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https://www.readbyqxmd.com/read/28887807/feasibility-of-multiplane-microtransoesophageal-echocardiographic-guidance-in-structural-heart-disease-transcatheter-interventions-in-adults
#1
V J Nijenhuis, A Alipour, N C Wunderlich, B J W M Rensing, G Gijsbers, J M Ten Berg, M J Suttorp, L V A Boersma, J A S van der Heyden, M J Swaans
INTRODUCTION: Structural heart interventions are guided by transoesophageal or intracardiac echocardiography (TEE/ICE). MicroTEE, developed for paediatric purposes, is smaller and therefore less invasive and traumatic, avoiding the need for general anaesthesia. We aimed to show feasibility of procedural guidance by comparing image quality of microTEE with standard TEE and ICE during adult transcatheter interventions, and assess the accuracy in obtaining left atrial appendage (LAA) measurements between the microTEE probe and standard TEE...
September 8, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28741245/the-last-frontier-transcatheter-devices-for-percutaneous-or-minimally-invasive-treatment-of-chronic-heart-failure
#2
REVIEW
V J Nijenhuis, L Sanchis, J A S van der Heyden, P Klein, B J W M Rensing, A Latib, F Maisano, J M Ten Berg, P Agostoni, M J Swaans
Heart failure has a high prevalence in the general population. Morbidity and mortality of heart failure patients remain high, despite improvements in drug therapy, implantable cardioverter-defibrillators and cardiac resynchronisation therapy. New transcatheter implantable devices have been developed to improve the treatment of heart failure. There has been a rapid development of minimally invasive or transcatheter devices used in the treatment of heart failure associated with aortic and mitral valve disease and these devices are being incorporated into routine clinical practice at a fast rate...
July 24, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28674042/a-novel-hypokalemic-alkalotic-salt-losing-tubulopathy-in-patients-with-cldn10-mutations
#3
Ernie M H F Bongers, Luke M Shelton, Susanne Milatz, Sjoerd Verkaart, Anneke P Bech, Jeroen Schoots, Elisabeth A M Cornelissen, Markus Bleich, Joost G J Hoenderop, Jack F M Wetzels, Dorien Lugtenberg, Tom Nijenhuis
Mice lacking distal tubular expression of CLDN10, the gene encoding the tight junction protein Claudin-10, show enhanced paracellular magnesium and calcium permeability and reduced sodium permeability in the thick ascending limb (TAL), leading to a urine concentrating defect. However, the function of renal Claudin-10 in humans remains undetermined. We identified and characterized CLDN10 mutations in two patients with a hypokalemic-alkalotic salt-losing nephropathy. The first patient was diagnosed with Bartter syndrome (BS) >30 years ago...
July 3, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28673086/compound-specific-and-enantioselective-stable-isotope-analysis-as-tools-to-monitor-transformation-of-hexachlorocyclohexane-hch-in-a-complex-aquifer-system
#4
Yaqing Liu, Safdar Bashir, Reiner Stollberg, Ralf Trabitzsch, Holger Weiß, Heidrun Paschke, Ivonne Nijenhuis, Hans-Hermann Richnow
Technical hexachlorocyclohexane (HCH) mixtures and Lindane (γ-HCH) have been produced in Bitterfeld-Wolfen, Germany, for about 30 years until 1982. In the vicinity of the former dump sites and production facilities, large plumes of HCHs persist within two aquifer systems. We studied the natural attenuation of HCH in these groundwater systems through a combination of enantiomeric and carbon isotope fractionation to characterize the degradation of α-HCH in the areas downstream of a former disposal and production site in Bitterfeld-Wolfen...
July 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28606890/how-to-plan-an-overlap-free-projection-on-cta-or-fluoroscopy-to-facilitate-quantitative-analysis
#5
Justin Teng, Vincent Nijenhuis, Martin Swaans, Gerald Yong, Carl Schultz
AIMS: Assessment of para-valvular aortic regurgitation remains challenging. Quantitative video-densitometry is an effective technique however overlap of the aorta and left ventricle (LV) limits feasibility. We aimed to develop and validate a method to determine an 'Overlap Free Projection' (OFP). METHODS AND RESULTS: 65 computed tomography scans of patients referred for transcatheter aortic valve implantation were analysed using 3D reconstruction to evaluate the OFP...
June 13, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28516272/uterine-artery-embolization-for-symptomatic-adenomyosis-7-year-clinical-follow-up-using-ufs-qol-questionnaire
#6
Annefleur M de Bruijn, Marieke Smink, Wouter J K Hehenkamp, Robbert J Nijenhuis, Albert J Smeets, Focco Boekkooi, Paul J H M Reuwer, Willem J Van Rooij, Paul N M Lohle
PURPOSE: The purpose of this study was to assess clinical outcomes 7 years after uterine artery embolization (UAE) in the treatment of symptomatic adenomyosis. MATERIALS AND METHODS: In this prospective cohort study, one specialized hospital in the Netherlands recruited patients with symptomatic adenomyosis or adenomyosis in combination with fibroids for UAE. The 7-year post-intervention outcomes were health-related quality of life (HRQOL), symptom severity scores (SSS), satisfaction, menopause and re-interventions...
September 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28511926/fresh-frozen-or-ambient-food-equivalents-and-their-impact-on-food-waste-generation-in-dutch-households
#7
Anke M Janssen, Mariska A Nijenhuis-de Vries, Eric P J Boer, Stefanie Kremer
In Europe, it is estimated that more than 50% of total food waste - of which most is avoidable - is generated at household level. Little attention has been paid to the impact on food waste generation of consuming food products that differ in their method of food preservation. This exploratory study surveyed product-specific possible impacts of different methods of food preservation on food waste generation in Dutch households. To this end, a food waste index was calculated to enable relative comparisons of the amounts of food waste from the same type of foods with different preservation methods on an annual basis...
May 13, 2017: Waste Management
https://www.readbyqxmd.com/read/28454583/lymphoma-intervention-live-patient-reported-outcome-feedback-and-a-web-based-self-management-intervention-for-patients-with-lymphoma-study-protocol-for-a-randomised-controlled-trial
#8
Lindy P J Arts, Lonneke V van de Poll-Franse, Sanne W van den Berg, Judith B Prins, Olga Husson, Floortje Mols, Angelique V M Brands-Nijenhuis, Lidwine Tick, Simone Oerlemans
BACKGROUND: Patients with lymphoma are at risk of experiencing adverse physical and psychosocial problems from their cancer and its treatment. Regular screening of these symptoms by the use of patient-reported outcomes (PROs) could increase timely recognition and adequate symptom management. Moreover, self-management interventions intend to enhance knowledge and skills and empower patients to better manage their disease and related problems. The objective of the Lymphoma InterVEntion (LIVE) trial is to examine whether feedback to patients on their PROs and access to a web-based, self-management intervention named Living with lymphoma will increase self-management skills and satisfaction with information, and reduce psychological distress...
April 28, 2017: Trials
https://www.readbyqxmd.com/read/28340532/a-phytochrome-derived-photoswitch-for-intracellular-transport
#9
Max Adrian, Wilco Nijenhuis, Rein I Hoogstraaten, Jelmer Willems, Lukas C Kapitein
Cells depend on the proper positioning of their organelles, suggesting that active manipulation of organelle positions can be used to explore spatial cell biology and to restore cellular defects caused by organelle misplacement. Recently, blue-light dependent recruitment of specific motors to selected organelles has been shown to alter organelle motility and positioning, but these approaches lack rapid and active reversibility. The light-dependent interaction of phytochrome B with its interacting factors has been shown to function as a photoswitch, dimerizing under red light and dissociating under far-red light...
July 21, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28340150/severe-conduction-defects-requiring-permanent-pacemaker-implantation-in-patients-with-a-new-onset-left-bundle-branch-block-after-transcatheter-aortic-valve-implantation
#10
V J Nijenhuis, V F Van Dijk, S M Chaldoupi, J C Balt, J M Ten Berg
Aims: Transcatheter aortic valve implantation (TAVI) is frequently associated with cardiac conduction defects (CCD) requiring permanent pacemaker implantation (PPI). Although new-onset left bundle branch block (LBBB) is often seen, the rate of progression to severe CCD is unclear. We aimed to find clinical and electrocardiographic (ECG) parameters associated with severe CCD requiring PPI in patients with a new-onset LBBB after TAVI and assess its effect on clinical outcome. Methods and results: All consecutive patients undergoing TAVI who developed a new-onset LBBB were retrospectively analysed...
June 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28273571/detoxification-of-1-1-2-trichloroethane-to-ethene-in-a-bioreactor-co-culture-of-dehalogenimonas-and-dehalococcoides-mccartyi-strains
#11
Siti Hatijah Mortan, Lucía Martín-González, Teresa Vicent, Gloria Caminal, Ivonne Nijenhuis, Lorenz Adrian, Ernest Marco-Urrea
1,1,2-Trichloroethane (1,1,2-TCA) is a non-flammable organic solvent and common environmental contaminant in groundwater. Organohalide-respiring bacteria are key microorganisms to remediate 1,1,2-TCA because they can gain metabolic energy during its dechlorination under anaerobic conditions. However, all current isolates produce hazardous end products such as vinyl chloride, monochloroethane or 1,2-dichloroethane that accumulate in the medium. Here, we constructed a syntrophic co-culture of Dehalogenimonas and Dehalococcoides mccartyi strains to achieve complete detoxification of 1,1,2-TCA to ethene...
February 27, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28214067/nationwide-diabetes-related-lower-extremity-amputation-rates-in-secondary-care-treated-patients-with-diabetes-in-the-netherlands-dude-7
#12
Leonie Nijenhuis-Rosien, Steven Hans Hendriks, Nanne Kleefstra, Hendricus Jozef Gerardus Bilo, Gijs Wilhelmus Diederik Landman
AIMS: To estimate the annual amputation rate in all secondary care treated patients with diabetes in the Netherlands and specifically in patients known with diabetic retinopathy. METHODS: A nationwide population-based retrospective cohort study was performed including the years 2007-2011. Data of patients were retrieved from reimbursement registries for hospital care from a nationwide insurance database including codes for diabetes, retinopathy and amputation. Traumatic amputations were excluded...
April 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28138829/metabolism-and-disposition-of-the-anticancer-quinolone-derivative-vosaroxin-a-novel-inhibitor-of-topoisomerase-ii
#13
C M Nijenhuis, L Lucas, H Rosing, A D R Huitema, M Mergui-Roelvink, G C Jamieson, J A Fox, D R Mould, J H M Schellens, J H Beijnen
Background Vosaroxin is a first-in-class anticancer quinolone derivative that is being investigated for patients with relapsed or refractory acute myeloid leukemia (AML). The primary objective of this study was to quantitatively determine the pharmacokinetics of vosaroxin and its metabolites in patients with advanced solid tumors. Methods This mass balance study investigated the pharmacokinetics (distribution, metabolism, and excretion) of vosaroxin in cancer patients after a single dose of 60 mg/m(2 14)C-vosaroxin, administered as short intravenous injection...
August 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28063041/particle-bombardment-of-ex-vivo-skin-to-deliver-dna-and-express-proteins
#14
Ena Sokol, Miranda Nijenhuis, Klaas A Sjollema, Marcel F Jonkman, Hendri H Pas, Ben N G Giepmans
Particle bombardment of gold microparticles coated with plasmids, which are accelerated to high velocity, is used for transfection of cells within tissue. Using this method, cDNA encoding proteins of interest introduced into ex vivo living human skin enables studying of proteins of interest in real time. Here, technical aspects of particle bombardment of ex vivo skin are described using green fluorescent protein (GFP) as readout for efficiency. This method can be applied on numerous tissues, including in living model animals...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27934613/complete-blood-flow-obstruction-due-to-a-distally-embolised-edwards-sapien-valve-prosthesis
#15
Vincent J Nijenhuis, Martin J Swaans, Jurrien M Ten Berg
No abstract text is available yet for this article.
December 10, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27897387/small-molecule-induced-and-cooperative-enzyme-assembly-on-a-14-3-3-scaffold
#16
Anniek den Hamer, Lenne J M Lemmens, Minke A D Nijenhuis, Christian Ottmann, Maarten Merkx, Tom F A de Greef, Luc Brunsveld
Scaffold proteins regulate cell signalling by promoting the proximity of putative interaction partners. Although they are frequently applied in cellular settings, fundamental understanding of them in terms of, amongst other factors, quantitative parameters has been lagging behind. Here we present a scaffold protein platform that is based on the native 14-3-3 dimeric protein and is controllable through the action of a small-molecule compound, thus permitting study in an in vitro setting and mathematical description...
February 1, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27895156/sildenafil-prevents-podocyte-injury-via-ppar-%C3%AE-mediated-trpc6-inhibition
#17
Ramon Sonneveld, Joost G Hoenderop, Andrea M Isidori, Carole Henique, Henry B Dijkman, Jo H Berden, Pierre-Louis Tharaux, Johan van der Vlag, Tom Nijenhuis
Transient receptor potential channel C6 (TRPC6) gain-of-function mutations and increased TRPC6 expression in podocytes induce glomerular injury and proteinuria. Sildenafil reduces TRPC6 expression and activity in nonrenal cell types, although the mechanism is unknown. Peroxisome proliferator-activated receptor γ (PPAR-γ) is a downstream target of sildenafil in the cyclic guanosine monophosphate (cGMP)-activated protein kinase G (PKG) axis. PPAR-γ agonists, like pioglitazone, appear antiproteinuric. We hypothesized that sildenafil inhibits TRPC6 expression in podocytes through PPAR-γ-dependent mechanisms, thereby counteracting podocyte injury and proteinuria...
May 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27817753/spearman-s-hypothesis-tested-comparing-saudi-arabian-children-and-adolescents-with-various-other-groups-of-children-and-adolescents-on-the-items-of-the-standard-progressive-matrices
#18
Jan Te NijenhuiS, Adel A Batterjee, Michael Van Den Hoek, Jüri Allik, Vladimir Sukhanovskiy
Spearman's hypothesis tested at the level of items states that differences between ethnic groups on the items of an IQ test are a function of the g loadings of these items, such that there are small differences between ethnic groups on items with low g loadings and large differences between ethnic groups on items with high g loadings; this has been confirmed in a limited number of studies. In this paper, Spearman's hypothesis was tested, comparing a group of Saudi children and adolescents (N=3209) with other groups of children and adolescents from Denmark, Cyprus, Croatia, Bosnia, South Africa, Estonia, Ukraine, Ireland, Russia and Chile (total N=9333)...
November 7, 2016: Journal of Biosocial Science
https://www.readbyqxmd.com/read/27802168/control-of-apico-basal-epithelial-polarity-by-the-microtubule-minus-end-binding-protein-camsap3-and-spectraplakin-acf7
#19
Ivar Noordstra, Qingyang Liu, Wilco Nijenhuis, Shasha Hua, Kai Jiang, Matthijs Baars, Sanne Remmelzwaal, Maud Martin, Lukas C Kapitein, Anna Akhmanova
The microtubule cytoskeleton regulates cell polarity by spatially organizing membrane trafficking and signaling processes. In epithelial cells, microtubules form parallel arrays aligned along the apico-basal axis, and recent work has demonstrated that the members of CAMSAP/Patronin family control apical tethering of microtubule minus ends. Here, we show that in mammalian intestinal epithelial cells, the spectraplakin ACF7 (also known as MACF1) specifically binds to CAMSAP3 and is required for the apical localization of CAMSAP3-decorated microtubule minus ends...
November 15, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27769846/a-plec-isoform-identified-in-skin-muscle-and-heart
#20
Katarzyna B Gostyńska, Henny Lemmink, Jeroen Bremer, Hendri H Pas, Miranda Nijenhuis, Peter C van den Akker, Richard J Sinke, Marcel F Jonkman, Anna M G Pasmooij
No abstract text is available yet for this article.
October 18, 2016: Journal of Investigative Dermatology
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