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https://www.readbyqxmd.com/read/29740444/keratinocyte-binding-assay-identifies-anti-desmosomal-pemphigus-antibodies-where-other-tests-are-negative
#1
Federica Giurdanella, Albertine M Nijenhuis, Gilles F H Diercks, Marcel F Jonkman, Hendri H Pas
The serological diagnosis of pemphigus relies on the detection of IgG autoantibodies directed against the epithelial cell surface by indirect immunofluorescence (IIF) on monkey esophagus and against desmoglein 1 (Dsg1) and Dsg3 by ELISA. Although being highly sensitive and specific tools, discrepancies can occur. It is not uncommon that sera testing positive by ELISA give a negative result by IIF and vice versa . This brings diagnostic challenges wherein pemphigus has to be ascertained or ruled out, especially when no biopsy is available...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29611351/effects-of-sildenafil-metformin-and-simvastatin-on-adh-independent-urine-concentration-in-healthy-volunteers
#2
Anneke P Bech, Jack F M Wetzels, Tom Nijenhuis
Nephrogenic diabetes insipidus (NDI) is a rare disorder characterized by resistance of the kidney to the action of antidiuretic hormone (ADH), resulting in a decrease in the capacity of the kidney to concentrate the urine. NDI can be inherited or acquired due to, for example, chronic lithium therapy. Current treatment options are limited to attempts to lower urine output by a low-solute diet and the use of diuretics or anti-inflammatory drugs. These measures are only partially effective. Recent reports suggested that sildenafil, metformin, and simvastatin might improve ADH-independent urine concentration...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29607654/differences-between-apoe-carriers-and-non-apoe-carriers-on-neurocognitive-tests-jensen-effects
#3
Jan Te Nijenhuis, Kyu Yeong Choi, Yu Yong Choi, Jang Jae Lee, Eun Hyun Seo, Hoowon Kim, Kun Ho Lee
BACKGROUND: Being a carrier of the apolipoprotein E (APOE) ε4 allele is a clear risk factor for development of Alzheimer's disease (AD). On some neurocognitive tests, there are smaller differences between carriers and noncarriers, while other tests show larger differences. AIMS: We explore whether the size of the difference between carriers and noncarriers is a function of how well the tests measure general intelligence, so whether there are Jensen effects. METHODS: We used the method of correlated vectors on 441 Korean older adults at risk for AD and 44 with AD...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29590392/special-issue-on-anaerobic-biological-dehalogenation
#4
Christof Holliger, Ivonne Nijenhuis
No abstract text is available yet for this article.
March 24, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29575501/liquid-chromatography-isotope-ratio-mass-spectrometry-analysis-of-halogenated-benzoates-for-characterization-of-the-underlying-degradation-reaction-in-thauera-chlorobenzoica-cb-1-t
#5
Steffi Franke, Steffen Kümmel, Ivonne Nijenhuis
RATIONALE: Halogenated benzoic acids occur in the environment due to their widespread agricultural and pharmaceutical use. Compound-specific stable isotope analysis (CSIA) has developed over the last decades for investigation of in-situ transformation and reaction mechanisms of environmental pollutants amenable by gas chromatography (GC). As polar compounds are unsuitable for GC analysis we developed a method to perform liquid chromatography (LC)/CSIA for halogenated benzoates. METHODS: LC/isotope ratio mass spectrometry (IRMS) utilizing a LC-Surveyor Pump coupled to a MAT 253 isotope ratio mass spectrometer via a LC-Isolink interface was applied...
March 25, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29525062/prognostic-value-of-improved-kidney-function-after-transcatheter-aortic-valve-implantation-for-aortic-stenosis
#6
Vincent Johan Nijenhuis, Joyce Peper, Veronique M M Vorselaars, Martin J Swaans, Thom De Kroon, Jan A S Van der Heyden, Benno J W M Rensing, Robin Heijmen, Willem-Jan W Bos, Jurrien M Ten Berg
Transcatheter aortic valve implantation (TAVI) is associated with acute kidney injury (AKI), but can also improve the kidney function (IKF). We assessed the effects of kidney function changes in relation to baseline kidney function on 2-year clinical outcomes after TAVI. In total, 639 consecutive patients with aortic stenosis who underwent TAVI were stratified into 3 groups according to the ratio of serum creatinine post- to pre-TAVI: IKF (≤0.80; n = 95 [15%]), stable kidney function (0.80 to 1.5; n = 477 [75%]), and AKI (≥1...
May 15, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29468159/il-1%C3%AE-promotes-a-new-function-of-dnase-i-as-a-transcription-factor-for-the-fas-receptor-gene
#7
Dhivya Thiyagarajan, Hege L Pedersen, Natalya Seredkina, Kjersti D Horvei, Lorena Arranz, Ramon Sonneveld, Tom Nijenhuis, Johan van der Vlag, Ole P Rekvig
Recently we described that endonuclease inactive DNase I translocated into the nucleus in response to increased endogenous IL-1β expression. Here, we demonstrate impact and function of translocated DNase I in tubular cells. Effect of cytokines on expression level and nuclear localisation of DNase I and corresponding levels of Fas receptor (FasR) and IL-1β were determined by confocal microscopy, qPCR and western blot analyses, in presence or absence of siRNA against IL-1β and DNase I mRNA. Nuclear DNase I bound to the FAS promotor region as determined by chromatin immuno-precipitation analysis...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29460273/pharmacogenetic-information-in-clinical-guidelines-the-european-perspective
#8
REVIEW
Jesse J Swen, Marga Nijenhuis, Mandy van Rhenen, Nienke J de Boer-Veger, Anne-Marie Buunk, Elisa J F Houwink, Hans Mulder, Gerard A Rongen, Ron H N van Schaik, Jan van der Weide, Bob Wilffert, Vera H M Deneer, Henk-Jan Guchelaar
Surveys among pharmacists and physicians show that these healthcare professionals have successfully adopted the concept of pharmacogenomics (PGx).1-3 In addition, patients are willing to consent to participate in PGx implementation studies.4 However, the surveys also show that healthcare professionals do not frequently order or recommend a PGx test.1,2 Among others, a frequently perceived hurdle for clinical uptake of PGx is the availability of guidelines translating PGx test results into clinical actions for individual patients...
May 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29411523/first-report-of-the-use-of-long-tapered-sirolimus-eluting-coronary-stent-for-the-treatment-of-chronic-total-occlusions-with-the-hybrid-algorithm
#9
Carlo Zivelonghi, Jan P van Kuijk, Vincent Nijenhuis, Enrico Poletti, Maarten J Suttorp, Jan A S van der Heyden, Frank D Eefting, Benno J Rensing, Jurrien M Ten Berg, Lorenzo Azzalini, Floris S van den Brink, Flavio Ribichini, Antonio Colombo, José P S Henriques, Pierfrancesco Agostoni
BACKGROUND: Coronary chronic total occlusions (CTO) usually coexist with diffusely diseased coronary segments proximal and/or distal to the CTO segment. During percutaneous treatment of CTO, multiple overlapping stents are often needed to treat these long lesions. OBJECTIVES: Aim of this study is to report the first use of long, tapered coronary sirolimus-eluting stents (SES) in this setting. METHODS AND RESULTS: This is a retrospective analysis of 100 consecutive patients undergoing CTO recanalization following the hybrid algorithm...
February 7, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29385441/anaerobic-microbial-dehalogenation-and-its-key-players-in-the-contaminated-bitterfeld-wolfen-megasite
#10
Ivonne Nijenhuis, Reiner Stollberg, Ute Lechner
The megasite Bitterfeld-Wolfen is highly contaminated as a result of accidents and because of dumping of wastes from local chemical industries in the last century. A variety of contaminants including chlorinated ethenes and benzenes, hexachlorohexanes and chlorinated dioxins can still be found in the groundwater and (river) sediments. Investigations of the in situ microbial transformation of organohalides have been performed only over the last two decades at this megasite. In this review, we summarise the research on the activity of anaerobic dehalogenating bacteria at the field site in Bitterfeld-Wolfen, focusing on chlorinated ethenes, monochlorobenzene and chlorinated dioxins...
April 1, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29282709/neurodevelopmental-origins-of-abnormal-cortical-morphology-in-dissociative-identity-disorder
#11
A A T S Reinders, S Chalavi, Y R Schlumpf, E M Vissia, E R S Nijenhuis, L Jäncke, D J Veltman, C Ecker
OBJECTIVE: To examine the two constitutes of cortical volume (CV), that is, cortical thickness (CT) and surface area (SA), in individuals with dissociative identity disorder (DID) with the view of gaining important novel insights into the underlying neurobiological mechanisms mediating DID. METHODS: This study included 32 female patients with DID and 43 matched healthy controls. Between-group differences in CV, thickness, and SA, the degree of spatial overlap between differences in CT and SA, and their relative contribution to differences in regional CV were assessed using a novel spatially unbiased vertex-wise approach...
February 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29236543/rorschach-assessment-of-two-distinctive-personality-states-of-a-person-with-dissociative-identity-disorder
#12
Ellen Hartmann, Kirsten Benum
This case study used test data from a patient with Dissociative Identity Disorder (DID; American Psychiatric Association, 2013 ) to illustrate how two main personality states of the patient ("Ann" and "Ben") seemed to function. The Rorschach Performance Assessment System (R-PAS; Meyer, Viglione, Mihura, Erard, & Erdberg, 2011 ) and the Inventory of Interpersonal Problems-Circumplex (IIP-64; Horowitz, Alden, Wiggins, & Pincus, 2000 ), administered to Ann and Ben in separate settings, exposed two diverse R-PAS and IIP-64 profiles...
December 13, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/29220813/biotransformation-and-inhibition-effects-of-hexachlorocyclohexanes-during-biogas-production-from-contaminated-biomass-characterized-by-isotope-fractionation-concepts
#13
Shujuan Lian, Marcell Nikolausz, Ivonne Nijenhuis, Athaydes Francisco Leite, Hans Hermann Richnow
Hexachlorocyclohexane (HCH) production for pesticides was banned by Stockholm Convention (2009) due to its harmful and adverse effects on the environment. Despite this measure, many areas contaminated with former HCH production-waste products still require management. As a potential solution contributing to clean-up of these sites, anaerobic digestion (AD) of pesticide-contaminated biomass to produce biogas is a promising strategy. High pesticide concentrations, however, may inhibit biogas production. Therefore, laboratory-scale batch reactors were set up to investigate biogas reactor performance in presence of HCH...
November 24, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29212860/reference-values-of-renal-tubular-function-tests-are-dependent-on-age-and-kidney-function
#14
Anneke P Bech, Jack F M Wetzels, Tom Nijenhuis
Electrolyte disorders due to tubular disorders are rare, and knowledge about validated clinical diagnostic tools such as tubular function tests is sparse. Reference values for tubular function tests are based on studies with small sample size in young healthy volunteers. Patients with tubular disorders, however, frequently are older and can have a compromised renal function. We therefore evaluated four tubular function tests in individuals with different ages and renal function. We performed furosemide, thiazide, furosemide-fludrocortisone, and desmopressin tests in healthy individuals aged 18-50 years, healthy individuals aged more than 50 years and individuals with compromised renal function...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29193875/dabigatran-inhibits-intravitreal-thrombin-activity
#15
Jeroen Bastiaans, Verena C Mulder, Jan C van Meurs, Marja Smits-Te Nijenhuis, Conny van Holten-Neelen, P Martin van Hagen, Willem A Dik
PURPOSE: Proliferative vitreoretinopathy (PVR) is a vitreoretinal disorder in which retinal pigment epithelial (RPE) cell activation contributes to both formation of fibrotic retinal membranes and inflammation. Vitreous of patients with PVR contains increased thrombin activity which induces profibrotic and proinflammatory programs in RPE cells. Inhibition of intravitreal thrombin activity may thus represent a therapeutic option for PVR. In this study, we examined the capacity of the clinically available direct thrombin inhibitor dabigatran to inhibit thrombin activity in vitreous fluids...
November 30, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29186701/evaluation-of-the-hydrological-flow-paths-in-a-gravel-bed-filter-modeling-a-horizontal-subsurface-flow-wetland-by-using-a-multi-tracer-experiment
#16
Jan Birkigt, Christine Stumpp, Piotr Małoszewski, Ivonne Nijenhuis
In recent years, constructed wetland systems have become into focus as means of cost-efficient organic contaminant management. Wetland systems provide a highly reactive environment in which several removal pathways of organic chemicals may be present at the same time; however, specific elimination processes and hydraulic conditions are usually separately investigated and thus not fully understood. The flow system in a three dimensional pilot-scale horizontal subsurface constructed wetland was investigated applying a multi-tracer test combined with a mathematical model to evaluate the flow and transport processes...
April 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29175406/evaluation-of-carbon-isotope-fractionation-during-anaerobic-reductive-dehalogenation-of-chlorinated-and-brominated-benzenes
#17
Seo Yean Sohn, Kevin Kuntze, Ivonne Nijenhuis, Max M Häggblom
Compound specific stable isotope analysis (CSIA) has been established as a useful tool to evaluate in situ biodegradation. Here, CSIA was used to determine microbial dehalogenation of chloro- and bromobenzenes in microcosms derived from Hackensack River sediments. Gas chromatography-isotope ratio mass spectrometry (GC-IRMS) was used to measure carbon isotope fractionation during reductive dehalogenation of hexachlorobenzene (HCB), pentachlorobenzene (PeCB), 1,2,3,5-tetrachlorobenzene (TeCB), 1,2,3,5-tetrabromobenzene (TeBB), and 1,3,5-tribromobenzene (TriBB)...
February 2018: Chemosphere
https://www.readbyqxmd.com/read/29069488/triple-element-compound-specific-stable-isotope-analysis-of-1-2-dichloroethane-for-characterization-of-the-underlying-dehalogenation-reaction-in-two-dehalococcoides-mccartyi-strains
#18
Steffi Franke, Christina Lihl, Julian Renpenning, Martin Elsner, Ivonne Nijenhuis
Chlorinated ethanes belong to the most common groundwater and soil contaminants. Of these, 1,2-dichloroethane (1,2-DCA) is a man-made, persistent and toxic contaminant, released due to improper waste treatment at versatile production sites. This study investigated the anaerobic transformation of 1,2-DCA by Dehalococcoides mccartyi strain 195 and strain BTF08 using triple-element compound-specific stable isotope analysis of carbon, chlorine and hydrogen for the first time. Isotope fractionation patterns for carbon (εCBTF08 = -28...
December 1, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28987410/variable-dual-carbon-bromine-stable-isotope-fractionation-during-enzyme-catalyzed-reductive-dehalogenation-of-brominated-ethenes
#19
Angela Woods, Kevin Kuntze, Faina Gelman, Ludwik Halicz, Ivonne Nijenhuis
The potential of compound-specific stable isotope analysis (CSIA) to characterize biotransformation of brominated organic compounds (BOCs) was assessed and compared to chlorinated analogues. Sulfurospirillum multivorans and Desulfitobacterium hafniense PCE-S catalyzed the dehalogenation of tribromoethene (TBE) to either vinyl bromide (VB) or ethene, respectively. Significantly lower isotope fractionation was observed for TBE dehalogenation by S. multivorans (εC  = -1.3 ± 0.2‰) compared to D. hafniense (εC  = -7...
January 2018: Chemosphere
https://www.readbyqxmd.com/read/28887807/feasibility-of-multiplane-microtransoesophageal-echocardiographic-guidance-in-structural-heart-disease-transcatheter-interventions-in-adults
#20
V J Nijenhuis, A Alipour, N C Wunderlich, B J W M Rensing, G Gijsbers, J M Ten Berg, M J Suttorp, L V A Boersma, J A S van der Heyden, M J Swaans
INTRODUCTION: Structural heart interventions are guided by transoesophageal or intracardiac echocardiography (TEE/ICE). MicroTEE, developed for paediatric purposes, is smaller and therefore less invasive and traumatic, avoiding the need for general anaesthesia. We aimed to show feasibility of procedural guidance by comparing image quality of microTEE with standard TEE and ICE during adult transcatheter interventions, and assess the accuracy in obtaining left atrial appendage (LAA) measurements between the microTEE probe and standard TEE...
December 2017: Netherlands Heart Journal
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