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https://www.readbyqxmd.com/read/27863673/laser-irradiation-to-produce-amorphous-pharmaceuticals
#1
Varin Titapiwatanakun, Junlathip Tankul, Abdul W Basit, Simon Gaisford
Using a high-power CO2 laser to irradiate powder beds, it was possible to induce phase transformation to the amorphous state. Irradiation of a model drug, indometacin, resulted in formation of a glass. Varying the settings of the laser (power and raster speed) was shown to change the physicochemical properties of the glasses produced and all irradiated glasses were found to be more stable than a reference glass produced by melt-quenching. Irradiation of a powder blend of paracetamol and polyvinylpyrrolidone K30 was found to produce a solid amorphous dispersion...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27825575/decreased-patient-exposure-to-ionizing-radiation-during-interventional-rheumatology-procedures-after-optimization-of-protection
#2
Céline Cozic, Fabien Audran, Christophe Blanchard, Christophe David, Vincent Andre, Michel Caulier, Stéphane Varin, Gilles Tanguy, Jérôme Dimet, Grégoire Cormier
OBJECTIVES: To decrease radiation exposure of patients undergoing interventional rheumatology procedures, without adversely affecting quality of care. METHODS: The radiation dose received, assessed by the dose-area product (DAP), was measured during 283 intraarticular injections performed under fluoroscopic guidance between May and July 2013. Then, three steps were taken to decrease patients' radiation exposure: a copper filter was added, the anti-scatter grid was removed, and exposure cell sensitivity was set at the highest value...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27755299/-mechanical-isolation-of-stromal-vascular-fraction-a-new-advance-in-stem-cells-therapy
#3
Benoit Chaput, Nicolas Bertheuil, Jean-Louis Grolleau, Ignacio Garrido, Jerome Laloze, Audrey Varin
No abstract text is available yet for this article.
October 10, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27755297/extensive-concomitant-liposuction-reduces-complications-in-patient-following-massive-weight-loss
#4
Nicolas Bertheuil, Antoine De Runz, Audrey Varin, Raphael Carloni, Caroline Francois, Benoit Chaput
No abstract text is available yet for this article.
October 10, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27733868/insights-in-hypothesis-testing-and-making-decisions-in-biomedical-research
#5
Varin Sacha, Demosthenes B Panagiotakos
It is a fact that p values are commonly used for inference in biomedical and other social fields of research. Unfortunately, the role of p value is very often misused and misinterpreted; that is why it has been recommended the use of resampling methods, like the bootstrap method, to calculate the confidence interval, which provides more robust results for inference than does p value. In this review a discussion is made about the use of p values through hypothesis testing and its alternatives using resampling methods to develop confidence intervals of the tested statistic or effect measure...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27630205/apple-peel-polyphenols-a-key-player-in-the-prevention-and-treatment-of-experimental-inflammatory-bowel-disease
#6
Marie-Claude Denis, Denis Roy, Pantea Rahmani Yeganeh, Yves Desjardins, Thibault Varin, Nour Haddad, Devendra Amre, Alain Théophile Sané, Carole Garofalo, Alexandra Furtos, Natalie Patey, Edgard Delvin, Eric Tremblay, André Marette, Jean-François Beaulieu, Emile Levy
Diets rich in fruits and vegetables may reduce oxidative stress (OxS) and inflammation via several mechanisms. These beneficial effects may be due to their high polyphenol content. The aims of the present study are to evaluate the preventive and therapeutic aspects of polyphenols in dried apple peel powder (DAPP) on intestinal inflammation while elucidating the underlying mechanisms and clinical benefits. Induction of intestinal inflammation in mice was performed by oral administration of the inflammatory agent dextran sulfate sodium (DSS) at 2...
December 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27470232/a-multicentre-randomized-controlled-trial-of-inhaled-milrinone-in-high-risk-cardiac-surgical-patients
#7
André Y Denault, Jean S Bussières, Ramiro Arellano, Barry Finegan, Paul Gavra, François Haddad, Anne Q N Nguyen, France Varin, Annik Fortier, Sylvie Levesque, Yanfen Shi, Mahsa Elmi-Sarabi, Jean-Claude Tardif, Louis P Perrault, Jean Lambert
PURPOSE: Inhaled milrinone (iMil) has been used for the treatment of pulmonary hypertension (PH) but its efficacy, safety, and prophylactic effects in facilitating separation from cardiopulmonary bypass (CPB) and preventing right ventricular (RV) dysfunction have not yet been evaluated in a clinical trial. The purpose of this study was to investigate if iMil administered before CPB would be superior to placebo in facilitating separation from CPB. METHODS: High-risk cardiac surgical patients with PH were randomized to receive iMil or placebo after the induction of anesthesia and before CPB...
October 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/27464833/cellular-response-to-alkylating-agent-mnng-is-impaired-in-stat1-deficients-cells
#8
Laurent Ah-Koon, Denis Lesage, Elodie Lemadre, Inès Souissi, Remi Fagard, Nadine Varin-Blank, Emmanuelle E Fabre, Olivier Schischmanoff
The SN 1 alkylating agents activate the mismatch repair system leading to delayed G2 /M cell cycle arrest and DNA repair with subsequent survival or cell death. STAT1, an anti-proliferative and pro-apoptotic transcription factor is known to potentiate p53 and to affect DNA-damage cellular response. We studied whether STAT1 may modulate cell fate following activation of the mismatch repair system upon exposure to the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Using STAT1-proficient or -deficient cell lines, we found that STAT1 is required for: (i) reduction in the extent of DNA lesions, (ii) rapid phosphorylation of T68-CHK2 and of S15-p53, (iii) progression through the G2 /M checkpoint and (iv) long-term survival following treatment with MNNG...
October 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27443888/potentiation-of-the-bioavailability-of-blueberry-phenolic-compounds-by-co-ingested-grape-phenolic-compounds-in-mice-revealed-by-targeted-metabolomic-profiling-in-plasma-and-feces
#9
Stéphanie Dudonné, Alexandre Dal-Pan, Pascal Dubé, Thibault V Varin, Frédéric Calon, Yves Desjardins
The low bioavailability of dietary phenolic compounds, resulting from poor absorption and high rates of metabolism and excretion, is a concern as it can limit their potential beneficial effects on health. Targeted metabolomic profiling in plasma and feces of mice supplemented for 15 days with a blueberry extract, a grape extract or their combination revealed significantly increased plasma concentrations (3-5 fold) of blueberry phenolic metabolites in the presence of a co-ingested grape extract, associated with an equivalent decrease in their appearance in feces...
August 10, 2016: Food & Function
https://www.readbyqxmd.com/read/27437928/amino-acid-based-formula-in-cow-s-milk-allergy-long-term-effects-on-body-growth-and-protein-metabolism-a-randomized-trial
#10
Roberto Berni Canani, Rita Nocerino, Tullio Frediani, Sandra Lucarelli, Carmen Di Scala, Elena Varin, Ludovica Leone, Antonella Muraro, Carlo Agostoni
OBJECTIVES: The long-term effects of amino acid-based formula (AAF) in the treatment of cow's milk allergy (CMA) is largely unexplored. This study comparatively evaluates body growth and protein metabolism in CMA children treated with AAF or with extensively hydrolysed whey formula (eHWF), and healthy controls (HCs). METHODS: A 12-month multicentre randomised control trial (RCT) was conducted in outpatients with CMA (aged 5-12 m) randomised in two groups, treated with AAF (Group 1) and eHWF (Group 2), and compared with HCs (Group 3) fed with follow-on (if age <12 m) or growing-up formula (if age >12 m)...
July 20, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27425035/cyp4f2-affects-phenotypic-outcome-in-adrenoleukodystrophy-by-modulating-the-clearance-of-very-long-chain-fatty-acids
#11
Catherine E van Engen, Rob Ofman, Inge M E Dijkstra, Tessa Jacobs van Goethem, Eveline Verheij, Jennifer Varin, Michel Vidaud, Ronald J A Wanders, Patrick Aubourg, Stephan Kemp, Mathieu Barbier
X-linked adrenoleukodystrophy (ALD) is a severe neurodegenerative disorder caused by the accumulation of very long-chain fatty acids (VLCFA) due to mutations in the ABCD1 gene. The phenotypic spectrum ranges from a fatal cerebral demyelinating disease in childhood (cerebral ALD) to a progressive myelopathy without cerebral involvement in adulthood (adrenomyeloneuropathy). Because ABCD1 mutations have no predictive value with respect to clinical outcome a role for modifier genes was postulated. We report that the CYP4F2 polymorphism rs2108622 increases the risk of developing cerebral ALD in Caucasian patients...
October 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27357206/report-of-the-european-society-of-cardiology-cardiovascular-round-table-regulatory-workshop-update-of-the-evaluation-of-new-agents-for-the-treatment-of-acute-coronary-syndrome-executive-summary
#12
Héctor Bueno, Pieter de Graeff, Isabelle Richard-Lordereau, Joseph Emmerich, Keith Aa Fox, Carola P Friedman, Christophe Gaudin, Amany El-Gazayerly, Samantha Goldman, Melanie Hemmrich, Robert A Henderson, Anders Himmelmann, Alar Irs, Neville Jackson, Stefan K James, Hugo A Katus, Andrea Laslop, Ian Laws, Roxana Mehran, Seleen Ong, Krishna Prasad, Marco Roffi, Giuseppe Mc Rosano, Martin Rose, Peter R Sinnaeve, Wendy Gattis Stough, Kristian Thygesen, Frans Van de Werf, Claire Varin, Freek Wa Verheugt, Maria de Los Angeles Alonso García
Regulatory authorities interpret the results of randomized controlled trials according to published principles. The European Medicines Agency (EMA) is planning a revision of the 2000 and 2003 guidance documents on clinical investigation of new medicinal products for the treatment of acute coronary syndrome (ACS) to achieve consistency with current knowledge in the field. This manuscript summarizes the key output from a collaborative workshop, organized by the Cardiovascular Round Table and the European Affairs Committee of the European Society of Cardiology, involving clinicians, academic researchers, trialists, European and US regulators, and pharmaceutical industry researchers...
June 29, 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/27307342/mechanically-isolated-stromal-vascular-fraction-provides-a-valid-and-useful-collagenase-free-alternative-technique-a-comparative-study
#13
Benoit Chaput, Nicolas Bertheuil, Marina Escubes, Jean-Louis Grolleau, Ignacio Garrido, Jérôme Laloze, Nicolas Espagnolle, Louis Casteilla, Luc Sensebé, Audrey Varin
BACKGROUND: The use of stromal vascular fraction and adipose-derived stromal cells in tissue regeneration is now being increasingly investigated, and studies have demonstrated that adipose-derived stromal cells present differentiation and immunomodulatory capacities. The development of a rapid, inexpensive, and enzyme-free technique to isolate adipose-derived stromal cell-enriched stromal vascular fraction is a major goal for stem cell therapy. Therefore, the authors compared innovative mechanical procedures to the gold standard technique, collagenase digestion...
October 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27270786/tp53-mutations-are-early-events-in-chronic-lymphocytic-leukemia-disease-progression-and-precede-evolution-to-complex-karyotypes
#14
Gregory Lazarian, Eugen Tausch, Virginie Eclache, Amel Sebaa, Vincent Bianchi, Remi Letestu, Jean-Francois Collon, Valerie Lefebvre, Laura Gardano, Nadine Varin-Blank, Thierry Soussi, Stephen Stilgenbauer, Florence Cymbalista, Fanny Baran-Marszak
TP53 abnormalities lead to resistance to purine analogues and are found in over 40% of patients with refractory chronic lymphocytic leukemia (CLL). At diagnosis, no more than 5% of patients carry the 17p deletion, most cases harbour mutations within the other TP53 allele. The incidence of a TP53 mutation as the only alteration is approximately 5%, but this depends on the sensitivity of the technique. Recently, having a complex karyotype has been considered a strong adverse prognostic factor. However, there are no longitudinal studies simultaneously examining the presence of the 17p deletion, TP53 mutations and karyotype abnormalities...
October 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27146375/spelling-errors-in-french-speaking-children-with-dyslexia-phonology-may-not-provide-the-best-evidence
#15
Daniel Daigle, Agnès Costerg, Anne Plisson, Noémia Ruberto, Joëlle Varin
For children with dyslexia, learning to write constitutes a great challenge. There has been consensus that the explanation for these learners' delay is related to a phonological deficit. Results from studies designed to describe dyslexic children's spelling errors are not always as clear concerning the role of phonological processes as those found in reading studies. In irregular languages like French, spelling abilities involve other processes than phonological processes. The main goal of this study was to describe the relative contribution of these other processes in dyslexic children's spelling ability...
December 0: Dyslexia: the Journal of the British Dyslexia Association
https://www.readbyqxmd.com/read/27127886/protein-kinase-d-dependent-cxcr4-down-regulation-upon-bcr-triggering-is-linked-to-lymphadenopathy-in-chronic-lymphocytic-leukaemia
#16
Stéphane Saint-Georges, Maude Quettier, Marouane Bouyaba, Stéphanie Le Coquil, Vanessa Laurienté, Lionel Guittat, Vincent Lévy, Florence Ajchenbaum-Cymbalista, Nadine Varin-Blank, Christine Le Roy, Dominique Ledoux
In Chronic Lymphocytic Leukemia (CLL), infiltration of lymph nodes by leukemic cells is observed in patients with progressive disease and adverse outcome. We have previously demonstrated that B-cell receptor (BCR) engagement resulted in CXCR4 down-regulation in CLL cells, correlating with a shorter progression-free survival in patients. In this study, we show a simultaneous down-regulation of CXCR4, CXCR5 and CD62L upon BCR triggering. While concomitant CXCR4 and CXCR5 down-regulation involves PKDs, CD62L release relies on PKC activation...
July 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/27100892/a-cardiac-mitochondrial-camp-signaling-pathway-regulates-calcium-accumulation-permeability-transition-and-cell-death
#17
Z Wang, D Liu, A Varin, V Nicolas, D Courilleau, P Mateo, C Caubere, P Rouet, A-M Gomez, G Vandecasteele, R Fischmeister, C Brenner
Although cardiac cytosolic cyclic 3',5'-adenosine monophosphate (cAMP) regulates multiple processes, such as beating, contractility, metabolism and apoptosis, little is known yet on the role of this second messenger within cardiac mitochondria. Using cellular and subcellular approaches, we demonstrate here the local expression of several actors of cAMP signaling within cardiac mitochondria, namely a truncated form of soluble AC (sACt) and the exchange protein directly activated by cAMP 1 (Epac1), and show a protective role for sACt against cell death, apoptosis as well as necrosis in primary cardiomyocytes...
2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27076174/tuning-of-akt-pathway-by-nef-and-its-blockade-by-protease-inhibitors-results-in-limited-recovery-in-latently-hiv-infected-t-cell-line
#18
Amit Kumar, Wasim Abbas, Laurence Colin, Kashif Aziz Khan, Sophie Bouchat, Audrey Varin, Anis Larbi, Jean-Stéphane Gatot, Kabamba Kabeya, Caroline Vanhulle, Nadège Delacourt, Sébastien Pasquereau, Laurie Coquard, Alexandra Borch, Renate König, Nathan Clumeck, Stephane De Wit, Olivier Rohr, Christine Rouzioux, Tamas Fulop, Carine Van Lint, Georges Herbein
Akt signaling plays a central role in many biological processes, which are key players in human immunodeficiency virus 1 (HIV-1) pathogenesis. We found that Akt interacts with HIV-1 Nef protein. In primary T cells treated with exogenous Nef or acutely infected with Nef-expressing HIV-1 in vitro, Akt became phosphorylated on serine(473) and threonine(308). In vitro, Akt activation mediated by Nef in T-cells was blocked by HIV protease inhibitors (PI), but not by reverse transcriptase inhibitors (RTI). Ex vivo, we found that the Akt pathway is hyperactivated in peripheral blood lymphocytes (PBLs) from cART naïve HIV-1-infected patients...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27036374/editor-s-choice-ex%C3%A2-vivo-renal-artery-repair-with-kidney-autotransplantation-for-renal-artery-branch-aneurysms-long-term-results-of-sixty-seven-procedures
#19
A Duprey, B Chavent, V Meyer-Bisch, T Varin, J-N Albertini, J-P Favre, X Barral, J-B Ricco
OBJECTIVE/BACKGROUND: To evaluate the long-term outcome of renal revascularization by ex vivo renal artery reconstruction and autotransplantation for renal artery branch aneurysms (RABAs). METHODS: Between 1991 and 2015, 67 ex vivo renal artery reconstructions with kidney autotransplantation were performed in 55 adults (mean age 47 years) and 10 children to repair 87 RABAs. The main underlying disease was fibromuscular dysplasia in 34 patients. Other etiologies were systemic congenital disease in eight patients, spontaneous dissecting aneurysms in five, iatrogenic aneurysms in three, atheromatous aneurysms in two and unknown etiology in 13...
June 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/26999633/endotypes-of-pollen-food-syndrome-in-children-with-seasonal-allergic-rhinoconjunctivitis-a-molecular-classification
#20
C Mastrorilli, S Tripodi, C Caffarelli, S Perna, A Di Rienzo-Businco, I Sfika, R Asero, A Dondi, A Bianchi, C Povesi Dascola, G Ricci, F Cipriani, N Maiello, M Miraglia Del Giudice, T Frediani, S Frediani, F Macrì, C Pistoletti, I Dello Iacono, M F Patria, E Varin, D Peroni, P Comberiati, L Chini, V Moschese, S Lucarelli, R Bernardini, G Pingitore, U Pelosi, R Olcese, M Moretti, A Cirisano, D Faggian, A Travaglini, M Plebani, M C Verga, M Calvani, P Giordani, P M Matricardi
BACKGROUND: Pollen-food syndrome (PFS) is heterogeneous with regard to triggers, severity, natural history, comorbidities, and response to treatment. Our study aimed to classify different endotypes of PFS based on IgE sensitization to panallergens. METHODS: We examined 1271 Italian children (age 4-18 years) with seasonal allergic rhinoconjunctivitis (SAR). Foods triggering PFS were acquired by questionnaire. Skin prick tests were performed with commercial pollen extracts...
August 2016: Allergy
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