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https://www.readbyqxmd.com/read/29779672/modifiable-risk-factors-to-reduce-renal-cell-carcinoma-incidence-insight-from-the-plco-trial
#1
Jonathan Gelfond, Osamah Al-Bayati, Aashish Kabra, Kevan Iffrig, Dharam Kaushik, Michael A Liss
INTRODUCTION: Identify modifiable factors contributing to renal cell carcinoma in the PCLO to target disease prevention and reduce health care costs. METHODS: The prostate, lung, colorectal, and ovarian database were queried for the primary outcome of kidney cancer. Demographics were investigated, specifically focusing on modifiable risk factors. Statistical analysis includes the Student t-test for continuous variables, chi-squared or Fisher's exact tests for dichotomous and categorical variables for bivariate analysis...
May 17, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29779026/uromodulin-mrna-from-urinary-extracellular-vesicles-correlate-to-kidney-function-decline-in-type-2-diabetes-mellitus
#2
Cindy M Yamamoto, Taku Murakami, Melanie L Oakes, Masato Mitsuhashi, Colleen Kelly, Robert R Henry, Kumar Sharma
BACKGROUND: Extracellular vesicles (EVs) enclose mRNA derived from their cell of origin and are considered a source of potential biomarkers. We examined urinary EV mRNA from individuals with diabetic kidney disease (DKD), chronic kidney disease, type 2 diabetes (T2DM), and obese and healthy controls to determine if such biomarkers had the potential to classify kidney disease and predict patients at higher risk of renal function decline. METHODS: A total of 242 participants enrolled in this study...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29778999/idiopathic-nodular-glomerulosclerosis-ing-in-an-african-american-aa-man-with-hepatitis-c
#3
Nirmal K Onteddu, Jayasri Duggirala, Anand C Reddy
Idiopathic nodular glomerulosclerosis (ING) in a non-diabetic patient is uncommon. Nodular glomerulosclerosis is hallmark sign of diabetic nephropathy. ING is a very rare clinicopathological disease associated with smoking, obesity and hypertension, chronic obstructive pulmonary disease and metabolic syndrome. A 68-year-old non-obese African American man with hypertension, smoking and history of hepatitis C presented to the clinic with progressive worsening of lower extremity oedema and declining renal function over few months...
May 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29768438/survival-in-patients-on-hemodialysis-effect-of-gender-according-to-body-mass-index-and-creatinine
#4
Jeung-Min Park, Jong-Hak Lee, Hye Min Jang, Yeongwoo Park, Yon Su Kim, Shin-Wook Kang, Chul Woo Yang, Nam-Ho Kim, Eugene Kwon, Hyun-Ji Kim, Ji-Eun Lee, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Jang-Hee Cho, Yong-Lim Kim
BACKGROUND: The association of a higher body mass index (BMI) with better survival is a well-known "obesity paradox" in patients on hemodialysis (HD). However, men and women have different body compositions, which could impact the effect of BMI on mortality. We investigated the effect of gender on the obesity-mortality relationship in Korean patients on HD. METHODS: This study included 2,833 maintenance patients on HD from a multicenter prospective cohort study in Korea (NCT00931970)...
2018: PloS One
https://www.readbyqxmd.com/read/29766469/proteinuric-glomerulopathy-in-an-adolescent-with-a-distal-partial-trisomy-chromosome-1
#5
Takaya Sasaki, Masahiro Okabe, Takeshi Tosaki, Yu Honda, Masahiro Ishikawa, Nobuo Tsuboi, Takashi Yokoo
We report a case of distal partial trisomy 1 from q32.1 to 41 that have exhibited proteinuric glomerulopathy. The patient was a 17-year-old adolescent with clinical features of low birth weight, mild mental retardation and mild deafness, from the birth. He exhibited non-nephrotic range proteinuria with the mild obesity since the age of sixteen. Image studies did not reveal morphological abnormalities of the kidneys. Renal biopsy findings showed no definitive evidence of primary glomerular diseases, and were characterized by a very low glomerular density, glomerulomegaly and focal effacement of podocyte foot processes...
May 16, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29764624/hydrolyzed-proteins-from-herring-and-salmon-rest-raw-material-contain-peptide-motifs-with-angiotensin-i-converting-enzyme-inhibitors-and-resulted-in-lower-urine-concentrations-of-protein-cystatin-c-and-glucose-when-fed-to-obese-zucker-fa-fa-rats
#6
Aslaug Drotningsvik, Daniela Maria Pampanin, Rasa Slizyte, Ana Carvajal, Ingmar Høgøy, Tore Remman, Oddrun Anita Gudbrandsen
The use of angiotensin-I converting enzyme (ACE) inhibitors is a common strategy for treating kidney disease. Several amino acid sequences with ACE inhibiting activity are identified in filet and rest raw material from various species of fish, and fish protein hydrolysates could be of interest for possible treatment or prevention of kidney disease. Therefore, we hypothesized that protein hydrolysates from rest raw material from herring and salmon contained ACE inhibiting motifs, and could beneficially affect typical markers for kidney function in an obesity rat model prone to developing renal failure...
April 2018: Nutrition Research
https://www.readbyqxmd.com/read/29764441/case-report-identification-of-an-hnf1b-p-arg527gln-mutation-in-a-maltese-patient-with-atypical-early-onset-diabetes-and-diabetic-nephropathy
#7
Nikolai Paul Pace, Johann Craus, Alex Felice, Josanne Vassallo
BACKGROUND: The diagnosis of atypical non-autoimmune forms of diabetes mellitus, such as maturity onset diabetes of the young (MODY) presents several challenges, in view of the extensive clinical and genetic heterogeneity of the disease. In this report we describe a case of atypical non autoimmune diabetes associated with a damaging HNF1β mutation. This is distinguished by a number of uncharacteristic clinical features, including early-onset obesity, the absence of renal cysts and diabetic nephropathy...
May 15, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29764436/prevalence-and-incidence-of-complications-at-diagnosis-of-t2dm-and-during-follow-up-by-bmi-and-ethnicity-a-matched-case-control-analysis
#8
Ebenezer S Owusu Adjah, Srikanth Bellary, Wasim Hanif, Kiran Patel, Kamlesh Khunti, Sanjoy K Paul
AIMS: To estimate the risk of developing long-term major cardiovascular and renal complications in relation to levels of body mass index (BMI) in a population of White European (WE), African-Caribbean (AC), and South Asian (SA) patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Patients with new diagnosis of T2DM, aged ≥ 18 years from January 2000 (n = 69,436) and their age-sex-ethnicity matched non-diabetic controls (n = 272,190) were identified from UK primary care database...
May 15, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29761105/prevalence-of-proteinuria-and-albuminuria-in-an-obese-population-and-associated-risk-factors
#9
Jordan L Rosenstock, Max Pommier, Guillaume Stoffels, Satyam Patel, Michael F Michelis
Obesity has been increasingly recognized as a risk factor for kidney disease and both proteinuria and microalbuminuria have been associated with obesity. The actual prevalence of microalbuminuria and proteinuria in obese patients in the United States (US) has not been clearly described in the literature. Furthermore, obesity is associated with risk factors of kidney disease, such as diabetes and hypertension (HTN), and the prevalence of proteinuria and albuminuria excluding these risk factors is uncertain. In this study, we collected urine albumin/creatinine and urine protein/creatinine ratios on obese patients undergoing bariatric surgery to determine the prevalence of albuminuria and proteinuria in obese patients with and without associated diabetes and HTN...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29757885/maximizing-your-nutrition-minute-bridging-nutritional-gaps-across-the-life-span
#10
Wendy L Wright, Kathleen M Zelman
BACKGROUND AND PURPOSE: Poor diet quality has been associated with increased mortality and an increased risk of chronic disease. Given the shortfalls in the typical American diet and the prevalence of nutrition-related chronic disease among US adults, the need for nutrition education is paramount. Nurse practitioners (NPs) are well placed to provide basic nutrition counseling but often face challenges to making this a reality. In a typical office visit, the time available to discuss diet and nutrition can be as little as one minute or less...
March 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29755574/branched-chain-amino-acids-in-health-and-disease-metabolism-alterations-in-blood-plasma-and-as-supplements
#11
REVIEW
Milan Holeček
Branched-chain amino acids (BCAAs; valine, leucine, and isoleucine) are essential amino acids with protein anabolic properties, which have been studied in a number of muscle wasting disorders for more than 50 years. However, until today, there is no consensus regarding their therapeutic effectiveness. In the article is demonstrated that the crucial roles in BCAA metabolism play: (i) skeletal muscle as the initial site of BCAA catabolism accompanied with the release of alanine and glutamine to the blood; (ii) activity of branched-chain keto acid dehydrogenase (BCKD); and (iii) amination of branched-chain keto acids (BCKAs) to BCAAs...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29754804/diabetes-mellitus-and-cardiovascular-risk-update-of-the-recommendations-of-the-diabetes-and-cardiovascular-disease-working-group-of-the-spanish-diabetes-society-sed-2018
#12
Francisco Arrieta, Pedro Iglesias, Juan Pedro-Botet, Antonio Becerra, Emilio Ortega, Juan Carlos Obaya, Andreu Nubiola, Gonzalo Fernando Maldonado, Maria Del Mar Campos, Romina Petrecca, José Luis Pardo, Víctor Sánchez-Margalet, José Juan Alemán, Jorge Navarro, Santiago Duran, Francisco Javier Tébar, Manuel Aguilar, Fernando Escobar
This document is an update to the clinical practice recommendations for the management of cardiovascular risk factors in diabetes mellitus. The consensus is made by members of the Cardiovascular Risk Group of the Spanish Diabetes Society. We have proposed and updated interventions on lifestyle, pharmacological treatment indicated to achieve therapeutic objectives according to the levels of HbA1c, degree of obesity, hypertension, hyperlipidemia, heart failure, platelet antiagregation, renal insufficiency, and diabetes in the elderly, as well as new biomarkers of interest in the evaluation of cardiovascular risk in individuals with diabetes mellitus...
May 10, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29742114/the-magnitude-of-obesity-and-metabolic-syndrome-among-diabetic-chronic-kidney-disease-population-a-nationwide-study
#13
Piyawan Kittiskulnam, Nintita Sripaiboonkij Thokanit, Pisut Katavetin, Paweena Susanthitaphong, Nattachai Srisawat, Kearkiat Praditpornsilpa, Kriang Tungsanga, Somchai Eiam-Ong
BACKGROUND: Although the prevalence of obesity and metabolic syndrome (MetS) among dialysis patients has been exceeding than general population, little is known regarding obesity and MetS in non-dialysis chronic kidney disease (CKD). We aimed to find the magnitude of obesity and MetS and their associations with impaired renal function among type 2 diabetes mellitus (T2DM) patients. METHODS: A national survey of T2DM patients was collected in the Thai National Health Security Office database during 2014-5...
2018: PloS One
https://www.readbyqxmd.com/read/29738479/animal-and-plant-protein-intake-and-body-mass-index-and-waist-circumference-in-a-korean-elderly-population
#14
Ki-Byeong Park, Hyun Ah Park, Jae-Heon Kang, Kyoungwoo Kim, Young Gyu Cho, Jinyoung Jang
Controversy exists on whether animal and plant proteins influence obesity differently. The purpose of this study was to evaluate the association between total, animal, and plant protein intake with the body mass index (BMI), waist circumference (WC), and renal function in the Korean elderly. Study participants included Korean adults aged 60 years or older from the Korean National Health and Nutrition Examination Survey in 2013⁻2014. Height, weight, and waist circumference were measured and the body mass index was calculated...
May 8, 2018: Nutrients
https://www.readbyqxmd.com/read/29734147/large-renal-corpuscle-clinical-significance-of-evaluation-of-the-largest-renal-corpuscle-in-kidney-biopsy-specimens
#15
Hiroshi Kataoka, Toshio Mochizuki, Kosaku Nitta
Renal prognostic factors of chronic kidney disease are important concerns for patients. Kidney biopsy can be used to evaluate not only the activity of the original disease but also various risk factors related to the lifestyle of patients. Considering that lifestyle-related factors, including obesity and metabolic syndrome, are crucial prognostic risk factors of kidney disease progression and all-cause mortality, evaluation of lifestyle-related prognostic factors in kidney biopsy of all kidney diseases is important...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29731021/pathophysiological-links-between-diabetes-and-blood-pressure
#16
REVIEW
Renata Libianto, Duygu Batu, Richard J MacIsaac, Mark E Cooper, Elif I Ekinci
Hypertension is highly prevalent among people with diabetes, and the presence of diabetes among those with hypertension portends an increase in cardiovascular risk. In this review we aim to explore the pathophysiological links between diabetes and hypertension. Renal sodium handling differs in diabetes because there is an upregulation of sodium transporters in the kidneys. The renin-angiotensin-aldosterone system may be upregulated in diabetes, leading to hypertension through a direct effect mediated by angiotensin II, as well as indirectly through upregulation of sympathetic activity...
May 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29728317/obesity-metabolic-abnormality-and-progression-of-ckd
#17
Hae-Ryong Yun, Hyoungnae Kim, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Shin-Wook Kang, Kyu Hun Choi, Suah Sung, Soo Wan Kim, Joongyub Lee, Kook-Hwan Oh, Curie Ahn, Seung Hyeok Han
RATIONALE & OBJECTIVE: Recent studies have yielded conflicting findings on the association between obesity and progression of chronic kidney disease (CKD). Few studies have evaluated whether metabolic abnormalities may accelerate the rate of progression of CKD. STUDY DESIGN: Prospective observational cohort study. SETTING & PARTICIPANTS: 1,940 participants from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) PREDICTORS: Obesity and metabolic abnormality...
May 2, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29725634/bowman-capsule-volume-and-related-factors-in-adults-with-normal-renal-function
#18
Takaya Sasaki, Nobuo Tsuboi, Kotaro Haruhara, Yusuke Okabayashi, Go Kanzaki, Kentaro Koike, Akimitsu Kobayashi, Izumi Yamamoto, Makoto Ogura, Takashi Yokoo
Introduction: Alterations in glomerular filtration can considerably influence the dynamics and functions of the Bowman capsule. Despite the potentially important role in maintaining normal renal functions, few studies have focused on Bowman capsule volume in normal human kidneys. Methods: We analyzed specimens from biopsies performed 1 hour after kidney transplantation from living donors without apparent renal disease. The measurements of all cross-sectional areas of the Bowman capsules and glomerular capillaries were used to estimate the mean Bowman capsule volume (BV) and glomerular capillary volume (GV) in each subject...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29725581/a-high-ankle-brachial-index-is-associated-with-obesity-and-low-serum-25-hydroxyvitamin-d-in-patients-with-diabetes
#19
Barbara Depczynski, Tamara Young, Christopher White
Peripheral artery disease (PAD), when present with diabetes, is associated with significant morbidity and mortality. The spectrum of PAD in diabetes includes atherosclerosis with stenotic disease; and diffuse medial calcification with non-compliant arteries, as reflected by high ankle brachial index. The clinical characteristics of a high ABI are less well characterized than that of low ABI. The aim of this study was to determine the unique clinical phenotype of patients with diabetes who have high ankle brachial index (ABI) reading...
March 2018: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29720598/relationship-between-body-mass-index-and-renal-function-deterioration-among-the-taiwanese-chronic-kidney-disease-population
#20
Tian-Jong Chang, Cai-Mei Zheng, Mei-Yi Wu, Tzu-Ting Chen, Yun-Chun Wu, Yi-Lien Wu, Hsin-Ting Lin, Jing-Quan Zheng, Nain-Feng Chu, Yu-Me Lin, Sui-Lung Su, Kuo-Cheng Lu, Jin-Shuen Chen, Fung-Chang Sung, Chien-Te Lee, Yu Yang, Shang-Jyh Hwang, Ming-Cheng Wang, Yung-Ho Hsu, Hung-Yi Chiou, Senyeong Kao, Yuh-Feng Lin
This study investigated the characteristics of patients with different chronic kidney disease (CKD) stages according to various body mass index (BMI) categories and determined the influence of BMI in renal function deterioration. We conducted a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of CKD project (2008-2013) and National Health Insurance Research Database (2001-2013). A total of 7357 patients with CKD aged 20-85 years from 14 hospitals were included in the study...
May 2, 2018: Scientific Reports
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