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https://www.readbyqxmd.com/read/28533327/serum-amyloid-a-an-ozone-induced-circulating-factor-with-potentially-important-functions-in-the-lung-brain-axis
#1
Michelle A Erickson, Joseph Jude, Hengjiang Zhao, Elizabeth M Rhea, Therese S Salameh, William Jester, Shelley Pu, Jenna Harrowitz, Ngan Nguyen, William A Banks, Reynold A Panettieri, Kelly L Jordan-Sciutto
Accumulating evidence suggests that O3 exposure may contribute to CNS dysfunction. Here, we posit that inflammatory and acute-phase proteins in the circulation increase after O3 exposure and systemically convey signals of O3 exposure to the CNS. To model acute O3 exposure, female Balb/c mice were exposed to 3 ppm O3 or forced air for 2 h and were studied after 6 or 24 h. Of 23 cytokines and chemokines, only KC/CXCL1 was increased in blood 6 h after O3 exposure. The acute-phase protein serum amyloid A (A-SAA) was significantly increased by 24 h, whereas C-reactive protein was unchanged...
May 22, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28521677/molluscum-contagiosum-an-update
#2
Alexander Kc Leung, Benjamin Barankin, Kam Lun Hon
BACKGROUND: Molluscum contagiosum is a viral cutaneous infection in childhood that occurs worldwide. Physicians should familiarize themselves with this common condition. OBJECTIVE: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications and, in particular, treatment of molluscum contagiosum. METHODS: A PubMed search was completed in Clinical Queries using the key term "molluscum contagiosum". Patents were searched using the key term "molluscum contagiosum" from www...
May 17, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28515172/cross-sex-transplantation-alters-gene-expression-and-enhances-inflammatory-response-in-the-transplanted-kidneys
#3
Lei Wang, Jiangping Song, Shaohui Wang, Jacentha Buggs, Rongjun Chen, Jie Zhang, Liqing Wang, Song Rong, Wenbin Li, Jin Wei, Ruisheng Liu
Kidney transplantation (KTX) is a life-saving procedure for patients with end-stage renal disease. Expression levels of many genes in kidney vary between males and females which may play an essential role in the sex differences in graft function. However, whether these differences are affected after cross-sex-KTX is unknown. In the present study, we assessed post-operative changes in genotype, function and inflammatory responses of the grafts in same-sex and cross-sex-KTX. Single kidney transplants were performed between same and different sex C57BL/6 mice paired into 4 combination groups: female donor/female recipient (F/F); male donor/male recipient (M/M); female donor/male recipient (F/M); and male donor/female recipient (M/F)...
May 17, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28508644/normal-leveled-and-enhanced-steric-effects-in-alkoxyamines-carrying-a-%C3%AE-phosphorylated-nitroxyl-fragment
#4
Gérard Audran, Raphael Bikanga, Paul Brémond, Jean-Patrick Joly, Sylvain R A Marque, Paulin Nkolo
The design of new R1R2NOR3 alkoxyamines for various applications relies on the accurate prediction of two kinetic parameters, the C-ON bond homolysis rate constant (kd) and its re-formation rate constant (kc). Relationships to describe the steric and polar effects of the R1R2NO fragment ruling kd have been developed. For all cyclic nitroxyl fragments, the steric effect is described as the sum of the bulkiness of the R1 and R2 groups (i.e., normal steric effect), while for the noncyclic nitroxyl fragment (except for one case), a leveled steric effect is assumed...
May 16, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28507952/comparison-of-growth-and-the-cytokines-induced-by-pathogenic-yersinia-enterocolitica-bio-serotypes-3-o-3-and-2-o-9
#5
Haoshu Yang, Wenpeng Gu, Haiyan Qiu, Guixiang Sun, Junrong Liang, Kewei Li, Yuchun Xiao, Ran Duan, Huaiqi Jing, Xin Wang
Pathogenic Yersinia enterocolitica is widely distributed in China where the primary bio-serotypes are 3/O: 3 and 2/O: 9. Recently, the distribution of 2/O: 9 strains are being gradually replaced by 3/O: 3 strains where presently 3/O: 3 strains are the major pathogenic Y. enterocolitica in China. To identify the growth conditions and cytokines induced by Y. enterocolitica and providing some clues for this shift, we performed competitive growth in vitro and in vivo for these two bio-serotype strains; and we also compared the cytokines induced by them in infected BALB/C mice...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28507167/early-activation-of-deleterious-molecular-pathways-in-the-kidney-in-experimental-heart-failure-with-atrial-remodeling
#6
Tomoko Ichiki, Brenda K Huntley, Gail J Harty, S Jeson Sangaralingham, John C Burnett
Heart failure (HF) is a major health problem with worsening outcomes when renal impairment is present. Therapeutics for early phase HF may be effective for cardiorenal protection, however the detailed characteristics of the kidney in early-stage HF (ES-HF), and therefore treatment for potential renal protection, are poorly defined. We sought to determine the gene and protein expression profiles of specific maladaptive pathways of ES-HF in the kidney and heart. Experimental canine ES-HF, characterized by de-novo HF with atrial remodeling but not ventricular fibrosis, was induced by right ventricular pacing for 10 days...
May 2017: Physiological Reports
https://www.readbyqxmd.com/read/28505148/potential-pathogenesis-and-biomarkers-of-kidney-cancer-related-stroke
#7
Haihong Jiang, Chao Qin, Daobin Cheng, Qiuhong Lu, Gelun Huang, Dacheng Wang, Hong Yang, Zhijian Liang
BACKGROUND Stroke risk and stroke recurrence are increased in cancer patients, but the pathogenesis and biomarkers of kidney cancer-related stroke (KCS) are generally unclear. The aim of the present research was to investigate the pathogenesis and plasma biomarkers of kidney cancer-related stroke. MATERIAL AND METHODS A retrospective review was conducted on acute stroke patients with kidney cancer (KC) who were admitted to the hospital between January 2006 and December 2015. A total of 106 patients with KCS (active KC patients with acute stroke but without conventional vascular risks) were identified...
May 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28504158/influence-of-osmotic-and-weight-pressure-on-water-release-from-polysaccharide-ionic-gels
#8
Komla Ako
Kappa-carrageenan (kC) is a polyelectrolyte biopolymer that forms gels if the kC concentration, the salt and the temperature are adequately chosen. Actually, under certain conditions, kC gels release water in a process called syneresis. In this contribution, the syneresis of gels containing 2g/L of kC has been studied as a function of potassium chloride concentration [KCl]. The syneresis decreases if the [KCl] is increased in the biopolymer solution (sol) before the gelation but increases if the [KCl] is increased after gelation by immersing the gels in KCl solution...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28501441/repeatability-of-topographic-corneal-thickness-in-keratoconus-comparing-visante%C3%A2-oct-and-oculus-pentacam-hr-%C3%A2-topographer
#9
Heinz Otchere, Luigina Sorbara
PURPOSE: To assess the repeatability and reproducibility of Visante™ OCT and Oculus Pentacam HR® in measuring central (CCT) and topographic corneal thickness (TCT) along the principle meridians in keratoconus (KC) corneae. METHOD: Twenty participants diagnosed with KC were recruited. There were two study visits. On the first study visit, two repeated corneal thickness measurements were obtained with each instrument. Measurements were repeated at least 48hrs later in the same order...
May 10, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28500337/examining-the-efficacy-of-intravenous-administration-of-predatory-bacteria-in-rats
#10
Kenneth Shatzkes, Eric Singleton, Chi Tang, Michael Zuena, Sean Shukla, Shilpi Gupta, Sonal Dharani, Joseph Rinaggio, Daniel E Kadouri, Nancy D Connell
The proteobacteria Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus are obligate predators of Gram-negative bacteria, and have been proposed to be used to treat multidrug-resistant bacterial infections. The ability of predatory bacteria to reduce bacterial burden in vivo within the lungs of rats has been demonstrated, but it was unknown if predatory bacteria can attenuate systemic bacterial burden administered intravenously. In this study, we first assessed the safety of intravenous inoculation of predatory bacteria in rats...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28500084/bisphenol-a-promotes-hepatic-lipid-deposition-involving-kupffer-cell-m1-polarization-in-male-mice
#11
Qiong Lv, Rufei Gao, Chuan Peng, Juan Yi, Lulu Liu, Shumin Yang, Danting Li, Jinbo Hu, Ting Luo, Mei Mei, Ying Song, Chaodong Wu, Xiaoqiu Xiao, Qifu Li
Bisphenol A (BPA), as one of the most common environmental endocrine disruptors, is considered to promote hepatic lipid deposition, but the mechanisms has not been fully elucidated. The polarization of Kupffer cells (KCs) plays an important role in hepatic inflammation by promoting pro-inflammatory M1 phenotype (M1KCs), which contributes to dysregulated lipid metabolism. The purpose of this study is to investigate the role of KC polarization in BPA-induced hepatosteatosis in male mice. In this study, we examined hepatic lipid contents and quantified M1KC in BPA-treated CD1 mice, and further explored the interaction between KCs and hepatocytes by using conditional HepG2 cell culture...
May 12, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28495448/nrf2-in-keratinocytes-modulates-uvb-induced-dna-damage-and-apoptosis-in-melanocytes-through-mapk-signaling
#12
Saowanee Jeayeng, Adisak Wongkajornsilp, Andrzej T Slominski, Siwanon Jirawatnotai, Somponnat Sampattavanich, Uraiwan Panich
Responses of melanocytes (MC) to ultraviolet (UV) irradiation can be influenced by their neighbouring keratinocytes (KC). We investigated the role of Nrf2 in regulating paracrine effects of KC on UVB-induced MC responses through phosphorylation of MAPKs in association with oxidative stress in primary human MC cocultured with primary human KC using a transwell co-culture system and small-interfering RNA-mediated silencing of Nrf2 (siNrf2). The mechanisms by which Nrf2 modulated paracrine factors including α-melanocyte-stimulating hormone (α-MSH) and paracrine effects of KC on UVB-mediated apoptosis were also assessed...
May 8, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28494399/comparative-toxic-responses-of-male-and-female-lizards-eremias-argus-exposed-to-s-metolachlor-contaminated-soil
#13
Li Chen, Dezhen Wang, Zhongnan Tian, Shanshan Di, Wenjun Zhang, Fang Wang, Zhiqiang Zhou, Jinling Diao
Soil contamination caused by the widespread use of pesticides is one of the main environmental problems facing conservation organizations. (S)-metolachlor (SM) is a selective pre-emergent herbicide that poses potential risks to soil-related organisms such as reptiles. The present study elucidated the toxic effects of SM (3 and 30 mg/kg soil weight) in Eremias argus. The results showed that growth pattern was similar between the sexes in breeding season. For males, both kidney coefficient (KC) and testis coefficient in the exposure group were significantly different from those in the control group, while only KC in the high-dose group was significantly higher for females...
May 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28493563/nalmefene-prevents-alcohol-induced-neuroinflammation-and-alcohol-drinking-preference-in-adolescent-female-mice-role-of-tlr4
#14
Jorge Montesinos, Anabel Gil, Consuelo Guerri
BACKGROUND: We previously showed that, by activating innate immune receptors toll-like 4 (TLR4), adolescent intermittent ethanol exposure causes neuroinflammation, myelin damage and behavioral dysfunctions. Recent findings reveal that clinically-used opioid antagonists naltrexone (NT) and naloxone (NX) inhibit opioid-induced TLR4 signaling, and that NT, NX and nalmefene (NF), the 6-methylene derivative of NX, are able to reduce alcohol drinking escalation. METHODS: NF (0...
May 11, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28490820/the-end-of-hypergamy-global-trends-and-implications
#15
Albert Esteve, Christine R Schwartz, Jan Van Bavel, Iñaki Permanyer, Martin Klesment, Joan Garcia
The gender gap in education that has long favored men has reversed for young adults in almost all high and middle-income countries. In 2010, the proportion of women aged 25-29 with a college education was higher than that of men in more than 139 countries which altogether represent 86% of the world's population. According to recent population forecasts, women will have more education than men in nearly every country in the world by 2050, with the exception of only a few African and West Asian countries (KC et al...
December 2016: Population and Development Review
https://www.readbyqxmd.com/read/28490621/plasma-7-ketocholesterol-levels-and-the-risk-of-incident-cardiovascular-events
#16
Min Wang, Weiqing Long, Di Li, Duan Wang, Yuan Zhong, Di Mu, Jiayi Song, Min Xia
OBJECTIVE: 7-Ketocholesterol (7-KC), a major oxidation product of cholesterol, is found in human atherosclerotic plaque and more atherogenic than cholesterol in animal models. This study was designed to investigate the association of plasma 7-KC level with the incident cardiovascular disease (CVD) events in general population. METHODS: We measured plasma 7-KC concentrations at baseline in 1944 participants free from CVD in a community-based cohort study. The primary endpoint was incident of a major adverse cardiovascular event...
May 10, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28484742/serum-cytokine-levels-are-related-to-nesfatin-1-nucb2-expression-in-the-implantation-sites-of-spontaneous-abortion-model-of-cba-j-%C3%A3-dba-2-mice
#17
Yiwa Chung, Heejeong Kim, Sojeong Seon, Hyunwon Yang
The process of spontaneous abortion involves a complex mechanism with various cytokines, growth factors, and hormones during the pregnancy. However, the mechanism underlying spontaneous abortion by pro- and anti-inflammatory cytokines in the serum during the pregnancy is not fully understood. Therefore, the purpose of this study was to examine the relationship between the serum levels of pro- and anti-inflammatory cytokines and spontaneous abortion using the CBA/j × DBA/2 mouse model. Serum levels of pro-inflammatory cytokines, such as IFN-γ, IL-1α and TNF-α were not increased in abortion model mice, but anti-inflammatory cytokines, such as IL-4, IL-13 and IL-1ra were decreased compared to normal pregnant mice...
March 2017: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/28484309/identification-of-seven-novel-znf469-mutations-in-keratoconus-patients-in-a-han-chinese-population
#18
Xiaoning Yu, Binbin Chen, Xin Zhang, Xingchao Shentu
PURPOSE: To test for the potential presence of novel mutations in the zinc finger protein (ZNF469) gene in patients with sporadic keratoconus (KC) from a Han Chinese population. METHODS: Fifty-three patients with primary KC, 30 patients with high myopia (HM), and 100 unrelated population-matched healthy controls without any ocular or systemic disorders, all of Han Chinese ethnicity, were recruited. Blood samples were donated, and genomic DNA was isolated from peripheral blood leukocytes...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28482996/culturally-adaptive-walking-intervention-for-korean-chinese-female-migrant-workers
#19
Sunghye Cho, Hyeonkyeong Lee, Jung Hee Kim, Meenhye Lee, Young-Me Lee
BACKGROUND AND PURPOSE: Although the literature has commonly cited that development of culturally adaptive interventions is key to improving the health outcomes of culturally and linguistically diverse populations, there have been limited culturally adaptive walking interventions specific to Korean-Chinese (KC) migrants. The objective of this study is to describe the process in development of culturally adaptive walking interventions for KC female migrant workers, using the intervention mapping (IM) method...
May 1, 2017: Research and Theory for Nursing Practice
https://www.readbyqxmd.com/read/28479621/increased-immunization-coverage-addresses-the-equity-gap-in-nepal
#20
Ashish Kc, Viktoria Nelin, Hendrikus Raaijmakers, Hyung Joon Kim, Chahana Singh, Mats Målqvist
OBJECTIVE: To compare immunization coverage and equity distribution of coverage between 2001 and 2014 in Nepal. METHODS: We used data from the Demographic and Health Surveys carried out in 2001, 2006 and 2011 together with data from the 2014 Multiple Indicator Cluster Survey. We calculated the proportion, in mean percentage, of children who had received bacille Calmette-Guérin (BCG) vaccine, three doses of polio vaccine, three doses of diphtheria-pertussis-tetanus (DPT) vaccine and measles vaccine...
April 1, 2017: Bulletin of the World Health Organization
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