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https://www.readbyqxmd.com/read/29666602/myasthenia-gravis-induced-by-ipilimumab-in-a-patient-with-metastatic-melanoma
#1
Vera Montes, Sandra Sousa, Fernando Pita, Rui Guerreiro, Cátia Carmona
In daily clinical practice, there is a growing number of patients receiving new biological agents used in the treatment of malignancies. Ipilimumab is a fully humanized monoclonal antibody approved for patients with melanoma. It acts as an immune checkpoint inhibitor, binding and blocking cytotoxic T-lymphocyte antigen-4 in order to increase the antitumor immune response. There are several reports of autoimmune responses after its use. A 74-year-old man developed a mild rash and pruritus a few hours after the second infusion of ipilimumab and 24 h after the third dose of ipilimumab, he presented with shortness of breath, proximal limb muscle weakness, and diplopia...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29665158/peanut-gastro-intestinal-delivery-oral-immunotherapy-in-adolescents-results-of-the-build-up-phase-of-a-randomized-double-blind-placebo-controlled-trial-pita-study
#2
Jean-Luc Fauquert, Elodie Michaud, Bruno Pereira, Lise Bernard, Nelly Gourdon-Dubois, Paul-Olivier Rouzaire, Emmanuelle Rochette, Etienne Merlin, Bertrand Evrard
BACKGROUND: Oral immunotherapy to peanut is effective in desensitizing patients but has significant side effects including anaphylaxis and gastro-intestinal symptoms. In most protocols peanut is administered in a vehicle food. OBJECTIVE: In an exclusively adolescent population, we tested a new approach using sealed capsules of peanut (Gastro-Intestinal Delivery Oral Immunotherapy or GIDOIT) in order to bypass the upper gastro-intestinal tract. The primary aim was to assess the efficacy of the oral build-up phase of GIDOIT and the secondary aim to analyse its safety...
April 17, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29658617/assessment-of-salt-concentration-in-bread-commonly-consumed-in-the-eastern-mediterranean-region
#3
Ayoub Al Jawaldeh, Manal Al-Khamaiseh
Background: Hypertension is the most important cardiovascular risk factor in the World Health Organization (WHO) Eastern Mediterranean Region. Excessive salt and sodium intake is directly related to hypertension, and its reduction is a priority of WHO. Bread is the leading staple food in the Region; therefore, reducing the amount of salt added to bread could be an effective measure for reducing salt intake. Aim: The study sought to determine the levels of sodium and salt in locally produced staple bread from 8 countries in the Region...
April 5, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29655600/response-of-epilithic-diatom-communities-to-environmental-gradients-along-an-ecuadorian-andean-river
#4
Pablo Castillejo, Susana Chamorro, Luis Paz, Carla Heinrich, Ivonne Carrillo, Jose G Salazar, Juan C Navarro, Eduardo A Lobo
Epilithic diatom communities are particularly suitable for the evaluation of freshwater quality. In Ecuador, however, no water quality index includes this biotic parameter. This work is the first attempt in the country to determine the composition of epilithic diatom communities associated with different degrees of eutrophication. This was accomplished by measuring physical, chemical and microbiological variables at five sampling sites along the Pita River, Ecuador, from August to December 2016. The results indicate a clear gradient of eutrophication from sampling sites P1 (good water) in the upper reaches to P5 (bad water) located in the lower reaches...
April 11, 2018: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29621083/factors-associated-with-the-complexity-of-facial-trauma
#5
Ivo Cavalcante Pita Neto, Jéferson Martins Pereira Lucena Franco, Júlio Leite de Araujo Junior, Milana Drumond Ramos Santana, Luiz Carlos de Abreu, Ítalla Maria Pinheiro Bezerra, Eduardo Costa Studart Soares, David Gomes de Alencar Gondim, Luciano Miller Reis Rodrigues
INTRODUCTION: Facial fractures have their incidence, etiology, clinical presentation, and features influenced by variables such as economic, cultural, and demographic factors. A large number of these fractures require simple or more complex approaches, and it becomes important to understand their clinical and epidemiological profile and factors associated with the fracture event and surgical indication. OBJECTIVE: The objective of this research is to analyze the clinical and epidemiological profile of surgical fractures and their associations with causal factors such as alcohol consumption, day of the incident, and nonuse of helmet for motorcycle accidents...
April 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29621078/a-patient-with-severe-lower-face-degloving-injury
#6
Ivo Cavalcante Pita Neto, Jéferson Martins Pereira Lucena Franco, Eduardo Chaves Moreno, Pablo Pita, Francisco Aurelio Lucchesi Sandrini, David Gomes de Alencar Gondim
Avulsions of mandible are among the most devastating lesions observed in cranio-maxillofacial traumas. They present an important health problem because of the high risk of morbidity related to deformities that cause functional limitations and esthetic changes. The avulsions commonly result from high-energy effects, which cause complete or partial separation of the mandibular bone of the face. As a result of the intense aggression, the skin and subcutaneous tissues of the bone are usually removed, affecting muscles, fascia, blood vessels, and the surrounding nerves...
April 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29617791/beating-heart-aortic-arch-surgery-in-neonates-and-infants
#7
Juan-Miguel Gil-Jaurena, María-Teresa González-López, Ana Pita, Ramón Pérez-Caballero, Mónica Herviás, Dorotea Blanco
OBJECTIVES: Aortic arch repair has been shifted from deep hypothermia plus circulatory arrest to cerebral perfusion at tepid temperatures. A step forward is a simultaneous brain-coronary perfusion, allowing beating-heart arch surgery. METHODS: A 'Y' cannula from the arterial line delivers oxygenated blood to brain and heart. The arch is repaired on a beating heart at 25°C. Intracardiac repair is performed after running cardioplegia through the root line. Fifty patients are classified into 3 groups: A, Norwood (8 neonates); B, aortic arch (14 children) and C, aortic arch plus intracardiac repair (28 patients)...
April 2, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29599012/metaorganisms-in-extreme-environments-do-microbes-play-a-role-in-organismal-adaptation
#8
REVIEW
Corinna Bang, Tal Dagan, Peter Deines, Nicole Dubilier, Wolfgang J Duschl, Sebastian Fraune, Ute Hentschel, Heribert Hirt, Nils Hülter, Tim Lachnit, Devani Picazo, Lucia Pita, Claudia Pogoreutz, Nils Rädecker, Maged M Saad, Ruth A Schmitz, Hinrich Schulenburg, Christian R Voolstra, Nancy Weiland-Bräuer, Maren Ziegler, Thomas C G Bosch
From protists to humans, all animals and plants are inhabited by microbial organisms. There is an increasing appreciation that these resident microbes influence the fitness of their plant and animal hosts, ultimately forming a metaorganism consisting of a uni- or multicellular host and a community of associated microorganisms. Research on host-microbe interactions has become an emerging cross-disciplinary field. In both vertebrates and invertebrates a complex microbiome confers immunological, metabolic and behavioural benefits; conversely, its disturbance can contribute to the development of disease states...
February 15, 2018: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/29593794/comparative-analysis-of-the-effectiveness-of-the-topical-administration-of-benzocaine-and-emla-%C3%A2-on-oral-pain-and-tactile-sensitivity
#9
David Gomes de Alencar Gondim, Antonio Marcos Montagner, Ivo Cavalcante Pita-Neto, Romildo José de Siqueira Bringel, Francisco Aurelio Luchesi Sandrini, Eduardo Fernando Chaves Moreno, Amanda Mendes de Sousa, Andreza Bastos Correia
Objectives: To compare the effectiveness of the topical administration of benzocaine and EMLA on oral pain and tactile sensitivity. Materials and Methods: A randomized, double-blind, split-mouth clinical trial was carried out with 20 volunteers. The sensorial and quantitative tests were applied before the contact with topical anesthetic and after the application. Results: In the superficial tactile perception test, when we compared each group singly, there were statistically significant values in the decrease of superficial tactile perception when compared to the moment prior to the application of anesthetic agents...
2018: International Journal of Dentistry
https://www.readbyqxmd.com/read/29572487/author-correction-krab-type-zinc-finger-proteins-pita-and-pisa-specifically-regulate-p53-dependent-glycolysis-and-mitochondrial-respiration
#10
Shan Wang, Zhiqiang Peng, Siying Wang, Lihua Yang, Yuhan Chen, Xue Kong, Shanshan Song, Pei Pei, Chunyan Tian, Hui Yan, Peipei Ding, Weiguo Hu, Cui Hua Liu, Xin Zhang, Fuchu He, Lingqiang Zhang
We apologize for an error that we just found in the paper published online on 21 February 2018. The 1st row/1st column of Figure 8G (PITA Normal) was inadvertently duplicated from 2nd row/1st column of Figure 8I (PISA Adjacent colonic mucosa). The 2nd row/1st column of Figure 8G (PISA Normal) was inadvertently duplicated from 2nd row/2nd column of Figure 8G (PISA Distal colonic mucosa). A corrected version of Figure 8G is provided below. No conclusion was affected by this error, but we apologize for not detecting it before publication and any inconvenience caused...
March 23, 2018: Cell Research
https://www.readbyqxmd.com/read/29554099/the-pathway-coexpression-network-revealing-pathway-relationships
#11
Yered Pita-Juarez, Gabriel Altschuler, Sokratis Kariotis, Wenbin Wei, Katjusa Koler, Claire Green, Rudolph Tanzi, Winston Hide
A goal of genomics is to understand the relationships between biological processes. Pathways contribute to functional interplay within biological processes through complex but poorly understood interactions. However, limited functional references for global pathway relationships exist. Pathways from databases such as KEGG and Reactome provide discrete annotations of biological processes. Their relationships are currently either inferred from gene set enrichment within specific experiments, or by simple overlap, linking pathway annotations that have genes in common...
March 19, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29550995/first-report-of-toxoplasma-gondii-sporulated-oocysts-and-giardia-duodenalis-in-commercial-green-lipped-mussels-perna-canaliculus-in-new-zealand
#12
Alicia Coupe, Laryssa Howe, Elizabeth Burrows, Abigail Sine, Anthony Pita, Niluka Velathanthiri, Emilie Vallée, David Hayman, Karen Shapiro, Wendi D Roe
Pollution of marine ecosystems with the protozoan parasites Toxoplasma gondii, Cryptosporidium spp. and Giardia duodenalis can be studied using bivalve shellfish as biosentinels. Although evidence suggests that these parasites are present in New Zealand coastal waters, the extent of protozoal pollution has not been investigated. This study used optimised molecular methods to detect the presence of Cryptosporidium spp., G. duodenalis and T. gondii in commercially sourced green-lipped mussel (Perna canaliculus), an endemic species found throughout coastal New Zealand...
March 17, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29544475/specific-features-of-l-histidine-production-by-escherichia-coli-concerned-with-feedback-control-of-aicar-formation-and-inorganic-phosphate-metal-transport
#13
Evgeniya A Malykh, Ivan A Butov, Anna B Ravcheeva, Alexander A Krylov, Sergey V Mashko, Nataliya V Stoynova
BACKGROUND: In the L-histidine (His) biosynthetic pathway of Escherichia coli, the first key enzyme, ATP-phosphoribosyltransferase (ATP-PRT, HisG), is subject to different types of inhibition. Eliminating the feedback inhibition of HisG by the His end product is an important step that enables the oversynthesis of His in breeding strains. However, the previously reported feedback inhibition-resistant mutant enzyme from E. coli, HisGE271K , is inhibited by purine nucleotides, particularly ADP and AMP, via competitive inhibition with its ATP substrate...
March 15, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29532960/manipulation-and-steering-of-hyperbolic-surface-polaritons-in-hexagonal-boron-nitride
#14
Siyuan Dai, Mykhailo Tymchenko, Yafang Yang, Qiong Ma, Marta Pita-Vidal, Kenji Watanabe, Takashi Taniguchi, Pablo Jarillo-Herrero, Michael M Fogler, Andrea Alù, Dimitri N Basov
Hexagonal boron nitride (hBN) is a natural hyperbolic material that supports both volume-confined hyperbolic polaritons and sidewall-confined hyperbolic surface polaritons (HSPs). In this work, efficient excitation, control, and steering of HSPs are demonstrated in hBN through engineering the geometry and orientation of hBN sidewalls. By combining infrared nanoimaging and numerical simulations, the reflection, transmission, and scattering of HSPs are investigated at the hBN corners with various apex angles...
March 13, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29523192/the-sponge-holobiont-in-a-changing-ocean-from-microbes-to-ecosystems
#15
REVIEW
L Pita, L Rix, B M Slaby, A Franke, U Hentschel
The recognition that all macroorganisms live in symbiotic association with microbial communities has opened up a new field in biology. Animals, plants, and algae are now considered holobionts, complex ecosystems consisting of the host, the microbiota, and the interactions among them. Accordingly, ecological concepts can be applied to understand the host-derived and microbial processes that govern the dynamics of the interactive networks within the holobiont. In marine systems, holobionts are further integrated into larger and more complex communities and ecosystems, a concept referred to as "nested ecosystems...
March 9, 2018: Microbiome
https://www.readbyqxmd.com/read/29521266/laparoscopic-partial-nephrectomy-using-the-simon-clamp-our-experience-in-18-cases
#16
Gonzalo Vitagliano, Leandro Blas, Maximiliano Ringa, Nicolás Villasante, Hernando Ríos-Pita, Carlos Alberto Ameri
OBJECTIVE: Kidney tumors represent 2- 3% of adult tumors. Partial nephrectomy is the standard of care for the treatment of localized tumors. Minimizing ischemia time is critical for postoperative renal function. The aim of this paper is to present our experience in laparoscopic partial nephrectomy with selective renal parenchymal compression using the Simon clamp. METHODS: We analyzed the record of patients that underwent surgery for renal tumors between January 2011 and June 2016 at our institution...
March 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29518927/smart-sound-processing-for-defect-sizing-in-pipelines-using-emat-actuator-based-multi-frequency-lamb-waves
#17
Joaquín García-Gómez, Roberto Gil-Pita, Manuel Rosa-Zurera, Antonio Romero-Camacho, Jesús Antonio Jiménez-Garrido, Víctor García-Benavides
Pipeline inspection is a topic of particular interest to the companies. Especially important is the defect sizing, which allows them to avoid subsequent costly repairs in their equipment. A solution for this issue is using ultrasonic waves sensed through Electro-Magnetic Acoustic Transducer (EMAT) actuators. The main advantage of this technology is the absence of the need to have direct contact with the surface of the material under investigation, which must be a conductive one. Specifically interesting is the meander-line-coil based Lamb wave generation, since the directivity of the waves allows a study based in the circumferential wrap-around received signal...
March 7, 2018: Sensors
https://www.readbyqxmd.com/read/29516033/antioxidant-activities-of-traditional-plants-in-sri-lanka-by-dpph-free-radical-scavenging-assay
#18
Kotaro Hara, Takao Someya, Katsura Sano, Yoshimasa Sagane, Toshihiro Watanabe, R G S Wijesekara
This article describes free radical-scavenging activities of extracts of several plants harvested in Sri Lanka through the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. These plants have traditionally been used in the indigenous systems of medicine in Sri Lanka, such as Ayurveda, as described below. (English name, "local name in Sri Lanka," (scientific name)). bougainvillea plant, "bouganvilla," ( Bougainvillea grabla ), purple fruited pea eggplant,"welthibbatu," ( Solanum trilobatum ) [1], country borage plant, "kapparawalliya," ( Plectranthus amboinicus ) [2], malabar nut plant, "adhatoda," ( Justicia adhatoda ) [3], long pepper plant,"thippili," ( Piper longum ) [4], holy basil plant, "maduruthala," ( Ocimum tenuiflorum ) [5], air plant, "akkapana," ( Kalanchoe pinnata ) [6], plumed cockscomb plant, "kiri-henda," ( Celosia argentea ) [7], neem plant,"kohomba," ( Azadirachta indica ) [8], balipoovu plant, "polpala," ( Aerva lanata ) [9], balloon-vine plant, "wel penera," ( Cardiospermum halicacabum ) [10], emblic myrobalan plant, "nelli," ( Phyllanthus emblica ) [11], indian copperleaf plant, "kuppameniya," ( Acalypha indica ) [12], spreading hogweed plant, "pita sudu sarana," ( Boerhavia diffusa ) [13], curry leaf plant, "karapincha," ( Murraya koenigii ) [14], indian pennywort plant, "gotukola," ( Centera asiatica ) [15], jewish plum plant, "ambarella,"( Spondias dulcis ) [16]...
April 2018: Data in Brief
https://www.readbyqxmd.com/read/29511225/marker-assisted-introgression-of-three-dominant-blast-resistance-genes-into-an-aromatic-rice-cultivar-mushk-budji
#19
Gazala Hassan Khan, Asif Bashir Shikari, Rakesh Vaishnavi, Sofi Najeeb, Bilal A Padder, Zahoor A Bhat, Ghulam A Parray, Mohammad Ashraf Bhat, Ram Kumar, Nagendra K Singh
Modern high yielding rice varieties have replaced most of the traditional cultivars in recent past. Mushk Budji, is one such short grained landrace known for its aroma and exquisite quality, however, is highly susceptible to blast disease that has led to considerable decline in its area. Mushk Budji was crossed to a triple-gene donor line, DHMAS 70Q 164-1b and followed through marker-assisted foreground and background selection in first and second backcross generations that helped to incorporate blast resistance genes Pi54, Pi1 and Pita...
March 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29505402/on-the-accuracy-and-scalability-of-probabilistic-data-linkage-over-the-brazilian-114-million-cohort
#20
Robespierre Pita, Clicia Pinto, Samila Sena, Rosemeire Fiaccone, Leila Amorim, Sandra Reis, Mauricio L Barreto, Spiros Denaxas, Marcos Ennes Barreto
Data linkage refers to the process of identifying and linking records that refer to the same entity across multiple heterogeneous data sources. This method has been widely utilized across scientific domains, including public health where records from clinical, administrative, and other surveillance databases are aggregated and used for research, decision making, and assessment of public policies. When a common set of unique identifiers does not exist across sources, probabilistic linkage approaches are used to link records using a combination of attributes...
March 2018: IEEE Journal of Biomedical and Health Informatics
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