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https://www.readbyqxmd.com/read/29045483/lipid-profile-cardiovascular-disease-and-mortality-in-a-mediterranean-high-risk-population-the-escarval-risk-study
#1
Domingo Orozco-Beltran, Vicente F Gil-Guillen, Josep Redon, Jose M Martin-Moreno, Vicente Pallares-Carratala, Jorge Navarro-Perez, Francisco Valls-Roca, Carlos Sanchis-Domenech, Antonio Fernandez-Gimenez, Ana Perez-Navarro, Vicente Bertomeu-Martinez, Vicente Bertomeu-Gonzalez, Alberto Cordero, Manuel Pascual de la Torre, Jose L Trillo, Concepcion Carratala-Munuera, Salvador Pita-Fernandez, Ruth Uso, Ramon Durazo-Arvizu, Richard Cooper, Gines Sanz, Jose M Castellano, Juan F Ascaso, Rafael Carmena, Maria Tellez-Plaza
INTRODUCTION: The potential impact of targeting different components of an adverse lipid profile in populations with multiple cardiovascular risk factors is not completely clear. This study aims to assess the association between different components of the standard lipid profile with all-cause mortality and hospitalization due to cardiovascular events in a high-risk population. METHODS: This prospective registry included high risk adults over 30 years old free of cardiovascular disease (2008-2012)...
2017: PloS One
https://www.readbyqxmd.com/read/29040812/a-randomized-controlled-cross-over-study-of-appetite-related-sensations-after-consuming-snacks-made-from-buckwheat
#2
Danielle M Defries, Jay C Petkau, Terri Gregor, Heather Blewett
With the rising incidence of overweight and obesity in developed countries, there is an interest in developing food products that may aid in satiety and reduce energy intake. Buckwheat is a gluten-free edible seed that has been previously shown to induce changes in post-prandial concentrations of satiety hormones; however, subjective measures of appetite-related sensations and objective measures of energy intake at subsequent meals following buckwheat consumption have not been measured. Thirty eight healthy adults were recruited to participate in a randomized, controlled, cross-over trial with the main objective to determine if consuming snacks made from buckwheat would increase satiety and reduce energy intake compared to snacks comparable in serving size, physical characteristics, and nutrient composition...
October 17, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29040781/further-insights-into-the-components-of-resistance-to-ophiostoma-novo-ulmi-in-ulmus-minor-hydraulic-conductance-stomatal-sensitivity-and-bark-dehydration
#3
Pilar Pita, Jesús Rodríguez-Calcerrada, David Medel, Luis Gil
Dutch elm disease (DED) is a vascular disease that has killed over 1 billion elm trees. The pathogen spreads throughout the xylem network triggering vessel blockage, which results in water stress, tissue dehydration and extensive leaf wilting in susceptible genotypes. We investigated the differences between four Ulmus minor Mill. clones of contrasting susceptibility to Ophiostoma novo-ulmi Brasier regarding morphological, anatomical and physiological traits affecting water transport, in order to gain a better understanding of the mechanisms underlying DED susceptibility...
October 13, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29023453/plant-water-potential-improves-prediction-of-empirical-stomatal-models
#4
William R L Anderegg, Adam Wolf, Adriana Arango-Velez, Brendan Choat, Daniel J Chmura, Steven Jansen, Thomas Kolb, Shan Li, Frederick Meinzer, Pilar Pita, Víctor Resco de Dios, John S Sperry, Brett T Wolfe, Stephen Pacala
Climate change is expected to lead to increases in drought frequency and severity, with deleterious effects on many ecosystems. Stomatal responses to changing environmental conditions form the backbone of all ecosystem models, but are based on empirical relationships and are not well-tested during drought conditions. Here, we use a dataset of 34 woody plant species spanning global forest biomes to examine the effect of leaf water potential on stomatal conductance and test the predictive accuracy of three major stomatal models and a recently proposed model...
2017: PloS One
https://www.readbyqxmd.com/read/29021147/atypical-haematological-presentation-in-a-case-of-polycythaemia-vera-with-a-new-variant-mutation-detected-in-exon-12-c-1605g-t-p-met535ile
#5
Amélia Soraia Andrade Pita, Ana Paula da Silva Azevedo, Alice Reichert, Cândido José Pimenta da Silva, Vanessa Henriques, Diana Sousa Mendes, Ana Maria Batalha Reis, Rita Cerqueira, Fátima Torres, João Faro Viana
One of the major genetic insights into the pathogenesis of polycythaemia vera included the identification of the somatic point gain-of-function mutations in Janus kinase 2 gene-first JAK2V617F on exon 14, present in 95%-97% of the cases, and later on exon 12. In the literature, we can find some reported studies where different exon 12 mutations are identified. Unlike patients with JAK2V617F mutation in exon 14, the mutation at exon 12 is not usually associated with an increase in the three haematopoietic series (erythrocytosis, leucocytosis and thrombocytosis)...
October 11, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28989902/quantitative-assessment-of-image-artifacts-from-root-filling-materials-on-cbct-scans-made-using-several-exposure-parameters
#6
Katharina Alves Rabelo, Yuri Wanderley Cavalcanti, Martina Gerlane de Oliveira Pinto, Saulo Leonardo Sousa Melo, Paulo Sérgio Flores Campos, Luciana Soares de Andrade Freitas Oliveira, Daniela Pita de Melo
PURPOSE: To quantify artifacts from different root filling materials in cone-beam computed tomography (CBCT) images acquired using different exposure parameters. MATERIALS AND METHODS: Fifteen single-rooted teeth were scanned using 8 different exposure protocols with 3 different filling materials and once without filling material as a control group. Artifact quantification was performed by a trained observer who made measurements in the central axial slice of all acquired images in a fixed region of interest using ImageJ...
September 2017: Imaging Science in Dentistry
https://www.readbyqxmd.com/read/28983868/the-race-structure-of-the-rice-blast-pathogen-across-southern-and-northeastern-china
#7
Yaling Zhang, Qiongle Zhu, Yongxiang Yao, Zhenghong Zhao, James C Correll, Ling Wang, Qinghua Pan
BACKGROUND: Rice blast, caused by the ascomycete Magnaporthe oryzae (Mo), imposes a major constraint on rice productivity. Managing the disease through the deployment of host resistance requires a close understanding of race structure of the pathogen population. RESULTS: The host/pathogen interaction between isolates sampled from four Mo populations collected across the rice-producing regions of China was tested using two established panels of differential cultivars...
October 5, 2017: Rice
https://www.readbyqxmd.com/read/28975410/halides-inhibition-of-multicopper-oxidases-studied-by-ftir-spectroelectrochemistry-using-azide-as-an-active-infrared-probe
#8
Chiara Di Bari, Nicolas Mano, Sergey Shleev, Marcos Pita, Antonio L De Lacey
An infrared spectroelectrochemical study of Trametes hirsuta laccase and Magnaporthe oryzae bilirubin oxidase has been performed using azide, an inhibitor of multicopper oxidases, as an active infrared probe incorporated into the T2/T3 copper cluster of the enzymes. The redox potential-controlled measurements indicate that N3(-) stretching IR bands of azide ion bound to the T2/T3 cluster are only detected for the oxidized enzymes, confirming that azide only binds to Cu(2+). Moreover, the process of binding/dissociation of azide ion is shown to be reversible...
October 3, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28961837/antitumor-activity-of-lurbinectedin-pm01183-and-doxorubicin-in-relapsed-small-cell-lung-cancer-results-from-a-phase-i-study
#9
E Calvo, V Moreno, M Flynn, E Holgado, M E Olmedo, M P Lopez Criado, C Kahatt, J A Lopez-Vilariño, M Siguero, C Fernandez-Teruel, M Cullell-Young, A Soto Matos-Pita, M Forster
Background: Lurbinectedin (PM01183) has synergistic antitumor activity when combined with doxorubicin in mice with xenografted tumors. This phase I trial determined the recommended dose (RD) of doxorubicin (bolus) and PM01183 (1-h intravenous infusion) on day 1 every 3 weeks (q3wk), and obtained preliminary evidence of antitumor activity for this combination in small-cell lung cancer (SCLC). Patients and methods: Patients with advanced solid tumors received doxorubicin and PM01183 following a standard dose escalation design and expansion at the RD...
October 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28961156/exome-array-analysis-identifies-gpr35-as-a-novel-susceptibility-gene-for-anthracycline-induced-cardiotoxicity-in-childhood-cancer
#10
Sara Ruiz-Pinto, Guillermo Pita, Ana Patiño-García, Javier Alonso, Antonio Pérez-Martínez, Antonio J Cartón, Federico Gutiérrez-Larraya, María R Alonso, Daniel R Barnes, Joe Dennis, Kyriaki Michailidou, Carmen Gómez-Santos, Deborah J Thompson, Douglas F Easton, Javier Benítez, Anna González-Neira
OBJECTIVES: Pediatric cancer survivors are a steadily growing population; however, chronic anthracycline-induced cardiotoxicity (AIC) is a serious long-term complication leading to considerable morbidity. We aimed to identify new genes and low-frequency variants influencing the susceptibility to AIC for pediatric cancer patients. PATIENTS AND METHODS: We studied the association of variants on the Illumina HumanExome BeadChip array in 83 anthracycline-treated pediatric cancer patients...
September 27, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28956109/hallux-valgus-in-a-random-population-in-spain-and-its-impact-on-quality-of-life-and-functionality
#11
Cristina González-Martín, Francisco Alonso-Tajes, Sergio Pérez-García, María Teresa Seoane-Pillado, Sonia Pértega-Díaz, Estefanía Couceiro-Sánchez, Rocío Seijo-Bestilleiro, Salvador Pita-Fernández
The aim of this study was to determine the prevalence of Hallux valgus (HV) and the association between the presence thereof and quality of life, dependence for basic and instrumental activities of daily living and foot function. Prevalence study was carried out in a random population sample (n = 1837) (α = 0.05; Precision = ±2.2%). Informed consent and ethical review board were obtained (code 2008/264). We studied anthropometric variables, Charlson Comorbidity Index, function and state of foot [Foot Function index (FFI), Foot Health Status Questionnaire (FHSQ)], quality of life (SF-36), and dependence for activities of daily living (Barthel and Lawton index)...
November 2017: Rheumatology International
https://www.readbyqxmd.com/read/28954390/brown-algae-padina-sanctae-crucis-b%C3%A3-rgesen-a-potential-nutraceutical
#12
Raquel B S S Nogueira, Anna Cláudia A Tomaz, Déborah R Pessoa, Aline L Xavier, João Carlos L R Pita, Marianna V Sobral, Marcela L C Pontes, Hilzeth L F Pessôa, Margareth F F M Diniz, George Emmanuel C Miranda, Maria Aparecida R Vieira, Marcia O M Marques, Maria de Fátima V Souza, Emídio V L Cunha
Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and hidroxy-phaeophytin new for the family Dictyotaceae, and; mannitol first described in this species. Saturated fatty acids as compared to the percentages of unsaturated fatty acids were shown to be present in greater abundance...
September 26, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28928862/discovering-the-mir-26a-5p-targetome-in-prostate-cancer-cells
#13
Milena Rizzo, Gabriele Berti, Francesco Russo, Sofia Fazio, Monica Evangelista, Romina D'Aurizio, Marco Pellegrini, Giuseppe Rainaldi
Purpose. miR-26a-5p is a tumor suppressor (TS) miRNA often downregulated in several tumor tissues and tumor cell lines. In this work, we performed the re-expression of the miR-26a-5p in DU-145 prostate cancer cells to collect genes interacting with miR-26a-5p and analyzed their integration in the tumorigenesis related pathways. Methods. The transfection of DU-145 prostate cancer cells with miR-26a-5p was done using nucleofection. The biological effects induced by miR-26a-5p re-expression were detected with routine assays for cell proliferation, cell cycle, survival, apoptosis and cell migration...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28922025/prevalence-of-staphylococcal-enterotoxins-in-ready-to-eat-foods-sold-in-istanbul
#14
Beyza H Ulusoy, Burcu Çakmak Sancar, Muhsin Öztürk
The aim of this study was to investigate the prevalence of staphylococcal enterotoxins (SEs) in ready-to-eat (RTE) foods sold in Istanbul, Turkey. A total of 5,241 samples were randomly collected from various caterers, hotels, and restaurants from 2014 to 2016. The samples were classified into four groups: (i) various cooked RTE meat and vegetable meals, (ii) various RTE salads, charcuterie, and cold appetizers, (iii) various cooked RTE bakery products (pasta, pastries, pizza, pita, ravioli, etc.), and (iv) any cooked RTE sweets and desserts (pudding, custard, cream, ashura, etc...
October 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28914371/serum-cystatin-c-is-associated-with-kidney-function-but-not-with-cardiovascular-risk-factors-or-subclinical-atherosclerosis-in-patients-with-systemic-lupus-erythematosus
#15
Patricia Garcia-Garcia, Raquel Castejon, Pablo Tutor-Ureta, R A Silvestre, Susana Mellor-Pita, Carlos Jimenez-Ortiz, Miguel Yebra-Bango
Cystatin C (CysC) is a protein considered as an excellent marker of renal function, and it has been suggested as an independent predictor of cardiovascular (CV) risk. We evaluated the association of serum CysC with renal function, CV risk factors, inflammation, and subclinical atherosclerosis in Systemic Lupus Erythematosus (SLE) patients. Sixty-one SLE female patients were selected according to estimated glomerular filtration rate (GFR) > 60 ml/min/1.73m(2). Renal function parameters, SLE specific factors, CV risk factors, and inflammatory markers were assessed...
September 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28913729/exome-array-analysis-identifies-etfb-as-a-novel-susceptibility-gene-for-anthracycline-induced-cardiotoxicity-in-cancer-patients
#16
Sara Ruiz-Pinto, Guillermo Pita, Miguel Martín, Teresa Alonso-Gordoa, Daniel R Barnes, María R Alonso, Belén Herraez, Purificación García-Miguel, Javier Alonso, Antonio Pérez-Martínez, Antonio J Cartón, Federico Gutiérrez-Larraya, José A García-Sáenz, Javier Benítez, Douglas F Easton, Ana Patiño-García, Anna González-Neira
PURPOSE: Anthracyclines are widely used chemotherapeutic drugs that can cause progressive and irreversible cardiac damage and fatal heart failure. Several genetic variants associated with anthracycline-induced cardiotoxicity (AIC) have been identified, but they explain only a small proportion of the interindividual differences in AIC susceptibility. METHODS: In this study, we evaluated the association of low-frequency variants with risk of chronic AIC using the Illumina HumanExome BeadChip array in a discovery cohort of 61 anthracycline-treated breast cancer patients with replication in a second independent cohort of 83 anthracycline-treated pediatric cancer patients, using gene-based tests (SKAT-O)...
September 14, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28874168/holocentric-chromosome-evolution-in-kissing-bugs-hemiptera-reduviidae-triatominae-diversification-of-repeated-sequences
#17
Sebastián Pita, Pedro Lorite, Jesús Vela, Pablo Mora, Teresa Palomeque, Khoa Pham Thi, Francisco Panzera
BACKGROUND: The analysis of the chromosomal and genome evolution in organisms with holocentric chromosomes is restricted by the lack of primary constriction or centromere. An interesting group is the hemipteran subfamily Triatominae, vectors of Chagas disease, which affects around 6 to 7 million people worldwide. This group exhibits extensive variability in the number and chromosomal location of repeated sequences such as heterochromatin and ribosomal genes. This paper tries to reveal the significant differences of the repeated sequences among Triatoma species through the use of genomic DNA probes...
September 6, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28861219/disentangling-the-genetic-and-morphological-structure-of-patella-candei-complex-in-macaronesia-ne-atlantic
#18
Joao Faria, Gustavo M Martins, Alfonso Pita, Pedro A Ribeiro, Stephen J Hawkins, Pablo Presa, Ana I Neto
The uptake of natural living resources for human consumption has triggered serious changes in the balance of ecosystems. In the archipelagos of Macaronesia (NE Atlantic), limpets have been extensively exploited probably since islands were first colonized. This has led to profound consequences in the dynamics of rocky shore communities. The Patella candei complex includes various subspecies of limpets that are ascribed to a particular archipelago and has been the focus of several taxonomic surveys without much agreement...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28812976/learning-and-recognition-of-tactile-temporal-sequences-by-mice-and-humans
#19
Michael R Bale, Malamati Bitzidou, Anna Pitas, Leonie S Brebner, Lina Khazim, Stavros T Anagnou, Caitlin D Stevenson, Miguel Maravall
The world around us is replete with stimuli that unfold over time. When we hear an auditory stream like music or speech or scan a texture with our fingertip, physical features in the stimulus are concatenated in a particular order. This temporal patterning is critical to interpreting the stimulus. To explore the capacity of mice and humans to learn tactile sequences, we developed a task in which subjects had to recognise a continuous modulated noise sequence delivered to whiskers or fingertips, defined by its temporal patterning over hundreds of milliseconds...
August 16, 2017: ELife
https://www.readbyqxmd.com/read/28796195/energy-transfer-efficiency-from-zno-nanocrystals-to-eu-3-ions-embedded-in-sio%C3%A2-film-for-emission-at-614-nm
#20
Vivek Mangalam, Kantisara Pita
In this work, we study the energy transfer mechanism from ZnO nanocrystals (ZnO-nc) to Eu(3+) ions by fabricating thin-film samples of ZnO-nc and Eu(3+) ions embedded in a SiO₂ matrix using the low-cost sol-gel technique. The time-resolved photoluminescence (TRPL) measurements from the samples were analyzed to understand the contribution of energy transfer from the various ZnO-nc emission centers to Eu(3+) ions. The decay time obtained from the TRPL measurements was used to calculate the energy transfer efficiencies from the ZnO-nc emission centers, and these results were compared with the energy transfer efficiencies calculated from steady-state photoluminescence emission results...
August 10, 2017: Materials
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