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Laser evoked potentials Habituation

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https://www.readbyqxmd.com/read/27461877/expectation-to-feel-more-pain-disrupts-the-habituation-of-laser-pain-rating-and-laser-evoked-potential-amplitudes
#1
Costanza Pazzaglia, Elisa Testani, Rocco Giordano, Luca Padua, Massimiliano Valeriani
Increased pain perception due to the expectation to feel more pain is called nocebo effect. The present study aimed at investigating whether: (1) the mere expectation to feel more pain after the administration of an inert drug can affect the laser-pain rating and the laser-evoked potential (LEP) amplitude, and (2) the learning potentiates the nocebo effect. Eighteen healthy volunteers were told that an inert cream, applied on the right hand, would increase the laser pain and LEP amplitude to right hand stimulation...
October 1, 2016: Neuroscience
https://www.readbyqxmd.com/read/27231940/effects-of-onabotulintoxina-on-habituation-of-laser-evoked-responses-in-chronic-migraine
#2
Marina de Tommaso, Marianna Delussi, Katia Ricci, Anna Montemurno, Irene Carbone, Eleonora Vecchio
Onabotulintoxin A (BontA) is an efficacious preventive treatment for chronic migraine, though the specific mechanism of action is still under discussion. The study aims: (1) To evaluate pain processing modifications in chronic migraine patients (CM) under single BontA administration in pericranial muscles, by means of CO² Laser Evoked Potentials (LEPs) obtained by the stimulation of the skin over the right frontal and trapezius injection sites and hand dorsum, in a double blind placebo controlled crossover design...
2016: Toxins
https://www.readbyqxmd.com/read/27208831/effects-of-left-primary-motor-and-dorsolateral-prefrontal-cortex-transcranial-direct-current-stimulation-on-laser-evoked-potentials-in-migraine-patients-and-normal-subjects
#3
Eleonora Vecchio, Katia Ricci, Anna Montemurno, Marianna Delussi, Sara Invitto, Marina de Tommaso
Migraine is characterized by an altered cortical excitability. Because transcranial direct current stimulation (tDCS) can change brain activity noninvasively, it is possible to hypothesize its efficacy in modulating pain in migraine. In this study, we compared the effects of tDCS of the left primary motor cortex (M1) and left dorsolateral prefrontal cortex (DLPFC) both on subjective pain and on evoked responses induced by laser stimulation (LEPs). Thirty-two patients and sixteen controls were randomized to receive sham stimulation and real tDCS with the anode centered over M1 or DLPFC...
July 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/26892176/focal-mechanical-vibration-does-not-change-laser-pain-perception-and-laser-evoked-potentials-a-pilot-study
#4
Costanza Pazzaglia, Filippo Camerota, Claudia Celletti, Ileana Minciotti, Elisa Testani, Luca Padua, Massimiliano Valeriani
BACKGROUND: Nonpainful tactile and electrical stimulation of the large myelinated fibers reduces spontaneous pain and the amplitude of laser-evoked potentials (LEPs), which represent the most reliable technique to assess the nociceptive pathway function. Focal mechanical vibration stimulates the Aβ afferents selectively; thus, it is conceivable its action on nociceptive pathways. AIM: The aim of this study was to investigate the effect of vibratory stimuli, activating either both muscle and skin receptors or cutaneous afferents only on the LEPs and subjective laser-pain rating...
February 19, 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/26602971/peripheral-sensitization-reduces-laser-evoked-potential-habituation
#5
P Hüllemann, R Watfeh, Y-Q Shao, A Nerdal, A Binder, R Baron
OBJECTIVE: Laser-evoked potential (LEP) habituation was investigated under the influence of capsaicin-induced peripheral and central sensitization. MATERIAL AND METHODS: Fifteen subjects received 100 repetitive painful laser stimuli at the right hand dorsum at primary (application area; condition I) and secondary areas (beyond application area; condition II) in two different sessions after applying capsaicin topically. Conditions I and II were compared to a control condition without capsaicin application...
December 2015: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/26232104/laser-evoked-potential-habituation-and-central-sensitization-symptoms-in-childhood-migraine
#6
Marina de Tommaso, Vittorio Sciruicchio, Katia Ricci, Anna Montemurno, Francesco Gentile, Eleonora Vecchio, Maria Grazia Foschino Barbaro, Michele Simeoni, Marvita Goffredo, Paolo Livrea
OBJECTIVES: Few studies have addressed central sensitization symptoms and pain processing in childhood migraine. Our aims were to examine pain sensitivity and responses, including habituation, evoked by CO2 laser stimuli (laser-evoked potentials (LEPs)) in a cohort of children with migraine compared to non-migraine controls and to determine the correlation between LEP features and signs of central sensitization. METHODS: Thirty-five patients 8-15 years of age with migraines without aura were evaluated during the inter-critical phase and were compared to 17 controls...
April 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/26076052/central-habituation-and-distraction-alter-c-fibre-mediated-laser-evoked-potential-amplitudes
#7
P Hüllemann, Y Q Shao, G Manthey, A Binder, R Baron
BACKGROUND: Recent studies applied laser-evoked potentials (LEP) for the analysis of small nerve fibre function and focused on the detection of stable C-fibre-mediated potentials (C-LEPs); high technical requirements were needed. The diagnostic significance is still controversially discussed. So far, only few studies focused on the susceptibility of C-LEPs to distraction and other influences. We hypothesized that C-LEPs are altered by habituation processes and distraction. METHODS: Twelve subjects were tested with a C-fibre laser set-up (neodymium:yttrium-aluminium-perovskite laser with a 10-mm beam diameter and 10-ms stimulus time) at the left perioral area...
March 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/25851512/effect-of-sleep-deprivation-on-the-electrophysiological-signature-of-habituation-to-noxious-laser-stimuli
#8
S Schuh-Hofer, U Baumgärtner, R-D Treede
BACKGROUND: Sleep deprivation induces hyperalgesia. However, this pro-nociceptive effect is not reflected at the electrophysiological level, since sleep restricted subjects show amplitude reduction of Laser-evoked Potentials (LEP). We aimed to explore the contribution of habituation to this paradoxical LEP amplitude decline. METHODS: We compared LEP's of 12 healthy students (23.2 ± 1.1 years) after habitual sleep (HS) and a night of total sleep deprivation (TSD)...
September 2015: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/25579466/the-effect-of-sleep-restriction-on-laser-evoked-potentials-thermal-sensory-and-pain-thresholds-and-suprathreshold-pain-in-healthy-subjects
#9
RANDOMIZED CONTROLLED TRIAL
Siv Steinsmo Ødegård, Petter Moe Omland, Kristian Bernhard Nilsen, Marit Stjern, Gøril Bruvik Gravdahl, Trond Sand
OBJECTIVE: Sleep restriction seems to change our experience of pain and reduce laser evoked potential (LEP) amplitudes. However, although LEP-habituation abnormalities have been described in painful conditions with comorbid sleep impairment, no study has previously measured the effect of sleep restriction on LEP-habituation, pain thresholds, and suprathreshold pain. METHOD: Sixteen males and seventeen females (aged 18-31years) were randomly assigned to either two nights of delayed bedtime and four hours sleep (partial sleep deprivation) or nine hours sleep...
October 2015: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/24366650/update-on-laser-evoked-potential-findings-in-fibromyalgia-patients-in-light-of-clinical-and-skin-biopsy-features
#10
Marina de Tommaso, Maria Nolano, Florenzo Iannone, Eleonora Vecchio, Katia Ricci, Marta Lorenzo, Marianna Delussi, Francesco Girolamo, Vito Lavolpe, Vincenzo Provitera, Annamaria Stancanelli, Giovanni Lapadula, Paolo Livrea
In fibromyalgia (FM), reduced habituation of laser-evoked potentials (LEPs) suggests a dysfunction of pain processing at a central level. In this study, we aimed to further examine the nociceptive pathways at the peripheral to the central level in a large group of FM patients by means of LEPs and skin biopsy, in light of healthy controls findings and main clinical features. One hundred and ninety-nine FM patients and 109 age- and sex-matched controls were submitted to LEPs by the dorsum of the right hand and the skin over the right chest and knee tender point stimulation...
March 2014: Journal of Neurology
https://www.readbyqxmd.com/read/23977382/theta-burst-stimulation-applied-over-primary-motor-and-somatosensory-cortices-produces-analgesia-unrelated-to-the-changes-in-nociceptive-event-related-potentials
#11
Diana M E Torta, Valéry Legrain, Maxime Algoet, Etienne Olivier, Julie Duque, André Mouraux
Continuous theta burst stimulation (cTBS) applied over the primary motor cortex (M1) can alleviate pain although the neural basis of this effect remains largely unknown. Besides, the primary somatosensory cortex (S1) is thought to play a pivotal role in the sensori-discriminative aspects of pain perception but the analgesic effect of cTBS applied over S1 remains controversial. To investigate cTBS-induced analgesia we characterized, in two separate experiments, the effect of cTBS applied either over M1 or S1 on the event-related brain potentials (ERPs) and perception elicited by nociceptive (CO2 laser stimulation) and non-nociceptive (transcutaneous electrical stimulation) somatosensory stimuli...
2013: PloS One
https://www.readbyqxmd.com/read/23716481/repetitive-ipsilateral-painful-a-delta-fibre-stimuli-induce-bilateral-lep-amplitude-habituation
#12
P Hüllemann, F Mahn, Y-Q Shao, R Watfeh, G Wasner, A Binder, R Baron
BACKGROUND: In the scientific approach to central processing of pain, the habituation phenomenon has been frequently described. Recent studies mentioned electrophysiological habituation during the recording of laser-evoked potentials (LEP). In this study we intended to test whether habituation can be reproducibly induced by repetitive painful laser stimuli and simultaneously measured with LEP. Inspired by findings from previous imaging studies that showed bilateral activation of the operculo-insular cortices, we hypothesized that repetitive painful laser stimuli applied to one hand lead to bihemispheral LEP amplitude habituation...
November 2013: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/23566208/topiramate-modulates-habituation-in-migraine-evidences-from-nociceptive-responses-elicited-by-laser-evoked-potentials
#13
Laura Di Clemente, Francesca Puledda, Antonella Biasiotta, Alessandro Viganò, Edoardo Vicenzini, Andrea Truini, Giorgio Cruccu, Vittorio Di Piero
BACKGROUND: Lack of habituation during repetitive stimulation is the most consistent interictal abnormality of cortical information processing observed in migraine. Preventive migraine treatments might act by stabilizing cortical excitability level and thus the habituation to external stimuli. METHODS: We examined the effects of preventive treatment with topiramate on migraineur's habituation to nociceptive stimulation. Scalp potentials were evoked by Nd-YAP Laser stimulation of the hand dorsum and supraorbital region in 13 patients with migraine without aura (MO) and 15 healthy volunteers (HV)...
2013: Journal of Headache and Pain
https://www.readbyqxmd.com/read/23040698/contact-heat-and-cold-mechanical-electrical-and-chemical-stimuli-to-elicit-small-fiber-evoked-potentials-merits-and-limitations-for-basic-science-and-clinical-use
#14
REVIEW
U Baumgärtner, W Greffrath, R-D Treede
Laser-evoked potentials are the most extensively validated method to objectively assess nociceptive pathway function in humans. Here, we review merits and shortcomings of alternative techniques using different principles of stimulus generation to stimulate Aδ- or C-fibers. Fast ramp contact heat stimuli yield reproducible responses; however, stimulus location needs to be changed to reduce peripheral habituation, and the limited steepness of temperature ramps may result in response jitter and absence of averaged responses even in some healthy subjects...
October 2012: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/22512411/habituation-to-pain-in-medication-overuse-headache-a-co2-laser-evoked-potential-study
#15
Diana Ferraro, Catello Vollono, Roberto Miliucci, Daniela Virdis, Liala De Armas, Costanza Pazzaglia, Domenica Le Pera, Samuela Tarantino, Martina Balestri, Girolamo Di Trapani, Massimiliano Valeriani
OBJECTIVE: Our aim was to investigate CO(2) laser-evoked potential (LEP) habituation to experimental pain in a group of patients affected by medication-overuse headache, with a history of episodic migraine becoming chronic, before and after treatment, consisting in acute medication withdrawal and a preventive treatment cycle. BACKGROUND: One of the main features of LEPs in migraineurs is a lower habituation to repetitive noxious stimuli during the interictal phase...
May 2012: Headache
https://www.readbyqxmd.com/read/22349498/dishabituation-of-laser-evoked-eeg-responses-dissecting-the-effect-of-certain-and-uncertain-changes-in-stimulus-spatial-location
#16
D M Torta, M Liang, E Valentini, A Mouraux, G D Iannetti
The repetition of nociceptive stimuli of identical modality, intensity and location at short (1 s) and constant inter-stimulus interval (ISI) determines a strong habituation of the corresponding electroencephalographic (EEG) responses. To understand what determines this response habituation, we (1) examined the effect of introducing a selective change in the spatial location of the repeated stimulus (i.e., without altering its modality, intensity and timing), and (2) dissected the relative contribution of bottom-up, stimulus-driven spatial changes and top-down, cognitive expectations of such a change...
May 2012: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/22197788/steady-state-evoked-potentials-to-tag-specific-components-of-nociceptive-cortical-processing
#17
Elisabeth Colon, Sylvie Nozaradan, Valery Legrain, André Mouraux
Studies have shown that the periodic repetition of a stimulus induces, at certain stimulation frequencies, a sustained electro-cortical response of corresponding frequency, referred to as steady-state evoked potential (SSEP). Using infrared laser stimulation, we recently showed that SSEPs can be used to explore nociceptive cortical processing. Here, we implemented a novel approach to elicit such responses, using a periodic intra-epidermal electrical stimulation of cutaneous Aδ-nociceptors (Aδ-SSEPs). Using a wide range of frequencies (3-43 Hz), we compared the scalp topographies and temporal dynamics of these Aδ-SSEPs to the Aβ-SSEPs elicited by non-nociceptive transcutaneous electrical stimulation, as well as to the transient ERPs elicited by the onsets of the 10-s stimulation trains, applied to the left and right hand...
March 2012: NeuroImage
https://www.readbyqxmd.com/read/21664438/fear-conditioning-is-associated-with-dynamic-directed-functional-interactions-between-and-within-the-human-amygdala-hippocampus-and-frontal-lobe
#18
C C Liu, N E Crone, P J Franaszczuk, D T Cheng, D S Schretlen, F A Lenz
The current model of fear conditioning suggests that it is mediated through modules involving the amygdala (AMY), hippocampus (HIP), and frontal lobe (FL). We now test the hypothesis that habituation and acquisition stages of a fear conditioning protocol are characterized by different event-related causal interactions (ERCs) within and between these modules. The protocol used the painful cutaneous laser as the unconditioned stimulus and ERC was estimated by analysis of local field potentials recorded through electrodes implanted for investigation of epilepsy...
August 25, 2011: Neuroscience
https://www.readbyqxmd.com/read/21265604/dishabituation-of-laser-evoked-eeg-responses-dissecting-the-effect-of-certain-and-uncertain-changes-in-stimulus-modality
#19
Elia Valentini, Diana M E Torta, André Mouraux, Gian Domenico Iannetti
The repetition of nociceptive stimuli of identical modality, intensity, and location at short and constant interstimulus intervals (ISIs) determines a strong habituation of the corresponding EEG responses, without affecting the subjective perception of pain. To understand what determines this response habituation, we (i) examined the effect of introducing a change in the modality of the repeated stimulus, and (ii) dissected the relative contribution of bottom-up, stimulus-driven changes in modality and top-down, cognitive expectations of such a change, on both laser-evoked and auditory-evoked EEG responses...
October 2011: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/20685171/laser-evoked-potentials-habituation-in-fibromyalgia
#20
Marina de Tommaso, Antonio Federici, Roberto Santostasi, Rita Calabrese, Eleonora Vecchio, Giovanni Lapadula, Fiorenzo Iannone, Paolo Lamberti, Paolo Livrea
UNLABELLED: Abnormalities of central pain processing play an important role in the pathophysiology of fibromyalgia (FM). The aims of the present study were to: 1) evaluate habituation of laser-evoked potentials (LEP) to repeated painful stimulation of 1 tender and 2 nontender points; and 2) determine correlations between LEP abnormalities and major clinical features of FM. Fourteen consecutive FM outpatients and 13 normal controls were included. LEP were recorded from scalp designations Fz, Cz, Pz, T3, and T4...
January 2011: Journal of Pain: Official Journal of the American Pain Society
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