Zhen Yu, Tao Yu, Xuan Li, Weilong Lin, Xuemeng Li, Muxin Zhai, Jiancai Yin, Li Zhao, Xiaoyu Liu, Baojing Zhao, Cancan Duan, Huiru Cheng, Fen Wang, Zhaolian Wei, Yuanyuan Yang
Gestational cadmium exposure increases the risk of preeclampsia. Placenta mitophagy was activated in preeclampsia. The aim of present study was to explore the mechanism of cadmium-induced mitophagy activation and its association with preeclampsia. Mitophagy markers expression levels were detected by quantitative real-time PCR, Western blot, immunofluorescence and immunochemistry in preeclampsia placenta. JEG3 cells were treated with CdCl2 , iopanoic acid (IOP), 3-methyladenine and PGC1α SiRNA to verify mechanism of cadmium-induced mitophagy...
April 5, 2024: Ecotoxicology and Environmental Safety