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https://www.readbyqxmd.com/read/29237258/diagnosis-and-management-of-moderate-to-severe-adult-atopic-dermatitis-a-consensus-by-the-italian-society-of-dermatology-and-venereology-sidemast-the-italian-association-of-hospital-dermatologists-adoi-the-italian-society-of-allergy-asthma-and-clinical-immunology
#1
Piergiacomo Calzavara Pinton, Antonio Cristaudo, Caterina Foti, Giorgio W Canonica, Nicola Balato, Antonio Costanzo, Ornella DE Pità, Clara DE Simone, Cataldo Patruno, Giovanni Pellacani, Ketty Peris, Giampiero Girolomoni
Atopic dermatitis (AD) is a chronic immune-mediated inflammatory skin disease, currently recognized as a systemic disease possibly burdened by various comorbidities, including, but not limited to, other allergic conditions. Management guidelines issued by American and European dermatology and allergy scientific societies are available. However, some discrepancies exist in these guidelines, and some aspects of the management process, including diagnosis and severity assessment, as well as therapy duration and switch criteria, are not fully clarified by existing guidelines...
December 14, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29226512/diagnosis-of-vertical-root-fractures-in-endodontically-treated-teeth-utilising-digital-subtraction-radiography-a-case-series-report
#2
Georgios Mikrogeorgis, Eleni Eirinaki, Vasileios Kapralos, Andreas Koutroulis, Kleoniki Lyroudia, Ioannis Pitas
Vertical root fractures are commonly associated with root-filled teeth. Diagnosis is challenging because the clinical signs are not completely pathognomonic, and conventional periapical radiography is often unreliable. Digital subtraction radiography (DSR) is able to detect small radiographic changes between two successive radiographs by subtracting out consistent radiographic elements. Its use could possibly assist in the diagnostic procedure. Four cases are presented to demonstrate the potential use of DSR in the detection of vertical root fractures in endodontically treated teeth...
December 11, 2017: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/29221044/side-lobe-level-reduction-in-bio-inspired-optical-phased-array-antennas
#3
Julián L Pita, Ivan Aldaya, Octávio J S Santana, Luís E E de Araujo, Paulo Dainese, Lucas H Gabrielli
Phased arrays are expected to play a critical role in visible and infrared wireless systems. Their improved performance compared to single element antennas finds uses in communications, imaging, and sensing. However, fabrication of photonic antennas and their feeding network require long element separation, leading to the appearance of secondary radiation lobes and, consequently, crosstalk and interference. In this work, we experimentally show that by arranging the elements according to the Fermat's spiral, the side lobe level (SLL) can be reduced...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29215678/decrease-in-mandibular-cortical-in-patients-with-type-1-diabetes-mellitus-combined-with-poor-glycemic-control
#4
Francisco Ivison Rodrigues Limeira, Patrícia Ravena Meneses Rebouças, Denise Nóbrega Diniz, Daniela Pita de Melo, Patrícia Meira Bento
In this study we analyzed the mandibular cortical bone of patients with type 1 diabetes mellitus (T1DM) and non-diabetic. Fifty patients with T1DM and 100 non-diabetic ones paired by age and gender were analyzed. Two double-blinded observers evaluated 150 digital panoramic images of both groups. The mandibular cortical bone was analyzed using the Mandibular Cortical Index (MCI), Mental Index (MI), Gonial Index (GI), Antegonial Index (AI) and Upper and Lower Panoramic Mandibular Indexes (UPMI and LPMI), with the aid of RADIOIMP® software...
September 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29214020/a-quick-and-selected-overview-of-the-expert-panel-on-effective-ways-of-investing-in-health
#5
Pedro Pita Barros
The European Commission created the Expert Panel on Effective Ways of Investing in Health (EXPH) in 2012. The EXPH started its activities in July 2013 and ended its first term in May 2016. A personal review of the Expert Panel contributions in its first term is provided.
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29210207/prevalence-of-knee-osteoarthritis-in-a-suburban-srilankan-adult-female-population-a-population-based-study
#6
Akalanka Prashansanie Hettihewa, Nalika S Gunawardena, Inoshi Atukorala, Fazliya Hassan, Indra N Lekamge, David J Hunter
INTRODUCTION: Prevalence of knee osteoarthritis (KOA) has not been assessed in Sri Lanka, since 2006. This study aimed to determine the prevalence of clinical KOA and radiographic KOA and to assess the severity of it, among adult females of a suburban setting in Sri Lanka. METHODS: A cross-sectional survey was conducted among a representative sample of 666 females aged 50 years or more resident in Pita Kotte Medical Officer of Health area. Four physiotherapy graduates applied American College of Rheumatology (ACR) criteria by performing the clinical assessment in the households...
December 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29206010/regulation-circulation-and-distribution-of-penicillin-in-portugal-1944-1954
#7
Victoria Bell, João Rui Pita, Ana Leonor Pereira
Portugal did not participate in World War II but was one of the first countries in the world to receive penicillin for civilian use. The Portuguese Red Cross began to import the antibiotic from the United States of America in 1944 and appointed a controlling committee to oversee its distribution, due to the small amount available. In 1945, as world production increased, penicillin began to be distributed through the normal channels. An important role in its regulation was played by the official department responsible for controlling pharmaceutical and chemical products in Portugal, the Comissão Reguladora dos Produtos Químicos e Farmacêuticos (Regulatory Committee for Chemical and Pharmaceutical Products)...
2017: Dynamis
https://www.readbyqxmd.com/read/29180851/differences-of-statin-activity-in-2d-and-3d-pancreatic-cancer-cell-cultures
#8
Miglė Paškevičiūtė, Vilma Petrikaitė
Purpose: To evaluate the anticancer activity of lovastatin (LOVA), mevastatin (MEVA), pitavastatin (PITA), and simvastatin (SIMVA) in 2D and 3D models of three human pancreatic cancer cell lines (BxPC-3, MIA PaCa-2, and PANC-1). Methods: The effect of statins on cell viability was estimated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test. The activity of statins in 3D pancreatic cancer cell cultures was examined by measuring the size change of spheroids...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29113181/microrna-profiling-and-bioinformatics-analyses-reveal-the-potential-roles-of-micrornas-in-chordoma
#9
Kangwu Chen, Hao Chen, Kai Zhang, Siwei Sun, Jianqiang Mo, Jian Lu, Zhonglai Qian, Huilin Yang
Chordoma is a rare aggressive bone tumor arising from remnants of the notochord, and patients with chordoma have a poor prognosis. However, the unique expression profiles of microRNAs (miRNAs/miRs) and their downstream signaling pathways in chordoma remain incompletely characterized. The aim of the present study was to delineate the global miRNA expression profile and associated signaling networks in chordoma. miRNA profiling was performed on chordoma and fetal notochord tissues. Differentially expressed miRNAs in chordoma were analyzed using microarrays with hierarchical clustering analysis...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29112983/identification-of-viscum-album-l-mirnas-and-prediction-of-their-medicinal-values
#10
Wenyan Xie, Jacob Adolf, Matthias F Melzig
MicroRNAs (miRNAs) are a class of approximately 22 nucleotides single-stranded non-coding RNA molecules that play crucial roles in gene expression. It has been reported that the plant miRNAs might enter mammalian bloodstream and have a functional role in human metabolism, indicating that miRNAs might be one of the hidden bioactive ingredients in medicinal plants. Viscum album L. (Loranthaceae, European mistletoe) has been widely used for the treatment of cancer and cardiovascular diseases, but its functional compounds have not been well characterized...
2017: PloS One
https://www.readbyqxmd.com/read/29106310/comparison-of-microtomography-and-optical-coherence-tomography-on-apical-endodontic-filling-analysis
#11
Fernanda Clotilde Mariz Suassuna, Ana Marly Araújo Maia, Daniela Pita Melo, Antônio Celso Dantas Antonino, Anderson Stevens Leônidas Gomes, Patrícia Meira Bento
OBJECTIVES: To comparein vitro differences in the apical filling regarding working length (WL) change and presence of voids and to validate optical coherence tomography (OCT) in comparison with computerized microtomography (µCT) for the detection of failures in the apical filling. METHODS: Forty-five uniradicular teeth with round canals, divided into groups (n = 15) following the obturation protocols: LC (lateral condensation), TMC (thermomechanical compaction) and SC (single cone)...
November 16, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29068049/the-safety-and-efficacy-of-powered-intracapsular-tonsillectomy-in-children-a-meta-analysis
#12
Ho Seok Lee, Ho Young Yoon, Ho Joon Jin, Se Hwan Hwang
OBJECTIVES: We performed a systemic review and meta-analysis regarding the postoperative pain, perioperative, and postoperative morbidity of powered intracapsular tonsillectomy and adenoidectomy (PITA) using a microdebrider as a method of tonsillectomy. DATA SOURCES: Five databases (PubMed, Scopus, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials) in their entirety through March 2017. REVIEW METHODS: We included studies in which there was a comparison between groups of patients who underwent PITA (PITA group) and those who had extracapsular tonsillectomy (control group)...
October 25, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29067606/a-novel-homozygous-1-bp-deletion-in-the-nobox-gene-in-two-brazilian-sisters-with-primary-ovarian-failure
#13
Monica M França, Mariana F A Funari, Antonio M Lerario, Mirian Y Nishi, Carmem C Pita, Eveline G P Fontenele, Berenice B Mendonca
PURPOSE: Primary ovarian failure (POF) is characterized by amenorrhea, hypoestrogenism, and elevated gonadotropin levels in women leading to infertility under the age of 40 years. POF is a heterogeneous disease with different causes, and several genes have been associated with the POF phenotype. Thus, Whole-exome sequencing (WES) was performed in a consanguineous family with two sisters affected by POF. METHODS: All exons of both sisters were massively sequenced by WES, and the segregation was confirmed by Sanger sequencing...
December 2017: Endocrine
https://www.readbyqxmd.com/read/29065215/on-the-catabolism-of-amino-acids-in-the-yeast-dekkera-bruxellensis-and-the-implications-to-industrial-fermentation-processes
#14
Denise Castro Parente, Danielli Batista Bezerra Cajueiro, Irina Charlot Peña Moreno, Fernanda Cristina Bezerra Leite, Will de Barros Pita, Marcos Antonio de Morais
In the last years several reports have reported the capacity of the yeast Dekkera (Brettanomyces) bruxellensis to survive and adapt to the industrial process of alcoholic fermentation. Much of this feature seems to relate to the ability to assimilate limiting sources of nutrients, or somehow some that are inaccessible to Saccharomyces cerevisiae, in particular the sources of nitrogen. Among them, amino acids (AA) are relevant in terms of beverage musts, and could also be important for bioethanol. In view of the limited knowledge on the control of AA, the present work combines physiological and genetic studies to understand how it operates in D...
October 24, 2017: Yeast
https://www.readbyqxmd.com/read/29050703/validity-of-the-edinburgh-claudication-questionnaire-for-diagnosis-of-peripheral-artery-disease-in-patients-with-type-2-diabetes
#15
Salvador Pita-Fernández, María José Modroño-Freire, Sonia Pértega-Díaz, Lizbeth Herrera-Díaz, Teresa Seoane-Pillado, Adriana Paz-Solís, José Luis Varela Modroño
OBJECTIVE: To assess the prevalence of peripheral artery disease and the validity of clinical signs for its diagnosis in patients with type 2 diabetes. METHODS: Setting: Health center (Mariñamansa,Orense). PERIOD: January 2011-January 2013. INCLUSION CRITERIA: Patients with type 2 diabetes, informed consent. MEASUREMENTS: Age, sex, diabetes duration, body mass index, Charlson index, blood pressure, ankle-brachial index (ABI), cholesterol levels, smoking...
November 2017: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29045483/lipid-profile-cardiovascular-disease-and-mortality-in-a-mediterranean-high-risk-population-the-escarval-risk-study
#16
Domingo Orozco-Beltran, Vicente F Gil-Guillen, Josep Redon, Jose M Martin-Moreno, Vicente Pallares-Carratala, Jorge Navarro-Perez, Francisco Valls-Roca, Carlos Sanchis-Domenech, Antonio Fernandez-Gimenez, Ana Perez-Navarro, Vicente Bertomeu-Martinez, Vicente Bertomeu-Gonzalez, Alberto Cordero, Manuel Pascual de la Torre, Jose L Trillo, Concepcion Carratala-Munuera, Salvador Pita-Fernandez, Ruth Uso, Ramon Durazo-Arvizu, Richard Cooper, Gines Sanz, Jose M Castellano, Juan F Ascaso, Rafael Carmena, Maria Tellez-Plaza
INTRODUCTION: The potential impact of targeting different components of an adverse lipid profile in populations with multiple cardiovascular risk factors is not completely clear. This study aims to assess the association between different components of the standard lipid profile with all-cause mortality and hospitalization due to cardiovascular events in a high-risk population. METHODS: This prospective registry included high risk adults over 30 years old free of cardiovascular disease (2008-2012)...
2017: PloS One
https://www.readbyqxmd.com/read/29040812/a-randomized-controlled-cross-over-study-of-appetite-related-sensations-after-consuming-snacks-made-from-buckwheat
#17
Danielle M Defries, Jay C Petkau, Terri Gregor, Heather Blewett
With the rising incidence of overweight and obesity in developed countries, there is an interest in developing food products that may aid in satiety and reduce energy intake. Buckwheat is a gluten-free edible seed that has been previously shown to induce changes in post-prandial concentrations of satiety hormones; however, subjective measures of appetite-related sensations and objective measures of energy intake at subsequent meals following buckwheat consumption have not been measured. Thirty eight healthy adults were recruited to participate in a randomized, controlled, cross-over trial with the main objective to determine if consuming snacks made from buckwheat would increase satiety and reduce energy intake compared to snacks comparable in serving size, physical characteristics, and nutrient composition...
October 17, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29040781/further-insights-into-the-components-of-resistance-to-ophiostoma-novo-ulmi-in-ulmus-minor-hydraulic-conductance-stomatal-sensitivity-and-bark-dehydration
#18
Pilar Pita, Jesús Rodríguez-Calcerrada, David Medel, Luis Gil
Dutch elm disease (DED) is a vascular disease that has killed over 1 billion elm trees. The pathogen spreads throughout the xylem network triggering vessel blockage, which results in water stress, tissue dehydration and extensive leaf wilting in susceptible genotypes. We investigated the differences between four Ulmus minor Mill. clones of contrasting susceptibility to Ophiostoma novo-ulmi Brasier regarding morphological, anatomical and physiological traits affecting water transport, in order to gain a better understanding of the mechanisms underlying DED susceptibility...
October 13, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29023453/plant-water-potential-improves-prediction-of-empirical-stomatal-models
#19
William R L Anderegg, Adam Wolf, Adriana Arango-Velez, Brendan Choat, Daniel J Chmura, Steven Jansen, Thomas Kolb, Shan Li, Frederick Meinzer, Pilar Pita, Víctor Resco de Dios, John S Sperry, Brett T Wolfe, Stephen Pacala
Climate change is expected to lead to increases in drought frequency and severity, with deleterious effects on many ecosystems. Stomatal responses to changing environmental conditions form the backbone of all ecosystem models, but are based on empirical relationships and are not well-tested during drought conditions. Here, we use a dataset of 34 woody plant species spanning global forest biomes to examine the effect of leaf water potential on stomatal conductance and test the predictive accuracy of three major stomatal models and a recently proposed model...
2017: PloS One
https://www.readbyqxmd.com/read/29021147/atypical-haematological-presentation-in-a-case-of-polycythaemia-vera-with-a-new-variant-mutation-detected-in-exon-12-c-1605g-t-p-met535ile
#20
Amélia Soraia Andrade Pita, Ana Paula da Silva Azevedo, Alice Reichert, Cândido José Pimenta da Silva, Vanessa Henriques, Diana Sousa Mendes, Ana Maria Batalha Reis, Rita Cerqueira, Fátima Torres, João Faro Viana
One of the major genetic insights into the pathogenesis of polycythaemia vera included the identification of the somatic point gain-of-function mutations in Janus kinase 2 gene-first JAK2V617F on exon 14, present in 95%-97% of the cases, and later on exon 12. In the literature, we can find some reported studies where different exon 12 mutations are identified. Unlike patients with JAK2V617F mutation in exon 14, the mutation at exon 12 is not usually associated with an increase in the three haematopoietic series (erythrocytosis, leucocytosis and thrombocytosis)...
October 11, 2017: Journal of Clinical Pathology
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