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https://www.readbyqxmd.com/read/28724635/heterodimers-of-the-transcriptional-factors-nfatc3-and-fosb-mediate-tissue-factor-expression-for-15-s-hydroxyeicosatetraenoic-acid-induced-monocyte-trafficking
#1
Sivareddy Kotla, Nikhlesh K Singh, Daniel Kirchhofer, Gadiparthi N Rao
Tissue factor (TF) is expressed in vascular and nonvascular tissues and functions in several pathways, including embryonic development, inflammation, and cell migration. Many risk factors for atherosclerosis, including hypertension, diabetes, obesity, and smoking, increase TF expression. To better understand the TF-related mechanisms in atherosclerosis, here we investigated the role of 12/15-lipoxygenase (12/15-LOX) in TF expression. 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), the major product of human 15-LOXs 1 and 2, induced TF expression and activity in a time-dependent manner in the human monocytic cell line THP1...
July 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28721161/repeated-positive-acceleration-exposure-exacerbates-endothelial-dysfunction-in-high-fat-diet-induced-hyperlipidemic-rats
#2
Zhihui Yang, Hua Ge, Chunya Wang, Zhongdong Li, Qingjun Zhang, Jianchang Wang
INTRODUCTION: It remains unclear whether exposure to repeated positive acceleration (+Gz) can exacerbate endothelial dysfunction on the basis of hyperlipidemia. The aim of this study was to investigate the effect of repeated +Gz exposure on endothelial function in high-fat-diet-induced hyperlipidemic rats. MATERIAL AND METHODS: Male Sprague-Dawley rats were randomly divided into control, repeat +Gz exposure, high-fat diet (HFD), and +Gz + HFD groups. The rats in the +Gz group were exposed to +Gz and the rats in the HFD group were fed a diet with 2% cholesterol...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28713290/advanced-maternal-age-worsens-postpartum-vascular-function
#3
Jude S Morton, Alison S Care, Raven Kirschenman, Christy-Lynn Cooke, Sandra T Davidge
The age at which women experience their first pregnancy has increased throughout the decades. Pregnancy has an important influence on maternal short- and long-term cardiovascular outcomes. Pregnancy at an advanced maternal age increases maternal risk of gestational diabetes, preeclampsia, placenta previa and caesarian delivery; complications which predict worsened cardiovascular health in later years. Aging also independently increases the risk of cardiovascular disease; therefore, combined risk in women of advanced maternal age may lead to detrimental cardiovascular outcomes later in life...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28678158/early-hippocampal-i-ltp-and-lox-1-overexpression-induced-by-anoxia-a-potential-role-in-neurodegeneration-in-npc-mouse-model
#4
Adriana Lo Castro, Michela Murdocca, Sabina Pucci, Anna Zaratti, Chiara Greggi, Federica Sangiuolo, Virginia Tancredi, Claudio Frank, Giovanna D'Arcangelo
Niemann-Pick type C disease (NPCD) is an autosomal recessive storage disorder, characterized by abnormal sequestration of unesterified cholesterol within the late endo-lysosomal compartment of cells. In the central nervous system, hypoxic insults could result in low-density lipoprotein (LDL) oxidation and Lectin-like oxidized LDL receptor-1 (LOX-1) induction, leading to a pathological hippocampal response, namely, ischemic long-term potentiation (i-LTP). These events may correlate with the progressive neural loss observed in NPCD...
July 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28672042/syncytiotrophoblast-extracellular-vesicles-impair-rat-uterine-vascular-function-via-the-lectin-like-oxidized-ldl-receptor-1
#5
Floor Spaans, Cindy K Kao, Jude S Morton, Anita L Quon, Tatsuya Sawamura, Dionne S Tannetta, Ian L Sargent, Sandra T Davidge
Syncytiotrophoblast extracellular vesicles (STBEVs) are placenta derived particles that are released into the maternal circulation during pregnancy. Abnormal levels of STBEVs have been proposed to affect maternal vascular function. The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a multi-ligand scavenger receptor. Increased LOX-1 expression and activation has been proposed to contribute to endothelial dysfunction. As LOX-1 has various ligands, we hypothesized that, being essentially packages of lipoproteins, STBEVs are able to activate the LOX-1 receptor thereby impairing vascular function via the production of superoxide and decreased nitric oxide bioavailability...
2017: PloS One
https://www.readbyqxmd.com/read/28661206/protective-regulation-of-the-ace2-ace-gene-expression-by-estrogen-in-human-atrial-tissue-from-elderly-men
#6
A Bukowska, L Spiller, C Wolke, U Lendeckel, S Weinert, J Hoffmann, P Bornfleth, I Kutschka, A Gardemann, B Isermann, A Goette
Data from animal experiments and clinical investigations suggest that components of the renin-angiotensin system are markedly affected by sex hormones. However, whether estrogen affects human atrial myocardium has not been investigated yet. In this study, we determined the effects of estrogen on key components of atrial renin-angiotensin system: angiotensin-converting enzyme, responsible for generation of angiotensin II and angiotensin-converting enzyme 2, counteracting majority of AngII effects, and different renin-angiotensin system receptors, AT1R, AT2R, and MAS...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28657156/multiple-molecular-dynamics-simulations-of-human-lox-1-and-trp150ala-mutant-reveal-the-structural-determinants-causing-the-full-deactivation-of-the-receptor
#7
Federico Iacovelli, Fabio Giovanni Tucci, Gabriele Macari, Mattia Falconi
Multiple classical molecular dynamics simulations have been applied to the human LOX-1 receptor to clarify the role of the Trp150Ala mutation in the loss of binding activity. Results indicate that the substitution of this crucial residue, located at the dimer interface, markedly disrupts the wild type receptor dynamics. The mutation causes an irreversible rearrangement of the subunits interaction pattern that in the wild type protein allows the maintaining of a specific symmetrical motion of the monomers. The subunits dislocation determines a loss of linearity of the arginines residues composing the basic spine and a consequent alteration of the long range electrostatic attraction of the substrate...
June 28, 2017: Proteins
https://www.readbyqxmd.com/read/28642826/elucidation-of-the-role-of-lectin-like-oxldl-receptor-1-in-the-metabolic-responses-of-macrophages-to-human-oxldl
#8
Danielle W Kimmel, William P Dole, David E Cliffel
Atherogenesis is the narrowing of arteries due to plaque build-up that results in cardiovascular disease that can lead to death. The macrophage lectin-like oxidized LDL receptor-1 (LOX-1), also called the oxidized low-density lipoprotein receptor 1 (OLR1), is currently thought to aid in atherosclerotic disease progression; therefore metabolic studies have potential to both provide mechanistic validation for the role of LOX-1 in disease progression and provide valuable information regarding biomarker strategies and clinical imaging...
2017: Journal of Lipids
https://www.readbyqxmd.com/read/28601780/sirt1-inhibition-causes-oxidative-stress-and-inflammation-in-patients-with-coronary-artery-disease
#9
Shih-Hung Chan, Ching-Hsia Hung, Jhih-Yuan Shih, Pei-Ming Chu, Yung-Hsin Cheng, Huei-Chen Lin, Kun-Ling Tsai
Coronary artery disease (CAD) is the primary critical cardiovascular event. Endothelial cell and monocyte dysfunction with subsequent extravagant inflammation are the main causes of vessel damage in CAD. Thus, strategies that repress cell death and manage unsuitable pro-inflammatory responses in CAD are potential therapeutic strategies for improving the clinical prognosis of patients with CAD. SIRT1 (Sirtuin 1) plays an important role in regulating cellular physiological processes. SIRT1 is also thought to protect the cardiovascular system by means of its antioxidant, anti-inflammation and anti-apoptosis activities...
June 2, 2017: Redox Biology
https://www.readbyqxmd.com/read/28595908/association-of-angiotensin-ii-receptor-1-and-lectin-like-oxidized-low-density-lipoprotein-receptor-1-mediates-the-cardiac-hypertrophy%C3%A2-induced-by-oxidized-low-density-lipoprotein
#10
Yunzi Zhao, Yuqiu Li, Xiaohui Ning, Keping Chen, Shu Zhang
To date the molecular mechanism of cardiac hypertrophy has not been completely elucidated. Since oxidized low-density lipoprotein (ox-LDL) is considered a risk marker for early ventricular remodeling, we speculated that ox-LDL may be related to cardiac hypertrophy. We observed the significantly upregulation of plasma ox-LDL and hypertrophic responses, such as cardiomyocyte size and specific gene expressions in Apo E(-/-) mice fed with high fat diet, accompanied by the upregulation of AT1-R and lectin-like oxidized low-density protein receptor 1 (LOX-1)...
June 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28588394/the-two-row-malting-barley-cultivar-new-sachiho-golden-with-null-lipoxygenase-1-improves-flavor-stability-in-beer-and-was-developed-by-marker-assisted-selection
#11
Mika Oozeki, Toshinori Sotome, Naoto Haruyama, Masahiro Yamaguchi, Hirohisa Watanabe, Takeshi Okiyama, Tsuneo Kato, Toshiyuki Takayama, Makoto Oyama, Takashi Nagamine, Yasuo Suzuki, Takako Toyoshima, Takahiro Sekiwa, Kaori Oono, Tetsuya Saito, Masao Usui, Shin Arai, Terunobu Kumekawa, Emiko Suzuki, Kaori Shirama, Makoto Kihara, Takehiro Hoki, Hideki Matsubara, Ryo Ohsawa
Lipoxygenase-1 (LOX-1) null 'New Sachiho Golden' is a two-row malting barley (Hordeum vulgare L.) cultivar released in 2015 that was developed at the Tochigi Prefectural Agricultural Experimental Station by backcross breeding using the high-yield leading cultivar 'Sachiho Golden' as a recurrent parent and the LOX-1 null mutant 'Daikei LM1' as a non-recurrent parent. To develop 'New Sachiho Golden' we used a simple LOX activity assay and marker-assisted selection. This is the first LOX-1 null malting barley cultivar in Japan that is resistant to barley yellow mosaic virus (types I-III)...
March 2017: Breeding Science
https://www.readbyqxmd.com/read/28571642/lox-1-in-atherosclerosis-and-myocardial%C3%A2-ischemia-biology-genetics-and-modulation
#12
REVIEW
Naga Venkata K Pothineni, Sotirios K Karathanasis, Zufeng Ding, Arockiasamy Arulandu, Kottayil I Varughese, Jawahar L Mehta
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), one of the scavenger receptors for oxidized low-density lipoprotein cholesterol (ox-LDL), plays a crucial role in the uptake of ox-LDL by cells in the arterial wall. Mounting evidence suggests a role for LOX-1 in various steps of the atherosclerotic process, from initiation to plaque destabilization. Studies of the genetic structure of LOX-1 have also uncovered various genetic polymorphisms that could modulate the risk of atherosclerotic cardiovascular events...
June 6, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28565756/microrna-98-rescues-proliferation-and-alleviates-ox-ldl-induced-apoptosis-in-huvecs-by-targeting-lox-1
#13
Zhibo Chen, Mian Wang, Qiong He, Zilun Li, Yang Zhao, Wenjian Wang, Jieyi Ma, Yongxin Li, Guangqi Chang
Oxidized low-density lipoprotein (ox-LDL) is a major and critical mediator of atherosclerosis, and the underlying mechanism is thought to involve the ox-LDL-induced dysfunction of endothelial cells (ECs). MicroRNAs (miRNAs), which are a group of small non-coding RNA molecules that post-transcriptionally regulate the expression of target genes, have been associated with diverse cellular functions and the pathogenesis of various diseases, including atherosclerosis. miRNA-98 (miR-98) has been demonstrated to be involved in the regulation of cellular apoptosis; however, the role of miR-98 in ox-LDL-induced dysfunction of ECs and atherosclerosis has yet to be elucidated...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28559617/two-isoforms-of-lipoxygenase-from-mature-grains-of-pearl-millet-pennisetum-glaucum-l-r-br-purification-and-physico-chemico-kinetic-characterization
#14
Bunty Sharma, Laxman Kumar Chugh
This study describes the partial purification and characterization of lipoxygenase (LOX) from pearl millet mature grains of inbred HBL 0843-2. Two isoforms of LOX, i.e., LOX 1 and LOX 2, were purified using ammonium sulphate fractionation, gel filtration chromatography and ion exchange chromatography near homogeneity to 56 and 40 folds with yield of 28 and 24%, respectively. LOX 1 and LOX 2 having molecular masses of approximately 85 and 79 kDa, respectively were purified. LOX 1 and LOX 2 exhibited maximum activity at pH 4...
May 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28554199/recombinant-human-thioredoxin-1-protects-macrophages-from-oxidized-low-density-lipoprotein-induced-foam-cell-formation-and-cell-apoptosis
#15
Hui Zhang, Qi Liu, Jia-Le Lin, Yu Wang, Ruo-Xi Zhang, Jing-Bo Hou, Bo Yu
Oxidized low-density lipoprotein (ox-LDL)-induced macrophage foam cell formation and apoptosis play critical roles in the pathogenesis of atherosclerosis. Thioredoxin-1 (Trx) is an antioxidant that potently protects various cells from oxidative stress-induced cell death. However, the protective effect of Trx on ox-LDL-induced macrophage foam cell formation and apoptosis has not been studied. This study aims to investigate the effect of recombinant human Trx (rhTrx) on ox-LDL-stimulated RAW264.7 macrophages and elucidate the possible mechanisms...
May 30, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28546421/statins-attenuate-activation-of-the-nlrp3-inflammasome-by-oxidized-ldl-or-tnf-%C3%AE-in-vascular-endothelial-cells-through-a-pxr-dependent-mechanism
#16
Shaolan Wang, Xinya Xie, Ting Lei, Kang Zhang, Baochang Lai, Zihui Zhang, Youfei Guan, Guangmei Mao, Lei Xiao, Nanping Wang
Excessive activation of the NLRP3 inflammasome is implicated in cardiovascular diseases. Statins exert an anti-inflammatory effect independent of their cholesterol lowering effect. This study investigated the potential role of statins in the activation of the NLRP3 inflammasome in endothelial cells (ECs). Western blotting and qRT-PCR showed that oxidized-LDL (oxLDL) or tumor necrosis factor alpha (TNFα) activated the NLRP3 inflammasome in ECs. Simvastatin or mevastatin significantly suppressed the effects of oxLDL or TNFα...
May 25, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28535009/microrna-let-7g-alleviates-atherosclerosis-via-the-targeting-of-lox-1-in-vitro-and-in-vivo
#17
Mingxin Liu, Guizhou Tao, Qifeng Liu, Kun Liu, Xinchun Yang
Atherosclerosis is a chronic arterial disease and the leading cause of stroke and myocardial infarction. Micro-RNAs (miRNAs or miRs) have been reported to act as essential modulators during the progression of atherosclerosis. Although miR-let-7g has been demonstrated to contribute to maintaining endothelial function and vascular homeostasis, it is not known whether miR-let-7g exerts a therapeutic effect on experimental atherosclerosis. The aim of this study was to investigate the effects of miR-let-7g on atherosclerosis in vivo and in vitro and to explore its underlying mechanisms...
July 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28522412/athero-inflammatory-nanotherapeutics-ferulic-acid-based-poly-anhydride-ester-nanoparticles-attenuate-foam-cell-formation-by-regulating-macrophage-lipogenesis-and-reactive-oxygen-species-generation
#18
Rebecca A Chmielowski, Dalia S Abdelhamid, Jonathan J Faig, Latrisha K Petersen, Carol R Gardner, Kathryn E Uhrich, Laurie B Joseph, Prabhas V Moghe
Enhanced bioactive anti-oxidant formulations are critical for treatment of inflammatory diseases, such as atherosclerosis. A hallmark of early atherosclerosis is the uptake of oxidized low density lipoprotein (oxLDL) by macrophages, which results in foam cell and plaque formation in the arterial wall. The hypolipidemic, anti-inflammatory, and antioxidative properties of polyphenol compounds make them attractive targets for treatment of atherosclerosis. However, high concentrations of antioxidants can reverse their anti-atheroprotective properties and cause oxidative stress within the artery...
July 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28480509/oxidized-low-density-lipoprotein-stimulates-epithelial-sodium-channels-in-endothelial-cells-of-mouse-thoracic-aorta
#19
Chen Liang, Qiu-Shi Wang, Xu Yang, Na Niu, Qing-Qing Hu, Bao-Long Zhang, Ming-Ming Wu, Chang-Jiang Yu, Xiao Chen, Bin-Lin Song, Zhi-Ren Zhang, He-Ping Ma
BACKGROUND AND PURPOSE: Epithelial sodium channel (ENaC) is expressed in endothelial cells and acts as a negative modulator of vasodilation. Oxidized low-density lipoprotein (ox-LDL) is a key pathological factor in endothelial dysfunction. The present study is to examine the role of ENaC in ox-LDL-induced endothelial dysfunction and its associated signal transduction pathway. EXPERIMENTAL APPROACH: Patch-clamp techniques combined with pharmacological approaches were used to examine ENaC activity in the endothelial cells of split-open mouse thoracic aorta...
May 8, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28442661/lox-1-in-ischemic-stroke
#20
Tatsuya Sawamura, Yoshiko Fujita, Sayaka Horiuchi, Akemi Kakino
No abstract text is available yet for this article.
June 1, 2017: Journal of Atherosclerosis and Thrombosis
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