-specifications-in-laboratory-medicine-3-years-on-from-the-milan-strategic-conference
#5
Mauro Panteghini, Ferruccio Ceriotti, Graham Jones, Wytze Oosterhuis, Mario Plebani, Sverre Sandberg
Measurements in clinical laboratories produce results needed in the diagnosis and monitoring of patients. These results are always characterized by some uncertainty. What quality is needed and what measurement errors can be tolerated without jeopardizing patient safety should therefore be defined and specified for each analyte having clinical use. When these specifications are defined, the total examination process will be "fit for purpose" and the laboratory professionals should then set up rules to control the measuring systems to ensure they perform within specifications...
October 14, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29029375/treatment-and-disease-management-of-multiple-sclerosis-patients-a-review-for-nurse-practitioners
#6
Cortnee Roman, Kara Menning
BACKGROUND AND PURPOSE: This review discusses the role of the nurse practitioner (NP) in evaluating the clinical effects, potential side effects, and monitoring requirements for treatment options in multiple sclerosis (MS) and provides guidance on how to help patients understand these issues. METHODS: A literature search was conducted on PubMed to identify publications on monitoring and disease management of MS patients. Additional resources included drug information web sites and package inserts...
October 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29029365/eighteen-month-lamivudine-prophylaxis-on-preventing-occult-hepatitis-b-virus-hbv-infection-reactivation-in-patients-with-hematologic-malignancies-receiving-immunosuppression-therapy
#7
Aldo Marrone, Nicolina Capoluongo, Chiara D'Amore, Mariantonietta Pisaturo, Mariarosaria Esposito, Salvatore Guastafierro, Isabella Siniscalchi, Margherita Macera, Adriana Boemio, Lorenzo Onorato, Luca Rinaldi, Carmine Minichini, Luigi Elio Adinolfi, Evangelista Sagnelli, Lucia Mastrullo, Nicola Coppola
This study evaluated the long-term efficacy and safety of an 18-month lamivudine prophylaxis in 68 HBsAg-negative/anti-HBc-positive patients with onco-hematological disease. All 68 consecutive HBsAg-negative/anti-HBc-positive patients with an onco-hematological disease and naïve for chemotherapy observed from April 2008 to December 2012 at two Hematology Units in Naples were treated with lamivudine for 18 months after stopping chemotherapy and monitored for HBsAg at months 1 and 3 during chemotherapy and then every three months after its discontinuation...
October 13, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29029325/guidelines-for-the-use-of-electrophysiological-monitoring-for-surgery-of-the-human-spinal-column-and-spinal-cord
#8
Mark N Hadley, Christopher D Shank, Curtis J Rozzelle, Beverly C Walters
No abstract text is available yet for this article.
September 27, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29029317/the-critical-role-of-supply-chains-in-preventing-human-immunodeficiency-virus-drug-resistance-in-low-and-middle-income-settings
#9
Thomas Minior, Meaghan Douglas, Dianna Edgil, Meena Srivastava, John Crowley, Jacqueline Firth, Ilana Lapidos-Salaiz, Jason Williams, Lana Lee
The functioning of the supply chain may be a driving factor behind the development of human immunodeficiency virus (HIV) drug resistance (HIVDR) in many low- and middle-income countries (LMICs). Additionally, the effectiveness of supply chains will likely impact the scale-up of both viral-load monitoring and HIVDR testing. This article describes the complexities of global supply chains relevant for LMICs and presents early data on stock-outs and drug substitutions in several countries supported by the US President's Emergency Plan for AIDS Relief...
October 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029307/droplet-digital-pcr-diagnosis-of-human-schistosomiasis-parasite-cell-free-dna-detection-in-diverse-clinical-samples
#10
Kosala G Weerakoon, Catherine A Gordon, Gail M Williams, Pengfei Cai, Geoffrey N Gobert, Remigio M Olveda, Allen G Ross, David U Olveda, Donald P McManus
Background: Schistosomiasis japonica remains a major public health and socio-economic concern in Southeast-Asia. Sensitive and accurate diagnostics can play a pivotal role in achieving disease elimination goals. Methods: We previously reported a novel droplet digital-PCR (ddPCR) assay targeting the mitochondrial gene nad1 to diagnose schistosomiasis japonica. The tool identified both pre-patent and patent infections using Schistosoma japonicum DNA isolated from serum, urine, salivary glands and faeces in a murine model...
September 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029300/flight-activity-and-field-infestation-relationships-for-coffee-berry-borer-in-commercial-coffee-plantations-in-kona-and-kau-districts-hawaii
#11
Luis F Aristizábal, Suzanne Shriner, Robert Hollingsworth, Steven Arthurs
The coffee berry borer (CBB), Hypothenemus hampei Ferrari (Coleoptera: Curculionidae: Scolytinae) is a recent invader to Hawaii. To date, limited information regarding the seasonal phenology of this pest on the islands limits the implementation of integrated control strategies. As part of a coffee farmer training program, we monitored CBB flight activity in 15 coffee plantations (Kona and Kau Districts) over 10 mo with methanol-ethanol (3:1 ratio) baited traps. Concurrently, we quantified CBB infestation and penetration rates inside developing coffee berries through the end of harvest...
September 27, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29029290/nmda-receptor-mediated-ca2-influx-in-the-absence-of-mg2-block-disrupts-rest-activity-rhythms-in-drosophila
#12
Qian Song, Ge Feng, Jiaxing Zhang, Xuechun Xia, Min Ji, Lei Lv, Yong Ping
Introduction: The correlated activation of pre- and postsynaptic neurons is essential for the NMDA receptor-mediated Ca2+ influx by removing Mg2+ from block site and NMDA receptors have been implicated in phase resetting of circadian clocks. So we assessed rest:activity rhythms in Mg2+ block defective animals. Methods: Using Drosophila locomotor monitoring system, we checked circadian rest:activity rhythms of different mutants under constant darkness (DD) and light:dark (LD) conditions...
October 3, 2017: Sleep
https://www.readbyqxmd.com/read/29029284/the-influence-of-co2-on-genioglossus-muscle-after-discharge-following-arousal-from-sleep-hypocapnia-and-genioglossus-muscle-after-discharge
#13
Jennifer M Cori, Peter D Rochford, Fergal J O'Donoghue, John Trinder, Amy S Jordan
Objectives: Ventilatory after-discharge (sustained elevation of ventilation following stimulus removal), occurs during sleep but not when hypocapnia is present. Genioglossus after-discharge also occurs during sleep, but CO2 effects have not been assessed. The relevance is that post-arousal after-discharge may protect against upper airway collapse. This study aimed to determine whether arousal elicits genioglossus after-discharge that persists into sleep, and whether it is influenced by CO2...
October 6, 2017: Sleep
https://www.readbyqxmd.com/read/29029273/the-citizen-science-project-mueckenatlas-helps-monitor-the-distribution-and-spread-of-invasive-mosquito-species-in-germany
#14
Doreen Walther, Helge Kampen
The citizen science project 'Mueckenatlas' (mosquito atlas) was implemented in early 2012 to improve mosquito surveillance in Germany. Citizens are asked to support the spatiotemporal mapping of culicids by submitting mosquito specimens collected in their private surroundings. The Mueckenatlas has developed into an efficient tool for data collection with close to 30,000 mosquitoes submitted by the end of 2015. While the vast majority of submissions included native mosquito species, a small percentage represented invasive species...
September 23, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29029272/bsr-and-bhpr-guideline-for-the-prescription-and-monitoring-of-non-biologic-disease-modifying-anti-rheumatic-drugs
#15
Jo Ledingham, Nicola Gullick, Katherine Irving, Rachel Gorodkin, Melissa Aris, Jean Burke, Patrick Gordon, Dimitrios Christidis, Sarah Galloway, Eranga Hayes, Andrew Jeffries, Scott Mercer, Janice Mooney, Sander van Leuven, James Galloway
No abstract text is available yet for this article.
September 28, 2017: Rheumatology
https://www.readbyqxmd.com/read/29029259/first-experimental-assessment-of-protein-intrinsic-disorder-involvement-in-an-rna-virus-natural-adaptive-process
#16
Justine Charon, Amandine Barra, Jocelyne Walter, Pauline Millot, Eugénie Hébrard, Benoît Moury, Thierry Michon
Intrinsic disorder (ID) in proteins is defined as a lack of stable structure in physiological conditions. Intrinsically disordered regions (IDRs) are highly abundant in some RNA virus proteomes. Low topological constraints exerted on IDRs are expected to buffer the effect of numerous deleterious mutations and could be related to the remarkable adaptive potential of RNA viruses to overcome resistance of their host. To experimentally test this hypothesis in a natural pathosystem, a set of four variants of Potato virus Y (PVY; Potyvirus genus) containing various ID degrees in the Viral genome-linked (VPg) protein, a key determinant of potyvirus adaptation, was designed...
September 18, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29029209/genetic-evidence-for-the-introduction-of-rhagoletis-pomonella-diptera-tephritidae-into-the-northwestern-united-states
#17
Sheina B Sim, Meredith M Doellman, Glen R Hood, Wee L Yee, Thomas H Q Powell, Dietmar Schwarz, Robert B Goughnour, Scott P Egan, Gilbert St Jean, James J Smith, Tracy E Arcella, Jason D K Dzurisin, Jeffrey L Feder
The apple maggot fly, Rhagoletis pomonella Walsh (Diptera: Tephritidae), is a serious quarantine pest in the apple-growing regions of central Washington and Oregon. The fly is believed to have been introduced into the Pacific Northwest via the transport of larval-infested apples near Portland, Oregon, within the last 40 yr. However, R. pomonella also attacks native black hawthorn, Crataegus douglasii Lindley (Rosales: Rosaceae), and introduced ornamental hawthorn, Crataegus monogyna Jacquin, in the region. It is, therefore, possible that R...
October 6, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29029178/expansion-of-viral-load-testing-and-the-potential-impact-on-human-immunodeficiency-virus-drug-resistance
#18
Helen M Chun, Yaa F Obeng-Aduasare, Laura N Broyles, Dennis Ellenberger
Increasing the volume, strengthening the quality, and proactively using data of human immunodeficiency virus (HIV) load testing are pivotal to limiting the threat of HIV drug resistance (HIVDR) accumulation,and allow for optimal case-based HIVDR surveillance. Triangulation of viral load (VL) and HIVDR testing data could be pursued to answer key questions and translate data and results for program and public policy. Identification of virologic failure and early management mitigates the greater risk of HIVDR...
October 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029134/the-natural-history-and-surgical-outcome-of-patients-with-scimitar-syndrome-a-multi-centre-european-study
#19
Vladimiro L Vida, Alvise Guariento, Ornella Milanesi, Dario Gregori, Giovanni Stellin
Aims: Treatment decisions in patients with scimitar syndrome (SS) are often challenging, especially in patients with isolated SS who are often asymptomatic and who might be diagnosed accidentally. We queried a large multi-institutional registry of SS patients to evaluate the natural history of this condition and to determine the efficacy of surgical treatment in terms of survival and clinical status. Methods and results: We collected data on 485 SS patients from 51 institutions; 279 (57%) patients were treated surgically (STPs) and 206 (43%) were clinically monitored (CMPs)...
October 3, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29029130/alternative-sample-types-for-hiv-1-antiretroviral-drug-resistance-testing
#20
Dolly Singh, Adit Dhummakupt, Lilly Siems, Deborah Persaud
Monitoring human immunodeficiency virus type 1 (HIV-1) drug resistance is critical for assessing ART effectiveness and treatment outcomes for HIV-1-infected individuals, including children, worldwide. Traditionally, testing for HIV-1 drug resistance has primarily been performed on plasma samples, and with commercially available, clinically validated assays that are costly and difficult to access. While plasma is the preferred sample for HIV-1 drug resistance genotyping, plasma analysis requires sophisticated laboratory equipment, personnel, space, and stringent storage conditions for maintenance of sample integrity and transport...
October 6, 2017: Journal of Infectious Diseases
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