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https://www.readbyqxmd.com/read/27919628/trivalent-pneumococcal-protein-vaccine-protects-against-experimental-acute-otitis-media-caused-by-streptococcus-pneumoniae-in-an-infant-murine-model
#1
Qingfu Xu, Karin Pryharski, Michael E Pichichero
BACKGROUND: Currently licensed serotype-based pneumococcal vaccines are effective in preventing invasive pneumococcal diseases, but less effective in preventing non-bacteremic pneumonia and acute otitis media (AOM). We previously reported that a trivalent pneumococcal protein recombinant vaccine (PPrV) protected against pneumonia in a murine model. Here we evaluated PPrV protection against AOM in an infant murine model. METHODS: C57BL/6J mice were intramuscularly vaccinated at 1-3weeks of age with monovalent pneumococcal histidine triad protein D (PhtD), or pneumococcal choline binding protein A (PcpA), or detoxified pneumolysin (PlyD1), or trivalent vaccine, and transtympanically challenged at 7-8weeks of age with 1×10(2)CFU of pneumococcal strain BG7322 (6A) or 1×10(4)CFU of pneumococcal nontypeable strain 0702064MEF...
December 2, 2016: Vaccine
https://www.readbyqxmd.com/read/27915031/acid-ceramidase-deficiency-is-characterized-by-a-unique-plasma-cytokine-and-ceramide-profile-that-is-altered-by-therapy
#2
Shaalee Dworski, Ping Lu, Aneal Khan, Bruno Maranda, John J Mitchell, Rossella Parini, Maja Di Rocco, Boris Hugle, Makoto Yoshimitsu, Bo Magnusson, Balahan Makay, Nur Arslan, Norberto Guelbert, Karoline Ehlert, Andrea Jarisch, Janet Gardner-Medwin, Rawane Dagher, Maria Teresa Terreri, Charles Marques Lorenco, Lilianna Barillas-Arias, Pranoot Tanpaiboon, Alexander Solyom, James S Norris, Xingxuan He, Edward H Schuchman, Thierry Levade, Jeffrey A Medin
Acid Ceramidase Deficiency (Farber disease, FD) is an ultra-rare Lysosomal Storage Disorder that is poorly understood and often misdiagnosed as Juvenile Idiopathic Arthritis (JIA). Hallmarks of FD are accumulation of ceramides, widespread macrophage infiltration, splenomegaly, and lymphocytosis. The cytokines involved in this abnormal hematopoietic state are unknown. There are dozens of ceramide species and derivatives, but the specific ones that accumulate in FD have not been investigated. We used a multiplex assay to analyze cytokines and mass spectrometry to analyze ceramides in plasma from patients and mice with FD, controls, Farber patients treated by hematopoietic stem cell transplantation (HSCT), JIA patients, and patients with Gaucher disease...
December 1, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27914092/synthesis-characterization-and-study-of-in-vitro-cytotoxicity-of-zno-fe3o4-magnetic-composite-nanoparticles-in-human-breast-cancer-cell-line-mda-mb-231-and-mouse-fibroblast-nih-3t3
#3
Gunjan Bisht, Sagar Rayamajhi, Biplab Kc, Siddhi Nath Paudel, Deepak Karna, Bhupal G Shrestha
Novel magnetic composite nanoparticles (MCPs) were successfully synthesized by ex situ conjugation of synthesized ZnO nanoparticles (ZnO NPs) and Fe3O4 NPs using trisodium citrate as linker with an aim to retain key properties of both NPs viz. inherent selectivity towards cancerous cell and superparamagnetic nature, respectively, on a single system. Successful characterization of synthesized nanoparticles was done by XRD, TEM, FTIR, and VSM analyses. VSM analysis showed similar magnetic profile of thus obtained MCPs as that of naked Fe3O4 NPs with reduction in saturation magnetization to 16...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27911797/meeting-the-sustainable-development-goals-leads-to-lower-world-population-growth
#4
Guy J Abel, Bilal Barakat, Samir Kc, Wolfgang Lutz
Here we show the extent to which the expected world population growth could be lowered by successfully implementing the recently agreed-upon Sustainable Development Goals (SDGs). The SDGs include specific quantitative targets on mortality, reproductive health, and education for all girls by 2030, measures that will directly and indirectly affect future demographic trends. Based on a multidimensional model of population dynamics that stratifies national populations by age, sex, and level of education with educational fertility and mortality differentials, we translate these goals into SDG population scenarios, resulting in population sizes between 8...
November 29, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27909226/unique-cytokine-and-chemokine-responses-to-exertional-heat-stroke-in-mice
#5
Michelle A King, Lisa R Leon, Deborah A Morse, Thomas L Clanton
In heat stroke, cytokines are believed to play important roles in multi-organ dysfunction and recovery of damaged tissue. The time course of the cytokine response is well defined in passive heat stroke (PHS), but little is known about exertional heat stroke (EHS). In this study we used a recently developed mouse EHS model to measure the responses of circulating cytokines/chemokines and cytokine gene expression in muscle. A very rapid increase in circulating IL-6 was observed at max core temperature (Tc,max) that peaked at 0...
December 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27907090/forkhead-box-c1-regulates-human-primary-keratinocyte-terminal-differentiation
#6
Lianghua Bin, Liehua Deng, Hengwen Yang, Leqing Zhu, Xiao Wang, Michael G Edwards, Brittany Richers, Donald Y M Leung
The epidermis serves as a critical protective barrier between the internal and external environment of the human body. Its remarkable barrier function is established through the keratinocyte (KC) terminal differentiation program. The transcription factors specifically regulating terminal differentiation remain largely unknown. Using a RNA-sequencing (RNA-seq) profiling approach, we found that forkhead box c 1 (FOXC1) was significantly up-regulated in human normal primary KC during the course of differentiation...
2016: PloS One
https://www.readbyqxmd.com/read/27907005/intraluminal-flagellin-differentially-contributes-to-gut-dysbiosis-and-systemic-inflammation-following-burn-injury
#7
Logan Grimes, Allie Doyle, Aaron L Miller, Richard B Pyles, Gabor Olah, Csaba Szabo, Sarah Hoskins, Tonyia Eaves-Pyles
Burn injury is associated with a loss of gut barrier function, resulting in systemic dissemination of gut-derived bacteria and their products. The bacterial protein and TLR5 agonist, flagellin, induces non-specific innate immune responses. Because we detected flagellin in the serum of burn patients, we investigated whether gut-derived flagellin was a primary or secondary contributor to intestinal dysfunction and systemic inflammation following burn injury. The apical surface of polarized human intestinal epithelial cells (IECs), Caco-2BBe, were exposed to 50 or 500 ng of purified flagellin and 1 x 105 of an intestinal E...
2016: PloS One
https://www.readbyqxmd.com/read/27905489/the-mammalian-linc-complex-regulates-genome-transcriptional-responses-to-substrate-rigidity
#8
Samer G Alam, Qiao Zhang, Nripesh Prasad, Yuan Li, Srikar Chamala, Ram Kuchibhotla, Birendra Kc, Varun Aggarwal, Shristi Shrestha, Angela L Jones, Shawn E Levy, Kyle J Roux, Jeffrey A Nickerson, Tanmay P Lele
Mechanical integration of the nucleus with the extracellular matrix (ECM) is established by linkage between the cytoskeleton and the nucleus. This integration is hypothesized to mediate sensing of ECM rigidity, but parsing the function of nucleus-cytoskeleton linkage from other mechanisms has remained a central challenge. Here we took advantage of the fact that the LINC (linker of nucleoskeleton and cytoskeleton) complex is a known molecular linker of the nucleus to the cytoskeleton, and asked how it regulates the sensitivity of genome-wide transcription to substratum rigidity...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27902300/kibdelosporangium-metalli-sp-nov-isolated-from-rare-earth-mine-of-bayan-obo-in-china
#9
Yan-Ru Cao, Wen-Qing Yang, Ya Dao, Bin Hu, Zhong-Kan He, Lian-Ming Liang
A Gram-positive, sporangium-like globular bodies forming, oxidase-negative, catalase-positive isolate from the rare earth mine of Bayan Obo in China, designated strain KC 266T, was subjected to a comprehensive taxonomic study. Comparative 16S rRNA gene sequence analysis revealed that strain KC 266T represented a novel lineage within the genus Kibdelosporangium and showed highest 16S rRNA gene similarities to K. philippinense (98.5%), K. aridum subsp. largum (98.2%), K. aridum subsp. aridum (98.2%) and K. phytohabitans (98...
October 17, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902254/streptomyces-krungchingensis-sp-nov-isolated-from-soil-in-thailand
#10
Paranee Sripreechasak, Wongsakorn Phongsopitanun, Tomohiko Tamura, Somboon Tanasupawat
A novel actinomycete, designated KC-035T, was isolated from soil collected from Krung Ching Waterfall National Park, Nakhon Si Thammarat Province, Thailand. Its taxonomic position was determined using the polyphasic approach. The strain had morphological and chemotaxonomic properties typical of the members of the genus Streptomyces; flexuous spore chain; LL-diaminopimelic acid in cell wall peptidoglycan; MK-9(H8), MK-9(H6) and MK-9(H4) as menaquinones; diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol and phosphatidylinositol mannoside as phospholipids; anteiso-C15:0, C16:0, iso-C16:0, iso-C15:0 and iso-C14:0 as major cellular fatty acids; and 72 mol% of the DNA G+C content...
October 12, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27901481/human-pancreatic-cancer-xenografts-recapitulate-key-aspects-of-cancer-cachexia
#11
Daniel Delitto, Sarah M Judge, Andrea E Delitto, Rachel L Nosacka, Fernanda G Rocha, Bayli B DiVita, Michael H Gerber, Thomas J George, Kevin E Behrns, Steven J Hughes, Shannon M Wallet, Andrew R Judge, Jose G Trevino
Cancer cachexia represents a debilitating syndrome that diminishes quality of life and augments the toxicities of conventional treatments. Cancer cachexia is particularly debilitating in patients with pancreatic cancer (PC). Mechanisms responsible for cancer cachexia are under investigation and are largely derived from observations in syngeneic murine models of cancer which are limited in PC. We evaluate the effect of human PC cells on both muscle wasting and the systemic inflammatory milieu potentially contributing to PC-associated cachexia...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27895529/assessing-nursing-staff-s-competences-in-mobility-support-in-nursing-home-care-development-and-psychometric-testing-of-the-kinaesthetics-competence-kc-observation-instrument
#12
Heidrun Gattinger, Helena Leino-Kilpi, Virpi Hantikainen, Sascha Köpke, Stefan Ott, Beate Senn
BACKGROUND: Between 75 and 89% of residents living in long-term care facilities have limited mobility. Nurses as well as other licensed and unlicensed personnel directly involved in resident care are in a key position to promote and maintain the mobility of care-dependent persons. This requires a certain level of competence. Kinaesthetics is a training concept used to increase nursing staff's interaction and movement support skills for assisting care-dependent persons in their daily activities...
2016: BMC Nursing
https://www.readbyqxmd.com/read/27892439/lichen-planus-pigmentosus-a-study-for-association-of-thyroid-dysfunction
#13
D Karn, S Kc, M Timalsina
Background Lichen planus pigmentosus (LPP) is considered a chronic and progressive variant of lichen planus. Although pigmentation occurs in the sun exposed areas, the etiology remains unknown and there are no appropriate treatment guidelines. Association with thyroid disorder has been described in various disorders of pigmentation. Objective The objective of this study was to find the association between LPP and thyroid dysfunction. Method A total of 54 clinically diagnosed cases of LPP and 54 age and sex matched healthy control volunteers were included in this case control study...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27889721/concept-of-health-care-counseling-for-pediatricians
#14
M Kc Nair, M L Leena, K Ajithkumar
Health care counseling (HCC) is a relatively new concept that amalgamates human biology, human psychology and medical sociology principles, and applies the same in real-time clinical situations. In India, there is a real paucity of trained mental health personnel, and hence counseling services are restricted to few departments. HCC is especially important for the child population, as the pediatricians need to partner the parenting responsibilities in different illness care settings covering the period from newborn to adolescence...
November 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27888144/calcifediol-loaded-liposomes-for-local-treatment-of-pulmonary-bacterial-infections
#15
Arianna Castoldi, Christian Herr, Julia Niederstraßer, Hagar Ibrahim Labouta, Ana Melero, Sarah Gordon, Nicole Schneider-Daum, Robert Bals, Claus-Michael Lehr
The influence of vitamin D3 and its metabolites calcifediol (25(OH)D) and calcitriol on immune regulation and inflammation is well described, and raises the question of potential benefit against bacterial infections. In the current study, 25(OH)D was encapsulated in liposomes to enable aerosolisation, and tested for the ability to prevent pulmonary infection by Pseudomonas aeruginosa. Prepared 25(OH)D-loaded liposomes were nanosized and monodisperse, with a negative surface charge and a 25(OH)D entrapment efficiency of approximately 23%...
November 22, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27887936/prokineticin-2-plays-a-pivotal-role-in-psoriasis
#16
Xiaoqin He, Chuanbin Shen, Qiumin Lu, Jiong Li, Yuquan Wei, Li He, Ruizhen Bai, Jie Zheng, Ning Luan, Zhiye Zhang, Mingqiang Rong, Ren Lai
Psoriasis is histologically characterized by keratinocytes (KC) hyperproliferation, inflammation, and increased angiogenesis, but the pathological factor responsible for these symptoms is unknown. Here, a neuroendocrine peptide (prokineticin 2, PK2), is highly expressed in human and mouse psoriatic skins but no significant change in other autoimmune diseases, suggesting that PK2 is a psoriasis-specific factor. Bacterial products significantly up-regulated PK2, implying that infection induces PK2 over-expression...
October 19, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27882004/efficacy-and-safety-of-transepithelial-collagen-cross-linking-for-progressive-keratoconus
#17
Sameer Shahid Ameen, Mohammad Asim Mehboob, Kashif Ali
OBJECTIVE: To evaluate the efficacy and safety of transepithelial (TE) collagen cross-linking (CXL) in patients with progressive keratoconus (KC). METHODS: This Quasi Experimental Study was conducted at PNS Shifa Naval Hospital, Karachi from June 2015 to June 2016. Sixty eyes of 32 patients who underwent TE CXL for progressive KC from June 2015 to June 2016 were analysed to ascertain efficacy and safety of TE CXL procedure. Statistical analysis of the data was done using SPSS version 17...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27881407/prophylactic-and-therapeutic-treatment-with-flavonone-sakuranetin-ameliorates-lps-induced-acute-lung-injury
#18
Márcia Isabel Bittencourt-Mernak, Nathália Montouro Pinheiro, Fernanda P Roncon Santana, Marina P Guerreiro, Beatriz Mangueira Saraiva-Romanholo, Simone S Grecco, Luciana C Caperuto, Raphael J F Felizardo, Niels Olsen Saraiva Câmara, Iolanda F L Calvo Tibério, Mílton A Martins, João Henrique G Lago, Carla Máximo Prado
BACKGROUND AND PURPOSE: Sakuranetin is the main isolate flavonoid from Baccharis retusa (Asteraceae) leaves and exhibits anti-inflammatory and anti-oxidative activities. Acute respiratory distress syndrome is an acute failure of the respiratory system for which effective treatment is urgently necessary. This study investigated the preventive and therapeutic effects of sakuranetin on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. EXPERIMENTAL APPROACH: Animals were treated with intranasal sakuranetin 30 minutes before or 6 hours after instillation of LPS...
November 23, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27874084/silymarin-attenuates-cigarette-smoke-extract-induced-inflammation-via-simultaneous-inhibition-of-autophagy-and-erk-p38-mapk-pathway-in-human-bronchial-epithelial-cells
#19
Diandian Li, Jun Hu, Tao Wang, Xue Zhang, Lian Liu, Hao Wang, Yanqiu Wu, Dan Xu, Fuqiang Wen
Cigarette smoke (CS) is a major risk of chronic obstructive pulmonary disease (COPD), contributing to airway inflammation. Our previous study revealed that silymarin had an anti-inflammatory effect in CS-exposed mice. In this study, we attempt to further elucidate the molecular mechanisms of silymarin in CS extract (CSE)-induced inflammation using human bronchial epithelial cells. Silymarin significantly suppressed autophagy activation and the activity of ERK/p38 mitogen-activated protein kinase (MAPK) pathway in Beas-2B cells...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27872207/myeloid-specific-gene-deletion-of-protein-phosphatase-2a-magnifies-myd88-and-trif-dependent-inflammation-following-endotoxin-challenge
#20
Lei Sun, Tiffany T Pham, Timothy T Cornell, Kelli L McDonough, Walker M McHugh, Neal B Blatt, Mary K Dahmer, Thomas P Shanley
Protein phosphatase 2A (PP2A) is a member of the intracellular serine/threonine phosphatases. Innate immune cell activation triggered by pathogen-associated molecular patterns is mediated by various protein kinases, and PP2A plays a counter-regulatory role by deactivating these kinases. In this study, we generated a conditional knockout of the α isoform of the catalytic subunit of PP2A (PP2ACα). After crossing with myeloid-specific cre-expressing mice, effective gene knockout was achieved in various myeloid cells...
November 21, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
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