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https://www.readbyqxmd.com/read/29733383/pde4-and-makap%C3%AE-are-nodal-organizers-of-%C3%AE-2-ars-nuclear-pka-signaling-in-cardiac-myocytes
#1
Ibrahim Bedioune, Florence Lefebvre, Patrick Lechêne, Audrey Varin, Valérie Domergue, Michael S Kapiloff, Rodolphe Fischmeister, Grégoire Vandecasteele
Aims: β1- and β2-adrenergic receptors (β-ARs) produce different acute contractile effects on the heart partly because they impact on different cytosolic pools of cAMP-dependent protein kinase (PKA). They also exert different effects on gene expression but the underlying mechanisms remain unknown. The aim of this study was to understand the mechanisms by which β1- and β2-ARs regulate nuclear PKA activity in cardiomyocytes. Methods and Results: We used cytoplasmic and nuclear targeted biosensors to examine cAMP signals and PKA activity in adult rat ventricular myocytes upon selective β1- or β2-ARs stimulation...
May 3, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29618134/melanin-concentrating-hormone-expressing-neurons-adjust-slow-wave-sleep-dynamics-to-catalyze-paradoxical-rem-sleep
#2
Christophe Varin, Pierre-Hervé Luppi, Patrice Fort
Study Objectives: Experimental studies over the last fifteen years established a role in sleep of the tuberal hypothalamic neurons that express melanin-concentrating hormone (MCH). Controversies still remain regarding their actual contribution to both slow-wave sleep (SWS) and paradoxical sleep (PS aka REM sleep) or PS alone. Methods: To address this point, we compared effects of chemogenetic activation and inhibition of MCH neurons on SWS and PS amounts and EEG rhythmic activities in transgenic Pmch-cre mice...
March 29, 2018: Sleep
https://www.readbyqxmd.com/read/29615295/radiologic-and-pathologic-response-to-neoadjuvant-chemotherapy-predicts-survival-in-patients-undergoing-the-liver-first-approach-for-synchronous-colorectal-liver-metastases
#3
Giammauro Berardi, Marc De Man, Stéphanie Laurent, Peter Smeets, Federico Tomassini, Riccardo Ariotti, Anne Hoorens, Jo van Dorpe, Oswald Varin, Karen Geboes, Roberto I Troisi
PURPOSE: To investigate the short- and long-term outcomes of liver first approach (LFA) in patients with synchronous colorectal liver metastases (CRLM), evaluating the predictive factors of survival. METHODS: Sixty-two out of 301 patients presenting with synchronous CRLM underwent LFA between 2007 and 2016. All patients underwent neoadjuvant chemotherapy. After neoadjuvant treatment patients were re-evaluated according to the Response Evaluation Criteria in Solid Tumors (RECIST)...
March 21, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29609317/measuring-the-kerr-nonlinearity-via-seeded-kerr-instability-amplification-conceptual-analysis
#4
M Nesrallah, A Hakami, G Bart, C R McDonald, C Varin, T Brabec
Whereas the Kerr nonlinearity is well understood in the perturbative limit of nonlinear optics, there is considerable discussion about its functional form and magnitude at extreme intensities, at which point matter starts to ionize. Here, we introduce a concept to answer this question and theoretically analyze its feasibility. We demonstrate that seeded Kerr instability amplification provides clear signatures from which functional form and magnitude of the Kerr nonlinearity can be extracted in the non-perturbative limit of nonlinear optics...
March 19, 2018: Optics Express
https://www.readbyqxmd.com/read/29525196/pharmacokinetics-and-pharmacodynamics-of-nebulized-and-intratracheal-milrinone-in-a-swine-model-of-hypercapnia-pulmonary-hypertension
#5
Paul Gavra, André Y Denault, Yves Théoret, Louis P Perrault, France Varin
OBJECTIVES: Milrinone pulmonary administration is used currently for the treatment of pulmonary hypertension. Several methods are available: simple jet nebulization, vibrating mesh nebulization, intratracheal instillation, and intratracheal atomization. The aim of this study was to explore the concentration-effect relationship of milrinone for each of these methods. DESIGN: Observational open-label pharmacokinetic/pharmacodynamics cohort study. SETTING: Single-center, hospital animal laboratory...
January 31, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29440469/air-drop-blood-supply-in-the-french-army
#6
Olivier Javaudin, A Baillon, N Varin, C Martinaud, T Pouget, C Civadier, B Clavier, A Sailliol
BACKGROUND: Haemorrhagic shock remains the leading cause of preventable death in overseas and austere settings. Transfusion of blood components is critical in the management of this kind of injury. For French naval and ground military units, this supply often takes too long considering the short shelf-life of red blood cell concentrates (RBCs) and the limited duration of transport in cooling containers (five to six days). Air-drop supply could be an alternative to overcome these difficulties on the condition that air-drop does not cause damage to blood units...
February 12, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29436616/synergistic-promoting-effects-of-pentoxifylline-and-simvastatin-on-the-apoptosis-of-triple-negative-mda-mb-231-breast-cancer-cells
#7
Yessica Cristina Castellanos-Esparza, Shuang Wu, Limin Huang, Catherine Buquet, Rong Shen, Berenice Sanchez-Gonzalez, Ethel Awilda García Latorre, Olivier Boyer, Remi Varin, Luis Antonio Jiménez-Zamudio, Anne Janin, Jean-Pierre Vannier, Hong Li, He Lu
Pentoxifylline (PTX), a xanthine family molecule and simvastatin (SIM), an anti-hypercholesterolemic agent, have recently been considered as sensitizers to chemotherapy and radiotherapy. The present in vitro study evaluated their antitumor synergistic effects on MDA‑MB‑231 breast cancer cells characterized by the triple‑negative phenotype (TNP). The anti-proliferative effects of these two agents were evaluated by MTT and clonogenic assays. Cell cycle progression was examined using propidium iodide staining...
April 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29417923/a-bundle-of-measures-to-control-an-outbreak-of-pseudomonas-aeruginosa-associated-with-p-trap-contamination
#8
Houssein Gbaguidi-Haore, Amélie Varin, Pascal Cholley, Michelle Thouverez, Didier Hocquet, Xavier Bertrand
OBJECTIVE To describe an outbreak of multidrug-resistant Pseudomonas aeruginosa in which the hospital waste-pipe system was the likely source of contamination and to report the bundle of measures that facilitated the long-term control of the outbreak. DESIGN Outbreak investigation. SETTING The hematology unit of a tertiary-care referral center. PATIENTS Patients who were colonized or infected with P. aeruginosa belonging to the clonal outbreak. METHODS Patients admitted to our 15-bed stem-cell transplantation hematology unit were screened for P...
February 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29353680/feedback-mechanisms-between-snow-and-atmospheric-mercury-results-and-observations-from-field-campaigns-on-the-antarctic-plateau
#9
Andrea Spolaor, Hélène Angot, Marco Roman, Aurélien Dommergue, Claudio Scarchilli, Massimiliano Vardè, Massimo Del Guasta, Xanthi Pedeli, Cristiano Varin, Francesca Sprovieri, Olivier Magand, Michel Legrand, Carlo Barbante, Warren R L Cairns
The Antarctic Plateau snowpack is an important environment for the mercury geochemical cycle. We have extensively characterized and compared the changes in surface snow and atmospheric mercury concentrations that occur at Dome C. Three summer sampling campaigns were conducted between 2013 and 2016. The three campaigns had different meteorological conditions that significantly affected mercury deposition processes and its abundance in surface snow. In the absence of snow deposition events, the surface mercury concentration remained stable with narrow oscillations, while an increase in precipitation results in a higher mercury variability...
April 2018: Chemosphere
https://www.readbyqxmd.com/read/29331188/-care-pathway-and-life-course-of-drug-addicted-patients
#10
REVIEW
Franck Warembourg, Victoria Varin
Placing drug addicts, notably heroin addicts, at the centre of their care project, itself part of a life project, is the objective of the Le Lac d'Argent association in Annecy. Caregivers have been able to reflect on their practices and help to fight against preconceived ideas. This article presents the experience of a global support approach.
January 2018: Revue de L'infirmière
https://www.readbyqxmd.com/read/29310711/impact-of-collaborative-pharmaceutical-care-on-in-patients-medication-safety-study-protocol-for-a-stepped-wedge-cluster-randomized-trial-medrev-study
#11
Géraldine Leguelinel-Blache, Christel Castelli, Clarisse Roux-Marson, Sophie Bouvet, Sandrine Andrieu, Philippe Cestac, Rémy Collomp, Paul Landais, Bertrice Loulière, Christelle Mouchoux, Rémi Varin, Benoit Allenet, Pierrick Bedouch, Jean-Marie Kinowski
BACKGROUND: Clinical pharmaceutical care has long played an important role in the improvement of healthcare safety. Pharmaceutical care is a collaborative care approach, implicating all the actors of the medication circuit in order to prevent and correct drug-related problems that can lead to adverse drug events. The collaborative pharmaceutical care performed during patients' hospitalization requires two mutually reinforcing activities: medication reconciliation and medication review...
January 8, 2018: Trials
https://www.readbyqxmd.com/read/29258384/long-term-survival-after-multimodality-therapy-including-surgery-for-metastatic-esophageal-cancer
#12
Elke Van Daele, Vincenzo Scuderi, Eva Pape, Dirk Van de Putte, Oswald Varin, Yves Van Nieuwenhove, Wim Ceelen, Roberto Troisi, Piet Pattyn
BACKGROUND AND OBJECTIVES: Esophageal cancer (EC) remains an aggressive disease with a poor survival. Management of metastatic EC is limited to palliative chemotherapy (CT). Scientific contributions regarding the role of surgery are scarce and controversial. We analysed outcome of surgically treated metastatic EC patients. METHODS: We retrospectively identified surgically treated metastatic EC patients from our esophagectomy database. The aim of this study was to evaluate surgical complications, pathological response, oncological outcome and mean survival of these aggressively treated stage IV cancer patients...
December 19, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29107524/a-polyphenol-rich-cranberry-extract-reverses-insulin-resistance-and-hepatic-steatosis-independently-of-body-weight-loss
#13
Fernando F Anhê, Renato T Nachbar, Thibault V Varin, Vanessa Vilela, Stéphanie Dudonné, Geneviève Pilon, Maryse Fournier, Marc-André Lecours, Yves Desjardins, Denis Roy, Emile Levy, André Marette
OBJECTIVE: Previous studies have reported that polyphenol-rich extracts from various sources can prevent obesity and associated gastro-hepatic and metabolic disorders in diet-induced obese (DIO) mice. However, whether such extracts can reverse obesity-linked metabolic alterations remains unknown. In the present study, we aimed to investigate the potential of a polyphenol-rich extract from cranberry (CE) to reverse obesity and associated metabolic disorders in DIO-mice. METHODS: Mice were pre-fed either a Chow or a High Fat-High Sucrose (HFHS) diet for 13 weeks to induce obesity and then treated either with CE (200 mg/kg, Chow + CE, HFHS + CE) or vehicle (Chow, HFHS) for 8 additional weeks...
December 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29060435/symptom-based-data-preprocessing-for-the-detection-of-disease-outbreak
#14
Khanita Duangchaemkarn, Varin Chaovatut, Phongtape Wiwatanadate, Ekkarat Boonchieng
Early warning systems for outbreak detection is a challenge topic for researchers in the epidemiology and biomedical informatics fields. We are proposing a new method for detecting disease epidemics using a symptom-based approach. The data was collected from developed mobile applications which include users' demographic information and a list of chief complaint symptoms. Deliberated outbreaks are differentiated from seasonal outbreak by specific symptoms that represent a sign of infection. These symptoms were grouped, classified, and then converted to a time-series digital signal using the consensus scoring approach...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29055045/diagnostic-relevance-of-ige-sensitization-profiles-to-eight-recombinant-phleum-pratense-molecules
#15
Francesca Cipriani, Carla Mastrorilli, Salvatore Tripodi, Giampaolo Ricci, Serena Perna, Valentina Panetta, Riccardo Asero, Arianna Dondi, Annamaria Bianchi, Nunzia Maiello, Michele Miraglia Del Giudice, Tullio Frediani, Francesco Macrì, Sandra Lucarelli, Iride Dello Iacono, Maria Francesca Patria, Elena Varin, Diego Peroni, Loredana Chini, Viviana Moschese, Roberto Bernardini, Giuseppe Pingitore, Umberto Pelosi, Mariangela Tosca, Francesco Paravati, Ifigenia Sfika, Andrea Di Rienzo Businco, Calotta Povesi Dascola, Pasquale Comberiati, Simone Frediani, Caterina Lambiase, Maria Carmen Verga, Diego Faggian, Mario Plebani, Mauro Calvani, Carlo Caffarelli, Paolo Maria Matricardi
BACKGROUND: Grass pollen-related seasonal allergic rhinoconjunctivitis (SARg) is clinically heterogeneous in severity, comorbidities and response to treatment. The component-resolved diagnostics disclosed also a high heterogeneity at molecular level. Our study aimed at analyzing the characteristics of the IgE sensitization to Phleum pratense molecules and investigating the diagnostic relevance of such molecules in childhood. METHODS: We examined 1120 children (age 4-18y) with SARg...
October 20, 2017: Allergy
https://www.readbyqxmd.com/read/28873292/dose-exposure-simulation-for-piperacillin-tazobactam-dosing-strategies-in-infants-and-young-children
#16
Céline Thibault, Nastya Kassir, Yves Théorêt, France Varin, Catherine Litalien, Julie Autmizguine
BACKGROUND: Extended piperacillin-tazobactam (TZP) infusions have been associated with favourable outcomes. There are currently no pediatric dosing recommendations. OBJECTIVES: To determine appropriate TZP dosing strategies in children 2 months - 6 years according to age and different minimal inhibitory concentrations (MICs). METHODS: Age and weight were simulated for 1000 children. Post-hoc pharmacokinetic parameter estimates were generated using published clearance and volume of distribution data...
August 21, 2017: Journal of Population Therapeutics and Clinical Pharmacology
https://www.readbyqxmd.com/read/28836228/catherine-larr%C3%A3-re-rapha%C3%A3-l-larr%C3%A3-re-penser-et-agir-avec-la-nature-une-enqu%C3%A3%C2%AAte-philosophique-%C3%A3-ditions-la-d%C3%A3-couverte-coll-sciences-humaines-france-2015-374-pp-%C3%A2-14-99
#17
Héloïse Varin
No abstract text is available yet for this article.
September 2017: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/28791387/atelocollagen-mediated-in-vivo-sirna-transfection-in-ovarian-carcinoma-is-influenced-by-tumor-site-sirna-target-and-administration-route
#18
Matthieu Meryet-Figuière, Charlotte Lecerf, Emilie Varin, Jean-Luc Coll, Marie-Hélène Louis, Soizic Dutoit, Florence Giffard, Cécile Blanc-Fournier, Siham Hedir, Nicolas Vigneron, Emilie Brotin, Laurent Pelletier, Véronique Josserand, Christophe Denoyelle, Laurent Poulain
Ovarian cancer is the leading cause of death from gynecological malignancies worldwide, and innate or acquired chemoresistance of ovarian cancer cells is the major cause of therapeutic failure. It has been demonstrated that the concomitant inhibition of Bcl-xL and Mcl-1 anti-apoptotic activities is able to trigger apoptosis in chemoresistant ovarian cancer cells. In this context, siRNA-mediated Bcl‑xL and Mcl-1 inhibition constitutes an appealing strategy by which to eliminate chemoresistant cancer cells...
October 2017: Oncology Reports
https://www.readbyqxmd.com/read/28782710/use-of-nebulized-milrinone-in-cardiac-surgery-comparison-of-vibrating-mesh-and-simple-jet-nebulizers
#19
Paul Gavra, Maxime Laflamme, André Y Denault, Yves Théoret, Louis P Perrault, France Varin
Cardiopulmonary bypass triggers an ischemia-reperfusion injury with endothelial dysfunction in the pulmonary circulation which can result in pulmonary hypertension. Inhaled milrinone reduces this reperfusion phenomenon and two methods commonly available for administering it are simple jet and vibrating mesh nebulizations. However, neither their generated milrinone particle size profiles, nor their ability to aid endothelial relaxation have been compared. Simple jet and vibrating mesh particle size distributions of milrinone were verified through cascade impaction and their efficacy was tested on a cardiopulmonary bypass (CPB) swine model...
October 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28753152/comment-on-a-novel-method-of-human-adipose-derived-stem-cell-isolation-with-resultant-increased-cell-yield
#20
Jérôme Laloze, Nicolas Bertheuil, Julie Usseglio-Grosso, Audrey Varin, Benoit Chaput
No abstract text is available yet for this article.
July 15, 2017: Plastic and Reconstructive Surgery
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