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https://www.readbyqxmd.com/read/29147443/4-nitroquinoline-1-oxide-induced-tongue-and-esophagus-carcinogenesis-in-obese-and-diabetic-tsod-mice
#1
Takuji Tanaka, Kunihiro Kawabata, Shigeyuki Sugie
Background: Obesity and diabetes mellitus are associated with lifestyle-related carcinogenesis. They are also risk factors of esophageal adenocarcinoma, but there are only a few reports on association between obesity/diabetes and development of squamous cell carcinoma in the oral cavity and esophagus. In this study, we therefore aimed to determine whether obesity and diabetes affect oral and esophageal carcinogenesis using model mice of obesity and diabetes, the Tsumura Suzuki obese diabetes (TSOD) and Tsumura Suzuki non-obesity (TSNO) control mice, which were treated with 4-nitroquinoline 1-oxide (4-NQO) to produce tongue and esophageal carcinomas...
August 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29142326/complex-organic-molecules-in-strongly-uv-irradiated-gas
#2
S Cuadrado, J R Goicoechea, J Cernicharo, A Fuente, J Pety, B Tercero
We investigate the presence of complex organic molecules (COMs) in strongly UV-irradiated interstellar molecular gas. We have carried out a complete millimetre (mm) line survey using the IRAM 30 m telescope towards the edge of the Orion Bar photodissociation region (PDR), close to the H2 dissociation front, a position irradiated by a very intense far-UV (FUV) radiation field. These observations have been complemented with 8.5″ resolution maps of the H2CO JKa,Kc = 51,5 → 41,4 and C(18)O J = 3 → 2 emission at 0...
July 2017: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/29141739/advancing-global-health-through-development-and-clinical-trials-partnerships-a-randomized-placebo-controlled-double-blind-assessment-of-safety-tolerability-and-immunogenicity-of-plasmodium-falciparum-sporozoites-vaccine-for-malaria-in-healthy-equatoguinean
#3
Ally Olotu, Vicente Urbano, Ali Hamad, Martin Eka, Mwajuma Chemba, Elizabeth Nyakarungu, Jose Raso, Esther Eburi, Dolores O Mandumbi, Dianna Hergott, Carl D Maas, Mitoha O Ayekaba, Diosdado N Milang, Matilde R Rivas, Tobias Schindler, Oscar M Embon, Adam J Ruben, Elizabeth Saverino, Yonas Abebe, Natasha Kc, Eric R James, Tooba Murshedkar, Anita Manoj, Sumana Chakravarty, Minglin Li, Matthew Adams, Chris Schwabe, Luis Segura, Claudia Daubenberger, Marcel Tanner, Thomas L Richie, Peter F Billingsley, B Kim Lee Sim, Salim Abdulla, Stephen L Hoffman
Equatorial Guinea (EG) has implemented a successful malaria control program on Bioko Island. A highly effective vaccine would be an ideal complement to this effort and could lead to halting transmission and eliminating malaria. Sanaria(®)Plasmodium falciparum sporozoites (PfSPZ) Vaccine is being developed for this purpose. To begin the process of establishing the efficacy of and implementing a PfSPZ Vaccine mass vaccination program in EG, we decided to conduct a series of clinical trials of PfSPZ Vaccine on Bioko Island...
October 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29133633/altered-tear-inflammatory-profile-in-indian-keratoconus-patients-the-2015-col-rangachari-award-paper
#4
Rohit Shetty, Rashmi Deshmukh, Arkasubhra Ghosh, Swaminathan Sethu, Chaitra Jayadev
PURPOSE: Conventionally, keratoconus (KC) has been considered a noninflammatory corneal ectatic disorder. Recent evidence suggests a possible role of inflammation in the pathogenesis of KC. Hence, we analyzed the levels of inflammatory factors in the tear fluid of Indian KC patients. METHODS: Tear fluid samples were collected from age- and sex-matched healthy controls and KC patients (with different grades). The levels of the inflammatory factors in tears were analyzed using cytometric bead array (Human Soluble Protein Flex Set System, BD Biosciences) for levels of interleukin-1α (IL-1α), IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-9, IL-10, IL-12p70, IL-23p40, IL-13, IL-17A, IL-17F, IL-21, interferon-α (IFNα), IFNγ, tumor necrosis factor-α, CCL2/monocyte chemotactic protein-1, CCL4/macrophage inflammatory protein-1β (MIP-1β), MIP-1α, CCL5/RANTES, CXCL10/IP10, ICAM1, CD62E, vascular endothelial growth factor and transforming growth factor β...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29132103/fixed-bed-column-studies-of-total-organic-carbon-removal-from-industrial-wastewater-by-use-of-diatomite-decorated-with-polyethylenimine-functionalized-pyroxene-nanoparticles
#5
Afif Hethnawi, Abdallah D Manasrah, Gerardo Vitale, Nashaat N Nassar
In this study, a fixed-bed column adsorption process was employed to remove organic pollutants from a real industrial wastewater effluent using polyethylenimine-functionalized pyroxene nanoparticles (PEI-PY) embedded into Diatomite at very low mass percentage. Various dynamic parameters (e.g., inlet concentration, inlet flow rate, bed height, and PEI-nanoparticle concentration in Diatomite, (%nps)) were investigated to determine the breakthrough behavior. The obtained breakthrough curves were fit with a convection-dispersion model to determine the characteristic parameters based on mass transfer phenomena...
November 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29130025/epidemiology-of-keratinocyte-carcinoma
#6
David M Perry, Virginia Barton, Anthony J Alberg
Purpose of the review: To provide a synopsis of recent research advances in the epidemiology of keratinocyte carcinoma (KC), with a focus on indoor tanning and known risk factors for other forms of cancer such as cigarette smoking and alcohol drinking. Recent findings: The evidence is strong enough to infer that use of UVR-emitting indoor tanning devices cause KC. Epidemiologic studies of cigarette smoking, alcohol drinking, and menopausal hormone therapy all show some suggestion for increased risk of KC but the evidence is not yet strong enough to determine if there is a true etiologic role...
September 2017: Current Dermatology Reports
https://www.readbyqxmd.com/read/29129979/hair-germ-model-in-vitro-via-human-postnatal-keratinocyte-dermal-papilla-interactions-impact-of-hyaluronic-acid
#7
Ekaterina Kalabusheva, Vasily Terskikh, Ekaterina Vorotelyak
Hair follicle (HF) reconstruction in vitro is a promising field in alopecia treatment and human HF development research. Here, we combined postnatal human dermal papilla (DP) cells and skin epidermal keratinocytes (KCs) in a hanging drop culture to develop an artificial HF germ. The method is based on DP cell hair-inducing properties and KC self-organization. We evaluated two protocols of aggregate assembling. Mixed HF germ-like structures demonstrated the initiation of epithelial-mesenchymal interaction, including WNT pathway activation and expression of follicular markers...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29129750/k-complex-morphological-features-in-male-obstructive-sleep-apnea-hypopnea-syndrome-patients
#8
Lin Sun, Xiangmin Zhang, Shaoxiong Huang, Jiuxing Liang, Yuxi Luo
This study characterized the differences in K-complex (KC) morphology features between obstructive sleep apnea-hypopnea syndrome (OSAHS) patients and healthy controls and analyzed the effect of respiratory events on KC morphology. We enrolled 42 male subjects (21 OSAHS patients and 21 age-matched healthy controls) who underwent overnight polysomnography. KCs in stage N2 were manually identified. We found that KCs in healthy controls had larger negative and whole amplitudes, longer durations, and smoother positive waves than OSAHS patients but smaller positive amplitudes...
November 9, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29128955/right-brodmann-area-18-predicts-tremor-arrest-after-vim-radiosurgery-a-voxel-based-morphometry-study
#9
Constantin Tuleasca, Tatiana Witjas, Dimitri Van de Ville, Elena Najdenovska, Antoine Verger, Nadine Girard, Jerome Champoudry, Jean-Philippe Thiran, Meritxell Bach Cuadra, Marc Levivier, Eric Guedj, Jean Régis
INTRODUCTION: Drug-resistant essential tremor (ET) can benefit from open standard stereotactic procedures, such as deep-brain stimulation or radiofrequency thalamotomy. Non-surgical candidates can be offered either high-focused ultrasound (HIFU) or radiosurgery (RS). All procedures aim to target the same thalamic site, the ventro-intermediate nucleus (e.g., Vim). The mechanisms by which tremor stops after Vim RS or HIFU remain unknown. We used voxel-based morphometry (VBM) on pretherapeutic neuroimaging data and assessed which anatomical site would best correlate with tremor arrest 1 year after Vim RS...
November 11, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29127992/leishmania-infantum-exerts-immunomodulation-in-canine-kupffer-cells-reverted-by-meglumine-antimoniate
#10
A Rodrigues, D Santos-Mateus, G Alexandre-Pires, A Valério-Bolas, M Rafael-Fernandes, M A Pereira, D Ligeiro, J de Jesus, R Alves-Azevedo, S Lopes-Ventura, M Santos, A M Tomás, I Pereira da Fonseca, G Santos-Gomes
Kupffer cells (KC) are the liver macrophage population that resides in the hepatic sinusoids and efficiently phagocyte pathogens by establishing an intimate contact with circulating blood. KC constitute the liver host cells in Leishmania infection, nevertheless little is described about their role, apart from their notable contribution in granulomatous inflammation. The present study aims to investigate how canine KC sense and react to the presence of Leishmania infantum promastigotes and amastigotes by evaluating the gene expression of specific innate immune cell receptors and cytokines, as well as the induction of nitric oxide and urea production...
December 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/29122013/suppression-of-methylmercury-induced-mip-2-expression-by-n-acetyl-l-cysteine-in-murine-raw264-7-macrophage-cell-line
#11
Juliet David, Athira Nandakumar, Muflihatul Muniroh, Suminori Akiba, Megumi Yamamoto, Chihaya Koriyama
BACKGROUND: The aim of this study is to examine the inflammatory-cytokine expressions in the presence of non-cytotoxic dose of methylmercury (MeHg) in murine macrophages, which is suspected to play an important role in brain damage caused by MeHg exposure. We focused on murine macrophage inflammatory protein-2 (MIP-2), keratinocyte chemoattractant (KC), and monocyte chemoattractant protein-5 (MCP-5). MIP-2 and KC are murine functional homologues of human IL-8 and MCP-5 for human MCP-1...
November 9, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29120713/waveform-analysis-of-deformation-amplitude-and-deflection-amplitude-in%C3%A2-normal-suspect-and-keratoconic-eyes
#12
Mathew Francis, Natasha Pahuja, Rushad Shroff, Roshan Gowda, Himanshu Matalia, Rohit Shetty, Everette J Remington Nelson, Abhijit Sinha Roy
PURPOSE: To evaluate the performance of waveform-derived variables in distinguishing normal, suspect, and keratoconic eyes. SETTING: Narayana Nethralaya Eye Hospital, Bangalore, India. DESIGN: Retrospective case series. METHODS: Scheimpflug tomography (Pentacam) and dynamic Scheimpflug analysis (Corvis ST) of 253 normal (253 patients) eyes and 205 keratoconic eyes (205 patients) were evaluated. Among the 205 patients, 62 had keratoconus in 1 eye, while the unaffected eye was suspect...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29116065/-immunogenicity-of-recombinant-analog-of-antitumor-protein-lactaptin
#13
A V Tkachenko, O S Troitskaya, D V Semenov, E V Dmitrienko, E V Kuligina, V A Richter, O A Koval
Therapeutic monoclonal antibodies and recombinant proteins including cytokines are commonly used in the treatment of cancer and inflammatory diseases. In most cases, these protein-based drugs exhibit a high therapeutic efficacy, which is unfortunately frequently associated with a variety of side effects. We have investigated the in vitro and in vivo immunogenicity of recombinant antitumor protein lactaptin (RL2). Based on the qRT-PCR analysis, we have shown that, in MDA-MB-231 human breast adenocarcinoma cells, RL2 suppresses the NF-kB signaling cascade that regulates the reactions of innate immunity...
September 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29115640/off%C3%A2-target-effect-of-imatinib-and-nilotinib-on-human-vitamin-d3-metabolism
#14
Lysann Kroschwald, Meinolf Suttorp, Josephine Tabea Tauer, Nick Zimmermann, Claudia Günther, Andrea Bauer
Prolonged treatment with tyrosine kinase inhibitors (TKI) including imatinib (IMA) or nilotinib (NIL), induces severe disturbances of bone metabolism in patients with chronic myeloid leukaemia. As vitamin D3 (VD3) is involved in the complex cycle of bone remodelling, the present study investigated in vitro, the influence of IMA and NIL on VD3 metabolism i) in HaCaT cells and ii) in cultured outer root sheath keratinocytes (ORS‑KC) from hair follicles of IMA treated children. Cells were incubated in the presence of IMA or NIL...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29111844/a-new-perspective-on-the-genetics-of-keratoconus-why-have-we-not-been-more-successful
#15
Hanne Valgaeren, Carina Koppen, Guy Van Camp
Twin studies and family studies suggest an important genetic basis for keratoconus (KC). Involvement and association of several genes with the disease has been reported. Additionally, genes associated with central corneal thickness (CCT) and corneal curvature (CC) via genome-wide association studies (GWAS), also potentially underlie KC. Although a long list of genes has been reported for KC, the evidence for a pathogenic role for most genes remains limited. Furthermore, if the involvement of the reported genes in KC development can be proven, they only account for a limited number of patients...
November 7, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29111158/non-alcoholic-steatohepatitis-induces-transient-changes-within-the-liver-macrophage-pool
#16
Lindsey Devisscher, Charlotte L Scott, Sander Lefere, Sarah Raevens, Eliene Bogaerts, Annelies Paridaens, Xavier Verhelst, Anja Geerts, Martin Guilliams, Hans Van Vlierberghe
Kupffer cells (KCs) and monocyte-derived macrophages are implicated in non-alcoholic steatohepatitis (NASH) pathogenesis but their functions remain unclear due to the lack of specific markers to distinguish between the different cell types. Additionally, it is unclear if multiple subsets of KCs are present during NASH. Here, we characterized the liver macrophage subsets during methionine/choline deficient (MCD) diet-induced NASH and recovery. We observed a significant reduced contribution of Ly6C(lo)Clec4F(+)Tim4(+)KCs to the hepatic macrophage pool in MCD fed mice, which normalized during recovery...
October 16, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29103523/structural-features-and-water-sorption-isotherms-of-carrageenans-a-prediction-model-for-hybrid-carrageenans
#17
María D Torres, Francisco Chenlo, Ramón Moreira
water adsorption and desorption isotherms of kappa/iota-hybrid carrageenan (KIC) extracted from Mastocarpus stellatus red seaweed as well as commercial kappa-carrageenan (KC) and iota-carrageenan (IC) were obtained at several temperatures (5, 25, 45, 65°C). Spectroscopic and X-ray diffraction techniques allowed identifying the fundamental composition of above biopolymers. Crystallinity values (%) followed the order IC (25.4±0.6)> KIC (9.3±0.4)> KC (4.8±0.2), which nicely matched with the hygroscopic properties of the tested biopolymers (KC > KIC > IC) at each temperature...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29100513/ghrelin-therapy-improves-lung-and-cardiovascular-function-in-experimental-emphysema
#18
Nazareth de Novaes Rocha, Milena Vasconcellos de Oliveira, Cássia Lisboa Braga, Gabriela Guimarães, Lígia de Albuquerque Maia, Gisele de Araújo Padilha, Johnatas Dutra Silva, Christina Maeda Takiya, Vera Luiza Capelozzi, Pedro Leme Silva, Patricia Rieken Macedo Rocco
BACKGROUND: Emphysema is a progressive disease characterized by irreversible airspace enlargement followed by a decline in lung function. It also causes extrapulmonary effects, such as loss of body mass and cor pulmonale, which are associated with shorter survival and worse clinical outcomes. Ghrelin, a growth-hormone secretagogue, stimulates muscle anabolism, has anti-inflammatory effects, promotes vasodilation, and improves cardiac performance. Therefore, we hypothesized that ghrelin might reduce lung inflammation and remodelling as well as improve lung mechanics and cardiac function in experimental emphysema...
November 3, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29099689/identification-of-novel-small-rnas-in-burkholderia-cenocepacia-kc-01-expressed-under-iron-limitation-and-oxidative-stress-conditions
#19
Suparna Ghosh, Chetna Dureja, Indu Khatri, Srikrishna Subramanian, Saumya Raychaudhuri, Sagarmoy Ghosh
Small RNA (sRNA)-mediated regulation of gene expression is a major tool to understand bacterial responses to environmental changes. In particular, pathogenic bacteria employ sRNAs to adapt to the host environment and establish infection. Members of the Burkholderia cepacia complex, normally present in soil microbiota, cause nosocomial lung infection especially in hospitalized cystic fibrosis patients. We sequenced the draft genome of Burkholderia cenocepacia KC-01, isolated from the coastal saline soil, and identified several potential sRNAs in silico...
November 3, 2017: Microbiology
https://www.readbyqxmd.com/read/29097675/in-vivo-measurement-of-regional-corneal-tangent-modulus
#20
Ying Hon, Guo-Zhen Chen, Shu-Hao Lu, David Cc Lam, Andrew Kc Lam
Currently available clinical devices are unable to measure corneal biomechanics other than at the central region. Corneal stiffness (S), thickness, and radius of curvature was measured at the central cornea (primary fixation) and 3 mm from the temporal limbus (primary and nasal fixations). The corneal tangent modulus (E) of 25 healthy subjects was calculated from these data. After confirming normality, repeated measures analysis of variance (RMANOVA) revealed significant difference in S (F(2, 48) = 21.36, p < 0...
November 2, 2017: Scientific Reports
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