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https://www.readbyqxmd.com/read/29782967/deficient-mitochondrial-biogenesis-in-il-2-activated-nk-cells-correlates-with-impaired-pgc1-%C3%AE-upregulation-in-elderly-humans
#1
Dante Miranda, Claudia Jara, Sophia Mejias, Viviana Ahumada, Marcelo Cortez-San Martin, Jorge Ibañez, Sandra Hirsch, Margarita Montoya
Immunosenescence has been described as age-associated changes in the immune function which are thought to be responsible for the increased morbidity with age. Human Natural Killer (NK) cells are a specialized heterogeneous subpopulation of lymphocytes involved in immune defense against tumor and microbial diseases. Interestingly, aging-related NK cell dysfunction is associated with features of aging such as tumor incidence, reduced vaccination efficacy, and short survival due to infection. It is known that NK cell effector functions are critically dependent on cytokines and metabolic activity...
May 18, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29765501/peroxisomal-acyl-coa-oxidase-type-1-anti-inflammatory-and-anti-aging-properties-with-a-special-emphasis-on-studies-with-lps-and-argan-oil-as-a-model-transposable-to-aging
#2
REVIEW
Joseph Vamecq, Pierre Andreoletti, Riad El Kebbaj, Fatima-Ezzahra Saih, Norbert Latruffe, M' Hammed Saïd El Kebbaj, Gérard Lizard, Boubker Nasser, Mustapha Cherkaoui-Malki
To clarify appropriateness of current claims for health and wellness virtues of argan oil, studies were conducted in inflammatory states. LPS induces inflammation with reduction of PGC1- α signaling and energy metabolism. Argan oil protected the liver against LPS toxicity and interestingly enough preservation of peroxisomal acyl-CoA oxidase type 1 (ACOX1) activity against depression by LPS. This model of LPS-driven toxicity circumvented by argan oil along with a key anti-inflammatory role attributed to ACOX1 has been here transposed to model aging...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29739813/interleukin-1-%C3%AE-activates-a-myc-dependent-metabolic-switch-in-kidney-stromal-cells-necessary-for-progressive-tubulointerstitial-fibrosis
#3
Dario R Lemos, Michael McMurdo, Gamze Karaca, Julia Wilflingseder, Irina A Leaf, Navin Gupta, Tomoya Miyoshi, Koichiro Susa, Bryce G Johnson, Kirolous Soliman, Guanghai Wang, Ryuji Morizane, Joseph V Bonventre, Jeremy S Duffield
Background Kidney injury is characterized by persisting inflammation and fibrosis, yet mechanisms by which inflammatory signals drive fibrogenesis remain poorly defined. Methods RNA sequencing of fibrotic kidneys from patients with CKD identified a metabolic gene signature comprising loss of mitochondrial and oxidative phosphorylation gene expression with a concomitant increase in regulators and enzymes of glycolysis under the control of PGC1 α and MYC transcription factors, respectively. We modeled this metabolic switch in vivo , in experimental murine models of kidney injury, and in vitro in human kidney stromal cells (SCs) and human kidney organoids...
May 8, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29667027/neonatal-overfeeding-impairs-differentiation-potential-of-mice-subcutaneous-adipose-mesenchymal-stem-cells
#4
Isabelle Dias, Ísis Salviano, André Mencalha, Simone Nunes de Carvalho, Alessandra Alves Thole, Laís Carvalho, Erika Cortez, Ana Carolina Stumbo
Nutritional changes in the development (intrauterine life and postnatal period) may trigger long-term pathophysiological complications such as obesity and cardiovascular disease. Metabolic programming leads to organs and tissues modifications, including adipose tissue, with increased lipogenesis, production of inflammatory cytokines, and decreased glucose uptake. However, stem cells participation in adipose tissue dysfunctions triggered by overfeeding during lactation has not been elucidated. Therefore, this study was the first to evaluate the effect of metabolic programming on adipose mesenchymal stem cells (ASC) from mice submitted to overfeeding during lactation, using the litter reduction model...
April 17, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29614883/bergamottin-inhibits-adipogenesis-in-3t3-l1-cells-and-weight-regulation-in-diet-induced-obese-mice
#5
Jeong-Hyeon Ko, Dongwoo Nam, Jae-Young Um, Sang Hoon Jung, Kwang Seok Ahn
Obesity is a serious and increasing health problem worldwide, and the inhibition of adipogenesis is considered to be a potential therapeutic target for it. Bergamottin (BGM), a component of grapefruit juice, has been reported to regulate lipolysis. However, the physiological role of BGM in obesity has not been evaluated so far. In the present study, we investigated the effects of BGM on obesity in 3T3-L1 cells and in mice fed a high-fat diet (HFD). BGM inhibited adipogenic differentiation of 3T3-L1 cells along with a significant decrease in the lipid content by downregulating the expression of two critical adipogenic factors, CCAAT enhancer-binding protein-alpha (C/EBP[Formula: see text]) and peroxisome proliferator activated receptor-gamma (PPAR[Formula: see text])...
April 4, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29602395/the-role-of-peroxisome-proliferator-activated-receptor-%C3%AE-coactivator-1%C3%AE-pgc-1%C3%AE-in-kidney-disease
#6
REVIEW
Szu-Yuan Li, Katalin Susztak
Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a key transcriptional regulator of mitochondrial biogenesis and function. Several recent studies have evaluated the role of PGC-1α in various renal cell types in healthy and disease conditions. Renal tubule cells mostly depend on mitochondrial fatty acid oxidation for energy generation. A decrease in PGC-1α expression and fatty acid oxidation is commonly observed in patient samples and mouse models with acute and chronic kidney disease...
March 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29563052/insight-from-mitochondrial-functions-and-proteomics-to-understand-cardiometabolic-disorders-in-survivors-of-acute-lymphoblastic-leukemia
#7
Jade Leahy, Schohraya Spahis, Eric Bonneil, Carole Garofalo, Guy Grimard, Sophia Morel, Caroline Laverdière, Maja Krajinovic, Simon Drouin, Edgard Delvin, Daniel Sinnett, Valérie Marcil, Emile Levy
BACKGROUND: Childhood acute lymphoblastic leukemia (cALL) is the most prevalent form of cancer in children. Due to advances in treatment and therapy, young cALL subjects now achieve a 90% survival rate. However, this tremendous advance does not come without consequence since ~2/3 of cALL survivors are affected by long-term and late, severe complications. Although the metabolic syndrome is a very serious sequel of cALL, the mechanisms remain undefined. It is also surprising to note that the mitochondrion, a central organelle in metabolic functions and the main cellular energy generator, have not yet been explored...
March 18, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29524513/central-irisin-administration-affords-antidepressant-like-effect-and-modulates-neuroplasticity-related-genes-in-the-hippocampus-and-prefrontal-cortex-of-mice
#8
Aline Siteneski, Mauricio P Cunha, Vicente Lieberknecht, Francis L Pazini, Karen Gruhn, Patricia S Brocardo, Ana Lúcia S Rodrigues
Evidence has indicated that the practice of physical exercise has antidepressant effects that might be associated with irisin release and BDNF signaling. In this study we investigated the effects of the central administration of irisin or BDNF in predictive tests of antidepressant properties paralleled with the gene expression of peroxisome proliferator-activated receptor gamma co-activator 1α (PGC-1α), fibronectin type III domain-containing protein 5 (FNDC5) and brain-derived neurotrophic factor (BDNF) in the hippocampus and prefrontal cortex of mice...
June 8, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29522838/region-specific-differences-in-bioenergetic-proteins-and-protein-response-to-acute-high-fat-diet-in-brains-of-low-and-high-capacity-runner-rats
#9
Li Gan, Delin Ma, Min Li, Fu-Chen Yang, Robert S Rogers, Joshua L Wheatley, Lauren G Koch, Steven L Britton, John P Thyfault, Paige C Geiger, John A Stanford
Aerobic capacity is a strong predictor of mortality. Low capacity runner (LCR) rats exhibit reduced mitochondrial function in peripheral organs. A high fat diet (HFD) can worsen metabolic phenotype in LCR rats. Little is known about metabolic changes in the brains of these rats, however. This study examined protein markers of mitochondrial function and metabolism as a function of aerobic running capacity and an acute HFD in four brain regions: the striatum, hippocampus, hypothalamus, and substantia nigra. After 3 days HFD or chow diets, we measured peroxisome proliferator-activated receptor-γ coactivator 1α (PGC1-α), nuclear respiratory factors 1 (Nrf-1), mitochondrial transcription factor A (TFAM), and phosphorylated (activated) AMP-activated protein kinase (p-AMPK) protein levels in the four brain regions...
May 1, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29477240/increased-podocyte-sirtuin-1-function-attenuates-diabetic-kidney-injury
#10
Quan Hong, Lu Zhang, Bhaskar Das, Zhengzhe Li, Bohan Liu, Guangyan Cai, Xiangmei Chen, Peter Y Chuang, John Cijiang He, Kyung Lee
Podocyte injury and loss contribute to the progression of glomerular diseases, including diabetic kidney disease. We previously found that the glomerular expression of Sirtuin-1 (SIRT1) is reduced in human diabetic glomeruli and that the podocyte-specific loss of SIRT1 aggravated albuminuria and worsened kidney disease progression in diabetic mice. SIRT1 encodes an NAD-dependent deacetylase that modifies the activity of key transcriptional regulators affected in diabetic kidneys, including NF-κB, STAT3, p53, FOXO4, and PGC1-α...
February 22, 2018: Kidney International
https://www.readbyqxmd.com/read/29467670/zinc-%C3%AE-2-glycoprotein-is-associated-with-obesity-in-chinese-people-and-hfd-induced-obese-mice
#11
Meijuan Liu, Huijuan Zhu, Yufei Dai, Hui Pan, Naishi Li, Linjie Wang, Hongbo Yang, Kemin Yan, Fengying Gong
Zinc-α2-glycoprotein (ZAG) plays an important role in the regulation of body weight, body fat, and glucose metabolism. In this study, we first measured ZAG levels in serum and ZAG mRNA levels in subcutaneous white adipose tissue (sWAT) among overweight/obese patients and lean control subjects. Second, we investigated the effects of ZAG administration on the body weight, body fat and glucose metabolism of high-fat diet (HFD)-induced obese ICR mice and the possible mechanisms involved. The results showed that serum ZAG and mRNA levels in sWAT were significantly decreased in overweight/obese patients and that both showed a negative association with body mass index (BMI) and body weight after adjustment for age and sex...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29436167/sestrin2-facilitates-glutamine-dependent-transcription-of-pgc-1%C3%AE-and-survival-of-liver-cancer-cells-under-glucose-limitation
#12
Ashish Kumar, Sagnik Giri, Chandrima Shaha
Differential utilization of metabolites and metabolic plasticity can confer adaptation to cancer cells under metabolic stress. Glutamine is one of the vital and versatile nutrients that cancer cells consume avidly for their proliferation, and therefore mechanisms related to glutamine metabolism have been identified as targets. Recently, sestrin2 (SESN2), a stress-inducible protein, has been reported to regulate survival in glutamine-depleted cancer cells; based on this, we explored if SESN2 could regulate glutamine metabolism during glucose starvation...
April 2018: FEBS Journal
https://www.readbyqxmd.com/read/29433395/chicoric-acid-improves-heart-and-blood-responses-to-hypobaric-hypoxia-in-tibetan-yaks
#13
Hua Wu, Dan Luo, Changxing Li, Hui Zhang, A Shunxian, Yuanxin Zhang, Chao Sun
Yak is a wild bovine species living on the Qinghai Tibet Plateau that demonstrates good adaptability to the hypoxic environment. Chicoric acid, a natural phenolic compound, is known as having anti-oxidant, antiviral, anti-inflammatory and analgesic properties. However, its effect on hypoxia adaptability of yak is still unclear. In this study 40 yaks were selected that were of similar age, parity and weight, and divided into the control group and experimental groups 1, 2, 3, randomly. Results showed that chicoric acid significantly improved RBC, HGB, and WBC...
2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29415899/time-dependent-changes-in-increased-levels-of-plasma-irisin-and-muscle-pgc-1%C3%AE-and-fndc5-after-exercise-in-mice
#14
Minhui Pang, Jianwei Yang, Jiaming Rao, Haiqing Wang, Jiayi Zhang, Shengyong Wang, Xiongfei Chen, Xiaomei Dong
Exercise induces the expression of peroxisome proliferator-activated receptor gamma co-activator 1-α (PGC-1α) in skeletal muscle, which promotes the cleavage of fibronectin type III domain-containing protein 5 (FNDC5) to irisin. To explore the relationship between irisin and its regulators, we analyzed the plasma irisin levels and the muscle levels of FNDC5 and PGC-1α after exercise. Male C57BL/6J mice underwent a treadmill exercise (60% of VO2max ) for 30 min or one hour (h), and blood and gastrocnemius samples were collected before exercise (pre-exercise), immediately after exercise, and during 24-h recovery after 1-h exercise...
February 2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29413492/attenuation-of-obesity-and-insulin-resistance-by-fish-oil-supplementation-is-associated-with-improved-skeletal-muscle-mitochondrial-function-in-mice-fed-a-high-fat-diet
#15
Amanda R Martins, Amanda R Crisma, Laureane N Masi, Catia L Amaral, Gabriel N Marzuca-Nassr, Lucas H M Bomfim, Bruno G Teodoro, André L Queiroz, Tamires D A Serdan, Rosangela P Torres, Jorge Mancini-Filho, Alice C Rodrigues, Tatiana C Alba-Loureiro, Tania C Pithon-Curi, Renata Gorjao, Leonardo R Silveira, Rui Curi, Philip Newsholme, Sandro M Hirabara
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to improve insulin sensitivity and glucose homeostasis in animal models of insulin resistance, but the involved mechanisms still remain unresolved. In this study, we evaluated the effects of fish oil (FO), a source of n-3 PUFAs, on obesity, insulin resistance and muscle mitochondrial function in mice fed a high-fat diet (HFD). C57Bl/6 male mice, 8 weeks old, were divided into four groups: control diet (C), high-fat diet (H), C+FO (CFO) and H+FO (HFO)...
December 11, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29362387/effects-of-ambroxol-on-the-autophagy-lysosome-pathway-and-mitochondria-in-primary-cortical-neurons
#16
J Magalhaes, M E Gegg, A Migdalska-Richards, A H Schapira
Glucocerebrosidase (GBA1) mutations are the major genetic risk factor for Parkinson's Disease (PD). The pathogenic mechanism is still unclear, but alterations in lysosomal-autophagy processes are implicated due to reduction of mutated glucocerebrosidase (GCase) in lysosomes. Wild-type GCase activity is also decreased in sporadic PD brains. Small molecule chaperones that increase lysosomal GCase activity have potential to be disease-modifying therapies for GBA1-associated and sporadic PD. Therefore we have used mouse cortical neurons to explore the effects of the chaperone ambroxol...
January 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29361779/pgc1%C3%AE-friend-or-foe-in-cancer
#17
REVIEW
Francesca Mastropasqua, Giulia Girolimetti, Maria Shoshan
The PGC1 family (Peroxisome proliferator-activated receptor γ (PPARγ) coactivators) of transcriptional coactivators are considered master regulators of mitochondrial biogenesis and function. The PGC1α isoform is expressed especially in metabolically active tissues, such as the liver, kidneys and brain, and responds to energy-demanding situations. Given the altered and highly adaptable metabolism of tumor cells, it is of interest to investigate PGC1α in cancer. Both high and low levels of PGC1α expression have been reported to be associated with cancer and worse prognosis, and PGC1α has been attributed with oncogenic as well as tumor suppressive features...
January 22, 2018: Genes
https://www.readbyqxmd.com/read/29310734/differential-methylation-of-insulin-like-growth-factor-2-in-offspring-of-physically-active-pregnant-women
#18
M R Marshall, N Paneth, J A Gerlach, L M Mudd, L Biery, D P Ferguson, J M Pivarnik
Several studies have suggested that maternal lifestyle during pregnancy may influence long-term health of offspring by altering the offspring epigenome. Whether maternal leisure-time physical activity (LTPA) during pregnancy might have this effect is unknown. The purpose of this study was to determine the relationship between maternal LTPA during pregnancy and offspring DNA methylation. Participants were recruited from the Archive for Research on Child Health study. At enrollment, participants' demographic information and self-reported LTPA during pregnancy were determined...
January 9, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29239022/fndc5-knockdown-induced-suppression-of-mitochondrial-integrity-and-significantly-decreased-cardiac-differentiation-of-mouse-embryonic-stem-cells
#19
Shima Nazem, Farzaneh Rabiee, Kamran Ghaedi, Sadegh Babashah, Majid Sadeghizadeh, Mohammad Hossein Nasr-Esfahani
Fibronectin type III domain-containing 5 protein (Fndc5) is a glycosylated protein with elevated expression in high energy demanded tissues as heart, brain, and muscle. It has been shown that upregulation of Fndc5 is regulated by peroxisome proliferator-activated receptor-γ coactivator-1 alpha (PGC-1α), which is known as a master regulator of mitochondrial function and biogenesis. Also, our group indicated that Fndc5 expression increases gradually during cardiac differentiation of mouse embryonic stem cells (mESCs)...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29216750/pde-camp-epac-c-ebp-%C3%AE-signaling-cascade-regulates-mitochondria-biogenesis-of-tubular-epithelial-cells-in-renal-fibrosis
#20
Hao Ding, Feng Bai, Hongdi Cao, Jing Xu, Li Fang, Jining Wu, Qi Yuan, Yang Zhou, Qi Sun, Weichun He, Chunsun Dai, Ke Zen, Lei Jiang, Junwei Yang
AIMS: Cyclic adenosine 3'5'-monophosphate (cAMP) is a universal second messenger that plays an important role in intracellular signal transduction. cAMP is synthesized by adenylate cyclases from adenosine triphosphate and terminated by the phosphodiesterases (PDEs). In the present study, we investigated the role of the cAMP pathway in tubular epithelial cell mitochondrial biogenesis in the pathogenesis of renal fibrosis. RESULTS: We found that the cAMP levels were decreased in fibrotic kidney tissues, and replenishing cAMP could ameliorate tubular atrophy and extracellular matrix deposition...
February 22, 2018: Antioxidants & Redox Signaling
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