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https://www.readbyqxmd.com/read/28209304/prognostic-value-of-the-nutritional-risk-index-in-heart-transplant-recipients
#1
Eduardo Barge-Caballero, Fernando García-López, Raquel Marzoa-Rivas, Gonzalo Barge-Caballero, David Couto-Mallón, María J Paniagua-Martín, Miguel Solla-Buceta, Carlos Velasco-Sierra, Francisco Pita-Gutiérrez, José M Herrera-Noreña, José J Cuenca-Castillo, José Manuel Vázquez-Rodríguez, María G Crespo-Leiro
INTRODUCTION AND OBJECTIVES: To study the prognostic impact of preoperative nutritional status, as assessed through the nutritional risk index (NRI), on postoperative outcomes after heart transplantation (HT). METHODS: We conducted a retrospective, single-center study of 574 patients who underwent HT from 1991 to 2014. Preoperative NRI was calculated as 1.519 × serum albumin (g/L) + 41.7 × (body weight [kg] / ideal body weight [kg]). The association between preoperative NRI and postoperative outcomes was analyzed by means of multivariable logistic regression and multivariable Cox regression...
February 10, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28188315/how-in-office-and-ambulatory-bp-monitoring-compare-a-systematic-review-and-meta-analysis
#2
Sergio Reino-Gonzalez, Salvador Pita-Fernández, Teresa Seoane-Pillado, Beatriz López-Calviño, Sonia Pértega Díaz
Isolated office BP measurement is insufficient to confirm or rule out poorly controlled hypertension, and it increases the likelihood of under- or overestimating BP control.
January 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28185545/mirnatip-a-som-based-mirna-target-interactions-predictor
#3
Antonino Fiannaca, Massimo La Rosa, Laura La Paglia, Riccardo Rizzo, Alfonso Urso
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNA sequences with regulatory functions to post-transcriptional level for several biological processes, such as cell disease progression and metastasis. MiRNAs interact with target messenger RNA (mRNA) genes by base pairing. Experimental identification of miRNA target is one of the major challenges in cancer biology because miRNAs can act as tumour suppressors or oncogenes by targeting different type of targets. The use of machine learning methods for the prediction of the target genes is considered a valid support to investigate miRNA functions and to guide related wet-lab experiments...
September 22, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28168930/avirulence-avr-gene-based-diagnosis-complements-existing-pathogen-surveillance-tools-for-effective-deployment-of-resistance-r-genes-against-rice-blast-disease
#4
Shiela Marie Gines Selisana, Mary Jeanie Yanoria, Berlaine Quime, Chaivarakun Chaipanya, Guodong Lu, Rina Bagsic Opulencia, Guo-Liang Wang, Thomas Mitchell, James C Correll, Nick Talbot, Hei Leung, Bo Zhou
Avirulence genes in Magnaporthe oryzae, the fungal pathogen that causes the devastating rice blast disease, have been documented to be major targets subject to mutations to avoid recognition by resistance (R) genes. In this study, an avirulence (AVR) gene-based diagnosis tool for determining the virulence spectrum of a rice blast pathogen population was developed and validated. A set of 77 single-spore field isolates was subjected to pathotype analysis using differential lines each containing a single R gene and classified into 20 virulent pathotypes except for four isolates that lost pathogenicity...
February 7, 2017: Phytopathology
https://www.readbyqxmd.com/read/28158192/early-and-real-time-detection-of-seasonal-influenza-onset
#5
Miguel Won, Manuel Marques-Pita, Carlota Louro, Joana Gonçalves-Sá
Every year, influenza epidemics affect millions of people and place a strong burden on health care services. A timely knowledge of the onset of the epidemic could allow these services to prepare for the peak. We present a method that can reliably identify and signal the influenza outbreak. By combining official Influenza-Like Illness (ILI) incidence rates, searches for ILI-related terms on Google, and an on-call triage phone service, Saúde 24, we were able to identify the beginning of the flu season in 8 European countries, anticipating current official alerts by several weeks...
February 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28157106/disability-in-activities-of-daily-living-and%C3%A2-severity-of-dyskinesias-determine-the%C3%A2-handicap-of-parkinson-s-disease-patients-in%C3%A2-advanced-stage-selected-to-dbs
#6
Miguel Coelho, Daisy Abreu, Leonor Correia-Guedes, Patricia Pita Lobo, Margherita Fabbri, Catarina Godinho, Josefa Domingos, Luisa Albuquerque, Vanda Freitas, João Miguel Pereira, Begona Cattoni, Herculano Carvalho, Sofia Reimão, Mário M Rosa, António Gonalves Ferreira, Joaquim J Ferreira
BACKGROUND: There is scarce data on the level of handicap in Parkinson's disease (PD) and none in advanced stage PD. OBJECTIVE: To assess the handicap in advanced stage PD patients with disabling levodopa-induced motor complications selected to deep brain stimulation (DBS). METHODS: Data was prospectively recorded during routine evaluation for DBS. Handicap was measured using London Handicap Scale (LHS) (0 = maximal handicap; 1 = no handicap)...
January 30, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28156040/bioelectrochemical-haber-bosch-process-an-ammonia-producing-h2-n2-fuel-cell
#7
Ross D Milton, Rong Cai, Sofiene Abdellaoui, Dónal Leech, Antonio L De Lacey, Marcos Pita, Shelley D Minteer
Nitrogenases are the only enzymes known to reduce molecular nitrogen (N2 ) to ammonia (NH3 ). By using methyl viologen (N,N'-dimethyl-4,4'-bipyridinium) to shuttle electrons to nitrogenase, N2 reduction to NH3 can be mediated at an electrode surface. The coupling of this nitrogenase cathode with a bioanode that utilizes the enzyme hydrogenase to oxidize molecular hydrogen (H2 ) results in an enzymatic fuel cell (EFC) that is able to produce NH3 from H2 and N2 while simultaneously producing an electrical current...
February 3, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28126583/time-to-diagnosis-and-stage-of-symptomatic-colorectal-cancer-determined-by-three-different-sources-of-information-a-population-based-retrospective-study
#8
Alfonso Leiva, Magdalena Esteva, Joan Llobera, Francesc Macià, Salvador Pita-Fernández, Luis González-Luján, María A Sánchez-Calavera, María Ramos
BACKGROUND: Survival rates from colorectal cancer (CRC) are highly variable in Europe. This variability could potentially be explained by differences in healthcare system delays in diagnosis. However, even when such delays are reduced, the relationship of the diagnostic interval (time from presentation with symptoms to diagnosis) with outcome is uncertain. METHODS: A total of 795 patients with CRC from 5 regions of Spain were retrospectively examined in this population-based multicenter study...
January 23, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28113502/multimodal-stereoscopic-movie-summarization-conforming-to-narrative-characteristics
#9
Ioannis Mademlis, Anastasios Tefas, Nikos Nikolaidis, Ioannis Pitas
Video summarization is a timely and rapidly developing research field with broad commercial interest, due to the increasing availability of massive video data. Relevant algorithms face the challenge of needing to achieve a careful balance between summary compactness, enjoyability and content coverage. The specific case of stereoscopic 3D theatrical films has become more important over the past years, but not received corresponding research attention. In the present work, a multi-stage, multimodal summarization process for such stereoscopic movies is proposed, that is able to extract a short, representative video skim conforming to narrative characteristics from a 3D film...
October 5, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28106859/burkholderia-cepacia-complex-regulation-of-virulence-gene-expression-a-review
#10
REVIEW
Sílvia A Sousa, Joana R Feliciano, Tiago Pita, Soraia I Guerreiro, Jorge H Leitão
Burkholderia cepacia complex (Bcc) bacteria emerged as opportunistic pathogens in cystic fibrosis and immunocompromised patients. Their eradication is very difficult due to the high level of intrinsic resistance to clinically relevant antibiotics. Bcc bacteria have large and complex genomes, composed of two to four replicons, with variable numbers of insertion sequences. The complexity of Bcc genomes confers a high genomic plasticity to these bacteria, allowing their adaptation and survival to diverse habitats, including the human host...
January 19, 2017: Genes
https://www.readbyqxmd.com/read/28105566/phase-i-study-of-lurbinectedin-a-synthetic-tetrahydroisoquinoline-that-inhibits-activated-transcription-induces-dna-single-and-double-strand-breaks-on-a-weekly-%C3%A3-2-every-3-week-schedule
#11
Antonio Jimeno, Manish R Sharma, Sergio Szyldergemajn, Lia Gore, David Geary, Jennifer R Diamond, Carlos Fernandez Teruel, Arturo Soto Matos-Pita, Jorge Luis Iglesias, Martin Cullell-Young, Mark J Ratain
Background Lurbinectedin administered as a 1-h intravenous infusion every 3 weeks induces neutropenia, with the nadir usually occurring during the second week. This phase I study evaluated an alternative lurbinectedin dosing schedule consisting of a 1-h infusion on days 1 and 8 every 3 weeks. Patients and methods Twenty-one patients with advanced cancer received lurbinectedin using a standard cohort dose escalation design. Results Three dose levels of 3, 4, and 5 mg of lurbinectedin were explored. The recommended phase II dose was 5 mg, with 3 of 13 patients having dose-limiting toxicity (DLT), although grade 4 neutropenia occurred in 50% of patients...
January 20, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28101464/anti-inflammatory-and-antibothropic-properties-of-jatropha-elliptica-a-plant-from-brazilian-cerrado-biome
#12
Sára Cósta Ferreira-Rodrigues, Cássio Milhomens Rodrigues, Marcio Galdino Dos Santos, Jean Antonio Abraham Gautuz, Magali Glauzer Silva, José Carlos Cogo, Camila Batista-Silva, Cleiton Pita Dos Santos, Francisco Carlos Groppo, Karina Cogo-Müller, Yoko Oshima-Franco
Purpose: The aim of this study was to evaluate the antibothropic and anti-inflammatory properties of J. elliptica.Methods: Phytochemical screening and thin-layer chromatography (TLC) assays were performed on J. elliptica hydroalcoholic extract (TE) in order to observe its main constituents. The antibothropic activity of TE was evaluated by the in vitro neuromuscular blockade caused by Bothrops jararacussu venom (Bjssu), in a mouse phrenic nerve-diaphragm model (PND). A quantitative histological study was carried out to observe a possible protection of TE against the venom myotoxicity...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28094051/competition-policy-for-health-care-provision-in-portugal
#13
Pedro Pita Barros
We review the role of competition among healthcare providers in Portugal, which has a public National Health Service (NHS) at the core of the health system. There is little competition among healthcare providers within the NHS. Competition among NHS primary care providers is hindered by excess demand (many residents in Portugal do not have a designated family doctor). Competition among NHS hospitals has been traditionally limited to cases of maximum guaranteed waiting time for surgery being exceeded. The Portuguese Competition Authority enforces competition law...
February 2017: Health Policy
https://www.readbyqxmd.com/read/28086975/a-qualitative-study-of-women-s-and-health-providers-attitudes-and-acceptability-of-mistreatment-during-childbirth-in-health-facilities-in-guinea
#14
Mamadou Diouldé Balde, Abou Bangoura, Boubacar Alpha Diallo, Oumar Sall, Habibata Balde, Aïssatou Sona Niakate, Joshua P Vogel, Meghan A Bohren
BACKGROUND: Reducing maternal morbidity and mortality remains a key health challenge in Guinea. Anecdotal evidence suggests that women in Guinea are subjected to mistreatment during childbirth in health facilities, but limited research exists on this topic. This study was conducted to better understand the social norms and the acceptability of four scenarios of mistreatment during childbirth, from the perspectives of women and service providers. METHODS: This study used qualitative methods including in-depth interviews (IDIs) and focus group discussions (FGDs) with women of reproductive age, midwives, nurses and doctors...
January 13, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28079062/does-retinal-configuration-make-the-head-and-eyes-of-foveate-birds-move
#15
Bret A Moore, Luke P Tyrrell, Diana Pita, Olaf R P Bininda-Emonds, Esteban Fernández-Juricic
Animals move their heads and eyes to compensate for movements of the body and background, search, fixate, and track objects visually. Avian saccadic head/eye movements have been shown to vary considerably between species. We tested the hypothesis that the configuration of the retina (i.e., changes in retinal ganglion cell density from the retinal periphery to the center of acute vision-fovea) would account for the inter-specific variation in avian head/eye movement behavior. We characterized retinal configuration, head movement rate, and degree of eye movement of 29 bird species with a single fovea, controlling for the effects of phylogenetic relatedness...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077145/perceptions-and-experiences-of-the-mistreatment-of-women-during-childbirth-in-health-facilities-in-guinea-a-qualitative-study-with-women-and-service-providers
#16
Mamadou Diouldé Balde, Boubacar Alpha Diallo, Abou Bangoura, Oumar Sall, Anne Marie Soumah, Joshua P Vogel, Meghan A Bohren
BACKGROUND: Every woman is entitled to respectful care during childbirth; so it is concerning to hear of informal reports of mistreatment during childbirth in Guinea. This study sought to explore the perceptions and experiences of mistreatment during childbirth, from the perspectives of women and service providers, and the analysis presents findings according to a typology of mistreatment during childbirth. METHODS: This study used qualitative methods (in-depth interviews (IDIs) and focus group discussions (FGDs)) and was conducted with four groups of participants: women of reproductive age, midwives, doctors, and administrators...
January 11, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28076470/first-description-of-leishmania-viannia-infection-in-evandromyia-saulensis-pressatia-sp-and-trichophoromyia-auraensis-psychodidae-phlebotominae-in-a-transmission-area-of-cutaneous-leishmaniasis-in-acre-state-amazon-basin-brazil
#17
Thais de Araujo-Pereira, Daniela de Pita-Pereira, Mariana Côrtes Boité, Myllena Melo, Taiana Amancio da Costa-Rego, Andressa Alencastre Fuzari, Reginaldo Peçanha Brazil, Constança Britto
Studies on the sandfly fauna to evaluate natural infection indexes are still limited in the Brazilian Amazon, a region with an increasing incidence of cutaneous leishmaniasis. Here, by using a multiplex polymerase chain reaction directed to Leishmania kDNA and hybridisation, we were able to identify L. (Viannia) subgenus in 12 out of 173 sandflies captured in the municipality of Rio Branco, Acre state, revealing a positivity of 6.94%. By sequencing the Leishmania 234 bp-hsp70 amplified products from positive samples, infection by L...
January 1, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28055820/the-relationship-between-self-rated-health-and-use-of-parks-and-participation-in-recreation-programs-united-states-1991-and-2015
#18
Nicholas A D Pitas, Austin G Barrett, Andrew J Mowen, Alan R Graefe, Geoffrey C Godbey, Christopher N Sciamanna
We examined the relationship between self-rated health and use of parks and recreation program participation by using logistic regression to analyze data from representative national surveys conducted in 1991 and 2015. Neither park use nor program participation were significantly related to self-rated health in 1991; however, both were significantly related in 2015. The growing relationship between use of parks and recreation programs and self-rated health during this period is likely the result of broad national health promotion efforts and provides support for funding of capital and operational expenses for park and recreation services...
January 5, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28051308/analytical-methods-used-in-the-quality-control-of-honey
#19
Consuelo Pita-Calvo, María Esther Guerra-Rodríguez, Manuel Vázquez
Honey is a natural sweet substance produced by bees (Apis mellifera). In this work, the main parameters used in routine quality control of honey and the most commonly used analytical methods for their determination are reviewed. Honey can be adulterated with cheaper sweeteners or, indirectly, by feeding the bees with sugars. Therefore, methods for detecting and quantifying adulteration are necessary. Chromatographic techniques are widely used in honey analysis. More recently, techniques such as Raman, near-infrared, mid-infrared, and nuclear magnetic resonance spectroscopy in combination with chemometric data processing have been proposed...
February 1, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28028865/endemic-species-may-have-complex-histories-within-refugium-phylogeography-of-an-endangered-iberian-vole
#20
S Barbosa, J Paupério, J S Herman, C M Ferreira, R Pita, H M Vale-Gonçalves, J A Cabral, J A Garrido-García, R C Soriguer, P Beja, A Mira, P C Alves, J B Searle
Glacial refugia protected and promoted biodiversity during the Pleistocene, not only at a broader scale, but also for many endemics that contracted and expanded their ranges within refugial areas. Understanding the evolutionary history of refugial endemics is especially important in the case of endangered species to recognize the origins of their genetic structure and thus produce better informed conservation practices. The Iberian Peninsula is an important European glacial refugium, rich in endemics of conservation concern, including small mammals, such as the Cabrera vole (Microtus cabrerae)...
December 28, 2016: Molecular Ecology
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