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https://www.readbyqxmd.com/read/28319564/improvement-in-the-outcomes-of-meld-%C3%A2-40-liver-transplantation-an-analysis-of-207-consecutive-transplants-in-a-highly-competitive-dsa
#1
Victor Nekrasov, Lea Matsuoka, Navpreet Kaur, Alejandro Pita, Gilbert Whang, Shu Cao, Susan Groshen, Sophoclis Alexopoulos
BACKGROUND: Organ donor shortages continue to persist, especially in regions of the United States where competition is highest and recipients frequently attain a MELD score ≥ 40 prior to transplantation. The benefits of Share 35 in highly competitive regions may be underestimated when examining the collective national experience. The purpose of this study is to examine the outcomes of liver transplantation in recipients with a MELD ≥ 40 after implementation of Share 35 in a single center located in region 5...
March 18, 2017: Transplantation
https://www.readbyqxmd.com/read/28298225/exploring-public-sector-physicians-resilience-reactions-and-coping-strategies-in-times-of-economic-crisis-findings-from-a-survey-in-portugal-s-capital-city-area
#2
Giuliano Russo, Carlos André Pires, Julian Perelman, Luzia Gonçalves, Pedro Pita Barros
BACKGROUND: Evidence is accumulating on the impact of the recent economic crisis on health and health systems across Europe. However, little is known about the effect this is having on physicians - a crucial resource for the delivery of healthcare services. This paper explores the adaptation to the crisis of public sector physicians and their ability to keep performing their functions, with the objective of gaining a better understanding of health workers' resilience under deteriorating conditions...
March 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28270107/incidence-of-cardiovascular-events-and-associated-risk-factors-in-kidney-transplant-patients-a-competing-risks-survival-analysis
#3
María Teresa Seoane-Pillado, Salvador Pita-Fernández, Francisco Valdés-Cañedo, Rocio Seijo-Bestilleiro, Sonia Pértega-Díaz, Constantino Fernández-Rivera, Ángel Alonso-Hernández, Cristina González-Martín, Vanesa Balboa-Barreiro
BACKGROUND: The high prevalence of cardiovascular risk factors among the renal transplant population accounts for increased mortality. The aim of this study is to determine the incidence of cardiovascular events and factors associated with cardiovascular events in these patients. METHODS: An observational ambispective follow-up study of renal transplant recipients (n = 2029) in the health district of A Coruña (Spain) during the period 1981-2011 was completed...
March 7, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28260546/transposition-with-atypical-coronary-pattern-the-aubert-technique
#4
Ana Pita-Fernández, María T González-López, Juan M Gil-Jaurena
The arterial switch operation is currently the gold standard technique for repair of transposition of the great arteries. Some atypical coronary patterns such as intramural, interarterial, and a unique posterior button are associated with more complexity and surgical risk. We report a successful Aubert operation for transposition of the great arteries associated with a single and interarterial coronary artery arising from a posterior sinus.
March 6, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28259175/pleiotrophin-regulates-microglia-mediated-neuroinflammation
#5
Rosalía Fernández-Calle, Marta Vicente-Rodríguez, Esther Gramage, Jimena Pita, Carmen Pérez-García, Marcel Ferrer-Alcón, María Uribarri, María P Ramos, Gonzalo Herradón
BACKGROUND: Pleiotrophin (PTN) is a cytokine found highly upregulated in the brain in different disorders characterized by overt neuroinflammation such as neurodegenerative diseases, drug addiction, traumatic injury, and ischemia. In the present work, we have explored whether PTN modulates neuroinflammation and if Toll-like receptor 4 (TLR4), crucial in the initiation of an immune response, is involved. METHODS: In immunohistochemistry assays, we studied lipopolysaccharide (LPS, 7...
March 4, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28244794/utilidad-en-la-cl%C3%A3-nica-de-la-goma-guar-parcialmente-hidrolizada-revisi%C3%A3-n-de-la-evidencia-y-experiencia
#6
Ana Cantón Blanco, M ª Teresa Fernández López, Gloria Lugo Rodríguez, Miguel Á Martínez Olmos, Regina Palmeiro Carballeira, Francisco Pita Gutiérrez, Cristina Tejera Pérez
Introducción: la fibra dietética es un componente importante de la dieta humana. Cada tipo de fibra tiene efectos específicos a nivel metabólico y en el funcionamiento gastrointestinal, por lo que en cada patología concreta habremos de elegir la fibra óptima teniendo en cuenta sus propiedades químicas, físicas y fisiológicas.Objetivo: encuadrar la goma guar parcialmente hidrolizada en su lugar en el complejo marco de la fibra dietética, revisar sus propiedades físico-químicas y posibles mecanismos de acción; así como su potencial utilidad en distintas situaciones clínicas en pacientes adultos...
February 1, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28219631/condyle-excursion-angle-articular-eminence-inclination-and-temporomandibular-joint-morphologic-relations-with-disc-displacement
#7
Katharina Alves Rabelo, Saulo Leonardo Sousa Melo, Marianna Guanaes Gomes Torres, Paulo Sérgio F Campos, Patrícia Meira Bento, Daniela Pita de Melo
PURPOSE: The aim of this study was to evaluate the relations of the condyle excursion angle (CEA) and the morphology and morphometry of the articular eminence to disc displacement (DD) using magnetic resonance imaging (MRI) of symptomatic patients. MATERIALS AND METHODS: MRIs of 199 temporomandibular joints (TMJs) were evaluated. Qualitative and quantitative morphologic analyses were performed with tools available in PACS 11.0 (Carestream Health, Inc, Rochester, NY)...
January 29, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28209304/prognostic-value-of-the-nutritional-risk-index-in-heart-transplant-recipients
#8
Eduardo Barge-Caballero, Fernando García-López, Raquel Marzoa-Rivas, Gonzalo Barge-Caballero, David Couto-Mallón, María J Paniagua-Martín, Miguel Solla-Buceta, Carlos Velasco-Sierra, Francisco Pita-Gutiérrez, José M Herrera-Noreña, José J Cuenca-Castillo, José Manuel Vázquez-Rodríguez, María G Crespo-Leiro
INTRODUCTION AND OBJECTIVES: To study the prognostic impact of preoperative nutritional status, as assessed through the nutritional risk index (NRI), on postoperative outcomes after heart transplantation (HT). METHODS: We conducted a retrospective, single-center study of 574 patients who underwent HT from 1991 to 2014. Preoperative NRI was calculated as 1.519 × serum albumin (g/L) + 41.7 × (body weight [kg] / ideal body weight [kg]). The association between preoperative NRI and postoperative outcomes was analyzed by means of multivariable logistic regression and multivariable Cox regression...
February 10, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28188315/how-in-office-and-ambulatory-bp-monitoring-compare-a-systematic-review-and-meta-analysis
#9
Sergio Reino-Gonzalez, Salvador Pita-Fernández, Teresa Seoane-Pillado, Beatriz López-Calviño, Sonia Pértega Díaz
Isolated office BP measurement is insufficient to confirm or rule out poorly controlled hypertension, and it increases the likelihood of under- or overestimating BP control.
January 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28185545/mirnatip-a-som-based-mirna-target-interactions-predictor
#10
Antonino Fiannaca, Massimo La Rosa, Laura La Paglia, Riccardo Rizzo, Alfonso Urso
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNA sequences with regulatory functions to post-transcriptional level for several biological processes, such as cell disease progression and metastasis. MiRNAs interact with target messenger RNA (mRNA) genes by base pairing. Experimental identification of miRNA target is one of the major challenges in cancer biology because miRNAs can act as tumour suppressors or oncogenes by targeting different type of targets. The use of machine learning methods for the prediction of the target genes is considered a valid support to investigate miRNA functions and to guide related wet-lab experiments...
September 22, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28168930/avirulence-avr-gene-based-diagnosis-complements-existing-pathogen-surveillance-tools-for-effective-deployment-of-resistance-r-genes-against-rice-blast-disease
#11
Shiela Marie Gines Selisana, Mary Jeanie Yanoria, Berlaine Quime, Chaivarakun Chaipanya, Guodong Lu, Rina Bagsic Opulencia, Guo-Liang Wang, Thomas Mitchell, James C Correll, Nick Talbot, Hei Leung, Bo Zhou
Avirulence genes in Magnaporthe oryzae, the fungal pathogen that causes the devastating rice blast disease, have been documented to be major targets subject to mutations to avoid recognition by resistance (R) genes. In this study, an avirulence (AVR) gene-based diagnosis tool for determining the virulence spectrum of a rice blast pathogen population was developed and validated. A set of 77 single-spore field isolates was subjected to pathotype analysis using differential lines each containing a single R gene and classified into 20 virulent pathotypes except for four isolates that lost pathogenicity...
February 7, 2017: Phytopathology
https://www.readbyqxmd.com/read/28158192/early-and-real-time-detection-of-seasonal-influenza-onset
#12
Miguel Won, Manuel Marques-Pita, Carlota Louro, Joana Gonçalves-Sá
Every year, influenza epidemics affect millions of people and place a strong burden on health care services. A timely knowledge of the onset of the epidemic could allow these services to prepare for the peak. We present a method that can reliably identify and signal the influenza outbreak. By combining official Influenza-Like Illness (ILI) incidence rates, searches for ILI-related terms on Google, and an on-call triage phone service, Saúde 24, we were able to identify the beginning of the flu season in 8 European countries, anticipating current official alerts by several weeks...
February 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28157106/disability-in-activities-of-daily-living-and%C3%A2-severity-of-dyskinesias-determine-the%C3%A2-handicap-of-parkinson-s-disease-patients-in%C3%A2-advanced-stage-selected-to-dbs
#13
Miguel Coelho, Daisy Abreu, Leonor Correia-Guedes, Patricia Pita Lobo, Margherita Fabbri, Catarina Godinho, Josefa Domingos, Luisa Albuquerque, Vanda Freitas, João Miguel Pereira, Begona Cattoni, Herculano Carvalho, Sofia Reimão, Mário M Rosa, António Gonalves Ferreira, Joaquim J Ferreira
BACKGROUND: There is scarce data on the level of handicap in Parkinson's disease (PD) and none in advanced stage PD. OBJECTIVE: To assess the handicap in advanced stage PD patients with disabling levodopa-induced motor complications selected to deep brain stimulation (DBS). METHODS: Data was prospectively recorded during routine evaluation for DBS. Handicap was measured using London Handicap Scale (LHS) (0 = maximal handicap; 1 = no handicap)...
January 30, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28156040/bioelectrochemical-haber-bosch-process-an-ammonia-producing-h2-n2-fuel-cell
#14
Ross D Milton, Rong Cai, Sofiene Abdellaoui, Dónal Leech, Antonio L De Lacey, Marcos Pita, Shelley D Minteer
Nitrogenases are the only enzymes known to reduce molecular nitrogen (N2 ) to ammonia (NH3 ). By using methyl viologen (N,N'-dimethyl-4,4'-bipyridinium) to shuttle electrons to nitrogenase, N2 reduction to NH3 can be mediated at an electrode surface. The coupling of this nitrogenase cathode with a bioanode that utilizes the enzyme hydrogenase to oxidize molecular hydrogen (H2 ) results in an enzymatic fuel cell (EFC) that is able to produce NH3 from H2 and N2 while simultaneously producing an electrical current...
March 1, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28126583/time-to-diagnosis-and-stage-of-symptomatic-colorectal-cancer-determined-by-three-different-sources-of-information-a-population-based-retrospective-study
#15
Alfonso Leiva, Magdalena Esteva, Joan Llobera, Francesc Macià, Salvador Pita-Fernández, Luis González-Luján, María A Sánchez-Calavera, María Ramos
BACKGROUND: Survival rates from colorectal cancer (CRC) are highly variable in Europe. This variability could potentially be explained by differences in healthcare system delays in diagnosis. However, even when such delays are reduced, the relationship of the diagnostic interval (time from presentation with symptoms to diagnosis) with outcome is uncertain. METHODS: A total of 795 patients with CRC from 5 regions of Spain were retrospectively examined in this population-based multicenter study...
January 23, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28113502/multimodal-stereoscopic-movie-summarization-conforming-to-narrative-characteristics
#16
Ioannis Mademlis, Anastasios Tefas, Nikos Nikolaidis, Ioannis Pitas
Video summarization is a timely and rapidly developing research field with broad commercial interest, due to the increasing availability of massive video data. Relevant algorithms face the challenge of needing to achieve a careful balance between summary compactness, enjoyability and content coverage. The specific case of stereoscopic 3D theatrical films has become more important over the past years, but not received corresponding research attention. In the present work, a multi-stage, multimodal summarization process for such stereoscopic movies is proposed, that is able to extract a short, representative video skim conforming to narrative characteristics from a 3D film...
October 5, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28106859/burkholderia-cepacia-complex-regulation-of-virulence-gene-expression-a-review
#17
REVIEW
Sílvia A Sousa, Joana R Feliciano, Tiago Pita, Soraia I Guerreiro, Jorge H Leitão
Burkholderia cepacia complex (Bcc) bacteria emerged as opportunistic pathogens in cystic fibrosis and immunocompromised patients. Their eradication is very difficult due to the high level of intrinsic resistance to clinically relevant antibiotics. Bcc bacteria have large and complex genomes, composed of two to four replicons, with variable numbers of insertion sequences. The complexity of Bcc genomes confers a high genomic plasticity to these bacteria, allowing their adaptation and survival to diverse habitats, including the human host...
January 19, 2017: Genes
https://www.readbyqxmd.com/read/28105566/phase-i-study-of-lurbinectedin-a-synthetic-tetrahydroisoquinoline-that-inhibits-activated-transcription-induces-dna-single-and-double-strand-breaks-on-a-weekly-%C3%A3-2-every-3-week-schedule
#18
Antonio Jimeno, Manish R Sharma, Sergio Szyldergemajn, Lia Gore, David Geary, Jennifer R Diamond, Carlos Fernandez Teruel, Arturo Soto Matos-Pita, Jorge Luis Iglesias, Martin Cullell-Young, Mark J Ratain
Background Lurbinectedin administered as a 1-h intravenous infusion every 3 weeks induces neutropenia, with the nadir usually occurring during the second week. This phase I study evaluated an alternative lurbinectedin dosing schedule consisting of a 1-h infusion on days 1 and 8 every 3 weeks. Patients and methods Twenty-one patients with advanced cancer received lurbinectedin using a standard cohort dose escalation design. Results Three dose levels of 3, 4, and 5 mg of lurbinectedin were explored. The recommended phase II dose was 5 mg, with 3 of 13 patients having dose-limiting toxicity (DLT), although grade 4 neutropenia occurred in 50% of patients...
January 20, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28101464/anti-inflammatory-and-antibothropic-properties-of-jatropha-elliptica-a-plant-from-brazilian-cerrado-biome
#19
Sára Cósta Ferreira-Rodrigues, Cássio Milhomens Rodrigues, Marcio Galdino Dos Santos, Jean Antonio Abraham Gautuz, Magali Glauzer Silva, José Carlos Cogo, Camila Batista-Silva, Cleiton Pita Dos Santos, Francisco Carlos Groppo, Karina Cogo-Müller, Yoko Oshima-Franco
Purpose: The aim of this study was to evaluate the antibothropic and anti-inflammatory properties of J. elliptica.Methods: Phytochemical screening and thin-layer chromatography (TLC) assays were performed on J. elliptica hydroalcoholic extract (TE) in order to observe its main constituents. The antibothropic activity of TE was evaluated by the in vitro neuromuscular blockade caused by Bothrops jararacussu venom (Bjssu), in a mouse phrenic nerve-diaphragm model (PND). A quantitative histological study was carried out to observe a possible protection of TE against the venom myotoxicity...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28094051/competition-policy-for-health-care-provision-in-portugal
#20
Pedro Pita Barros
We review the role of competition among healthcare providers in Portugal, which has a public National Health Service (NHS) at the core of the health system. There is little competition among healthcare providers within the NHS. Competition among NHS primary care providers is hindered by excess demand (many residents in Portugal do not have a designated family doctor). Competition among NHS hospitals has been traditionally limited to cases of maximum guaranteed waiting time for surgery being exceeded. The Portuguese Competition Authority enforces competition law...
February 2017: Health Policy
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