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https://www.readbyqxmd.com/read/29353464/laparoscopic-2port-varicocelectomy-with-scarless-periumblical-mini-incision-initial-experience-in-approach-and-outcomes
#1
Won Ik Seo, Jong Kyou Kwon, Pil Moon Kang, Wansuk Kim, Jang Ho Yoon, Taek Sang Kim, Jae Seung Chung, Cheol Kyu Oh
PURPOSE: As with other areas, there have been many efforts for minimally invasive surgery in varicocelectomy. We present our initial experience with laparoscopic varicocelectomy with a two-port scarless periumbilical mini-incision. MATERIALS AND METHODS: The study enrolled 18 patients who underwent laparoscopic varicocelectomy with a twoportscarless periumbilical mini-incision from February 2012 to April 2013. The laparoscopic varicocelectomy was performed using two 5-mm ports at periumbilical sites in skin creases...
January 21, 2018: Urology Journal
https://www.readbyqxmd.com/read/29353456/in-vivo-transient-and-partial-cell-reprogramming-to-pluripotency-as-a-therapeutic-tool-for-neurodegenerative-diseases
#2
REVIEW
S Tamanini, G P Comi, S Corti
In theory, human diseases in which a specific cell type degenerates, such as neurodegenerative diseases, can be therapeutically addressed by replacement of the lost cells. The classical strategy for cell replacement is exogenous cell transplantation, but now, cell replacement can also be achieved with in situ reprogramming. Indeed, many of these disorders are age-dependent, and "rejuvenating" strategies based on cell epigenetic modifications are a possible approach to counteract disease progression. In this context, transient and/or partial reprogramming of adult somatic cells towards pluripotency can be a promising tool for neuroregeneration...
January 20, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29353426/is-dipyrone-effective-as-a-preemptive-analgesic-in-third-molar-surgery-a-pilot-study
#3
Vinícius Tatsumoto Favarini, Carlos Alysson Aragão Lima, Rogério Almeida da Silva, Fábio Ricardo Loureiro Sato
PURPOSE: Studies on preemptive analgesia in maxillofacial surgery have shown several controversial clinical results, mainly due to the absence of a methodological standard, besides a wide variety of studied drugs. This study intended to answer the following hypothesis: Is the administration of dipyrone preemptively capable of decreasing trans- and postoperative pain in the third molar surgical extraction? METHODS: A pilot prospective double-blind placebo-controlled study was carried out with 25 patients submitted to the third molar surgical extraction at two moments, one side in each intervention...
January 20, 2018: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29353388/outcomes-and-cost-effectiveness-of-ultrasound-guided-injection-of-the-trochanteric-bursa
#4
William G Mitchell, Sharon C Kettwich, Wilmer L Sibbitt, Randy R Sibbitt, Maheswari Muruganandam, Noelle A Rolle, William A Hayward, Roderick A Fields, Luis P Roldan, N Suzanne Emil, Monthida Fangtham, Arthur D Bankhurst
We hypothesized that ultrasound (US) guidance improves outcomes of corticosteroid injection of trochanteric bursitis. 40 patients with greater trochanteric pain syndrome defined by pain to palpation over the trochanteric bursa were randomized to injection with 5 ml of 1% lidocaine and 80 mg of methylprednisolone using (1) conventional anatomic landmark palpation guidance or (2) US guidance. Procedural pain (Visual Analogue Pain Scale), pain at outcome (2 weeks and 6 months), therapeutic duration, time-to-next intervention, and costs were determined...
January 20, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29353327/transforaminal-endoscopic-decompression-for-thoracic-spinal-stenosis-under-local-anesthesia
#5
REVIEW
Zhi-Qiang Jia, Xi-Jing He, Li-Tao Zhao, San-Qiang Li
BACKGROUND: Thoracic spinal stenosis is a common vertebral degenerative disease, and treatment remains challenging. In recent years, transforaminal endoscopic decompression has been widely used for treating lumbar degenerative diseases. However, the efficacy of this procedure for thoracic spinal stenosis has yet to be established. Herein, we report a case of thoracic spinal stenosis treated with transforaminal endoscopic decompression under local anesthesia. CASE REPORT: An 88-year-old man presented with a 1-month history of progressive paralysis and dysesthesia in the bilateral lower extremities...
January 20, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29353286/predictors-of-thrombocytopenia-after-self-expandable-transcatheter-aortic-valve-replacement-a-single-center-experience-from-china
#6
Qifeng Zhu, Xianbao Liu, Wei He, Yuxin He, Mengyao Tang, Yinghao Sun, Xiaobin Xu, Keda Shi, Huijia Kong, Jubo Jiang, Liangwei Chen, Jie Chen, Po Hu, Qiyuan Xu, Jianan Wang
OBJECTIVES: The importance of thrombocytopenia (TP) has been discussed previously. However, data are still limited, especially on predictors of TP. We sought to investigate predictors of TP after transcatheter aortic valve replacement (TAVR), in particular, clinically significant TP. METHODS: We reviewed a total of 123 consecutive patients undergoing TAVR in our medical center. They were stratified into 3 groups according to the nadir platelet count post-TAVR: no/mild TP, moderate TP, and severe TP...
January 20, 2018: Cardiology
https://www.readbyqxmd.com/read/29353257/ethical-dilemmas-of-recording-and-reviewing-neonatal-resuscitation
#7
REVIEW
Maria C den Boer, Mirjam Houtlosser, Henriëtte Anje van Zanten, Elizabeth E Foglia, Dirk P Engberts, Arjan B Te Pas
Neonatal resuscitation is provided to approximately 3% of neonates. Adequate ventilation is often the key to successful resuscitation, but this can be difficult to provide. There is increasing evidence that inappropriate respiratory support can have severe consequences. Several neonatal intensive care units have recorded and reviewed neonatal resuscitation procedures for quality assessment, education and research; however, ethical dilemmas sometimes make it difficult to implement this review process. We reviewed the literature on the development of recording and reviewing neonatal resuscitation and have summarised the ethical concerns involved...
January 20, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29353143/contractile-effect-of-rifaximin-on-bovine-uterus-in-the-presence-of-steroid-hormone-antagonists
#8
R L Sciorsci, M Piccinno, A Rizzo
This in vitro study investigated the modulatory effect of rifaximin on bovine uterus contractility, in both phases of the oestrous cycle, with and without the steroid hormones that are predominant in the respective phases: oestrogen in the follicular phase and progesterone in the luteal phase. The procedures were conducted in an isolated organ bath by using rifaximin alone (10-4 M) and in association with the steroid hormone antagonists (10-5 M) tamoxifen (oestrogen antagonist) in the follicular phase and mifepristone (progesterone antagonist) in the luteal phase...
January 10, 2018: Theriogenology
https://www.readbyqxmd.com/read/29353140/development-of-sea-bream-sparus-aurata-semen-vitrification-protocols
#9
Loredana Zilli, Annalisa Bianchi, Maroua Sabbah, Laura Pecoraro, Roberta Schiavone, Sebastiano Vilella
The long-term goal of this research project is to set up efficient protocol that can be used to develop a standardized approach for vitrification of marine fish spermatozoa. In particular, the aim of the present study was to develop a vitrification protocol for sea bream (Sparus aurata) spermatozoa. To draw up the protocol, we tested two different dilution media (1% NaCl and Mounib medium), three different vitrification devices (loops, drops and cut straws), different cryoprotectants (CPs) and three different equilibration times (30, 60 and 120 s)...
January 11, 2018: Theriogenology
https://www.readbyqxmd.com/read/29353113/cadmium-immobilization-in-river-sediment-using-stabilized-nanoscale-zero-valent-iron-with-enhanced-transport-by-polysaccharide-coating
#10
Danlian Huang, Zhengxun Hu, Zhiwei Peng, Guangming Zeng, Guomin Chen, Chen Zhang, Min Cheng, Jia Wan, Xi Wang, Xiang Qin
Proper management of metal-contaminated sediment plays a key role in sediment recovery and reuse. This study synthesized two kinds of stabilized nanoscale zero-valent iron (nZVI) with starch (S-nZVI) and carboxymethyl cellulose (C-nZVI) for the in situ immobilization of Cd(II) in river sediment and investigated their transport in porous media. Experimental data showed that when the sediment sample was treated with C-nZVI for 56 days at a dosage ranging from 5 to 10 mg/g-sediment as Fe0, the TCLP (toxicity characteristic leaching procedure) leachability of Cd(II) in the sediment decreased by 93...
January 17, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29353081/hydrogels-based-on-poly-methyl-vinyl-ether-co-maleic-acid-and-tween-85-for-sustained-delivery-of-hydrophobic-drugs
#11
Eneko Larrañeta, Laura Barturen, Michael Ervine, Ryan F Donnelly
Hydrogels based on poly(methyl vinyl ether-co-maleic acid) and Tween 85 were prepared for hydrophobic drug delivery. The hydrogels were synthesized following a simple procedure carried out in solid state. The process did not require the use of any solvent and, as it is based on an esterification reaction, no toxic by-products were obtained. The resulting hydrogels contained Tween 85 inside the structure and due to the amphiphilic nature of this compound, hydrophobic domains within the hydrogel structure were formed...
January 15, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29353029/applying-surgical-antimicrobial-standards-in-cesarean-deliveries
#12
Kathryn E Fay, Lynn Yee
Antimicrobial prophylaxis practices are critical to surgical site infection risk reduction strategies. Included in these practices is antibiotic redosing following prolonged procedures or after large blood losses. Guidelines have been published by several professional associations with most endorsing repeat antibiotic administration after an estimated blood loss of 1500ml or following two half-lives of the select agent. These conventions have been widely adopted by surgeons with the exception of obstetricians at the time of cesarean delivery...
January 15, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29352971/magnetic-anchor-guided-endoscopic-submucosal-dissection-for-gastric-lesions-with-video
#13
Ippei Matsuzaki, Masashi Hattori, Ken Hirose, Masaya Esaki, Masakatsu Yoshikawa, Takio Yokoi, Makoto Kobayashi, Ryoji Miyahara, Yoshiki Hirooka, Hidemi Goto
BACKGROUND AND AIM: The feasibility of magnetic anchor-guided endoscopic submucosal dissection (MAG-ESD) using a neodymium magnet for gastric lesions has not been clarified. The aim of study was to evaluate the feasibility of MAG-ESD using neodymium magnets while treating gastric lesions. METHODS: This prospective trial was conducted at the Yamashita Hospital. The MAG-ESD was performed for 50 gastric lesions using an insulated-tip knife. The magnetic anchor consisted of an internal neodymium magnet attached to a hemoclip with 3-0 silk...
January 15, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29352965/establishment-of-a-protocol-for-the-isolation-of-feline-pancreatic-islets
#14
I R Brandão, E Zini, C E Reusch, T A Lutz, M Osto
Diabetes mellitus is a common endocrinopathy in cats that is associated with pancreatic islets lesions. Research on isolated islets contributed to the understanding of the pathophysiology of human diabetes. Therefore, by improving the existing methods of isolation in cats, we aimed at increasing islet yield, purity and viability of feline isolated islets. Islet isolation was accomplished by pancreas perfusion with 80ml of Collagenase type IV through the pancreatic duct at the site of the major papilla. The enzymatic digestion was combined with mechanical disruption and controlled by dithizone staining...
January 15, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29352925/influence-of-hydrothermal-treatment-on-the-structural-modification-of-spent-grain-specific-carbohydrates-and-the-formation-of-degradation-products-using-model-compounds
#15
J Steiner, K Franke, M Kießling, S Fischer, S Töpfl, V Heinz, T Becker
Brewer's spent grain (BSG) constitutes various valuable carbohydrates that may contribute to a healthy diet. These components may be obtained from BSG via hydrothermal treatment (HT), a procedure for dissolving water-inextricable carbohydrates. The objective of this study was to investigate HT as an environmentally friendly technology for extracting high-molecular-weight fiber with proven beneficial effects on human health. Cellulose, β-glucan, and arabinoxylan (AX) served as model substances and were subjected to auto-hydrolysis at different temperatures and reaction times...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352812/usefulness-of-a-visual-aid-in-achieving-optimal-positioning-for-spinal-anesthesia-a-randomized-trial
#16
Usha Gurunathan, Shakeel Meeran Kunju, Karen Elizabeth Hay, Sharyn van Alphen
BACKGROUND: Optimal patient positioning is perceived as an essential factor to increase the success of performing neuraxial blockade. The primary objective of this study was to evaluate the benefit of using a visual image in addition to verbal instructions in order to optimize positioning for spinal block. METHODS: This was a prospective randomized controlled trial on 85 adult patients undergoing lower limb joint replacements at a tertiary academic hospital. Group 1(n = 43) randomized to receive standardized verbal instructions; Group 2 (n = 42) received standardized verbal instructions in conjunction with visual aids to achieve positioning for spinal anesthesia...
January 20, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29352799/an-atomistic-fingerprint-algorithm-for-learning-ab-initio-molecular-force-fields
#17
Yu-Hang Tang, Dongkun Zhang, George Em Karniadakis
Molecular fingerprints, i.e., feature vectors describing atomistic neighborhood configurations, is an important abstraction and a key ingredient for data-driven modeling of potential energy surface and interatomic force. In this paper, we present the density-encoded canonically aligned fingerprint algorithm, which is robust and efficient, for fitting per-atom scalar and vector quantities. The fingerprint is essentially a continuous density field formed through the superimposition of smoothing kernels centered on the atoms...
January 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29352791/kohn-sham-potentials-from-electron-densities-using-a-matrix-representation-within-finite-atomic-orbital-basis-sets
#18
Xing Zhang, Emily A Carter
We revisit the static response function-based Kohn-Sham (KS) inversion procedure for determining the KS effective potential that corresponds to a given target electron density within finite atomic orbital basis sets. Instead of expanding the potential in an auxiliary basis set, we directly update the potential in its matrix representation. Through numerical examples, we show that the reconstructed density rapidly converges to the target density. Preliminary results are presented to illustrate the possibility of obtaining a local potential in real space from the optimized potential in its matrix representation...
January 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29352753/factors-predicting-length-of-stay-following-bariatric-surgery-retrospective-review-of-a-single-uk-tertiary-centre-experience
#19
Fahad Mahmood, Alistair J Sharples, Adriana Rotundo, Nagammapudur Balaji, Vittal S R Rao
BACKGROUND: Laparoscopic Roux Y gastric bypass (RYGB) and laparoscopic sleeve gastrectomy (LSG) are the most commonly performed bariatric procedures. Improvement in techniques and perioperative management of patients have resulted in shorter hospital stay and reduced overall costs. Many post-operative protocols aspire to post-operative day 1 discharge with studies showing reduction in length of stay without increasing complications. In this study, we investigate the factors predictive of early discharge at our high-volume bariatric centre...
January 19, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29352711/gold-cleaning-methods-for-preparation-of-cell-culture-surfaces-for-self-assembled-monolayers-of-zwitterionic-oligopeptides
#20
Junko Enomoto, Tatsuto Kageyama, Dina Myasnikova, Kisaki Onishi, Yuka Kobayashi, Yoko Taruno, Takahiro Kanai, Junji Fukuda
Self-assembled monolayers (SAMs) have been used to elucidate interactions between cells and material surface chemistry. Gold surfaces modified with oligopeptide SAMs exhibit several unique characteristics, such as cell-repulsive surfaces, micropatterns of cell adhesion and non-adhesion regions for control over cell microenvironments, and dynamic release of cells upon external stimuli under culture conditions. However, basic procedures for the preparation of oligopeptide SAMs, including appropriate cleaning methods of the gold surface before modification, have not been fully established...
January 15, 2018: Journal of Bioscience and Bioengineering
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