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https://www.readbyqxmd.com/read/29353680/feedback-mechanisms-between-snow-and-atmospheric-mercury-results-and-observations-from-field-campaigns-on-the-antarctic-plateau
#1
Andrea Spolaor, Hélène Angot, Marco Roman, Aurélien Dommergue, Claudio Scarchilli, Massimiliano Vardè, Massimo Del Guasta, Xanthi Pedeli, Cristiano Varin, Francesca Sprovieri, Olivier Magand, Michel Legrand, Carlo Barbante, Warren R L Cairns
The Antarctic Plateau snowpack is an important environment for the mercury geochemical cycle. We have extensively characterized and compared the changes in surface snow and atmospheric mercury concentrations that occur at Dome C. Three summer sampling campaigns were conducted between 2013 and 2016. The three campaigns had different meteorological conditions that significantly affected mercury deposition processes and its abundance in surface snow. In the absence of snow deposition events, the surface mercury concentration remained stable with narrow oscillations, while an increase in precipitation results in a higher mercury variability...
January 5, 2018: Chemosphere
https://www.readbyqxmd.com/read/29331188/-care-pathway-and-life-course-of-drug-addicted-patients
#2
Franck Warembourg, Victoria Varin
Placing drug addicts, notably heroin addicts, at the centre of their care project, itself part of a life project, is the objective of the Le Lac d'Argent association in Annecy. Caregivers have been able to reflect on their practices and help to fight against preconceived ideas. This article presents the experience of a global support approach.
January 2018: Revue de L'infirmière
https://www.readbyqxmd.com/read/29310711/impact-of-collaborative-pharmaceutical-care-on-in-patients-medication-safety-study-protocol-for-a-stepped-wedge-cluster-randomized-trial-medrev-study
#3
Géraldine Leguelinel-Blache, Christel Castelli, Clarisse Roux-Marson, Sophie Bouvet, Sandrine Andrieu, Philippe Cestac, Rémy Collomp, Paul Landais, Bertrice Loulière, Christelle Mouchoux, Rémi Varin, Benoit Allenet, Pierrick Bedouch, Jean-Marie Kinowski
BACKGROUND: Clinical pharmaceutical care has long played an important role in the improvement of healthcare safety. Pharmaceutical care is a collaborative care approach, implicating all the actors of the medication circuit in order to prevent and correct drug-related problems that can lead to adverse drug events. The collaborative pharmaceutical care performed during patients' hospitalization requires two mutually reinforcing activities: medication reconciliation and medication review...
January 8, 2018: Trials
https://www.readbyqxmd.com/read/29258384/long-term-survival-after-multimodality-therapy-including-surgery-for-metastatic-esophageal-cancer
#4
Elke Van Daele, Vincenzo Scuderi, Eva Pape, Dirk Van de Putte, Oswald Varin, Yves Van Nieuwenhove, Wim Ceelen, Roberto Troisi, Piet Pattyn
BACKGROUND AND OBJECTIVES: Esophageal cancer (EC) remains an aggressive disease with a poor survival. Management of metastatic EC is limited to palliative chemotherapy (CT). Scientific contributions regarding the role of surgery are scarce and controversial. We analysed outcome of surgically treated metastatic EC patients. METHODS: We retrospectively identified surgically treated metastatic EC patients from our esophagectomy database. The aim of this study was to evaluate surgical complications, pathological response, oncological outcome and mean survival of these aggressively treated stage IV cancer patients...
December 19, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29107524/a-polyphenol-rich-cranberry-extract-reverses-insulin-resistance-and-hepatic-steatosis-independently-of-body-weight-loss
#5
Fernando F Anhê, Renato T Nachbar, Thibault V Varin, Vanessa Vilela, Stéphanie Dudonné, Geneviève Pilon, Maryse Fournier, Marc-André Lecours, Yves Desjardins, Denis Roy, Emile Levy, André Marette
OBJECTIVE: Previous studies have reported that polyphenol-rich extracts from various sources can prevent obesity and associated gastro-hepatic and metabolic disorders in diet-induced obese (DIO) mice. However, whether such extracts can reverse obesity-linked metabolic alterations remains unknown. In the present study, we aimed to investigate the potential of a polyphenol-rich extract from cranberry (CE) to reverse obesity and associated metabolic disorders in DIO-mice. METHODS: Mice were pre-fed either a Chow or a High Fat-High Sucrose (HFHS) diet for 13 weeks to induce obesity and then treated either with CE (200 mg/kg, Chow + CE, HFHS + CE) or vehicle (Chow, HFHS) for 8 additional weeks...
October 18, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29060435/symptom-based-data-preprocessing-for-the-detection-of-disease-outbreak
#6
Khanita Duangchaemkarn, Varin Chaovatut, Phongtape Wiwatanadate, Ekkarat Boonchieng
Early warning systems for outbreak detection is a challenge topic for researchers in the epidemiology and biomedical informatics fields. We are proposing a new method for detecting disease epidemics using a symptom-based approach. The data was collected from developed mobile applications which include users' demographic information and a list of chief complaint symptoms. Deliberated outbreaks are differentiated from seasonal outbreak by specific symptoms that represent a sign of infection. These symptoms were grouped, classified, and then converted to a time-series digital signal using the consensus scoring approach...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29055045/diagnostic-relevance-of-ige-sensitization-profiles-to-eight-recombinant-phleum-pratense-molecules
#7
Francesca Cipriani, Carla Mastrorilli, Salvatore Tripodi, Giampaolo Ricci, Serena Perna, Valentina Panetta, Riccardo Asero, Arianna Dondi, Annamaria Bianchi, Nunzia Maiello, Michele Miraglia Del Giudice, Tullio Frediani, Francesco Macrì, Sandra Lucarelli, Iride Dello Iacono, Maria Francesca Patria, Elena Varin, Diego Peroni, Loredana Chini, Viviana Moschese, Roberto Bernardini, Giuseppe Pingitore, Umberto Pelosi, Mariangela Tosca, Francesco Paravati, Ifigenia Sfika, Andrea Di Rienzo Businco, Calotta Povesi Dascola, Pasquale Comberiati, Simone Frediani, Caterina Lambiase, Maria Carmen Verga, Diego Faggian, Mario Plebani, Mauro Calvani, Carlo Caffarelli, Paolo Maria Matricardi
BACKGROUND: Grass pollen-related seasonal allergic rhinoconjunctivitis (SARg) is clinically heterogeneous in severity, comorbidities and response to treatment. The component-resolved diagnostics disclosed also a high heterogeneity at molecular level. Our study aimed at analyzing the characteristics of the IgE sensitization to Phleum pratense molecules and investigating the diagnostic relevance of such molecules in childhood. METHODS: We examined 1120 children (age 4-18y) with SARg...
October 20, 2017: Allergy
https://www.readbyqxmd.com/read/28873292/dose-exposure-simulation-for-piperacillin-tazobactam-dosing-strategies-in-infants-and-young-children
#8
Céline Thibault, Nastya Kassir, Yves Théorêt, France Varin, Catherine Litalien, Julie Autmizguine
BACKGROUND: Extended piperacillin-tazobactam (TZP) infusions have been associated with favourable outcomes. There are currently no pediatric dosing recommendations. OBJECTIVES: To determine appropriate TZP dosing strategies in children 2 months - 6 years according to age and different minimal inhibitory concentrations (MICs). METHODS: Age and weight were simulated for 1000 children. Post-hoc pharmacokinetic parameter estimates were generated using published clearance and volume of distribution data...
August 21, 2017: Journal of Population Therapeutics and Clinical Pharmacology
https://www.readbyqxmd.com/read/28836228/catherine-larr%C3%A3-re-rapha%C3%A3-l-larr%C3%A3-re-penser-et-agir-avec-la-nature-une-enqu%C3%A3%C2%AAte-philosophique-%C3%A3-ditions-la-d%C3%A3-couverte-coll-sciences-humaines-france-2015-374%C3%A2-pp-%C3%A2-14-99
#9
Héloïse Varin
No abstract text is available yet for this article.
September 2017: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/28791387/atelocollagen-mediated-in-vivo-sirna-transfection-in-ovarian-carcinoma-is-influenced-by-tumor-site-sirna-target-and-administration-route
#10
Matthieu Meryet-Figuière, Charlotte Lecerf, Emilie Varin, Jean-Luc Coll, Marie-Hélène Louis, Soizic Dutoit, Florence Giffard, Cécile Blanc-Fournier, Siham Hedir, Nicolas Vigneron, Emilie Brotin, Laurent Pelletier, Véronique Josserand, Christophe Denoyelle, Laurent Poulain
Ovarian cancer is the leading cause of death from gynecological malignancies worldwide, and innate or acquired chemoresistance of ovarian cancer cells is the major cause of therapeutic failure. It has been demonstrated that the concomitant inhibition of Bcl-xL and Mcl-1 anti-apoptotic activities is able to trigger apoptosis in chemoresistant ovarian cancer cells. In this context, siRNA-mediated Bcl‑xL and Mcl-1 inhibition constitutes an appealing strategy by which to eliminate chemoresistant cancer cells...
October 2017: Oncology Reports
https://www.readbyqxmd.com/read/28782710/use-of-nebulized-milrinone-in-cardiac-surgery-comparison-of-vibrating-mesh-and-simple-jet-nebulizers
#11
Paul Gavra, Maxime Laflamme, André Y Denault, Yves Théoret, Louis P Perrault, France Varin
Cardiopulmonary bypass triggers an ischemia-reperfusion injury with endothelial dysfunction in the pulmonary circulation which can result in pulmonary hypertension. Inhaled milrinone reduces this reperfusion phenomenon and two methods commonly available for administering it are simple jet and vibrating mesh nebulizations. However, neither their generated milrinone particle size profiles, nor their ability to aid endothelial relaxation have been compared. Simple jet and vibrating mesh particle size distributions of milrinone were verified through cascade impaction and their efficacy was tested on a cardiopulmonary bypass (CPB) swine model...
October 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28753152/comment-on-a-novel-method-of-human-adipose-derived-stem-cell-isolation-with-resultant-increased-cell-yield
#12
Jérôme Laloze, Nicolas Bertheuil, Julie Usseglio-Grosso, Audrey Varin, Benoit Chaput
No abstract text is available yet for this article.
July 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28744197/neuronal-cholesterol-accumulation-induced-by-cyp46a1-down-regulation-in-mouse-hippocampus-disrupts-brain-lipid-homeostasis
#13
Sophie Ayciriex, Fathia Djelti, Sandro Alves, Anne Regazzetti, Mathieu Gaudin, Jennifer Varin, Dominique Langui, Ivan Bièche, Eloise Hudry, Delphine Dargère, Patrick Aubourg, Nicolas Auzeil, Olivier Laprévote, Nathalie Cartier
Impairment in cholesterol metabolism is associated with many neurodegenerative disorders including Alzheimer's disease (AD). However, the lipid alterations underlying neurodegeneration and the connection between altered cholesterol levels and AD remains not fully understood. We recently showed that cholesterol accumulation in hippocampal neurons, induced by silencing Cyp46a1 gene expression, leads to neurodegeneration with a progressive neuronal loss associated with AD-like phenotype in wild-type mice. We used a targeted and non-targeted lipidomics approach by liquid chromatography coupled to high-resolution mass spectrometry to further characterize lipid modifications associated to neurodegeneration and cholesterol accumulation induced by CYP46A1 inhibition...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28719946/cell-assisted-lipotransfer-friend-or-foe-in-fat-grafting-systematic-review-and-meta-analysis
#14
REVIEW
J Laloze, A Varin, J Gilhodes, N Bertheuil, J L Grolleau, J Brie, J Usseglio, L Sensebe, T Filleron, B Chaput
BACKGROUND: Autologous fat grafting is a common procedure for soft-tissue reconstruction but is associated with a graft resorption rate ranging from 20% to 80%. To improve the fat graft survival rate, a new technique, called cell-assisted lipotransfer (CAL), was developed. With CAL, fat is injected along with adipose-derived stromal cells (ASCs) that are assumed to improve fat survival rate. We conducted an evidence-based meta-analysis to evaluate the efficacy and safety of CAL as compared with conventional autologous fat grafting (non-CAL)...
July 18, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28661333/acidogenesis-and-two-phase-codigestion-of-fats-oils-and-greases-and-municipal-biosolids
#15
Ross Varin, John Novak, Charles Bott
  Acidogenic codigestion of fats, oils, and greases (FOG) was studied using suspended growth sludge digesters operated as batch fed reactors that were fed twice daily. The digesters were maintained at a 2-day retention time and at 37 °C to mimic the acid phase of an acid-gas digestion system. As FOG loading rates increased, volatile fatty acid (VFA) production was found to increase, although the percentage of VFA production compared to theoretical values decreased exponentially to just 20% at the highest loading rates...
November 1, 2016: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28656887/corrupted-adipose-tissue-endogenous-myelopoiesis-initiates-diet-induced-metabolic-disease
#16
Elodie Luche, Virginie Robert, Vincent Cuminetti, Celine Pomié, Quentin Sastourné-Arrey, Aurélie Waget, Emmanuelle Arnaud, Audrey Varin, Elodie Labit, Patrick Laharrague, Remy Burcelin, Louis Casteilla, Beatrice Cousin
Activation and increased numbers of inflammatory macrophages, in adipose tissue (AT) are deleterious in metabolic diseases. Up to now, AT macrophages (ATM) accumulation was considered to be due to blood infiltration or local proliferation, although the presence of resident hematopoietic stem/progenitor cells (Lin-/Sca+/c-Kit+; LSK phenotype) in the AT (AT-LSK) has been reported. By using transplantation of sorted AT-LSK and gain and loss of function studies we show that some of the inflammatory ATM inducing metabolic disease, originate from resident AT-LSK...
June 28, 2017: ELife
https://www.readbyqxmd.com/read/28652100/current-role-for-radioisotope-synovectomy
#17
Vincent André, Vincent Dalibard, Emmanuelle Dernis, Stéphane Varin, Grégoire Cormier
Radioisotope synovectomy has been extensively used to treat patients with chronic inflammatory joint disease but has moved to a less prominent position since the introduction of new and highly effective drugs. Remaining indications are refractory synovitis, pigmented villonodular synovitis as an adjunct to surgery, and hemophilic arthropathy. The three main radioisotopes used are yttrium-90, rhenium-186, and erbium-189. Radioisotope synovectomy should be performed only by highly experienced professionals, to minimize the risk of injection-related complications...
June 23, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28651627/induction-of-endoplasmic-reticulum-calcium-pump-expression-during-early-leukemic-b-cell-differentiation
#18
Lamia Aït Ghezali, Atousa Arbabian, Hervé Roudot, Jean-Philippe Brouland, Fanny Baran-Marszak, Evelyn Salvaris, Andrew Boyd, Hans G Drexler, Agnes Enyedi, Remi Letestu, Nadine Varin-Blank, Bela Papp
BACKGROUND: Endoplasmic reticulum (ER) calcium storage and release play important roles in B lymphocyte maturation, survival, antigen-dependent cell activation and immunoglobulin synthesis. Calcium is accumulated in the endoplasmic reticulum (ER) by Sarco/Endoplasmic Reticulum Calcium ATPases (SERCA enzymes). Because lymphocyte function is critically dependent on SERCA activity, it is important to understand qualitative and quantitative changes of SERCA protein expression that occur during B lymphoid differentiation and leukemogenesis...
June 26, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28590968/mechanically-isolated-stromal-vascular-fraction-by-nanofat-emulsification-techniques
#19
LETTER
Nicolas Bertheuil, Audrey Varin, Raphael Carloni, Paul Girard, Benoit Chaput
No abstract text is available yet for this article.
September 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28587715/diffusion-weighted-whole-body-mri-for-evaluation-of-early-response-in-multiple-myeloma
#20
C Lacognata, F Crimì, A Guolo, C Varin, E De March, S Vio, A Ponzoni, G Barilà, A Lico, A Branca, E De Biasi, F Gherlinzoni, V Scapin, E Bissoli, T Berno, R Zambello
AIM: To evaluate the modifications of the apparent diffusion coefficient (ADC) in myelomatous lesions before and after induction treatment and the correlation with patient response to therapy according to International Myeloma Working Group (IMWG) criteria. MATERIALS AND METHODS: A homogeneous group of 18 patients with a diagnosis of symptomatic multiple myeloma who underwent whole-body MRI with diffusion-weighted imaging (DWI-MRI) before and after bortezomib-based induction chemotherapy were evaluated prospectively...
October 2017: Clinical Radiology
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