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Yong Ping Chen, Bi Zhao, Bei Cao, Wei Song, XiaoYan Guo, Qian-Qian Wei, Yuan Yang, Li Xing Yuan, Hui-Fang Shang
Multiple-system atrophy (MSA) is a fatal neurodegenerative disorder with unknown etiology. It is widely considered to be a nongenetic disorder, but accumulating evidence suggests that several genes are linked to MSA. Recently, functionally impaired variants in the coenzyme Q2 4-hydroxybenzoate polyprenyltransferase (COQ2) gene have been reported to increase the risk of MSA in familial and sporadic Japanese patients. In this study, we investigated the mutation spectrum of COQ2 and analyzed the association between the common variant Val393Ala in exon 7 of COQ2 and MSA in a Chinese population...
February 2015: Neurobiology of Aging
Ming-Ming Tong, Chang-An Jiang
OBJECTIVE: To investigate the function of Parkinson's disease (PD)-related protein Pink1 in autophagy. METHODS: Pink1, autophagy inhibitor Bcl-XL and autophagy induced-factor Beclin1 were amplified with RT-PCR and contructed into pcDNA3. 1 (+) vector. The stable HEK293 cell line of Pink1 expression was established through the lentivirus system. Pink1, Bcl-XL and Beclin1 were tansfected into the HEK293 Cell Line. Co-Immunoprecipitation and Western blot were performed to determine the interaction between Pink1 and Bcl-XL, the effect of Pink1 on the interaction between Bcl-XL and Beclin1, and the function of Pink1 in autophagy...
May 2013: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Imre Szirmai
UNLABELLED: The "arteriosclerotic parkinsonism", which is called vascular parkinsonism (VP), was first described by Critchley'. The broad based slow gait, reduced stride lenght, start hesitation, freezing and paratonia was mentioned as "lower body parkinsonism" (LBP) which can be associated by slow speech, dysexecutive syndrome, and hand tremor of predominantly postural character. In VP the DAT-scan proved normal dopamine content of the striatum in contrast with Parkinson's disease (PD)...
November 30, 2011: Ideggyógyászati Szemle
Lilia Zaghdoudi, W Homri, S Belaid, M Ben Bechir, Raja Labbane
BACKGROUND: the quality of life of patients suffering from schizophrenia was extensively studied but it seems that impact on quality of life of neuroleptics, particularly atypical antipsychotic treatment was not clearly elucidated. AIMS: In this study we have compared the impact on quality of life of atypical antipsychotic versus classic neuroleptics. METHODS: We have enrolled, prospectively, all patients with schizophrenia as confirmed by DSM-IV TR...
September 2009: La Tunisie Médicale
Hangyuan Guo, Ping Wang, Yangbo Xing, Fang Peng, Jun Jiang, Biao Yang, Binquan You, Yufang Qiu, Jong-Dae Lee
OBJECTIVE: Radiofrequency catheter ablation (RFCA) is the curative treatment of choice for many cardiac arrhythmias and may cause myocardial injury and inappropriate sinus tachycardia. This study aimed to determine the delayed injury of autonomic nerve after RFCA. METHODS: Spectral analysis of heart rate variation on 24-hour Holter electrocardiogram recordings was carried out in 86 cases (39 women, 47 men; mean age, 42 years; range, 17-67 years) with paroxysmal supraventricular tachycardia 1 hour before and 1 year after successful RFCA (WPW type A = 31; Wolf-Pakinson-White Syndrome type B = 9; atrioventricular [AV] nodal tachycardia = 46; group A: septal accessory pathway + AV nodal tachycardia [n = 52], group B: free wall accessory pathway [n = 34])...
October 2007: Journal of Electrocardiology
Xudong Li, Xingzhou Liu, Guoxiang Wang
OBJECTIVE: To evaluate the clinical and polysomnographic features of rapid eye movement sleep behavior disorder (RBD) in Chinese patients. METHODS: Six parasomnic patients, 4 males and 2 females, with the mean onset age of 58 years (range 50 approximately 66 years) and 6 age and sex matched controls, were video-monitored for successive two nights, to record the electroencephalography, electrooculography, electromyography, electrocardiography and nasal airflow. RESULTS: Polysomnographic recordings disclosed an augmented muscle tone, which appeared intermittently or continuously in REM sleep, accompanied by complex behaviors correlated to dream contents observed by video-monitoring, and without seizure activity...
July 2002: Zhonghua Yi Xue za Zhi [Chinese medical journal]
J G Villa, J Sánchez Domínguez
No abstract text is available yet for this article.
1978: Revista Española de Cardiología
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