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https://www.readbyqxmd.com/read/29349920/hyperuricemia-in-asian-psoriatic-arthritis-patients
#1
Tin Lok Lai, Cheuk Wan Yim, Pui Yan Wong, Man Chi Leung, Woon Leung Ng
AIM: It is generally accepted that hyperuricemia is commonly associated with psoriatic arthritis (PsA). However, variations in ethnicity, diet and habitat may contribute to differences in prevalence and risk factors for hyperuricemia in PsA patients. Moreover, Asian specific data is deficient. The primary objective of the present study was to determine the prevalence of hyperuricemia among PsA patients. The secondary objective was to explore its associated risk factors. METHODS: This was a multi-center, cross-sectional observational study of 160 PsA patients from local Rheumatology clinics...
January 18, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29346138/obesity-and-chronic-kidney-disease
#2
Edward Nehus
PURPOSE OF REVIEW: To review recent advances in the epidemiology, pathophysiology, clinical features, and treatment of obesity-related kidney disease. RECENT FINDINGS: Studies have confirmed that obesity is associated with increased risk of developing chronic kidney disease (CKD). This risk extends to those who are metabolically healthy, indicating that obesity per se contributes to CKD independent of the metabolic syndrome. Recent developments in the pathophysiology of obesity-related kidney disease indicate that chronic inflammation and abnormal lipid metabolism contribute to kidney cell injury...
January 17, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29343817/associations-between-body-mass-index-and-the-risk-of-renal-events-in-patients-with-type-2-diabetes
#3
Kamel Mohammedi, John Chalmers, William Herrington, Qiang Li, Giuseppe Mancia, Michel Marre, Neil Poulter, Anthony Rodgers, Bryan Williams, Vlado Perkovic, Josef Coresh, Mark Woodward
BACKGROUND/OBJECTIVES: We aimed to evaluate the relationship between BMI and the risk of renal disease in patients with type 2 diabetes in the Action in Diabetes and Vascular Disease: PreterAx and DiamicroN Modified-Release Controlled Evaluation (ADVANCE) study. SUBJECTS/METHODS: Participants were divided into six baseline BMI categories: <18.5 (underweight, n = 58); ≥18.5 to <25 (normal, n = 2894); ≥25 to <30 (overweight, n = 4340); ≥30 to <35 (obesity grade 1, n = 2265); ≥35 to <40 (obesity grade 2, n = 744); and ≥40 kg/m2 (obesity grade 3, n = 294); those underweight were excluded...
January 17, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29340699/long-term-expression-of-glomerular-genes-in-diabetic-nephropathy
#4
Dominik Chittka, Bernhard Banas, Laura Lennartz, Franz Josef Putz, Kathrin Eidenschink, Sebastian Beck, Thomas Stempfl, Christoph Moehle, Simone Reichelt-Wurm, Miriam C Banas
Background: Although diabetic nephropathy (DN) is the most common cause for end-stage renal disease in western societies, its pathogenesis still remains largely unclear. A different gene pattern of diabetic and healthy kidney cells is one of the probable explanations. Numerous signalling pathways have emerged as important pathophysiological mechanisms for diabetes-induced renal injury. Methods: Glomerular cells, as podocytes or mesangial cells, are predominantly involved in the development of diabetic renal lesions...
January 11, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29340529/association-between-syndecan-1-and-renal-function-in-adolescents-with-excess-weight-evidence-of-subclinical-kidney-disease-and-endothelial-dysfunction
#5
Z M R M Saboia, G C Meneses, A M C Martins, E F Daher, G B Silva Junior
Excess weight (overweight and obesity) is associated with kidney and cardiovascular disease. The aim of this study was to investigate the association between syndecan-1 and renal function among adolescents with excess weight. A total of 56 students from a public school at Fortaleza, CE, Brazil, were investigated. The adolescents were submitted to anthropometric evaluation, including weight, height, blood pressure and body mass index. Blood and urine samples were collected for the determination of serum lipids (total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglycerides), and the endothelial injury biomarker syndecan-1...
January 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29339048/intrarenal-fat-deposition-does-not-interfere-with-the-measurement-of-single-kidney-perfusion-in-obese-swine-using-multi-detector-computed-tomography
#6
Christopher M Ferguson, Alfonso Eirin, Gregory J Michalak, Ahmad F Hedayat, Abdelrhman Abumoawad, Ahmed Saad, Xiangyang Zhu, Stephen C Textor, Cynthia H McCollough, Lilach O Lerman
BACKGROUND: Altered vascular structure or function in several diseases may impair renal perfusion. Multi-detector computed tomography (MDCT) is a non-invasive tool to assess single-kidney perfusion and function based on dynamic changes in tissue attenuation during contrast media transit. However, changes in basal tissue attenuation might hamper these assessments, despite background subtraction. Evaluation of iodine concentration using the dual-energy (DECT) MDCT mode allows excluding effects of basal values on dynamic changes in tissue attenuation...
January 10, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29333506/murine-models-of-heart-failure-with-preserved-ejection-fraction-a-fishing-expedition
#7
Maria Valero-Muñoz, Warren Backman, Flora Sam
Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and symptoms of HF in the presence of a normal left ventricular (LV) ejection fraction (EF). Despite accounting for up to 50% of all clinical presentations of HF, the mechanisms implicated in HFpEF are poorly understood, thus precluding effective therapy. The pathophysiological heterogeneity in the HFpEF phenotype also contributes to this disease and likely to the absence of evidence-based therapies. Limited access to human samples and imperfect animal models that completely recapitulate the human HFpEF phenotype have impeded our understanding of the mechanistic underpinnings that exist in this disease...
December 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/29333144/did-creatinine-standardization-give-benefits-to-the-evaluation-of-glomerular-filtration-rate
#8
Laurence Piéroni, Anne-Sophie Bargnoux, Jean-Paul Cristol, Etienne Cavalier, Pierre Delanaye
During the last decade, a lot of efforts has been made to improve the evaluation of renal functions. Measured Glomerular Filtration Rate (GFR) remains the only valuable test to confirm or confute the status of chronic kidney disease (CKD) and is recommended by Kidney Disease Global Outcomes guidelines when estimation of GFR is not reliable. However, in routine clinical practice, serum creatinine remains the one of the most prescribed biological parameters and is an undeniable factor, alone or in association with other parameters, of the estimation of GFR...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29328026/clinical-efficacy-of-s-adenosylmethionine-in-patients-with-non-alcoholic-steatohepatitis-and-chronic-kidney-disease-i-ii-stage
#9
A Antoniv, N Antofiychuk, T Danylyshina, I Trefanenko, V Shuper
The article presents a theoretical generalization of the results of the clinical efficacy of S-adenosylmethionine in patients with non-alcoholic steatohepatitis (NASH) in comorbidity with obesity and chronic kidney disease (CKD) of the 1st-2nd stages. The objective of the article was to determine the likely effect of S-adenosylmethionine and Meldonium on the clinical course of non-alcoholic steatohepatitis (NASH) and chronic kidney disease (CKD) of the I-II stages. We examined 75 patients with NASH with comorbid obesity I degree and CKD I and II dgrees...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29324650/update-on-the-impact-of-omega-3-fatty-acids-on-inflammation-insulin-resistance-and-sarcopenia-a-review
#10
REVIEW
Alex Buoite Stella, Gianluca Gortan Cappellari, Rocco Barazzoni, Michela Zanetti
Elderly and patients affected by chronic diseases face a high risk of muscle loss and impaired physical function. Omega 3 fatty acids (FA) attenuate inflammation and age-associated muscle loss, prevent systemic insulin resistance and improve plasma lipids, potentially impacting on sarcopenia. This paper aims to review recent randomized clinical studies assessing the effects a chronic omega 3 FA supplementation on inflammatory and metabolic profile during conditions characterized by sarcopenia (aging, insulin resistance, type 2 diabetes, chronic renal failure)...
January 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29321950/manifestations-of-renal-impairment-in-fructose-induced-metabolic-syndrome
#11
Kameliya Bratoeva, George S Stoyanov, Albena Merdzhanova, Mariya Radanova
Introduction International studies show an increased incidence of chronic kidney disease (CKD) in patients with metabolic syndrome (MS). It is assumed that the major components of MS - obesity, insulin resistance, dyslipidemia, and hypertension - are linked to renal damage through the systemic release of several pro-inflammatory mediators, such as uric acid (UA), C-reactive protein (CRP), and generalized oxidative stress. The aim of the present study was to investigate the extent of kidney impairment and manifestations of dysfunction in rats with fructose-induced MS...
November 7, 2017: Curēus
https://www.readbyqxmd.com/read/29319764/prevalence-of-chronic-kidney-disease-in-a-population-in-southern-brazil-pro-renal-study
#12
Ana Paula Piccolli, Marcelo Mazza do Nascimento, Miguel Carlos Riella
INTRODUCTION: Chronic kidney disease (CKD) affects 10-12% of the adult population in many countries. In Brazil, there is no reliable information about the actual prevalence of CKD. OBJECTIVE: To determine the prevalence of CKD by estimated glomerular filtration rate (eGFR) and proteinuria/albuminuria in an urban population randomly selected in Southern Brazil. Patients and. METHODS: 5,216 individuals were randomly selected out of a pool of 10,000 individuals identified from the database of a local energy company...
October 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29306458/impact-of-subclinical-hypothyroidism-on-clinical-outcomes-following-percutaneous-coronary-intervention
#13
Yonggu Lee, Young-Hyo Lim, Jeong-Hun Shin, Jinkyu Park, Jinho Shin
BACKGROUND: Similar to overt hypothyroidism, subclinical hypothyroidism (SCH) has been reported to increase the risk of cardiovascular disease. However, the influence of SCH on clinical outcomes following percutaneous coronary intervention (PCI) remains unclear. METHODS: We performed a prospective cohort study. SCH was defined as a thyroid-stimulating hormone (TSH) level ≥4.5mIU/l and a normal level of free thyroxine (FT4). A composite event was defined as the combination of cardiac death, non-fatal myocardial infarction (MI) and repeat revascularization...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29303915/robotic-kidney-transplantation-dream-or-future
#14
Franck Bruyère, Nicolas Doumerc
PURPOSE OF REVIEW: Kidney transplantation is the preferred modality for the treatment of patients with end-stage renal disease. Robot-assisted kidney transplantation (RAKT) has been in use since 2002 to reduce morbidity in open kidney transplantation. The aim of this review is to highlight the most relevant publications on this challenging surgical topic. RECENT FINDINGS: Recent publications suggest that minimally invasive techniques in kidney transplantation, including RAKT, have shown promising results particularly with regard to complications and recovery, reducing postoperative pain and analgesic requirement with a better cosmetic result...
January 4, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29301473/blood-pressure-control-over-time-in-childhood-onset-systemic-lupus-erythematous
#15
P O Avar Aydin, J Shan, H I Brunner, M M Mitsnefes
Introduction Hypertension (HTN) is prevalent in patients with systemic lupus erythematosus (SLE) and causes early cardiovascular aging and progression of renal and cardiac disease. The aim of this longitudinal retrospective study was to evaluate the prevalence of HTN, the follow-up blood pressure trends, and risk factors for HTN in a population-based cohort with childhood-onset SLE (cSLE). Methods Demographic and clinical data of consecutive visits from the baseline to the last visit were extracted from electronic medical records of patients with cSLE...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29301371/the-sodium-glucose-cotransporter-2-inhibitor-dapagliflozin-prevents-renal-and-liver-disease-in-western-diet-induced-obesity-mice
#16
Dong Wang, Yuhuan Luo, Xiaoxin Wang, David J Orlicky, Komuraiah Myakala, Pengyuan Yang, Moshe Levi
Obesity and obesity related kidney and liver disease have become more prevalent over the past few decades, especially in the western world. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of antidiabetic agents with promising effects on cardiovascular and renal function. Given SGLT2 inhibitors exert both anti-diabetic and anti-obesity effects by promoting urinary excretion of glucose and subsequent caloric loss, we investigated the effect of the highly selective renal SGLT2 inhibitor dapagliflozin in mice with Western diet (WD) induced obesity...
January 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29300770/oxytocin-is-lower-in-african-american-men-with-diabetes-and-associates-with-psycho-social-and-metabolic-health-factors
#17
Yuval Eisenberg, Lara R Dugas, Arfana Akbar, Bharathi Reddivari, Brian T Layden, Elena Barengolts
OBJECTIVE: Recently, it has been suggested that oxytocin (OT) has a role in metabolism and neuropsychiatry health and disease, and therefore, it may represent a potential therapeutic target. The current study aimed to investigate relationships between OT and glycemic status along with psycho-social and behavioral factors. DESIGN AND METHODS: A total of 92 obese or overweight, African American, male subjects were enrolled in the study. Biometric and biochemical data were collected including oral glucose tolerance testing and urinary OT (measured by ELISA)...
2018: PloS One
https://www.readbyqxmd.com/read/29298567/sodium-excretion-and-associated-factors-in-urine-samples-of-african-descendants-in-alc%C3%A3-ntara-brazil-a-population-based-study
#18
Elisângela Milhomem Dos Santos, Dyego José de Araújo Brito, Isabela Leal Calado, Ana Karina Teixeira França, Joyce Santos Lages, Francisco das Chagas Monteiro Junior, Alcione Miranda Dos Santos, Natalino Salgado Filho
In most countries, salt intake has been excessive and constitutes one of the main risk factors for disease development, especially hypertension. Factors such as age, gender, sedentary lifestyle, smoking, African descent, obesity, dietary habits and family history of hypertension may be associated with high blood pressure. Studies show a positive association between the excretion of sodium and increased blood pressure. We evaluated the urinary excretion of sodium and associated factors in isolated urine samples of African descendants from remaining Quilombos...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29296046/the-association-of-serum-leptin-levels-with-metabolic-diseases
#19
REVIEW
Jen-Pi Tsai
Leptin is a 167-amino-acid protein released by white adipose tissue and encoded by the obese gene. It has a role as a negative regulator of appetite control through sending a satiety signal to act on receptors within the hypothalamus. At normal levels, leptin can exert its effects on weight regulation according to white fat mass, induce sodium excretion, maintain vascular tone, and repair the myocardium. Beyond these effects, elevated serum leptin levels have been implicated in the pathogenesis of metabolic syndrome, diabetes mellitus, hypertension, and multiple cardiovascular diseases...
October 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29284990/the-impact-of-risk-factors-and-comorbidities-on-the-incidence-of-atrial-fibrillation
#20
Nabil Naser, Mirza Dilic, Azra Durak, Mehmed Kulic, Esad Pepic, Elnur Smajic, Zumreta Kusljugic
Introduction: Atrial fibrillation (AF) is the most common form of cardiac arrhythmia in clinical practice and its prevalence increases with age. Patients who develop AF also have cardiovascular risk factors, structural heart disease, and comorbidities, all of which can increase mortality. AF causes a significant economic burden with the increasing trend in AF prevalence and hospitalizations. Research Objectives: The objective of our study is to evaluate the impact of the most common known risk factors on the incidence of atrial fibrillation as an important precursor of cardiac and cerebrovascular morbidity and mortality among our patients in Bosnia and Herzegovina during median follow up period (September 2006 - September 2016)...
December 2017: Materia Socio-medica
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