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https://www.readbyqxmd.com/read/28541531/the-affordability-of-minimally-invasive-procedures-in-major-lung-resection-a-prospective-study
#1
Henri Gondé, Marc Laurent, André Gillibert, Omar-Matthieu Sarsam, Rémi Varin, Gaël Grimandi, Christophe Peillon, Jean-Marc Baste
OBJECTIVES: Minimally invasive procedures are used for the surgical treatment of lung cancer. Two techniques are proposed: video-assisted thoracic surgery or robotic-assisted thoracic surgery. Our goal was to study the economic impact of our long-standing program for minimally invasive procedures for major lung resection. METHODS: We conducted a single-centre, 1-year prospective cost study. Patients who underwent lobectomy or segmentectomy were included. Patient characteristics and perioperative outcomes were collected...
May 25, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28495521/efficacy-of-local-glucocorticoid-after-local-anesthetic-in-bertolotti-s-syndrome-a-randomized-placebo-controlled-double-blind-trial
#2
Joëlle Glémarec, Stéphane Varin, Céline Cozic, Gilles Tanguy, Christelle Volteau, Philippe Montigny, Benoît Le Goff, Christelle Darrieutort Laffite C, Yves Maugars, Grégoire Cormier
OBJECTIVE: The primary objective of this study was to compare the efficacy of local injection of a local anesthetic with a glucocorticoid versus a local anesthetic with saline to treat low back pain due to lumbosacral transitional vertebras (LSTV) with a pseudoarticulation. METHODS: A randomized placebo-controlled double-blind study was conducted in patients with unilateral low back pain ascribed clinically to LSTV. Patients were randomized to lidocaine plus saline (LS group) or lidocaine plus cortivazol (LC group) injected locally under computed tomography guidance...
May 8, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28457726/cell-assisted-lipotransfer-current-concepts
#3
J Laloze, A Varin, N Bertheuil, J L Grolleau, C Vaysse, B Chaput
Autologous fat transfer, or lipofilling, is a common technique used for soft tissue reconstruction. It has been used for many years, but the technique is associated with a significant graft resorption rate (20% to 80%). To improve the fat graft survival rate, several methods have been tested, and one has appeared more promising: cell-assisted lipotransfer (CAL). In the CAL method, fat is enriched with adipose-derived stromal cells (ASC), contained in the stromal vascular fraction (SVF) obtained after enzymatic digestion of fat or after cell culture to improve the fat survival rate...
April 27, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28456381/high-prevalence-and-moderate-diversity-of-pseudomonas-aeruginosa-in-the-u-bends-of-high-risk-units-in-hospital
#4
Amélie Varin, Benoît Valot, Pascal Cholley, Camille Morel, Michelle Thouverez, Didier Hocquet, Xavier Bertrand
The presence of P. aeruginosa in water supply is clearly identified as a risk factor for P. aeruginosa infection in critical care units, even if routes of transmission are often unclear and remain a matter of debate. We determined here the frequency of U-bends contaminated with P. aeruginosa in high-risk units and described the population structure of this opportunistic pathogen in a non-outbreak situation. Eighty-seven U-bends from sinks of rooms in five wards were sampled 3 times and P. aeruginosa was detected in 121 of the 261 (46...
April 22, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28438331/-the-intestinal-microbiota-a-new-player-in-depression
#5
M Meyrel, L Varin, B Detaint, F Mouaffak
Depression is the leading cause of disability in the world according to the World Health Organization. The effectiveness of the available antidepressant therapies is limited. Data from the literature suggest that some subtypes of depression may be associated with chronic low grade inflammation. The uncovering of the role of intestinal microbiota in the development of the immune system and its bidirectional communication with the brain have led to growing interest on reciprocal interactions between inflammation, microbiota and depression...
April 21, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28356705/novel-splice-site-mutation-in-ttll5-causes-cone-dystrophy-in-a-consanguineous-family
#6
Miguel de Sousa Dias, Christian P Hamel, Isabelle Meunier, Juliette Varin, Steven Blanchard, Fiona Boyard, José-Alain Sahel, Christina Zeitz
PURPOSE: To report the clinical and genetic findings of one family with autosomal recessive cone dystrophy (CD) and to identify the causative mutation. METHODS: An institutional study of three family members from two generations. The clinical examination included best-corrected Snellen visual acuity measurement, fundoscopy, the Farnsworth D-15 color vision test, a full-field electroretinogram (ERG) that incorporated the International Society for Clinical Electrophysiology of Vision standards and methodology, fundus autofluorescence (FAF) and infrared (IR), and spectral-domain optical coherence tomography (SD-OCT)...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28335156/should-the-prediction-of-mortality-at-30-days-in-patients-treated-for-a-ruptured-abdominal-aortic-aneurysm-take-into-account-the-specialization-of-the-surgical-unit
#7
Ambroise Duprey, Thomas Varin, Charlène Hannequin, Fabien Heller, Caroline Haase-Ruby, Jean-Noël Albertini, Jean-Pierre Favre
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28330617/cd54-mediated-interaction-with-pro-inflammatory-macrophages-increases-the-immunosuppressive-function-of-human-mesenchymal-stromal-cells
#8
Nicolas Espagnolle, Adélie Balguerie, Emmanuelle Arnaud, Luc Sensebé, Audrey Varin
Mesenchymal stromal cells (MSCs) sense and modulate inflammation and represent potential clinical treatment for immune disorders. However, many details of the bidirectional interaction of MSCs and the innate immune compartment are still unsolved. Here we describe an unconventional but functional interaction between pro-inflammatory classically activated macrophages (M1MΦ) and MSCs, with CD54 playing a central role. CD54 was upregulated and enriched specifically at the contact area between M1MФ and MSCs. Moreover, the specific interaction induced calcium signaling and increased the immunosuppressive capacities of MSCs dependent on CD54 mediation...
April 11, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28224110/comparison-of-inhaled-milrinone-nitric-oxide-and-prostacyclin-in-acute-respiratory-distress-syndrome
#9
Martin Albert, Daniel Corsilli, David R Williamson, Marc Brosseau, Patrick Bellemare, Stéphane Delisle, Anne Qn Nguyen, France Varin
AIM: To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome (ARDS). METHODS: Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of iNO (20 ppm) or nebulized epoprostenol (10 μg/mL) was done in all patients...
February 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28219656/ultrasound-abnormalities-in-septic-arthritis-are-associated-with-functional-outcomes
#10
Emeline Gaigneux, Grégoire Cormier, Stéphane Varin, Oriane Mérot, Yves Maugars, Benoit Le Goff
OBJECTIVES: To describe the ultrasound abnormalities seen in septic arthritis and to assess their associations with clinical, biological, and radiological outcomes. METHODS: We prospectively included 34 patients with septic arthritis of a native joint (knee, n=19; shoulder, n=6; hip, n=4; ankle, n=3; or wrist, n=2). Ultrasonography was performed to record synovial-membrane thickness and vascularity, joint effusion, and abnormalities of adjacent soft tissues, at baseline then 4days, 2weeks, and 3months later...
February 17, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28099184/efficacy-of-vitamin-b6-in-lithium-associated-tremor-a-case-series
#11
Manuel Dias Alves, Laure Varin, Laura M Fiori, Bruno Etain, Jean-Michel Azorin, Raoul Belzeaux
No abstract text is available yet for this article.
January 18, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28068408/pharmacokinetics-of-lidocaine-hydrochloride-administered-with-or-without-adrenaline-for-the-paravertebral-brachial-plexus-block-in-dogs
#12
Amélie Choquette, Eric Troncy, Martin Guillot, France Varin, Jérôme R E Del Castillo
Adrenaline is known to prolong the duration of local anesthesia but its effects on the pharmacokinetic processes of local anesthetic drugs are not fully understood. Our objective was to develop a compartmental model for quantification of adrenaline's impact on the pharmacokinetics of perineurally-injected lidocaine in the dog. Dogs were subjected to paravertebral brachial plexus block using lidocaine alone or adrenalinated lidocaine. Data was collected through a prospective, randomised, blinded crossover protocol performed over three periods...
2017: PloS One
https://www.readbyqxmd.com/read/28054556/phosphorylation-impact-on-spleen-tyrosine-kinase-conformation-by-surface-enhanced-raman-spectroscopy
#13
Maximilien Cottat, Ryohei Yasukuni, Yo Homma, Nathalie Lidgi-Guigui, Nadine Varin-Blank, Marc Lamy de la Chapelle, Christine Le Roy
Spleen Tyrosine Kinase (Syk) plays a crucial role in immune cell signalling and its altered expression or activation are involved in several cancers. Syk activity relies on its phosphorylation status and its multiple phosphorylation sites predict several Syk conformations. In this report, we characterized Syk structural changes according to its phosphorylation/activation status by Surface Enhanced Raman Spectroscopy (SERS). Unphosphorylated/inactive and phosphorylated/active Syk forms were produced into two expression systems with different phosphorylation capability...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28002249/phenotypic-analysis-of-stromal-vascular-fraction-after-mechanical-shear-reveals-stress-induced-progenitor-populations
#14
Benoit Chaput, Jerome Laloze, Jean-Louis Grolleau, Nicolas Espagnolle, Nicolas Bertheuil, Audrey Varin
No abstract text is available yet for this article.
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27992693/scleroderma-peripheral-b-lymphocytes-secrete-interleukin-6-and-tgf-%C3%AE-and-activate-fibroblasts
#15
Nicolas Dumoitier, Benjamin Chaigne, Alexis Régent, Sébastien Lofek, Maïssa Mhibik, Peter Dorfmüller, Benjamin Terrier, Jonathan London, Alice Bérezné, Nicolas Tamas, Nadine Varin-Blank, Luc Mouthon
OBJECTIVE: To study the role of B lymphocytes in systemic sclerosis (SSc). PATIENTS AND METHODS: Peripheral B cell subpopulations, interleukin 6 (IL-6) and transforming growth factor-beta (TGF-β) productions were analyzed using flow cytometry and multiplex assay. Fibroblasts proliferation rate upon incubation with supernatants of B cells isolated from SSc patients or healthy controls (HC) was assessed using XTT, BrdU and Ki67. Collagen production was assessed using a collagen assay...
December 19, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27863673/laser-irradiation-to-produce-amorphous-pharmaceuticals
#16
Varin Titapiwatanakun, Junlathip Tankul, Abdul W Basit, Simon Gaisford
Using a high-power CO2 laser to irradiate powder beds, it was possible to induce phase transformation to the amorphous state. Irradiation of a model drug, indometacin, resulted in formation of a glass. Varying the settings of the laser (power and raster speed) was shown to change the physicochemical properties of the glasses produced and all irradiated glasses were found to be more stable than a reference glass produced by melt-quenching. Irradiation of a powder blend of paracetamol and polyvinylpyrrolidone K30 was found to produce a solid amorphous dispersion...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27825575/decreased-patient-exposure-to-ionizing-radiation-during-interventional-rheumatology-procedures-after-optimization-of-protection
#17
Céline Cozic, Fabien Audran, Christophe Blanchard, Christophe David, Vincent Andre, Michel Caulier, Stéphane Varin, Gilles Tanguy, Jérôme Dimet, Grégoire Cormier
OBJECTIVES: To decrease radiation exposure of patients undergoing interventional rheumatology procedures, without adversely affecting quality of care. METHODS: The radiation dose received, assessed by the dose-area product (DAP), was measured during 283 intraarticular injections performed under fluoroscopic guidance between May and July 2013. Then, three steps were taken to decrease patients' radiation exposure: a copper filter was added, the anti-scatter grid was removed, and exposure cell sensitivity was set at the highest value...
May 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27755299/reply-mechanical-isolation-of-stromal-vascular-fraction-a-new-advance-in-stem-cell-therapy
#18
Benoit Chaput, Nicolas Bertheuil, Jean-Louis Grolleau, Ignacio Garrido, Jerome Laloze, Audrey Varin
No abstract text is available yet for this article.
February 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27755297/concomitant-liposuction-reduces-complications-of-vertical-medial-thigh-lift-in-massive-weight-loss-patients
#19
Nicolas Bertheuil, Antoine de Runz, Audrey Varin, Raphael Carloni, Caroline Francois, Benoit Chaput
No abstract text is available yet for this article.
February 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27733868/insights-in-hypothesis-testing-and-making-decisions-in-biomedical-research
#20
Varin Sacha, Demosthenes B Panagiotakos
It is a fact that p values are commonly used for inference in biomedical and other social fields of research. Unfortunately, the role of p value is very often misused and misinterpreted; that is why it has been recommended the use of resampling methods, like the bootstrap method, to calculate the confidence interval, which provides more robust results for inference than does p value. In this review a discussion is made about the use of p values through hypothesis testing and its alternatives using resampling methods to develop confidence intervals of the tested statistic or effect measure...
2016: Open Cardiovascular Medicine Journal
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