Tássia Liz Araújo Dos Santos Lessa, Thiago Macêdo Lopes Correia, Talita Costa Dos Santos, Railmara Pereira da Silva, Beatriz Pereira da Silva, Maria Cláudia Magalhães Cavallini, Leonardo Silva Rocha, Albert Souza Peixoto, Beatriz S Cugnasca, Gustavo Cervi, Thiago C Correra, Augusto Cesar Gonçalves, William Tadeu Lara Festuccia, Thiago Mattar Cunha, Regiane Yatsuda, Amélia Cristina Mendes de Magalhães, Alcindo A Dos Santos, Flávia Carla Meotti, Raphael Ferreira Queiroz
Selenium-containing compounds have emerged as promising treatment for redox-based and inflammatory diseases. This study aimed to investigate the in vitro and in vivo anti-inflammatory activity of a novel diselenide named as dibenzyl[diselanediyIbis(propane-3-1diyl)] dicarbamate (DD). DD reacted with HOCl ( k = 9.2 x 107 M-1 s-1 ), like glutathione ( k = 1.2 x 108 M-1 s-1 ), yielding seleninic and selenonic acid derivatives, and it also decreased HOCl formation by activated human neutrophils (IC50 =4...
April 8, 2024: Free Radical Research