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Katarzyna B Gostyńska, Henny Lemmink, Jeroen Bremer, Hendri H Pas, Miranda Nijenhuis, Peter C van den Akker, Richard J Sinke, Marcel F Jonkman, Anna M G Pasmooij
No abstract text is available yet for this article.
October 18, 2016: Journal of Investigative Dermatology
V J Nijenhuis, M P Huitema, V M M Vorselaars, M J Swaans, T de Kroon, J A S van der Heyden, B J W M Rensing, R Heijmen, J M Ten Berg, M C Post
AIMS: Pulmonary hypertension (PH) is associated with mortality after transcatheter aortic valve implantation (TAVI). However, diagnosis based on tricuspid regurgitant velocity (TRV) is often inaccurate and unreliable. The updated PH guidelines introduced a PH probability grading implementing additional PH signs on transthoracic echocardiography (TTE), from which we aimed to analyse its effects on clinical outcomes in patients undergoing TAVI. METHODS AND RESULTS: We included 591 consecutive patients (mean age 80...
October 6, 2016: International Journal of Cardiology
Kevin Kuntze, Anna Kozell, Hans H Richnow, Ludwik Halicz, Ivonne Nijenhuis, Faina Gelman
The present study investigated dual carbon-bromine isotope fractionation of the common groundwater contaminant ethylene dibromide (EDB) during chemical and biological transformations, including aerobic and anaerobic biodegradation, alkaline hydrolysis, Fenton-like degradation, debromination by Zn(0) and reduced corrinoids. Significantly different correlation of carbon and bromine isotope fractionation (ΛC/Br) was observed not only for the processes following different transformation pathways, but also for abiotic and biotic processes with, the presumed, same formal chemical degradation mechanism...
September 20, 2016: Environmental Science & Technology
Maria Filippini, Alessandro Amorosi, Bruno Campo, Sara Herrero-Martìn, Ivonne Nijenhuis, Beth L Parker, Alessandro Gargini
The occurrence of vinyl chloride (VC) is often a main concern at sites contaminated with chlorinated solvents due to its high degree of toxicity and carcinogenicity. VC occurrence in aquifers is most often related to the degradation of higher chlorinated ethenes or ethanes and it is generally detected in plumes along with parent contaminants. However, specific combination of stratigraphic, hydrogeologic and geochemical conditions can enhance the degradation of parents and lead to the formation of plumes almost entirely composed of VC (i...
September 2016: Journal of Contaminant Hydrology
C M Nijenhuis, A D R Huitema, C Blank, J B A G Haanen, J V van Thienen, H Rosing, J H M Schellens, J H Beijnen
Vemurafenib is an oral tyrosine kinase inhibitor which inhibits mutated serine/threonine protein kinase B-Raf (BRAF) and is approved as monotherapy or in combination with the MEK inhibitor cobimetinib for the treatment of adult patients with BRAF V600 mutation-positive unresectable or metastatic melanoma.(1-3) Currently vemurafenib is given in a fixed dose regimen of 960 mg bi-daily (BID). The pharmacokinetics of vemurafenib was previously investigated in a phase I trial and mean steady state plasma concentration of 40 ± 20 μg/mL was found at...
July 1, 2016: Journal of Clinical Pharmacology
Ivonne Nijenhuis, Hans H Richnow
Recent development allows multi-element compound-specific isotope analysis of D, (13)C, (37)Cl and (81)Br for characterizing the degradation pathways of halogenated organic substances in the environment. The apparent kinetic isotope effect (AKIE) obtained in (bio)degradation experiments yields information on the chemical mechanism of the bond cleavage. In biochemical reactions, rate limitation such as uptake into cells, substrate transport in cells and binding to enzymes as well as equilibrium isotope effects (EIE) are modifying the observed isotope fractionation associated with the bond cleavage reactions, thus, complicating mechanistic interpretation of isotope effect...
June 25, 2016: Current Opinion in Biotechnology
Diana Puigserver, Jofre Herrero, Mònica Torres, Amparo Cortés, Ivonne Nijenhuis, Kevin Kuntze, Beth L Parker, José M Carmona
In the transition zone between aquifers and basal aquitards, the perchloroethene pools at an early time in their evolution are more recalcitrant than those elsewhere in the aquifer. The aim of this study is to demonstrate that the biodegradation of chloroethenes from aged pools (i.e., pools after decades of continuous groundwater flushing and dissolution) of perchloroethene is favored in the transition zone. A field site was selected where an aged pool exists at the bottom of a transition zone. Two boreholes were drilled to obtain sediment and groundwater samples to perform chemical, isotopic, molecular, and clone library analyses and microcosm experiments...
September 2016: Environmental Science and Pollution Research International
C M Nijenhuis, L Lucas, H Rosing, G Jamieson, J A Fox, J H M Schellens, J H Beijnen
Vosaroxin is a first-in-class anticancer quinolone derivative topoisomerase II inhibitor that is currently in development in combination with cytarabine for the treatment of acute myeloid leukemia (AML). To investigate vosaroxin pharmacokinetics (PK) in patients, liquid chromatography tandem mass spectrometry (LC-MS/MS) assays to quantify vosaroxin and the two metabolites N-desmethylvosaroxin and O-desmethylvosaroxin in human plasma and urine were developed and validated. Immediately after collection the samples were stored at -80°C...
August 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
E M Vissia, M E Giesen, S Chalavi, E R S Nijenhuis, N Draijer, B L Brand, A A T S Reinders
OBJECTIVE: The Trauma Model of dissociative identity disorder (DID) posits that DID is etiologically related to chronic neglect and physical and/or sexual abuse in childhood. In contrast, the Fantasy Model posits that DID can be simulated and is mediated by high suggestibility, fantasy proneness, and sociocultural influences. To date, these two models have not been jointly tested in individuals with DID in an empirical manner. METHOD: This study included matched groups [patients (n = 33) and controls (n = 32)] that were compared on psychological Trauma and Fantasy measures: diagnosed genuine DID (DID-G, n = 17), DID-simulating healthy controls (DID-S, n = 16), individuals with post-traumatic stress disorder (PTSD, n = 16), and healthy controls (HC, n = 16)...
August 2016: Acta Psychiatrica Scandinavica
Cynthia M Nijenhuis, Edward Hellriegel, Jos H Beijnen, Diane Hershock, Alwin D R Huitema, Luc Lucas, Marja Mergui-Roelvink, Mihaela Munteanu, Laura Rabinovich-Guilatt, Philmore Robertson, Hilde Rosing, Ofer Spiegelstein, Jan H M Schellens
Background Omacetaxine mepesuccinate is indicated in adults with chronic myeloid leukemia resistant and/or intolerant to ≥ 2 tyrosine kinase inhibitor treatments. This phase I study assessed the disposition, elimination, and safety of (14)C-omacetaxine in patients with solid tumors. Methods The study comprised a 7-days pharmacokinetic assessment followed by a treatment period of ≤ six 28-days cycles. A single subcutaneous dose of 1.25 mg/m(2) (14)C-omacetaxine was administered to six patients. Blood, urine, and feces were collected through 168 h or until radioactivity excreted within 24 h was <1 % of the dose...
October 2016: Investigational New Drugs
C M Nijenhuis, J H M Schellens, J H Beijnen
Human radiolabeled mass balance studies are performed to obtain information about the absorption, distribution, metabolism, and excretion of a drug in development. The main goals are to determine the route of elimination and major metabolic pathways. This review provides an overview of the current regulatory guidelines concerning human radiolabeled mass balance studies and discusses scientific trends seen in the last decade with a focus on mass balance studies of anticancer drugs. This paper also provides an overview of mass balance studies of anticancer agents that were executed in the last 10 years...
May 2016: Drug Metabolism Reviews
Vanessa Lünsmann, Uwe Kappelmeyer, Anja Taubert, Ivonne Nijenhuis, Martin von Bergen, Hermann J Heipieper, Jochen A Müller, Nico Jehmlich
UNLABELLED: Constructed wetlands (CWs) are successfully applied for the treatment of waters contaminated with aromatic compounds. In these systems, plants provide oxygen and root exudates to the rhizosphere and thereby stimulate microbial degradation processes. Root exudation of oxygen and organic compounds depends on photosynthetic activity and thus may show day-night fluctuations. While diurnal changes in CW effluent composition have been observed, information on respective fluctuations of bacterial activity are scarce...
July 15, 2016: Applied and Environmental Microbiology
Antje A T S Reinders, Antoon T M Willemsen, Eline M Vissia, Herry P J Vos, Johan A den Boer, Ellert R S Nijenhuis
The etiology of dissociative identity disorder (DID) remains a topic of debate. Proponents of the fantasy model and the trauma model of DID have both called for more empirical research. To this end, the current study presents new and extended data analyses of a previously published H2O positron emission tomography imaging study. This study included 29 subjects: 11 patients with DID and 10 high- and 8 low-fantasy-prone DID-simulating mentally healthy control subjects. All subjects underwent an autobiographical memory script-driven (neutral and trauma related) imagery paradigm in 2 (simulated) dissociative personality states (neutral and trauma related)...
June 2016: Journal of Nervous and Mental Disease
C M Nijenhuis, H Haverkate, H Rosing, J H M Schellens, J H Beijnen
Dabrafenib (Tafinlar(®)) and trametinib (Mekinist(®)) are registered for the treatment of patients with BRAF V600 mutation positive unresectable or metastatic melanoma. To support therapeutic drug monitoring (TDM) and clinical pharmacological trials, an assay to simultaneously quantify dabrafenib and trametinib in human plasma using liquid chromatography tandem mass spectrometry was developed and validated. Human plasma samples were collected on an outpatient base and stored at nominally -20°C. Analytes and internal standards (stable isotope labeled compounds) were extracted with TBME...
June 5, 2016: Journal of Pharmaceutical and Biomedical Analysis
Anne-Charlotte Dubbelman, Cynthia M Nijenhuis, Robert S Jansen, Hilde Rosing, Hitoshi Mizuo, Shinki Kawaguchi, David Critchley, Robert Shumaker, Jan H M Schellens, Jos H Beijnen
Lenvatinib is an oral, multiple receptor tyrosine kinase inhibitor. Preclinical drug metabolism studies showed unique metabolic pathways for lenvatinib in monkeys and rats. A human mass balance study demonstrated that lenvatinib related material is mainly excreted via feces with a small fraction as unchanged parent drug, but little is reported about its metabolic fate. The objective of the current study was to further elucidate the metabolic pathways of lenvatinib in humans and to compare these results to the metabolism in rats and monkeys...
June 2016: Investigational New Drugs
Cynthia M Nijenhuis, Luc Lucas, Hilde Rosing, Philmore Robertson, Edward T Hellriegel, Jan H M Schellens, And Jos H Beijnen
Omacetaxine mepesuccinate (hereafter referred to as omacetaxine) is a protein translation inhibitor approved by the US Food and Drug Administration for adult patients with chronic myeloid leukemia with resistance and/or intolerance to two or more tyrosine kinase inhibitors. The objective was to investigate the metabolite profile of omacetaxine in plasma, urine and faeces samples collected up to 72 h after a single 1.25-mg/m(2) subcutaneous dose of (14)C-omacetaxine in cancer patients. High-performance liquid chromatography mass spectrometry (MS) (high resolution) in combination with off-line radioactivity detection was used for metabolite identification...
March 21, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Vincent J Nijenhuis, Martin J Swaans, Jurrien M Ten Berg
No abstract text is available yet for this article.
June 2016: Revista Española de Cardiología
Monique H Vingerhoeds, Mariska A Nijenhuis-de Vries, Nienke Ruepert, Harmen van der Laan, Wender L P Bredie, Stefanie Kremer
Membrane filtration of ground, surface, or sea water by reverse osmosis results in permeate, which is almost free from minerals. Minerals may be added afterwards, not only to comply with (legal) standards and to enhance chemical stability, but also to improve the taste of drinking water made from permeate. Both the nature and the concentrations of added minerals affect the taste of the water and in turn its acceptance by consumers. The aim of this study was to examine differences in taste between various remineralised drinking waters...
May 1, 2016: Water Research
Vincent Johan Nijenhuis, Naoual Bennaghmouch, Mariella Hassell, Jan Baan, Jan Peter van Kuijk, Pierfrancesco Agostoni, Arnoud van 't Hof, Peter C Kievit, Leo Veenstra, Pim van der Harst, Ad F M van den Heuvel, Peter den Heijer, Johannes C Kelder, Vera H Deneer, Frank van der Kley, Francesco Onorati, Jean Philippe Collet, Francesco Maisano, Azeem Latib, Kurt Huber, Pieter R Stella, Jurrien M Ten Berg
BACKGROUND: Despite improving experience and techniques, ischemic and bleeding complications after transcatheter aortic valve implantation (TAVI) remain prevalent and impair survival. Current guidelines recommend the temporary addition of clopidogrel in the initial period after TAVI to prevent thromboembolic events. However, explorative studies suggest that this is associated with a higher rate of major bleeding without a decrease in thromboembolic complications. METHODS: The POPular TAVI trial is a prospective randomized, controlled, open-label multicenter clinical trial to test the hypothesis that monotherapy with aspirin or oral anticoagulation (OAC) after TAVI is safer than the addition of clopidogrel for 3 months, without compromising clinical benefit...
March 2016: American Heart Journal
Cynthia M Nijenhuis, Alwin D R Huitema, Serena Marchetti, Christian Blank, John B A G Haanen, Johannes V van Thienen, Hilde Rosing, Jan H M Schellens, Jos H Beijnen
Pharmacokinetic monitoring is increasingly becoming an important part of clinical care of tyrosine kinase inhibitor treatment. Vemurafenib is an oral tyrosine kinase inhibitor that inhibits mutated serine/threonine protein kinase B-Raf (BRAF) and is approved for the treatment of adult patients with BRAF V600 mutation-positive unresectable or metastatic melanoma. The aim of this study was to establish the relationship between dried blood spot (DBS) and plasma concentrations of vemurafenib to enable the use of DBS sampling, which is a minimally invasive form of sample collection...
October 2016: Journal of Clinical Pharmacology
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