keyword
MENU ▼
Read by QxMD icon Read
search

pita

keyword
https://www.readbyqxmd.com/read/29913266/the-mechanism-of-iron-compensation-for-manganese-deficiency-of-streptococcus-pneumoniae
#1
Kun Cao, Fubin Lai, Xin-Lu Zhao, Qiu-Xia Wei, Xin-Yu Miao, Ruiguang Ge, Qing-Yu He, Xuesong Sun
Given their involvement in catalysis, infection, and biofilm formation, Fe and Mn are essential for bacterial survival and virulence. In this study, we found that Streptococcus pneumoniae (S. pneumoniae) could grow in the Mn-deficient medium (MDCM). Furthermore, findings showed that the Fe concentration in the bacterium increased when the Mn concentration decreased. In addition, it was noted that supplementing MDCM with Fe resulted in the recovery of bacterial growth. Quantitative proteomics using stable-isotope dimethyl labeling was performed to investigate the adaptive growth mechanism of S...
June 15, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29911329/helicobacter-pylori-antibiotic-resistance-in-portugal-systematic-review-and-meta-analysis
#2
REVIEW
Inês Lopo, Diogo Libânio, Inês Pita, Mário Dinis-Ribeiro, Pedro Pimentel-Nunes
BACKGROUND: Portugal presents both a high prevalence of Helicobacter pylori (Hp) infection and a high prevalence of antibiotic resistance. However, conclusive data on its magnitude are lacking. We aimed at summarizing the existing data. MATERIALS AND METHODS: A systematic review was conducted after searching in two databases (PubMed and SciELO). Meta-analysis was performed, and comparison of resistance rates between children and adults and by type of resistance (primary and secondary) was made...
June 17, 2018: Helicobacter
https://www.readbyqxmd.com/read/29895687/microfluidic-chambers-using-fluid-walls-for-cell-biology
#3
Cristian Soitu, Alexander Feuerborn, Ann Na Tan, Henry Walker, Pat A Walsh, Alfonso A Castrejón-Pita, Peter R Cook, Edmond J Walsh
Many proofs of concept have demonstrated the potential of microfluidics in cell biology. However, the technology remains inaccessible to many biologists, as it often requires complex manufacturing facilities (such as soft lithography) and uses materials foreign to cell biology (such as polydimethylsiloxane). Here, we present a method for creating microfluidic environments by simply reshaping fluids on a substrate. For applications in cell biology, we use cell media on a virgin Petri dish overlaid with an immiscible fluorocarbon...
June 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29894009/hidradisk-an-innovative-visual-tool-to-assess-the-burden-of-hidradenitis-suppurativa
#4
A Chiricozzi, V Bettoli, O De Pità, V Dini, G Fabbrocini, G Monfrecola, M L Musumeci, A Parodi, F Sampogna, A Pennella, F Buzzulini, G Gualberti, U di Luzio Paparatti, L Atzori
Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory dermatosis of the body folds, characterized by nodules, abscesses, sinus tracts and numerous comorbidities, significantly impairing patients quality of life (QoL).1-5 Among skin diseases, HS has the largest impact on QoL6 . Few specific instruments are available to assess, in a comprehensive, psychosocial perspective, the burden of HS7 , and no qualitative studies exploring the experience of HS patients and their relationship with the physician are currently available...
June 12, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29869127/aged-rats-are-more-vulnerable-than-adolescents-to-ecstasy-induced-toxicity
#5
R Feio-Azevedo, V M Costa, D J Barbosa, A Teixeira-Gomes, I Pita, S Gomes, F C Pereira, M Duarte-Araújo, J A Duarte, F Marques, E Fernandes, M L Bastos, F Carvalho, J P Capela
3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") is a widespread drug of abuse with known neurotoxic properties. The present study aimed to evaluate the differential toxic effects of MDMA in adolescent and aged Wistar rats, using doses pharmacologically comparable to humans. Adolescent (post-natal day 40) (3 × 5 mg/kg, 2 h apart) and aged (mean 20 months old) (2 × 5 mg/kg, 2 h apart) rats received MDMA intraperitoneally. Animals were killed 7 days later, and the frontal cortex, hippocampus, striatum and cerebellum brain areas were dissected, and heart, liver and kidneys were collected...
June 4, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29864326/search-for-%C3%AE-ray-line-signals-from-dark-matter-annihilations-in-the-inner-galactic-halo-from-10-years-of-observations-with-h-e-s-s
#6
H Abdallah, A Abramowski, F Aharonian, F Ait Benkhali, E O Angüner, M Arakawa, M Arrieta, P Aubert, M Backes, A Balzer, M Barnard, Y Becherini, J Becker Tjus, D Berge, S Bernhard, K Bernlöhr, R Blackwell, M Böttcher, C Boisson, J Bolmont, S Bonnefoy, P Bordas, J Bregeon, F Brun, P Brun, M Bryan, M Büchele, T Bulik, M Capasso, S Caroff, A Carosi, J Carr, S Casanova, M Cerruti, N Chakraborty, R C G Chaves, A Chen, J Chevalier, S Colafrancesco, B Condon, J Conrad, I D Davids, J Decock, C Deil, J Devin, P deWilt, L Dirson, A Djannati-Ataï, W Domainko, A Donath, L O'C Drury, K Dutson, J Dyks, T Edwards, K Egberts, P Eger, G Emery, J-P Ernenwein, S Eschbach, C Farnier, S Fegan, M V Fernandes, A Fiasson, G Fontaine, A Förster, S Funk, M Füßling, S Gabici, Y A Gallant, T Garrigoux, F Gaté, G Giavitto, B Giebels, D Glawion, J F Glicenstein, D Gottschall, M-H Grondin, J Hahn, M Haupt, J Hawkes, G Heinzelmann, G Henri, G Hermann, J A Hinton, W Hofmann, C Hoischen, T L Holch, M Holler, D Horns, A Ivascenko, H Iwasaki, A Jacholkowska, M Jamrozy, M Janiak, D Jankowsky, F Jankowsky, M Jingo, L Jouvin, I Jung-Richardt, M A Kastendieck, K Katarzyński, M Katsuragawa, U Katz, D Kerszberg, D Khangulyan, B Khélifi, J King, S Klepser, D Klochkov, W Kluźniak, Nu Komin, K Kosack, S Krakau, M Kraus, P P Krüger, H Laffon, G Lamanna, J Lau, J-P Lees, J Lefaucheur, A Lemière, M Lemoine-Goumard, J-P Lenain, E Leser, R Liu, T Lohse, M Lorentz, R López-Coto, I Lypova, D Malyshev, V Marandon, A Marcowith, C Mariaud, R Marx, G Maurin, N Maxted, M Mayer, P J Meintjes, M Meyer, A M W Mitchell, R Moderski, M Mohamed, L Mohrmann, K Morå, E Moulin, T Murach, S Nakashima, M de Naurois, H Ndiyavala, F Niederwanger, J Niemiec, L Oakes, P O'Brien, H Odaka, S Ohm, M Ostrowski, I Oya, M Padovani, M Panter, R D Parsons, N W Pekeur, G Pelletier, C Perennes, P-O Petrucci, B Peyaud, Q Piel, S Pita, V Poireau, H Poon, D Prokhorov, H Prokoph, G Pühlhofer, M Punch, A Quirrenbach, S Raab, R Rauth, A Reimer, O Reimer, M Renaud, R de Los Reyes, F Rieger, L Rinchiuso, C Romoli, G Rowell, B Rudak, C B Rulten, V Sahakian, S Saito, D A Sanchez, A Santangelo, M Sasaki, M Schandri, R Schlickeiser, F Schüssler, A Schulz, U Schwanke, S Schwemmer, M Seglar-Arroyo, M Settimo, A S Seyffert, N Shafi, I Shilon, K Shiningayamwe, R Simoni, H Sol, F Spanier, M Spir-Jacob, Ł Stawarz, R Steenkamp, C Stegmann, C Steppa, I Sushch, T Takahashi, J-P Tavernet, T Tavernier, A M Taylor, R Terrier, L Tibaldo, D Tiziani, M Tluczykont, C Trichard, M Tsirou, N Tsuji, R Tuffs, Y Uchiyama, J van der Walt, C van Eldik, C van Rensburg, B van Soelen, G Vasileiadis, J Veh, C Venter, A Viana, P Vincent, J Vink, F Voisin, H J Völk, T Vuillaume, Z Wadiasingh, S J Wagner, P Wagner, R M Wagner, R White, A Wierzcholska, P Willmann, A Wörnlein, D Wouters, R Yang, D Zaborov, M Zacharias, R Zanin, A A Zdziarski, A Zech, F Zefi, A Ziegler, J Zorn, N Żywucka
Spectral lines are among the most powerful signatures for dark matter (DM) annihilation searches in very-high-energy γ rays. The central region of the Milky Way halo is one of the most promising targets given its large amount of DM and proximity to Earth. We report on a search for a monoenergetic spectral line from self-annihilations of DM particles in the energy range from 300 GeV to 70 TeV using a two-dimensional maximum likelihood method taking advantage of both the spectral and spatial features of the signal versus background...
May 18, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29851864/endoscopic-stenting-for-palliation-of-intra-abdominal-gastrointestinal-malignant-obstruction-predictive-factors-for-clinical-success
#7
Inês Pais-Cunha, Rui Castro, Diogo Libânio, Inês Pita, Rui P Bastos, Rui Silva, Mario Dinis-Ribeiro, Pedro Pimentel-Nunes
BACKGROUND: Endoscopic stenting proved to be a safe alternative to surgery for malignant intra-abdominal gastrointestinal obstruction. Although high technical success rates have been reported, some patients do not experience relief in symptoms. AIM: This study aimed to analyse the factors predicting the effectiveness of stent placement in patients with gastrointestinal obstruction. PATIENTS AND METHODS: A retrospective study was carried out including 160 patients who underwent palliative stenting for intra-abdominal obstruction in a tertiary centre from December 2012 to July 2017...
May 30, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29766673/genomic-characterization-of-individuals-presenting-extreme-phenotypes-of-high-and-low-risk-to-develop-tobacco-induced-lung-cancer
#8
Juan Pablo Fusco, Guillermo Pita, María José Pajares, Maria Pilar Andueza, Ana Patiño-García, Juan P de-Torres, Alfonso Gurpide, Javier Zulueta, Rosario Alonso, Nuria Alvarez, Ruben Pio, Ignacio Melero, Miguel F Sanmamed, Maria Rodriguez Ruiz, Ignacio Gil-Bazo, Jose María Lopez-Picazo, Ciro Casanova, Rebeca Baz Davila, Antonio Agudo, Maria Dolores Lozano, Alvaro Gonzalez, Nuria Sala, Eva Ardanaz, Javier Benitez, Luis Montuenga, Anna Gonzalez-Neira, Jose Luis Perez-Gracia
Single nucleotide polymorphisms (SNPs) may modulate individual susceptibility to carcinogens. We designed a genome-wide association study to characterize individuals presenting extreme phenotypes of high and low risk to develop tobacco-induced non-small cell lung cancer (NSCLC), and we validated our results. We hypothesized that this strategy would enrich the frequencies of the alleles that contribute to the observed traits. We genotyped 2.37 million SNPs in 95 extreme phenotype individuals, that is: heavy smokers that either developed NSCLC at an early age (extreme cases); or did not present NSCLC at an advanced age (extreme controls), selected from a discovery set (n = 3631)...
May 15, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29761480/whole-exome-sequencing-identifies-plec-exo5-and-dnah7-as-novel-susceptibility-genes-in-testicular-cancer
#9
Beatriz Paumard-Hernández, Oriol Calvete, Lucia Inglada Pérez, Héctor Tejero, Fátima Al-Shahrour, Guillermo Pita, Alicia Barroso, Juan Carlos Triviño, Miguel Urioste, Claudia Valverde, Enrique González Billalabeitia, Vanesa Quiroga, Juan Francisco Rodríguez Moreno, Antonio Fernández Aramburo, Cristina López, Pablo Maroto, Javier Sastre, María José Juan Fita, Ignacio Duran, Isabel Lorenzo-Lorenzo, Patricia Iranzo, Xavier García Del Muro, Silverio Ros, Francisco Zambrana, Ana María Autran, Javier Benítez
Testicular germ cell tumors (TGCTs) are a clinically and pathologically heterogeneous disease, and little is known of its genetic basis. Only low susceptibility risk loci have been identified for both sporadic and familial cases. Therefore, we tried to identify new susceptibility genes responsible for familial testicular cancer that may contribute to increasing our knowledge about the genetic basis of the disease. Nineteen Spanish families with at least two affected individuals with TGCT were selected. WES was performed on those individuals using an Illumina Hiseq2000 sequencing platform...
May 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29757702/genetic-diversity-of-toxoplasma-gondii-isolates-from-free-range-chickens-in-bahia-brazil
#10
Daniele Santana Rocha, Mariana Guimarães Nilsson, Bianca Mendes Maciel, Hilda Fátima de Jesus Pena, Bruna Farias Alves, Aristeu Vieira Silva, Luís Fernando Pita Gondim, George Rego Albuquerque
In the present work, genotyping of 25 isolates of Toxoplasma gondii from free-range chickens in the State of Bahia was performed by means of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique using eleven genetic markers (SAG1, 5'+3'SAG2, alt.SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1, Apico and CS3). The analysis revealed eight genotypes, three of which had never been previously reported. Four genotypes were represented by single isolates, while the others by two or more isolates...
May 15, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29757501/important-considerations-for-the-utilisation-of-methanolysis-in-steroid-analysis
#11
Marjaana Viljanto, Catarina Horro Pita, James Scarth, Christopher J Walker, Andrew T Kicman, Mark C Parkin
The effective analysis of anabolic-androgenic steroids in urine usually requires a suitable deconjugation method for the analysis of phase II metabolites such as sulfates and glucuronides. Acid hydrolysis using methanolysis is one adopted method of deconjugation that efficiently and rapidly cleaves both sulfates and glucuronides contemporaneously. The formation of artefactual by-products is a known disadvantage of this harsh method. However, the possible promotion of deuterium-hydrogen exchange of isotopically labelled internal standards has received little attention in the literature...
May 14, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29741139/identification-characterization-and-molecular-modelling-studies-of-schistosoma-mansoni-dihydrofolate-reductase-inhibitors-from-assay-development-to-hit-identification
#12
Andre Lacerda Braga Teles, Roseane R Silva, Michelle Ko, Glaucio Monteiro Ferreira, Samuel da Rocha Pita, Gustavo Henrique Goulart Trossini, Paulo Carvalho, Marcelo Santos Castilho
Schistosoma mansoni is responsible for virtually all reported cases of schistosomiasis in Latin America and the emergence of praziquantel- and oxaminiquine-resistant strains makes it urgent to develop new schistosomicide agents. Dihydrofolate reductases (DHFR) from bacteria and protozoan parasites are considered validated macromolecular targets for this goal, but S. mansoni DHFR (SmDHFR) has been largely overlooked. To fill this gap in knowledge, the present work describes optimized conditions to carry out thermal shift assays with SmDHFR, as well as a balanced kinetic assay that supports 2,4-diaminopyrimidine derivatives as SmDHFR inhibitors...
May 9, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29740169/gain-of-function-mutations-in-dnmt3a-in-patients-with-paraganglioma
#13
Laura Remacha, Maria Currás-Freixes, Raúl Torres-Ruiz, Francesca Schiavi, Rafael Torres-Pérez, Bruna Calsina, Rocío Letón, Iñaki Comino-Méndez, Juan M Roldán-Romero, Cristina Montero-Conde, María Santos, Lucía Inglada Pérez, Guillermo Pita, María R Alonso, Emiliano Honrado, Susana Pedrinaci, Benedicto Crespo-Facorro, Antonio Percesepe, Maurizio Falcioni, Sandra Rodríguez-Perales, Esther Korpershoek, Santiago Ramón-Maiques, Giuseppe Opocher, Cristina Rodríguez-Antona, Mercedes Robledo, Alberto Cascón
PURPOSE: The high percentage of patients carrying germline mutations makes pheochromocytomas/paragangliomas the most heritable of all tumors. However, there are still cases unexplained by mutations in the known genes. We aimed to identify the genetic cause of disease in patients strongly suspected of having hereditary tumors. METHODS: Whole-exome sequencing was applied to the germlines of a parent-proband trio. Genome-wide methylome analysis, RNA-seq, CRISPR/Cas9 gene editing, and targeted sequencing were also performed...
May 8, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29733425/economics-meets-healthcare-how-can-it-be-useful
#14
Pedro Pita Barros
No abstract text is available yet for this article.
May 4, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29708484/expanding-an-expanded-genome-long-read-sequencing-of-trypanosoma-cruzi
#15
Luisa Berná, Matias Rodriguez, María Laura Chiribao, Adriana Parodi-Talice, Sebastián Pita, Gastón Rijo, Fernando Alvarez-Valin, Carlos Robello
Although the genome of Trypanosoma cruzi, the causative agent of Chagas disease, was first made available in 2005, with additional strains reported later, the intrinsic genome complexity of this parasite (the abundance of repetitive sequences and genes organized in tandem) has traditionally hindered high-quality genome assembly and annotation. This also limits diverse types of analyses that require high degrees of precision. Long reads generated by third-generation sequencing technologies are particularly suitable to address the challenges associated with T...
April 30, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29704894/virulent-duck-enteritis-virus-infected-def-cells-generate-a-unique-pattern-of-viral-micrornas-and-a-novel-set-of-host-micrornas
#16
Xianglong Wu, Renyong Jia, Jiakun Zhou, Mingshu Wang, Shun Chen, Mafeng Liu, Dekang Zhu, Xinxin Zhao, Kunfeng Sun, Qiao Yang, Ying Wu, Zhongqiong Yin, Xiaoyue Chen, Jue Wang, Anchun Cheng
BACKGROUND: Duck enteritis virus (DEV) belongs to the family Herpesviridae and is an important epornitic agent that causes economic losses in the waterfowl industry. The Chinese virulent (CHv) and attenuate vaccines (VAC) are two different pathogenic DEV strains. MicroRNAs (miRNAs) are a class of non-coding RNAs that regulate gene expression in viral infection. Nonetheless, there is little information on virulent duck enteritis virus (DEV)-encoded miRNAs. RESULTS: Using high-throughput sequencing, we identified 39 mature viral miRNAs from CHv-infected duck embryo fibroblasts cells...
April 28, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29701626/moral-distress-md-and-burnout-in-mental-health-nurses-a-multicenter-survey
#17
Fabiana Delfrate, Paolo Ferrara, Daniela Spotti, Stefano Terzoni, Giulia Lamiani, Eleonora Canciani, Loris Bonetti
INTRODUCTION: Moral Distress (MD) is a common experience among nurses and if it is not recognised and treated, it may lead to serious consequences on nurses' health and quality of care. MD has been studied in several healthcare contexts. However, there are only few studies on MD in psychiatry and in Italy there are no data in this field.  Objective: To assess the presence of MD among mental health nurses in Italy and verify whether there is a relationship between MD and burnout. METHODS: We conducted a multicentre survey among nurses of Mental Health services of four hospitals in Milan...
February 6, 2018: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29695283/survey-of-farmers-knowledge-of-cassava-mosaic-disease-and-their-preferences-for-cassava-cultivars-in-three-agro-ecological-zones-in-benin
#18
Jerome Anani Houngue, Justin S Pita, Gilles Habib Todjro Cacaï, Martine Zandjanakou-Tachin, Emmanuel A E Abidjo, Corneille Ahanhanzo
BACKGROUND: Cassava is an important crop in Africa that is widely cultivated for its starchy tuberous root, which constitutes a major source of dietary carbohydrates. Cassava mosaic disease (CMD) is the most devastating disease affecting cassava in Africa and causes enormous losses in yield. In Benin, specifically, cultivars resistant to CMD are not commonly planted, and even when CMD is observed in fields, farmers do not implement control measures, presumably because they lack proper knowledge and training...
April 25, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29695139/comparative-analysis-of-repetitive-dna-between-the-main-vectors-of-chagas-disease-triatoma-infestans-and-rhodnius-prolixus
#19
Sebastián Pita, Pablo Mora, Jesús Vela, Teresa Palomeque, Antonio Sánchez, Francisco Panzera, Pedro Lorite
Chagas disease or American trypanosomiasis affects six to seven million people worldwide, mostly in Latin America. This disease is transmitted by hematophagous insects known as "kissing bugs" (Hemiptera, Triatominae), with Triatoma infestans and Rhodnius prolixus being the two most important vector species. Despite the fact that both species present the same diploid chromosome number (2 n = 22), they have remarkable differences in their total DNA content, chromosome structure and genome organization...
April 24, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29692777/long-non-coding-rna-gaplinc-promotes-tumor-like-biologic-behaviors-of-fibroblast-like-synoviocytes-as-microrna-sponging-in-rheumatoid-arthritis-patients
#20
Bi Yao Mo, Xing Hua Guo, Meng Ru Yang, Fang Liu, Xuan Bi, Yan Liu, Lin Kai Fang, Xi Qing Luo, Julie Wang, Joseph A Bellanti, Yun Feng Pan, Song Guo Zheng
Rapidly accumulating evidence has now suggested that the long non-coding RNAs (LncRNAs), a large and diverse class of non-coding transcribed RNA molecules with diverse functional roles and mechanisms, play a major role in the pathogenesis of many human inflammatory diseases. Although some LncRNAs are overexpressed in plasma, T cell, and synovial tissues of patients with rheumatoid arthritis (RA), there is a dearth of knowledge in what role these transcripts play in fibroblast-like synoviocytes (FLSs) of these patients...
2018: Frontiers in Immunology
keyword
keyword
67369
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"