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https://www.readbyqxmd.com/read/28224110/comparison-of-inhaled-milrinone-nitric-oxide-and-prostacyclin-in-acute-respiratory-distress-syndrome
#1
Martin Albert, Daniel Corsilli, David R Williamson, Marc Brosseau, Patrick Bellemare, Stéphane Delisle, Anne Qn Nguyen, France Varin
AIM: To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome (ARDS). METHODS: Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of iNO (20 ppm) or nebulized epoprostenol (10 μg/mL) was done in all patients...
February 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28219656/ultrasound-abnormalities-in-septic-arthritis-are-associated-with-functional-outcomes
#2
Emeline Gaigneux, Grégoire Cormier, Stéphane Varin, Oriane Mérot, Yves Maugars, Benoit Le Goff
OBJECTIVES: To describe the ultrasound abnormalities seen in septic arthritis and to assess their associations with clinical, biological, and radiological outcomes. METHODS: We prospectively included 34 patients with septic arthritis of a native joint (knee, n=19; shoulder, n=6; hip, n=4; ankle, n=3; or wrist, n=2). Ultrasonography was performed to record synovial-membrane thickness and vascularity, joint effusion, and abnormalities of adjacent soft tissues, at baseline then 4days, 2weeks, and 3months later...
February 17, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28099184/efficacy-of-vitamin-b6-in-lithium-associated-tremor-a-case-series
#3
Manuel Dias Alves, Laure Varin, Laura M Fiori, Bruno Etain, Jean-Michel Azorin, Raoul Belzeaux
No abstract text is available yet for this article.
January 18, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28068408/pharmacokinetics-of-lidocaine-hydrochloride-administered-with-or-without-adrenaline-for-the-paravertebral-brachial-plexus-block-in-dogs
#4
Amélie Choquette, Eric Troncy, Martin Guillot, France Varin, Jérôme R E Del Castillo
Adrenaline is known to prolong the duration of local anesthesia but its effects on the pharmacokinetic processes of local anesthetic drugs are not fully understood. Our objective was to develop a compartmental model for quantification of adrenaline's impact on the pharmacokinetics of perineurally-injected lidocaine in the dog. Dogs were subjected to paravertebral brachial plexus block using lidocaine alone or adrenalinated lidocaine. Data was collected through a prospective, randomised, blinded crossover protocol performed over three periods...
2017: PloS One
https://www.readbyqxmd.com/read/28054556/phosphorylation-impact-on-spleen-tyrosine-kinase-conformation-by-surface-enhanced-raman-spectroscopy
#5
Maximilien Cottat, Ryohei Yasukuni, Yo Homma, Nathalie Lidgi-Guigui, Nadine Varin-Blank, Marc Lamy de la Chapelle, Christine Le Roy
Spleen Tyrosine Kinase (Syk) plays a crucial role in immune cell signalling and its altered expression or activation are involved in several cancers. Syk activity relies on its phosphorylation status and its multiple phosphorylation sites predict several Syk conformations. In this report, we characterized Syk structural changes according to its phosphorylation/activation status by Surface Enhanced Raman Spectroscopy (SERS). Unphosphorylated/inactive and phosphorylated/active Syk forms were produced into two expression systems with different phosphorylation capability...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28002249/phenotypic-analysis-of-stromal-vascular-fraction-after-mechanical-shear-reveals-stress-induced-progenitor-populations
#6
Benoit Chaput, Jerome Laloze, Jean-Louis Grolleau, Nicolas Espagnolle, Nicolas Bertheuil, Audrey Varin
No abstract text is available yet for this article.
December 19, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27992693/scleroderma-peripheral-b-lymphocytes-secrete-interleukin-6-and-tgf-%C3%AE-and-activate-fibroblasts
#7
Nicolas Dumoitier, Benjamin Chaigne, Alexis Régent, Sébastien Lofek, Maïssa Mhibik, Peter Dorfmüller, Benjamin Terrier, Jonathan London, Alice Bérezné, Nicolas Tamas, Nadine Varin-Blank, Luc Mouthon
OBJECTIVE: To study the role of B lymphocytes in systemic sclerosis (SSc). PATIENTS AND METHODS: Peripheral B cell subpopulations, interleukin 6 (IL-6) and transforming growth factor-beta (TGF-β) productions were analyzed using flow cytometry and multiplex assay. Fibroblasts proliferation rate upon incubation with supernatants of B cells isolated from SSc patients or healthy controls (HC) was assessed using XTT, BrdU and Ki67. Collagen production was assessed using a collagen assay...
December 19, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27863673/laser-irradiation-to-produce-amorphous-pharmaceuticals
#8
Varin Titapiwatanakun, Junlathip Tankul, Abdul W Basit, Simon Gaisford
Using a high-power CO2 laser to irradiate powder beds, it was possible to induce phase transformation to the amorphous state. Irradiation of a model drug, indometacin, resulted in formation of a glass. Varying the settings of the laser (power and raster speed) was shown to change the physicochemical properties of the glasses produced and all irradiated glasses were found to be more stable than a reference glass produced by melt-quenching. Irradiation of a powder blend of paracetamol and polyvinylpyrrolidone K30 was found to produce a solid amorphous dispersion...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27825575/decreased-patient-exposure-to-ionizing-radiation-during-interventional-rheumatology-procedures-after-optimization-of-protection
#9
Céline Cozic, Fabien Audran, Christophe Blanchard, Christophe David, Vincent Andre, Michel Caulier, Stéphane Varin, Gilles Tanguy, Jérôme Dimet, Grégoire Cormier
OBJECTIVES: To decrease radiation exposure of patients undergoing interventional rheumatology procedures, without adversely affecting quality of care. METHODS: The radiation dose received, assessed by the dose-area product (DAP), was measured during 283 intraarticular injections performed under fluoroscopic guidance between May and July 2013. Then, three steps were taken to decrease patients' radiation exposure: a copper filter was added, the anti-scatter grid was removed, and exposure cell sensitivity was set at the highest value...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27755299/reply-mechanical-isolation-of-stromal-vascular-fraction-a-new-advance-in-stem-cell-therapy
#10
Benoit Chaput, Nicolas Bertheuil, Jean-Louis Grolleau, Ignacio Garrido, Jerome Laloze, Audrey Varin
No abstract text is available yet for this article.
February 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27755297/concomitant-liposuction-reduces-complications-of-vertical-medial-thigh-lift-in-massive-weight-loss-patients
#11
Nicolas Bertheuil, Antoine de Runz, Audrey Varin, Raphael Carloni, Caroline Francois, Benoit Chaput
No abstract text is available yet for this article.
February 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27733868/insights-in-hypothesis-testing-and-making-decisions-in-biomedical-research
#12
Varin Sacha, Demosthenes B Panagiotakos
It is a fact that p values are commonly used for inference in biomedical and other social fields of research. Unfortunately, the role of p value is very often misused and misinterpreted; that is why it has been recommended the use of resampling methods, like the bootstrap method, to calculate the confidence interval, which provides more robust results for inference than does p value. In this review a discussion is made about the use of p values through hypothesis testing and its alternatives using resampling methods to develop confidence intervals of the tested statistic or effect measure...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27630205/apple-peel-polyphenols-a-key-player-in-the-prevention-and-treatment-of-experimental-inflammatory-bowel-disease
#13
Marie-Claude Denis, Denis Roy, Pantea Rahmani Yeganeh, Yves Desjardins, Thibault Varin, Nour Haddad, Devendra Amre, Alain Théophile Sané, Carole Garofalo, Alexandra Furtos, Natalie Patey, Edgard Delvin, Eric Tremblay, André Marette, Jean-François Beaulieu, Emile Levy
Diets rich in fruits and vegetables may reduce oxidative stress (OxS) and inflammation via several mechanisms. These beneficial effects may be due to their high polyphenol content. The aims of the present study are to evaluate the preventive and therapeutic aspects of polyphenols in dried apple peel powder (DAPP) on intestinal inflammation while elucidating the underlying mechanisms and clinical benefits. Induction of intestinal inflammation in mice was performed by oral administration of the inflammatory agent dextran sulfate sodium (DSS) at 2...
December 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27470232/a-multicentre-randomized-controlled-trial-of-inhaled-milrinone-in-high-risk-cardiac-surgical-patients
#14
André Y Denault, Jean S Bussières, Ramiro Arellano, Barry Finegan, Paul Gavra, François Haddad, Anne Q N Nguyen, France Varin, Annik Fortier, Sylvie Levesque, Yanfen Shi, Mahsa Elmi-Sarabi, Jean-Claude Tardif, Louis P Perrault, Jean Lambert
PURPOSE: Inhaled milrinone (iMil) has been used for the treatment of pulmonary hypertension (PH) but its efficacy, safety, and prophylactic effects in facilitating separation from cardiopulmonary bypass (CPB) and preventing right ventricular (RV) dysfunction have not yet been evaluated in a clinical trial. The purpose of this study was to investigate if iMil administered before CPB would be superior to placebo in facilitating separation from CPB. METHODS: High-risk cardiac surgical patients with PH were randomized to receive iMil or placebo after the induction of anesthesia and before CPB...
October 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/27464833/cellular-response-to-alkylating-agent-mnng-is-impaired-in-stat1-deficients-cells
#15
Laurent Ah-Koon, Denis Lesage, Elodie Lemadre, Inès Souissi, Remi Fagard, Nadine Varin-Blank, Emmanuelle E Fabre, Olivier Schischmanoff
The SN 1 alkylating agents activate the mismatch repair system leading to delayed G2 /M cell cycle arrest and DNA repair with subsequent survival or cell death. STAT1, an anti-proliferative and pro-apoptotic transcription factor is known to potentiate p53 and to affect DNA-damage cellular response. We studied whether STAT1 may modulate cell fate following activation of the mismatch repair system upon exposure to the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Using STAT1-proficient or -deficient cell lines, we found that STAT1 is required for: (i) reduction in the extent of DNA lesions, (ii) rapid phosphorylation of T68-CHK2 and of S15-p53, (iii) progression through the G2 /M checkpoint and (iv) long-term survival following treatment with MNNG...
October 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27443888/potentiation-of-the-bioavailability-of-blueberry-phenolic-compounds-by-co-ingested-grape-phenolic-compounds-in-mice-revealed-by-targeted-metabolomic-profiling-in-plasma-and-feces
#16
Stéphanie Dudonné, Alexandre Dal-Pan, Pascal Dubé, Thibault V Varin, Frédéric Calon, Yves Desjardins
The low bioavailability of dietary phenolic compounds, resulting from poor absorption and high rates of metabolism and excretion, is a concern as it can limit their potential beneficial effects on health. Targeted metabolomic profiling in plasma and feces of mice supplemented for 15 days with a blueberry extract, a grape extract or their combination revealed significantly increased plasma concentrations (3-5 fold) of blueberry phenolic metabolites in the presence of a co-ingested grape extract, associated with an equivalent decrease in their appearance in feces...
August 10, 2016: Food & Function
https://www.readbyqxmd.com/read/27437928/amino-acid-based-formula-in-cow-s-milk-allergy-long-term-effects-on-body-growth-and-protein-metabolism-a-randomized-trial
#17
Roberto Berni Canani, Rita Nocerino, Tullio Frediani, Sandra Lucarelli, Carmen Di Scala, Elena Varin, Ludovica Leone, Antonella Muraro, Carlo Agostoni
OBJECTIVES: The long-term effects of amino acid-based formula (AAF) in the treatment of cow's milk allergy (CMA) is largely unexplored. This study comparatively evaluates body growth and protein metabolism in CMA children treated with AAF or with extensively hydrolysed whey formula (eHWF), and healthy controls (HCs). METHODS: A 12-month multicentre randomised control trial (RCT) was conducted in outpatients with CMA (aged 5-12 m) randomised in two groups, treated with AAF (Group 1) and eHWF (Group 2), and compared with HCs (Group 3) fed with follow-on (if age <12 m) or growing-up formula (if age >12 m)...
July 20, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27425035/cyp4f2-affects-phenotypic-outcome-in-adrenoleukodystrophy-by-modulating-the-clearance-of-very-long-chain-fatty-acids
#18
Catherine E van Engen, Rob Ofman, Inge M E Dijkstra, Tessa Jacobs van Goethem, Eveline Verheij, Jennifer Varin, Michel Vidaud, Ronald J A Wanders, Patrick Aubourg, Stephan Kemp, Mathieu Barbier
X-linked adrenoleukodystrophy (ALD) is a severe neurodegenerative disorder caused by the accumulation of very long-chain fatty acids (VLCFA) due to mutations in the ABCD1 gene. The phenotypic spectrum ranges from a fatal cerebral demyelinating disease in childhood (cerebral ALD) to a progressive myelopathy without cerebral involvement in adulthood (adrenomyeloneuropathy). Because ABCD1 mutations have no predictive value with respect to clinical outcome a role for modifier genes was postulated. We report that the CYP4F2 polymorphism rs2108622 increases the risk of developing cerebral ALD in Caucasian patients...
October 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27357206/report-of-the-european-society-of-cardiology-cardiovascular-round-table-regulatory-workshop-update-of-the-evaluation-of-new-agents-for-the-treatment-of-acute-coronary-syndrome-executive-summary
#19
Héctor Bueno, Pieter de Graeff, Isabelle Richard-Lordereau, Joseph Emmerich, Keith Aa Fox, Carola P Friedman, Christophe Gaudin, Amany El-Gazayerly, Samantha Goldman, Melanie Hemmrich, Robert A Henderson, Anders Himmelmann, Alar Irs, Neville Jackson, Stefan K James, Hugo A Katus, Andrea Laslop, Ian Laws, Roxana Mehran, Seleen Ong, Krishna Prasad, Marco Roffi, Giuseppe Mc Rosano, Martin Rose, Peter R Sinnaeve, Wendy Gattis Stough, Kristian Thygesen, Frans Van de Werf, Claire Varin, Freek Wa Verheugt, Maria de Los Angeles Alonso García
Regulatory authorities interpret the results of randomized controlled trials according to published principles. The European Medicines Agency (EMA) is planning a revision of the 2000 and 2003 guidance documents on clinical investigation of new medicinal products for the treatment of acute coronary syndrome (ACS) to achieve consistency with current knowledge in the field. This manuscript summarizes the key output from a collaborative workshop, organized by the Cardiovascular Round Table and the European Affairs Committee of the European Society of Cardiology, involving clinicians, academic researchers, trialists, European and US regulators, and pharmaceutical industry researchers...
June 29, 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/27307342/mechanically-isolated-stromal-vascular-fraction-provides-a-valid-and-useful-collagenase-free-alternative-technique-a-comparative-study
#20
Benoit Chaput, Nicolas Bertheuil, Marina Escubes, Jean-Louis Grolleau, Ignacio Garrido, Jérôme Laloze, Nicolas Espagnolle, Louis Casteilla, Luc Sensebé, Audrey Varin
BACKGROUND: The use of stromal vascular fraction and adipose-derived stromal cells in tissue regeneration is now being increasingly investigated, and studies have demonstrated that adipose-derived stromal cells present differentiation and immunomodulatory capacities. The development of a rapid, inexpensive, and enzyme-free technique to isolate adipose-derived stromal cell-enriched stromal vascular fraction is a major goal for stem cell therapy. Therefore, the authors compared innovative mechanical procedures to the gold standard technique, collagenase digestion...
October 2016: Plastic and Reconstructive Surgery
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