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https://www.readbyqxmd.com/read/29211299/endoplasmic-reticulum-stress-induced-lox-1-cd15-polymorphonuclear-myeloid-derived-suppressor-cells-in-hepatocellular-carcinoma
#1
Nan Jiang, Yan-Fang Xing, Bo Hu, Jian-Xin Tang, Hui-Min Dong, Yu-Mei He, Dan-Yun Ruan, Qing-Jian Ye, Jia-Rong Cai, Xiao-Kun Ma, Jie Chen, Xiu-Rong Cai, Ze-Xiao Lin, Xiang-Yuan Wu, Xing Li
AIM: A recent study indicated that Lectin-type oxidized LDL receptor-1 (LOX-1) was a distinct surface marker for human polymorphonuclears myeloid-derived suppressor cells (PMN-MDSC). The present study was aimed to investigate the existence LOX-1 PMN-MDSC in hepatocellular carcinoma (HCC) patients. METHODS: 127 HCC patients, 10 patients with mild active chronic hepatits B, 10 liver cirrhosis due to hepatitis B, 10 liver dysplastic node with hepatitis B and 50 health control were included...
December 6, 2017: Immunology
https://www.readbyqxmd.com/read/29205940/relation-of-serum-adma-apelin-13-and-lox-1-levels-with-inflammatory-and-echocardiographic-parameters-in-hemodialysis-patients
#2
Ibrahim Dogan, Tolga Dogan, Mucahit Yetim, Huseyin Kayadibi, Mehmet B Yilmaz, Baris Eser, Macit Kalcik, Yusuf Karavelioglu
Cardiovascular diseases are the leading causes of mortality in patients with chronic kidney disease. Nitric oxide has a critical role in both endothelial dysfunction and the atherosclerosis process. We aimed to investigate the relationships between serum asymmetric dimethyl arginine (ADMA), LOX-1, and Apelin-13 levels, which are known to act over nitric oxide with endothelial dysfunction and cardiac morphology as well as with each other in hemodialysis patients. The study comprised a total of 120 patients (53 females and 67 males) receiving hemodialysis three times a week for at least 6 months and an age-gender matched control group (55 females and 58 males)...
December 4, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29195136/oxidized-ldl-triggers-changes-in-oxidative-stress-and-inflammatory-biomarkers-in-human-macrophages
#3
Oscar J Lara-Guzmán, Ángel Gil-Izquierdo, Sonia Medina, Edison Osorio, Rafael Álvarez-Quintero, Natalia Zuluaga, Camille Oger, Jean-Marie Galano, Thierry Durand, Katalina Muñoz-Durango
Oxidized low-density lipoprotein (oxLDL) is a well-recognized proatherogenic particle that functions in atherosclerosis. In this study, we established conditions to generate human oxLDL, characterized according to the grade of lipid and protein oxidation, particle size and oxylipin content. The induction effect of the cellular proatherogenic response was assessed in foam cells by using an oxLDL-macrophage interaction model. Uptake of oxLDL, reactive oxygen species production and expression of oxLDL receptors (CD36, SR-A and LOX-1) were significantly increased in THP-1 macrophages...
November 22, 2017: Redox Biology
https://www.readbyqxmd.com/read/29180444/pcsk9-deficiency-reduces-atherosclerosis-apolipoprotein-b-secretion-and-endothelial-dysfunction
#4
Hua Sun, Ronald M Krauss, Jeffrey T Chang, Ba-Bie Teng
OBJECTIVE: Proprotein convertase subtilisin kexin type 9 (PCSK9) interacts directly with cytoplasmic apolipoprotein B (apoB) and prevents its degradation via the autophagosome/lysosome pathway. This process affects VLDL and LDL production and influences atherogenesis. Here, we investigated the molecular machinery by which PCSK9 modulates autophagy and affects atherogenesis. Approach and Results: We backcrossed Pcsk9-/- mice with atherosclerosis prone LDb (Ldlr-/-Apobec1-/-) mice to generate LTp (Ldlr-/-Apobec1-/-Pcsk9-/-)...
November 27, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/29177670/molecular-chaperone-receptors
#5
Ayesha Murshid, Jimmy Theriault, Jianlin Gong, Stuart K Calderwood
Extracellular heat shock proteins (HSP) play important roles in cell signaling and immunity. Many of these effects are mediated by surface receptors expressed on a wide range of cell types. We have investigated the nature of such proteins by cloning candidate receptors into cells (CHO-K1) with the rare property of being null for HSP binding. Using this approach we have discovered that Hsp70 binds avidly to at least two classes of receptors including: (1) c-type lectin receptors (CLR) and (2) scavenger receptors (SR)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29177613/retinal-pigment-epithelium-and-photoreceptor-preconditioning-protection-requires-docosanoid-signaling
#6
Eric J Knott, William C Gordon, Bokkyoo Jun, Khanh Do, Nicolas G Bazan
Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) are necessary for functional cell integrity. Preconditioning (PC), as we define it, is an acquired protection or resilience by a cell, tissue, or organ to a lethal stimulus enabled by a previous sublethal stressor or stimulus. In this study, we provide evidence that the omega-3 fatty acid docosahexaenoic acid (DHA) and its derivatives, the docosanoids 17-hydroxy docosahexaenoic acid (17-HDHA) and neuroprotectin D1 (NPD1), facilitate cell survival in both in vitro and in vivo models of retinal PC...
November 24, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29168159/lox-1-is-a-poor-prognostic-indicator-and-induces-epithelial-mesenchymal-transition-and-metastasis-in-pancreatic-cancer-patients
#7
Jie Zhang, Lei Zhang, Can Li, Caiting Yang, Lili Li, Shushu Song, Hao Wu, Fenglin Liu, Lan Wang, Jianxin Gu
PURPOSE: Pancreatic cancer (PC) is an aggressive type of cancer that exhibits a rapid progression. Previously LOX-1, which is a type II trans-membrane glycoprotein that is expressed in endothelial cells, has been found to be involved in the development of several types of cancer. As yet, however, the expression of LOX-1 and its functional consequences in PC have not been documented. The present study was aimed at investigating the prognostic relevance of LOX-1 expression in PC patients and at resolving its role in PC metastasis...
November 22, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29124655/enhanced-bioactivity-of-the-anti-lox-1-scfv-engineered-by-multimerization-strategy
#8
Wei Hu, Qiuhong Xie, Ling Liu, Hongyu Xiang
Single-chain variable fragment (scFv) antibodies as therapeutic agents have the potential to reduce the production cost and immunogenicity relative to monoclonal antibodies, but their monovalency and lack of a fragment crystallizable region can lead to reduced function. Multimerization is one strategy for recovering the function; however, their application is limited by the production of multimeric proteins. In our previous study, an anti-lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) scFv showed potential use in diagnosis and therapy of atherosclerotic diseases, but is limited by its inherent low antigen-binding activity...
November 9, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29118901/impacts-of-berberine-on-oxidized-ldl-induced-proliferation-of-human-umbilical-vein-endothelial-cells
#9
Rui-Xia Xu, Xian-Chang Sun, Chun-Yan Ma, Yu-Hong Yao, Xiao-Lin Li, Yuan-Lin Guo, Yan Zhang, Sha Li, Jian-Jun Li
Berberine (BBR), a Chinese medicine extracted from natural plant, has been demonstrated to improve lipid disorders. Oxidized low-density lipoprotein (oxLDL), a proatherogenic lipoprotein, has been shown to be involved in vascular endothelial cell dysfunction such as excessive or abnormal proliferation. The purpose of the present study was to investigate the impacts of BBR on cell proliferations as well as potential involving signal pathways. HUVECs were stimulated with oxLDL and co-cultured with BBR at a variety of concentrations in different time points...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29115480/protective-effects-of-probucol-on-ox-ldl-induced-epithelial-mesenchymal-transition-in-human-renal-proximal-tubular-epithelial-cells-via-lox%C3%A2-1-ros-mapk-signaling
#10
Bing Bing Zhu, Hao Wang, Yang Feng Chi, Yun Man Wang, Xing Mei Yao, Shuang Liu, Huiling Qiu, Ji Fang, Pei Hao Yin, Xue Mei Zhang, Wen Peng
Oxidized low-density lipoprotein (Ox-LDL), as a strong oxidant, results in renal injury through multiple mechanisms. The aim of the present study was to determine the injury effects of Ox‑LDL and the potential protective effects of the antioxidant reagent probucol on epithelial‑mesenchymal transition (EMT) in human renal proximal tubular epithelial cells (HK‑2) and to further explore the role and interrelation of lectin‑like oxidized low‑density lipoprotein receptor‑1 (LOX‑1), reactive oxygen species (ROS) and mitogen‑activated protein kinase (MAPK) pathway...
November 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29113088/oxidative-stress-in-cardiovascular-diseases-involvement-of-nrf2-antioxidant-redox-signaling-in-macrophage-foam-cells-formation
#11
REVIEW
Bee Kee Ooi, Bey Hing Goh, Wei Hsum Yap
Oxidative stress is an important risk factor contributing to the pathogenesis of cardiovascular diseases. Oxidative stress that results from excessive reactive oxygen species (ROS) production accounts for impaired endothelial function, a process which promotes atherosclerotic lesion or fatty streaks formation (foam cells). Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor involved in cellular redox homeostasis. Upon exposure to oxidative stress, Nrf2 is dissociated from its inhibitor Keap-1 and translocated into the nucleus, where it results in the transcriptional activation of cell defense genes...
November 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29107109/lox-1-activation-by-oxldl-triggers-an-epithelial-mesenchymal-transition-and-promotes-tumorigenic-potential-in-prostate-cancer-cells
#12
I González-Chavarría, E Fernandez, N Gutierrez, E E González-Horta, F Sandoval, P Cifuentes, C Castillo, R Cerro, O Sanchez, Jorge R Toledo
Obesity is related to an increased risk of developing prostate cancer with high malignancy stages or metastasis. Recent results demonstrated that LOX-1, a receptor associated with obesity and atherosclerosis, is overexpressed in advanced and metastatic prostate cancer. Furthermore, high levels of oxLDL, the main ligand for LOX-1, have been found in patients with advanced prostate cancer. However, the role of LOX-1 in prostate cancer has not been unraveled completely yet. Here, we show that LOX-1 is overexpressed in prostate cancer cells and its activation by oxLDL promotes an epithelial to mesenchymal transition, through of lowered expression of epithelial markers (E-cadherin and plakoglobin) and an increased expression of mesenchymal markers (vimentin, N-cadherin, snail, slug, MMP-2 and MMP-9)...
November 14, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29103984/olr1-scavenger-receptor-knockdown-affects-mitotic-gene-expression-but-is-dispensable-for-oxidized-phospholipid-mediated-stress-signaling-in-sz-95-sebocytes
#13
Ionela-Mariana Nagelreiter, Masomeh Parvardeh, Marie-Sophie Narzt, Lucian Beer, Christopher Kremslehner, Ximena Maria Muresan, Johannes Grillari, Christos C Zouboulis, Erwin Tschachler, Florian Gruber
Phospholipid oxidation products (OxPL) are versatile stress signaling mediators in the skin. These lipid signaling molecules can be generated non-enzymatically or enzymatically by ultraviolet light, the major extrinsic skin aging factor. OxPL regulate cytoprotective, immunological and metabolic adaptation of the skin to oxidant stress. We here investigated whether the scavenger receptor Oxidized Low Density Lipoprotein Receptor 1 (OLR1, LOX-1) would have a function in cutaneous oxPL signaling. We found, that OLR1 is expressed in several cutaneous cell types, most prominently in cells of the sebaceous gland and in keratinocytes...
November 2, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29096854/lectin-like-oxidized-low-density-lipoprotein-receptor-1-promotes-endothelial-dysfunction-in-ldl-receptor-knockout-background
#14
Anja Hofmann, Coy Brunssen, David M Poitz, Heike Langbein, Ruth H Strasser, Thomas Henle, Ursula Ravens, Henning Morawietz
OBJECTIVE: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the major receptor for oxidized LDL in endothelial cells. LOX-1 is highly expressed in atherosclerotic plaques. The impact of LOX-1 on development of endothelial dysfunction in large vessels in absence or presence of atherosclerosis-prone conditions has not been studied to date. METHODS: Mice with endothelial cell-specific LOX-1 overexpression (bLOX-1tg) were analyzed. Wild-type (WT) mice served as controls...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29095817/a-regulatory-role-for-%C3%AE-adrenergic-receptors-regarding-the-resolvin-d1-rvd1-pathway-in-the-diabetic-retina
#15
Haoshen Shi, Thomas W Carion, Youde Jiang, Adam Chahine, Jena J Steinle, Elizabeth A Berger
Diabetic retinopathy is a visually debilitating disease with limited treatment options available. Compound 49b, a β-adrenergic receptor agonist, has been demonstrated to effectively reduce disease pathogenesis associated with diabetic retinopathy. While the exact mechanisms are not fully understood, previous studies have determined that it reduces the pro-inflammatory cytokine, TNF-α, and inhibits apoptosis of the retinal microvasculture. As inflammation becomes more recognized in driving disease pathogenesis, so does the regulation by pro-resolving pathways as therapeutic points of intervention...
2017: PloS One
https://www.readbyqxmd.com/read/29094051/improved-scfv-anti-lox-1-binding-activity-by-fusion-with-lox-1-binding-peptides
#16
Wei Hu, Qiuhong Xie, Hongyu Xiang
The oxidized low-density lipoprotein receptor-1 (LOX-1) targeted single-chain variable fragment (scFvs) is a promising molecule for the targeted delivery of imaging and therapeutic molecules of atherosclerotic diseases; however, its applications are limited by the inherent low antigen affinity. In this study, the three-dimensional (3D) model of the anti-LOX-1 scFv was constructed and its docking with the LOX-1 protein was developed. To improve the LOX-1-binding activity, the anti-LOX-1 scFv was designed to fuse with one of three LOX-1-binding heptapeptides, LTPATAI, FQTPPQL, and LSIPPKA, at its N-terminus and C-terminus and in the linker region, which have different LOX-1-binding interfaces with the anti-LOX-1 scFv analyzed by an array of computational approaches...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29078142/electronegative-l5-ldl-induces-the-production-of-g-csf-and-gm-csf-in-human-macrophages-through-lox-1-involving-nf-%C3%AE%C2%BAb-and-erk2-activation
#17
Tzu-Ching Yang, Po-Yuan Chang, Tzu-Ling Kuo, Shao-Chun Lu
BACKGROUND AND AIMS: Circulating levels of granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF) are associated with the severity of acute myocardial infarction (AMI). However, what causes increases in G-CSF and GM-CSF is unclear. In this study, we investigated whether L5-low-density lipoprotein (LDL), a mildly oxidized LDL from AMI, can induce G-CSF and GM-CSF production in human macrophages. METHODS: L1-LDL and L5-LDL were isolated through anion-exchange chromatography from AMI plasma...
October 14, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29073573/exposure-to-traffic-generated-air-pollutants-mediates-alterations-in-brain-microvascular-integrity-in-wildtype-mice-on-a-high-fat-diet
#18
Usa Suwannasual, JoAnn Lucero, Jacob D McDonald, Amie K Lund
Air pollution-exposure is associated with detrimental outcomes in the central nervous system (CNS) such as cerebrovascular disorders, including stroke, and neurodegenerative diseases. While the mechanisms of these CNS-related outcomes involved have not been fully elucidated, exposure to traffic-generated air pollutants has been associated with altered blood brain barrier (BBB) integrity and permeability. The current study investigated whether inhalation exposure to mixed vehicle emissions (MVE) alters cerebral microvascular integrity in healthy 3 mo old C57BL/6 mice, as well as whether exposure-mediated effects were exacerbated by a high-fat (HF) vs...
October 23, 2017: Environmental Research
https://www.readbyqxmd.com/read/29069578/lox-1-mediated-phenotypic-switching-of-pulmonary-arterial-smooth-muscle-cells-contributes-to-hypoxic-pulmonary-hypertension
#19
Weifang Zhang, Tiantian Zhu, Weihua Wu, Xiaoyue Ge, Xiaoming Xiong, Zheng Zhang, Changping Hu
In pulmonary hypertension (PH), pulmonary arterial smooth muscle cells (PASMCs) are dedifferentiated, undergoing a contractile-to-synthetic phenotypic switching. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays diverse roles in the cardiovascular system, but its contribution to PH remains to be fully defined. The present study was undertaken to explore the role of LOX-1 in PASMCs dedifferentiation in hypoxia-induced pulmonary vascular remodeling and PH. In a rat model of hypoxic PH, pulmonary vascular remodeling was accompanied by increased expression of LOX-1 in pulmonary arteries...
October 22, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29056472/contribution-of-lectin-like-oxidized-low-density-lipoprotein-receptor-1-and-lox-1-modulating-compounds-to-vascular-diseases
#20
REVIEW
Anja Hofmann, Coy Brunssen, Henning Morawietz
The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the major receptor for binding and uptake of oxidized low-density lipoprotein (oxLDL) in endothelial cells. LOX-1 is also expressed in macrophages, smooth muscle cells and platelets. Following internalization of oxLDL, LOX-1 initiates a vicious cycle from activation of pro-inflammatory signaling pathways, thus promoting an increased reactive oxygen species formation and secretion of pro-inflammatory cytokines. LOX-1 plays a pivotal role in the development of endothelial dysfunction, foam cell and advanced lesions formation as well as in myocardial ischemia...
October 19, 2017: Vascular Pharmacology
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