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endoscopic ultrasound pancreatic cancer

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https://www.readbyqxmd.com/read/29322406/utility-of-endoscopic-ultrasound-guided-fine-needle-aspiration-for-preclinical-evaluation-of-therapies-in-cancer
#1
William Berry, Daniel Croagh
Personalising cancer therapy is a way of improving treatment efficacy, by selecting specific treatments for patients with certain molecular changes to their tumour. This requires both molecular material to detect these targets and a preclinical disease model to demonstrate treatment efficacy. In pancreatic cancer this is problematic, as most patients present with advanced disease and are therefore ineligible for surgery. As a result, biological material derived from such patients has been excluded from all preclinical studies in personalised medicine...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29319916/1-0t-mr-guided-percutaneous-coaxial-cutting-needle-biopsy-in-pancreatic-lesion-diagnosis
#2
Chao Liu, Ligang Wang, Xiangmeng He, Yujun Xu, Dong Lu, Peipei Li, Rongbin Lv, Yong Feng, Ming Liu, Chengli Li
BACKGROUND: Pancreatic carcinoma is a common cause of cancer deaths worldwide. Biopsy is often required for the initial diagnosis of pancreatic masses. Biopsy can be performed endoscopically or percutaneously with computed tomography (CT) and ultrasound (US) guidance. MRI offers many inherent advantages over CT and US. PURPOSE/HYPOTHESIS: To prospectively evaluate the feasibility, accuracy, and safety of MRI-guided percutaneous coaxial cutting needle biopsy of pancreatic lesions using an open 1...
January 10, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29303908/progression-of-chronic-pancreatitis-to-pancreatic-cancer-is-there-a-role-of-gene-mutations-as-a-screening-tool
#3
Sumaira Rashid, Nidhi Singh, Surabhi Gupta, Safoora Rashid, Nandini Nalika, Vikas Sachdev, Chandra Sekhar Bal, Siddhartha Datta Gupta, Shyam S Chauhan, Anoop Saraya
OBJECTIVES: Early detection of pancreatic ductal adenocarcinoma still remains a challenge. Patients with chronic pancreatitis (CP) have a markedly increased risk of pancreatic cancer. Mutations in oncogenes and/or tumor suppressor genes play a role in development of pancreatic ductal adenocarcinoma. This study assessed mutations in KRAS and p53 gene in blood as a screening tool for malignant transformation in CP patients. METHODS: This was a cohort, single-center study including 294 CP patients...
January 5, 2018: Pancreas
https://www.readbyqxmd.com/read/29301828/pancreatic-juice-mutation-concentrations-can-help-predict-the-grade-of-dysplasia-in-patients-undergoing-pancreatic-surveillance
#4
Masaya Suenaga, Jun Yu, Koji Shindo, Koji Tamura, Jose Alejandro N Almario, Christopher M Zaykoski, P Dane Witmer, Shah Fesharakizadeh, Michael Borges, Anne Marie Lennon, Eun J Shin, Marcia I Canto, Michael G Goggins
Purpose: The measurement of mutations in pancreatic juice samples collected from the duodenum during endoscopic ultrasound (EUS) may improve the diagnostic evaluation of patients undergoing pancreatic surveillance. Our aim was to evaluate the accuracy of using pancreatic juice mutation concentrations to predict the presence and histologic grade of neoplasia in the pancreas.Experimental Design: Digital next-generation sequencing (NGS) of pancreatic juice DNA using a targeted 12-gene panel was performed on 67 patients undergoing pancreatic evaluation during EUS including patients with pancreatic ductal adenocarcinoma, patients who subsequently underwent pancreatic resection for precursor lesions, patients undergoing surveillance for their familial/inherited susceptibility to pancreatic cancer, and normal pancreas disease controls...
January 4, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29285688/pancreatoblastoma-an-unusual-diagnosis-in-an-adult-patient
#5
Gonçalo Nunes, Hélder Coelho, Marta Patita, Rita Barosa, Pedro Pinto Marques, Lídia Roque Ramos, Maria José Brito, Aurora Tomaz, Jorge Fonseca
The authors describe a 31-year-old man admitted due to progressive weight loss, diarrhea and massive hepatomegaly. Laboratory data showed anemia (haemoglobin 11.7 g/dl), abnormal liver tests (total bilirubin 1.4 g/dl, aspartate aminotransferase 70 U/l, alanine aminotransferase 37 U/l and alkaline phosphatase 520 U/l). Abdominal ultrasound (US) displayed a large heterogeneous liver with a segment IV 25 mm nodule. Magnetic resonance revealed a 4 cm pancreatic tail mass and several liver nodules consistent with metastasis...
December 28, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29213025/-a-case-of-non-invasive-ipmc-with-fibrotic-lesion-like-tubular-complex
#6
Yasuaki Abe, Kenji Kimura, Hiromune Shimamura, Kazunori Takeda, Hiroyoshi Suzuki, Junko Sakurada, Kazuyuki Ishida, Katsuaki Ukai
A 73-year-old man was incidentally diagnosed with a cystic lesion in the pancreatic body. Ultrasonography, abdominal computed tomography, magnetic resonance imaging, endoscopic retrograde cholangiopancreatography, and endoscopic ultrasound were performed, and a nodule was detected in the cystic lesion along with an irregularity of the main pancreatic duct. An initial diagnosis of a mixed-type intraductal papillary mucinous neoplasm was made, and a central pancreatectomy was performed. However, the final diagnosis was altered to non-invasive intraductal papillary mucinous carcinoma (IPMC)...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29212734/predictors-of-response-and-survival-in-locally-advanced-adenocarcinoma-of-the-pancreas-following-neoadjuvant-gtx-with-or-without-radiation-therapy
#7
William H Sherman, Elizabeth Hecht, David Leung, Kyung Chu
LESSONS LEARNED: There is no presenting parameter that predicts the success of neoadjuvant therapy for pancreatic cancer.Despite the images on scans following neoadjuvant therapy, all patients should be evaluated, because inflammation following radiation therapy (RT) may overstate the extent of tumor and vascular involvement. BACKGROUND: In patients presenting with locally advanced pancreatic adenocarcinoma deemed unresectable by two pancreatic cancer surgeons, we analyzed presenting tumor size, extent of vascular involvement, tumor markers, response to neoadjuvant gemcitabine (G), docetaxel (T), and capecitabine (X) with or without additional chemoradiotherapy with GX on R0 resection rates (≥2 mm margins), and survival...
December 6, 2017: Oncologist
https://www.readbyqxmd.com/read/29191275/screening-of-patients-at-risk-for-familial-pancreatic-cancer-what-is-bene%C3%AF-cial
#8
REVIEW
Robert J Torphy, Richard D Schulick
Family history is a significant risk factor for developing pancreatic cancer and this hereditary risk can be secondary to familial cancer predisposition syndromes, hereditary pancreatitis, or familial pancreatic cancer. Certain high-risk individuals are recommended to undergo screening for pancreatic cancer with endoscopic ultrasound or MRI/magnetic resonance retrograde cholangiopancreatography because of the potential to identify and curatively resect precursor lesions. The management of suspicious lesions identified on screening high-risk individuals is also discussed...
February 2018: Surgical Clinics of North America
https://www.readbyqxmd.com/read/29186684/pancreatic-adenocarcinoma-therapeutic-targets-revealed-by-tumor-stroma-cross-talk-analyses-in-patient-derived-xenografts
#9
Rémy Nicolle, Yuna Blum, Laetitia Marisa, Celine Loncle, Odile Gayet, Vincent Moutardier, Olivier Turrini, Marc Giovannini, Benjamin Bian, Martin Bigonnet, Marion Rubis, Nabila Elarouci, Lucile Armenoult, Mira Ayadi, Pauline Duconseil, Mohamed Gasmi, Mehdi Ouaissi, Aurélie Maignan, Gwen Lomberk, Jean-Marie Boher, Jacques Ewald, Erwan Bories, Jonathan Garnier, Anthony Goncalves, Flora Poizat, Jean-Luc Raoul, Veronique Secq, Stephane Garcia, Philippe Grandval, Marine Barraud-Blanc, Emmanuelle Norguet, Marine Gilabert, Jean-Robert Delpero, Julie Roques, Ezequiel Calvo, Fabienne Guillaumond, Sophie Vasseur, Raul Urrutia, Aurélien de Reyniès, Nelson Dusetti, Juan Iovanna
Preclinical models based on patient-derived xenografts have remarkable specificity in distinguishing transformed human tumor cells from non-transformed murine stromal cells computationally. We obtained 29 pancreatic ductal adenocarcinoma (PDAC) xenografts from either resectable or non-resectable patients (surgery and endoscopic ultrasound-guided fine-needle aspirate, respectively). Extensive multiomic profiling revealed two subtypes with distinct clinical outcomes. These subtypes uncovered specific alterations in DNA methylation and transcription as well as in signaling pathways involved in tumor-stromal cross-talk...
November 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/29174773/the-diagnosis-and-staging-of-pancreatic-cancer-a-comparison-of-endoscopic-ultrasound-and-computed-tomography-with-pancreas-protocol
#10
Tianli Du, Katherine A Bill, Jennifer Ford, Mohammed Barawi, Richard D Hayward, Amer Alame, Richard N Berri
BACKGROUND: Pancreatic cancer is the fourth leading cause of cancer-related death in United States. We compared Computed Tomography (CT) with pancreas protocol and Endoscopic Ultrasound (EUS) in terms of mass detection, mass size, vascular involvement and lymph node involvement. METHODS: We retrospectively evaluated 93 patients. Concordance between CT and EUS, and accuracy of CT and EUS were assessed using a retrospective chart review and statistical analysis. RESULTS: CT and EUS agreed on mass detection in 88% of the cases and mass size in 67% of the cases...
November 21, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29173872/application-of-intraoperative-transluminal-core-biopsy-for-diagnosis-of-pancreatic-head-mass-a-single-center-15-year-experience
#11
Jianmin Chen, Kuirong Jiang, Junli Wu, Wentao Gao, Qiang Li, Feng Guo, Jishu Wei, Zipeng Lu, Min Tu, Chunhua Xi, Cuncai Dai, Yi Miao
BACKGROUND: Pathology is the gold standard for diagnosis of pancreatic cancer. Preoperative endoscopic ultrasound-guided biopsy is an expensive procedure that is not routine in developing countries, hence a cheap, reliable alternative is required. AIM: To evaluate the effectiveness and safety of a new technique of intraoperative biopsy from pancreatic head mass. METHODS: Patients undergoing intraoperative transluminal core-biopsy (TLCB) for pancreatic head mass from January 2000 to June 2015 were included in this study...
September 4, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29170051/multicenter-study-of-early-pancreatic-cancer-in-japan
#12
Atsushi Kanno, Atsushi Masamune, Keiji Hanada, Hiroyuki Maguchi, Yasuhiro Shimizu, Toshiharu Ueki, Osamu Hasebe, Takao Ohtsuka, Masafumi Nakamura, Mamoru Takenaka, Masayuki Kitano, Masataka Kikuyama, Toshifumi Gabata, Koji Yoshida, Tamito Sasaki, Masahiro Serikawa, Toru Furukawa, Akio Yanagisawa, Tooru Shimosegawa
BACKGROUND/OBJECTIVES: The diagnosis of early-stage pancreatic ductal adenocarcinoma (PDAC) is still challenging. We conducted a multicenter study to clarify the clinical features of early-stage PDAC in Japan. METHODS: We collected patients with stage 0 and stage I PDAC according to the sixth edition of the Japanese Classification of Pancreatic Carcinoma. We retrospectively analyzed the clinical profiles including opportunities for medical examination, imaging modalities and findings, methods of cytological diagnosis, and prognosis according to the stages at diagnosis...
November 20, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29166170/highly-accurate-identification-of-cystic-precursor-lesions-of-pancreatic-cancer-through-targeted-mass-spectrometry-a-phase-iic-diagnostic-study
#13
Karolina S Jabbar, Liisa Arike, Caroline S Verbeke, Riadh Sadik, Gunnar C Hansson
Purpose Pancreatic cystic lesions are common incidental findings on imaging, but up to half may be forerunners of pancreatic cancer. Therefore, accurate differential diagnosis is crucial for correct patient management. Unfortunately, currently available diagnostic methods cannot robustly identify premalignant and malignant pancreatic cystic lesions. Methods Cyst fluid samples obtained by routine endoscopic ultrasound-guided aspiration were used for the analyses. In a cohort of 24 patients, eight biomarker candidates for malignant potential and high-grade dysplasia/cancer were identified by an explorative proteomic approach...
November 22, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29151953/pancreatic-cancer-in-lynch-syndrome-patients
#14
REVIEW
Luis Bujanda, Marta Herreros-Villanueva
Although colorectal cancer (CRC) is the most common cancer type in Lynch syndrome (LS) families, patients have also increased lifetime risk of other types of tumors. The accumulated risk of pancreatic cancer (PC) in LS patients is around 3.7% and developed tumors often present a characteristically medullary appearance with prominent lymphocytic infiltration. LS patients are considered in high risk for PC development as they present 8.6-fold increase compared with the general population. Here we review PC cases reported in LS patients and current management guidelines...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29151511/an-intrapancreatic-accessory-spleen-that-was-difficult-to-diagnose-due-to-temporal-changes-after-splenectomy
#15
Daisuke Uchida, Koichiro Tsutsumi, Hironari Kato, Hiroyuki Okada
Accessory spleen (AS) is common anomaly, and 20% of AS cases occur in the pancreatic tail(1). An intrapancreatic AS can be difficult to distinguish from pancreatic neoplasms. In most cases, an AS is described as a hypervascular and solitary tumor, but an AS sometimes takes other forms. We herein report a rare case of an intrapancreatic AS with temporal changes in its appearance after splenectomy, which mimicked aspects of pancreatic cancer. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and Tc-99m sulfur colloid scintigraphy were useful for the diagnosis...
November 20, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29116342/gastroenterology-and-pancreatic-adenocarcinoma-what-the-radiologist-needs-to-know
#16
Abhik Bhattacharya, Namita S Gandhi, Mark E Baker, Prabhleen Chahal
In this article, we review the information that radiologists need to know regarding the endoscopic approach to the diagnosis and management of pancreatic cancer. This includes a review of the indications, techniques, and complications of endoscopic ultrasound. We also review information regarding endoscopic retrograde cholangiopancreatography, including the various biliary drainage techniques and the use of endoscopic palliation for patients with pancreatic cancer.
November 7, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29101607/development-of-a-high-risk-pancreatic-screening-clinic-using-3-0%C3%A2-t-mri
#17
Chad A Barnes, Elizabeth Krzywda, Shannon Lahiff, Dena McDowell, Kathleen K Christians, Paul Knechtges, Parag Tolat, Mark Hohenwalter, Kulwinder Dua, Abdul H Khan, Douglas B Evans, Jennifer Geurts, Susan Tsai
Selective screening for pancreatic cancer (PC) has been proposed. We describe the establishment of a comprehensive multidisciplinary screening program using 3.0 T MRI. Criteria for screening included the presence of PC in: ≥ 2 first degree relatives (FDR), 1 FDR and 1 s degree relative (SDR), ≥ 3 any degree relatives (ADR), or any known hereditary cancer syndrome with increased PC risk. Imaging with 3.0 T MRI was performed routinely and endoscopic ultrasound was used selectively. Screening was completed in 75 patients (pts)...
November 3, 2017: Familial Cancer
https://www.readbyqxmd.com/read/29081794/eus-morphology-is-reliable-in-selecting-patients-with-mucinous-pancreatic-cyst-s-most-likely-to-benefit-from-surgical-resection
#18
Siddharth Javia, Satish Munigala, Sushovan Guha, Banke Agarwal
BACKGROUND AND STUDY AIMS: Endoscopic ultrasound (EUS) surveillance of patients with mucinous pancreatic cysts relies on the assessment of morphologic features suggestive of malignant transformation. These criteria were derived from the evaluation of surgical pathology in patients with pancreatic cysts who underwent surgery. Reliability of these criteria when evaluated by EUS in identifying lesions which require surgery has still not been established. PATIENTS AND METHODS: This retrospective cohort study included seventy-eight patients who underwent surgical resection of pancreatic cysts based on EUS-FNA (fine-needle aspiration) findings suggestive of mucinous pancreatic cysts with concern for malignancy...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29070996/pancreatic-adenocarcinoma-masquerading-as-idiopathic-chronic-pancreatitis-with-delayed-diagnosis
#19
Sunil Badami, Htay Htay Kyi, Sunil Upadhaya, Samer Al Hadidi
Pancreatic cancer carries poor prognosis. Establishing the diagnosis early could help in improving outcome. We are presenting a case of pancreatic cancer with delayed diagnosis. Our 60-year-old patient underwent multiple endoscopic ultrasound-guided biopsies with no evidence of malignancy. He had normal molecular tumor biomarkers. The patient needed 8 months to receive the diagnosis and initiate the treatment. There are no specific guidelines regarding choice of tissue sampling modalities in such cases.
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29065734/comparison-of-22-gauge-standard-fine-needle-versus-core-biopsy-needle-for-endoscopic-ultrasound-guided-sampling-of-suspected-pancreatic-cancer-a-randomized-crossover-trial
#20
Dong Hyo Noh, Kyu Choi, Seonhye Gu, Juhee Cho, Kee-Taek Jang, Young Sik Woo, Kyu Taek Lee, Jong Kyun Lee, Kwang Hyuck Lee
BACKGROUND: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is effective for tissue diagnosis of pancreatic mass. To improve diagnostic yield and drawbacks, 22-gauge (G) core biopsy (FNB) needle has been developed. This study aims to compare 22G FNA and FNB needles for EUS-guided sampling of suspected pancreatic cancer. METHODS: This is a randomized controlled crossover trial. A total of 60 patients with suspected unresectable pancreatic cancer referred for EUS-guided sampling were randomly assigned to two groups...
October 24, 2017: Scandinavian Journal of Gastroenterology
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